Ugt2b15

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr14_21123619_21125093	0.16	0.09	2.3e-15	0.13	0.11	0.13	0.13	5.7e-14	5.6e-12	2.0e-14	4.8e-14
2	Liver	gene expression	Ugt2b15	0.39	0.21	0.0e+00	0.12	0.13	0.13	0.13	1.1e-12	3.9e-14	3.6e-14	4.0e-14
3	Liver	intron excision ratio	chr14_21172901_21174383	0.24	0.13	0.0e+00	0.14	0.17	0.19	0.19	8.5e-16	1.6e-18	2.8e-20	5.3e-21
4	Liver	intron excision ratio	chr14_21126776_21134214	0.68	0.11	0.0e+00	0.5	0.42	0.51	0.51	3.1e-63	1.0e-50	1.6e-65	9.1e-66
5	Liver	mRNA stability	Ugt2b15	0.4	0.27	0.0e+00	0.09	0.21	0.2	0.21	8.1e-10	5.9e-23	1.0e-21	6.0e-23
6	Liver	intron excision ratio	chr14_21076424_21087889	0.79	0.06	0.0e+00	0.35	0.24	0.38	0.37	2.3e-40	1.2e-26	5.0e-45	1.5e-42

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.2	0.0	-0.1
Area under the delay curve	0.1	0.1	0.6	-0.1	-0.3	-0.2	-0.3	0.8	0.0
BMI with tail	2.0	7.0	9.0	-2.9	1.4	-2.9	-3.0	2.8	-2.5
BMI without tail	1.1	5.8	7.9	-2.8	1.1	-2.6	-2.8	2.6	-2.2
Body weight	0.4	1.7	3.7	-1.3	-0.0	-1.2	-1.4	1.9	-1.1
Weight adjusted by age	0.4	1.0	2.7	-1.2	1.7	-0.7	-0.8	-0.4	-0.8
Bone surface	0.1	0.3	1.1	0.3	0.4	0.4	0.3	-1.0	0.1
Bone volume	0.2	0.5	0.7	0.8	-0.6	0.7	0.7	-0.6	0.7
Breakpoint value in progressive ratio session	0.2	0.3	0.6	0.6	-0.8	0.2	0.4	-0.0	0.7
Number of licking bursts	0.0	0.1	0.2	-0.4	0.5	-0.3	-0.3	0.1	-0.4
Context. condit. distance diff. score	1.5	1.8	5.8	0.8	0.5	1.6	1.2	-2.4	0.4
Locomotion velocity, session 1	1.4	1.6	3.0	-1.2	0.2	-1.5	-1.3	1.7	-1.0
Locomotion distance, session 1	0.2	0.3	0.4	0.6	-0.6	0.6	0.6	-0.5	0.4
Locomotion velocity, session 2	0.1	0.1	0.2	0.2	0.0	0.4	0.2	-0.4	0.0
Locomotion distance, session 2	0.1	0.1	0.2	0.4	-0.4	0.4	0.4	-0.2	0.2
Locomotion velocity, session 3	0.6	0.7	0.9	0.8	-0.8	0.8	0.9	-0.6	0.9
Locomotion distance, session 3	0.1	0.1	0.2	0.2	-0.1	0.3	0.3	-0.4	0.3
Stereotopy head waving bouts, day 3	0.9	1.0	1.3	-1.1	0.6	-1.1	-1.0	1.1	-1.0
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.5	0.1	-0.6	-0.4	0.6	-0.4
Locomotion velocity, session 7	1.7	1.9	3.9	1.4	-2.0	1.3	1.2	-0.1	1.6
Locomotion distance, session 7	1.5	1.9	2.8	1.6	-1.3	1.7	1.4	-0.8	1.3
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	-0.6	0.8	-0.8	-0.4	0.3	-0.5
Stereotopy head waving duration, day 7	0.6	0.8	1.7	-0.9	0.4	-1.3	-0.7	1.1	-0.6
Locomotion velocity, session 8	0.2	0.2	0.9	0.2	0.4	0.5	0.3	-0.9	0.1
Locomotion distance, session 8	1.7	2.5	6.0	1.3	-0.2	2.0	1.6	-2.4	0.8
Degree of sensitization distance	1.2	1.3	2.0	1.4	-1.0	1.4	1.1	-0.6	1.0
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.0	0.3	-0.2	0.2	-0.2	0.1
