Upk1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_039084978.2	0.04	0.02	1.9e-04	0.03	0.03	0.03	0.03	8.7e-04	4.5e-04	1.1e-03	2.1e-03
2	Brain	alternative TSS	NM_001108911.2	0.08	0.06	2.4e-04	0.04	0.04	0.03	0.04	2.4e-04	1.1e-04	5.6e-04	2.2e-04
3	Brain	alternative TSS	NM_001108911.2	0.09	0.06	8.4e-05	0.04	0.05	0.04	0.04	1.2e-04	2.8e-05	6.1e-05	9.0e-05
4	Brain	gene expression	Upk1a	0.07	0.04	6.0e-05	0.02	0.03	0.02	0.02	6.9e-03	2.2e-03	5.1e-03	2.3e-03
5	Brain	alternative TSS	XM_039084978.2	0.09	0.05	4.3e-07	0.07	0.06	0.05	0.06	6.4e-07	1.0e-06	1.7e-05	2.1e-06
6	Brain	alternative TSS	XM_063269116.1	0.08	0.04	2.1e-06	0.07	0.06	0.05	0.05	4.8e-07	3.4e-06	1.1e-05	8.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	1.2	-1.1	0.5	0.4	0.5	-0.7	-0.7
Area under the delay curve	0.9	1.1	1.4	-0.7	1.0	1.0	1.0	-1.2	-1.2
BMI with tail	0.1	0.2	0.7	0.3	0.2	0.2	0.1	-0.8	-0.8
BMI without tail	0.5	1.4	2.1	-1.0	1.1	1.1	1.1	-1.4	-1.4
Body weight	2.2	9.6	15.8	-4.0	2.8	2.6	3.1	-2.9	-2.9
Weight adjusted by age	0.1	0.1	0.2	-0.5	0.4	0.3	0.4	-0.3	-0.3
Bone surface	1.8	3.2	3.5	-1.9	1.8	1.8	1.7	-1.8	-1.8
Bone volume	1.7	3.0	3.7	-1.9	1.7	1.6	1.6	-1.8	-1.8
Breakpoint value in progressive ratio session	1.1	1.3	1.5	-1.1	1.2	1.2	1.2	-1.1	-1.1
Number of licking bursts	0.5	0.8	3.5	1.9	-0.5	-0.3	-0.9	0.3	0.3
Context. condit. distance diff. score	0.4	0.4	0.9	-0.2	0.9	0.9	0.7	-0.5	-0.5
Locomotion velocity, session 1	0.5	0.5	1.0	0.7	-0.8	-0.8	-1.0	0.4	0.4
Locomotion distance, session 1	3.0	3.8	6.4	-1.1	1.8	1.8	1.4	-2.5	-2.5
Locomotion velocity, session 2	0.3	0.4	0.9	1.0	-0.6	-0.5	-0.8	-0.1	-0.1
Locomotion distance, session 2	1.3	1.8	4.4	0.9	0.7	0.8	-0.1	-2.1	-2.1
Locomotion velocity, session 3	0.2	0.3	0.7	0.3	0.3	0.3	-0.1	-0.8	-0.8
Locomotion distance, session 3	8.9	9.7	13.0	-2.2	3.1	3.1	2.8	-3.6	-3.6
Stereotopy head waving bouts, day 3	3.9	4.5	5.9	1.2	-2.2	-2.3	-1.9	2.4	2.4
Stereotopy head waving duration, day 3	5.7	6.8	8.8	1.7	-2.7	-2.7	-2.4	3.0	3.0
Locomotion velocity, session 7	1.9	2.1	2.8	-0.9	1.5	1.5	1.2	-1.7	-1.7
Locomotion distance, session 7	0.9	1.1	1.4	-0.7	1.1	1.1	0.8	-1.2	-1.2
Stereotopy head waving bouts, day 7	0.5	0.5	2.0	1.4	-0.5	-0.4	-0.7	0.4	0.4
Stereotopy head waving duration, day 7	1.5	1.9	3.2	1.8	-1.3	-1.3	-1.4	1.1	1.1
Locomotion velocity, session 8	0.7	0.8	3.6	1.9	-0.5	-0.4	-1.0	0.0	0.0
Locomotion distance, session 8	1.2	1.8	3.0	0.4	1.4	1.5	0.7	-1.7	-1.7
Degree of sensitization distance	2.5	2.6	4.5	0.9	-1.4	-1.4	-1.3	2.1	2.1
Degree of sensitization stereotypy	0.2	0.2	1.2	1.1	0.1	0.2	-0.1	-0.2	-0.2
Conditioned locomotion	0.3	0.3	0.8	0.9	-0.6	-0.6	-0.5	0.0	0.0
