Hub : Genes

Unc80

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Unc80 0.31 0.11 0.0e+00 0.18 0.18 0.19 0.18 4.0e-20 4.0e-20 7.0e-21 1.0e-19
2 BLA intron excision ratio chr9_68163137_68165373 0.09 0.04 1.5e-03 0.06 0.05 0.03 0.05 4.3e-04 7.3e-04 8.5e-03 1.6e-03
3 PL gene expression Unc80 0.04 0.02 2.6e-03 0.01 0.01 0.01 0.01 9.2e-03 1.9e-02 2.2e-02 4.1e-02
4 pVTA mRNA stability Unc80 0.06 0.03 8.2e-03 0.04 0.04 0.01 0.02 1.2e-02 1.2e-02 1.0e-01 4.8e-02
5 Liver gene expression Unc80 0.19 0.07 0.0e+00 0.11 0.12 0.11 0.11 2.0e-12 1.6e-13 5.9e-12 5.0e-12
6 Eye intron excision ratio chr9_68017045_68024741 0.37 0.15 6.4e-03 0.03 0.12 0.05 0.07 1.0e-01 5.9e-03 6.5e-02 2.8e-02
7 Brain gene expression Unc80 0.06 0.03 8.1e-05 0.05 0.06 0.05 0.05 2.4e-05 7.9e-06 1.1e-05 1.1e-05
8 pVTA intron excision ratio chr9_68184737_68185313 0.14 0.09 6.1e-03 -0 0.03 0.01 -0 6.0e-01 2.0e-02 1.7e-01 4.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.20.50.7-0.20.60.0-0.10.70.2-0.2
Area under the delay curve0.30.30.7-0.80.3-0.6-0.4-0.3-0.3-0.1-0.9
BMI with tail3.310.720.0-4.34.5-4.2-3.1-1.4-3.01.2-2.7
BMI without tail1.22.65.1-1.72.3-1.9-1.1-0.5-1.80.9-1.8
Body weight0.41.65.9-0.00.6-0.51.00.9-1.32.4-1.7
Weight adjusted by age0.20.30.8-0.90.5-0.7-0.40.0-0.40.4-0.2
Bone surface0.30.51.50.7-0.30.60.71.1-0.11.2-0.1
Bone volume0.50.92.21.5-1.01.30.90.60.90.40.1
Breakpoint value in progressive ratio session0.80.92.10.7-1.30.8-0.2-0.81.4-0.90.8
Number of licking bursts0.40.51.4-0.40.6-0.70.00.4-0.81.2-0.7
Context. condit. distance diff. score0.60.71.6-0.10.8-0.3-1.2-1.30.8-0.4-0.9
Locomotion velocity, session 10.91.01.80.9-1.11.21.31.1-0.4-0.51.1
Locomotion distance, session 10.10.10.4-0.20.3-0.1-0.2-0.1-0.4-0.7-0.3
Locomotion velocity, session 21.72.05.6-0.10.4-0.41.21.9-2.12.4-1.0
Locomotion distance, session 20.40.62.4-0.80.8-0.60.10.3-1.60.3-0.6
Locomotion velocity, session 31.41.64.6-0.60.5-0.4-1.8-2.11.5-1.5-0.3
Locomotion distance, session 31.21.32.91.5-1.51.71.00.80.8-0.40.6
Stereotopy head waving bouts, day 32.73.25.7-2.31.8-1.8-2.4-2.20.1-1.60.9
Stereotopy head waving duration, day 33.03.67.3-2.32.1-2.0-2.5-2.70.1-1.30.3
Locomotion velocity, session 70.50.52.90.30.20.10.10.7-0.30.8-1.7
Locomotion distance, session 71.62.05.40.9-0.30.71.52.3-1.51.6-1.3
Stereotopy head waving bouts, day 70.10.20.3-0.40.5-0.5-0.5-0.40.10.2-0.5
Stereotopy head waving duration, day 71.82.14.4-1.31.4-1.6-1.9-2.10.6-0.4-1.6
Locomotion velocity, session 80.30.40.6-0.80.6-0.8-0.8-0.2-0.3-0.2-0.6
Locomotion distance, session 80.10.20.7-0.20.7-0.3-0.5-0.2-0.30.2-0.8
