Ugt2b7l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ugt2b7l1 0.13 0.1 6.0e-08 0.04 0.04 0.04 0 1.7e-05 5.2e-05 1.2e-05 3.5e-01
2 Liver gene expression Ugt2b7l1 0.15 0.08 4.8e-12 0.07 0.07 0.05 0.07 8.6e-08 7.9e-08 1.2e-06 6.5e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.00.0-0.20.2
Area under the delay curve0.40.70.80.70.9
BMI with tail1.03.76.9-0.62.6
BMI without tail0.63.16.1-0.32.5
Body weight0.52.14.10.32.0
Weight adjusted by age0.41.32.1-1.4-0.8
Bone surface0.40.80.9-0.8-1.0
Bone volume0.10.10.10.4-0.3
Breakpoint value in progressive ratio session0.10.10.20.40.2
Number of licking bursts0.00.10.2-0.4-0.1
Context. condit. distance diff. score3.54.26.8-1.3-2.6
Locomotion velocity, session 11.41.63.20.21.8
Locomotion distance, session 10.10.10.10.2-0.3
Locomotion velocity, session 20.10.10.2-0.2-0.5
Locomotion distance, session 20.00.00.10.3-0.1
Locomotion velocity, session 30.30.30.50.7-0.3
Locomotion distance, session 30.00.10.10.1-0.3
Stereotopy head waving bouts, day 30.40.50.9-0.20.9
Stereotopy head waving duration, day 30.10.20.30.10.6
Locomotion velocity, session 71.61.83.31.80.5
Locomotion distance, session 70.50.61.01.0-0.4
Stereotopy head waving bouts, day 70.10.20.3-0.60.1
Stereotopy head waving duration, day 70.50.61.20.11.1
Locomotion velocity, session 80.70.81.1-0.7-1.1
Locomotion distance, session 82.33.36.1-0.7-2.5
Degree of sensitization distance0.30.30.50.7-0.4
Degree of sensitization stereotypy0.10.10.1-0.3-0.3
Conditioned locomotion0.40.50.7-0.8-0.5
Cocaine response after cond. corrected0.20.30.60.8-0.2
Cocaine response after cond. not corrected0.20.30.50.4-0.7
Cocaine response before conditioning0.50.60.8-0.9-0.7
Saline control response0.10.20.20.5-0.4
Bone: connectivity density0.10.20.2-0.30.5
Bone: cortical apparent density3.04.76.41.72.5
Bone: cortical area0.20.30.40.70.4
Bone: cortical porosity1.51.72.6-1.6-0.8
Bone: cortical porosity1.82.03.9-2.0-0.3
Bone: cortical thickness0.10.20.2-0.50.5
Bone: cortical thickness0.70.91.6-0.4-1.3
Bone: cortical tissue density2.94.66.41.72.5
Condit. Reinf. active minus inactive responses0.40.40.7-0.50.8
Condit. Reinf. active-inactive response ratio1.61.83.5-1.90.1
Condit. Reinf. active responses0.20.20.20.40.5
Condit. Reinf. inactive responses1.01.32.71.6-0.0
Incentive salience index mean0.10.20.3-0.00.6
Condit. Reinf. lever presses0.00.00.0-0.2-0.2
Condit. Reinf. active minus inactive responses0.10.10.20.50.3
Condit. Reinf. active-inactive response ratio0.20.30.40.60.4
Condit. Reinf. active responses0.00.00.10.2-0.2
Condit. Reinf. inactive responses0.30.40.8-0.1-0.9
Condit. Reinf. lever presses0.60.81.60.1-1.3
Condit. Reinf. lever reinforcers received0.10.20.40.1-0.6
Conditioned reinforcement - actives0.10.60.6-0.8-0.7
Conditioned reinforcement - inactives0.10.30.70.8-0.1
Conditioned locomotion0.00.00.0-0.2-0.2
Patch foraging indifference point 0 sec0.10.30.60.80.0
Patch foraging indifference point AUC1.63.87.12.70.6
Delay disc. indifference point, 0s delay0.40.40.70.40.8
Delay disc. indifference point, 16s delay0.91.32.40.41.6
Delay disc. indifference point, 2s delay1.41.63.21.80.1
Delay disc. indifference point, 24s delay0.00.00.0-0.1-0.0
Delay disc. indifference point, 4s delay1.61.61.71.31.3
Delay disc. indifference point, 8s delay0.30.51.0-0.41.0
Indifference point function ln k0.72.03.5-1.9-0.7
Indifference point function log k0.72.03.5-1.9-0.7
Patch foraging total patch changes 0 sec0.10.40.80.90.1
