Hub : Genes

Usf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Usf2 0.24 0.13 1.1e-03 0.01 0.05 0.02 0.06 1.8e-01 2.5e-02 1.3e-01 2.0e-02
2 PL gene expression Usf2 0.07 0.04 1.3e-06 0.06 0.06 0.06 0.06 1.3e-07 2.1e-07 5.3e-07 2.6e-07
3 Brain gene expression Usf2 0.11 0.06 4.1e-08 0.08 0.09 0.06 0.09 1.5e-07 1.2e-08 1.9e-06 2.6e-08
4 BLA gene expression Usf2 0.2 0.11 1.2e-08 0.13 0.14 0.16 0.16 2.1e-07 4.3e-08 8.6e-09 1.1e-08
5 pVTA gene expression Usf2 0.06 0.04 1.7e-05 0.03 0.05 0.05 0.05 8.5e-04 3.7e-05 3.4e-05 8.4e-05
6 NAcc gene expression Usf2 0.03 0.02 6.0e-05 0.02 0.02 0.03 0.02 2.1e-04 1.2e-04 8.5e-05 2.6e-04
7 Adipose alternative TSS NM_031139.1 0.21 0.13 7.6e-14 0.1 0.09 0.09 0.09 9.7e-11 5.7e-10 5.0e-10 2.2e-10
8 Adipose isoform ratio XM_039092335.2 0.26 0.15 5.6e-17 0.12 0.11 0.11 0.11 7.5e-13 3.7e-12 5.9e-12 2.8e-12
9 IC gene expression Usf2 0.09 0.07 1.8e-03 0.07 0.04 0.07 0.06 9.4e-04 5.9e-03 6.1e-04 2.3e-03
10 Adipose mRNA stability Usf2 0.03 0.02 2.9e-04 0.03 0.02 0.03 0.02 6.8e-04 3.2e-03 8.5e-04 3.0e-03
11 Adipose alternative TSS XM_039092335.2 0.25 0.15 3.1e-15 0.1 0.1 0.1 0.1 3.7e-11 7.9e-11 4.1e-11 2.5e-11
12 Liver gene expression Usf2 0.05 0.04 8.4e-06 0.03 0.03 0.02 0.02 7.1e-04 6.2e-04 9.2e-04 1.4e-03
13 Adipose isoform ratio NM_031139.1 0.23 0.14 5.0e-16 0.1 0.11 0.1 0.11 1.3e-11 8.6e-12 1.6e-11 7.7e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.11.92.41.51.31.51.51.31.5-1.41.41.4-1.21.31.3-1.3
Area under the delay curve0.10.10.30.50.30.1-0.00.00.10.3-0.3-0.40.2-0.5-0.40.5
BMI with tail0.00.20.4-0.1-0.4-0.4-0.3-0.5-0.50.3-0.3-0.60.3-0.4-0.40.4
BMI without tail0.10.31.41.20.70.60.60.70.5-0.20.30.2-0.0-0.0-0.00.1
Body weight2.611.519.44.44.04.13.83.94.0-2.93.03.0-3.02.42.5-2.2
Weight adjusted by age0.20.20.60.80.60.40.50.60.4-0.60.60.4-0.30.4-0.0-0.3
Bone surface0.81.43.61.81.91.51.21.51.6-0.70.71.1-0.60.40.2-0.3
Bone volume1.22.14.22.12.01.81.61.71.9-1.11.11.4-0.90.70.7-0.7
Breakpoint value in progressive ratio session0.20.31.01.00.80.70.70.80.6-0.20.20.2-0.3-0.10.00.1
Number of licking bursts3.35.36.5-2.3-1.8-2.2-2.5-2.3-2.12.5-2.5-2.52.3-2.3-2.02.3
Context. condit. distance diff. score0.30.31.1-0.10.2-0.3-0.4-0.4-0.20.6-0.6-0.50.8-0.8-1.10.8
Locomotion velocity, session 10.10.10.40.0-0.5-0.10.1-0.1-0.2-0.40.40.0-0.40.60.4-0.6
Locomotion distance, session 10.40.52.21.50.90.60.30.30.60.2-0.2-0.30.6-0.5-0.80.6
Locomotion velocity, session 20.91.11.5-0.8-1.1-1.0-1.2-1.0-1.01.2-1.2-1.21.1-0.9-0.70.9
Locomotion distance, session 22.33.25.1-0.4-1.3-1.5-1.5-1.4-1.72.1-2.1-2.12.3-2.0-2.22.0
Locomotion velocity, session 30.50.51.1-0.4-0.4-0.6-0.7-0.4-0.60.8-0.8-0.81.0-0.8-1.00.7
Locomotion distance, session 31.21.33.61.91.60.90.10.70.80.9-0.9-0.71.0-1.4-1.51.4
Stereotopy head waving bouts, day 30.91.02.3-1.1-1.0-0.30.3-0.1-0.4-1.11.10.8-1.01.51.4-1.5
Stereotopy head waving duration, day 30.91.12.3-1.5-1.5-0.70.0-0.4-0.8-0.90.90.6-0.91.41.3-1.5
Locomotion velocity, session 70.20.20.50.70.70.40.20.30.40.3-0.3-0.30.5-0.6-0.60.7
Locomotion distance, session 70.20.20.70.50.80.60.40.70.60.1-0.10.20.4-0.3-0.30.3
Stereotopy head waving bouts, day 72.73.14.3-1.9-1.4-1.7-2.1-1.9-1.61.7-1.7-1.91.9-1.6-1.61.6