Degree of sensitization distance1.21.22.9-0.81.2-1.10.10.7-1.71.3-1.2
Degree of sensitization stereotypy0.50.62.6-0.40.6-0.7-0.20.1-0.40.9-1.6
Conditioned locomotion0.40.51.20.4-0.60.31.10.9-0.51.00.1
Cocaine response after cond. corrected0.50.61.00.9-0.91.00.80.50.2-0.30.9
Cocaine response after cond. not corrected1.01.12.11.4-1.31.41.00.80.7-0.10.8
Cocaine response before conditioning0.30.41.00.7-0.40.30.30.60.71.0-0.6
Saline control response0.70.91.8-1.21.2-1.1-0.40.2-1.31.0-0.1
Bone: connectivity density0.60.92.0-0.71.2-0.9-0.50.5-0.91.4-1.2
Bone: cortical apparent density2.12.85.3-2.32.2-2.0-1.30.3-2.21.0-0.7
Bone: cortical area0.91.44.11.0-0.90.81.62.0-0.81.10.2
Bone: cortical porosity5.15.610.43.2-3.13.02.51.02.0-0.12.0
Bone: cortical porosity5.86.411.53.4-3.33.22.81.21.90.12.3
Bone: cortical thickness0.81.24.60.4-0.30.21.12.1-1.41.2-0.5
Bone: cortical thickness0.70.81.31.0-1.11.10.50.60.9-0.51.0
Bone: cortical tissue density2.33.15.8-2.42.4-2.1-1.40.2-2.21.0-0.8
Condit. Reinf. active minus inactive responses1.11.23.31.0-1.01.21.11.2-0.00.41.8
Condit. Reinf. active-inactive response ratio0.20.31.40.3-0.30.60.20.10.1-0.21.2
Condit. Reinf. active responses1.41.72.71.3-1.31.41.51.7-0.00.81.6
Condit. Reinf. inactive responses0.81.02.10.9-1.00.81.41.4-0.40.70.7
Incentive salience index mean0.91.12.11.0-1.01.11.21.4-0.00.71.4
Condit. Reinf. lever presses0.30.41.00.6-0.80.60.71.00.30.60.6
Condit. Reinf. active minus inactive responses4.05.09.62.8-3.12.72.52.01.30.21.6
Condit. Reinf. active-inactive response ratio3.73.97.62.7-2.72.52.01.21.7-0.51.3
Condit. Reinf. active responses2.63.66.52.3-2.62.22.11.91.00.41.6
Condit. Reinf. inactive responses0.30.40.70.4-0.50.40.60.9-0.00.80.7
Condit. Reinf. lever presses0.60.81.80.7-1.00.90.00.11.3-0.81.3
Condit. Reinf. lever reinforcers received2.73.87.22.5-2.72.42.11.81.30.31.5
Conditioned reinforcement - actives0.40.41.0-0.50.6-0.90.20.3-1.00.6-0.3
Conditioned reinforcement - inactives0.91.12.40.9-1.51.21.51.00.1-0.10.8
Conditioned locomotion4.25.09.3-3.12.6-2.9-2.5-1.9-0.9-1.0-2.0
Patch foraging indifference point 0 sec0.91.44.2-1.00.7-1.10.41.3-2.01.70.1
Patch foraging indifference point AUC0.10.10.30.3-0.00.30.40.1-0.1-0.1-0.5
Delay disc. indifference point, 0s delay0.91.01.6-1.11.1-1.2-1.3-0.9-0.3-0.3-1.2
Delay disc. indifference point, 16s delay0.40.40.8-0.6-0.1-0.3-0.9-0.70.8-0.7-0.3
Delay disc. indifference point, 2s delay1.92.13.6-1.61.3-1.4-1.9-1.70.3-1.1-1.6
Delay disc. indifference point, 24s delay0.60.61.5-0.80.6-0.60.20.6-1.21.2-0.2
