Hub : Genes

Urgcp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr14_84819217_84852612	0.03	0.02	3.1e-03	0.03	0.04	0.02	0.04	8.7e-04	8.0e-04	1.4e-02	7.9e-04
2	LHb	alternative TSS	XM_006251315.5	0.18	0.13	4.5e-03	0.08	0.08	0.05	0.03	5.5e-03	5.6e-03	2.7e-02	6.7e-02
3	NAcc	mRNA stability	Urgcp	0.04	0.03	1.4e-04	0.03	0.01	0.02	0.02	9.5e-06	9.9e-03	3.8e-04	1.5e-04
4	RMTg	isoform ratio	NM_001077660.2	0.56	0.19	1.8e-03	0.11	0.05	0.1	0.1	8.4e-04	1.6e-02	1.4e-03	1.3e-03
5	Brain	mRNA stability	Urgcp	0.16	0.08	1.6e-06	0.06	0.07	0.06	0.07	1.8e-06	3.5e-07	2.4e-06	2.9e-07
6	BLA	mRNA stability	Urgcp	0.25	0.15	4.3e-04	0.04	0.06	0.05	0.06	2.4e-03	6.6e-04	1.6e-03	6.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	0.2	0.1	0.1	0.0	-0.0	-0.2
Area under the delay curve	2.2	2.6	4.8	-2.2	1.9	-1.9	1.3	-1.3	-0.2
BMI with tail	0.1	0.4	1.1	-0.7	1.1	-0.7	0.2	-0.2	0.1
BMI without tail	0.3	0.9	2.8	-1.3	1.7	-0.8	0.5	-0.5	-0.1
Body weight	0.9	3.7	8.2	-2.9	2.8	-2.3	0.7	-0.7	0.4
Weight adjusted by age	0.2	0.4	0.9	-0.9	0.9	-0.5	0.3	-0.3	-0.1
Bone surface	0.1	0.2	0.6	-0.2	0.0	-0.3	-0.5	0.5	0.8
Bone volume	0.1	0.2	0.4	-0.2	0.2	-0.3	-0.4	0.4	0.6
Breakpoint value in progressive ratio session	0.5	0.6	1.5	-1.1	1.2	-1.0	0.1	-0.1	0.3
Number of licking bursts	1.1	1.8	3.9	-2.0	1.6	-1.9	-0.3	0.3	0.9
Context. condit. distance diff. score	2.1	2.5	5.6	2.4	-2.1	2.2	-0.6	0.6	-0.2
Locomotion velocity, session 1	0.3	0.3	0.4	0.2	-0.6	0.5	-0.6	0.6	0.5
Locomotion distance, session 1	1.5	1.8	3.6	0.2	0.6	-0.4	1.8	-1.8	-1.9
Locomotion velocity, session 2	1.5	1.8	2.8	0.6	-1.1	1.0	-1.7	1.7	1.6
Locomotion distance, session 2	0.5	0.7	1.4	1.2	-0.6	0.7	0.7	-0.7	-0.9
Locomotion velocity, session 3	0.7	0.8	2.6	1.6	-1.0	0.8	0.3	-0.3	-0.8
Locomotion distance, session 3	0.3	0.4	1.2	-0.2	0.6	-1.1	-0.2	0.2	0.7
Stereotopy head waving bouts, day 3	0.2	0.3	0.6	0.8	-0.3	0.6	0.3	-0.3	-0.7
Stereotopy head waving duration, day 3	1.0	1.2	2.5	1.5	-1.3	1.6	0.0	-0.0	-0.9
Locomotion velocity, session 7	0.1	0.1	0.4	-0.2	0.2	-0.1	-0.3	0.3	0.6
Locomotion distance, session 7	0.2	0.2	0.4	0.6	-0.4	0.6	-0.3	0.3	0.4
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	0.5	-0.7	0.8	-0.5	0.5	0.2
Stereotopy head waving duration, day 7	0.0	0.1	0.1	0.2	-0.4	0.3	0.1	-0.1	-0.3
Locomotion velocity, session 8	2.1	2.5	4.4	1.9	-2.1	2.1	-1.1	1.1	0.8
Locomotion distance, session 8	3.5	5.1	12.0	3.5	-2.8	3.1	-0.1	0.1	-1.0
Degree of sensitization distance	2.0	2.1	5.8	1.6	-1.9	2.4	-0.6	0.6	-0.2
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.0	-0.3	0.3	-0.3	0.3	0.2
Conditioned locomotion	1.6	1.8	3.6	0.4	0.4	-0.5	1.8	-1.8	-1.9