Stereotopy head waving duration, day 71.51.83.0-1.6-1.7-1.7-1.6-1.7-1.71.0-1.0-1.41.0-0.8-0.80.7
Locomotion velocity, session 83.84.55.4-2.0-2.0-2.3-2.2-2.2-2.32.1-2.1-2.32.1-1.9-2.21.9
Locomotion distance, session 82.63.87.4-0.7-0.6-1.4-1.7-1.3-1.32.2-2.2-2.12.6-2.4-2.72.4
Degree of sensitization distance0.50.51.2-1.0-0.30.00.30.10.1-0.70.70.9-0.80.91.1-0.9
Degree of sensitization stereotypy3.43.74.9-1.6-1.1-1.7-2.2-1.9-1.52.1-2.1-2.22.2-2.1-2.02.1
Conditioned locomotion0.60.71.2-0.6-1.0-0.9-0.9-1.1-1.00.8-0.8-0.90.7-0.7-0.40.7
Cocaine response after cond. corrected0.81.02.5-0.1-0.30.20.5-0.00.3-1.21.20.7-1.41.51.6-1.5
Cocaine response after cond. not corrected1.11.32.9-0.2-0.00.40.60.30.5-1.41.41.0-1.41.71.7-1.7
Cocaine response before conditioning0.40.52.40.21.60.90.41.01.2-0.20.20.60.3-0.1-0.20.1
Saline control response0.10.10.3-0.6-0.2-0.10.1-0.1-0.2-0.40.40.1-0.40.50.3-0.5
Bone: connectivity density0.10.20.50.70.60.50.40.40.6-0.20.20.3-0.20.20.2-0.2
Bone: cortical apparent density0.50.61.3-0.5-1.1-1.0-0.7-1.1-1.20.6-0.6-0.90.7-0.5-0.60.5
Bone: cortical area1.62.53.91.61.71.81.82.01.7-1.61.61.7-1.41.31.1-1.2
Bone: cortical porosity4.75.17.2-1.8-1.3-2.0-2.5-2.1-1.82.6-2.6-2.72.2-2.5-2.42.4
Bone: cortical porosity5.86.38.8-2.1-1.5-2.2-2.8-2.3-2.03.0-3.0-3.02.4-2.8-2.62.7
Bone: cortical thickness1.11.82.51.41.11.41.51.61.2-1.41.41.4-1.41.31.2-1.3
Bone: cortical thickness0.10.10.6-0.1-0.8-0.40.00.0-0.6-0.00.0-0.1-0.50.20.2-0.3
Bone: cortical tissue density0.70.91.6-0.6-1.2-1.2-0.8-1.2-1.30.8-0.8-1.10.8-0.7-0.70.6
Condit. Reinf. active minus inactive responses0.10.10.4-0.2-0.7-0.5-0.2-0.7-0.60.10.1-0.30.40.0-0.20.0
Condit. Reinf. active-inactive response ratio0.70.71.9-0.1-0.8-0.10.5-0.2-0.4-1.11.30.7-0.71.41.1-1.3
Condit. Reinf. active responses1.51.93.9-1.1-1.7-1.6-1.3-2.0-1.71.2-1.1-1.51.3-1.0-1.01.0
Condit. Reinf. inactive responses3.54.26.1-1.3-1.5-1.9-2.0-2.2-1.82.4-2.4-2.52.0-2.3-2.02.2
Incentive salience index mean0.30.30.8-0.3-0.7-0.7-0.4-0.9-0.70.5-0.3-0.60.7-0.4-0.50.4
Condit. Reinf. lever presses0.30.50.9-0.4-0.4-0.5-0.6-0.9-0.50.8-0.7-0.90.8-0.7-0.70.8
Condit. Reinf. active minus inactive responses0.30.41.31.20.90.80.80.70.8-0.40.40.7-0.40.30.1-0.3
Condit. Reinf. active-inactive response ratio0.00.00.10.1-0.2-0.20.0-0.3-0.2-0.10.10.0-0.10.2-0.1-0.2
Condit. Reinf. active responses0.81.13.41.71.91.41.01.31.5-0.40.40.8-0.30.10.0-0.1
Condit. Reinf. inactive responses0.71.03.81.41.91.30.21.01.40.4-0.4-0.00.4-0.8-0.60.8
Condit. Reinf. lever presses3.34.69.12.83.02.72.42.72.8-1.61.62.2-1.41.11.0-1.0
Condit. Reinf. lever reinforcers received0.81.14.11.72.01.50.91.31.6-0.20.20.7-0.1-0.2-0.30.3
Conditioned reinforcement - actives0.40.71.8-1.3-0.8-0.8-1.0-0.9-0.70.9-0.9-0.90.7-0.6-0.30.5
Conditioned reinforcement - inactives1.42.14.1-0.3-0.1-0.9-1.2-1.1-0.61.9-1.9-1.81.5-2.0-1.82.0
Conditioned locomotion1.82.34.0-2.0-1.8-1.7-1.7-1.9-1.61.4-1.4-1.61.1-1.1-0.81.0
Patch foraging indifference point 0 sec0.10.20.3-0.30.0-0.2-0.5-0.3-0.10.4-0.4-0.40.6-0.5-0.40.4
Patch foraging indifference point AUC0.30.40.9-0.7-0.9-0.8-0.7-0.8-0.90.5-0.5-0.70.3-0.3-0.10.3
Delay disc. indifference point, 0s delay0.40.41.10.80.50.10.1-0.40.20.6-0.6-0.50.5-0.9-0.81.0
Delay disc. indifference point, 16s delay0.10.10.40.40.30.1-0.1-0.20.10.4-0.4-0.50.3-0.6-0.40.6
