Ugt2b10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ugt2b10	0.04	0.03	4.3e-04	0.02	0.02	0.02	0.02	8.8e-04	3.5e-03	3.1e-03	1.5e-03
2	Liver	intron excision ratio	chr14_21501126_21505929	0.17	0.1	2.2e-15	0.09	0.1	0.1	0.09	2.0e-10	3.2e-11	3.0e-11	7.0e-10
3	Liver	intron excision ratio	chr14_21501126_21503291	0.14	0.15	2.5e-07	0.04	0.04	0.04	0.01	1.1e-05	2.2e-05	1.5e-05	1.2e-02
4	Liver	intron excision ratio	chr14_21503408_21505929	0.1	0.07	3.1e-07	0.04	0.02	0.02	0.01	3.1e-05	2.5e-03	1.4e-03	7.7e-03
5	Liver	intron excision ratio	chr14_21506697_21508426	0.78	0.08	0.0e+00	0.29	0.24	0.27	0.29	7.1e-32	3.8e-26	2.3e-30	3.8e-32
6	Liver	intron excision ratio	chr14_21463596_21465266	0.5	0.16	0.0e+00	0.32	0.32	0.33	0.34	3.5e-36	4.3e-36	4.4e-38	2.2e-38

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.3	-0.3
Area under the delay curve	0.1	0.2	0.6	0.8	0.2	0.5	0.5	-0.1	0.2
BMI with tail	1.0	3.3	4.5	1.6	-2.0	-1.6	-1.6	2.1	-2.0
BMI without tail	0.4	2.3	3.0	1.7	-1.6	-1.2	-1.2	1.7	-1.5
Body weight	0.1	0.2	0.5	0.5	-0.7	-0.4	-0.4	0.5	-0.4
Weight adjusted by age	0.5	1.5	1.8	0.9	-1.3	-1.3	-1.3	1.2	-1.2
Bone surface	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.5	0.3	-0.3
Bone volume	0.2	0.3	0.4	-0.6	0.6	0.5	0.5	-0.5	0.5
Breakpoint value in progressive ratio session	0.2	0.3	0.4	-0.6	0.5	0.4	0.4	-0.6	0.6
Number of licking bursts	0.1	0.2	0.3	0.6	-0.5	-0.4	-0.4	0.5	-0.5
Context. condit. distance diff. score	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.5	-0.1	-0.1
Locomotion velocity, session 1	0.3	0.4	0.5	0.7	-0.6	-0.4	-0.4	0.7	-0.6
Locomotion distance, session 1	0.2	0.2	0.4	-0.5	0.4	0.4	0.4	-0.6	0.6
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1	-0.0	0.0
Locomotion distance, session 2	0.1	0.1	0.2	-0.3	0.3	0.3	0.3	-0.4	0.4
Locomotion velocity, session 3	0.7	0.8	0.9	-0.7	0.9	0.9	0.9	-0.9	0.9
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.2	0.2	0.2	-0.2	0.2
Stereotopy head waving bouts, day 3	0.4	0.5	0.8	0.9	-0.7	-0.5	-0.5	0.8	-0.7
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.3	-0.2	-0.0	-0.0	0.2	-0.2
Locomotion velocity, session 7	2.9	3.2	3.4	-1.7	1.8	1.8	1.8	-1.8	1.8
Locomotion distance, session 7	1.4	1.7	1.9	-1.3	1.4	1.2	1.2	-1.4	1.4
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	0.8	-0.7	-0.7	-0.7	0.7	-0.7
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.6	-0.5	-0.3	-0.3	0.6	-0.5
Locomotion velocity, session 8	0.1	0.1	0.2	0.2	-0.3	-0.4	-0.4	0.1	-0.2
Locomotion distance, session 8	0.1	0.2	0.4	-0.7	0.4	0.0	0.0	-0.6	0.5
Degree of sensitization distance	1.0	1.0	1.2	-1.1	1.0	0.9	0.9	-1.1	1.1