Cocaine response after cond. corrected	0.8	1.0	2.4	-1.6	1.1	-1.4	-0.2	0.2	0.5
Cocaine response after cond. not corrected	1.2	1.4	3.2	-1.8	1.5	-1.7	0.0	-0.0	0.2
Cocaine response before conditioning	0.2	0.2	0.7	0.3	0.1	-0.0	0.5	-0.5	-0.8
Saline control response	0.3	0.4	0.8	0.9	-0.8	0.8	-0.6	0.6	0.3
Bone: connectivity density	0.1	0.1	0.3	0.6	-0.3	0.5	-0.1	0.1	-0.1
Bone: cortical apparent density	0.1	0.2	0.5	-0.7	0.3	-0.2	-0.3	0.3	0.6
Bone: cortical area	1.3	2.0	4.1	-2.0	1.8	-2.0	0.6	-0.6	0.3
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.5	-0.4	0.2	-0.2	0.1
Bone: cortical porosity	0.2	0.2	0.3	0.1	0.2	-0.1	0.6	-0.6	-0.5
Bone: cortical thickness	1.3	2.2	4.8	-1.9	1.9	-2.2	0.8	-0.8	-0.0
Bone: cortical thickness	0.7	0.9	1.8	0.3	0.4	-0.3	1.2	-1.2	-1.3
Bone: cortical tissue density	0.2	0.2	0.5	-0.7	0.3	-0.2	-0.4	0.4	0.7
Condit. Reinf. active minus inactive responses	0.7	0.8	2.1	-0.6	0.3	-0.2	-1.0	1.0	1.4
Condit. Reinf. active-inactive response ratio	2.3	2.5	3.9	0.5	-1.1	1.5	-2.0	2.0	1.8
Condit. Reinf. active responses	0.2	0.3	0.9	-0.4	0.3	-0.6	-0.4	0.4	0.9
Condit. Reinf. inactive responses	0.8	1.0	3.0	-0.5	0.9	-1.7	0.9	-0.9	-0.4
Incentive salience index mean	0.6	0.7	1.2	-1.1	1.0	-1.0	-0.3	0.3	1.0
Condit. Reinf. lever presses	1.1	1.5	2.1	-0.9	1.4	-1.5	1.3	-1.3	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	1.1	-0.8	0.7	0.2	-0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.2	0.0	0.1	0.3	-0.3	-0.3
Condit. Reinf. active responses	0.4	0.5	1.3	1.1	-0.8	0.9	0.2	-0.2	-0.6
Condit. Reinf. inactive responses	0.5	0.7	1.5	1.1	-1.1	1.2	-0.3	0.3	-0.1
Condit. Reinf. lever presses	0.3	0.4	1.0	1.0	-0.9	0.6	-0.0	0.0	-0.4
Condit. Reinf. lever reinforcers received	0.3	0.4	1.0	1.0	-0.6	0.8	0.2	-0.2	-0.5
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.4	0.2	0.1	0.2	-0.2	0.1
Conditioned reinforcement - inactives	0.3	0.4	0.8	-0.9	0.8	-0.8	-0.0	-0.0	0.5
Conditioned locomotion	0.2	0.3	0.9	-0.7	0.9	-0.1	0.4	-0.4	0.1
Patch foraging indifference point 0 sec	1.5	2.8	5.5	-1.2	0.7	-0.6	-2.1	2.1	2.3
Patch foraging indifference point AUC	0.2	0.3	0.6	-0.0	-0.1	0.5	-0.8	0.8	0.6
Delay disc. indifference point, 0s delay	0.8	0.9	2.0	-1.4	1.0	-1.3	0.4	-0.4	-0.0
Delay disc. indifference point, 16s delay	0.9	1.0	2.5	-1.6	1.5	-1.0	0.4	-0.4	0.3
Delay disc. indifference point, 2s delay	2.7	3.0	5.3	-1.9	1.8	-2.3	1.6	-1.6	-0.8
Delay disc. indifference point, 24s delay	0.8	0.9	2.0	-1.4	1.2	-1.1	0.5	-0.6	0.2
Delay disc. indifference point, 4s delay	2.8	3.0	4.8	-2.2	2.0	-2.0	1.5	-1.5	-0.5
Delay disc. indifference point, 8s delay	1.1	1.3	1.8	-1.2	1.1	-1.1	1.4	-1.4	-0.6
