Hub : Genes

Ugt2b-ps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ugt2b-ps1	0.34	0.14	0.0e+00	0.2	0.22	0.25	0.26	2.3e-21	2.4e-24	3.2e-27	3.8e-29
2	Liver	intron excision ratio	chr14_20989813_20990844	0.18	0.11	2.8e-16	0.13	0.12	0.13	0.14	8.4e-14	5.2e-13	2.2e-14	1.8e-15
3	Liver	intron excision ratio	chr14_21126776_21134214	0.67	0.11	0.0e+00	0.5	0.42	0.51	0.51	3.1e-63	1.2e-50	2.8e-65	1.4e-65
4	Liver	intron excision ratio	chr14_21076424_21087889	0.74	0.07	0.0e+00	0.35	0.26	0.38	0.36	2.3e-40	2.5e-28	2.3e-44	3.7e-42

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.1
Area under the delay curve	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.0
BMI with tail	2.2	7.6	9.2	3.0	-2.6	-3.0	-2.4
BMI without tail	1.2	6.2	7.9	2.6	-2.3	-2.8	-2.2
Body weight	0.3	1.4	2.1	1.3	-1.0	-1.4	-1.1
Weight adjusted by age	0.2	0.7	1.1	0.5	-1.1	-0.8	-0.8
Bone surface	0.0	0.1	0.1	-0.4	0.2	0.3	0.1
Bone volume	0.2	0.5	0.5	-0.7	0.7	0.7	0.7
Breakpoint value in progressive ratio session	0.1	0.2	0.5	-0.3	0.4	0.4	0.7
Number of licking bursts	0.0	0.1	0.2	0.3	-0.4	-0.3	-0.4
Context. condit. distance diff. score	1.1	1.3	2.7	-1.6	0.9	1.2	0.5
Locomotion velocity, session 1	1.4	1.6	2.4	1.5	-1.1	-1.3	-1.0
Locomotion distance, session 1	0.3	0.3	0.4	-0.6	0.6	0.6	0.4
Locomotion velocity, session 2	0.0	0.1	0.1	-0.3	0.2	0.2	0.1
Locomotion distance, session 2	0.1	0.1	0.2	-0.4	0.4	0.4	0.3
Locomotion velocity, session 3	0.7	0.8	1.0	-0.8	1.0	0.9	1.0
Locomotion distance, session 3	0.1	0.1	0.1	-0.4	0.3	0.3	0.3
Stereotopy head waving bouts, day 3	0.9	1.1	1.3	1.1	-1.1	-1.0	-0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.6	-0.5	-0.4	-0.3
Locomotion velocity, session 7	1.9	2.1	2.5	-1.3	1.6	1.2	1.6
Locomotion distance, session 7	1.6	2.1	2.4	-1.6	1.5	1.4	1.3
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.6	-0.7	-0.4	-0.4
Stereotopy head waving duration, day 7	0.5	0.7	1.2	1.1	-0.9	-0.7	-0.4
Locomotion velocity, session 8	0.1	0.1	0.2	-0.5	0.2	0.3	0.0
Locomotion distance, session 8	1.6	2.3	4.0	-2.0	1.3	1.6	0.9
Degree of sensitization distance	1.2	1.3	1.6	-1.3	1.2	1.1	1.0
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	-0.1	0.2	0.2
Conditioned locomotion	0.2	0.2	0.4	0.3	-0.4	-0.4	-0.6
Cocaine response after cond. corrected	0.6	0.9	1.0	-0.8	1.0	1.0	1.0
Cocaine response after cond. not corrected	0.7	1.0	1.0	-1.0	1.0	1.0	0.9
Cocaine response before conditioning	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.4
Saline control response	0.7	0.9	1.2	-1.1	1.0	0.8	0.9
Bone: connectivity density	0.2	0.4	0.5	0.7	-0.5	-0.7	-0.6
Bone: cortical apparent density	0.4	0.6	1.6	1.3	-0.4	-0.9	-0.2
Bone: cortical area	0.1	0.2	0.4	-0.4	0.4	0.4	0.6
Bone: cortical porosity	0.8	0.8	1.0	0.7	-1.0	-0.9	-1.0
Bone: cortical porosity	2.5	2.8	3.2	1.4	-1.8	-1.7	-1.7
Bone: cortical thickness	0.3	0.5	0.7	0.7	-0.8	-0.8	-0.6
Bone: cortical thickness	0.5	0.6	0.9	-0.9	0.7	0.8	0.7
Bone: cortical tissue density	0.5	0.7	1.8	1.3	-0.5	-0.9	-0.2
Condit. Reinf. active minus inactive responses	1.0	1.1	1.3	1.0	-1.0	-1.1	-1.1
