Hub : Genes

Ube2z

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ube2z	0.05	0.04	3.5e-05	0.03	0.03	0.02	0.03	3.2e-04	1.3e-04	4.1e-03	2.8e-04
2	Liver	mRNA stability	Ube2z	0.03	0.02	1.1e-04	0.02	0.03	0.02	0.02	2.8e-03	2.6e-04	2.7e-03	1.6e-03
3	BLA	gene expression	Ube2z	0.06	0.05	2.0e-03	0.02	0.04	0.02	0.03	3.4e-02	5.5e-03	3.9e-02	1.1e-02
4	PL	gene expression	Ube2z	0.06	0.06	2.9e-05	0.03	0.04	0.03	0.04	2.4e-04	1.0e-04	1.5e-04	8.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.1	2.0	3.1	1.8	1.5	-1.5	-0.4
Area under the delay curve	0.1	0.1	0.1	-0.4	-0.4	0.4	-0.2
BMI with tail	17.2	59.4	82.5	9.1	8.5	-8.2	-3.9
BMI without tail	1.4	4.3	6.8	2.6	2.3	-2.2	-0.6
Body weight	1.3	5.6	6.1	2.4	2.3	-2.5	-2.4
Weight adjusted by age	0.2	0.3	0.4	-0.6	-0.5	0.5	0.3
Bone surface	0.4	0.8	1.0	1.0	0.9	-1.0	-0.6
Bone volume	1.2	2.1	2.5	1.6	1.5	-1.6	-1.1
Breakpoint value in progressive ratio session	2.2	2.7	2.9	-1.7	-1.6	1.7	1.5
Number of licking bursts	0.8	1.4	2.7	-0.8	-1.0	1.0	1.6
Context. condit. distance diff. score	0.7	0.9	1.2	1.1	1.0	-1.0	-0.5
Locomotion velocity, session 1	0.1	0.1	0.5	0.0	-0.1	0.1	0.7
Locomotion distance, session 1	4.3	5.4	6.2	-2.4	-2.5	2.4	2.0
Locomotion velocity, session 2	0.9	1.1	1.9	-1.4	-1.2	1.1	-0.1
Locomotion distance, session 2	6.0	8.4	9.0	-2.9	-3.0	3.0	2.7
Locomotion velocity, session 3	0.6	0.7	2.0	0.4	0.6	-0.6	-1.4
Locomotion distance, session 3	1.2	1.3	1.8	-1.3	-1.2	1.3	0.6
Stereotopy head waving bouts, day 3	4.1	4.9	5.6	2.3	2.3	-2.4	-1.8
Stereotopy head waving duration, day 3	3.4	4.1	4.6	2.0	2.0	-2.1	-1.9
Locomotion velocity, session 7	1.0	1.1	1.6	-1.3	-1.2	1.1	0.3
Locomotion distance, session 7	5.5	7.0	8.8	-2.9	-3.0	2.8	1.7
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	0.5	0.6	-0.6	-0.3
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.5	0.7	-0.6	-0.7
Locomotion velocity, session 8	0.4	0.5	0.8	0.7	0.9	-0.7	-0.5
Locomotion distance, session 8	0.7	1.0	1.4	-0.9	-0.9	1.0	1.2
Degree of sensitization distance	0.1	0.1	0.3	-0.4	-0.5	0.4	0.1
Degree of sensitization stereotypy	0.3	0.3	0.7	-0.4	-0.4	0.5	0.8
Conditioned locomotion	1.4	1.7	2.0	1.4	1.3	-1.3	-1.0
Cocaine response after cond. corrected	4.5	5.4	7.7	2.8	2.6	-2.5	-0.9
Cocaine response after cond. not corrected	2.5	2.9	4.2	2.0	1.9	-1.8	-0.7
Cocaine response before conditioning	2.3	2.8	3.8	-1.9	-1.8	1.8	0.8
Saline control response	0.5	0.6	2.0	0.0	-0.4	0.5	1.4
Bone: connectivity density	0.2	0.3	0.6	0.8	0.6	-0.6	0.1
Bone: cortical apparent density	4.2	5.7	8.2	-2.9	-2.7	2.6	0.9
Bone: cortical area	0.4	0.6	0.7	0.9	0.7	-0.7	-0.6