Patch foraging total patch changes 12 sec1.52.03.11.70.9
Patch foraging total patch changes 18 sec0.30.71.11.10.5
Patch foraging total patch changes 24 sec0.20.81.61.3-0.2
Patch foraging total patch changes 6 sec1.32.24.22.10.4
Patch foraging time to switch 0 sec0.62.33.8-1.90.9
Patch foraging water rate 0 sec0.41.32.61.6-0.1
Patch foraging water rate 12 sec0.21.01.9-0.2-1.4
Patch foraging water rate 18 sec0.51.11.80.6-1.3
Patch foraging water rate 24 sec1.62.34.7-0.0-2.2
Patch foraging water rate 6 sec0.20.30.60.8-0.0
Seeking ratio, delayed vs. immediate footshock0.20.30.30.4-0.6
Distance traveled before self-admin0.10.10.2-0.3-0.4
Distance traveled after self-admin1.62.85.20.6-2.3
Extensor digitorum longus weight4.016.131.9-5.70.5
Bone: elastic displacement1.62.02.5-1.3-1.6
Bone: elastic work2.12.73.5-1.4-1.9
Bone: endosteal estimation0.40.91.00.9-1.0
Bone: endosteal perimeter0.10.30.60.1-0.8
Epididymis fat weight1.15.78.21.82.9
Delta time in closed arm before/after self-admin0.30.30.3-0.60.4
Delta time in open arm before/after self-admin0.70.81.11.00.8
Diff in mean of infusions in LGA sessions0.20.40.5-0.4-0.7
Delay discount exponential model param0.50.70.7-0.8-0.8
Extinction: sum of active levers before priming0.71.11.5-0.8-1.2
Active lever presses in extinction session 60.30.30.60.80.1
Bone: final force0.00.10.10.10.3
Bone: final moment0.00.00.00.10.2
Food consumed during 24 hour testing period0.81.73.10.5-1.8
Glucose0.30.40.70.8-0.4
Heart weight0.20.30.5-0.70.4
Delay discount hyperbolic model param0.50.70.9-1.0-0.7
Intermittent access intake day 1-15 change0.10.40.8-0.9-0.3
Intermittent access intake escalation0.10.40.8-0.9-0.0
Intermittent access intake escalation 20.10.10.20.40.1
Intermitt. access day 1 inactive lever presses0.11.42.01.4-0.9
Intermitt. access day 15 inactive lever presses0.42.14.12.0-0.3
Intermitt. access escalation Index0.10.30.7-0.8-0.0
Intermittent access day 1 total infusions0.10.30.5-0.4-0.7
Intermittent access day 15 total infusions0.30.70.9-0.7-0.9
Intermittent access terminal intake (last 3 days)0.30.40.9-0.0-0.9
Intermittent access total infusions0.30.40.6-0.5-0.7
Intermittent access day 1 locomotion0.00.10.10.2-0.3
Intermittent access day 15 total locomotion0.00.00.0-0.10.2
Intermittent access total locomotion0.10.10.2-0.10.5
Intermittent access standard deviation0.10.50.60.6-0.8
Left kidney weight0.00.00.0-0.10.0
Right kidney weight0.31.82.11.31.4
Cocaine induced anxiety0.10.30.60.00.8
Post-drug Anxiety0.30.40.60.40.8
Baseline Anxiety1.22.13.7-0.6-1.9
Tail length0.10.50.60.8-0.6
Length with tail0.10.40.70.4-0.8
Length without tail0.10.40.80.1-0.9
Times rat made contact with spout0.30.40.40.60.6
Lifetime Intake0.30.30.4-0.6-0.5
Liver weight, left1.62.83.51.91.4
Liver weight, right0.71.32.51.60.3
Locomotor activity0.91.42.4-0.7-1.5
Locomotor testing distance1.43.44.8-1.4-2.2
Locomotor testing rearing0.83.04.3-1.4-2.1
Locomotion in novel chamber0.00.00.0-0.0-0.1
Locomotion in novel chamber post-restriction0.61.72.11.41.1
Fecal boli incidents, locomotor time 10.41.22.1-1.4-0.5
Change in fecal boli incidents, locomotor task0.00.00.0-0.1-0.0
Time >=10cm from walls, locomotor time 10.50.61.2-1.1-0.2
Bouts of movement, locomotor time 10.30.30.5-0.40.7
Total resting periods, locomotor time 10.30.30.5-0.20.7
Rest time, locomotor task time 11.01.63.0-0.4-1.7
Distance moved, locomotor task time 10.00.10.2-0.10.4
Vertical activity count, locomotor time 10.43.14.01.52.0
Time >=10cm from walls, locomotor time 20.41.21.2-1.1-1.1