Cocaine response after cond. corrected	1.7	2.1	2.8	0.5	-1.5	-1.6	-1.2	1.7	1.7
Cocaine response after cond. not corrected	2.4	2.8	4.4	0.5	-1.7	-1.8	-1.3	2.1	2.1
Cocaine response before conditioning	0.7	0.8	1.5	-1.2	1.1	1.1	1.0	-0.2	-0.2
Saline control response	0.3	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.6	0.6
Bone: connectivity density	0.3	0.5	0.6	-0.7	0.6	0.6	0.5	-0.8	-0.8
Bone: cortical apparent density	0.4	0.5	1.5	1.2	-0.6	-0.5	-0.9	-0.0	-0.0
Bone: cortical area	0.8	1.2	2.7	-1.6	1.0	0.9	1.1	-0.9	-0.9
Bone: cortical porosity	0.2	0.2	0.8	0.9	0.3	0.4	0.1	-0.4	-0.4
Bone: cortical porosity	0.3	0.3	1.3	1.1	0.3	0.4	-0.1	-0.4	-0.4
Bone: cortical thickness	0.1	0.2	0.9	-1.0	0.2	0.1	0.4	-0.4	-0.4
Bone: cortical thickness	0.5	0.6	1.0	0.8	-0.9	-0.9	-1.0	0.5	0.5
Bone: cortical tissue density	0.4	0.5	1.7	1.3	-0.5	-0.5	-0.9	-0.0	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.4	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.2	0.7	-1.5	-1.5	-1.2	0.9	0.9
Condit. Reinf. active responses	0.6	0.7	2.5	1.6	-0.7	-0.6	-1.0	-0.2	-0.2
Condit. Reinf. inactive responses	0.5	0.6	2.0	1.4	0.2	0.4	-0.3	-0.9	-0.9
Incentive salience index mean	0.1	0.2	0.3	0.4	-0.0	-0.0	-0.2	-0.6	-0.6
Condit. Reinf. lever presses	0.2	0.3	0.6	0.0	0.4	0.5	0.3	-0.8	-0.8
Condit. Reinf. active minus inactive responses	0.7	0.9	1.4	-1.2	0.9	0.9	0.9	-1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.4	0.2	0.2
Condit. Reinf. active responses	2.8	3.9	4.6	-2.2	2.0	1.9	1.9	-2.0	-2.0
Condit. Reinf. inactive responses	4.5	5.9	6.9	-2.4	2.5	2.5	2.6	-2.3	-2.3
Condit. Reinf. lever presses	4.2	5.8	10.1	-3.2	2.4	2.3	2.5	-1.9	-1.9
Condit. Reinf. lever reinforcers received	3.9	5.4	5.6	-2.3	2.4	2.3	2.3	-2.3	-2.3
Conditioned reinforcement - actives	0.4	0.6	1.1	1.1	-0.7	-0.7	-1.0	0.6	0.6
Conditioned reinforcement - inactives	1.4	2.1	3.0	-0.4	1.6	1.7	1.3	-1.6	-1.6
Conditioned locomotion	1.3	1.6	3.5	1.9	-1.2	-1.1	-1.4	0.9	0.9
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.2	0.1	0.2	0.3	0.2	0.2
Patch foraging indifference point AUC	0.5	0.7	1.0	1.0	-0.9	-0.8	-0.9	0.6	0.6
Delay disc. indifference point, 0s delay	2.7	3.0	4.5	-0.7	1.8	1.8	1.5	-2.1	-2.1
Delay disc. indifference point, 16s delay	1.1	1.2	1.6	-0.8	1.0	1.0	1.2	-1.3	-1.3
Delay disc. indifference point, 2s delay	2.7	3.0	3.7	-1.3	1.8	1.8	1.6	-1.9	-1.9
Delay disc. indifference point, 24s delay	2.1	2.4	2.8	-1.6	1.5	1.5	1.7	-1.5	-1.5
Delay disc. indifference point, 4s delay	0.3	0.4	0.5	0.0	0.7	0.7	0.5	-0.7	-0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.4	0.4	0.4	0.5	-0.4	-0.4
Indifference point function ln k	0.4	0.7	1.3	-0.7	0.8	0.7	0.6	-1.1	-1.1
