Hub : Genes

Ugt2b7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Ugt2b7	0.04	0.03	8.8e-04	0.01	0.01	0.01	-0	1.6e-02	1.3e-02	5.3e-02	6.4e-01
2	Liver	gene expression	Ugt2b7	0.18	0.11	3.1e-14	0.08	0.09	0.08	0.1	5.3e-09	4.9e-10	1.6e-09	1.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.0	0.0	0.1	0.1
Area under the delay curve	0.3	0.5	0.6	-0.6	0.8
BMI with tail	0.4	1.6	2.8	0.6	1.7
BMI without tail	0.3	1.5	2.8	0.4	1.7
Body weight	0.4	1.6	3.0	-0.5	1.7
Weight adjusted by age	0.9	2.5	2.6	1.6	-1.6
Bone surface	0.3	0.6	0.8	0.7	-0.9
Bone volume	0.0	0.1	0.2	-0.4	-0.0
Breakpoint value in progressive ratio session	0.2	0.4	0.5	-0.6	0.7
Number of licking bursts	0.0	0.1	0.2	0.4	-0.3
Context. condit. distance diff. score	3.0	3.6	5.3	1.4	-2.3
Locomotion velocity, session 1	0.9	1.0	1.9	-0.3	1.4
Locomotion distance, session 1	0.0	0.0	0.1	-0.3	0.1
Locomotion velocity, session 2	0.1	0.1	0.1	0.2	-0.4
Locomotion distance, session 2	0.0	0.1	0.1	-0.3	0.2
Locomotion velocity, session 3	0.2	0.2	0.4	-0.7	0.2
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	-0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.2	0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.1	0.5
Locomotion velocity, session 7	2.1	2.3	3.2	-1.8	1.2
Locomotion distance, session 7	0.4	0.6	1.1	-1.0	0.2
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.5	-0.2
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.1	0.8
Locomotion velocity, session 8	0.6	0.7	1.0	0.7	-1.0
Locomotion distance, session 8	1.4	2.0	3.4	0.8	-1.9
Degree of sensitization distance	0.3	0.3	0.6	-0.8	0.0
Degree of sensitization stereotypy	0.1	0.1	0.1	0.3	-0.4
Conditioned locomotion	0.4	0.5	0.7	0.8	-0.6
Cocaine response after cond. corrected	0.2	0.3	0.6	-0.8	0.1
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.3	-0.3
Cocaine response before conditioning	0.6	0.7	0.8	0.9	-0.7
Saline control response	0.2	0.2	0.4	-0.7	0.0
Bone: connectivity density	0.1	0.1	0.1	0.3	0.3
Bone: cortical apparent density	2.8	4.4	5.9	-1.7	2.4
Bone: cortical area	0.3	0.5	0.6	-0.8	0.6
Bone: cortical porosity	1.8	2.0	2.5	1.6	-1.2
Bone: cortical porosity	2.0	2.2	3.4	1.9	-1.0
Bone: cortical thickness	0.0	0.1	0.1	0.3	0.2
Bone: cortical thickness	0.5	0.6	1.1	0.4	-1.1
Bone: cortical tissue density	2.7	4.2	5.7	-1.7	2.4
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.4	0.4
Condit. Reinf. active-inactive response ratio	1.7	1.8	3.2	1.8	-0.7
Condit. Reinf. active responses	0.2	0.2	0.3	-0.4	0.5
Condit. Reinf. inactive responses	1.1	1.4	2.4	-1.6	0.6
Incentive salience index mean	0.1	0.1	0.2	-0.0	0.5
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.2	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.5	-0.7	0.7
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	0.1
Condit. Reinf. inactive responses	0.1	0.2	0.4	0.2	-0.6
Condit. Reinf. lever presses	0.2	0.2	0.4	-0.1	-0.7
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.0	-0.3
Conditioned reinforcement - actives	0.1	0.4	0.5	0.6	-0.7
Conditioned reinforcement - inactives	0.1	0.3	0.6	-0.8	0.1