Degree of sensitization stereotypy	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.2	-0.2
Conditioned locomotion	0.4	0.5	0.6	0.6	-0.7	-0.8	-0.8	0.6	-0.6
Cocaine response after cond. corrected	0.6	0.9	1.0	-0.9	1.0	0.9	0.9	-1.0	1.0
Cocaine response after cond. not corrected	0.4	0.6	0.7	-0.7	0.8	0.7	0.7	-0.9	0.8
Cocaine response before conditioning	0.4	0.5	0.6	0.7	-0.7	-0.8	-0.8	0.6	-0.7
Saline control response	0.5	0.7	1.2	-0.7	0.7	0.6	0.6	-1.1	1.1
Bone: connectivity density	0.2	0.3	0.4	0.6	-0.6	-0.5	-0.5	0.5	-0.5
Bone: cortical apparent density	0.3	0.5	1.1	-0.4	0.6	1.0	1.0	-0.2	0.4
Bone: cortical area	0.2	0.3	0.3	-0.5	0.5	0.6	0.6	-0.5	0.5
Bone: cortical porosity	1.9	2.1	2.4	1.4	-1.4	-1.5	-1.5	1.3	-1.4
Bone: cortical porosity	3.9	4.2	4.5	2.1	-2.1	-2.1	-2.1	2.0	-2.0
Bone: cortical thickness	0.3	0.5	0.6	0.7	-0.8	-0.7	-0.7	0.8	-0.7
Bone: cortical thickness	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.0	-0.3	0.2
Bone: cortical tissue density	0.2	0.4	0.9	-0.3	0.6	1.0	1.0	-0.1	0.3
Condit. Reinf. active minus inactive responses	0.7	0.7	0.9	1.0	-0.9	-0.8	-0.8	0.9	-0.8
Condit. Reinf. active-inactive response ratio	4.0	4.3	4.5	2.1	-2.1	-2.1	-2.1	2.0	-2.0
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	0.2	0.2	0.2	-0.1	0.2
Condit. Reinf. inactive responses	2.4	3.1	3.4	-1.8	1.8	1.8	1.8	-1.7	1.7
Incentive salience index mean	0.1	0.1	0.1	0.4	-0.3	-0.2	-0.2	0.3	-0.2
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.2	0.4	0.5	0.5	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.3	0.5	0.6	0.6	-0.7	0.7
Condit. Reinf. active responses	0.1	0.2	0.3	-0.2	0.4	0.4	0.4	-0.6	0.6
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.4	0.4	0.2	0.2	-0.6	0.5
Condit. Reinf. lever presses	0.4	0.6	1.0	-0.9	0.8	0.6	0.6	-1.0	0.9
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	-0.3	0.4	0.4	0.4	-0.6	0.6
Conditioned reinforcement - actives	0.1	0.2	0.4	0.1	-0.5	-0.7	-0.7	0.2	-0.3
Conditioned reinforcement - inactives	0.4	1.0	1.4	-1.2	1.0	0.9	0.9	-1.0	1.0
Conditioned locomotion	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.1	-0.2	0.2
Patch foraging indifference point 0 sec	0.2	0.6	0.7	-0.6	0.8	0.8	0.8	-0.7	0.8
Patch foraging indifference point AUC	2.6	6.1	7.3	-2.3	2.4	2.7	2.7	-2.3	2.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.2	0.5	-0.0	0.1	0.1	0.0	0.1
Delay disc. indifference point, 16s delay	0.5	0.7	3.2	1.8	-0.6	-0.0	-0.0	0.7	-0.6
Delay disc. indifference point, 2s delay	3.5	3.9	4.3	-2.0	2.1	1.9	1.9	-2.0	2.0
Delay disc. indifference point, 24s delay	0.1	0.2	1.0	1.0	-0.2	-0.1	-0.1	0.3	-0.3
Delay disc. indifference point, 4s delay	0.6	0.6	1.0	-0.1	0.8	1.0	1.0	-0.7	0.8