Delay disc. indifference point, 2s delay0.40.41.71.31.10.80.60.60.90.1-0.1-0.00.0-0.4-0.20.5
Delay disc. indifference point, 24s delay0.50.52.01.41.21.00.80.70.9-0.40.40.4-0.50.10.2-0.0
Delay disc. indifference point, 4s delay0.91.01.9-0.5-0.3-0.7-1.1-0.7-0.51.2-1.2-1.41.1-1.2-1.11.2
Delay disc. indifference point, 8s delay0.00.00.10.30.30.2-0.10.20.10.1-0.1-0.10.1-0.2-0.20.2
Indifference point function ln k0.20.31.11.10.60.60.80.80.4-0.30.30.7-0.20.2-0.2-0.2
Indifference point function log k0.20.31.11.10.60.60.80.80.4-0.30.30.7-0.20.2-0.2-0.2
Patch foraging total patch changes 0 sec0.10.20.3-0.20.2-0.1-0.5-0.2-0.00.5-0.5-0.40.5-0.5-0.40.5
Patch foraging total patch changes 12 sec0.10.10.4-0.7-0.5-0.5-0.5-0.3-0.40.3-0.3-0.30.0-0.00.1-0.0
Patch foraging total patch changes 18 sec0.50.71.2-0.6-0.2-0.5-1.1-0.6-0.41.1-1.1-1.01.0-1.1-0.81.1
Patch foraging total patch changes 24 sec0.20.31.30.61.20.6-0.10.30.90.3-0.3-0.30.3-0.6-0.20.6
Patch foraging total patch changes 6 sec0.10.10.5-0.7-0.2-0.3-0.4-0.3-0.10.3-0.3-0.30.2-0.20.00.1
Patch foraging time to switch 0 sec0.20.52.0-1.4-1.1-0.7-0.8-0.8-0.7-0.00.0-0.4-0.40.30.7-0.4
Patch foraging water rate 0 sec0.50.91.4-0.7-0.9-1.1-0.6-0.9-1.01.1-1.1-0.91.2-1.0-1.11.0
Patch foraging water rate 12 sec0.40.91.90.11.20.3-0.30.30.61.2-1.2-0.41.3-1.4-1.41.4
Patch foraging water rate 18 sec0.20.30.6-0.6-0.4-0.5-0.5-0.4-0.50.7-0.7-0.50.8-0.6-0.50.6
Patch foraging water rate 24 sec2.33.37.10.00.1-0.9-1.2-0.8-0.82.3-2.3-1.62.4-2.5-2.72.6
Patch foraging water rate 6 sec0.71.02.20.81.40.5-0.00.10.81.1-1.1-0.51.1-1.4-1.31.5
Seeking ratio, delayed vs. immediate footshock0.60.71.91.01.40.70.20.40.80.6-0.7-0.40.6-1.1-0.91.2
Distance traveled before self-admin0.10.10.3-0.10.20.0-0.30.20.10.6-0.6-0.40.3-0.5-0.20.5
Distance traveled after self-admin0.70.92.61.21.61.40.61.51.4-0.40.40.6-0.50.30.4-0.2
Extensor digitorum longus weight0.93.65.91.1-0.30.82.11.30.3-2.32.31.9-2.42.42.4-2.4
Bone: elastic displacement0.10.10.4-0.10.00.30.10.40.2-0.30.30.3-0.50.40.7-0.4
Bone: elastic work1.41.92.71.61.51.71.41.61.6-1.21.21.3-1.31.01.3-1.0
Bone: endosteal estimation0.71.53.31.01.81.61.31.71.6-1.11.11.3-0.60.70.4-0.6
Bone: endosteal perimeter0.40.82.50.91.61.20.81.21.3-0.50.50.8-0.10.1-0.10.0
Epididymis fat weight0.10.40.80.80.50.60.90.80.5-0.50.60.6-0.50.50.3-0.4
Delta time in closed arm before/after self-admin1.21.11.91.41.21.11.31.01.1-1.01.01.1-0.90.80.5-0.7
Delta time in open arm before/after self-admin0.40.41.0-1.0-0.7-0.8-0.9-0.7-0.70.6-0.6-0.70.5-0.4-0.40.3
Diff in mean of infusions in LGA sessions0.60.71.3-0.8-1.1-1.1-0.7-1.0-1.20.7-0.7-0.60.7-0.7-0.60.7
Delay discount exponential model param0.10.10.3-0.6-0.4-0.3-0.1-0.2-0.2-0.20.20.3-0.10.40.3-0.4
Extinction: sum of active levers before priming5.76.37.32.42.12.72.72.72.5-2.62.62.6-2.62.32.5-2.2
Active lever presses in extinction session 64.54.56.90.91.01.92.01.91.6-2.42.42.2-2.62.52.6-2.5
Bone: final force1.62.64.82.21.81.71.91.71.7-1.51.51.5-1.51.31.0-1.2
Bone: final moment2.33.66.62.62.12.12.22.02.0-1.81.81.8-1.81.51.2-1.4
Food consumed during 24 hour testing period0.50.71.60.50.90.2-0.40.20.30.9-0.9-0.70.9-1.2-1.31.3
Glucose0.10.10.3-0.4-0.2-0.0-0.10.0-0.1-0.30.20.1-0.30.50.5-0.6