Delay disc. indifference point, 4s delay0.70.71.4-1.01.2-0.8-0.7-0.5-0.8-0.1-1.1
Delay disc. indifference point, 8s delay0.30.30.5-0.2-0.1-0.20.50.7-0.70.7-0.7
Indifference point function ln k0.91.33.2-1.51.1-1.4-1.8-1.20.4-0.3-0.1
Indifference point function log k0.91.33.2-1.51.1-1.4-1.8-1.20.4-0.3-0.1
Patch foraging total patch changes 0 sec0.71.13.1-1.00.6-1.00.31.1-1.81.40.3
Patch foraging total patch changes 12 sec0.00.00.1-0.00.1-0.00.10.2-0.4-0.10.1
Patch foraging total patch changes 18 sec0.60.83.3-0.70.7-0.70.20.8-1.80.9-0.5
Patch foraging total patch changes 24 sec0.00.10.2-0.20.1-0.2-0.10.3-0.2-0.20.4
Patch foraging total patch changes 6 sec1.01.43.5-1.11.5-1.2-0.10.6-1.91.5-0.9
Patch foraging time to switch 0 sec0.30.40.90.9-0.71.00.4-0.20.6-0.60.5
Patch foraging water rate 0 sec0.50.81.9-0.70.7-1.0-0.00.7-1.20.9-1.4
Patch foraging water rate 12 sec0.50.81.8-1.00.8-0.7-1.4-1.00.4-1.0-0.0
Patch foraging water rate 18 sec0.60.82.00.5-0.80.6-0.2-0.41.4-0.91.4
Patch foraging water rate 24 sec0.00.10.30.1-0.20.10.20.2-0.2-0.0-0.5
Patch foraging water rate 6 sec1.31.93.8-2.01.8-1.9-1.5-0.4-1.20.1-1.1
Seeking ratio, delayed vs. immediate footshock0.50.61.60.6-0.80.7-0.1-0.71.3-0.90.8
Distance traveled before self-admin0.50.52.20.7-0.70.6-0.1-0.51.5-0.50.3
Distance traveled after self-admin0.40.41.6-0.21.1-0.4-0.7-0.00.10.3-1.3
Extensor digitorum longus weight1.76.615.1-2.63.0-2.8-0.50.8-3.92.9-2.2
Bone: elastic displacement0.50.51.7-0.90.4-0.7-1.3-0.50.4-0.70.4
Bone: elastic work0.20.20.60.4-0.50.40.30.80.30.30.4
Bone: endosteal estimation0.91.93.71.9-1.81.71.30.21.5-0.21.1
Bone: endosteal perimeter0.40.91.71.1-1.21.10.6-0.31.3-0.31.0
Epididymis fat weight1.94.316.20.40.4-0.41.92.5-2.14.0-1.9
Delta time in closed arm before/after self-admin1.31.24.1-0.60.5-0.90.51.0-1.72.0-0.5
Delta time in open arm before/after self-admin3.23.17.20.7-2.01.1-0.3-1.62.7-2.71.4
Diff in mean of infusions in LGA sessions2.12.34.9-2.11.2-1.8-2.2-2.00.1-0.80.4
Delay discount exponential model param0.30.30.80.9-0.30.50.40.40.30.10.8
Extinction: sum of active levers before priming0.90.92.5-0.70.4-0.7-1.3-1.61.1-0.7-0.2
Active lever presses in extinction session 60.10.10.10.3-0.30.30.30.40.10.00.1
Bone: final force0.71.22.61.6-1.41.50.90.51.3-0.20.4
Bone: final moment0.50.81.81.3-1.11.20.70.41.2-0.30.3
Food consumed during 24 hour testing period1.31.64.00.8-0.91.0-0.4-1.32.0-1.90.6
Glucose0.60.91.7-0.91.0-1.1-0.20.3-1.11.3-1.0
Heart weight0.40.63.60.3-0.70.60.40.50.3-0.11.9
Delay discount hyperbolic model param0.40.40.91.0-0.50.70.50.40.40.20.9
