Hub : Genes

Ugt2a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Ugt2a3	0.12	0.07	1.2e-11	0.09	0.08	0.08	0.08	5.5e-10	1.9e-09	1.9e-09	2.2e-09
2	Liver	gene expression	Ugt2a3	0.5	0.18	0.0e+00	0.27	0.23	0.25	0.27	7.8e-30	6.1e-25	1.2e-27	5.5e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.1	0.2	-0.4	0.1
Area under the delay curve	0.1	0.1	0.2	0.5	-0.0
BMI with tail	1.5	5.1	6.1	-2.5	2.0
BMI without tail	1.2	3.7	4.6	-2.1	1.7
Body weight	0.1	0.2	0.5	-0.7	0.1
Weight adjusted by age	0.7	1.1	1.3	-0.9	1.1
Bone surface	0.1	0.2	0.4	0.6	0.0
Bone volume	0.4	0.8	1.2	1.1	-0.6
Breakpoint value in progressive ratio session	0.3	0.4	0.7	0.8	-0.3
Number of licking bursts	0.1	0.2	0.2	-0.5	0.4
Context. condit. distance diff. score	0.1	0.1	0.1	0.3	-0.4
Locomotion velocity, session 1	0.7	0.7	0.8	-0.8	0.9
Locomotion distance, session 1	0.2	0.2	0.2	0.4	-0.5
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	-0.1
Locomotion distance, session 2	0.1	0.1	0.2	0.4	-0.4
Locomotion velocity, session 3	0.6	0.6	0.7	0.8	-0.8
Locomotion distance, session 3	0.1	0.1	0.1	0.1	-0.3
Stereotopy head waving bouts, day 3	0.6	0.7	0.8	-0.8	0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.2	-0.4	0.5
Locomotion velocity, session 7	3.3	3.6	3.7	1.8	-1.9
Locomotion distance, session 7	2.1	2.7	2.7	1.6	-1.6
Stereotopy head waving bouts, day 7	0.7	0.8	0.9	-0.8	1.0
Stereotopy head waving duration, day 7	0.5	0.6	0.8	-0.7	0.9
Locomotion velocity, session 8	0.0	0.0	0.0	-0.2	-0.0
Locomotion distance, session 8	0.5	0.7	0.8	0.8	-0.9
Degree of sensitization distance	1.7	1.8	2.1	1.5	-1.2
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.3	0.4
Conditioned locomotion	0.5	0.6	0.6	-0.8	0.7
Cocaine response after cond. corrected	0.7	0.8	1.0	0.8	-1.0
Cocaine response after cond. not corrected	0.6	0.7	0.8	0.7	-0.9
Cocaine response before conditioning	0.2	0.2	0.3	-0.4	0.6
Saline control response	0.8	1.0	1.1	1.0	-1.0
Bone: connectivity density	0.5	0.7	1.3	-1.2	0.3
Bone: cortical apparent density	0.2	0.3	0.5	-0.7	-0.2
Bone: cortical area	0.8	1.2	2.0	1.4	-0.7
Bone: cortical porosity	1.7	1.9	2.7	-1.6	1.0
Bone: cortical porosity	3.1	3.3	4.0	-2.0	1.6
Bone: cortical thickness	0.1	0.2	0.3	-0.2	0.6
Bone: cortical thickness	0.4	0.4	0.7	0.9	-0.4
Bone: cortical tissue density	0.3	0.4	0.7	-0.8	-0.1
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.6	0.7
Condit. Reinf. active-inactive response ratio	2.3	2.4	2.4	-1.6	1.6
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	-0.1
Condit. Reinf. inactive responses	1.6	2.0	2.1	1.5	-1.3
Incentive salience index mean	0.0	0.0	0.0	-0.1	0.0
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.2	0.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.3	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.5	-0.6
Condit. Reinf. active responses	0.2	0.2	0.3	0.4	-0.6
Condit. Reinf. inactive responses	0.3	0.4	0.4	0.6	-0.7
Condit. Reinf. lever presses	0.6	0.8	0.8	0.9	-0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	0.5	-0.7
Conditioned reinforcement - actives	0.1	0.2	0.4	0.6	0.3