Conditioned locomotion	0.0	0.0	0.0	-0.0	-0.1
Patch foraging indifference point 0 sec	0.1	0.3	0.5	-0.7	0.5
Patch foraging indifference point AUC	1.6	3.8	5.9	-2.4	1.3
Delay disc. indifference point, 0s delay	0.3	0.3	0.5	-0.4	0.7
Delay disc. indifference point, 16s delay	0.5	0.7	1.3	-0.3	1.1
Delay disc. indifference point, 2s delay	2.0	2.2	3.4	-1.8	1.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.2	-0.2
Delay disc. indifference point, 4s delay	1.5	1.5	1.8	-1.3	1.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.2	0.4	0.4
Indifference point function ln k	0.8	2.4	3.5	1.9	-1.1
Indifference point function log k	0.8	2.4	3.5	1.9	-1.1
Patch foraging total patch changes 0 sec	0.2	0.5	0.7	-0.8	0.5
Patch foraging total patch changes 12 sec	1.4	1.9	2.2	-1.5	1.3
Patch foraging total patch changes 18 sec	0.3	0.8	1.0	-1.0	0.7
Patch foraging total patch changes 24 sec	0.2	0.6	1.1	-1.1	0.3
Patch foraging total patch changes 6 sec	1.5	2.6	4.0	-2.0	1.1
Patch foraging time to switch 0 sec	0.4	1.5	3.0	1.7	-0.2
Patch foraging water rate 0 sec	0.3	1.3	2.1	-1.4	0.7
Patch foraging water rate 12 sec	0.2	0.8	1.5	0.2	-1.2
Patch foraging water rate 18 sec	0.1	0.3	0.4	-0.6	-0.5
Patch foraging water rate 24 sec	0.6	0.8	1.6	0.1	-1.3
Patch foraging water rate 6 sec	0.3	0.4	0.7	-0.8	0.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	-0.6	-0.4
Distance traveled before self-admin	0.0	0.0	0.1	0.2	-0.1
Distance traveled after self-admin	0.6	1.0	1.4	-0.7	-1.2
Extensor digitorum longus weight	4.5	18.0	30.6	5.5	-2.3
Bone: elastic displacement	1.7	2.2	2.6	1.4	-1.6
Bone: elastic work	1.9	2.5	3.2	1.3	-1.8
Bone: endosteal estimation	0.2	0.4	0.8	-0.9	-0.3
Bone: endosteal perimeter	0.0	0.1	0.2	-0.1	-0.5
Epididymis fat weight	1.0	5.2	7.8	-1.6	2.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.7	-0.3
Delta time in open arm before/after self-admin	1.0	1.2	1.2	-1.1	1.1
Diff in mean of infusions in LGA sessions	0.2	0.4	0.5	0.5	-0.7
Delay discount exponential model param	0.4	0.6	0.6	0.7	-0.8
Extinction: sum of active levers before priming	0.5	0.8	1.0	0.7	-1.0
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.8	0.5
Bone: final force	0.1	0.1	0.1	-0.3	0.4
Bone: final moment	0.1	0.1	0.1	-0.3	0.3
Food consumed during 24 hour testing period	0.3	0.6	0.9	-0.6	-1.0
Glucose	0.3	0.4	0.8	-0.9	0.0
Heart weight	0.2	0.3	0.6	0.8	0.1
Delay discount hyperbolic model param	0.5	0.7	0.8	0.9	-0.7
Intermittent access intake day 1-15 change	0.1	0.5	0.7	0.8	-0.6
Intermittent access intake escalation	0.1	0.5	0.8	0.9	-0.4
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.4	-0.0
Intermitt. access day 1 inactive lever presses	0.1	0.9	1.7	-1.3	-0.3
Intermitt. access day 15 inactive lever presses	0.3	1.8	3.2	-1.8	0.6
Intermitt. access escalation Index	0.1	0.3	0.6	0.7	-0.3
Intermittent access day 1 total infusions	0.1	0.4	0.6	0.3	-0.8
Intermittent access day 15 total infusions	0.4	0.9	1.3	0.7	-1.1
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.7	-0.1	-0.8
Intermittent access total infusions	0.3	0.3	0.6	0.3	-0.8