Conditioned locomotion	0.2	0.2	0.4	-0.5	0.7	-0.3	-0.4	-0.3	-0.6
Cocaine response after cond. corrected	0.5	0.7	1.0	0.9	-0.9	0.8	1.0	-0.5	0.9
Cocaine response after cond. not corrected	0.6	0.8	1.0	0.9	-0.7	1.0	1.0	-1.0	0.9
Cocaine response before conditioning	0.2	0.2	0.5	-0.3	0.7	-0.2	-0.4	-0.6	-0.4
Saline control response	0.5	0.7	0.9	0.8	-0.9	0.9	0.8	-0.6	0.9
Bone: connectivity density	0.2	0.3	0.5	-0.7	0.3	-0.6	-0.7	0.4	-0.5
Bone: cortical apparent density	0.9	1.4	5.0	-0.6	-0.9	-1.2	-0.9	2.2	-0.1
Bone: cortical area	0.2	0.3	0.6	0.6	-0.8	0.5	0.4	0.4	0.6
Bone: cortical porosity	0.9	1.0	2.1	-1.2	1.4	-0.7	-0.9	-0.4	-1.0
Bone: cortical porosity	2.4	2.6	3.8	-1.9	2.0	-1.5	-1.7	0.3	-1.7
Bone: cortical thickness	0.2	0.4	0.7	-0.6	0.4	-0.6	-0.8	0.7	-0.6
Bone: cortical thickness	0.6	0.7	1.7	0.8	-0.0	0.8	0.8	-1.3	0.7
Bone: cortical tissue density	0.9	1.5	5.1	-0.7	-0.8	-1.3	-0.9	2.3	-0.2
Condit. Reinf. active minus inactive responses	0.9	1.1	1.5	-1.2	0.6	-0.9	-1.1	1.0	-1.2
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.7	-1.9	1.9	-1.5	-1.8	0.7	-1.9
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.1	0.4	-0.1
Condit. Reinf. inactive responses	1.4	1.8	2.7	1.5	-1.6	1.3	1.5	-0.6	1.4
Incentive salience index mean	0.2	0.2	0.4	-0.5	0.1	-0.4	-0.4	0.6	-0.5
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2	-0.2	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.5	0.1	0.3	-0.1	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	0.4	-0.7	0.3	0.4	-0.0	0.5
Condit. Reinf. active responses	0.1	0.2	0.3	0.4	-0.4	0.5	0.5	-0.5	0.3
Condit. Reinf. inactive responses	0.4	0.6	1.2	0.6	-0.3	1.0	0.8	-1.1	0.4
Condit. Reinf. lever presses	1.2	1.7	2.9	1.3	-0.7	1.4	1.4	-1.7	1.2
Condit. Reinf. lever reinforcers received	0.3	0.5	1.0	0.5	-0.4	0.7	0.7	-1.0	0.5
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.1	0.4	0.4	-0.1	-0.4	-0.2
Conditioned reinforcement - inactives	0.3	0.7	1.6	0.7	-0.9	0.6	0.7	-0.6	1.2
Conditioned locomotion	0.1	0.1	0.5	0.3	-0.1	0.7	0.2	-0.0	-0.3
Patch foraging indifference point 0 sec	0.2	0.5	0.8	0.7	-0.9	0.6	0.6	-0.3	0.8
Patch foraging indifference point AUC	1.3	3.0	5.8	1.8	-2.4	1.6	1.6	0.1	1.9
Delay disc. indifference point, 0s delay	0.1	0.2	0.5	-0.3	-0.2	-0.4	-0.4	0.7	-0.1
Delay disc. indifference point, 16s delay	1.0	1.4	2.7	-1.1	0.3	-1.4	-1.3	1.6	-0.8
Delay disc. indifference point, 2s delay	2.7	3.0	4.3	2.0	-2.1	1.9	1.8	-0.4	1.7
Delay disc. indifference point, 24s delay	0.0	0.1	0.1	-0.2	0.3	-0.1	-0.2	0.1	-0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.2	-0.9	0.1	0.1	0.9	0.7
