Hub : Genes

Ugt2b35

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Ugt2b35	0.84	0.11	0.0e+00	0.51	0.5	0.49	0.49	5.6e-65	1.7e-64	2.2e-62	4.5e-61
2	Liver	gene expression	Ugt2b35	0.41	0.14	0.0e+00	0.23	0.28	0.27	0.26	3.2e-25	2.1e-31	1.4e-29	5.6e-29

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.2	0.3	0.3	0.6	-0.5
Area under the delay curve	0.0	0.0	0.0	0.1	-0.2
BMI with tail	1.4	4.5	5.2	2.0	-2.3
BMI without tail	0.0	0.0	0.0	-0.1	-0.2
Body weight	0.2	0.7	0.9	0.8	-0.9
Weight adjusted by age	1.7	1.9	2.2	1.5	-1.3
Bone surface	0.0	0.1	0.1	0.4	-0.1
Bone volume	0.1	0.1	0.1	-0.3	0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.2	-0.5	0.4
Number of licking bursts	0.1	0.1	0.1	0.3	-0.3
Context. condit. distance diff. score	0.1	0.1	0.3	-0.1	0.5
Locomotion velocity, session 1	0.6	0.7	0.9	0.7	-0.9
Locomotion distance, session 1	0.3	0.3	0.4	-0.5	0.6
Locomotion velocity, session 2	0.0	0.1	0.1	-0.2	0.3
Locomotion distance, session 2	0.1	0.2	0.2	-0.4	0.5
Locomotion velocity, session 3	0.7	0.9	0.9	-0.9	0.9
Locomotion distance, session 3	0.0	0.0	0.0	-0.2	0.1
Stereotopy head waving bouts, day 3	0.6	0.7	0.8	0.8	-0.9
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.3	-0.3
Locomotion velocity, session 7	2.6	2.8	3.0	-1.7	1.6
Locomotion distance, session 7	1.6	2.0	2.0	-1.4	1.4
Stereotopy head waving bouts, day 7	0.3	0.4	0.4	0.6	-0.6
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.6	-0.7
Locomotion velocity, session 8	0.0	0.0	0.0	0.2	0.0
Locomotion distance, session 8	0.6	0.9	1.2	-0.7	1.1
Degree of sensitization distance	1.3	1.3	1.3	-1.1	1.2
Degree of sensitization stereotypy	0.0	0.0	0.0	0.2	-0.2
Conditioned locomotion	0.3	0.4	0.4	0.6	-0.6
Cocaine response after cond. corrected	0.8	0.9	1.0	-1.0	1.0
Cocaine response after cond. not corrected	0.8	0.9	0.9	-1.0	1.0
Cocaine response before conditioning	0.1	0.1	0.2	0.4	-0.3
Saline control response	0.7	0.9	1.0	-0.9	1.0
Bone: connectivity density	0.5	0.7	0.7	0.8	-0.9
Bone: cortical apparent density	0.1	0.1	0.3	-0.5	0.0
Bone: cortical area	0.2	0.3	0.3	-0.5	0.5
Bone: cortical porosity	2.1	2.3	2.5	1.6	-1.4
Bone: cortical porosity	3.5	3.8	4.0	2.0	-1.9
Bone: cortical thickness	0.3	0.6	0.6	0.7	-0.8
Bone: cortical thickness	0.1	0.1	0.2	-0.3	0.4
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	0.9	0.8	-1.0
Condit. Reinf. active-inactive response ratio	3.6	3.9	4.0	2.0	-2.0
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.1
Condit. Reinf. inactive responses	2.9	3.4	3.5	-1.9	1.8
Incentive salience index mean	0.1	0.1	0.1	0.2	-0.3
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.3	-0.5	0.5
Condit. Reinf. active responses	0.1	0.2	0.2	-0.3	0.5
Condit. Reinf. inactive responses	0.3	0.3	0.4	-0.5	0.7
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.7	0.9
Condit. Reinf. lever reinforcers received	0.2	0.2	0.3	-0.4	0.6
Conditioned reinforcement - actives	0.2	0.2	0.2	0.5	-0.4
Conditioned reinforcement - inactives	1.3	1.4	1.4	-1.2	1.2