Indifference point function log k	0.4	0.7	1.3	-0.7	0.8	0.7	0.6	-1.1	-1.1
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.4	0.3	0.3	0.4	0.0	0.0
Patch foraging total patch changes 12 sec	0.4	0.5	0.9	0.4	-0.7	-0.7	-0.6	0.9	0.9
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.2	0.2	0.2	0.2	0.1	0.1
Patch foraging total patch changes 24 sec	0.8	1.3	1.9	-1.0	1.2	1.2	1.4	-0.9	-0.9
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.1	-0.4	-0.3	-0.2	0.6	0.6
Patch foraging time to switch 0 sec	1.5	3.1	4.1	1.3	-1.8	-1.8	-1.4	2.0	2.0
Patch foraging water rate 0 sec	0.1	0.2	0.5	0.7	0.1	0.1	-0.5	-0.5	-0.5
Patch foraging water rate 12 sec	1.3	2.8	4.0	-1.2	2.0	2.0	1.6	-1.6	-1.6
Patch foraging water rate 18 sec	0.0	0.1	0.1	0.3	0.1	0.1	-0.2	-0.4	-0.4
Patch foraging water rate 24 sec	3.4	4.8	8.2	-0.5	2.2	2.3	1.5	-2.9	-2.9
Patch foraging water rate 6 sec	3.6	5.2	6.6	-1.6	2.6	2.6	2.1	-2.4	-2.4
Seeking ratio, delayed vs. immediate footshock	3.7	4.6	5.3	-1.6	2.3	2.3	2.1	-2.2	-2.2
Distance traveled before self-admin	0.1	0.1	0.1	-0.1	0.4	0.4	0.3	-0.3	-0.3
Distance traveled after self-admin	1.1	1.4	2.4	-1.6	1.2	1.1	1.4	-0.8	-0.8
Extensor digitorum longus weight	0.4	1.7	3.1	0.7	-1.7	-1.8	-1.5	0.9	0.9
Bone: elastic displacement	0.4	0.4	0.9	0.1	-0.6	-0.6	-0.4	0.9	0.9
Bone: elastic work	0.7	0.8	2.3	-1.5	0.8	0.7	1.1	-0.5	-0.5
Bone: endosteal estimation	0.9	1.9	3.4	-1.8	1.4	1.4	1.5	-1.0	-1.0
Bone: endosteal perimeter	1.1	2.3	2.8	-1.7	1.6	1.6	1.6	-1.3	-1.3
Epididymis fat weight	0.1	0.5	1.0	-0.4	0.5	0.5	0.3	-1.0	-1.0
Delta time in closed arm before/after self-admin	0.7	0.7	1.4	-1.2	0.8	0.7	0.9	-0.7	-0.7
Delta time in open arm before/after self-admin	0.6	0.6	1.0	0.7	-0.7	-0.7	-0.7	1.0	1.0
Diff in mean of infusions in LGA sessions	0.2	0.3	0.8	0.9	-0.6	-0.5	-0.5	0.0	0.0
Delay discount exponential model param	0.9	1.0	1.2	0.8	-0.9	-0.9	-1.0	1.1	1.1
Extinction: sum of active levers before priming	0.8	0.9	3.6	-1.9	0.6	0.4	1.0	-0.3	-0.3
Active lever presses in extinction session 6	1.1	1.1	1.8	-0.7	-0.9	-1.1	-0.6	1.3	1.3
Bone: final force	1.2	1.9	3.4	-1.8	1.2	1.1	1.4	-1.3	-1.3
Bone: final moment	1.5	2.4	4.6	-2.1	1.4	1.3	1.6	-1.4	-1.4
Food consumed during 24 hour testing period	1.9	2.7	3.5	-1.1	1.7	1.7	1.6	-1.9	-1.9
Glucose	0.7	1.0	1.3	0.7	-1.1	-1.1	-1.1	1.0	1.0
Heart weight	0.4	0.6	0.9	-0.4	0.9	1.0	0.6	-0.7	-0.7
Delay discount hyperbolic model param	0.8	0.9	1.1	0.7	-0.9	-0.9	-0.9	1.1	1.1
Intermittent access intake day 1-15 change	0.8	1.7	3.3	-1.8	1.2	1.1	1.5	-0.9	-0.9
Intermittent access intake escalation	0.5	1.1	2.6	-1.6	1.0	0.9	1.2	-0.7	-0.7