Condit. Reinf. active-inactive response ratio	2.8	3.0	3.6	1.4	-1.9	-1.8	-1.8
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	0.0	-0.1	-0.1
Condit. Reinf. inactive responses	1.6	2.0	2.7	-1.1	1.6	1.5	1.4
Incentive salience index mean	0.1	0.2	0.2	0.3	-0.4	-0.4	-0.4
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.0	0.0	0.2	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.1	0.4	0.3	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.2	0.5	0.4	0.5
Condit. Reinf. active responses	0.2	0.2	0.3	-0.4	0.6	0.5	0.3
Condit. Reinf. inactive responses	0.4	0.6	1.0	-1.0	0.8	0.8	0.4
Condit. Reinf. lever presses	1.2	1.8	2.0	-1.4	1.3	1.4	1.2
Condit. Reinf. lever reinforcers received	0.4	0.5	0.6	-0.7	0.8	0.7	0.5
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.2
Conditioned reinforcement - inactives	0.3	0.9	1.5	-0.7	0.9	0.7	1.2
Conditioned locomotion	0.1	0.1	0.2	-0.4	0.3	0.2	-0.3
Patch foraging indifference point 0 sec	0.2	0.4	0.6	-0.5	0.8	0.6	0.7
Patch foraging indifference point AUC	1.3	3.0	3.8	-1.4	1.9	1.6	1.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.1
Delay disc. indifference point, 16s delay	1.0	1.4	1.9	1.4	-1.1	-1.3	-0.9
Delay disc. indifference point, 2s delay	2.7	3.0	3.3	-1.7	1.8	1.8	1.7
Delay disc. indifference point, 24s delay	0.0	0.1	0.1	0.1	-0.2	-0.2	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.1	0.2	0.1	0.6
Delay disc. indifference point, 8s delay	1.1	1.9	2.3	1.3	-1.4	-1.5	-1.3
Indifference point function ln k	0.5	1.5	1.9	1.0	-1.4	-1.1	-1.4
Indifference point function log k	0.5	1.5	1.9	1.0	-1.4	-1.1	-1.4
Patch foraging total patch changes 0 sec	0.2	0.6	0.8	-0.6	0.9	0.7	0.8
Patch foraging total patch changes 12 sec	0.2	0.3	0.5	-0.5	0.7	0.4	0.5
Patch foraging total patch changes 18 sec	0.1	0.3	0.6	-0.3	0.7	0.4	0.7
Patch foraging total patch changes 24 sec	0.4	1.4	1.9	-1.1	1.4	1.1	1.0
Patch foraging total patch changes 6 sec	1.4	2.4	3.2	-1.2	1.6	1.5	1.8
Patch foraging time to switch 0 sec	1.6	6.3	6.9	2.5	-2.6	-2.5	-2.3
Patch foraging water rate 0 sec	0.6	2.4	2.7	-1.6	1.6	1.7	1.3
Patch foraging water rate 12 sec	0.3	1.1	1.8	-1.4	1.0	1.1	0.6
Patch foraging water rate 18 sec	1.4	3.2	4.1	-2.0	1.7	1.9	1.4
Patch foraging water rate 24 sec	2.5	3.5	5.2	-2.3	1.7	2.1	1.4
Patch foraging water rate 6 sec	0.7	1.0	1.2	-1.1	1.0	1.1	0.9
Seeking ratio, delayed vs. immediate footshock	0.9	1.2	1.9	-1.1	1.0	0.9	1.4
Distance traveled before self-admin	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.0
Distance traveled after self-admin	4.5	7.8	9.1	-3.0	2.5	3.0	2.7
Extensor digitorum longus weight	8.9	35.6	41.7	5.7	-6.5	-5.9	-5.8
Bone: elastic displacement	0.0	0.1	0.1	-0.4	-0.2	0.1	-0.1
Bone: elastic work	0.1	0.1	0.4	-0.6	0.1	0.3	0.2
Bone: endosteal estimation	1.5	3.6	4.0	-2.0	1.8	2.0	1.8
Bone: endosteal perimeter	0.4	1.0	1.2	-1.0	0.8	1.1	1.0
Epididymis fat weight	0.2	0.9	1.8	1.3	-0.7	-1.1	-0.5
Delta time in closed arm before/after self-admin	1.0	0.9	1.3	0.9	-1.2	-0.9	-0.8