Delay disc. indifference point, 8s delay	0.8	1.3	3.7	1.9	-1.0	-0.7	-0.7	1.1	-1.0
Indifference point function ln k	1.0	3.1	3.3	1.8	-1.7	-1.8	-1.8	1.6	-1.7
Indifference point function log k	1.0	3.1	3.3	1.8	-1.7	-1.8	-1.8	1.6	-1.7
Patch foraging total patch changes 0 sec	0.3	0.8	0.9	-0.7	0.9	1.0	1.0	-0.9	0.9
Patch foraging total patch changes 12 sec	1.5	2.0	3.1	-1.7	1.3	1.6	1.6	-1.1	1.1
Patch foraging total patch changes 18 sec	0.3	0.8	1.0	-0.4	0.8	1.0	1.0	-0.9	0.9
Patch foraging total patch changes 24 sec	0.6	2.0	2.5	-1.6	1.4	1.5	1.5	-1.3	1.3
Patch foraging total patch changes 6 sec	2.3	3.9	4.5	-1.8	2.0	2.1	2.1	-1.8	1.9
Patch foraging time to switch 0 sec	1.5	5.7	6.0	2.1	-2.4	-2.4	-2.4	2.4	-2.4
Patch foraging water rate 0 sec	0.8	2.9	3.4	-1.6	1.7	1.8	1.8	-1.6	1.6
Patch foraging water rate 12 sec	0.0	0.1	0.3	-0.4	0.4	0.2	0.2	-0.5	0.4
Patch foraging water rate 18 sec	0.8	1.8	3.0	-1.7	1.4	1.1	1.1	-1.4	1.3
Patch foraging water rate 24 sec	0.7	1.0	1.6	-1.3	1.2	0.7	0.7	-1.1	1.0
Patch foraging water rate 6 sec	0.5	0.8	1.0	-0.4	0.9	0.9	0.9	-1.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	1.6	-1.3	0.9	0.6	0.6	-1.0	1.0
Distance traveled before self-admin	0.0	0.0	0.2	0.5	-0.1	-0.2	-0.2	-0.1	0.0
Distance traveled after self-admin	1.9	3.3	4.9	-1.7	1.9	1.4	1.4	-2.2	2.0
Extensor digitorum longus weight	10.8	43.0	44.4	6.6	-6.6	-6.4	-6.4	6.7	-6.6
Bone: elastic displacement	0.5	0.6	0.8	0.7	-0.8	-0.9	-0.9	0.6	-0.7
Bone: elastic work	0.4	0.5	0.9	0.6	-0.7	-0.9	-0.9	0.3	-0.4
Bone: endosteal estimation	1.0	2.3	2.8	-1.7	1.5	1.3	1.3	-1.7	1.6
Bone: endosteal perimeter	0.1	0.3	0.4	-0.6	0.5	0.4	0.4	-0.6	0.5
Epididymis fat weight	0.1	0.4	1.0	-0.3	0.4	1.0	1.0	-0.1	0.3
Delta time in closed arm before/after self-admin	0.8	0.8	1.1	0.7	-1.0	-0.8	-0.8	1.0	-1.0
Delta time in open arm before/after self-admin	0.5	0.6	0.8	-0.3	0.9	0.9	0.9	-0.8	0.9
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	-0.1	-0.1	-0.3	-0.3	0.3	-0.3
Delay discount exponential model param	0.2	0.2	0.4	-0.5	-0.4	-0.6	-0.6	0.3	-0.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.3	-0.3	-0.5	-0.5	0.1	-0.2
Active lever presses in extinction session 6	0.8	0.8	1.2	-1.1	0.9	0.8	0.8	-0.9	0.9
Bone: final force	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	-0.1	0.1
Bone: final moment	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	-0.1	0.1
Food consumed during 24 hour testing period	1.1	2.2	2.8	-1.7	1.6	1.2	1.2	-1.6	1.5
Glucose	0.7	1.1	1.5	-1.2	1.2	1.0	1.0	-1.0	0.9
Heart weight	0.8	1.2	1.6	1.2	-1.1	-0.9	-0.9	1.2	-1.2
Delay discount hyperbolic model param	0.3	0.4	0.6	-0.1	-0.7	-0.8	-0.8	0.5	-0.6
Intermittent access intake day 1-15 change	0.1	0.7	0.9	1.0	-0.9	-0.9	-0.9	0.7	-0.7