Conditioned reinforcement - inactives	1.2	1.7	2.9	1.7	-0.7
Conditioned locomotion	0.4	0.5	1.0	1.0	-0.1
Patch foraging indifference point 0 sec	0.2	0.4	0.5	0.5	-0.7
Patch foraging indifference point AUC	3.1	4.4	4.9	2.0	-2.2
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	0.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	-0.2	0.9
Delay disc. indifference point, 2s delay	3.7	4.1	4.3	2.1	-2.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.5	0.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.6	-0.6
Delay disc. indifference point, 8s delay	0.8	1.0	1.5	-0.6	1.2
Indifference point function ln k	1.2	2.0	2.7	-1.2	1.7
Indifference point function log k	1.2	2.0	2.7	-1.2	1.7
Patch foraging total patch changes 0 sec	0.3	0.6	0.8	0.6	-0.9
Patch foraging total patch changes 12 sec	0.6	0.8	0.8	0.9	-0.9
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	0.4	-0.7
Patch foraging total patch changes 24 sec	0.9	1.5	1.8	1.3	-1.1
Patch foraging total patch changes 6 sec	2.0	3.0	3.0	1.7	-1.7
Patch foraging time to switch 0 sec	3.2	6.5	7.2	-2.4	2.7
Patch foraging water rate 0 sec	1.4	3.0	3.0	1.7	-1.7
Patch foraging water rate 12 sec	0.3	0.7	1.0	1.0	-0.6
Patch foraging water rate 18 sec	1.6	2.4	2.4	1.6	-1.6
Patch foraging water rate 24 sec	1.0	1.5	1.7	1.1	-1.3
Patch foraging water rate 6 sec	0.9	1.3	1.4	1.2	-1.1
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	0.9	0.9	-0.9
Distance traveled before self-admin	0.0	0.0	0.0	0.0	0.1
Distance traveled after self-admin	4.3	5.3	6.3	2.5	-2.1
Extensor digitorum longus weight	10.8	42.3	44.5	-6.7	6.3
Bone: elastic displacement	0.5	0.5	0.8	-0.9	0.5
Bone: elastic work	0.3	0.4	0.7	-0.8	0.2
Bone: endosteal estimation	2.0	4.3	5.8	2.4	-1.7
Bone: endosteal perimeter	0.4	0.8	1.2	1.1	-0.5
Epididymis fat weight	0.0	0.0	0.0	0.1	-0.2
Delta time in closed arm before/after self-admin	0.7	0.6	0.9	-0.6	1.0
Delta time in open arm before/after self-admin	0.3	0.3	0.4	0.5	-0.6
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.0	0.4
Delay discount exponential model param	0.2	0.2	0.3	-0.6	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.1	0.4
Active lever presses in extinction session 6	0.5	0.5	0.8	0.9	-0.5
Bone: final force	0.3	0.4	0.7	0.9	-0.4
Bone: final moment	0.3	0.4	0.8	0.9	-0.3
Food consumed during 24 hour testing period	1.9	2.6	2.6	1.6	-1.6
Glucose	0.8	1.2	1.3	1.0	-1.2
Heart weight	0.4	0.7	0.9	-0.6	1.0
Delay discount hyperbolic model param	0.4	0.4	0.6	-0.8	0.5
Intermittent access intake day 1-15 change	0.2	0.4	0.6	-0.4	0.8
Intermittent access intake escalation	0.3	0.5	0.9	-0.5	0.9
Intermittent access intake escalation 2	1.0	1.1	2.1	1.4	-0.4
Intermitt. access day 1 inactive lever presses	0.8	3.1	3.9	2.0	-1.5
Intermitt. access day 15 inactive lever presses	2.2	4.4	4.7	2.2	-2.0
Intermitt. access escalation Index	1.4	1.9	2.7	-1.6	1.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	0.1
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.2	0.2
Intermittent access terminal intake (last 3 days)	0.8	1.0	1.6	1.3	-0.6