Conditioned locomotion	0.0	0.0	0.0	-0.0	0.0
Patch foraging indifference point 0 sec	0.4	0.6	0.6	-0.8	0.8
Patch foraging indifference point AUC	3.1	3.6	3.9	-2.0	1.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.2	-0.4
Delay disc. indifference point, 16s delay	0.7	0.7	0.8	0.8	-0.9
Delay disc. indifference point, 2s delay	2.8	3.1	3.2	-1.8	1.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.5	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.7	0.5
Delay disc. indifference point, 8s delay	1.6	1.6	1.6	1.3	-1.3
Indifference point function ln k	1.2	1.7	1.9	1.4	-1.2
Indifference point function log k	1.2	1.7	1.9	1.4	-1.2
Patch foraging total patch changes 0 sec	0.4	0.7	0.7	-0.8	0.8
Patch foraging total patch changes 12 sec	0.4	0.5	0.6	-0.7	0.6
Patch foraging total patch changes 18 sec	0.2	0.2	0.3	-0.5	0.4
Patch foraging total patch changes 24 sec	1.1	1.3	1.4	-1.2	1.1
Patch foraging total patch changes 6 sec	1.6	2.4	2.6	-1.6	1.5
Patch foraging time to switch 0 sec	4.3	6.6	6.7	2.6	-2.5
Patch foraging water rate 0 sec	1.9	3.0	3.1	-1.8	1.7
Patch foraging water rate 12 sec	0.4	0.7	0.7	-0.8	0.8
Patch foraging water rate 18 sec	2.2	3.0	3.1	-1.7	1.8
Patch foraging water rate 24 sec	1.2	1.7	2.0	-1.2	1.4
Patch foraging water rate 6 sec	0.6	0.9	0.9	-1.0	0.9
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	1.7	-1.1	1.3
Distance traveled before self-admin	0.4	0.4	0.5	-0.7	0.7
Distance traveled after self-admin	3.1	3.5	3.8	-1.8	1.9
Extensor digitorum longus weight	11.2	44.2	44.4	6.6	-6.7
Bone: elastic displacement	0.4	0.4	0.6	0.8	-0.6
Bone: elastic work	0.1	0.1	0.2	0.5	-0.3
Bone: endosteal estimation	1.6	3.4	4.0	-1.7	2.0
Bone: endosteal perimeter	0.3	0.7	0.9	-0.7	0.9
Epididymis fat weight	0.1	0.2	0.2	0.4	-0.5
Delta time in closed arm before/after self-admin	1.9	1.9	1.9	1.4	-1.3
Delta time in open arm before/after self-admin	1.8	1.7	1.8	-1.4	1.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	-0.1
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.0
Extinction: sum of active levers before priming	0.6	0.6	0.7	-0.7	0.8
Active lever presses in extinction session 6	0.8	0.8	0.8	-0.8	0.9
Bone: final force	0.0	0.0	0.0	-0.1	0.2
Bone: final moment	0.0	0.0	0.0	-0.2	0.2
Food consumed during 24 hour testing period	2.9	3.6	3.9	-1.8	2.0
Glucose	1.1	1.7	1.8	-1.2	1.3
Heart weight	0.8	1.1	1.3	1.1	-1.0
Delay discount hyperbolic model param	0.1	0.1	0.2	0.4	-0.3
Intermittent access intake day 1-15 change	1.8	1.8	2.1	1.4	-1.2
Intermittent access intake escalation	0.8	0.8	0.9	1.0	-0.8
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.0	0.2
Intermitt. access day 1 inactive lever presses	1.2	1.3	1.4	-1.1	1.2
Intermitt. access day 15 inactive lever presses	1.8	2.0	2.1	-1.4	1.4
Intermitt. access escalation Index	1.3	1.1	1.1	1.1	-1.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	0.2
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	0.0
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.2	-0.4	0.5