Intermittent access intake escalation	0.2	1.1	1.6	1.3	-1.1	-1.0	-1.0	0.9	-0.9
Intermittent access intake escalation 2	0.1	0.2	0.3	0.1	0.4	0.4	0.4	-0.5	0.5
Intermitt. access day 1 inactive lever presses	0.3	3.5	4.1	-1.8	2.0	1.8	1.8	-1.9	1.8
Intermitt. access day 15 inactive lever presses	1.0	5.2	5.5	-2.4	2.3	2.3	2.3	-2.2	2.2
Intermitt. access escalation Index	0.2	0.7	0.8	0.6	-0.9	-0.9	-0.9	0.8	-0.8
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	0.1	-0.2	-0.2	0.0	-0.1
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.2	-0.2	-0.5	-0.5	0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.5	-0.4	0.6	0.3	0.3	-0.7	0.7
Intermittent access total infusions	0.0	0.0	0.1	0.0	0.1	-0.3	-0.3	-0.2	0.2
Intermittent access day 1 locomotion	0.1	0.3	0.5	-0.7	0.5	0.4	0.4	-0.5	0.5
Intermittent access day 15 total locomotion	0.0	0.1	0.7	-0.8	-0.1	-0.2	-0.2	-0.2	0.2
Intermittent access total locomotion	0.0	0.0	0.1	0.0	-0.2	-0.3	-0.3	0.1	-0.1
Intermittent access standard deviation	0.2	0.8	1.0	-0.7	1.0	1.0	1.0	-0.9	0.9
Left kidney weight	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1
Right kidney weight	0.1	0.5	0.8	-0.7	0.7	0.9	0.9	-0.4	0.5
Cocaine induced anxiety	0.0	0.1	0.2	0.2	-0.4	-0.2	-0.2	0.4	-0.3
Post-drug Anxiety	0.0	0.0	0.1	0.2	0.1	0.2	0.2	0.0	0.1
Baseline Anxiety	0.0	0.1	0.2	0.1	0.5	-0.0	-0.0	-0.3	0.2
Tail length	0.2	1.1	1.5	-0.9	1.0	1.0	1.0	-1.2	1.2
Length with tail	0.2	0.8	1.3	-0.8	0.8	0.7	0.7	-1.1	1.1
Length without tail	0.1	0.3	0.8	-0.9	0.5	0.3	0.3	-0.6	0.5
Times rat made contact with spout	0.2	0.3	0.4	-0.4	0.5	0.5	0.5	-0.6	0.6
Lifetime Intake	0.1	0.2	0.3	0.4	-0.3	-0.5	-0.5	0.2	-0.2
Liver weight, left	1.2	2.0	2.5	-1.1	1.4	1.6	1.6	-1.4	1.5
Liver weight, right	1.7	3.0	4.0	-2.0	1.7	1.6	1.6	-1.6	1.7
Locomotor activity	0.1	0.1	0.3	-0.4	0.2	-0.2	-0.2	-0.5	0.4
Locomotor testing distance	0.1	0.3	0.7	0.3	-0.4	-0.8	-0.8	0.0	-0.2
Locomotor testing rearing	0.1	0.3	0.6	0.5	-0.4	-0.8	-0.8	-0.0	-0.1
Locomotion in novel chamber	0.0	0.0	0.2	0.4	-0.2	-0.0	-0.0	0.1	-0.1
Locomotion in novel chamber post-restriction	0.4	1.1	1.6	-0.7	1.0	1.3	1.3	-0.9	1.0
Fecal boli incidents, locomotor time 1	0.8	2.1	3.2	1.8	-1.3	-1.4	-1.4	1.3	-1.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	-0.2	-0.1	-0.1	0.3	-0.3
Time >=10cm from walls, locomotor time 1	1.2	1.5	2.2	1.5	-1.3	-1.1	-1.1	1.2	-1.2
Bouts of movement, locomotor time 1	0.6	0.7	1.0	0.8	-0.9	-0.7	-0.7	1.0	-1.0
Total resting periods, locomotor time 1	0.3	0.4	0.7	0.4	-0.7	-0.5	-0.5	0.8	-0.8
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.6	0.4	0.1	0.1	-0.6	0.5