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.1	0.7	0.3	0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.1	-0.1	0.2	0.1
Delay discount exponential model param	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.3	0.2	0.6	0.2
Active lever presses in extinction session 6	0.4	0.4	0.5	-0.6	0.7	0.7	0.7
Bone: final force	0.0	0.0	0.1	-0.1	0.1	0.2	0.3
Bone: final moment	0.0	0.0	0.1	-0.2	0.0	0.2	0.3
Food consumed during 24 hour testing period	2.1	4.2	4.8	-2.2	2.1	2.1	1.8
Glucose	1.0	1.5	2.2	-1.1	1.1	1.5	1.3
Heart weight	0.7	1.1	1.4	0.9	-1.2	-1.0	-1.0
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	-0.2	-0.2	-0.4
Intermittent access intake day 1-15 change	0.1	0.5	0.8	0.4	-0.7	-0.6	-0.9
Intermittent access intake escalation	0.2	0.9	1.2	0.7	-1.0	-0.9	-1.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.3	0.3	0.3	0.4
Intermitt. access day 1 inactive lever presses	0.3	4.0	4.1	-2.0	2.0	2.0	2.0
Intermitt. access day 15 inactive lever presses	0.7	3.7	4.3	-1.9	2.1	1.9	1.8
Intermitt. access escalation Index	0.2	0.6	0.9	0.9	-0.9	-0.6	-0.6
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.4	0.3	0.3	0.3
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.5	0.1	0.2	-0.1
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.4	-1.2	0.9	0.9	0.7
Intermittent access total infusions	0.1	0.2	0.3	-0.6	0.4	0.2	0.2
Intermittent access day 1 locomotion	0.2	0.4	0.6	-0.8	0.7	0.6	0.6
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.3
Intermittent access total locomotion	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.3
Intermittent access standard deviation	0.3	1.4	1.7	-1.3	1.1	1.1	1.2
Left kidney weight	0.0	0.0	0.1	-0.2	-0.0	-0.3	-0.3
Right kidney weight	0.0	0.0	0.1	0.1	0.1	-0.3	-0.0
Cocaine induced anxiety	0.1	0.4	0.6	0.7	-0.5	-0.8	-0.4
Post-drug Anxiety	0.1	0.1	0.2	0.5	-0.1	-0.3	0.0
Baseline Anxiety	0.7	1.1	1.8	-1.3	0.7	1.3	0.9
Tail length	0.3	1.5	2.1	-1.4	1.3	1.1	1.0
Length with tail	0.4	1.8	2.6	-1.6	1.3	1.3	1.1
Length without tail	0.2	1.1	1.6	-1.2	0.9	1.2	0.8
Times rat made contact with spout	0.1	0.1	0.2	-0.1	0.3	0.3	0.4
Lifetime Intake	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0
Liver weight, left	0.3	0.5	0.9	-0.3	0.9	0.5	0.9
Liver weight, right	1.0	1.8	2.5	-1.4	1.6	1.2	1.2
Locomotor activity	0.9	1.3	2.4	-1.5	1.1	1.2	0.7
Locomotor testing distance	0.3	0.8	1.6	-1.3	0.8	0.9	0.4
Locomotor testing rearing	0.2	0.6	1.1	-1.1	0.6	0.7	0.5
Locomotion in novel chamber	0.0	0.0	0.0	-0.1	0.0	0.2	-0.2
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	-0.0	0.3	0.4	0.6
Fecal boli incidents, locomotor time 1	0.4	0.9	1.3	0.9	-1.2	-0.8	-0.9
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.4	-0.2	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.4	1.2	-1.2	-0.8	-0.7
Bouts of movement, locomotor time 1	1.2	1.5	1.9	1.4	-1.2	-1.3	-1.1
Total resting periods, locomotor time 1	0.9	1.1	1.5	1.2	-0.9	-1.1	-0.9
Rest time, locomotor task time 1	0.7	1.2	1.7	-1.3	1.1	1.2	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.4	-0.6	-0.5	-0.3