Intermittent access intake escalation 2	0.3	0.3	1.3	-1.1	0.3	0.2	0.6	0.1	0.1
Intermitt. access day 1 inactive lever presses	1.4	5.1	6.7	-2.4	2.3	2.3	2.6	-1.9	-1.9
Intermitt. access day 15 inactive lever presses	1.5	3.0	3.5	-1.3	1.8	1.9	1.8	-1.7	-1.7
Intermitt. access escalation Index	0.4	0.5	0.9	0.2	0.7	0.8	0.5	-0.9	-0.9
Intermittent access day 1 total infusions	0.4	0.6	2.0	1.4	0.5	0.6	-0.1	-0.7	-0.7
Intermittent access day 15 total infusions	0.7	1.0	1.5	-0.1	1.1	1.2	0.8	-1.1	-1.1
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.1	0.3	1.0	1.1	0.6	-1.1	-1.1
Intermittent access total infusions	0.6	0.7	1.1	0.6	0.8	0.9	0.5	-1.0	-1.0
Intermittent access day 1 locomotion	1.1	1.4	2.2	0.8	1.1	1.3	0.6	-1.5	-1.5
Intermittent access day 15 total locomotion	0.8	1.4	2.0	-0.2	1.3	1.4	1.0	-1.3	-1.3
Intermittent access total locomotion	0.4	0.4	1.0	1.0	0.3	0.5	-0.0	-0.8	-0.8
Intermittent access standard deviation	2.1	4.4	5.9	-2.3	2.2	2.1	2.4	-1.7	-1.7
Left kidney weight	1.2	5.7	12.1	-3.5	2.2	2.0	2.5	-1.9	-1.9
Right kidney weight	1.2	5.4	13.4	-3.7	2.0	1.8	2.4	-1.7	-1.7
Cocaine induced anxiety	0.0	0.1	0.1	-0.0	-0.3	-0.4	-0.3	0.2	0.2
Post-drug Anxiety	0.1	0.1	0.2	0.3	-0.5	-0.5	-0.2	0.3	0.3
Baseline Anxiety	0.3	0.3	0.5	-0.1	0.6	0.6	0.7	-0.5	-0.5
Tail length	3.1	12.3	21.5	-4.6	3.4	3.2	3.7	-2.9	-2.9
Length with tail	4.2	18.3	32.9	-5.7	4.1	3.9	4.6	-3.4	-3.4
Length without tail	2.2	6.9	12.1	-3.5	2.5	2.4	2.6	-2.3	-2.3
Times rat made contact with spout	0.7	0.8	1.1	0.7	-0.9	-0.9	-1.1	0.8	0.8
Lifetime Intake	0.3	0.3	0.6	0.8	0.5	0.6	0.1	-0.6	-0.6
Liver weight, left	0.5	0.8	0.9	0.9	-0.8	-0.8	-0.9	1.0	1.0
Liver weight, right	0.3	0.6	1.4	0.8	-0.8	-0.8	-1.2	0.4	0.4
Locomotor activity	2.3	3.5	4.7	1.2	-1.8	-1.8	-1.9	2.2	2.2
Locomotor testing distance	1.5	2.7	3.9	1.3	-1.4	-1.4	-1.6	2.0	2.0
Locomotor testing rearing	0.9	1.7	2.8	1.7	-1.1	-1.0	-1.6	1.2	1.2
Locomotion in novel chamber	1.1	1.4	1.7	0.8	-1.3	-1.3	-1.1	1.2	1.2
Locomotion in novel chamber post-restriction	0.2	0.3	0.4	0.4	-0.6	-0.6	-0.5	0.7	0.7
Fecal boli incidents, locomotor time 1	3.1	4.5	5.2	2.3	-2.3	-2.2	-2.3	1.8	1.8
Change in fecal boli incidents, locomotor task	1.5	1.4	2.1	0.2	-1.3	-1.3	-1.0	1.5	1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.2	0.2
Bouts of movement, locomotor time 1	2.8	3.2	4.1	-1.0	2.0	2.0	1.6	-1.9	-1.9
Total resting periods, locomotor time 1	1.8	2.0	2.6	-0.7	1.6	1.6	1.3	-1.5	-1.5
Rest time, locomotor task time 1	2.0	2.5	3.2	1.8	-1.7	-1.6	-1.7	1.3	1.3
Distance moved, locomotor task time 1	0.4	0.5	0.7	-0.5	0.8	0.8	0.6	-0.8	-0.8
Vertical activity count, locomotor time 1	1.3	3.1	3.6	-1.8	1.9	1.8	1.9	-1.5	-1.5