Intermittent access intake day 1-15 change0.40.40.9-0.8-0.1-0.6-0.6-0.90.4-0.70.8
Intermittent access intake escalation0.90.91.9-0.8-0.2-0.5-0.8-1.40.8-1.11.3
Intermittent access intake escalation 21.11.12.5-0.8-0.1-0.4-1.1-1.61.1-1.31.1
Intermitt. access day 1 inactive lever presses0.60.61.20.9-0.51.11.00.9-0.20.10.9
Intermitt. access day 15 inactive lever presses1.31.43.10.9-1.41.1-0.1-0.91.8-1.11.4
Intermitt. access escalation Index1.41.22.9-1.01.1-0.6-1.7-1.60.8-0.80.7
Intermittent access day 1 total infusions0.10.10.40.6-0.10.20.30.5-0.1-0.0-0.2
Intermittent access day 15 total infusions0.20.30.6-0.60.5-0.8-0.6-0.50.1-0.40.3
Intermittent access terminal intake (last 3 days)0.70.81.4-0.90.7-1.0-1.1-1.20.4-1.00.7
Intermittent access total infusions0.10.10.40.10.2-0.3-0.3-0.20.3-0.60.1
Intermittent access day 1 locomotion0.10.10.60.2-0.10.10.20.8-0.1-0.2-0.3
Intermittent access day 15 total locomotion0.40.40.8-0.60.7-0.4-0.9-0.60.6-0.9-0.2
Intermittent access total locomotion0.50.61.3-1.20.7-1.1-1.0-0.4-0.2-0.8-0.5
Intermittent access standard deviation1.51.63.6-0.1-1.10.5-0.6-1.21.9-1.81.5
Left kidney weight0.10.41.90.10.2-0.20.60.3-0.61.4-0.5
Right kidney weight0.61.86.30.9-0.20.31.71.6-1.22.5-0.6
Cocaine induced anxiety0.40.51.40.2-0.10.2-0.7-1.11.2-0.80.3
Post-drug Anxiety0.50.61.0-0.70.9-1.0-0.9-1.00.1-0.0-0.6
Baseline Anxiety0.60.62.1-0.50.5-0.70.50.7-1.41.0-0.2
Tail length4.112.426.24.8-3.94.15.13.50.32.00.6
Length with tail3.914.428.25.2-4.74.45.33.21.42.20.9
Length without tail0.92.04.01.5-1.61.12.01.50.41.80.3
Times rat made contact with spout1.11.32.11.2-1.21.50.4-0.21.3-1.41.2
Lifetime Intake0.10.10.4-0.10.6-0.6-0.3-0.1-0.1-0.3-0.3
Liver weight, left1.11.83.61.8-1.61.91.20.51.2-0.31.3
Liver weight, right0.71.22.61.2-1.31.50.70.31.1-0.41.6
Locomotor activity0.10.20.6-0.50.6-0.5-0.2-0.0-0.30.10.8
Locomotor testing distance0.10.10.8-0.20.2-0.2-0.00.1-0.3-0.30.9
Locomotor testing rearing0.00.10.50.0-0.1-0.00.10.10.10.00.7
Locomotion in novel chamber1.01.23.0-1.40.7-1.2-1.7-1.50.3-0.5-0.2
Locomotion in novel chamber post-restriction0.40.51.3-0.60.2-0.70.40.9-1.11.0-0.4
Fecal boli incidents, locomotor time 10.90.92.31.5-1.40.90.90.31.10.10.7
Change in fecal boli incidents, locomotor task0.10.10.4-0.4-0.20.2-0.2-0.10.2-0.70.6
Time >=10cm from walls, locomotor time 11.61.63.01.2-1.51.61.21.10.7-0.81.7
Bouts of movement, locomotor time 11.21.33.80.9-1.01.01.51.2-0.40.11.9
Total resting periods, locomotor time 11.31.43.50.9-0.81.11.61.4-0.80.21.9