Delay disc. indifference point, 8s delay	1.0	1.7	2.3	-1.4	0.8	-1.3	-1.5	1.3	-1.3
Indifference point function ln k	0.5	1.4	3.0	-1.2	1.7	-1.0	-1.1	-0.2	-1.4
Indifference point function log k	0.5	1.4	3.0	-1.2	1.7	-1.0	-1.1	-0.2	-1.4
Patch foraging total patch changes 0 sec	0.2	0.6	1.1	0.8	-1.0	0.7	0.7	-0.3	0.8
Patch foraging total patch changes 12 sec	0.5	0.7	1.8	0.7	-1.3	0.6	0.4	0.9	0.5
Patch foraging total patch changes 18 sec	0.2	0.4	1.1	0.5	-1.0	0.3	0.4	0.1	0.8
Patch foraging total patch changes 24 sec	0.4	1.2	1.6	1.3	-1.3	1.3	1.1	-0.5	1.0
Patch foraging total patch changes 6 sec	1.4	2.4	4.2	1.8	-2.0	1.3	1.5	-0.1	1.8
Patch foraging time to switch 0 sec	1.4	5.5	7.1	-2.7	2.3	-2.6	-2.5	1.4	-2.3
Patch foraging water rate 0 sec	0.6	2.3	3.6	1.9	-1.7	1.7	1.7	-0.4	1.3
Patch foraging water rate 12 sec	0.3	1.0	1.8	1.1	-0.1	1.3	1.1	-1.3	0.6
Patch foraging water rate 18 sec	1.3	2.8	3.9	2.0	-1.2	2.0	1.9	-1.5	1.4
Patch foraging water rate 24 sec	2.3	3.3	4.7	2.0	-0.7	2.1	2.1	-2.2	1.4
Patch foraging water rate 6 sec	0.7	1.0	1.6	1.2	-1.0	1.2	1.1	-0.3	0.9
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	1.8	0.7	-0.8	0.8	0.9	-1.1	1.3
Distance traveled before self-admin	0.0	0.0	0.2	0.1	-0.1	0.1	0.2	-0.4	0.0
Distance traveled after self-admin	3.9	6.9	9.1	2.8	-1.6	2.7	3.0	-2.8	2.6
Extensor digitorum longus weight	8.0	31.9	44.1	-6.4	6.6	-5.7	-5.9	2.4	-5.9
Bone: elastic displacement	0.3	0.4	1.5	-0.1	0.9	0.3	0.1	-1.2	-0.1
Bone: elastic work	0.5	0.6	2.8	0.0	0.7	0.5	0.3	-1.7	0.2
Bone: endosteal estimation	1.3	3.1	4.0	2.0	-1.3	1.9	2.0	-1.4	1.7
Bone: endosteal perimeter	0.4	0.9	1.2	1.1	-0.4	0.8	1.1	-1.0	1.0
Epididymis fat weight	0.4	2.0	7.4	-0.9	-0.9	-1.2	-1.1	2.7	-0.6
Delta time in closed arm before/after self-admin	1.1	1.0	1.3	-1.0	1.1	-1.1	-0.9	0.9	-0.9
Delta time in open arm before/after self-admin	0.2	0.3	1.1	0.4	-1.0	0.3	0.3	0.3	0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.2	0.4	0.1	0.2	-0.5	0.1
Delay discount exponential model param	0.1	0.1	0.5	-0.1	0.4	-0.0	0.1	-0.7	-0.2
Extinction: sum of active levers before priming	0.2	0.3	1.0	0.4	0.4	0.4	0.6	-1.0	0.2
Active lever presses in extinction session 6	0.5	0.5	0.9	0.7	-1.0	0.6	0.7	-0.1	0.7
Bone: final force	0.0	0.1	0.1	0.3	-0.3	0.2	0.2	0.2	0.3
Bone: final moment	0.0	0.1	0.1	0.3	-0.3	0.2	0.2	0.3	0.2
Food consumed during 24 hour testing period	2.0	3.9	5.2	2.1	-1.3	2.3	2.1	-2.2	1.8
Glucose	1.0	1.6	2.9	1.7	-0.9	1.2	1.5	-0.5	1.4
Heart weight	0.6	1.0	1.3	-1.2	1.0	-1.1	-1.0	0.7	-1.0
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.4	0.7	-0.3	-0.2	-0.5	-0.5
Intermittent access intake day 1-15 change	0.1	0.4	0.8	-0.7	0.9	-0.5	-0.6	0.1	-0.9