Intermittent access total infusions	0.0	0.0	0.0	-0.2	0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.1
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.1	0.1
Intermittent access total locomotion	0.1	0.1	0.1	0.3	-0.3
Intermittent access standard deviation	0.1	0.1	0.1	-0.2	0.3
Left kidney weight	0.2	0.6	0.7	-0.7	0.8
Right kidney weight	0.3	0.9	1.0	-1.0	0.9
Cocaine induced anxiety	0.1	0.1	0.1	0.3	-0.3
Post-drug Anxiety	0.0	0.0	0.0	-0.1	0.0
Baseline Anxiety	0.1	0.1	0.1	-0.3	0.3
Tail length	0.1	0.3	0.3	-0.5	0.6
Length with tail	0.5	1.9	2.1	-1.3	1.4
Length without tail	0.2	0.4	0.4	-0.6	0.7
Times rat made contact with spout	0.2	0.3	0.3	-0.6	0.4
Lifetime Intake	0.0	0.0	0.0	0.0	-0.0
Liver weight, left	2.5	4.0	4.4	-2.1	1.9
Liver weight, right	3.1	5.1	5.3	-2.3	2.2
Locomotor activity	0.3	0.5	0.6	-0.6	0.8
Locomotor testing distance	0.1	0.2	0.2	-0.3	0.5
Locomotor testing rearing	0.0	0.0	0.0	0.0	0.2
Locomotion in novel chamber	0.0	0.1	0.1	-0.3	0.1
Locomotion in novel chamber post-restriction	1.0	1.1	1.3	-1.1	1.0
Fecal boli incidents, locomotor time 1	1.2	1.4	1.5	1.2	-1.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	-0.1
Time >=10cm from walls, locomotor time 1	1.3	1.4	1.4	1.2	-1.2
Bouts of movement, locomotor time 1	1.0	1.1	1.2	1.0	-1.1
Total resting periods, locomotor time 1	0.7	0.7	0.9	0.8	-0.9
Rest time, locomotor task time 1	0.7	0.8	0.8	-0.9	0.9
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.4	-0.3
Vertical activity count, locomotor time 1	0.1	0.2	0.2	-0.5	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.3	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.2
Rest time, locomotor task time 2	0.4	0.5	0.6	-0.6	0.8
Distance moved, locomotor task time 2	1.3	1.5	1.5	1.2	-1.2
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1
Light reinforcement 1	0.7	1.2	1.3	-1.1	1.1
Light reinforcement 2	0.0	0.0	0.0	-0.0	-0.1
Bone: marrow area	1.4	3.1	3.7	-1.6	1.9
Bone: maximum diameter	0.0	0.0	0.0	0.0	-0.1
Bone: maximum force	0.2	0.3	0.4	-0.5	0.6
Bone: maximum moment	0.2	0.4	0.5	-0.6	0.7
Mean time between licks in bursts	5.2	7.4	7.5	2.7	-2.7
Mean num. licks in bursts	0.8	0.9	1.1	-1.0	0.9
Cd content in liver	2.0	2.2	2.3	1.5	-1.5
Co content in liver	0.0	0.0	0.0	-0.1	0.2
Cu content in liver	0.4	0.5	0.5	-0.7	0.7
Fe content in liver	0.6	0.8	0.9	0.8	-0.9
K content in liver	1.2	1.1	1.3	-1.1	1.0
Mg content in liver	1.2	1.2	1.5	-1.2	1.0
Mn content in liver	0.1	0.1	0.1	0.3	-0.3
Na content in liver	1.0	1.1	1.4	-1.2	0.9
Rb content in liver	0.9	1.1	1.1	1.0	-1.1
Se content in liver	0.0	0.0	0.1	-0.2	0.2
Sr content in liver	0.3	0.3	0.3	0.6	-0.5
Zn content in liver	1.1	1.2	1.2	-1.0	1.1
Bone: minimum diameter	5.3	9.9	10.4	-3.1	3.2
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.3	0.5
Time in novel zone, hab. session 1	0.6	0.6	0.8	0.6	-0.9
Total zone transitions, hab. session 1	0.3	0.5	0.5	-0.7	0.7
Total locomotion distance, hab. session 1	2.3	3.2	3.5	-1.7	1.9
Locomotion velocity, hab. session 1	1.9	2.6	3.0	-1.5	1.7