Rest time, locomotor task time 10.90.93.30.7-0.81.01.20.8-0.10.21.8
Distance moved, locomotor task time 10.91.05.2-0.20.6-0.50.00.7-0.91.0-2.3
Vertical activity count, locomotor time 10.50.51.8-0.40.9-0.6-0.9-0.30.00.1-1.3
Time >=10cm from walls, locomotor time 20.60.72.00.5-0.90.90.3-0.30.7-1.40.9
Bouts of movement, locomotor time 20.60.72.0-1.00.5-0.9-0.00.7-1.41.0-0.1
Total resting periods, locomotor time 20.40.41.2-0.60.1-0.40.30.8-1.10.80.4
Rest time, locomotor task time 21.72.04.61.1-1.01.22.11.6-0.70.82.1
Distance moved, locomotor task time 20.70.84.2-0.70.7-0.6-0.5-0.0-0.80.3-2.0
Vertical activity count, locomotor time 22.22.44.4-1.71.9-1.6-2.1-1.7-0.3-0.4-1.7
Light reinforcement 10.91.62.7-1.61.6-1.5-1.5-1.5-0.7-0.3-0.8
Light reinforcement 20.50.72.20.7-0.70.8-0.1-0.91.5-0.90.3
Bone: marrow area0.91.93.61.9-1.81.71.40.41.3-0.11.1
Bone: maximum diameter0.91.73.21.4-1.51.31.81.40.10.81.3
Bone: maximum force0.40.71.41.1-0.91.00.4-0.21.2-0.80.1
Bone: maximum moment0.30.41.10.8-0.60.70.1-0.31.1-0.9-0.0
Mean time between licks in bursts0.20.30.7-0.80.7-0.8-0.3-0.1-0.50.80.1
Mean num. licks in bursts0.91.02.70.8-1.01.20.2-0.31.1-1.61.2
Cd content in liver0.90.92.9-0.40.2-0.2-1.0-1.71.2-1.30.4
Co content in liver0.20.20.5-0.40.3-0.4-0.6-0.50.3-0.2-0.7
Cu content in liver1.01.24.20.2-0.1-0.21.01.6-1.02.0-0.9
Fe content in liver0.40.50.91.0-0.60.90.30.00.8-0.10.9
K content in liver0.60.60.9-0.70.9-0.9-0.30.3-1.00.9-0.9
Mg content in liver0.60.61.1-0.91.0-1.0-0.9-0.3-0.40.5-0.8
Mn content in liver1.31.53.3-1.81.6-1.7-1.2-0.8-1.10.4-0.1
Na content in liver0.20.20.60.8-0.50.60.30.40.50.4-0.0
Rb content in liver0.20.20.8-0.40.1-0.3-0.10.9-0.40.7-0.2
Se content in liver0.20.30.8-0.50.6-0.6-0.2-0.2-0.40.9-0.2
Sr content in liver1.21.12.90.3-0.50.51.21.3-1.20.91.7
Zn content in liver0.50.61.7-0.60.7-0.8-0.20.1-0.60.8-1.3
Bone: minimum diameter1.22.24.12.0-1.71.71.91.60.50.80.8
Time in familiar zone, hab. session 13.33.06.3-1.91.6-1.7-2.5-2.40.8-1.6-0.7
Time in novel zone, hab. session 15.14.98.12.8-2.82.82.61.90.70.42.2
Total zone transitions, hab. session 11.01.43.61.0-0.70.71.61.9-1.01.3-0.3
Total locomotion distance, hab. session 11.01.42.41.3-1.31.31.51.5-0.00.51.0
Locomotion velocity, hab. session 11.11.63.51.3-1.11.11.81.9-0.51.20.6
Time in familiar zone, hab. session 20.90.92.4-0.30.7-0.2-1.1-1.50.8-1.4-0.6
Time in novel zone, hab. session 20.70.71.60.2-0.50.11.01.2-0.81.30.9
Total zone transitions, hab. session 20.00.00.00.00.00.20.1-0.1-0.1-0.10.1
Total locomotion distance, hab. session 20.00.10.2-0.00.00.10.30.2-0.40.20.4