Bone: cortical porosity	0.2	0.2	0.2	0.5	0.4	-0.5	-0.5
Bone: cortical porosity	0.3	0.4	0.5	0.7	0.6	-0.6	-0.5
Bone: cortical thickness	0.1	0.1	0.3	0.2	0.2	-0.1	-0.5
Bone: cortical thickness	0.6	0.7	0.8	-0.8	-0.8	0.9	0.8
Bone: cortical tissue density	4.7	6.4	9.2	-3.0	-2.8	2.8	1.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	-1.0	-1.1	1.0	0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	0.2	-0.1	0.3
Condit. Reinf. active responses	1.0	1.2	1.3	-1.1	-1.2	1.1	1.0
Condit. Reinf. inactive responses	0.9	1.2	1.4	-1.0	-1.1	1.1	1.2
Incentive salience index mean	1.8	2.3	2.6	-1.4	-1.5	1.5	1.6
Condit. Reinf. lever presses	2.6	3.6	5.3	-1.6	-1.8	1.8	2.3
Condit. Reinf. active minus inactive responses	0.4	0.5	1.7	-0.1	-0.4	0.4	1.3
Condit. Reinf. active-inactive response ratio	1.1	1.3	4.8	0.1	-0.3	0.4	2.2
Condit. Reinf. active responses	0.1	0.2	0.4	-0.1	-0.4	0.3	0.6
Condit. Reinf. inactive responses	0.2	0.2	0.7	-0.3	-0.1	0.1	-0.9
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.8	-0.7	0.7	-0.1
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	-0.3	-0.5	0.5	0.7
Conditioned reinforcement - actives	0.4	0.6	1.0	-0.6	-0.8	0.7	1.0
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.1	-0.2	0.1	0.2
Conditioned locomotion	0.4	0.5	0.8	0.9	0.6	-0.7	0.6
Patch foraging indifference point 0 sec	1.0	1.8	2.0	1.2	1.4	-1.4	-1.3
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.3	-0.2	0.3	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.4	-0.5	0.5	0.0
Delay disc. indifference point, 16s delay	0.9	1.0	1.1	0.9	1.0	-1.0	-0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.3
Delay disc. indifference point, 24s delay	0.3	0.4	0.5	-0.7	-0.7	0.7	0.2
Delay disc. indifference point, 4s delay	1.5	1.6	2.5	-1.6	-1.4	1.4	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1
Indifference point function ln k	0.0	0.0	0.1	-0.3	-0.2	0.2	0.1
Indifference point function log k	0.0	0.0	0.1	-0.3	-0.2	0.2	0.1
Patch foraging total patch changes 0 sec	1.0	1.9	2.1	1.3	1.5	-1.4	-1.4
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.0	-0.0	0.0	0.1
Patch foraging total patch changes 18 sec	1.4	2.1	2.3	1.4	1.5	-1.5	-1.5
Patch foraging total patch changes 24 sec	0.4	0.8	0.9	0.9	1.0	-1.0	-0.6
Patch foraging total patch changes 6 sec	0.6	0.9	1.1	1.0	1.0	-1.0	-0.8
Patch foraging time to switch 0 sec	0.1	0.2	0.6	-0.3	-0.4	0.3	0.7
Patch foraging water rate 0 sec	1.3	2.8	3.2	1.7	1.8	-1.7	-1.5
Patch foraging water rate 12 sec	0.3	0.7	1.2	0.6	0.8	-0.7	-1.1
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1
Patch foraging water rate 24 sec	1.1	1.5	1.7	1.3	1.3	-1.3	-1.0