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.1	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.2	-0.4
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.1	0.2
Total locomotion distance, hab. session 2	0.7	0.9	1.0	-0.9	1.0
Locomotion velocity, hab. session 2	0.7	1.0	1.1	-0.9	1.1
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.4	0.1
Novelty place preference	0.0	0.0	0.0	-0.1	-0.1
Time in novel zone, NPP test	0.1	0.1	0.1	-0.4	0.1
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	0.2
Total locomotion distance, NPP test	0.3	0.4	0.5	-0.6	0.7
Locomotion velocity, NPP test	0.1	0.1	0.1	-0.2	0.3
Intraocular pressure	0.9	1.2	1.3	1.1	-1.1
Delta distance traveled before/after self-admin	0.5	0.5	0.6	-0.6	0.8
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.3	0.4
Parametrial fat weight	1.6	3.2	3.5	-1.9	1.7
Pavlov. Cond. lever latency	0.8	1.0	1.1	1.0	-0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	0.1
Pavlov. Cond. index score	0.2	0.3	0.3	-0.6	0.5
Pavlov. Cond. latency score	0.4	0.5	0.5	-0.7	0.6
Pavlov. Cond. lever contacts	0.9	1.0	1.1	-1.1	1.0
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.4	-0.7	0.6
Pavlov. Cond. response bias	0.4	0.4	0.5	-0.7	0.6
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	0.2
Pavlov. Cond. magazine entry latency	0.8	0.9	1.1	1.0	-0.9
Pavlov. Cond. change in total contacts	0.4	0.5	0.7	0.8	-0.6
Pavlov. Cond. index score	0.6	0.8	1.0	1.0	-0.7
Pavlov. Cond. latency score	1.0	1.2	1.5	1.2	-1.0
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.3	-0.0
Pavlov. Cond. magazine entry number	1.5	1.8	2.1	-1.4	1.3
Pavlov. Cond. intertrial magazine entries	1.7	2.2	2.4	-1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	0.9	-0.7
Pavlov. Cond. response bias	0.4	0.5	0.7	0.8	-0.6
Time in closed arm before self-admin	0.8	0.9	0.9	-0.9	0.9
Time in closed arm after self-admin	0.4	0.4	0.6	0.7	-0.5
Time in open arm before self-admin	1.3	1.4	1.8	1.3	-1.1
Time in open arm after self-admin	1.4	1.6	1.7	-1.3	1.2
Bone: periosteal estimation	0.7	1.4	1.6	-1.1	1.3
Bone: periosteal perimeter	0.4	0.7	0.7	-0.8	0.9
Bone: post-yield work	0.1	0.2	0.2	-0.4	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	-0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.2	0.4	-0.4
Progressive ratio test 1 inactive lever presses	2.9	3.1	3.2	-1.8	1.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.0	-0.0
Progressive ratio test 2 inactive lever presses	1.1	1.2	1.3	-1.1	1.1
Incentive Sensitization - Responses	0.1	0.1	0.1	0.2	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.2	-0.2
Sum of active levers in priming session hrs 5-6	1.1	1.0	1.0	-1.0	1.0
Progressive ratio	0.4	0.5	0.6	0.8	-0.6
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.0	-0.3
Seeking ratio, punishment vs. effort	0.5	0.6	0.8	-0.9	0.6
Retroperitoneal fat weight	0.1	0.4	0.6	-0.8	0.5
Reaction time number correct	0.0	0.0	0.0	0.1	-0.2
Reaction time mean minus median	0.6	0.8	0.8	0.8	-0.9