Indifference point function ln k	0.4	0.8	1.3	-0.2	0.6	-1.2	1.0	-1.1	-0.8
Indifference point function log k	0.4	0.8	1.3	-0.2	0.6	-1.2	1.0	-1.1	-0.8
Patch foraging total patch changes 0 sec	1.7	3.3	6.5	-1.2	0.6	-0.5	-2.4	2.4	2.5
Patch foraging total patch changes 12 sec	1.5	1.9	3.7	-0.7	0.2	0.2	-1.9	1.9	1.9
Patch foraging total patch changes 18 sec	2.3	3.5	6.7	-0.6	-0.1	0.5	-2.6	2.6	2.6
Patch foraging total patch changes 24 sec	2.4	4.1	6.1	1.8	-1.8	2.5	-2.3	2.3	1.4
Patch foraging total patch changes 6 sec	1.9	3.0	5.8	-1.3	1.0	-0.7	-2.1	2.1	2.4
Patch foraging time to switch 0 sec	0.3	0.6	1.2	0.6	-0.5	0.6	0.9	-0.9	-1.1
Patch foraging water rate 0 sec	1.1	2.3	4.2	-1.3	0.9	-1.1	-1.7	1.7	2.1
Patch foraging water rate 12 sec	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.4	0.4	0.6
Patch foraging water rate 18 sec	1.9	2.9	5.4	-0.4	1.3	-1.1	2.3	-2.3	-1.9
Patch foraging water rate 24 sec	0.0	0.1	0.2	0.1	0.5	0.3	0.2	-0.2	0.1
Patch foraging water rate 6 sec	0.5	0.8	1.5	-0.7	1.0	-1.2	0.8	-0.8	-0.4
Seeking ratio, delayed vs. immediate footshock	1.5	1.9	4.0	0.0	0.6	0.3	2.0	-2.0	-1.7
Distance traveled before self-admin	0.2	0.2	0.5	0.1	-0.3	-0.0	-0.7	0.7	0.5
Distance traveled after self-admin	0.1	0.2	0.3	-0.2	0.4	-0.1	0.6	-0.6	-0.4
Extensor digitorum longus weight	1.4	5.6	13.0	-3.6	3.0	-3.0	-0.2	0.2	1.7
Bone: elastic displacement	0.2	0.2	0.6	0.5	-0.5	0.8	-0.1	0.1	-0.4
Bone: elastic work	0.4	0.5	0.9	-0.8	1.0	-0.5	0.7	-0.7	-0.6
Bone: endosteal estimation	0.0	0.0	0.1	-0.0	-0.2	0.3	-0.2	0.2	0.1
Bone: endosteal perimeter	0.3	0.7	1.2	-1.1	0.9	-0.8	0.8	-0.8	-0.4
Epididymis fat weight	0.2	0.8	1.7	-1.2	1.2	-1.3	0.1	-0.1	0.3
Delta time in closed arm before/after self-admin	5.5	5.1	7.5	2.6	-2.1	2.0	2.0	-2.0	-2.7
Delta time in open arm before/after self-admin	3.8	3.8	5.8	-2.4	1.6	-1.6	-1.9	1.9	2.2
Diff in mean of infusions in LGA sessions	0.4	0.5	1.1	-0.0	0.3	-0.1	1.1	-1.1	-0.8
Delay discount exponential model param	2.2	2.4	4.5	2.1	-1.9	1.8	-1.2	1.2	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.2	0.2	0.5	-0.2	0.2	0.3
Active lever presses in extinction session 6	1.2	1.1	2.4	-0.3	0.4	-0.6	1.6	-1.5	-1.2
Bone: final force	0.1	0.2	0.6	-0.3	0.2	-0.1	-0.5	0.5	0.8
Bone: final moment	0.2	0.3	0.6	-0.5	0.4	-0.3	-0.5	0.5	0.8
Food consumed during 24 hour testing period	1.0	1.3	3.3	-1.1	0.3	-0.7	-1.2	1.2	1.8
Glucose	11.1	17.4	42.4	-3.1	0.4	-0.5	-5.1	5.1	6.5
Heart weight	1.3	1.9	3.7	0.3	-0.7	0.5	-1.9	1.9	1.9
Delay discount hyperbolic model param	2.5	2.8	4.8	2.2	-2.0	2.0	-1.4	1.4	0.3
Intermittent access intake day 1-15 change	0.7	1.5	2.9	-0.6	0.5	0.0	-1.7	1.7	1.7
Intermittent access intake escalation	0.6	1.2	2.5	-0.5	0.5	-0.1	-1.5	1.5	1.6