Distance moved, locomotor task time 1	0.0	0.1	0.2	0.3	-0.3	-0.3	-0.3	0.4	-0.4
Vertical activity count, locomotor time 1	0.1	0.5	0.8	-0.2	0.7	0.9	0.9	-0.5	0.7
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.5	1.2	-0.6	-0.8	-0.8	0.5	-0.6
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.3	0.5	0.4	0.4	-0.3	0.3
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.4	0.3	0.4	0.4	-0.2	0.2
Rest time, locomotor task time 2	0.1	0.1	0.5	-0.7	0.2	-0.0	-0.0	-0.4	0.3
Distance moved, locomotor task time 2	0.7	0.9	1.1	0.8	-1.0	-1.0	-1.0	1.1	-1.0
Vertical activity count, locomotor time 2	0.1	0.2	0.4	-0.4	0.4	0.6	0.6	-0.2	0.4
Light reinforcement 1	0.3	1.3	1.4	-1.1	1.1	1.1	1.1	-1.2	1.2
Light reinforcement 2	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.0	-0.0
Bone: marrow area	0.9	2.1	2.6	-1.6	1.5	1.2	1.2	-1.6	1.5
Bone: maximum diameter	0.0	0.0	0.0	-0.0	0.0	0.2	0.2	0.0	0.1
Bone: maximum force	0.0	0.1	0.2	-0.4	0.2	0.1	0.1	-0.3	0.3
Bone: maximum moment	0.1	0.1	0.2	-0.5	0.3	0.2	0.2	-0.4	0.4
Mean time between licks in bursts	1.0	6.0	6.5	2.5	-2.6	-2.4	-2.4	2.4	-2.3
Mean num. licks in bursts	0.5	1.4	1.6	-1.2	1.2	1.1	1.1	-1.2	1.3
Cd content in liver	4.9	5.4	6.2	2.2	-2.3	-2.2	-2.2	2.5	-2.5
Co content in liver	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.3	0.4	-0.4
Cu content in liver	0.1	0.1	0.2	-0.5	0.3	0.3	0.3	-0.3	0.3
Fe content in liver	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.2	0.5	-0.4
K content in liver	1.1	1.0	1.2	-0.8	1.0	1.1	1.1	-1.1	1.1
Mg content in liver	0.4	0.5	0.6	-0.4	0.6	0.8	0.8	-0.7	0.8
Mn content in liver	0.2	0.3	0.4	0.6	-0.5	-0.5	-0.5	0.5	-0.5
Na content in liver	1.3	1.4	1.8	-0.9	1.2	1.4	1.4	-1.1	1.2
Rb content in liver	1.0	1.2	1.6	1.0	-1.1	-0.9	-0.9	1.3	-1.2
Se content in liver	0.2	0.2	0.3	-0.4	0.5	0.5	0.5	-0.2	0.2
Sr content in liver	0.7	0.6	0.9	0.6	-0.7	-1.0	-1.0	0.7	-0.8
Zn content in liver	0.1	0.1	0.3	-0.0	-0.3	-0.3	-0.3	0.5	-0.5
Bone: minimum diameter	4.6	8.9	11.1	-2.9	2.8	2.7	2.7	-3.3	3.3
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.0	-0.3	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.4	0.6	-0.4	-0.1	-0.1	0.4	-0.3
Total zone transitions, hab. session 1	0.3	0.4	0.4	-0.6	0.6	0.6	0.6	-0.6	0.6
Total locomotion distance, hab. session 1	1.6	2.3	2.7	-1.6	1.5	1.3	1.3	-1.6	1.6
Locomotion velocity, hab. session 1	1.2	1.6	2.1	-1.4	1.3	1.1	1.1	-1.4	1.3
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.0	-0.1	-0.2	-0.2	0.2	-0.2
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.0	-0.0	0.3	0.3	0.1	0.0
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.2	-0.0	-0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.9	0.6	0.4	0.4	-0.7	0.7