Patch foraging water rate 6 sec	0.1	0.1	0.4	0.3	0.3	-0.1	0.6
Seeking ratio, delayed vs. immediate footshock	2.3	2.9	3.5	1.7	1.6	-1.6	-1.9
Distance traveled before self-admin	1.8	2.3	5.3	-0.9	-1.2	1.3	2.3
Distance traveled after self-admin	0.2	0.2	0.7	0.4	0.2	-0.1	0.8
Extensor digitorum longus weight	0.9	3.4	4.7	1.6	1.8	-1.8	-2.2
Bone: elastic displacement	0.1	0.1	0.1	0.3	0.2	-0.3	0.2
Bone: elastic work	0.0	0.0	0.0	0.1	-0.0	-0.0	0.1
Bone: endosteal estimation	0.1	0.2	0.3	0.5	0.4	-0.5	-0.4
Bone: endosteal perimeter	0.3	0.7	0.9	1.0	0.9	-0.9	-0.4
Epididymis fat weight	0.1	0.4	0.9	0.9	0.6	-0.6	0.3
Delta time in closed arm before/after self-admin	0.7	0.6	1.9	0.4	0.4	-0.5	-1.4
Delta time in open arm before/after self-admin	1.0	1.0	1.4	-1.2	-1.0	1.1	0.6
Diff in mean of infusions in LGA sessions	1.3	1.6	2.3	-1.1	-1.3	1.2	1.5
Delay discount exponential model param	0.2	0.2	0.3	0.5	0.5	-0.5	0.2
Extinction: sum of active levers before priming	0.9	1.0	1.5	-1.1	-1.2	1.1	0.4
Active lever presses in extinction session 6	0.1	0.1	0.2	0.3	0.4	-0.3	-0.0
Bone: final force	0.2	0.3	0.6	0.7	0.4	-0.4	0.5
Bone: final moment	0.2	0.3	0.7	0.8	0.5	-0.5	0.4
Food consumed during 24 hour testing period	1.6	2.2	2.6	-1.6	-1.6	1.6	1.1
Glucose	2.1	3.4	4.2	1.7	1.8	-1.8	-2.1
Heart weight	1.0	1.5	1.9	1.4	1.2	-1.3	-0.9
Delay discount hyperbolic model param	0.2	0.2	0.3	0.5	0.5	-0.5	0.3
Intermittent access intake day 1-15 change	0.1	0.2	0.7	-0.1	-0.1	0.1	0.8
Intermittent access intake escalation	0.1	0.2	0.9	0.0	-0.0	0.1	1.0
Intermittent access intake escalation 2	0.4	0.4	0.6	0.7	0.6	-0.6	0.6
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.0	0.1	0.2
Intermitt. access day 15 inactive lever presses	1.2	2.4	2.9	1.3	1.5	-1.5	-1.7
Intermitt. access escalation Index	0.3	0.4	0.6	-0.8	-0.6	0.6	0.6
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.5
Intermittent access day 15 total infusions	0.1	0.1	0.1	-0.2	-0.3	0.3	0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.2	0.0	-0.1	0.0
Intermittent access total infusions	0.1	0.1	0.2	0.2	0.0	-0.1	-0.5
Intermittent access day 1 locomotion	0.2	0.3	0.4	-0.6	-0.6	0.5	-0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.3	-0.4	-0.5	0.4	0.4
Intermittent access total locomotion	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1
Intermittent access standard deviation	0.5	1.0	1.5	1.2	1.0	-1.1	-0.5
Left kidney weight	0.1	0.3	1.0	0.1	0.1	-0.3	-1.0
Right kidney weight	0.4	1.8	2.1	1.3	1.3	-1.4	-1.4
Cocaine induced anxiety	0.1	0.1	0.2	0.4	0.3	-0.4	0.2
Post-drug Anxiety	0.4	0.5	0.6	-0.6	-0.8	0.6	0.7