Locomotion velocity, hab. session 20.10.10.2-0.00.00.00.40.3-0.40.30.3
Novel to familiar place preference ratio1.11.13.11.2-1.20.91.81.1-0.30.90.1
Novelty place preference1.01.02.81.2-1.30.91.70.9-0.10.80.3
Time in novel zone, NPP test1.11.12.81.4-1.41.11.70.80.10.70.4
Total zone transitions, NPP test0.00.10.20.10.00.20.30.2-0.4-0.00.0
Total locomotion distance, NPP test0.20.30.70.3-0.40.40.90.8-0.70.10.5
Locomotion velocity, NPP test0.20.31.0-0.1-0.10.10.60.7-1.00.10.3
Intraocular pressure0.81.12.1-1.51.1-1.1-1.4-1.1-0.5-0.8-0.8
Delta distance traveled before/after self-admin1.01.03.2-1.01.8-1.1-0.9-0.0-0.70.7-1.0
Delta ambulatory time before/after self-admin0.70.72.1-0.51.4-0.6-0.40.5-0.71.0-1.1
Parametrial fat weight1.63.26.81.9-1.01.52.62.2-1.12.2-0.9
Pavlov. Cond. lever latency1.72.16.3-0.20.00.2-1.3-2.31.5-2.51.2
Pavlov. Cond. magazine entry latency0.50.61.21.0-0.80.81.01.10.30.6-0.5
Pavlov. Cond. change in total contacts1.21.33.0-0.00.3-0.50.71.6-1.31.6-1.7
Pavlov. Cond. index score0.81.13.00.8-0.60.51.21.7-0.41.5-0.7
Pavlov. Cond. latency score0.81.02.70.8-0.50.51.11.7-0.41.4-0.7
Pavlov. Cond. lever contacts0.80.92.60.0-0.1-0.10.81.6-1.01.6-0.5
Pavlov. Cond. magazine entry number0.81.12.9-0.90.7-0.8-1.4-1.70.6-1.00.5
Pavlov. Cond. intertrial magazine entries0.30.31.8-0.30.2-0.20.10.3-0.40.41.3
Pavlov. Cond. lever-magazine prob. diff.0.60.72.20.6-0.60.41.01.5-0.31.1-0.6
Pavlov. Cond. response bias1.01.23.80.8-0.80.71.51.9-0.71.3-0.1
Pavlov. Cond. lever latency1.21.63.6-0.91.3-1.20.10.3-1.91.5-1.6
Pavlov. Cond. magazine entry latency1.21.44.90.2-0.60.6-0.7-1.21.7-2.21.1
Pavlov. Cond. change in total contacts0.91.22.20.9-1.41.20.40.31.3-1.11.5
Pavlov. Cond. index score1.82.34.60.9-1.51.4-0.1-0.52.1-2.02.1
Pavlov. Cond. latency score1.62.04.20.9-1.51.3-0.1-0.52.1-1.91.8
Pavlov. Cond. lever contacts1.72.34.11.4-1.81.70.4-0.02.0-1.42.0
Pavlov. Cond. magazine entry number1.51.84.7-0.50.9-0.90.61.0-1.92.2-1.7
Pavlov. Cond. intertrial magazine entries2.83.610.4-0.61.4-1.30.71.5-2.63.2-2.3
Pavlov. Cond. lever-magazine prob. diff.1.92.55.20.8-1.41.3-0.3-0.72.2-2.32.2
Pavlov. Cond. response bias1.92.54.91.2-1.71.60.1-0.32.2-1.92.2
Time in closed arm before self-admin1.41.63.81.7-0.81.90.40.01.9-1.00.9
Time in closed arm after self-admin1.21.23.01.1-0.30.91.31.7-0.61.5-0.2
Time in open arm before self-admin3.03.38.1-2.12.0-2.3-0.40.6-2.81.8-0.7
Time in open arm after self-admin0.70.72.10.0-0.90.2-0.2-1.00.9-1.41.1
Bone: periosteal estimation1.22.54.52.1-1.91.82.11.60.40.70.9
Bone: periosteal perimeter0.91.52.61.5-1.61.51.20.51.0-0.31.5