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	0.0
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	0.0
Intermittent access total locomotion	0.1	0.1	0.2	-0.1	0.5
Intermittent access standard deviation	0.1	0.3	0.4	-0.4	-0.7
Left kidney weight	0.0	0.0	0.0	0.1	-0.1
Right kidney weight	0.3	1.8	2.2	-1.1	1.5
Cocaine induced anxiety	0.0	0.1	0.2	-0.0	0.4
Post-drug Anxiety	0.2	0.2	0.3	-0.3	0.6
Baseline Anxiety	1.0	1.6	2.7	0.7	-1.6
Tail length	0.0	0.2	0.4	-0.6	-0.2
Length with tail	0.0	0.2	0.2	-0.5	-0.4
Length without tail	0.0	0.2	0.4	-0.2	-0.6
Times rat made contact with spout	0.6	0.7	0.7	-0.8	0.8
Lifetime Intake	0.2	0.3	0.3	0.5	-0.5
Liver weight, left	2.1	3.7	3.9	-2.0	1.9
Liver weight, right	1.1	1.9	2.6	-1.6	1.1
Locomotor activity	0.4	0.6	1.1	0.4	-1.1
Locomotor testing distance	1.1	2.6	3.4	1.4	-1.8
Locomotor testing rearing	0.6	2.4	3.2	1.2	-1.8
Locomotion in novel chamber	0.0	0.0	0.0	-0.0	0.1
Locomotion in novel chamber post-restriction	0.6	1.9	2.2	-1.3	1.5
Fecal boli incidents, locomotor time 1	0.5	1.3	2.1	1.4	-0.8
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.2	-0.2
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.2	1.1	-0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.5	0.0
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.3	0.2
Rest time, locomotor task time 1	0.5	0.8	1.4	0.4	-1.2
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	0.2
Vertical activity count, locomotor time 1	0.5	3.4	4.2	-1.6	2.0
Time >=10cm from walls, locomotor time 2	0.5	1.4	1.8	1.0	-1.4
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.2
Rest time, locomotor task time 2	0.8	1.4	2.2	0.7	-1.5
Distance moved, locomotor task time 2	0.2	0.2	0.2	0.4	0.5
Vertical activity count, locomotor time 2	0.8	1.9	2.5	-1.2	1.6
Light reinforcement 1	0.2	0.7	0.9	-1.0	0.7
Light reinforcement 2	0.0	0.0	0.1	0.0	0.3
Bone: marrow area	0.2	0.4	0.6	-0.8	-0.4
Bone: maximum diameter	0.3	0.7	1.0	-0.7	1.0
Bone: maximum force	0.0	0.0	0.1	-0.2	-0.1
Bone: maximum moment	0.0	0.1	0.1	-0.3	-0.1
Mean time between licks in bursts	0.3	1.5	3.1	1.7	-0.2
Mean num. licks in bursts	0.5	1.4	1.7	-1.3	1.0
Cd content in liver	2.1	2.4	4.0	2.0	-0.9
Co content in liver	0.0	0.0	0.1	0.3	-0.0
Cu content in liver	0.0	0.0	0.1	-0.2	0.2
Fe content in liver	0.3	0.4	0.7	-0.2	0.8
K content in liver	1.4	1.4	1.6	-1.3	1.1
Mg content in liver	1.3	1.4	1.6	-1.1	1.3
Mn content in liver	0.3	0.3	0.3	0.6	-0.5
Na content in liver	1.6	1.8	2.2	-1.5	1.2
Rb content in liver	0.2	0.2	0.3	0.6	0.3
Se content in liver	0.3	0.3	0.3	-0.6	0.5
Sr content in liver	2.6	2.2	2.6	1.4	-1.6
Zn content in liver	0.1	0.1	0.1	0.3	-0.1
Bone: minimum diameter	1.9	3.7	6.6	-2.6	0.9
Time in familiar zone, hab. session 1	0.4	0.5	0.8	0.3	-0.9
Time in novel zone, hab. session 1	1.3	1.5	2.6	-0.6	1.6
Total zone transitions, hab. session 1	0.1	0.2	0.2	-0.4	0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.3	-0.6	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.8	-0.3	-0.9
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3