Baseline Anxiety	0.9	1.1	1.5	-1.2	-1.2	1.1	0.5
Tail length	16.0	62.4	87.8	-9.4	-8.8	8.4	3.8
Length with tail	5.8	25.3	40.0	-6.3	-5.7	5.3	0.8
Length without tail	0.5	1.8	5.4	0.5	0.7	-0.9	-2.3
Times rat made contact with spout	0.4	0.5	0.6	-0.8	-0.8	0.7	0.4
Lifetime Intake	0.1	0.1	0.2	0.1	0.1	-0.1	-0.5
Liver weight, left	0.1	0.1	0.3	0.3	0.2	-0.1	0.6
Liver weight, right	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4
Locomotor activity	0.2	0.4	0.8	0.7	0.4	-0.3	0.9
Locomotor testing distance	0.6	1.1	1.7	1.3	1.0	-0.9	1.0
Locomotor testing rearing	0.2	0.5	1.7	0.5	0.2	-0.1	1.3
Locomotion in novel chamber	0.2	0.2	0.4	-0.3	-0.5	0.5	0.6
Locomotion in novel chamber post-restriction	1.0	1.7	2.9	1.7	1.3	-1.4	-0.5
Fecal boli incidents, locomotor time 1	2.9	4.3	5.0	2.0	2.2	-2.2	-1.8
Change in fecal boli incidents, locomotor task	2.1	2.0	2.6	-1.5	-1.6	1.5	0.9
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.7	-0.2	-0.4	0.5	1.3
Bouts of movement, locomotor time 1	0.3	0.3	0.6	0.3	0.4	-0.5	-0.8
Total resting periods, locomotor time 1	0.7	0.8	1.0	0.7	0.8	-0.9	-1.0
Rest time, locomotor task time 1	0.3	0.3	0.4	0.5	0.6	-0.6	-0.5
Distance moved, locomotor task time 1	1.6	2.4	3.2	-1.4	-1.5	1.5	1.8
Vertical activity count, locomotor time 1	0.3	0.8	1.6	-0.6	-0.8	0.9	1.3
Time >=10cm from walls, locomotor time 2	0.3	0.5	0.6	-0.6	-0.7	0.8	0.7
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.2	-0.0	-0.1	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.3	0.0	-0.1	0.5
Rest time, locomotor task time 2	0.4	0.5	0.7	-0.8	-0.7	0.8	0.3
Distance moved, locomotor task time 2	0.1	0.2	0.3	-0.5	-0.4	0.3	-0.3
Vertical activity count, locomotor time 2	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.1
Light reinforcement 1	0.1	0.3	1.0	0.4	0.3	-0.2	1.0
Light reinforcement 2	0.3	0.5	1.2	-0.4	-0.5	0.5	1.1
Bone: marrow area	0.1	0.1	0.2	0.4	0.3	-0.4	-0.3
Bone: maximum diameter	0.4	0.7	1.1	1.0	0.9	-0.9	-0.2
Bone: maximum force	0.5	0.9	1.3	1.1	0.9	-1.0	-0.6
Bone: maximum moment	0.7	1.2	1.6	1.3	1.1	-1.1	-0.8
Mean time between licks in bursts	0.6	1.5	2.2	1.1	1.1	-1.1	-1.5
Mean num. licks in bursts	0.3	0.5	2.0	0.0	0.2	-0.3	-1.4
Cd content in liver	0.3	0.3	1.1	0.1	-0.1	0.2	1.1
Co content in liver	0.0	0.0	0.1	0.1	0.0	0.0	0.4
Cu content in liver	8.2	9.8	10.9	-3.0	-3.3	3.1	3.1
Fe content in liver	0.9	1.1	1.5	-1.0	-1.2	1.1	0.9
K content in liver	0.8	0.8	1.2	-1.0	-1.1	0.7	-0.6
Mg content in liver	4.9	5.0	7.2	-2.5	-2.7	2.3	0.9
Mn content in liver	4.4	4.9	6.9	-2.6	-2.4	2.4	1.2
Na content in liver	0.1	0.1	0.1	-0.2	-0.4	0.0	-0.3
Rb content in liver	1.2	1.4	3.2	-0.7	-1.0	1.1	1.8