Reaction time mean minus median AUC	0.4	0.5	0.7	0.6	-0.8
Reaction time num false alarms	0.1	0.1	0.2	-0.5	0.2
Reaction time num false alarms AUC	0.0	0.0	0.0	-0.2	-0.1
Reaction time trials correct on left	0.0	0.0	0.0	0.1	-0.2
Reaction time trials on left	0.0	0.0	0.1	0.2	-0.2
Reaction time mean	0.8	1.1	1.2	1.0	-1.1
Reaction time mean AUC	0.6	0.8	0.9	0.9	-0.9
Median of all reaction times	0.7	1.0	1.0	1.0	-1.0
Reaction time omissions	1.6	2.1	2.2	1.4	-1.5
Reaction time false alarm rate	0.0	0.0	0.0	-0.2	-0.0
Reaction time premature initiation rate	0.3	0.4	0.4	-0.7	0.5
Reaction time premature initiations	0.3	0.4	0.5	-0.7	0.5
Std. dev. reaction times	0.5	0.7	0.7	0.8	-0.9
Reaction time trials completed	0.0	0.0	0.1	0.2	-0.2
Reaction time trials AUC	0.1	0.1	0.1	0.3	-0.3
Run reversals in cocaine runway, females	3.4	3.3	3.4	-1.8	1.8
Run reversals in cocaine runway, males	0.2	0.2	0.2	0.5	-0.4
Latency to leave start box in cocaine runway	3.6	3.9	4.3	-2.1	1.9
Latency to leave start box in cocaine runway, F	5.2	5.7	6.1	-2.5	2.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.3
Std. dev. time between licks in bursts	1.5	1.8	2.1	1.4	-1.2
Total sessions with >9 infusions	1.6	1.8	1.8	1.4	-1.3
Short access day 1 total inactive lever presses	1.3	1.4	1.6	-1.1	1.3
Short access day 10 total inactive lever presses	1.3	1.4	1.6	-1.1	1.3
Short access day 1 total infusions	0.1	0.1	0.1	-0.3	0.3
Short access day 10 total infusions	0.0	0.0	0.0	-0.0	-0.1
Short access total infusions	0.2	0.2	0.2	0.4	-0.5
Short access day 1 locomotion	0.2	0.2	0.2	0.4	-0.4
Short access day 10 total locomotion	0.2	0.3	0.3	0.5	-0.5
Short access total locomotion	0.6	0.6	0.6	0.7	-0.8
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	0.5
Compulsive drug intake	0.3	0.3	0.4	-0.7	0.5
One hour access (shock baseline)	0.0	0.0	0.0	0.0	-0.0
Social response proportion	2.5	2.7	3.1	-1.8	1.5
Social responses	0.9	1.2	1.5	-1.2	0.9
Social time	1.1	1.4	1.7	-1.3	1.1
Soleus weight	0.4	1.0	1.5	1.2	-0.8
Bone: stiffness	0.7	1.1	1.1	-1.1	1.0
Tibialis anterior weight	4.9	16.8	17.2	4.1	-4.1
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.6	-0.7	0.8
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.8	-0.6	0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	0.1
Time to tail flick, test, after self-admin	1.7	1.7	1.9	-1.2	1.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	0.3
Delta time to tail flick, test, before/after SA	1.1	1.0	1.1	-1.0	0.9
Tibia length	0.1	0.2	0.3	-0.5	0.5
Ambulatory time before self-admin	0.6	0.6	0.7	-0.8	0.8
Ambulatory time after self-admin	3.3	3.6	3.9	-1.8	2.0
Bone: tissue strength	1.1	1.1	1.2	-1.1	1.0
Total heroin consumption	1.7	1.9	2.1	-1.3	1.5
Bone: trabecular number	0.1	0.1	0.2	0.3	-0.4
Bone: trabecular spacing	0.0	0.0	0.1	0.0	-0.3
Bone: trabecular thickness	0.1	0.2	0.2	-0.3	0.5
Bone: trabecular tissue density	0.4	0.6	0.7	0.7	-0.8
Water consumed over 24 hours	2.1	2.5	2.6	-1.6	1.6
Number of responses in last shaping day	0.4	0.4	0.5	0.6	-0.7