Hub : Genes

Ube2s

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Ube2s	0.09	0.06	1.6e-08	0.04	0.06	0.05	0.05	9.3e-06	1.9e-07	6.5e-06	2.9e-06
2	BLA	mRNA stability	Ube2s	0.08	0.05	7.9e-04	0.02	0.03	0.02	0.02	2.0e-02	1.4e-02	2.0e-02	2.4e-02
3	Brain	mRNA stability	Ube2s	0.02	0.02	3.5e-03	0.01	0.02	0.01	0.01	1.5e-02	4.5e-03	1.2e-02	1.5e-02
4	PL	mRNA stability	Ube2s	0.02	0.02	2.0e-03	0	0	-0	0	1.1e-01	1.1e-01	8.9e-01	2.9e-01
5	Liver	mRNA stability	Ube2s	0.06	0.03	2.5e-07	0.07	0.05	0.06	0.06	6.0e-08	1.1e-06	9.0e-07	1.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	0.4
Area under the delay curve	0.3	0.4	0.5	0.6	0.7	0.7	0.7	-0.7
BMI with tail	0.6	2.0	2.4	1.3	1.3	1.4	1.4	-1.5
BMI without tail	0.0	0.2	0.3	-0.4	-0.5	-0.3	-0.3	0.5
Body weight	1.1	5.0	6.2	-2.5	-2.4	-2.1	-2.1	2.0
Weight adjusted by age	0.3	0.7	1.0	-0.8	-0.7	-1.0	-1.0	0.7
Bone surface	3.0	5.9	6.3	-2.5	-2.5	-2.4	-2.4	2.4
Bone volume	2.4	4.7	4.9	-2.2	-2.2	-2.2	-2.2	2.1
Breakpoint value in progressive ratio session	0.3	0.5	0.7	0.7	0.7	0.7	0.7	-0.8
Number of licking bursts	0.0	0.1	0.1	0.3	0.3	0.3	0.3	-0.3
Context. condit. distance diff. score	0.1	0.2	0.3	0.3	0.6	0.3	0.3	-0.5
Locomotion velocity, session 1	0.1	0.1	0.4	0.4	0.7	-0.1	-0.2	-0.1
Locomotion distance, session 1	2.0	2.6	3.2	-1.5	-1.2	-1.8	-1.8	1.7
Locomotion velocity, session 2	0.1	0.1	0.3	0.5	0.6	0.2	0.1	-0.3
Locomotion distance, session 2	1.8	2.6	3.1	-1.5	-1.4	-1.7	-1.7	1.8
Locomotion velocity, session 3	0.0	0.0	0.1	0.3	0.3	0.2	0.1	-0.2
Locomotion distance, session 3	0.1	0.2	0.2	-0.3	-0.2	-0.5	-0.5	0.4
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.3	0.3	0.4	0.4	-0.5
Stereotopy head waving duration, day 3	0.1	0.2	0.3	0.3	0.3	0.4	0.4	-0.5
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	-0.0	-0.3	-0.3	0.1
Locomotion distance, session 7	0.0	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2
Stereotopy head waving bouts, day 7	0.1	0.2	0.2	-0.4	-0.5	-0.3	-0.3	0.4
Stereotopy head waving duration, day 7	0.1	0.2	0.3	-0.5	-0.5	-0.3	-0.3	0.3
Locomotion velocity, session 8	0.0	0.0	0.2	0.2	0.4	-0.0	-0.1	-0.1
Locomotion distance, session 8	0.1	0.1	0.2	-0.3	-0.1	-0.5	-0.5	0.4
Degree of sensitization distance	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0	-0.1
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.2
Conditioned locomotion	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2	-0.1
Cocaine response after cond. corrected	1.1	1.6	2.1	1.2	0.9	1.4	1.4	-1.2
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.3	-0.6	-0.2	-0.2	0.5
Cocaine response before conditioning	7.7	9.2	10.1	-3.0	-2.8	-3.1	-3.1	3.2
Saline control response	0.0	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.3
Bone: connectivity density	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.2
Bone: cortical apparent density	0.0	0.1	0.1	-0.1	-0.1	-0.3	-0.4	0.1
Bone: cortical area	0.8	1.3	1.5	-1.2	-1.1	-1.1	-1.1	1.0
Bone: cortical porosity	0.5	0.6	0.7	0.8	0.6	0.8	0.8	-0.7
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.1	0.4	0.4	-0.2
Bone: cortical thickness	0.4	0.6	0.7	0.8	0.8	0.7	0.7	-0.9
Bone: cortical thickness	0.1	0.1	0.2	-0.2	-0.2	-0.4	-0.4	0.3