Heart weight0.30.41.1-0.10.1-0.4-0.4-0.4-0.30.7-0.7-0.81.0-0.8-1.10.9
Delay discount hyperbolic model param0.10.10.3-0.5-0.3-0.2-0.0-0.1-0.2-0.20.20.3-0.10.40.3-0.4
Intermittent access intake day 1-15 change1.53.14.32.12.02.01.91.92.0-1.61.61.8-1.71.31.4-1.2
Intermittent access intake escalation1.53.13.91.91.82.01.91.91.9-1.71.71.8-1.81.41.4-1.4
Intermittent access intake escalation 21.61.82.21.11.31.41.41.51.4-1.41.41.5-1.51.31.2-1.2
Intermitt. access day 1 inactive lever presses0.31.03.21.81.71.31.01.01.5-0.10.10.4-0.4-0.3-0.10.4
Intermitt. access day 15 inactive lever presses0.30.51.50.70.60.1-0.1-0.30.20.8-0.9-0.60.6-1.2-1.01.2
Intermitt. access escalation Index0.91.32.3-0.3-0.2-0.7-1.1-0.8-0.61.4-1.4-1.31.3-1.5-1.51.4
Intermittent access day 1 total infusions4.67.410.4-2.1-1.3-2.3-2.9-2.5-1.93.2-3.2-3.13.0-3.1-2.93.0
Intermittent access day 15 total infusions0.60.91.9-0.30.3-0.3-0.8-0.5-0.11.3-1.2-1.11.1-1.4-1.21.4
Intermittent access terminal intake (last 3 days)2.12.84.6-1.0-0.3-1.1-1.7-1.2-0.82.1-2.1-1.91.9-2.1-1.92.1
Intermittent access total infusions2.83.35.0-1.1-0.4-1.3-2.0-1.4-1.02.2-2.2-2.12.1-2.2-2.12.2
Intermittent access day 1 locomotion5.97.511.2-1.6-1.1-2.1-2.8-2.4-1.73.4-3.3-3.23.0-3.3-3.03.3
Intermittent access day 15 total locomotion1.01.83.7-0.40.1-0.6-1.2-0.9-0.31.8-1.8-1.41.5-1.9-1.51.9
Intermittent access total locomotion3.23.85.5-1.4-1.0-1.6-2.1-1.9-1.42.4-2.3-2.32.0-2.3-1.92.2
Intermittent access standard deviation0.71.44.61.92.21.61.01.41.8-0.40.40.8-0.60.00.00.1
Left kidney weight2.210.415.63.93.73.93.53.63.9-2.92.82.9-2.82.32.8-2.2
Right kidney weight3.114.119.14.24.04.44.14.34.3-3.63.53.6-3.33.13.3-2.9
Cocaine induced anxiety0.30.41.20.3-0.00.40.70.20.4-0.80.80.7-0.50.81.1-0.7
Post-drug Anxiety0.10.10.40.1-0.5-0.20.2-0.3-0.2-0.40.40.1-0.10.40.6-0.3
Baseline Anxiety0.70.81.5-0.2-0.2-0.6-1.0-0.7-0.51.2-1.2-1.10.6-1.2-1.11.1
Tail length3.313.023.84.94.64.53.94.54.4-2.92.83.4-2.72.12.2-2.0
Length with tail4.419.032.05.75.75.54.75.45.5-3.43.54.0-3.32.62.8-2.4
Length without tail2.58.213.13.63.53.53.23.33.5-2.42.42.5-2.42.02.0-1.8
Times rat made contact with spout0.20.20.60.1-0.10.20.40.30.1-0.60.60.5-0.60.70.6-0.8
Lifetime Intake2.32.84.1-1.3-0.5-1.3-1.8-1.4-1.02.0-2.0-1.81.9-2.0-2.01.9
Liver weight, left0.20.41.0-1.0-0.8-0.8-0.6-0.9-0.80.2-0.1-0.60.6-0.0-0.40.0
Liver weight, right0.10.20.7-0.6-0.8-0.50.1-0.3-0.70.10.0-0.20.10.30.3-0.3
Locomotor activity0.30.51.8-1.3-1.0-0.50.0-0.2-0.6-0.40.40.4-0.30.80.8-0.9
Locomotor testing distance0.20.42.8-1.7-1.0-0.8-0.5-0.5-0.70.0-0.0-0.10.30.30.1-0.3
Locomotor testing rearing0.71.43.4-1.8-1.4-1.4-1.3-1.1-1.31.0-1.0-0.91.3-0.7-0.90.6
Locomotion in novel chamber0.20.30.9-0.5-1.0-0.5-0.0-0.2-0.7-0.50.60.5-0.40.70.4-0.7
Locomotion in novel chamber post-restriction0.10.10.4-0.5-0.6-0.5-0.1-0.3-0.40.00.10.00.10.20.1-0.2
Fecal boli incidents, locomotor time 11.31.95.7-2.0-2.4-1.9-1.5-1.5-2.00.6-0.6-1.20.6-0.2-0.10.1
Change in fecal boli incidents, locomotor task1.51.52.80.1-0.10.61.20.80.5-1.51.41.3-1.51.61.7-1.7
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.3-0.20.0-0.2-0.3-0.20.20.2-0.20.2-0.0-0.2
Bouts of movement, locomotor time 10.80.92.30.50.70.1-0.4-0.10.41.2-1.2-0.91.2-1.5-1.21.5