Time >=10cm from walls, locomotor time 2	0.6	0.9	2.0	1.4	-1.0	-0.9	-1.1	0.5	0.5
Bouts of movement, locomotor time 2	0.1	0.2	0.3	-0.0	0.5	0.5	0.3	-0.4	-0.4
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	0.1	0.2	-0.0	0.0	0.0
Rest time, locomotor task time 2	0.8	1.1	1.1	1.0	-1.0	-1.0	-1.0	1.1	1.1
Distance moved, locomotor task time 2	0.5	0.6	1.0	-0.2	0.8	0.9	0.5	-1.0	-1.0
Vertical activity count, locomotor time 2	1.7	2.4	2.7	-1.3	1.6	1.6	1.5	-1.7	-1.7
Light reinforcement 1	0.1	0.2	0.4	0.2	0.5	0.5	0.2	-0.6	-0.6
Light reinforcement 2	1.0	1.5	3.1	1.8	-1.3	-1.2	-1.6	0.5	0.5
Bone: marrow area	0.8	1.7	3.3	-1.8	1.3	1.3	1.4	-0.9	-0.9
Bone: maximum diameter	0.7	1.3	2.8	-1.7	1.1	1.0	1.3	-0.8	-0.8
Bone: maximum force	2.2	3.9	6.1	-2.5	1.9	1.7	2.0	-1.9	-1.9
Bone: maximum moment	2.6	4.5	7.3	-2.7	2.0	1.9	2.1	-2.0	-2.0
Mean time between licks in bursts	0.4	0.9	1.6	-0.3	0.9	0.9	0.6	-1.3	-1.3
Mean num. licks in bursts	0.2	0.3	1.4	-1.2	-0.1	-0.2	0.1	-0.0	-0.0
Cd content in liver	0.2	0.2	0.3	0.4	-0.5	-0.5	-0.3	0.6	0.6
Co content in liver	1.3	1.5	1.9	0.8	-1.3	-1.3	-1.1	1.4	1.4
Cu content in liver	1.0	1.2	1.7	-1.3	1.1	1.0	1.1	-1.0	-1.0
Fe content in liver	0.7	0.9	1.6	0.8	-0.7	-0.7	-0.8	1.3	1.3
K content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.2	0.2
Mg content in liver	1.7	1.7	2.1	0.9	-1.4	-1.4	-1.4	1.3	1.3
Mn content in liver	3.6	4.0	5.5	1.2	-2.0	-2.1	-1.8	2.3	2.3
Na content in liver	0.5	0.5	0.8	-0.9	0.8	0.8	0.9	-0.1	-0.1
Rb content in liver	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.1	0.4	0.4
Se content in liver	6.6	7.8	9.8	2.8	-2.9	-2.9	-3.1	2.5	2.5
Sr content in liver	1.6	1.4	2.4	0.7	-1.1	-1.0	-1.0	1.6	1.6
Zn content in liver	2.9	3.2	3.9	1.7	-2.0	-2.0	-2.0	1.5	1.5
Bone: minimum diameter	3.3	6.1	7.0	-2.6	2.6	2.5	2.7	-2.2	-2.2
Time in familiar zone, hab. session 1	0.1	0.1	0.4	-0.7	-0.3	-0.4	-0.3	-0.1	-0.1
Time in novel zone, hab. session 1	0.3	0.3	1.4	1.2	-0.1	-0.0	-0.2	0.2	0.2
Total zone transitions, hab. session 1	0.7	0.9	1.7	-0.1	1.0	1.0	0.6	-1.3	-1.3
Total locomotion distance, hab. session 1	0.7	1.0	1.4	-0.9	1.2	1.2	1.1	-0.8	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.6	0.6	0.7	0.6	-0.3	-0.3
Time in familiar zone, hab. session 2	0.8	0.8	1.7	-0.9	-0.5	-0.6	0.1	1.3	1.3
Time in novel zone, hab. session 2	0.3	0.3	0.7	0.8	0.0	0.1	-0.4	-0.8	-0.8
Total zone transitions, hab. session 2	0.7	0.9	3.6	1.9	-0.5	-0.4	-1.2	-0.3	-0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.5	0.5	0.6	0.2	-0.5	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.6	0.2	0.3	-0.0	-0.3	-0.3
Novel to familiar place preference ratio	0.2	0.3	0.3	-0.5	0.5	0.5	0.6	-0.5	-0.5