Bone: post-yield work0.60.82.7-0.00.10.1-0.7-1.41.0-1.6-0.3
Progressive ratio test 1 active lever presses0.10.10.5-0.40.5-0.7-0.20.2-0.20.2-0.1
Progressive ratio test 1 breakpoint0.10.10.4-0.30.4-0.6-0.20.10.00.10.0
Progressive ratio test 1 inactive lever presses0.30.30.7-0.80.7-0.8-0.6-0.6-0.2-0.20.3
Progressive ratio test 2 active lever presses0.10.10.2-0.10.3-0.40.10.3-0.30.10.3
Progressive ratio test 2 breakpoint0.10.10.3-0.10.1-0.20.10.3-0.10.10.5
Progressive ratio test 2 inactive lever presses0.10.10.30.10.0-0.0-0.2-0.10.2-0.60.5
Incentive Sensitization - Responses0.10.10.30.0-0.10.20.20.30.1-0.10.5
Incentive Sensitization - Breakpoint0.10.10.30.1-0.00.30.30.30.1-0.10.6
Sum of active levers in priming session hrs 5-60.40.41.20.4-0.40.10.40.7-0.11.1-1.0
Progressive ratio0.50.51.70.3-0.30.30.81.3-0.81.00.2
Food seeking constrained by brief footshock2.12.65.0-2.02.0-2.2-1.6-1.1-0.90.7-1.6
Seeking ratio, punishment vs. effort1.31.63.1-1.21.3-1.4-1.7-1.80.5-0.6-1.2
Retroperitoneal fat weight0.51.86.4-0.71.6-1.3-0.50.0-0.91.5-2.5
Reaction time number correct0.50.71.6-1.30.7-1.0-1.3-0.8-0.2-0.40.5
Reaction time mean minus median0.10.10.40.5-0.30.60.2-0.30.1-0.40.3
Reaction time mean minus median AUC0.30.30.50.5-0.60.70.0-0.50.7-0.70.7
Reaction time num false alarms1.92.64.9-1.92.2-2.2-1.2-0.5-1.61.1-1.6
Reaction time num false alarms AUC1.62.23.7-1.61.9-1.9-0.7-0.2-1.81.3-1.3
Reaction time trials correct on left0.50.71.6-1.30.7-1.0-1.3-0.8-0.2-0.40.5
Reaction time trials on left0.50.71.5-1.20.7-1.0-1.2-0.8-0.2-0.30.5
Reaction time mean2.63.77.02.4-2.62.61.81.11.5-0.51.6
Reaction time mean AUC2.33.16.02.3-2.42.41.91.31.1-0.11.2
Median of all reaction times3.64.99.62.8-3.12.92.31.71.5-0.11.7
Reaction time omissions0.40.61.60.9-0.10.70.90.7-0.41.3-0.5
Reaction time false alarm rate0.91.32.5-0.71.3-1.10.10.3-1.51.4-1.6
Reaction time premature initiation rate0.40.61.40.3-1.00.5-0.3-0.31.1-0.71.2
Reaction time premature initiations0.60.81.8-0.5-0.5-0.1-1.1-0.91.0-1.11.4
Std. dev. reaction times0.91.33.01.6-1.31.71.00.11.0-0.50.7
Reaction time trials completed0.50.71.5-1.20.7-1.0-1.2-0.8-0.2-0.30.5
Reaction time trials AUC0.40.51.2-1.10.5-0.9-1.1-0.7-0.1-0.30.6
Run reversals in cocaine runway, females0.60.62.3-0.30.3-0.40.50.8-1.50.6-1.0
Run reversals in cocaine runway, males0.10.10.20.2-0.40.10.30.20.10.2-0.3
Latency to leave start box in cocaine runway1.92.15.0-1.61.3-1.8-0.20.9-2.21.6-0.9
Latency to leave start box in cocaine runway, F1.61.73.5-1.51.5-1.7-0.40.5-1.91.4-1.0