Intermittent access intake escalation 2	1.2	1.3	2.9	-0.1	0.1	0.0	-1.7	1.7	1.5
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.7	0.2	-0.1	0.7	0.8	-0.8	-0.7
Intermitt. access day 15 inactive lever presses	0.8	1.7	2.4	-1.5	1.2	-1.0	-1.3	1.3	1.5
Intermitt. access escalation Index	1.4	1.9	4.1	0.3	-0.1	0.8	-2.0	2.0	1.6
Intermittent access day 1 total infusions	0.6	1.0	1.8	-0.8	0.7	-0.7	1.3	-1.3	-0.8
Intermittent access day 15 total infusions	0.8	1.2	2.1	-1.4	1.3	-1.0	-0.6	0.6	1.2
Intermittent access terminal intake (last 3 days)	0.8	1.0	1.6	-0.8	0.7	-0.7	-1.2	1.2	1.3
Intermittent access total infusions	0.6	0.7	1.6	-1.3	1.1	-1.0	-0.0	0.0	0.5
Intermittent access day 1 locomotion	1.8	2.3	5.7	0.0	0.3	0.3	2.4	-2.4	-1.6
Intermittent access day 15 total locomotion	0.4	0.7	1.5	-1.0	1.2	-0.6	0.8	-0.8	-0.1
Intermittent access total locomotion	0.8	1.0	1.8	-1.2	1.3	-0.8	1.0	-1.0	-0.1
Intermittent access standard deviation	0.3	0.6	1.0	1.0	-1.0	0.9	-0.6	0.6	0.2
Left kidney weight	0.3	1.5	2.6	-1.0	1.1	-0.6	1.6	-1.6	-1.3
Right kidney weight	0.4	1.9	3.0	-0.6	1.2	-1.0	1.7	-1.7	-1.5
Cocaine induced anxiety	1.4	2.0	4.3	-2.1	1.6	-1.5	-0.7	0.7	1.4
Post-drug Anxiety	1.4	1.5	3.2	-1.8	1.7	-1.2	-0.3	0.3	1.1
Baseline Anxiety	0.6	0.7	1.4	0.5	0.1	0.5	1.2	-1.2	-0.9
Tail length	1.3	5.2	11.5	-3.4	3.3	-2.8	0.5	-0.5	0.8
Length with tail	1.1	4.8	11.0	-3.3	2.9	-2.8	0.4	-0.4	0.9
Length without tail	0.2	0.6	1.4	-1.1	0.9	-1.2	0.2	-0.2	0.2
Times rat made contact with spout	4.3	5.0	7.9	1.0	-1.9	1.5	-2.8	2.8	2.7
Lifetime Intake	0.5	0.6	1.4	-1.2	1.0	-1.0	0.2	-0.2	0.2
Liver weight, left	0.6	1.0	1.9	0.3	0.1	-0.0	1.4	-1.4	-1.4
Liver weight, right	1.1	1.9	4.2	0.8	-0.3	0.1	1.8	-1.8	-2.0
Locomotor activity	0.9	1.4	2.6	-0.8	-0.1	0.1	-1.6	1.6	1.6
Locomotor testing distance	0.2	0.3	0.7	-0.8	0.8	-0.7	0.0	-0.0	0.1
Locomotor testing rearing	0.8	1.6	2.6	-1.4	0.8	-0.9	-1.3	1.3	1.6
Locomotion in novel chamber	1.5	1.9	3.7	1.9	-1.8	1.2	0.8	-0.8	-1.3
Locomotion in novel chamber post-restriction	1.1	1.9	4.1	2.0	-1.5	1.4	0.8	-0.8	-1.3
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.1	0.2	-0.1	0.3	-0.3	-0.5
Change in fecal boli incidents, locomotor task	0.9	0.9	1.4	0.4	-0.7	0.8	-1.1	1.1	1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.3	-0.3	0.5	0.0	-0.0	-0.2
Bouts of movement, locomotor time 1	1.1	1.3	2.5	-0.0	-0.4	0.4	-1.6	1.6	1.5
Total resting periods, locomotor time 1	0.8	0.8	1.5	0.3	-0.5	0.7	-1.2	1.2	1.1
Rest time, locomotor task time 1	0.0	0.0	0.1	0.2	-0.1	0.4	-0.1	0.1	0.3
Distance moved, locomotor task time 1	0.2	0.2	0.5	-0.6	0.7	-0.3	0.5	-0.5	-0.3