Se content in liver	0.2	0.2	0.3	0.6	0.4	-0.4	0.1
Sr content in liver	1.2	1.1	1.9	-1.4	-1.1	1.0	-0.5
Zn content in liver	0.2	0.2	0.4	-0.2	-0.5	0.3	0.6
Bone: minimum diameter	0.1	0.3	0.9	0.2	0.2	-0.4	-0.9
Time in familiar zone, hab. session 1	0.4	0.4	1.2	-0.2	-0.4	0.5	1.1
Time in novel zone, hab. session 1	2.8	2.8	4.0	1.4	1.6	-1.7	-2.0
Total zone transitions, hab. session 1	6.6	9.2	10.2	-3.0	-3.1	3.2	2.8
Total locomotion distance, hab. session 1	4.0	5.7	6.0	-2.3	-2.4	2.5	2.4
Locomotion velocity, hab. session 1	5.1	7.2	7.8	-2.6	-2.8	2.8	2.6
Time in familiar zone, hab. session 2	1.0	1.1	1.5	1.2	1.2	-1.1	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.4	-0.5	0.4	0.2
Total zone transitions, hab. session 2	4.4	5.6	6.2	-2.2	-2.4	2.4	2.5
Total locomotion distance, hab. session 2	0.9	1.2	1.8	-0.9	-1.1	1.0	1.3
Locomotion velocity, hab. session 2	1.0	1.4	1.5	-1.1	-1.2	1.2	1.2
Novel to familiar place preference ratio	0.4	0.4	0.8	-0.4	-0.5	0.6	0.9
Novelty place preference	0.4	0.4	0.7	-0.4	-0.5	0.6	0.9
Time in novel zone, NPP test	0.2	0.3	0.7	-0.2	-0.3	0.4	0.8
Total zone transitions, NPP test	6.0	8.7	9.2	-2.8	-3.0	3.0	3.0
Total locomotion distance, NPP test	2.1	2.9	3.5	-1.5	-1.7	1.7	1.9
Locomotion velocity, NPP test	2.5	3.6	4.0	-1.9	-2.0	2.0	1.7
Intraocular pressure	1.1	1.6	1.9	-1.4	-1.3	1.4	0.9
Delta distance traveled before/after self-admin	1.3	1.4	2.1	1.0	1.2	-1.1	-1.4
Delta ambulatory time before/after self-admin	1.4	1.7	2.1	1.2	1.3	-1.2	-1.5
Parametrial fat weight	0.1	0.2	0.4	0.4	0.4	-0.5	-0.6
Pavlov. Cond. lever latency	1.8	2.3	4.5	1.1	1.2	-1.4	-2.1
Pavlov. Cond. magazine entry latency	0.3	0.4	1.4	-0.2	-0.3	0.4	1.2
Pavlov. Cond. change in total contacts	4.1	4.4	6.0	-1.8	-2.0	2.1	2.4
Pavlov. Cond. index score	1.5	1.8	4.2	-0.8	-1.0	1.2	2.0
Pavlov. Cond. latency score	1.4	1.7	3.7	-0.9	-1.0	1.2	1.9
Pavlov. Cond. lever contacts	3.2	3.9	5.9	-1.6	-1.8	1.9	2.4
Pavlov. Cond. magazine entry number	0.9	1.2	2.4	0.7	0.9	-1.0	-1.6
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.3	-1.0	-1.2	1.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	4.1	-0.8	-1.0	1.2	2.0
Pavlov. Cond. response bias	1.5	1.9	3.9	-0.9	-1.1	1.2	2.0
Pavlov. Cond. lever latency	1.5	2.0	2.7	-1.2	-1.4	1.4	1.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	-0.8	-0.5	0.4	-1.0
Pavlov. Cond. change in total contacts	0.5	0.7	1.5	0.5	0.7	-0.8	-1.2
Pavlov. Cond. index score	0.6	0.8	2.0	0.5	0.7	-0.8	-1.4
Pavlov. Cond. latency score	0.4	0.5	1.6	0.2	0.4	-0.5	-1.3
Pavlov. Cond. lever contacts	1.2	1.7	1.9	1.2	1.3	-1.3	-1.4
Pavlov. Cond. magazine entry number	0.7	0.9	3.3	0.2	-0.1	0.3	1.8