Total resting periods, locomotor time 10.60.71.60.30.50.1-0.4-0.00.31.0-1.0-0.81.0-1.2-1.01.3
Rest time, locomotor task time 10.81.03.6-1.3-1.9-1.4-0.8-1.2-1.40.4-0.4-0.70.3-0.10.20.0
Distance moved, locomotor task time 10.10.20.70.30.80.30.10.50.30.2-0.30.10.3-0.5-0.60.5
Vertical activity count, locomotor time 10.30.83.41.21.81.20.51.21.30.0-0.10.40.1-0.4-0.40.4
Time >=10cm from walls, locomotor time 21.11.72.8-1.5-1.7-1.6-1.4-1.4-1.61.1-1.1-1.31.1-0.9-1.00.8
Bouts of movement, locomotor time 20.20.40.7-0.10.1-0.2-0.5-0.2-0.20.8-0.8-0.60.9-0.8-0.80.8
Total resting periods, locomotor time 20.30.50.9-0.5-0.2-0.5-0.7-0.4-0.40.9-0.9-0.70.9-0.8-0.90.8
Rest time, locomotor task time 20.30.41.2-1.0-1.1-0.9-0.8-0.7-0.80.5-0.4-0.60.4-0.20.00.1
Distance moved, locomotor task time 20.30.31.00.10.4-0.1-0.30.1-0.10.6-0.7-0.40.6-0.8-1.00.8
Vertical activity count, locomotor time 20.30.41.51.11.20.80.30.80.80.2-0.20.10.1-0.5-0.50.5
Light reinforcement 10.41.01.6-0.5-0.3-0.7-1.1-0.5-0.71.3-1.3-1.21.1-1.2-1.21.2
Light reinforcement 20.91.44.0-1.0-2.0-1.6-0.9-1.3-1.90.8-0.8-1.10.8-0.4-0.70.4
Bone: marrow area0.71.63.30.91.81.61.31.71.7-1.21.21.4-0.70.80.5-0.7
Bone: maximum diameter1.01.92.71.31.61.71.61.61.6-1.41.41.4-1.21.00.9-1.0
Bone: maximum force2.13.86.12.52.42.32.22.12.3-1.81.81.8-1.71.41.1-1.3
Bone: maximum moment2.64.67.52.72.72.52.42.42.5-2.02.02.0-1.91.61.2-1.5
Mean time between licks in bursts0.20.51.40.1-0.3-0.5-0.3-0.4-0.40.8-0.8-0.40.9-0.9-1.20.9
Mean num. licks in bursts3.35.16.42.21.52.02.52.21.8-2.52.52.5-2.32.42.1-2.4
Cd content in liver0.00.10.1-0.1-0.2-0.0-0.0-0.0-0.1-0.30.40.3-0.10.30.3-0.3
Co content in liver0.30.30.6-0.8-0.8-0.40.1-0.3-0.5-0.60.70.4-0.30.80.7-0.8
Cu content in liver1.01.22.11.41.31.31.41.31.3-0.80.91.1-0.90.70.7-0.6
Fe content in liver0.20.20.7-0.6-0.9-0.7-0.3-0.4-0.80.3-0.2-0.30.3-0.1-0.20.1
K content in liver0.00.00.2-0.4-0.2-0.2-0.1-0.1-0.10.1-0.1-0.0-0.1-0.0-0.00.0
Mg content in liver0.30.41.2-0.8-1.1-0.60.0-0.4-0.7-0.30.40.2-0.30.70.6-0.7
Mn content in liver0.50.51.6-1.2-1.1-0.6-0.3-0.4-0.7-0.50.50.2-0.60.90.8-0.9
Na content in liver0.20.20.90.20.90.6-0.00.50.70.2-0.30.0-0.2-0.3-0.10.3
Rb content in liver0.10.10.3-0.3-0.5-0.40.0-0.6-0.4-0.10.1-0.1-0.40.10.0-0.1
Se content in liver1.61.98.0-1.9-2.8-1.9-0.8-1.5-2.20.2-0.1-0.50.10.50.4-0.5
Sr content in liver0.30.21.3-1.1-0.6-0.5-0.5-0.6-0.50.0-0.0-0.10.30.10.1-0.2
Zn content in liver0.70.73.2-1.1-1.8-1.1-0.1-0.8-1.3-0.30.3-0.0-0.30.70.6-0.7
Bone: minimum diameter0.81.55.61.42.41.71.01.61.9-0.40.40.7-0.2-0.1-0.20.2
Time in familiar zone, hab. session 14.24.16.11.50.91.62.31.61.4-2.52.52.1-2.22.42.1-2.3
Time in novel zone, hab. session 15.05.06.5-2.1-1.6-2.1-2.6-1.8-2.12.3-2.3-2.42.5-2.3-2.52.3
Total zone transitions, hab. session 10.30.51.50.30.1-0.3-0.4-0.5-0.30.5-0.5-0.91.1-0.8-1.20.9
Total locomotion distance, hab. session 10.30.41.20.00.70.1-0.6-0.20.30.6-0.6-0.61.0-0.8-1.10.9
Locomotion velocity, hab. session 10.10.20.5-0.10.50.1-0.5-0.20.30.4-0.4-0.40.6-0.5-0.70.5
Time in familiar zone, hab. session 22.22.33.50.50.91.21.51.31.3-1.91.91.8-1.51.81.8-1.8
Time in novel zone, hab. session 21.01.01.6-0.3-0.8-0.9-1.1-0.8-1.01.2-1.2-1.30.9-1.1-1.11.0
Total zone transitions, hab. session 23.84.86.4-1.8-2.1-2.3-2.2-2.3-2.52.1-2.1-2.42.5-1.9-2.31.9