Vertical activity count, locomotor time 1	0.0	0.1	0.3	-0.6	0.4	-0.3	0.0	-0.0	0.0
Time >=10cm from walls, locomotor time 2	0.7	1.0	2.3	0.1	-0.1	0.4	1.3	-1.3	-1.5
Bouts of movement, locomotor time 2	1.4	2.2	3.9	-0.6	1.5	-1.1	2.0	-2.0	-1.4
Total resting periods, locomotor time 2	0.8	1.4	2.4	-0.5	1.3	-0.9	1.6	-1.6	-1.0
Rest time, locomotor task time 2	0.4	0.5	0.9	0.5	-0.6	0.6	-0.9	0.9	0.6
Distance moved, locomotor task time 2	0.2	0.2	0.3	0.2	-0.2	0.6	0.4	-0.4	-0.6
Vertical activity count, locomotor time 2	0.2	0.2	0.5	-0.1	0.0	-0.1	0.7	-0.7	-0.7
Light reinforcement 1	0.1	0.1	0.4	-0.1	0.6	-0.1	0.5	-0.5	-0.1
Light reinforcement 2	1.9	2.9	5.7	-0.7	1.4	-0.6	2.4	-2.4	-1.7
Bone: marrow area	0.0	0.0	0.1	0.1	-0.3	0.3	-0.1	0.1	-0.0
Bone: maximum diameter	1.4	2.6	6.3	-2.5	1.7	-1.9	-0.5	0.5	1.6
Bone: maximum force	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1	0.1	0.3
Bone: maximum moment	0.1	0.2	0.4	-0.6	0.6	-0.6	0.0	-0.0	0.2
Mean time between licks in bursts	0.3	0.8	1.4	-0.8	0.1	-0.3	-1.1	1.1	1.2
Mean num. licks in bursts	2.6	4.1	6.7	2.3	-2.6	2.6	-1.5	1.5	1.0
Cd content in liver	0.5	0.6	1.1	-0.6	0.4	-0.5	-1.0	1.0	1.0
Co content in liver	0.2	0.2	0.4	-0.6	0.5	-0.2	-0.4	0.4	0.5
Cu content in liver	0.3	0.4	0.7	-0.4	-0.1	-0.1	-0.8	0.8	0.8
Fe content in liver	0.8	1.0	1.5	1.2	-0.9	1.2	0.6	-0.6	-1.1
K content in liver	3.5	3.3	5.7	-1.9	2.2	-2.4	1.6	-1.6	-0.9
Mg content in liver	0.4	0.4	1.2	-0.7	0.7	-1.1	0.3	-0.3	-0.1
Mn content in liver	0.6	0.7	1.7	-0.6	0.9	-1.3	0.8	-0.8	-0.5
Na content in liver	1.1	1.2	3.1	-1.8	1.4	-1.4	-0.1	0.1	0.7
Rb content in liver	0.7	0.8	1.8	-1.3	1.1	-1.2	-0.2	0.2	0.4
Se content in liver	1.6	1.9	4.5	-1.5	1.8	-2.1	0.8	-0.8	-0.1
Sr content in liver	2.1	1.8	4.3	-2.1	1.6	-1.8	-0.2	0.2	0.7
Zn content in liver	1.4	1.6	2.2	-1.1	1.5	-1.1	1.4	-1.4	-1.0
Bone: minimum diameter	0.1	0.2	0.5	0.0	0.1	-0.1	0.7	-0.7	-0.7
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.6	-0.3	0.4	0.1	-0.1	0.0
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	0.3	-0.4	-0.5	0.5	0.5
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	-0.2	0.1
Total locomotion distance, hab. session 1	0.5	0.7	1.3	-0.4	0.7	-0.7	1.1	-1.1	-0.7
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.2	0.4	-0.4	0.8	-0.8	-0.6
Time in familiar zone, hab. session 2	1.3	1.3	3.0	1.6	-1.3	1.7	0.1	-0.1	-0.8
Time in novel zone, hab. session 2	1.8	1.8	3.2	-1.6	1.2	-1.8	-0.8	0.8	1.5
Total zone transitions, hab. session 2	1.0	1.3	2.3	-1.2	1.3	-1.5	1.0	-1.0	-0.3
Total locomotion distance, hab. session 2	0.8	1.0	1.9	-1.0	1.2	-1.4	0.9	-0.9	-0.1
Locomotion velocity, hab. session 2	1.3	1.7	2.6	-1.3	1.5	-1.6	1.3	-1.3	-0.5