Intermittent access intake escalation	0.2	0.8	1.2	-1.1	1.0	-0.8	-0.9	0.3	-1.1
Intermittent access intake escalation 2	0.0	0.1	0.2	0.1	-0.4	0.3	0.3	0.0	0.4
Intermitt. access day 1 inactive lever presses	0.3	3.4	4.3	2.0	-1.5	1.9	2.0	-1.3	2.1
Intermitt. access day 15 inactive lever presses	0.6	3.3	4.5	2.0	-2.1	2.0	1.9	-0.7	1.8
Intermitt. access escalation Index	0.2	0.5	0.9	-0.7	0.9	-0.9	-0.6	0.2	-0.6
Intermittent access day 1 total infusions	0.1	0.2	0.8	0.4	0.2	0.5	0.3	-0.9	0.3
Intermittent access day 15 total infusions	0.1	0.3	1.0	0.0	0.5	0.4	0.2	-1.0	-0.1
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.7	0.8	-0.3	1.2	0.9	-1.3	0.7
Intermittent access total infusions	0.2	0.3	1.1	0.2	0.1	0.7	0.2	-1.0	0.2
Intermittent access day 1 locomotion	0.2	0.4	0.7	0.7	-0.5	0.8	0.6	-0.7	0.6
Intermittent access day 15 total locomotion	0.0	0.1	0.2	-0.0	-0.1	0.5	-0.2	0.1	-0.2
Intermittent access total locomotion	0.1	0.1	0.2	-0.3	-0.1	-0.0	-0.4	0.4	-0.3
Intermittent access standard deviation	0.2	1.0	1.4	0.9	-0.6	1.2	1.1	-1.0	1.2
Left kidney weight	0.0	0.1	0.1	-0.3	0.1	0.3	-0.3	-0.0	-0.2
Right kidney weight	0.1	0.4	1.2	-0.1	-0.9	0.0	-0.3	1.1	0.1
Cocaine induced anxiety	0.2	0.4	0.6	-0.7	0.3	-0.6	-0.8	0.8	-0.5
Post-drug Anxiety	0.1	0.1	0.3	-0.2	-0.1	-0.5	-0.3	0.5	-0.0
Baseline Anxiety	0.9	1.6	4.6	1.1	0.2	1.0	1.3	-2.1	0.9
Tail length	0.2	1.2	2.0	1.0	-1.0	1.4	1.1	-0.9	1.0
Length with tail	0.3	1.5	2.4	1.2	-0.9	1.6	1.3	-1.1	1.1
Length without tail	0.2	1.0	1.8	1.2	-0.4	1.3	1.2	-0.9	0.8
Times rat made contact with spout	0.2	0.2	0.5	0.5	-0.7	0.1	0.3	0.3	0.5
Lifetime Intake	0.1	0.1	0.6	-0.2	0.3	0.1	-0.1	-0.8	0.0
Liver weight, left	0.5	0.9	3.0	0.8	-1.7	0.4	0.5	1.0	0.9
Liver weight, right	1.0	1.7	3.5	1.4	-1.9	1.6	1.2	-0.2	1.1
Locomotor activity	0.9	1.3	2.5	1.3	-0.1	1.6	1.2	-1.4	0.6
Locomotor testing distance	0.5	1.3	4.5	0.7	0.6	1.3	0.9	-2.1	0.3
Locomotor testing rearing	0.3	1.0	3.8	0.6	0.5	1.1	0.7	-2.0	0.4
Locomotion in novel chamber	0.0	0.1	0.2	0.4	-0.0	0.3	0.2	0.2	-0.2
Locomotion in novel chamber post-restriction	0.1	0.4	1.6	0.3	-1.3	0.1	0.4	0.7	0.5
Fecal boli incidents, locomotor time 1	0.3	0.9	1.9	-1.0	1.4	-0.9	-0.8	-0.2	-1.0
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.2	0.3	-0.4	-0.1	-0.0	0.1
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.9	-1.1	1.4	-1.3	-0.8	0.0	-0.7
Bouts of movement, locomotor time 1	1.0	1.3	1.9	-1.4	1.0	-1.1	-1.3	0.9	-1.1
Total resting periods, locomotor time 1	0.8	0.9	1.2	-1.1	0.7	-1.0	-1.1	0.9	-0.9
Rest time, locomotor task time 1	0.8	1.3	3.3	1.1	-0.2	1.3	1.2	-1.8	0.6