Total locomotion distance, hab. session 22.12.74.5-1.3-0.8-1.4-1.7-1.4-1.31.8-1.8-1.72.1-1.8-2.11.8
Locomotion velocity, hab. session 21.72.33.5-1.3-0.9-1.3-1.6-1.3-1.21.6-1.6-1.51.8-1.6-1.91.6
Novel to familiar place preference ratio0.00.00.20.00.40.10.0-0.00.20.2-0.20.00.1-0.3-0.20.3
Novelty place preference0.10.10.2-0.20.40.0-0.2-0.10.20.4-0.4-0.20.3-0.5-0.40.5
Time in novel zone, NPP test0.20.20.4-0.40.2-0.2-0.4-0.3-0.10.5-0.5-0.30.5-0.6-0.60.6
Total zone transitions, NPP test0.10.10.40.6-0.1-0.1-0.2-0.1-0.20.2-0.2-0.60.6-0.3-0.70.3
Total locomotion distance, NPP test0.71.02.91.31.71.40.81.51.5-0.50.50.9-0.20.20.0-0.2
Locomotion velocity, NPP test0.71.12.91.21.71.40.91.41.5-0.60.61.0-0.30.40.2-0.4
Intraocular pressure0.10.10.4-0.4-0.2-0.4-0.4-0.3-0.30.2-0.2-0.20.4-0.4-0.60.4
Delta distance traveled before/after self-admin1.41.43.01.61.71.51.11.41.6-1.01.01.1-0.80.80.5-0.7
Delta ambulatory time before/after self-admin0.91.23.01.51.71.51.01.21.5-0.80.80.9-0.60.50.3-0.4
Parametrial fat weight1.74.08.40.3-0.60.71.60.80.4-2.42.51.9-2.72.82.9-2.9
Pavlov. Cond. lever latency1.31.62.61.20.51.01.31.20.9-1.51.41.3-1.61.41.5-1.3
Pavlov. Cond. magazine entry latency2.53.36.3-2.1-1.1-1.7-2.0-1.2-1.52.0-2.0-1.62.5-1.7-2.11.7
Pavlov. Cond. change in total contacts4.24.57.3-1.7-0.8-1.6-2.2-1.7-1.42.5-2.4-2.22.7-2.4-2.62.4
Pavlov. Cond. index score2.53.15.6-2.0-1.0-1.6-1.9-1.4-1.42.0-2.0-1.62.4-1.8-2.01.7
Pavlov. Cond. latency score2.22.84.8-1.7-0.8-1.4-1.8-1.3-1.21.9-1.9-1.72.2-1.8-2.01.7
Pavlov. Cond. lever contacts1.11.32.5-1.1-0.2-0.8-1.2-1.0-0.61.4-1.3-1.11.6-1.3-1.41.3
Pavlov. Cond. magazine entry number2.63.36.81.90.91.61.91.21.3-2.12.11.6-2.61.92.2-1.9
Pavlov. Cond. intertrial magazine entries0.10.10.6-0.1-0.8-0.50.1-0.5-0.50.10.0-0.1-0.50.20.4-0.2
Pavlov. Cond. lever-magazine prob. diff.3.23.96.8-2.2-1.2-1.8-2.1-1.6-1.62.2-2.2-1.82.6-2.0-2.21.9
Pavlov. Cond. response bias1.31.74.0-1.7-0.8-1.2-1.4-0.9-1.01.4-1.3-0.92.0-1.1-1.41.1
Pavlov. Cond. lever latency1.82.56.3-2.4-2.5-2.1-1.7-2.0-2.20.7-0.7-1.30.8-0.3-0.40.2
Pavlov. Cond. magazine entry latency0.81.03.11.31.81.41.01.31.5-0.40.40.8-0.40.10.3-0.1
Pavlov. Cond. change in total contacts2.54.011.92.73.42.72.02.53.0-1.01.01.7-1.10.30.5-0.2
Pavlov. Cond. index score2.02.77.32.22.72.21.72.22.4-0.80.81.4-0.80.30.5-0.3
Pavlov. Cond. latency score1.52.05.91.92.41.91.41.92.1-0.50.51.1-0.60.10.3-0.1
Pavlov. Cond. lever contacts2.12.97.32.52.72.31.92.22.3-0.80.81.5-0.90.40.4-0.3
Pavlov. Cond. magazine entry number1.92.35.4-2.0-2.3-2.0-1.7-2.0-2.10.9-0.9-1.40.9-0.5-0.60.5
Pavlov. Cond. intertrial magazine entries0.20.41.0-0.8-0.9-0.8-0.7-1.0-0.80.2-0.2-0.50.2-0.10.00.1
Pavlov. Cond. lever-magazine prob. diff.2.02.67.02.12.62.21.72.12.3-0.80.81.5-0.90.40.5-0.3
Pavlov. Cond. response bias2.53.38.82.83.02.52.02.32.5-0.90.91.6-0.80.30.3-0.2
Time in closed arm before self-admin2.02.63.5-1.3-1.2-1.5-1.8-1.8-1.41.8-1.8-1.91.7-1.7-1.41.6
Time in closed arm after self-admin0.20.20.70.5-0.1-0.3-0.2-0.5-0.40.3-0.3-0.50.4-0.5-0.80.6
Time in open arm before self-admin3.63.96.31.82.12.22.02.52.2-1.91.92.1-1.81.71.7-1.6
Time in open arm after self-admin0.70.81.30.51.01.10.61.11.1-0.70.70.8-0.80.80.9-0.8