Novel to familiar place preference ratio	0.4	0.4	1.0	-0.6	-0.1	-0.1	-0.8	0.8	1.0
Novelty place preference	0.5	0.5	1.1	-0.6	-0.1	-0.1	-0.9	0.9	1.0
Time in novel zone, NPP test	0.6	0.7	1.4	-0.6	-0.1	-0.1	-1.1	1.1	1.2
Total zone transitions, NPP test	1.0	1.4	2.8	0.3	0.5	-0.5	1.7	-1.7	-1.5
Total locomotion distance, NPP test	1.4	2.0	3.5	-0.2	1.1	-1.1	1.9	-1.9	-1.5
Locomotion velocity, NPP test	1.5	2.2	3.8	-0.4	1.3	-1.1	2.0	-2.0	-1.6
Intraocular pressure	0.2	0.2	0.5	-0.7	0.4	-0.1	-0.4	0.4	0.6
Delta distance traveled before/after self-admin	0.9	0.9	1.8	0.4	0.1	0.6	1.3	-1.3	-1.2
Delta ambulatory time before/after self-admin	0.6	0.8	1.6	0.4	0.1	0.4	1.2	-1.2	-1.1
Parametrial fat weight	0.7	1.7	3.4	-1.8	1.2	-0.6	-0.9	0.9	1.8
Pavlov. Cond. lever latency	0.4	0.5	0.9	-0.3	-0.2	0.4	-1.0	1.0	0.8
Pavlov. Cond. magazine entry latency	0.7	0.9	3.0	1.7	-1.1	0.8	0.2	-0.2	-0.6
Pavlov. Cond. change in total contacts	0.7	0.7	1.7	-0.9	1.1	-1.3	-0.1	0.1	0.9
Pavlov. Cond. index score	0.6	0.8	2.1	1.5	-0.5	0.4	0.8	-0.8	-1.0
Pavlov. Cond. latency score	0.6	0.8	1.5	1.2	-0.4	0.2	0.9	-0.9	-1.1
Pavlov. Cond. lever contacts	0.5	0.6	0.9	0.8	-0.0	-0.1	1.0	-1.0	-0.9
Pavlov. Cond. magazine entry number	0.7	0.9	3.5	-1.9	1.2	-0.8	0.1	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	2.3	2.8	3.9	-1.3	1.5	-1.6	2.0	-2.0	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.6	1.6	-0.6	0.4	0.9	-0.9	-1.2
Pavlov. Cond. response bias	0.3	0.4	1.2	1.1	-0.3	-0.1	0.6	-0.6	-0.5
Pavlov. Cond. lever latency	3.2	4.4	7.9	-2.6	2.8	-2.7	1.4	-1.4	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.4	-0.7	0.4	-0.2	0.2	0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.6	-0.8	0.8	-0.3	0.3	0.0
Pavlov. Cond. index score	1.1	1.5	3.0	1.5	-1.7	1.6	-0.7	0.7	0.1
Pavlov. Cond. latency score	0.9	1.2	2.7	1.6	-1.6	1.4	-0.4	0.4	-0.1
Pavlov. Cond. lever contacts	3.3	4.5	8.5	2.7	-2.9	2.8	-1.3	1.3	0.2
Pavlov. Cond. magazine entry number	1.1	1.4	1.8	-0.8	1.3	-1.1	1.3	-1.3	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.2	0.5	-0.4	-0.0	0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	3.3	1.6	-1.8	1.6	-0.7	0.7	0.1
Pavlov. Cond. response bias	2.5	3.3	5.9	2.0	-2.4	2.4	-1.4	1.4	0.6
Time in closed arm before self-admin	0.3	0.3	1.2	-0.7	1.1	-0.6	0.2	-0.2	0.1
Time in closed arm after self-admin	1.6	1.7	2.8	1.4	-0.6	1.2	1.3	-1.3	-1.7
Time in open arm before self-admin	0.5	0.5	0.8	0.9	-0.8	0.7	0.6	-0.6	-0.7
Time in open arm after self-admin	0.4	0.5	0.9	-0.6	0.0	-0.1	-0.9	0.9	0.9
Bone: periosteal estimation	0.2	0.5	1.2	-1.1	0.8	-0.9	0.3	-0.3	0.1
Bone: periosteal perimeter	0.9	1.6	2.9	-1.7	1.6	-1.5	1.0	-1.0	-0.3