Pavlov. Cond. intertrial magazine entries	1.7	2.6	3.9	-1.3	-1.5	1.6	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.3	0.5	0.7	-0.8	-1.5
Pavlov. Cond. response bias	1.3	1.7	2.4	1.1	1.3	-1.3	-1.6
Time in closed arm before self-admin	2.7	3.4	4.2	2.0	1.9	-2.0	-1.4
Time in closed arm after self-admin	4.3	4.6	6.8	1.9	1.9	-2.0	-2.6
Time in open arm before self-admin	0.5	0.5	0.6	-0.7	-0.8	0.8	0.7
Time in open arm after self-admin	2.6	2.9	3.2	-1.8	-1.7	1.8	1.5
Bone: periosteal estimation	0.3	0.6	1.0	1.0	0.8	-0.9	-0.4
Bone: periosteal perimeter	1.2	2.0	2.6	1.6	1.5	-1.5	-0.9
Bone: post-yield work	0.9	1.3	1.8	1.0	1.1	-1.1	-1.3
Progressive ratio test 1 active lever presses	0.9	1.1	1.3	-1.1	-1.1	1.1	0.8
Progressive ratio test 1 breakpoint	0.7	0.8	0.9	-0.9	-1.0	1.0	0.7
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.6	0.8	0.7	-0.6	-0.2
Progressive ratio test 2 active lever presses	0.5	0.6	0.8	-0.6	-0.9	0.8	0.9
Progressive ratio test 2 breakpoint	0.5	0.6	0.8	-0.6	-0.8	0.8	0.9
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.4	0.1	-0.2	0.1
Incentive Sensitization - Responses	0.1	0.2	0.4	0.1	-0.3	0.2	0.7
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.2	-0.2	0.1	0.6
Sum of active levers in priming session hrs 5-6	3.7	3.5	4.6	-2.1	-1.9	2.0	1.2
Progressive ratio	0.1	0.2	0.6	0.5	0.3	-0.2	0.7
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.2	0.2	-0.1	0.6
Seeking ratio, punishment vs. effort	0.4	0.6	1.1	-1.0	-0.8	0.8	-0.0
Retroperitoneal fat weight	0.3	1.3	2.4	1.5	1.2	-1.2	-0.2
Reaction time number correct	0.7	1.4	2.6	1.0	1.0	-1.0	-1.6
Reaction time mean minus median	0.8	2.1	3.1	-1.8	-1.7	1.5	0.4
Reaction time mean minus median AUC	1.1	2.8	3.8	-2.0	-1.9	1.8	0.8
Reaction time num false alarms	0.8	1.2	1.3	-1.1	-1.0	1.1	1.1
Reaction time num false alarms AUC	0.9	1.4	1.5	-1.2	-1.1	1.2	1.1
Reaction time trials correct on left	0.7	1.4	2.6	1.0	1.0	-1.0	-1.6
Reaction time trials on left	0.7	1.3	2.5	0.9	1.0	-1.0	-1.6
Reaction time mean	0.6	0.9	1.5	-1.2	-1.2	1.0	0.0
Reaction time mean AUC	0.7	1.1	1.7	-1.3	-1.3	1.1	0.1
Median of all reaction times	0.3	0.4	0.6	-0.8	-0.8	0.6	0.0
Reaction time omissions	1.1	1.6	2.1	-1.5	-1.4	1.3	0.7
Reaction time false alarm rate	1.5	2.1	3.0	-1.4	-1.3	1.4	1.7
Reaction time premature initiation rate	0.2	0.3	0.4	-0.6	-0.5	0.6	0.4
Reaction time premature initiations	0.0	0.1	0.2	-0.3	-0.1	0.2	-0.4
Std. dev. reaction times	1.0	1.8	2.9	-1.7	-1.6	1.4	0.1
Reaction time trials completed	0.7	1.3	2.5	0.9	1.0	-1.0	-1.6
Reaction time trials AUC	0.7	1.3	2.5	0.9	1.0	-1.0	-1.6