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.4	0.3	-0.3	-0.5	0.5	-0.3
Vertical activity count, locomotor time 1	0.1	0.9	3.4	-0.0	-1.1	-0.4	-0.5	1.8	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.4	1.2	-0.3	0.9	-0.2	0.0	-1.1	0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.1	-0.3	0.1	0.1	-0.0	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.0	0.2	0.1
Rest time, locomotor task time 2	0.8	1.3	3.6	1.0	0.1	1.2	1.2	-1.9	0.5
Distance moved, locomotor task time 2	1.0	1.3	2.1	-1.3	0.7	-1.0	-1.5	1.2	-1.2
Vertical activity count, locomotor time 2	0.3	0.6	2.4	-0.3	-0.7	-0.4	-0.6	1.5	-0.0
Light reinforcement 1	0.2	0.9	1.7	1.0	-1.3	1.0	0.7	-0.3	1.0
Light reinforcement 2	0.0	0.1	0.2	-0.4	0.0	-0.2	-0.5	0.1	-0.4
Bone: marrow area	1.2	3.0	4.0	2.0	-1.3	1.9	2.0	-1.5	1.7
Bone: maximum diameter	0.1	0.2	1.1	-0.0	-0.4	-0.4	-0.3	1.0	0.1
Bone: maximum force	0.2	0.4	0.6	0.8	-0.4	0.7	0.6	-0.3	0.6
Bone: maximum moment	0.2	0.4	0.7	0.9	-0.4	0.8	0.7	-0.3	0.6
Mean time between licks in bursts	0.9	5.4	7.1	-2.7	2.3	-2.2	-2.5	1.7	-2.5
Mean num. licks in bursts	0.3	0.7	1.7	0.9	-1.3	0.6	0.7	0.1	1.0
Cd content in liver	3.6	4.0	6.3	-2.1	2.5	-2.2	-2.1	0.9	-1.8
Co content in liver	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.3	0.1	-0.5
Cu content in liver	0.0	0.0	0.1	0.2	-0.3	0.2	0.1	0.0	0.1
Fe content in liver	0.8	1.0	1.9	-1.1	0.2	-0.9	-1.0	1.4	-0.9
K content in liver	0.4	0.4	1.3	0.3	-1.2	0.3	0.3	0.6	0.5
Mg content in liver	0.2	0.3	0.8	0.0	-0.9	-0.1	-0.1	0.9	0.1
Mn content in liver	0.1	0.1	0.3	-0.4	0.6	-0.3	-0.3	-0.1	-0.4
Na content in liver	0.6	0.7	1.7	0.7	-1.3	0.4	0.7	0.5	0.9
Rb content in liver	1.4	1.6	1.9	-1.3	1.0	-1.4	-1.4	1.2	-1.4
Se content in liver	0.1	0.1	0.3	-0.0	-0.3	0.1	-0.0	0.5	0.0
Sr content in liver	0.5	0.4	1.4	-0.0	1.0	0.2	0.1	-1.2	-0.2
Zn content in liver	0.2	0.2	0.3	-0.4	0.5	-0.4	-0.4	0.3	-0.5
Bone: minimum diameter	4.4	8.4	11.0	3.2	-3.3	3.2	3.0	-1.2	2.9
Time in familiar zone, hab. session 1	0.5	0.6	1.2	0.8	0.0	0.8	0.8	-1.1	0.5
Time in novel zone, hab. session 1	1.5	1.7	3.9	-1.3	-0.0	-1.4	-1.3	2.0	-1.0
Total zone transitions, hab. session 1	0.1	0.2	0.5	0.3	-0.7	0.4	0.3	-0.3	0.3
Total locomotion distance, hab. session 1	1.9	2.7	3.7	1.6	-1.4	1.9	1.7	-1.8	1.4
Locomotion velocity, hab. session 1	1.9	2.6	4.1	1.6	-1.0	1.8	1.7	-2.0	1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.2	0.4	-0.3	-0.2	-0.3	-0.1
Time in novel zone, hab. session 2	0.7	0.7	2.8	-0.5	-0.4	-0.6	-0.7	1.7	-0.5
Total zone transitions, hab. session 2	0.1	0.1	0.6	0.1	0.1	0.3	0.3	-0.8	0.1
Total locomotion distance, hab. session 2	0.8	1.0	1.9	0.9	-0.5	1.1	1.1	-1.4	0.9