Bone: post-yield work	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.0	0.0	0.1
Progressive ratio test 1 active lever presses	0.6	0.8	1.3	-1.0	1.1	-0.6	0.9	-1.0	-0.3
Progressive ratio test 1 breakpoint	0.6	0.8	1.4	-1.0	1.2	-0.5	1.0	-1.0	-0.3
Progressive ratio test 1 inactive lever presses	3.1	4.5	9.2	-3.0	2.7	-2.3	1.6	-1.6	-0.1
Progressive ratio test 2 active lever presses	0.4	0.5	1.0	-1.0	0.9	-0.7	-0.3	0.3	0.6
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	-0.9	0.8	-0.6	-0.4	0.4	0.6
Progressive ratio test 2 inactive lever presses	0.7	1.1	2.3	-1.4	1.5	-0.8	0.8	-0.8	0.1
Incentive Sensitization - Responses	0.1	0.2	0.4	-0.4	0.2	-0.3	-0.6	0.6	0.5
Incentive Sensitization - Breakpoint	0.2	0.3	0.6	-0.2	0.1	-0.2	-0.8	0.8	0.6
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.4	-1.0	1.3	-1.6	0.7	-0.7	-0.2
Progressive ratio	0.5	0.8	1.6	0.1	0.4	0.3	1.3	-1.3	-1.1
Food seeking constrained by brief footshock	3.6	4.4	7.2	-2.1	2.3	-2.7	2.1	-2.1	-0.8
Seeking ratio, punishment vs. effort	0.8	1.1	3.6	-1.2	1.1	-1.9	0.5	-0.5	0.1
Retroperitoneal fat weight	0.2	0.7	1.6	-1.3	0.9	-0.7	-0.4	0.4	1.0
Reaction time number correct	0.3	0.6	1.2	0.4	-0.5	0.5	-1.1	1.1	0.9
Reaction time mean minus median	1.2	2.9	5.1	1.8	-2.1	2.3	-1.4	1.4	0.6
Reaction time mean minus median AUC	0.9	2.3	3.6	1.6	-1.9	1.8	-1.4	1.4	0.5
Reaction time num false alarms	0.8	1.1	3.4	-0.8	1.4	-1.8	0.6	-0.6	-0.1
Reaction time num false alarms AUC	1.0	1.6	3.8	-0.9	1.6	-1.9	1.0	-1.0	-0.5
Reaction time trials correct on left	0.3	0.6	1.2	0.4	-0.5	0.5	-1.1	1.1	0.9
Reaction time trials on left	0.4	0.7	1.2	0.4	-0.5	0.6	-1.1	1.1	0.9
Reaction time mean	0.3	0.5	1.5	0.8	-0.7	1.2	-0.0	0.0	-0.6
Reaction time mean AUC	0.4	0.7	1.7	1.0	-0.9	1.3	0.2	-0.2	-0.8
Median of all reaction times	0.2	0.3	0.8	0.4	-0.2	0.7	0.5	-0.5	-0.9
Reaction time omissions	0.6	0.9	2.3	1.2	-1.0	1.5	-0.4	0.4	-0.4
Reaction time false alarm rate	1.6	2.3	4.3	-1.0	1.7	-2.1	1.5	-1.5	-0.9
Reaction time premature initiation rate	1.2	1.7	2.5	1.6	-1.0	1.0	1.3	-1.3	-1.6
Reaction time premature initiations	0.4	0.8	1.9	1.4	-1.0	1.0	0.4	-0.4	-0.7
Std. dev. reaction times	0.9	1.6	3.5	1.4	-1.6	1.9	-0.9	0.9	0.1
Reaction time trials completed	0.4	0.7	1.2	0.4	-0.5	0.6	-1.1	1.1	0.9
Reaction time trials AUC	0.3	0.5	1.0	0.3	-0.3	0.4	-1.0	1.0	0.9
Run reversals in cocaine runway, females	0.4	0.4	0.6	0.5	-0.5	0.6	0.7	-0.7	-0.8
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.5	0.1	-0.3	-0.3	0.3	0.3
Latency to leave start box in cocaine runway	0.3	0.4	0.7	-0.8	0.7	-0.9	0.4	-0.4	-0.3
Latency to leave start box in cocaine runway, F	1.0	1.1	2.6	-1.5	1.3	-1.6	0.4	-0.4	-0.0