Time in novel zone, hab. session 2	1.3	1.4	2.2	-0.8	1.5
Total zone transitions, hab. session 2	0.2	0.3	0.4	0.4	-0.6
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.0	-0.7
Locomotion velocity, hab. session 2	0.3	0.3	0.7	0.1	-0.8
Novel to familiar place preference ratio	1.7	2.3	3.0	-1.3	1.7
Novelty place preference	2.0	2.6	3.7	-1.2	1.9
Time in novel zone, NPP test	2.9	3.5	4.7	-1.5	2.2
Total zone transitions, NPP test	0.1	0.2	0.2	-0.3	0.5
Total locomotion distance, NPP test	0.3	0.4	0.6	0.3	-0.8
Locomotion velocity, NPP test	0.5	0.7	1.0	0.6	-1.0
Intraocular pressure	0.1	0.1	0.2	0.2	0.4
Delta distance traveled before/after self-admin	0.7	0.8	0.8	-0.9	-0.9
Delta ambulatory time before/after self-admin	0.3	0.6	0.9	-0.5	-1.0
Parametrial fat weight	2.3	5.5	6.2	-2.5	2.2
Pavlov. Cond. lever latency	1.3	1.6	1.9	1.4	-1.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.4	-0.6
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.4	0.5
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	0.6
Pavlov. Cond. latency score	0.4	0.5	0.6	-0.8	0.6
Pavlov. Cond. lever contacts	0.8	1.0	1.2	-1.1	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	1.5	1.9	2.1	-1.2	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.7	0.6
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.6	0.5
Pavlov. Cond. lever latency	1.5	2.1	2.3	-1.4	1.5
Pavlov. Cond. magazine entry latency	2.1	3.0	3.5	1.9	-1.6
Pavlov. Cond. change in total contacts	1.1	2.6	2.7	1.6	-1.6
Pavlov. Cond. index score	2.3	3.6	3.6	1.9	-1.9
Pavlov. Cond. latency score	3.0	4.8	5.0	2.2	-2.1
Pavlov. Cond. lever contacts	0.8	1.2	1.5	0.9	-1.2
Pavlov. Cond. magazine entry number	3.9	5.0	6.0	-2.4	2.0
Pavlov. Cond. intertrial magazine entries	2.0	4.3	5.2	-2.3	1.8
Pavlov. Cond. lever-magazine prob. diff.	2.2	3.3	3.4	1.8	-1.8
Pavlov. Cond. response bias	1.6	2.2	2.2	1.5	-1.5
Time in closed arm before self-admin	0.2	0.3	0.4	-0.6	0.5
Time in closed arm after self-admin	0.6	0.7	0.8	0.8	-0.9
Time in open arm before self-admin	2.6	3.2	3.4	1.7	-1.8
Time in open arm after self-admin	1.7	1.9	2.2	-1.5	1.3
Bone: periosteal estimation	0.2	0.4	0.7	-0.9	0.2
Bone: periosteal perimeter	0.0	0.1	0.1	-0.3	-0.2
Bone: post-yield work	0.2	0.3	0.3	-0.5	0.6
Progressive ratio test 1 active lever presses	0.2	0.3	0.4	0.6	-0.5
Progressive ratio test 1 breakpoint	0.3	0.4	0.5	0.6	-0.7
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.6	-1.3	0.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.2	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	-0.5
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.7	-0.8	-0.2
Incentive Sensitization - Responses	0.0	0.0	0.0	0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.3	-0.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.1	-0.7
Progressive ratio	0.0	0.1	0.2	0.5	-0.2
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.3	0.1
Seeking ratio, punishment vs. effort	0.5	1.1	1.4	-1.2	0.9
Retroperitoneal fat weight	0.9	4.2	5.1	-1.8	2.3
Reaction time number correct	0.0	0.1	0.1	0.3	-0.2