Novelty place preference	0.2	0.2	0.3	-0.4	0.6	0.6	0.6	-0.4	-0.4
Time in novel zone, NPP test	0.2	0.2	0.3	-0.2	0.5	0.5	0.4	-0.4	-0.4
Total zone transitions, NPP test	0.5	0.7	2.0	0.1	0.5	0.5	0.1	-1.4	-1.4
Total locomotion distance, NPP test	1.5	2.1	2.9	-1.7	1.4	1.4	1.4	-1.3	-1.3
Locomotion velocity, NPP test	1.2	1.7	2.9	-1.7	1.3	1.2	1.4	-1.1	-1.1
Intraocular pressure	0.1	0.2	0.4	0.2	-0.1	-0.0	0.2	0.6	0.6
Delta distance traveled before/after self-admin	1.4	1.5	3.0	-1.7	1.1	1.1	1.4	-0.9	-0.9
Delta ambulatory time before/after self-admin	1.7	2.1	3.2	-1.8	1.4	1.3	1.6	-1.2	-1.2
Parametrial fat weight	2.0	4.7	6.7	0.7	-2.5	-2.6	-2.1	2.3	2.3
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.4	-0.3	-0.4	-0.0	0.5	0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	1.3	1.1	-0.3	-0.2	-0.8	-0.0	-0.0
Pavlov. Cond. change in total contacts	0.7	0.8	1.4	0.6	0.8	0.9	0.3	-1.2	-1.2
Pavlov. Cond. index score	0.2	0.2	0.9	0.9	-0.1	0.0	-0.6	-0.3	-0.3
Pavlov. Cond. latency score	0.2	0.2	0.4	0.7	0.2	0.3	-0.2	-0.5	-0.5
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.1	0.5	0.5	0.3	-0.5	-0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.8	-0.9	-0.1	-0.2	0.5	0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.8	0.9	-0.7	-0.7	-0.9	0.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.2	1.1	-0.1	-0.0	-0.7	-0.3	-0.3
Pavlov. Cond. response bias	0.2	0.2	0.7	0.8	-0.3	-0.3	-0.8	0.1	0.1
Pavlov. Cond. lever latency	4.9	6.7	8.0	2.8	-2.6	-2.5	-2.6	2.5	2.5
Pavlov. Cond. magazine entry latency	2.0	2.4	3.9	-2.0	1.7	1.6	1.8	-0.9	-0.9
Pavlov. Cond. change in total contacts	6.2	9.9	13.1	-3.6	3.3	3.2	3.5	-2.5	-2.5
Pavlov. Cond. index score	4.5	6.1	8.5	-2.9	2.6	2.5	2.6	-2.0	-2.0
Pavlov. Cond. latency score	4.1	5.4	7.3	-2.7	2.5	2.4	2.5	-1.8	-1.8
Pavlov. Cond. lever contacts	5.3	7.3	8.7	-3.0	2.7	2.7	2.8	-2.6	-2.6
Pavlov. Cond. magazine entry number	3.2	4.0	6.0	2.4	-2.2	-2.1	-2.1	1.5	1.5
Pavlov. Cond. intertrial magazine entries	0.9	1.3	1.4	1.2	-1.2	-1.1	-1.0	1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	3.9	5.2	7.8	-2.8	2.4	2.4	2.5	-1.7	-1.7
Pavlov. Cond. response bias	6.7	9.1	10.6	-3.3	3.1	3.1	3.1	-2.8	-2.8
Time in closed arm before self-admin	0.2	0.3	1.5	1.2	-0.1	-0.0	-0.4	-0.1	-0.1
Time in closed arm after self-admin	0.7	0.7	1.3	-0.2	0.7	0.8	0.7	-1.1	-1.1
Time in open arm before self-admin	1.0	1.1	4.0	-2.0	0.8	0.6	1.1	-0.2	-0.2
Time in open arm after self-admin	0.3	0.3	0.8	-0.9	0.1	0.0	0.2	0.7	0.7
Bone: periosteal estimation	1.2	2.6	5.0	-2.2	1.6	1.5	1.7	-1.2	-1.2
Bone: periosteal perimeter	0.4	0.7	1.9	-1.4	0.8	0.7	0.9	-0.4	-0.4