Bone: periosteal estimation1.53.25.51.72.32.22.02.32.1-1.71.71.9-1.31.31.0-1.2
Bone: periosteal perimeter0.81.32.30.81.41.41.21.51.4-1.11.11.3-0.90.90.6-0.8
Bone: post-yield work0.50.73.11.21.81.10.70.91.3-0.10.10.30.2-0.4-0.60.5
Progressive ratio test 1 active lever presses1.31.63.1-0.50.2-0.5-1.2-0.9-0.11.7-1.7-1.51.6-1.8-1.31.7
Progressive ratio test 1 breakpoint1.41.73.3-0.50.3-0.5-1.2-0.9-0.11.7-1.7-1.51.6-1.8-1.41.8
Progressive ratio test 1 inactive lever presses2.63.87.8-0.20.2-1.0-1.5-1.6-0.72.4-2.4-2.22.3-2.7-2.82.7
Progressive ratio test 2 active lever presses0.40.40.9-0.5-0.1-0.4-0.7-0.4-0.21.0-1.0-0.80.6-0.9-0.60.8
Progressive ratio test 2 breakpoint0.50.61.2-0.7-0.2-0.5-0.8-0.5-0.31.1-1.1-0.90.7-1.0-0.70.9
Progressive ratio test 2 inactive lever presses0.71.12.60.60.3-0.3-0.5-0.6-0.21.2-1.2-1.21.1-1.6-1.51.6
Incentive Sensitization - Responses0.10.20.3-0.4-0.4-0.5-0.3-0.2-0.40.6-0.5-0.40.2-0.5-0.40.4
Incentive Sensitization - Breakpoint0.10.10.3-0.3-0.4-0.4-0.3-0.2-0.40.5-0.5-0.30.2-0.4-0.40.4
Sum of active levers in priming session hrs 5-60.10.10.1-0.1-0.20.10.20.2-0.1-0.40.40.3-0.40.40.4-0.3
Progressive ratio0.61.01.4-1.1-0.5-0.8-1.1-0.8-0.61.1-1.2-1.11.2-1.0-0.91.0
Food seeking constrained by brief footshock0.40.51.90.71.41.00.60.81.2-0.10.10.4-0.10.00.1-0.0
Seeking ratio, punishment vs. effort0.20.20.80.90.80.60.60.50.7-0.20.20.4-0.20.10.0-0.0
Retroperitoneal fat weight0.83.58.7-0.9-1.30.11.00.4-0.3-2.22.11.6-2.22.82.8-2.9
Reaction time number correct0.10.10.40.20.10.20.60.20.2-0.20.20.6-0.10.20.3-0.2
Reaction time mean minus median0.20.61.01.00.70.90.70.80.8-0.80.80.8-0.70.70.8-0.6
Reaction time mean minus median AUC0.61.62.11.41.21.41.31.21.4-1.31.31.3-1.21.11.3-1.0
Reaction time num false alarms0.50.71.9-1.4-0.9-1.0-0.9-1.1-0.90.7-0.7-0.80.4-0.6-0.40.5
Reaction time num false alarms AUC0.71.13.5-1.9-1.2-1.3-1.2-1.4-1.20.8-0.8-0.90.6-0.6-0.50.6
Reaction time trials correct on left0.10.10.40.20.10.20.60.20.2-0.20.20.6-0.10.20.3-0.2
Reaction time trials on left0.10.10.50.20.10.20.70.30.3-0.30.30.6-0.20.30.3-0.3
Reaction time mean0.10.20.60.70.60.60.20.50.5-0.20.20.2-0.00.0-0.2-0.0
Reaction time mean AUC0.00.10.20.50.40.40.10.40.3-0.20.20.2-0.10.1-0.1-0.1
Median of all reaction times0.10.10.40.20.20.1-0.30.0-0.00.2-0.2-0.20.4-0.4-0.60.4
Reaction time omissions0.20.30.60.0-0.00.20.40.30.1-0.80.80.6-0.30.80.4-0.8
Reaction time false alarm rate0.71.02.6-1.6-0.9-1.1-1.3-1.2-1.00.8-0.8-1.00.6-0.7-0.70.6
Reaction time premature initiation rate1.21.62.7-0.9-0.2-0.8-1.4-1.0-0.61.5-1.5-1.71.4-1.6-1.31.5
Reaction time premature initiations0.61.11.8-0.7-0.2-0.6-1.0-0.8-0.41.4-1.4-1.31.2-1.3-1.01.3
Std. dev. reaction times0.30.61.41.11.21.10.60.91.0-0.50.50.6-0.30.20.2-0.2
Reaction time trials completed0.10.10.50.20.10.20.70.30.3-0.30.30.6-0.20.30.3-0.3
Reaction time trials AUC0.10.30.70.20.00.30.80.40.3-0.50.50.8-0.40.60.6-0.6
Run reversals in cocaine runway, females0.50.51.41.21.20.90.70.81.0-0.30.30.4-0.5-0.00.10.1
Run reversals in cocaine runway, males2.12.14.9-0.2-0.50.41.10.60.3-1.91.91.7-1.52.21.9-2.2
Latency to leave start box in cocaine runway0.20.21.01.00.70.60.20.10.70.2-0.2-0.1-0.3-0.3-0.00.3
Latency to leave start box in cocaine runway, F0.20.20.40.60.30.00.0-0.30.00.5-0.5-0.50.2-0.6-0.60.6