Locomotion velocity, hab. session 2	0.3	0.5	0.9	-0.9	0.7	0.4	0.4	-0.8	0.7
Novel to familiar place preference ratio	0.3	0.4	0.6	-0.3	0.5	0.7	0.7	-0.5	0.6
Novelty place preference	0.1	0.2	0.3	-0.0	0.2	0.6	0.6	-0.3	0.4
Time in novel zone, NPP test	0.3	0.4	0.7	-0.3	0.5	0.9	0.9	-0.5	0.7
Total zone transitions, NPP test	0.0	0.1	0.1	-0.2	0.2	0.3	0.3	-0.3	0.3
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.4	0.4	0.2	0.2	-0.5	0.4
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.2	-0.1	0.0
Intraocular pressure	0.5	0.8	1.3	1.2	-0.9	-0.8	-0.8	0.9	-0.8
Delta distance traveled before/after self-admin	2.8	3.1	5.3	-2.3	1.8	1.4	1.4	-1.8	1.7
Delta ambulatory time before/after self-admin	0.9	1.5	3.1	-1.8	1.2	0.9	0.9	-1.3	1.2
Parametrial fat weight	2.4	5.7	7.0	-2.5	2.3	2.6	2.6	-2.0	2.1
Pavlov. Cond. lever latency	1.1	1.4	1.5	1.1	-1.2	-1.2	-1.2	1.1	-1.2
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.1	0.2	0.2	-0.1	0.1
Pavlov. Cond. index score	0.2	0.3	0.3	-0.6	0.5	0.6	0.6	-0.5	0.6
Pavlov. Cond. latency score	0.3	0.4	0.4	-0.7	0.6	0.6	0.6	-0.6	0.6
Pavlov. Cond. lever contacts	0.7	0.9	0.9	-0.9	0.9	1.0	1.0	-0.9	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.1	-0.6	0.8	1.0	1.0	-0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.7	0.6	0.7	0.7	-0.6	0.7
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	-0.6	0.6
Pavlov. Cond. lever latency	0.5	0.7	1.2	-0.7	0.8	1.1	1.1	-0.4	0.5
Pavlov. Cond. magazine entry latency	1.7	2.3	2.8	1.5	-1.6	-1.7	-1.7	1.4	-1.4
Pavlov. Cond. change in total contacts	0.5	1.2	1.8	1.0	-1.1	-1.4	-1.4	0.7	-0.8
Pavlov. Cond. index score	1.1	1.7	2.5	1.2	-1.3	-1.6	-1.6	0.9	-1.1
Pavlov. Cond. latency score	1.6	2.6	3.6	1.5	-1.6	-1.9	-1.9	1.2	-1.4
Pavlov. Cond. lever contacts	0.1	0.2	0.4	0.3	-0.4	-0.7	-0.7	0.0	-0.1
Pavlov. Cond. magazine entry number	3.3	4.3	5.3	-2.0	2.1	2.3	2.3	-1.8	1.9
Pavlov. Cond. intertrial magazine entries	1.8	3.9	4.4	-1.7	2.0	2.1	2.1	-2.0	2.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.6	2.4	1.2	-1.3	-1.5	-1.5	0.9	-1.0
Pavlov. Cond. response bias	0.7	1.0	1.6	0.9	-1.0	-1.3	-1.3	0.7	-0.8
Time in closed arm before self-admin	0.3	0.5	0.7	-0.8	0.8	0.7	0.7	-0.5	0.5
Time in closed arm after self-admin	0.3	0.3	0.6	-0.1	-0.5	-0.4	-0.4	0.8	-0.8
Time in open arm before self-admin	0.9	1.0	1.7	0.7	-0.9	-1.3	-1.3	0.8	-0.9
Time in open arm after self-admin	1.4	1.5	1.9	-0.3	1.3	1.3	1.3	-1.3	1.4
Bone: periosteal estimation	0.5	1.1	1.3	-1.1	1.0	0.9	0.9	-1.1	1.1
Bone: periosteal perimeter	0.1	0.2	0.5	-0.7	0.5	0.4	0.4	-0.4	0.4
Bone: post-yield work	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	-0.2	0.2