Bouts of movement, locomotor time 20.00.10.20.4-0.0
Total resting periods, locomotor time 20.00.10.20.40.2
Rest time, locomotor task time 21.32.13.9-0.6-2.0
Distance moved, locomotor task time 20.50.60.9-0.60.9
Vertical activity count, locomotor time 20.92.02.81.11.7
Light reinforcement 10.10.51.01.00.0
Light reinforcement 20.00.10.1-0.00.3
Bone: marrow area0.40.91.20.8-1.1
Bone: maximum diameter0.30.61.00.51.0
Bone: maximum force0.00.00.10.0-0.3
Bone: maximum moment0.00.10.10.1-0.3
Mean time between licks in bursts0.42.33.7-1.91.0
Mean num. licks in bursts0.30.91.41.20.6
Cd content in liver1.82.03.9-2.00.2
Co content in liver0.00.00.1-0.30.0
Cu content in liver0.00.00.10.30.1
Fe content in liver0.70.91.70.21.3
K content in liver1.31.31.61.31.0
Mg content in liver1.21.31.41.11.2
Mn content in liver0.20.20.3-0.5-0.3
Na content in liver1.41.62.31.50.9
Rb content in liver0.50.50.7-0.60.9
Se content in liver0.30.40.50.70.6
Sr content in liver2.32.02.2-1.3-1.5
Zn content in liver0.00.00.1-0.20.1
Bone: minimum diameter1.52.95.62.4-0.4
Time in familiar zone, hab. session 10.70.71.3-0.4-1.2
Time in novel zone, hab. session 12.12.34.30.62.1
Total zone transitions, hab. session 10.10.20.30.60.0
Total locomotion distance, hab. session 10.91.32.00.8-1.4
Locomotion velocity, hab. session 11.11.52.80.5-1.7
Time in familiar zone, hab. session 20.10.10.1-0.2-0.3
Time in novel zone, hab. session 21.51.62.70.71.6
Total zone transitions, hab. session 20.30.40.6-0.4-0.8
Total locomotion distance, hab. session 20.50.71.40.1-1.2
Locomotion velocity, hab. session 20.70.91.8-0.0-1.3
Novel to familiar place preference ratio1.62.12.81.21.7
Novelty place preference2.12.74.01.12.0
Time in novel zone, NPP test2.83.44.71.42.2
Total zone transitions, NPP test0.10.10.10.30.3
Total locomotion distance, NPP test0.50.71.3-0.2-1.2
Locomotion velocity, NPP test0.60.81.4-0.5-1.2
Intraocular pressure0.30.50.8-0.50.9
Delta distance traveled before/after self-admin1.31.42.20.8-1.5
Delta ambulatory time before/after self-admin0.50.91.50.4-1.2
Parametrial fat weight2.04.77.82.81.3
Pavlov. Cond. lever latency0.91.11.8-1.3-0.7
Pavlov. Cond. magazine entry latency0.20.30.4-0.5-0.6
Pavlov. Cond. change in total contacts0.20.20.30.30.5
Pavlov. Cond. index score0.20.30.40.60.4
Pavlov. Cond. latency score0.20.30.40.70.3
Pavlov. Cond. lever contacts0.50.61.01.00.5
Pavlov. Cond. magazine entry number0.00.00.00.10.0
Pavlov. Cond. intertrial magazine entries1.41.71.71.31.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.70.3
Pavlov. Cond. response bias0.20.20.40.60.2
Pavlov. Cond. lever latency1.62.22.31.51.5
Pavlov. Cond. magazine entry latency1.72.43.5-1.9-1.1
Pavlov. Cond. change in total contacts1.02.52.9-1.7-1.5
Pavlov. Cond. index score2.23.53.9-2.0-1.7
Pavlov. Cond. latency score2.74.45.3-2.3-1.8
Pavlov. Cond. lever contacts1.01.51.8-1.0-1.4
Pavlov. Cond. magazine entry number3.24.26.42.51.4
Pavlov. Cond. intertrial magazine entries1.43.05.02.21.0
Pavlov. Cond. lever-magazine prob. diff.2.13.23.7-1.9-1.6
Pavlov. Cond. response bias1.62.22.5-1.6-1.4
Time in closed arm before self-admin0.20.30.50.70.2
Time in closed arm after self-admin0.20.20.3-0.5-0.4
Time in open arm before self-admin2.93.53.7-1.8-1.9
Time in open arm after self-admin1.11.22.01.40.6
Bone: periosteal estimation0.10.40.60.8-0.3
Bone: periosteal perimeter0.10.10.20.2-0.5
Bone: post-yield work0.10.20.30.40.5
Progressive ratio test 1 active lever presses0.30.50.7-0.8-0.6