Intermittent access total infusions	0.0	0.0	0.0	0.2	-0.2
Intermittent access day 1 locomotion	0.4	0.6	0.8	0.9	-0.6
Intermittent access day 15 total locomotion	0.4	0.8	1.5	1.2	-0.2
Intermittent access total locomotion	0.1	0.1	0.2	0.5	0.1
Intermittent access standard deviation	0.6	1.2	1.3	1.2	-1.0
Left kidney weight	0.1	0.2	0.3	0.5	-0.4
Right kidney weight	0.2	0.7	0.9	0.9	-0.8
Cocaine induced anxiety	0.2	0.3	0.6	-0.7	0.4
Post-drug Anxiety	0.0	0.0	0.0	-0.2	0.1
Baseline Anxiety	0.3	0.4	0.6	0.8	-0.4
Tail length	0.5	1.9	2.2	1.3	-1.5
Length with tail	0.5	2.2	2.6	1.4	-1.6
Length without tail	0.4	1.1	1.3	1.0	-1.1
Times rat made contact with spout	0.2	0.2	0.2	0.4	-0.4
Lifetime Intake	0.1	0.1	0.1	-0.4	0.2
Liver weight, left	0.8	1.4	1.5	1.1	-1.2
Liver weight, right	1.5	2.6	3.3	1.3	-1.8
Locomotor activity	0.7	1.0	1.6	1.2	-0.7
Locomotor testing distance	0.1	0.1	0.2	0.5	-0.1
Locomotor testing rearing	0.0	0.0	0.0	0.2	-0.1
Locomotion in novel chamber	0.0	0.0	0.0	-0.1	0.1
Locomotion in novel chamber post-restriction	0.3	0.5	0.5	0.7	-0.6
Fecal boli incidents, locomotor time 1	1.7	2.5	3.1	-1.8	1.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.2	0.1
Time >=10cm from walls, locomotor time 1	1.7	1.8	1.8	-1.3	1.3
Bouts of movement, locomotor time 1	1.4	1.6	1.9	-1.4	1.1
Total resting periods, locomotor time 1	1.0	1.1	1.4	-1.2	0.9
Rest time, locomotor task time 1	0.1	0.2	0.3	0.2	-0.6
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.2	0.3
Vertical activity count, locomotor time 1	0.2	0.4	0.6	0.7	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.6	0.6	-0.8	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.4	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.4	0.0
Rest time, locomotor task time 2	0.3	0.4	0.5	0.6	-0.7
Distance moved, locomotor task time 2	1.3	1.6	2.2	-1.5	1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.5	-0.2
Light reinforcement 1	0.5	1.3	1.4	1.2	-1.1
Light reinforcement 2	0.0	0.0	0.0	0.0	-0.1
Bone: marrow area	1.9	4.1	5.5	2.4	-1.6
Bone: maximum diameter	0.2	0.3	0.6	0.8	-0.1
Bone: maximum force	0.6	1.0	1.6	1.2	-0.6
Bone: maximum moment	0.6	1.1	1.8	1.3	-0.6
Mean time between licks in bursts	1.6	4.0	4.1	-2.0	1.9
Mean num. licks in bursts	0.8	1.2	1.3	1.1	-1.1
Cd content in liver	4.6	5.1	6.2	-2.0	2.5
Co content in liver	0.3	0.3	0.4	-0.6	0.5
Cu content in liver	0.0	0.1	0.1	0.3	0.0
Fe content in liver	0.1	0.1	0.1	-0.1	0.4
K content in liver	0.4	0.4	0.6	0.4	-0.8
Mg content in liver	0.1	0.1	0.1	0.2	-0.3
Mn content in liver	0.2	0.2	0.4	-0.0	0.6
Na content in liver	0.5	0.5	0.8	0.5	-0.9
Rb content in liver	1.6	1.9	2.0	-1.3	1.4
Se content in liver	0.1	0.1	0.1	0.2	-0.4
Sr content in liver	0.2	0.2	0.3	0.2	0.5
Zn content in liver	1.0	1.1	1.8	-1.4	0.7
Bone: minimum diameter	7.9	14.3	16.3	4.0	-3.5
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.2	-0.2
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.3	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	-0.4
Total locomotion distance, hab. session 1	1.6	2.2	2.5	1.4	-1.6
Locomotion velocity, hab. session 1	1.1	1.5	1.7	1.1	-1.3