Progressive ratio test 1 active lever presses	0.1	0.3	0.5	0.4	-0.4	-0.7	-0.7	0.2	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	0.4	-0.3	-0.7	-0.7	0.2	-0.2
Progressive ratio test 1 inactive lever presses	1.2	3.1	3.9	-1.4	2.0	1.7	1.7	-1.9	1.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.3	-0.3	-0.5	-0.5	0.1	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.5	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.4	1.2	1.6	-1.0	1.2	0.9	0.9	-1.3	1.2
Incentive Sensitization - Responses	0.1	0.3	0.4	0.6	-0.6	-0.6	-0.6	0.4	-0.3
Incentive Sensitization - Breakpoint	0.1	0.3	0.4	0.6	-0.6	-0.7	-0.7	0.4	-0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.4	0.1	0.0	0.0	-0.5	0.5
Progressive ratio	0.0	0.1	0.4	-0.7	-0.1	-0.3	-0.3	0.1	-0.2
Food seeking constrained by brief footshock	0.1	0.1	0.1	-0.0	-0.3	-0.3	-0.3	0.3	-0.3
Seeking ratio, punishment vs. effort	0.3	0.7	1.1	-0.1	0.8	1.0	1.0	-0.8	0.9
Retroperitoneal fat weight	0.3	1.3	2.2	-1.3	1.0	1.5	1.5	-0.6	0.8
Reaction time number correct	0.0	0.1	0.2	0.4	-0.4	-0.5	-0.5	0.2	-0.3
Reaction time mean minus median	0.0	0.3	0.8	0.9	-0.4	-0.2	-0.2	0.6	-0.5
Reaction time mean minus median AUC	0.0	0.1	0.3	0.5	-0.2	0.1	0.1	0.5	-0.4
Reaction time num false alarms	0.3	0.5	0.9	-0.4	0.7	1.0	1.0	-0.5	0.6
Reaction time num false alarms AUC	0.1	0.2	0.5	-0.2	0.4	0.7	0.7	-0.3	0.4
Reaction time trials correct on left	0.0	0.1	0.2	0.4	-0.4	-0.5	-0.5	0.2	-0.3
Reaction time trials on left	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.5	0.3	-0.4
Reaction time mean	0.2	0.5	1.4	1.2	-0.6	-0.4	-0.4	0.7	-0.7
Reaction time mean AUC	0.2	0.4	1.1	1.1	-0.5	-0.3	-0.3	0.6	-0.5
Median of all reaction times	0.3	0.5	1.3	1.1	-0.6	-0.4	-0.4	0.6	-0.6
Reaction time omissions	0.8	1.3	1.9	0.9	-1.1	-1.1	-1.1	1.4	-1.4
Reaction time false alarm rate	0.2	0.3	0.6	-0.4	0.5	0.8	0.8	-0.3	0.4
Reaction time premature initiation rate	0.4	0.6	0.9	-0.3	0.8	0.8	0.8	-0.9	0.9
Reaction time premature initiations	0.2	0.5	0.8	-0.1	0.7	0.7	0.7	-0.8	0.9
Std. dev. reaction times	0.1	0.4	1.2	1.1	-0.5	-0.3	-0.3	0.7	-0.6
Reaction time trials completed	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.5	0.3	-0.4
Reaction time trials AUC	0.1	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.4	-0.4
Run reversals in cocaine runway, females	2.2	2.5	4.8	-2.2	1.5	1.4	1.4	-1.4	1.4
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.1	-0.4	-0.4	-0.4	0.6	-0.6
Latency to leave start box in cocaine runway	2.4	3.3	3.6	-1.9	1.9	1.8	1.8	-1.8	1.8
Latency to leave start box in cocaine runway, F	5.1	6.4	6.6	-2.6	2.5	2.5	2.5	-2.5	2.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.3	0.2	0.1	0.1	-0.1	0.1