Locomotion velocity, hab. session 2	0.9	1.2	2.4	1.0	-0.5	1.1	1.2	-1.6	1.0
Novel to familiar place preference ratio	0.4	0.5	1.9	-0.2	-0.9	-0.4	-0.4	1.4	-0.1
Novelty place preference	0.7	0.9	3.2	-0.5	-0.7	-0.8	-0.7	1.8	-0.4
Time in novel zone, NPP test	0.7	0.9	3.5	-0.3	-1.0	-0.7	-0.6	1.9	-0.2
Total zone transitions, NPP test	0.0	0.0	0.1	-0.0	-0.4	-0.1	0.1	0.1	0.1
Total locomotion distance, NPP test	0.4	0.6	1.7	0.5	-0.2	0.8	0.7	-1.3	0.5
Locomotion velocity, NPP test	0.2	0.4	1.5	0.2	0.1	0.5	0.5	-1.2	0.2
Intraocular pressure	0.5	0.9	1.1	-0.9	0.7	-1.0	-1.0	1.0	-0.9
Delta distance traveled before/after self-admin	3.8	4.2	5.4	2.3	-1.3	2.3	2.3	-1.9	2.0
Delta ambulatory time before/after self-admin	1.2	2.1	2.7	1.5	-0.8	1.6	1.6	-1.5	1.4
Parametrial fat weight	1.0	2.4	6.1	1.6	-2.5	1.2	1.3	0.7	1.3
Pavlov. Cond. lever latency	0.5	0.7	1.8	-0.8	1.4	-0.8	-0.7	-0.4	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.1	0.3	0.2	0.2	-0.5	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.2	0.5	-0.2
Pavlov. Cond. index score	0.1	0.2	0.5	0.4	-0.7	0.4	0.4	0.2	0.3
Pavlov. Cond. latency score	0.2	0.3	0.6	0.5	-0.8	0.6	0.5	0.1	0.4
Pavlov. Cond. lever contacts	0.4	0.5	1.3	0.8	-1.1	0.8	0.6	0.2	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	0.1	-1.0	-0.1	0.0	1.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	0.5	-0.8	0.5	0.5	0.1	0.4
Pavlov. Cond. response bias	0.2	0.2	0.4	0.5	-0.7	0.4	0.5	0.1	0.4
Pavlov. Cond. lever latency	0.4	0.5	2.4	0.1	-0.8	-0.2	-0.2	1.6	0.0
Pavlov. Cond. magazine entry latency	0.8	1.1	2.7	-1.1	1.6	-0.7	-0.8	-0.7	-0.9
Pavlov. Cond. change in total contacts	0.2	0.6	1.9	-0.4	1.1	0.1	-0.0	-1.4	-0.4
Pavlov. Cond. index score	0.5	0.8	2.3	-0.6	1.4	-0.1	-0.2	-1.5	-0.5
Pavlov. Cond. latency score	0.7	1.1	2.8	-0.8	1.7	-0.2	-0.4	-1.5	-0.7
Pavlov. Cond. lever contacts	0.3	0.5	2.4	0.2	0.4	0.5	0.4	-1.5	0.3
Pavlov. Cond. magazine entry number	1.4	1.8	4.8	1.4	-2.2	0.8	1.0	0.9	1.2
Pavlov. Cond. intertrial magazine entries	0.9	2.0	5.3	1.4	-2.3	1.0	1.2	0.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.1	-0.6	1.3	-0.1	-0.2	-1.4	-0.5
Pavlov. Cond. response bias	0.4	0.5	1.8	-0.4	1.0	-0.1	-0.1	-1.4	-0.3
Time in closed arm before self-admin	0.1	0.3	0.5	0.6	-0.7	0.7	0.4	0.0	0.2
Time in closed arm after self-admin	0.2	0.2	0.9	-0.3	1.0	-0.1	-0.2	-0.0	-0.3
Time in open arm before self-admin	0.5	0.6	1.7	0.0	1.1	0.4	0.1	-1.3	-0.7
Time in open arm after self-admin	0.7	0.8	2.4	0.8	-1.6	0.5	0.7	0.0	1.0
Bone: periosteal estimation	0.6	1.4	2.0	1.4	-1.1	1.3	1.3	-0.6	1.2
Bone: periosteal perimeter	0.3	0.5	0.9	1.0	-0.4	0.7	0.8	-0.5	0.9