Bone: post-yield work	3.4	5.0	5.7	-2.0	2.4	2.4	2.3	-2.1	-2.1
Progressive ratio test 1 active lever presses	0.9	1.1	1.5	-0.1	1.2	1.2	0.9	-1.1	-1.1
Progressive ratio test 1 breakpoint	1.0	1.3	1.8	-0.2	1.3	1.3	1.0	-1.2	-1.2
Progressive ratio test 1 inactive lever presses	3.1	4.5	5.9	-0.6	2.3	2.4	1.9	-2.4	-2.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.4	0.3	0.4	-0.0	-0.4	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.5	0.3	0.3	-0.1	-0.3	-0.3
Progressive ratio test 2 inactive lever presses	2.1	3.4	4.7	-0.7	1.9	2.0	1.7	-2.2	-2.2
Incentive Sensitization - Responses	0.1	0.1	0.4	0.7	-0.1	-0.0	-0.4	-0.1	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.6	-0.0	0.0	-0.4	-0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	-0.4	-0.4	-0.3	0.4	0.4
Progressive ratio	0.0	0.0	0.1	0.3	0.0	0.1	-0.1	-0.0	-0.0
Food seeking constrained by brief footshock	1.1	1.4	2.4	-1.6	1.2	1.2	1.3	-0.8	-0.8
Seeking ratio, punishment vs. effort	0.5	0.8	1.0	-0.9	1.0	1.0	0.9	-0.7	-0.7
Retroperitoneal fat weight	2.4	10.3	13.6	1.9	-3.6	-3.7	-3.5	3.1	3.1
Reaction time number correct	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.2	-0.2
Reaction time mean minus median	0.1	0.2	0.6	-0.8	0.2	0.2	0.6	-0.1	-0.1
Reaction time mean minus median AUC	0.2	0.4	1.5	-1.2	0.4	0.4	0.8	-0.1	-0.1
Reaction time num false alarms	0.6	0.8	1.1	1.0	-0.8	-0.7	-0.7	1.0	1.0
Reaction time num false alarms AUC	1.0	1.6	2.4	1.3	-1.0	-1.0	-0.9	1.5	1.5
Reaction time trials correct on left	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.2	-0.2
Reaction time trials on left	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.2	-0.2
Reaction time mean	0.3	0.4	0.5	-0.7	0.7	0.7	0.7	-0.6	-0.6
Reaction time mean AUC	0.1	0.2	0.2	-0.5	0.4	0.4	0.5	-0.3	-0.3
Median of all reaction times	0.2	0.2	0.3	-0.2	0.5	0.5	0.4	-0.5	-0.5
Reaction time omissions	0.2	0.3	0.5	0.1	-0.6	-0.6	-0.5	0.7	0.7
Reaction time false alarm rate	0.7	1.0	1.7	1.0	-0.8	-0.7	-0.6	1.3	1.3
Reaction time premature initiation rate	0.2	0.3	0.4	0.0	0.6	0.7	0.6	-0.5	-0.5
Reaction time premature initiations	0.2	0.3	0.4	0.0	0.6	0.7	0.5	-0.6	-0.6
Std. dev. reaction times	0.5	0.9	1.4	-1.2	1.0	1.0	1.2	-0.7	-0.7
Reaction time trials completed	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.2	-0.2
Reaction time trials AUC	0.0	0.1	0.2	0.1	-0.2	-0.3	-0.4	0.1	0.1
Run reversals in cocaine runway, females	1.6	1.6	1.9	-1.2	1.4	1.4	1.4	-1.1	-1.1
Run reversals in cocaine runway, males	3.8	3.8	5.2	0.6	-2.1	-2.2	-1.8	2.3	2.3
Latency to leave start box in cocaine runway	1.1	1.2	1.6	-0.8	1.3	1.3	1.2	-1.0	-1.0