Time in familiar zone, hab. session 2	0.3	0.3	0.4	-0.5	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	-0.2
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.0	0.1
Total locomotion distance, hab. session 2	0.4	0.5	0.6	0.7	-0.7
Locomotion velocity, hab. session 2	0.4	0.5	0.5	0.7	-0.7
Novel to familiar place preference ratio	0.1	0.2	0.2	0.5	-0.3
Novelty place preference	0.0	0.0	0.0	0.2	0.0
Time in novel zone, NPP test	0.1	0.2	0.2	0.5	-0.2
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	-0.0
Total locomotion distance, NPP test	0.1	0.1	0.2	0.3	-0.5
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	-0.1
Intraocular pressure	0.4	0.6	0.9	-0.9	0.6
Delta distance traveled before/after self-admin	3.4	3.5	3.9	1.8	-2.0
Delta ambulatory time before/after self-admin	1.4	1.8	1.9	1.3	-1.4
Parametrial fat weight	1.4	3.3	3.9	1.6	-2.0
Pavlov. Cond. lever latency	1.2	1.5	1.8	-1.3	1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.5	-0.3
Pavlov. Cond. index score	0.4	0.4	0.5	0.7	-0.7
Pavlov. Cond. latency score	0.5	0.6	0.6	0.8	-0.7
Pavlov. Cond. lever contacts	1.0	1.2	1.4	1.2	-1.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	-0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.4	0.6	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. response bias	0.3	0.4	0.4	0.6	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.6	-0.4
Pavlov. Cond. magazine entry latency	1.4	1.7	1.8	-1.3	1.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	-0.7	0.6
Pavlov. Cond. index score	0.7	0.9	1.1	-1.0	0.9
Pavlov. Cond. latency score	1.1	1.4	1.6	-1.3	1.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	0.1
Pavlov. Cond. magazine entry number	2.3	2.8	3.1	1.8	-1.6
Pavlov. Cond. intertrial magazine entries	2.1	3.2	3.3	1.8	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.0	-1.0	0.8
Pavlov. Cond. response bias	0.4	0.5	0.6	-0.8	0.7
Time in closed arm before self-admin	0.6	0.7	0.8	0.8	-0.9
Time in closed arm after self-admin	0.1	0.1	0.1	0.3	0.2
Time in open arm before self-admin	0.4	0.4	0.5	-0.6	0.7
Time in open arm after self-admin	0.4	0.5	0.7	0.5	-0.8
Bone: periosteal estimation	1.6	3.3	5.0	2.2	-1.2
Bone: periosteal perimeter	0.4	0.7	1.2	1.1	-0.4
Bone: post-yield work	0.3	0.4	0.8	0.9	-0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.4	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.4	0.0
Progressive ratio test 1 inactive lever presses	1.9	2.7	2.8	1.6	-1.7
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	0.7	0.1
Progressive ratio test 2 breakpoint	0.3	0.3	0.7	0.8	0.1
Progressive ratio test 2 inactive lever presses	1.0	1.6	2.3	1.5	-1.0
Incentive Sensitization - Responses	0.2	0.3	0.3	0.6	0.5
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.6	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.6	-0.1
Progressive ratio	0.0	0.0	0.1	-0.3	-0.1
Food seeking constrained by brief footshock	0.5	0.6	1.2	-1.1	0.2
Seeking ratio, punishment vs. effort	0.2	0.3	0.3	0.6	-0.6
Retroperitoneal fat weight	0.2	0.7	0.8	0.8	-0.9
Reaction time number correct	0.0	0.1	0.1	0.3	0.0