Bone: post-yield work	0.0	0.1	0.2	0.2	-0.3	0.1	0.0	0.4	0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.1	0.3	0.5	-0.1	-0.7	-0.2
Progressive ratio test 1 breakpoint	0.1	0.2	0.7	-0.0	0.3	0.5	0.0	-0.8	-0.0
Progressive ratio test 1 inactive lever presses	1.3	3.3	4.1	1.8	-1.8	1.9	1.7	-1.5	2.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	0.3	0.2	-0.1	-0.2	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	0.3	0.2	-0.1	-0.3	0.0
Progressive ratio test 2 inactive lever presses	0.4	1.4	2.2	1.2	-1.0	1.2	1.2	-1.0	1.5
Incentive Sensitization - Responses	0.1	0.2	0.3	-0.4	0.5	-0.5	-0.4	0.3	-0.1
Incentive Sensitization - Breakpoint	0.1	0.2	0.3	-0.4	0.6	-0.4	-0.4	0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	0.7	-0.2	0.6	0.7	-1.0	0.9
Progressive ratio	0.0	0.1	0.4	0.2	0.0	0.3	0.2	-0.6	-0.1
Food seeking constrained by brief footshock	0.1	0.2	0.3	-0.4	0.2	-0.5	-0.5	0.1	-0.4
Seeking ratio, punishment vs. effort	0.1	0.3	0.7	0.2	-0.8	-0.1	0.1	0.6	0.6
Retroperitoneal fat weight	0.2	0.9	3.5	0.3	-1.2	-0.2	0.1	1.9	0.2
Reaction time number correct	0.0	0.1	0.1	0.4	0.3	0.1	0.4	-0.3	0.1
Reaction time mean minus median	0.2	1.0	1.8	-1.1	0.5	-1.1	-1.1	1.3	-0.7
Reaction time mean minus median AUC	0.2	1.6	4.4	-1.1	0.1	-1.5	-1.2	2.1	-0.7
Reaction time num false alarms	0.3	0.5	1.7	-0.0	-1.1	-0.0	-0.4	1.3	0.1
Reaction time num false alarms AUC	0.3	0.6	1.9	-0.4	-0.8	-0.4	-0.7	1.4	-0.2
Reaction time trials correct on left	0.0	0.1	0.1	0.4	0.3	0.1	0.4	-0.3	0.1
Reaction time trials on left	0.0	0.1	0.1	0.3	0.4	0.0	0.3	-0.3	-0.0
Reaction time mean	0.6	1.3	1.9	-1.4	0.7	-1.3	-1.3	1.2	-0.8
Reaction time mean AUC	0.5	1.2	1.8	-1.3	0.5	-1.3	-1.2	1.3	-0.8
Median of all reaction times	0.6	1.0	1.6	-1.2	0.7	-1.2	-1.1	1.0	-0.7
Reaction time omissions	0.8	1.3	2.0	-1.2	1.4	-1.0	-1.2	0.5	-1.3
Reaction time false alarm rate	0.5	0.7	2.1	-0.6	-0.8	-0.4	-0.8	1.4	-0.3
Reaction time premature initiation rate	0.2	0.3	1.0	0.2	-1.0	0.4	0.2	0.2	0.5
Reaction time premature initiations	0.1	0.3	0.9	0.4	-1.0	0.4	0.3	0.3	0.6
Std. dev. reaction times	0.3	1.0	1.4	-1.2	0.6	-1.0	-1.1	1.2	-0.8
Reaction time trials completed	0.0	0.1	0.1	0.3	0.4	0.0	0.3	-0.3	-0.0
Reaction time trials AUC	0.0	0.0	0.1	0.2	0.4	-0.1	0.2	-0.1	-0.1
Run reversals in cocaine runway, females	1.6	1.8	3.2	1.5	-1.3	1.8	1.3	-0.7	1.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.3	0.4	-0.2	-0.1	0.2	-0.5
Latency to leave start box in cocaine runway	1.5	2.0	3.3	1.5	-1.8	1.0	1.5	-0.4	1.8
Latency to leave start box in cocaine runway, F	3.1	3.9	6.5	2.2	-2.5	1.7	2.1	-0.4	2.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.1	0.1	-0.2	0.2	-0.4	0.5