Std. dev. time between licks in bursts	1.4	2.7	3.3	1.6	-1.7	-1.8	-1.8	1.4	-1.4
Total sessions with >9 infusions	1.5	1.8	2.0	1.3	-1.3	-1.4	-1.4	1.3	-1.3
Short access day 1 total inactive lever presses	0.4	0.8	1.2	-0.8	1.1	0.8	0.8	-1.0	0.9
Short access day 10 total inactive lever presses	0.3	2.1	3.4	-1.8	1.4	1.4	1.4	-1.4	1.3
Short access day 1 total infusions	0.1	0.2	0.4	-0.7	0.4	0.4	0.4	-0.5	0.5
Short access day 10 total infusions	0.3	0.5	1.0	0.7	-0.6	-1.0	-1.0	0.3	-0.4
Short access total infusions	0.5	0.7	1.1	1.1	-0.7	-0.9	-0.9	0.6	-0.6
Short access day 1 locomotion	0.2	0.3	0.5	-0.5	-0.5	-0.7	-0.7	0.5	-0.5
Short access day 10 total locomotion	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.2	0.2	-0.2
Short access total locomotion	0.2	0.3	0.4	0.3	-0.6	-0.6	-0.6	0.5	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.5	0.3	0.2	0.2	-0.4	0.3
Compulsive drug intake	0.5	0.7	0.9	-0.9	0.7	0.9	0.9	-0.8	0.8
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	-0.2	-0.3	-0.3	0.2	-0.2
Social response proportion	2.4	3.1	4.1	-2.0	1.8	1.8	1.8	-1.6	1.6
Social responses	0.9	1.2	2.1	-1.4	1.1	1.0	1.0	-0.9	1.0
Social time	0.6	1.0	1.1	-1.0	1.0	1.0	1.0	-0.9	0.9
Soleus weight	0.6	1.7	2.2	0.9	-1.3	-1.5	-1.5	1.3	-1.4
Bone: stiffness	0.7	1.3	1.4	-1.1	1.1	1.2	1.2	-1.0	1.1
Tibialis anterior weight	4.1	14.2	16.4	4.0	-3.9	-3.6	-3.6	3.8	-3.7
Time to tail flick, vehicle, before self-admin	1.2	1.5	2.2	-1.5	1.1	1.1	1.1	-1.2	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	-0.1	0.7	0.3	0.3	-0.7	0.5
Time to tail flick, test, before self-admin	0.0	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.2	-0.2
Time to tail flick, test, after self-admin	1.6	1.6	2.0	-1.1	1.4	1.4	1.4	-1.2	1.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.2	0.5	0.1	-0.0	-0.0	-0.1	0.0
Delta time to tail flick, test, before/after SA	1.3	1.6	2.3	-1.1	1.2	1.5	1.5	-1.1	1.1
Tibia length	0.1	0.3	0.4	-0.6	0.5	0.6	0.6	-0.5	0.5
Ambulatory time before self-admin	0.0	0.0	0.2	0.4	-0.1	-0.2	-0.2	-0.1	0.1
Ambulatory time after self-admin	1.9	3.1	4.5	-1.7	1.8	1.4	1.4	-2.1	2.0
Bone: tissue strength	0.7	0.7	0.9	-0.9	0.8	0.8	0.8	-0.8	0.8
Total heroin consumption	0.3	0.3	1.0	-1.0	0.5	0.2	0.2	-0.6	0.5
Bone: trabecular number	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.1	0.2
Bone: trabecular spacing	0.1	0.1	0.2	-0.3	0.2	0.4	0.4	0.0	0.0
Bone: trabecular thickness	0.1	0.1	0.4	-0.6	0.4	0.3	0.3	-0.3	0.2
Bone: trabecular tissue density	0.4	0.6	1.0	0.8	-0.8	-0.6	-0.6	1.0	-0.9
Water consumed over 24 hours	0.8	1.6	1.8	-1.3	1.3	1.2	1.2	-1.3	1.3
Number of responses in last shaping day	0.1	0.1	0.2	-0.0	-0.4	-0.5	-0.5	0.3	-0.2