Reaction time mean minus median	0.1	0.3	0.4	-0.6	0.4
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.4	0.3
Reaction time num false alarms	0.2	0.3	0.4	0.6	-0.5
Reaction time num false alarms AUC	0.0	0.0	0.0	0.1	-0.1
Reaction time trials correct on left	0.0	0.1	0.1	0.3	0.0
Reaction time trials on left	0.0	0.0	0.1	0.3	0.1
Reaction time mean	0.3	0.5	0.6	-0.6	0.8
Reaction time mean AUC	0.2	0.3	0.5	-0.5	0.7
Median of all reaction times	0.3	0.5	0.7	-0.5	0.8
Reaction time omissions	1.0	1.5	1.6	-1.3	1.2
Reaction time false alarm rate	0.0	0.0	0.0	-0.0	-0.2
Reaction time premature initiation rate	0.4	0.5	0.6	0.8	-0.6
Reaction time premature initiations	0.4	0.8	1.2	1.1	-0.6
Std. dev. reaction times	0.1	0.2	0.2	-0.4	0.4
Reaction time trials completed	0.0	0.0	0.1	0.3	0.1
Reaction time trials AUC	0.0	0.0	0.0	0.2	0.2
Run reversals in cocaine runway, females	2.1	2.1	2.2	1.4	-1.5
Run reversals in cocaine runway, males	0.6	0.6	0.7	-0.8	0.7
Latency to leave start box in cocaine runway	1.6	1.8	2.4	1.1	-1.5
Latency to leave start box in cocaine runway, F	4.3	4.9	5.2	2.1	-2.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.6	-0.8	0.1
Std. dev. time between licks in bursts	0.9	1.3	1.5	-1.2	1.0
Total sessions with >9 infusions	1.2	1.5	1.5	-1.2	1.2
Short access day 1 total inactive lever presses	0.6	0.8	0.9	1.0	-0.8
Short access day 10 total inactive lever presses	0.5	1.2	1.3	1.1	-1.0
Short access day 1 total infusions	0.1	0.1	0.1	-0.1	-0.4
Short access day 10 total infusions	0.2	0.3	0.4	-0.6	0.4
Short access total infusions	0.6	0.7	1.0	-1.0	0.7
Short access day 1 locomotion	0.0	0.0	0.0	-0.1	0.2
Short access day 10 total locomotion	0.0	0.1	0.1	0.3	0.2
Short access total locomotion	0.1	0.1	0.2	-0.1	0.5
One hour access (0.3 mA shock)	0.5	0.5	1.0	1.0	-0.3
Compulsive drug intake	0.4	0.4	0.8	0.1	-0.9
One hour access (shock baseline)	0.1	0.1	0.2	0.4	0.3
Social response proportion	1.7	1.9	2.2	1.3	-1.5
Social responses	0.8	1.0	1.0	1.0	-1.0
Social time	0.4	0.6	1.0	1.0	-0.5
Soleus weight	0.3	0.8	0.9	-1.0	0.9
Bone: stiffness	1.7	2.7	4.0	2.0	-1.2
Tibialis anterior weight	3.5	11.8	13.3	-3.2	3.7
Time to tail flick, vehicle, before self-admin	1.5	1.6	1.6	1.2	-1.3
Time to tail flick, vehicle, after self-admin	0.9	1.2	1.6	1.3	-0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	0.2
Time to tail flick, test, after self-admin	1.9	2.0	2.4	1.6	-1.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.6	0.0
Delta time to tail flick, test, before/after SA	1.1	1.1	1.1	1.0	-1.1
Tibia length	0.3	0.8	1.2	1.1	-0.7
Ambulatory time before self-admin	0.0	0.0	0.1	0.3	0.0
Ambulatory time after self-admin	3.6	4.3	4.7	2.2	-2.0
Bone: tissue strength	0.7	0.7	1.0	0.6	-1.0
Total heroin consumption	0.4	0.5	0.8	0.9	-0.4
Bone: trabecular number	0.1	0.1	0.2	-0.5	-0.3
Bone: trabecular spacing	0.1	0.1	0.1	0.3	0.2
Bone: trabecular thickness	0.1	0.1	0.2	0.0	-0.4
Bone: trabecular tissue density	0.5	0.7	1.1	-0.6	1.0
Water consumed over 24 hours	1.2	1.6	1.7	1.3	-1.2
Number of responses in last shaping day	0.3	0.3	0.5	-0.7	0.3