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.5	-0.2	-0.5	0.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	-0.1	0.0	0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.2	0.1	0.1	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.1
Rest time, locomotor task time 2	0.7	1.1	1.8	-1.4	0.9	1.2	0.5
Distance moved, locomotor task time 2	1.2	1.7	2.1	1.2	-1.3	-1.5	-1.2
Vertical activity count, locomotor time 2	0.1	0.2	0.4	0.6	-0.3	-0.6	-0.1
Light reinforcement 1	0.2	1.0	1.5	-0.9	1.2	0.7	1.0
Light reinforcement 2	0.1	0.1	0.2	0.2	-0.1	-0.5	-0.4
Bone: marrow area	1.4	3.5	4.0	-1.9	1.8	2.0	1.7
Bone: maximum diameter	0.0	0.1	0.1	0.4	-0.3	-0.3	0.1
Bone: maximum force	0.2	0.4	0.4	-0.6	0.4	0.6	0.7
Bone: maximum moment	0.2	0.4	0.5	-0.7	0.5	0.7	0.7
Mean time between licks in bursts	1.0	6.2	6.7	2.3	-2.6	-2.5	-2.6
Mean num. licks in bursts	0.2	0.7	0.9	-0.7	1.0	0.7	0.9
Cd content in liver	4.0	4.5	5.7	2.1	-2.4	-2.1	-1.8
Co content in liver	0.1	0.2	0.3	0.4	-0.3	-0.3	-0.5
Cu content in liver	0.0	0.0	0.0	-0.2	0.2	0.1	0.1
Fe content in liver	0.7	0.9	1.1	1.0	-0.8	-1.0	-0.9
K content in liver	0.2	0.2	0.3	-0.2	0.6	0.3	0.5
Mg content in liver	0.0	0.0	0.0	0.2	0.2	-0.1	0.1
Mn content in liver	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.4
Na content in liver	0.4	0.5	0.9	-0.3	0.7	0.7	0.9
Rb content in liver	1.8	2.1	2.6	1.6	-1.4	-1.4	-1.4
Se content in liver	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0
Sr content in liver	0.1	0.1	0.2	-0.4	-0.2	0.1	-0.2
Zn content in liver	0.2	0.3	0.3	0.6	-0.5	-0.4	-0.6
Bone: minimum diameter	4.9	9.5	10.2	-3.2	3.1	3.0	3.0
Time in familiar zone, hab. session 1	0.4	0.5	0.7	-0.8	0.6	0.8	0.5
Time in novel zone, hab. session 1	1.3	1.4	2.1	1.5	-1.0	-1.3	-0.9
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.4	0.5	0.3	0.4
Total locomotion distance, hab. session 1	2.2	3.2	4.0	-2.0	1.9	1.7	1.5
Locomotion velocity, hab. session 1	2.1	2.9	3.6	-1.9	1.8	1.7	1.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.1
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.7	-0.5	-0.7	-0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.2	0.3	0.2
Total locomotion distance, hab. session 2	1.0	1.3	1.6	-1.3	1.1	1.1	1.0
Locomotion velocity, hab. session 2	1.1	1.4	1.8	-1.3	1.1	1.2	1.1
Novel to familiar place preference ratio	0.1	0.1	0.3	0.5	-0.1	-0.4	-0.2
Novelty place preference	0.3	0.4	0.9	1.0	-0.4	-0.7	-0.4
Time in novel zone, NPP test	0.2	0.3	0.7	0.8	-0.2	-0.6	-0.3
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	0.1	0.1	0.2
Total locomotion distance, NPP test	0.4	0.6	1.0	-1.0	0.8	0.7	0.6
Locomotion velocity, NPP test	0.2	0.2	0.5	-0.7	0.5	0.5	0.3
Intraocular pressure	0.7	1.1	1.3	1.2	-1.1	-1.0	-1.0
Delta distance traveled before/after self-admin	4.7	5.2	5.6	-2.4	2.3	2.3	2.1
Delta ambulatory time before/after self-admin	1.5	2.6	3.1	-1.8	1.7	1.6	1.4
Parametrial fat weight	0.8	1.9	2.5	-1.3	1.6	1.3	1.4
Pavlov. Cond. lever latency	0.5	0.6	1.0	0.7	-1.0	-0.7	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.3	0.1	0.2	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.2