Latency to leave start box in cocaine runway, M0.10.10.2-0.2-0.3-0.10.10.4-0.20.00.5
Std. dev. time between licks in bursts2.22.64.7-2.02.1-2.1-1.0-0.1-2.21.2-1.0
Total sessions with >9 infusions0.20.20.80.2-0.0-0.10.60.9-0.50.20.5
Short access day 1 total inactive lever presses0.20.30.6-0.30.5-0.3-0.6-0.50.5-0.8-0.5
Short access day 10 total inactive lever presses1.21.32.81.1-1.31.70.5-0.21.5-0.91.2
Short access day 1 total infusions0.70.81.5-0.91.0-1.2-1.2-0.90.2-0.5-0.4
Short access day 10 total infusions0.10.10.30.4-0.0-0.00.1-0.10.6-0.60.5
Short access total infusions0.40.51.1-0.71.0-1.1-0.6-0.3-0.6-0.2-0.4
Short access day 1 locomotion0.80.82.20.6-0.70.61.31.5-0.31.00.7
Short access day 10 total locomotion0.70.72.00.4-0.60.8-0.1-0.31.3-1.41.1
Short access total locomotion0.10.10.2-0.20.3-0.1-0.10.2-0.0-0.50.1
One hour access (0.3 mA shock)0.40.41.30.4-0.70.5-0.2-0.10.9-1.20.5
Compulsive drug intake0.30.30.60.7-0.60.70.60.8-0.20.10.2
One hour access (shock baseline)0.10.20.60.4-0.1-0.0-0.2-0.40.8-0.60.3
Social response proportion0.20.21.10.10.0-0.10.40.3-0.41.0-0.3
Social responses0.20.30.50.5-0.60.60.70.50.10.70.2
Social time0.40.51.30.2-1.00.3-0.2-0.41.0-0.41.1
Soleus weight0.00.10.7-0.10.4-0.10.3-0.2-0.90.10.0
Bone: stiffness0.40.61.61.0-0.60.90.2-0.61.3-0.70.1
Tibialis anterior weight0.31.22.1-1.31.4-1.3-0.8-0.5-0.90.5-1.4
Time to tail flick, vehicle, before self-admin0.10.10.20.20.00.30.40.5-0.30.10.3
Time to tail flick, vehicle, after self-admin0.50.51.11.0-0.61.10.80.40.1-0.30.8
Time to tail flick, test, before self-admin1.01.01.81.3-0.71.11.21.3-0.40.9-0.7
Time to tail flick, test, after self-admin3.13.26.3-2.51.9-2.3-2.3-1.9-0.4-0.9-0.9
Delta time to tail flick, vehicle, before/after SA0.60.61.7-0.30.2-0.2-1.0-1.30.8-1.1-0.3
Delta time to tail flick, test, before/after SA4.54.07.9-2.81.8-2.4-2.7-2.30.2-1.40.3
Tibia length1.33.77.62.6-2.22.22.82.00.31.10.4
Ambulatory time before self-admin0.30.31.30.2-0.20.1-0.5-0.81.2-0.5-0.3
Ambulatory time after self-admin1.31.43.6-0.81.9-1.1-1.20.0-0.41.0-1.9
Bone: tissue strength0.30.31.9-0.20.5-0.5-0.2-0.2-0.20.2-1.4
Total heroin consumption0.81.03.00.9-1.70.90.1-0.71.3-0.80.6
Bone: trabecular number0.20.30.9-0.30.8-0.3-0.8-0.50.30.3-0.9
Bone: trabecular spacing0.70.92.30.8-1.10.71.31.5-0.50.40.2
Bone: trabecular thickness0.60.71.60.7-0.40.7-0.2-1.01.3-1.1-0.1
Bone: trabecular tissue density0.70.92.90.5-1.01.00.70.60.2-1.31.7
Water consumed over 24 hours0.10.20.4-0.40.3-0.1-0.6-0.50.1-0.60.3
Number of responses in last shaping day2.22.35.41.3-1.00.81.92.3-0.82.3-0.2