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.4	-0.2	0.2	-0.5
Run reversals in cocaine runway, males	0.9	0.9	1.8	1.3	1.0	-1.0	0.1
Latency to leave start box in cocaine runway	5.0	5.7	6.3	2.3	2.3	-2.5	-2.4
Latency to leave start box in cocaine runway, F	7.8	8.9	10.2	2.8	2.9	-3.0	-3.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.1	-0.4	0.1
Std. dev. time between licks in bursts	0.8	1.0	1.4	1.2	1.1	-1.1	-0.5
Total sessions with >9 infusions	0.2	0.2	0.8	-0.1	0.1	-0.2	-0.9
Short access day 1 total inactive lever presses	0.5	0.6	0.9	-0.9	-0.9	0.9	0.2
Short access day 10 total inactive lever presses	0.6	1.4	1.8	1.4	1.2	-1.2	-0.9
Short access day 1 total infusions	0.2	0.3	0.9	-0.1	0.1	-0.2	-1.0
Short access day 10 total infusions	0.1	0.2	0.5	0.2	0.2	-0.3	-0.7
Short access total infusions	0.4	0.5	1.3	0.3	0.4	-0.5	-1.1
Short access day 1 locomotion	0.5	0.6	0.8	0.8	0.7	-0.9	-0.7
Short access day 10 total locomotion	0.1	0.1	0.2	0.4	0.3	-0.4	-0.3
Short access total locomotion	0.3	0.4	0.6	0.5	0.6	-0.7	-0.8
One hour access (0.3 mA shock)	0.7	0.8	1.3	-0.7	-0.9	0.9	1.2
Compulsive drug intake	2.9	3.5	3.9	-2.0	-1.8	2.0	1.6
One hour access (shock baseline)	0.6	0.9	1.5	1.2	1.0	-1.0	-0.4
Social response proportion	2.1	2.4	2.9	-1.7	-1.6	1.6	1.2
Social responses	0.2	0.2	0.7	-0.0	-0.0	0.2	0.9
Social time	0.6	0.8	2.7	0.7	0.4	-0.1	1.6
Soleus weight	1.7	5.0	5.3	2.2	2.3	-2.3	-2.2
Bone: stiffness	0.0	0.0	0.1	0.4	0.1	-0.2	-0.2
Tibialis anterior weight	0.1	0.4	0.8	-0.4	-0.3	0.6	0.9
Time to tail flick, vehicle, before self-admin	3.0	3.2	3.4	-1.8	-1.8	1.8	1.7
Time to tail flick, vehicle, after self-admin	0.8	1.1	1.4	1.2	1.0	-1.1	-0.9
Time to tail flick, test, before self-admin	0.7	0.7	1.2	0.7	0.8	-0.8	-1.1
Time to tail flick, test, after self-admin	1.3	1.3	2.6	0.8	1.0	-1.0	-1.6
Delta time to tail flick, vehicle, before/after SA	5.0	4.8	5.8	2.4	2.3	-2.3	-1.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	-0.6	-0.6	0.6	0.5
Tibia length	0.7	2.1	2.7	1.3	1.3	-1.4	-1.6
Ambulatory time before self-admin	1.0	1.5	3.7	-0.6	-0.9	0.9	1.9
Ambulatory time after self-admin	0.1	0.1	0.2	0.4	0.2	-0.2	0.3
Bone: tissue strength	1.1	1.2	1.8	1.0	1.0	-1.0	-1.3
Total heroin consumption	1.2	1.4	2.5	-1.0	-1.0	1.2	1.6
Bone: trabecular number	0.2	0.4	0.6	0.8	0.5	-0.6	0.6
Bone: trabecular spacing	0.1	0.2	0.6	0.1	0.0	0.1	0.8
Bone: trabecular thickness	4.8	6.0	9.3	2.1	2.2	-2.4	-3.0
Bone: trabecular tissue density	0.2	0.3	0.9	-0.3	-0.1	0.1	-1.0
Water consumed over 24 hours	0.0	0.1	0.1	-0.2	-0.2	0.3	0.1
Number of responses in last shaping day	0.9	1.0	1.2	1.1	1.0	-1.0	-0.8