Pavlov. Cond. index score	0.1	0.2	0.3	-0.4	0.5	0.4	0.3
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.5	0.6	0.5	0.4
Pavlov. Cond. lever contacts	0.4	0.5	0.7	-0.7	0.9	0.6	0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	0.0	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	0.2	0.0	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.5	0.6	0.5	0.4
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.5	0.6	0.5	0.4
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	-0.0	-0.2	-0.0
Pavlov. Cond. magazine entry latency	0.5	0.7	0.9	0.6	-1.0	-0.8	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.3	-0.0	-0.3
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	-0.4	-0.2	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.4	0.1	-0.6	-0.4	-0.6
Pavlov. Cond. lever contacts	0.1	0.2	0.3	-0.6	0.4	0.4	0.3
Pavlov. Cond. magazine entry number	0.9	1.2	1.6	-0.8	1.3	1.0	1.2
Pavlov. Cond. intertrial magazine entries	0.8	1.7	2.2	-1.1	1.5	1.2	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.0	-0.4	-0.2	-0.4
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.3
Time in closed arm before self-admin	0.1	0.2	0.3	-0.5	0.6	0.4	0.2
Time in closed arm after self-admin	0.1	0.1	0.3	0.1	-0.5	-0.2	-0.3
Time in open arm before self-admin	0.1	0.2	0.4	-0.5	-0.2	0.1	-0.6
Time in open arm after self-admin	0.6	0.7	1.2	-0.4	1.1	0.7	0.9
Bone: periosteal estimation	0.7	1.6	1.7	-1.3	1.2	1.3	1.3
Bone: periosteal perimeter	0.3	0.6	0.8	-0.7	0.6	0.8	0.9
Bone: post-yield work	0.0	0.0	0.0	0.1	0.1	0.0	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.3	0.0	-0.1	-0.2
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	-0.4	0.2	0.0	-0.0
Progressive ratio test 1 inactive lever presses	1.5	3.8	4.3	-1.9	2.1	1.7	2.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	-0.0	-0.1	-0.0
Progressive ratio test 2 inactive lever presses	0.6	1.8	2.1	-1.4	1.3	1.2	1.5
Incentive Sensitization - Responses	0.1	0.2	0.3	0.5	-0.5	-0.4	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.4	-0.5	-0.4	-0.2
Sum of active levers in priming session hrs 5-6	0.6	0.5	0.8	-0.7	0.6	0.7	0.9
Progressive ratio	0.0	0.0	0.1	-0.3	0.1	0.2	-0.1
Food seeking constrained by brief footshock	0.1	0.2	0.3	0.4	-0.2	-0.5	-0.4
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	0.0	0.5	0.1	0.6
Retroperitoneal fat weight	0.0	0.0	0.0	0.1	0.1	0.0	0.1
Reaction time number correct	0.0	0.0	0.1	-0.1	0.0	0.4	0.2
Reaction time mean minus median	0.2	1.1	1.7	1.3	-0.9	-1.1	-0.8
Reaction time mean minus median AUC	0.2	1.5	2.8	1.7	-1.0	-1.2	-0.8
Reaction time num false alarms	0.0	0.0	0.1	0.2	0.1	-0.4	0.1
Reaction time num false alarms AUC	0.1	0.2	0.5	0.5	-0.2	-0.7	-0.2
Reaction time trials correct on left	0.0	0.0	0.1	-0.1	0.0	0.4	0.2
Reaction time trials on left	0.0	0.0	0.1	-0.1	-0.1	0.3	0.1
Reaction time mean	0.6	1.3	2.0	1.4	-1.0	-1.3	-0.8
Reaction time mean AUC	0.5	1.3	2.0	1.4	-1.0	-1.2	-0.8
Median of all reaction times	0.7	1.0	1.4	1.2	-0.9	-1.1	-0.7