Latency to leave start box in cocaine runway, M0.10.10.20.20.40.3-0.3-0.00.40.3-0.3-0.1-0.2-0.30.00.3
Std. dev. time between licks in bursts2.23.05.1-1.2-0.5-1.3-1.7-1.3-1.02.1-2.1-1.62.1-2.2-2.32.2
Total sessions with >9 infusions0.91.02.1-1.5-0.8-1.1-1.2-1.0-0.91.0-1.0-1.01.0-0.8-0.90.7
Short access day 1 total inactive lever presses1.72.25.40.70.7-0.3-0.7-0.7-0.01.9-1.9-1.61.6-2.3-2.02.3
Short access day 10 total inactive lever presses0.40.94.12.01.40.90.90.61.00.2-0.30.00.2-0.8-0.70.9
Short access day 1 total infusions0.40.61.5-0.4-0.0-0.5-0.6-0.5-0.41.0-0.9-0.80.7-0.9-1.20.9
Short access day 10 total infusions0.81.01.6-1.1-0.4-0.8-1.3-0.9-0.61.2-1.2-1.00.9-1.1-1.11.0
Short access total infusions1.01.31.9-1.4-0.7-1.1-1.3-1.2-0.91.3-1.3-1.11.1-1.1-1.21.0
Short access day 1 locomotion0.70.81.1-1.1-0.8-1.0-1.0-1.0-1.01.0-1.0-1.00.4-0.8-0.80.7
Short access day 10 total locomotion1.22.34.3-0.60.2-0.7-1.5-0.9-0.42.0-2.0-1.61.7-2.1-1.92.0
Short access total locomotion2.83.44.5-1.8-1.2-1.7-2.1-1.9-1.62.1-2.1-2.11.7-1.8-1.81.8
One hour access (0.3 mA shock)1.92.14.7-0.00.9-0.2-1.1-0.50.21.9-1.9-1.41.8-2.1-1.92.2
Compulsive drug intake1.11.32.8-0.4-0.1-0.7-0.8-1.0-0.61.4-1.4-1.11.7-1.5-1.51.5
One hour access (shock baseline)0.50.71.5-0.20.3-0.3-0.9-0.3-0.11.1-1.1-1.00.9-1.2-1.11.2
Social response proportion1.21.42.21.41.01.21.51.31.0-1.21.21.4-1.30.90.8-0.8
Social responses0.20.20.50.30.00.30.70.40.2-0.60.60.6-0.70.50.5-0.5
Social time0.91.23.01.71.71.41.31.51.4-0.40.41.0-0.4-0.0-0.20.1
Soleus weight0.10.30.70.3-0.30.10.50.2-0.0-0.60.60.4-0.80.70.7-0.8
Bone: stiffness1.32.13.92.01.61.51.81.41.5-1.41.41.4-1.31.10.7-1.0
Tibialis anterior weight1.13.86.41.40.21.22.01.50.7-2.32.32.0-2.52.42.4-2.4
Time to tail flick, vehicle, before self-admin0.60.61.1-0.6-0.5-0.7-0.8-0.7-0.61.0-1.0-0.81.0-0.9-0.80.9
Time to tail flick, vehicle, after self-admin0.00.00.2-0.2-0.0-0.1-0.4-0.2-0.10.2-0.2-0.30.1-0.1-0.30.1
Time to tail flick, test, before self-admin0.90.92.10.60.4-0.1-0.4-0.4-0.01.1-1.1-0.91.2-1.4-1.31.5
Time to tail flick, test, after self-admin0.10.10.2-0.3-0.5-0.4-0.3-0.3-0.40.2-0.2-0.30.3-0.2-0.20.2
Delta time to tail flick, vehicle, before/after SA0.10.10.30.30.60.4-0.00.20.4-0.10.10.1-0.20.1-0.0-0.1
Delta time to tail flick, test, before/after SA0.60.61.4-1.2-1.1-0.5-0.1-0.2-0.6-0.70.70.3-0.71.11.0-1.2
Tibia length2.05.511.63.43.02.92.72.82.7-2.02.12.1-1.41.41.1-1.3
Ambulatory time before self-admin0.10.10.3-0.00.1-0.0-0.40.30.10.6-0.6-0.40.3-0.6-0.10.5
Ambulatory time after self-admin1.41.74.41.92.11.81.11.91.9-0.60.60.8-0.70.30.4-0.2
Bone: tissue strength0.90.93.11.71.81.30.90.91.4-0.40.40.4-0.4-0.0-0.20.1
Total heroin consumption0.20.20.60.50.50.2-0.00.20.20.5-0.5-0.50.4-0.7-0.60.8
Bone: trabecular number0.91.63.51.91.61.51.41.41.6-0.90.91.2-0.90.70.7-0.7
Bone: trabecular spacing0.10.10.4-0.60.30.2-0.10.30.3-0.30.30.3-0.30.40.5-0.4
Bone: trabecular thickness0.20.20.70.80.30.50.60.20.4-0.40.40.2-0.50.30.3-0.3
Bone: trabecular tissue density0.71.12.5-1.1-1.2-0.40.2-0.3-0.6-1.11.10.6-1.11.51.4-1.6
Water consumed over 24 hours0.60.81.61.31.01.01.01.10.9-0.70.70.8-0.70.60.6-0.6
Number of responses in last shaping day0.50.61.2-0.20.5-0.1-0.5-0.10.11.0-1.0-0.71.0-1.1-1.11.0