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	0.7	-0.5	0.6	0.3	-0.3	-0.6
Std. dev. time between licks in bursts	0.1	0.2	0.4	0.1	-0.1	0.1	-0.6	0.6	0.5
Total sessions with >9 infusions	0.5	0.6	0.8	0.7	-0.9	0.5	0.7	-0.7	-0.9
Short access day 1 total inactive lever presses	1.8	2.4	5.7	-2.4	1.9	-2.2	0.2	-0.2	0.6
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.5	0.6	-0.4	0.5	-0.5	-0.1
Short access day 1 total infusions	0.6	0.8	1.4	0.5	-0.6	0.3	1.2	-1.2	-1.1
Short access day 10 total infusions	0.3	0.4	0.7	0.3	-0.3	-0.0	0.8	-0.8	-0.8
Short access total infusions	0.1	0.2	0.3	-0.3	0.1	-0.5	0.5	-0.5	-0.4
Short access day 1 locomotion	1.8	2.2	4.7	0.7	-0.6	0.3	2.2	-2.2	-1.8
Short access day 10 total locomotion	2.0	3.7	7.5	1.2	-0.5	1.2	2.7	-2.7	-2.1
Short access total locomotion	1.4	1.6	2.4	1.1	-0.9	1.0	1.5	-1.5	-1.5
One hour access (0.3 mA shock)	0.6	0.7	1.5	-1.2	1.2	-0.9	0.6	-0.6	0.3
Compulsive drug intake	0.8	0.9	2.4	1.2	-1.6	1.1	0.1	-0.1	-0.7
One hour access (shock baseline)	0.5	0.7	1.8	-1.2	1.4	-0.7	0.3	-0.3	0.4
Social response proportion	0.9	1.0	2.4	-1.5	1.6	-1.0	0.4	-0.4	0.2
Social responses	0.8	1.0	1.8	-1.4	1.3	-0.7	-0.6	0.6	1.2
Social time	0.1	0.1	0.1	-0.3	0.4	0.0	-0.3	0.3	0.3
Soleus weight	1.2	3.4	5.7	-2.1	2.4	-2.0	1.6	-1.6	-1.1
Bone: stiffness	0.1	0.1	0.3	0.5	-0.6	0.5	-0.2	0.2	0.0
Tibialis anterior weight	0.4	1.4	2.7	-1.6	1.3	-1.3	-0.5	0.5	1.4
Time to tail flick, vehicle, before self-admin	1.6	1.7	3.9	-0.3	0.8	-0.6	2.0	-2.0	-1.2
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	0.1	0.4	0.0	0.9	-0.9	-0.7
Time to tail flick, test, before self-admin	0.6	0.6	1.5	0.1	-0.5	-0.1	-1.2	1.2	0.6
Time to tail flick, test, after self-admin	2.7	2.8	5.5	-2.0	2.4	-2.0	1.2	-1.2	-0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.2	-0.4	0.4	0.1	-0.1	-0.4
Delta time to tail flick, test, before/after SA	1.0	1.0	2.4	-1.1	1.5	-0.7	1.0	-1.0	-0.0
Tibia length	0.6	1.7	3.3	-0.4	1.3	-0.5	1.5	-1.5	-1.8
Ambulatory time before self-admin	0.1	0.2	0.3	-0.4	0.2	-0.4	-0.5	0.5	0.6
Ambulatory time after self-admin	0.3	0.3	0.7	-0.2	0.4	-0.1	0.9	-0.9	-0.6
Bone: tissue strength	1.6	1.6	2.6	0.4	-1.2	1.1	-1.6	1.6	1.2
Total heroin consumption	0.1	0.1	0.4	-0.2	0.6	-0.2	0.3	-0.3	-0.1
Bone: trabecular number	0.0	0.0	0.1	0.0	0.2	-0.0	-0.1	0.1	-0.1
Bone: trabecular spacing	0.5	0.6	1.7	-1.3	0.8	-1.0	-0.1	0.1	0.5
Bone: trabecular thickness	0.8	1.0	2.0	0.9	-0.2	0.7	1.1	-1.1	-1.4
Bone: trabecular tissue density	0.9	1.3	2.8	1.2	-1.7	1.4	-0.8	0.8	0.6
Water consumed over 24 hours	1.2	1.6	3.8	-0.6	-0.1	-0.3	-1.6	1.6	2.0
Number of responses in last shaping day	0.5	0.5	1.0	0.2	-0.2	0.6	1.0	-1.0	-0.8