Reaction time omissions	0.9	1.5	1.6	1.2	-1.2	-1.2	-1.3
Reaction time false alarm rate	0.2	0.3	0.7	0.5	-0.2	-0.8	-0.3
Reaction time premature initiation rate	0.1	0.2	0.3	-0.2	0.6	0.2	0.5
Reaction time premature initiations	0.1	0.2	0.4	-0.2	0.6	0.3	0.6
Std. dev. reaction times	0.3	1.1	1.5	1.2	-0.9	-1.1	-0.9
Reaction time trials completed	0.0	0.0	0.1	-0.1	-0.1	0.3	0.1
Reaction time trials AUC	0.0	0.0	0.0	0.1	-0.2	0.2	-0.0
Run reversals in cocaine runway, females	1.6	1.8	2.3	-1.5	1.5	1.3	1.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.3	-0.4	-0.1	-0.5
Latency to leave start box in cocaine runway	1.7	2.4	3.0	-1.2	1.7	1.5	1.7
Latency to leave start box in cocaine runway, F	3.6	4.4	5.4	-1.8	2.3	2.1	2.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	0.2	0.2	0.4
Std. dev. time between licks in bursts	0.6	1.2	1.6	0.7	-1.2	-1.1	-1.3
Total sessions with >9 infusions	1.3	1.6	1.9	1.2	-1.3	-1.4	-1.2
Short access day 1 total inactive lever presses	1.1	2.1	2.8	-1.5	1.1	1.5	1.7
Short access day 10 total inactive lever presses	0.4	2.8	3.0	-1.7	1.5	1.7	1.7
Short access day 1 total infusions	0.1	0.3	0.4	-0.5	0.5	0.4	0.7
Short access day 10 total infusions	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.1
Short access total infusions	0.2	0.2	0.3	0.5	-0.6	-0.5	-0.3
Short access day 1 locomotion	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.2
Short access total locomotion	0.2	0.3	0.4	0.4	-0.5	-0.6	-0.6
One hour access (0.3 mA shock)	0.2	0.3	0.3	-0.6	0.5	0.5	0.6
Compulsive drug intake	0.5	0.7	1.1	-0.5	0.8	0.9	1.1
One hour access (shock baseline)	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.4
Social response proportion	1.2	1.5	2.2	-0.6	1.4	1.2	1.5
Social responses	0.6	0.8	1.0	-0.5	0.9	1.0	1.0
Social time	0.3	0.5	0.6	-0.4	0.8	0.7	0.8
Soleus weight	0.1	0.2	0.5	-0.2	-0.7	-0.1	-0.3
Bone: stiffness	0.2	0.3	0.6	-0.3	0.6	0.6	0.8
Tibialis anterior weight	4.0	13.9	16.3	3.6	-4.0	-3.7	-3.5
Time to tail flick, vehicle, before self-admin	1.0	1.2	1.5	-1.2	1.2	1.2	0.8
Time to tail flick, vehicle, after self-admin	1.1	2.3	3.2	-1.8	1.3	1.8	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	-0.2	0.0	-0.4
Time to tail flick, test, after self-admin	1.1	1.2	1.5	-1.1	1.2	1.0	1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.1	0.1	-0.3	0.2	0.3	0.1
Delta time to tail flick, test, before/after SA	0.4	0.5	0.9	-0.3	0.8	0.6	0.9
Tibia length	0.0	0.0	0.1	-0.3	0.3	0.1	0.1
Ambulatory time before self-admin	0.0	0.0	0.1	-0.2	-0.0	0.3	0.1
Ambulatory time after self-admin	4.1	6.5	7.4	-2.6	2.4	2.7	2.5
Bone: tissue strength	0.7	0.7	0.9	-1.0	0.8	0.8	0.8
Total heroin consumption	0.6	0.7	1.2	-1.1	0.7	1.0	0.5
Bone: trabecular number	0.0	0.1	0.2	0.4	-0.1	-0.3	0.0
Bone: trabecular spacing	0.3	0.4	0.7	0.8	-0.5	-0.7	-0.4
Bone: trabecular thickness	0.4	0.5	0.6	-0.8	0.6	0.7	0.7
Bone: trabecular tissue density	0.9	1.5	1.7	1.3	-1.2	-1.2	-1.2
Water consumed over 24 hours	1.0	2.0	2.2	-1.3	1.4	1.5	1.4
Number of responses in last shaping day	0.2	0.2	0.4	0.6	-0.4	-0.6	-0.2