Latency to leave start box in cocaine runway, F	1.0	1.2	1.5	-0.5	1.2	1.2	0.9	-1.2	-1.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.2	0.3	0.4	0.5	-0.0	-0.0
Std. dev. time between licks in bursts	0.8	1.0	1.6	-0.3	1.2	1.3	1.1	-1.0	-1.0
Total sessions with >9 infusions	0.5	0.7	1.4	1.2	-0.6	-0.6	-1.0	0.6	0.6
Short access day 1 total inactive lever presses	4.9	6.5	8.2	-1.1	2.8	2.9	2.3	-2.8	-2.8
Short access day 10 total inactive lever presses	2.8	6.8	7.4	-2.1	2.7	2.7	2.6	-2.7	-2.7
Short access day 1 total infusions	0.2	0.2	0.5	0.0	0.7	0.7	0.3	-0.4	-0.4
Short access day 10 total infusions	0.1	0.1	0.5	0.7	-0.1	-0.1	-0.3	0.0	0.0
Short access total infusions	0.2	0.3	1.0	1.0	-0.3	-0.2	-0.7	0.3	0.3
Short access day 1 locomotion	0.2	0.3	0.8	0.9	-0.4	-0.4	-0.6	0.1	0.1
Short access day 10 total locomotion	0.8	1.5	2.0	-0.5	1.3	1.4	1.2	-1.4	-1.4
Short access total locomotion	0.3	0.3	1.5	1.2	-0.3	-0.2	-0.6	0.0	0.0
One hour access (0.3 mA shock)	3.0	3.4	5.0	-0.9	2.2	2.2	1.8	-1.9	-1.9
Compulsive drug intake	0.8	0.9	1.5	-0.2	1.2	1.2	0.8	-1.0	-1.0
One hour access (shock baseline)	0.4	0.5	0.8	-0.1	0.8	0.9	0.6	-0.8	-0.8
Social response proportion	0.9	1.0	1.9	-1.4	0.8	0.7	1.1	-1.0	-1.0
Social responses	0.1	0.1	0.4	-0.6	0.2	0.1	0.4	-0.0	-0.0
Social time	3.3	4.5	5.1	-2.1	2.3	2.2	2.2	-2.0	-2.0
Soleus weight	0.1	0.3	0.5	0.3	-0.7	-0.7	-0.6	0.5	0.5
Bone: stiffness	1.6	2.6	3.4	-1.7	1.4	1.3	1.4	-1.8	-1.8
Tibialis anterior weight	0.4	1.5	2.7	0.3	-1.5	-1.6	-1.3	1.1	1.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.4	0.2	0.3	-0.1	-0.3	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.0	0.4	0.4
Time to tail flick, test, before self-admin	2.6	2.7	4.0	-0.5	1.7	1.8	1.3	-2.0	-2.0
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.4	-0.2	-0.2	-0.3	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.6	0.1	0.1	0.5	0.0	0.0
Delta time to tail flick, test, before/after SA	3.8	3.9	4.7	1.2	-2.1	-2.2	-1.9	2.2	2.2
Tibia length	2.5	7.0	9.1	-3.0	2.6	2.4	2.5	-2.7	-2.7
Ambulatory time before self-admin	0.1	0.1	0.1	-0.1	0.4	0.4	0.4	-0.2	-0.2
Ambulatory time after self-admin	2.9	3.4	5.0	-2.2	1.9	1.8	2.1	-1.5	-1.5
Bone: tissue strength	4.1	4.1	5.2	-2.1	2.1	2.1	2.3	-1.7	-1.7
Total heroin consumption	1.1	1.3	1.5	-0.7	1.2	1.2	1.1	-1.2	-1.2
Bone: trabecular number	1.4	2.4	3.0	-1.7	1.4	1.3	1.4	-1.7	-1.7
Bone: trabecular spacing	0.6	0.9	2.2	-0.2	-0.5	-0.6	-0.2	1.5	1.5
Bone: trabecular thickness	0.2	0.3	0.6	-0.2	0.4	0.4	0.2	-0.7	-0.7
Bone: trabecular tissue density	4.5	6.6	7.8	1.9	-2.6	-2.6	-2.6	2.8	2.8
Water consumed over 24 hours	0.3	0.5	0.7	-0.9	0.6	0.6	0.5	-0.7	-0.7
Number of responses in last shaping day	0.6	0.6	1.2	-0.4	1.1	1.1	0.6	-0.7	-0.7