Std. dev. time between licks in bursts	0.6	1.2	2.3	-1.2	1.5	-0.7	-1.1	0.0	-1.3
Total sessions with >9 infusions	1.0	1.3	1.9	-1.3	1.0	-1.1	-1.4	0.3	-1.2
Short access day 1 total inactive lever presses	0.9	1.9	3.0	1.3	-0.5	1.1	1.5	-1.7	1.7
Short access day 10 total inactive lever presses	0.3	2.2	2.9	1.5	-0.8	1.6	1.7	-1.4	1.7
Short access day 1 total infusions	0.1	0.2	0.5	0.4	-0.6	0.3	0.4	-0.4	0.7
Short access day 10 total infusions	0.2	0.3	1.2	-0.4	0.5	-0.1	-0.3	-1.1	-0.0
Short access total infusions	0.2	0.2	0.4	-0.6	0.5	-0.5	-0.5	-0.4	-0.3
Short access day 1 locomotion	0.1	0.2	0.4	-0.1	0.6	0.3	-0.1	-0.7	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.3	-0.0	-0.2
Short access total locomotion	0.2	0.3	0.4	-0.6	0.4	-0.4	-0.6	-0.1	-0.6
One hour access (0.3 mA shock)	0.2	0.3	0.5	0.5	-0.2	0.6	0.5	-0.7	0.6
Compulsive drug intake	0.4	0.6	1.1	0.8	-0.8	0.2	0.9	-0.6	1.0
One hour access (shock baseline)	0.0	0.1	0.2	-0.3	0.2	0.1	-0.4	0.2	-0.3
Social response proportion	1.2	1.5	3.2	1.3	-1.8	0.4	1.2	0.2	1.5
Social responses	0.7	0.9	1.6	1.3	-1.2	0.5	1.0	0.3	1.0
Social time	0.3	0.5	0.9	0.9	-1.0	0.2	0.7	0.1	0.8
Soleus weight	0.3	0.9	3.1	-0.3	1.8	0.1	-0.1	-1.4	-0.3
Bone: stiffness	0.5	0.8	2.1	0.9	-1.4	0.5	0.6	1.0	0.7
Tibialis anterior weight	3.6	12.3	15.2	-3.9	3.6	-3.6	-3.7	2.4	-3.5
Time to tail flick, vehicle, before self-admin	0.9	1.1	1.6	1.1	-1.0	1.3	1.2	-0.7	0.9
Time to tail flick, vehicle, after self-admin	1.3	2.7	4.4	1.8	-0.3	2.0	1.8	-2.1	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.0	0.2	0.4	0.0	-0.4	-0.4
Time to tail flick, test, after self-admin	1.1	1.1	1.7	1.2	-1.2	1.3	1.0	-0.2	1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.5	-0.2	0.4	0.3	-0.2	0.1
Delta time to tail flick, test, before/after SA	0.5	0.6	1.6	0.7	-1.3	0.4	0.6	0.6	0.9
Tibia length	0.1	0.2	0.5	0.3	-0.7	0.3	0.1	0.5	0.2
Ambulatory time before self-admin	0.0	0.0	0.1	0.3	-0.1	0.1	0.3	-0.3	0.1
Ambulatory time after self-admin	3.6	5.8	7.4	2.6	-1.7	2.4	2.7	-2.3	2.4
Bone: tissue strength	0.6	0.7	1.1	0.9	-0.9	1.0	0.8	-0.2	0.8
Total heroin consumption	0.7	0.9	1.4	1.2	-0.3	1.2	1.0	-1.0	0.5
Bone: trabecular number	0.1	0.2	0.4	-0.2	-0.4	-0.5	-0.3	0.7	0.0
Bone: trabecular spacing	0.5	0.7	2.5	-0.6	-0.3	-0.7	-0.7	1.6	-0.4
Bone: trabecular thickness	0.4	0.5	0.8	0.8	-0.2	0.7	0.7	-0.9	0.7
Bone: trabecular tissue density	0.8	1.4	2.1	-1.2	0.6	-1.3	-1.2	1.5	-1.2
Water consumed over 24 hours	0.9	1.8	2.5	1.6	-1.2	1.4	1.5	-0.9	1.3
Number of responses in last shaping day	0.2	0.2	0.4	-0.6	0.1	-0.5	-0.6	0.4	-0.2