Reaction time mean minus median	0.1	0.4	0.7	-0.2	0.9
Reaction time mean minus median AUC	0.3	1.7	2.9	-0.8	1.7
Reaction time num false alarms	1.3	2.2	2.9	-1.2	1.7
Reaction time num false alarms AUC	0.8	1.8	2.6	-1.0	1.6
Reaction time trials correct on left	0.0	0.1	0.1	0.3	-0.2
Reaction time trials on left	0.0	0.1	0.2	0.4	-0.2
Reaction time mean	0.1	0.1	0.2	0.1	0.5
Reaction time mean AUC	0.1	0.2	0.5	-0.0	0.7
Median of all reaction times	0.0	0.1	0.1	0.2	0.2
Reaction time omissions	0.4	0.6	1.1	1.1	-0.3
Reaction time false alarm rate	1.2	1.7	2.4	-1.0	1.6
Reaction time premature initiation rate	0.5	0.8	0.8	-0.9	0.9
Reaction time premature initiations	0.3	0.9	1.0	-0.9	1.0
Std. dev. reaction times	0.1	0.2	0.4	0.1	0.6
Reaction time trials completed	0.0	0.1	0.2	0.4	-0.2
Reaction time trials AUC	0.0	0.1	0.1	0.3	-0.1
Run reversals in cocaine runway, females	0.4	0.5	1.0	-1.0	0.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.4	-0.2
Latency to leave start box in cocaine runway	1.4	1.9	3.3	-1.8	0.7
Latency to leave start box in cocaine runway, F	3.2	4.0	6.2	-2.5	1.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.0	-0.7
Std. dev. time between licks in bursts	0.9	1.8	2.6	1.6	-1.0
Total sessions with >9 infusions	0.5	0.6	1.2	1.1	0.2
Short access day 1 total inactive lever presses	0.2	0.5	0.9	-0.2	-0.9
Short access day 10 total inactive lever presses	0.1	0.7	1.0	-0.7	-1.0
Short access day 1 total infusions	0.1	0.1	0.2	-0.4	0.3
Short access day 10 total infusions	0.4	0.6	0.6	0.7	-0.8
Short access total infusions	0.2	0.3	0.5	0.7	-0.2
Short access day 1 locomotion	0.4	0.7	0.8	0.8	-0.9
Short access day 10 total locomotion	0.0	0.0	0.1	0.1	0.2
Short access total locomotion	0.1	0.1	0.3	0.5	0.1
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.0	-0.4
Compulsive drug intake	0.1	0.2	0.3	-0.6	0.2
One hour access (shock baseline)	0.0	0.0	0.0	0.1	-0.0
Social response proportion	2.5	3.2	4.3	-2.1	1.4
Social responses	1.1	1.4	1.9	-1.4	1.0
Social time	0.6	1.0	1.6	-1.2	0.7
Soleus weight	1.7	5.1	5.9	2.1	-2.4
Bone: stiffness	1.5	2.7	2.8	-1.7	1.6
Tibialis anterior weight	1.1	3.8	7.3	2.7	-0.5
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.6	-0.7	0.0
Time to tail flick, vehicle, after self-admin	0.5	1.1	1.9	0.5	-1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.5	-0.5
Time to tail flick, test, after self-admin	0.6	0.7	1.1	-1.0	0.5
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	-0.0
Delta time to tail flick, test, before/after SA	1.4	1.7	2.1	-1.4	1.1
Tibia length	0.2	0.7	0.7	-0.8	0.9
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.0
Ambulatory time after self-admin	0.4	0.7	0.8	-0.9	-0.7
Bone: tissue strength	0.3	0.4	0.7	-0.8	0.2
Total heroin consumption	0.2	0.2	0.4	0.1	-0.7
Bone: trabecular number	0.3	0.6	0.9	-0.6	0.9
Bone: trabecular spacing	0.9	1.3	1.9	-0.8	1.4
Bone: trabecular thickness	0.2	0.3	0.5	0.0	-0.7
Bone: trabecular tissue density	0.2	0.3	0.6	0.1	0.8
Water consumed over 24 hours	0.3	0.5	1.0	-1.0	0.1
Number of responses in last shaping day	0.1	0.1	0.2	0.0	0.5