Progressive ratio test 1 breakpoint0.40.60.7-0.8-0.8
Progressive ratio test 1 inactive lever presses0.51.21.81.3-0.8
Progressive ratio test 2 active lever presses0.10.10.2-0.5-0.1
Progressive ratio test 2 breakpoint0.10.20.3-0.5-0.2
Progressive ratio test 2 inactive lever presses0.10.40.50.7-0.5
Incentive Sensitization - Responses0.10.10.2-0.40.3
Incentive Sensitization - Breakpoint0.10.20.3-0.50.1
Sum of active levers in priming session hrs 5-60.40.40.8-0.3-0.9
Progressive ratio0.10.30.4-0.5-0.6
Food seeking constrained by brief footshock0.00.00.1-0.30.0
Seeking ratio, punishment vs. effort0.61.21.61.30.9
Retroperitoneal fat weight0.94.04.22.02.1
Reaction time number correct0.00.20.3-0.5-0.2
Reaction time mean minus median0.21.12.20.21.5
Reaction time mean minus median AUC0.53.25.70.82.4
Reaction time num false alarms1.11.92.01.31.4
Reaction time num false alarms AUC0.71.62.11.11.4
Reaction time trials correct on left0.00.20.3-0.5-0.2
Reaction time trials on left0.10.20.4-0.6-0.2
Reaction time mean0.30.81.5-0.01.2
Reaction time mean AUC0.41.01.90.21.4
Median of all reaction times0.30.50.9-0.11.0
Reaction time omissions0.30.50.8-0.90.3
Reaction time false alarm rate1.21.72.01.21.4
Reaction time premature initiation rate0.40.70.90.90.7
Reaction time premature initiations0.20.60.70.80.8
Std. dev. reaction times0.20.81.60.11.3
Reaction time trials completed0.10.20.4-0.6-0.2
Reaction time trials AUC0.00.10.3-0.5-0.0
Run reversals in cocaine runway, females0.70.81.31.1-0.5
Run reversals in cocaine runway, males0.10.10.2-0.4-0.3
Latency to leave start box in cocaine runway1.11.63.01.70.3
Latency to leave start box in cocaine runway, F2.53.15.92.40.5
Latency to leave start box in cocaine runway, M0.00.00.10.0-0.3
Std. dev. time between licks in bursts0.91.73.2-1.8-0.5
Total sessions with >9 infusions0.60.81.5-1.20.4
Short access day 1 total inactive lever presses0.40.81.50.3-1.2
Short access day 10 total inactive lever presses0.21.01.30.9-1.1
Short access day 1 total infusions0.00.10.10.3-0.0
Short access day 10 total infusions0.50.81.2-1.1-0.7
Short access total infusions0.30.40.8-0.9-0.2
Short access day 1 locomotion0.40.70.7-0.9-0.8
Short access day 10 total locomotion0.00.00.1-0.10.3
Short access total locomotion0.10.20.3-0.60.1
One hour access (0.3 mA shock)0.20.20.40.0-0.6
Compulsive drug intake0.20.30.60.8-0.2
One hour access (shock baseline)0.00.00.0-0.20.2
Social response proportion1.82.23.61.90.9
Social responses0.60.81.21.10.5
Social time0.40.61.11.00.4
Soleus weight1.33.94.0-2.0-2.0
Bone: stiffness1.11.92.21.51.3
Tibialis anterior weight1.45.08.2-2.91.3
Time to tail flick, vehicle, before self-admin0.40.50.80.9-0.4
Time to tail flick, vehicle, after self-admin1.22.54.8-0.4-2.2
Time to tail flick, test, before self-admin0.30.30.4-0.4-0.6
Time to tail flick, test, after self-admin0.80.81.71.3-0.0
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.1-0.4
Delta time to tail flick, test, before/after SA1.51.82.71.70.9
Tibia length0.20.60.60.70.7
Ambulatory time before self-admin0.00.10.1-0.2-0.4
Ambulatory time after self-admin1.22.03.40.7-1.8
Bone: tissue strength0.30.30.50.7-0.2
Total heroin consumption0.60.61.3-0.2-1.1
Bone: trabecular number0.30.60.90.50.9
Bone: trabecular spacing1.11.62.50.81.6
Bone: trabecular thickness0.30.40.90.0-0.9
Bone: trabecular tissue density0.40.71.4-0.21.2
Water consumed over 24 hours0.30.60.90.9-0.5
Number of responses in last shaping day0.20.20.4-0.20.6