Bone: cortical tissue density	0.0	0.0	0.1	-0.1	-0.0	-0.3	-0.3	0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.5	0.4	0.5	0.5	-0.5
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.2	1.3	1.4	1.5	1.5	-1.5
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.3	0.5
Condit. Reinf. inactive responses	3.3	4.2	4.9	-2.0	-1.9	-2.1	-2.1	2.2
Incentive salience index mean	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.3
Condit. Reinf. lever presses	0.8	1.1	1.2	-1.0	-1.0	-1.1	-1.1	1.0
Condit. Reinf. active minus inactive responses	3.3	5.0	5.3	-2.3	-2.2	-2.3	-2.3	2.1
Condit. Reinf. active-inactive response ratio	4.5	7.2	7.8	-2.7	-2.8	-2.6	-2.6	2.6
Condit. Reinf. active responses	2.8	4.0	4.4	-2.0	-1.8	-2.1	-2.1	1.9
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.0	0.2	-0.0	-0.0	-0.0
Condit. Reinf. lever presses	0.5	0.8	1.1	-1.0	-1.0	-0.7	-0.7	0.9
Condit. Reinf. lever reinforcers received	3.7	5.2	5.7	-2.4	-2.1	-2.4	-2.4	2.2
Conditioned reinforcement - actives	0.1	0.4	0.5	-0.6	-0.7	-0.5	-0.5	0.6
Conditioned reinforcement - inactives	1.4	3.7	3.9	-1.9	-1.9	-2.0	-2.0	1.9
Conditioned locomotion	0.1	0.2	0.2	-0.4	-0.5	-0.3	-0.3	0.4
Patch foraging indifference point 0 sec	0.2	0.6	1.0	0.8	1.0	0.7	0.7	-0.8
Patch foraging indifference point AUC	0.3	0.8	0.9	0.9	0.8	0.9	0.9	-0.8
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.1	0.3	-0.1	-0.1	-0.3
Delay disc. indifference point, 16s delay	0.5	0.7	1.0	0.8	0.6	1.0	1.0	-0.6
Delay disc. indifference point, 2s delay	0.6	0.6	0.8	0.8	0.8	0.7	0.7	-0.9
Delay disc. indifference point, 24s delay	0.4	0.7	0.9	0.8	0.7	0.9	0.9	-0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.2	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	0.4	0.3	0.3	-0.3
Indifference point function ln k	2.5	7.7	8.6	-2.8	-2.6	-2.9	-2.9	2.6
Indifference point function log k	2.5	7.7	8.6	-2.8	-2.6	-2.9	-2.9	2.6
Patch foraging total patch changes 0 sec	0.2	0.6	1.0	0.8	1.0	0.7	0.6	-0.8
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	0.5	0.6	0.6	0.6	-0.4
Patch foraging total patch changes 18 sec	0.4	1.0	1.1	0.9	1.1	1.0	1.0	-1.0
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	0.3
Patch foraging total patch changes 6 sec	0.8	1.4	1.6	1.2	1.3	1.2	1.2	-1.1
Patch foraging time to switch 0 sec	0.8	3.2	4.8	1.6	1.2	2.1	2.2	-1.6
Patch foraging water rate 0 sec	0.2	0.7	1.0	-0.8	-0.5	-1.0	-1.0	0.8
Patch foraging water rate 12 sec	0.7	2.8	3.6	-1.6	-1.3	-1.9	-1.9	1.6
Patch foraging water rate 18 sec	0.5	1.1	1.5	-1.0	-0.8	-1.2	-1.2	1.0
Patch foraging water rate 24 sec	0.7	1.1	1.3	-1.0	-0.8	-1.1	-1.2	1.0
Patch foraging water rate 6 sec	5.9	8.8	8.9	-3.0	-3.0	-2.9	-2.9	3.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.0	0.3	-0.3	-0.3	-0.1
Distance traveled before self-admin	0.8	1.8	2.8	-1.3	-0.9	-1.7	-1.7	1.0
Distance traveled after self-admin	0.3	0.5	1.0	0.7	1.0	0.4	0.4	-0.9
Extensor digitorum longus weight	0.2	0.9	1.2	-1.1	-1.1	-0.9	-0.8	0.7
Bone: elastic displacement	0.4	0.5	0.6	0.7	0.8	0.6	0.6	-0.8
Bone: elastic work	0.4	0.5	0.7	-0.7	-0.6	-0.8	-0.8	0.5
Bone: endosteal estimation	2.8	6.9	8.1	-2.8	-2.7	-2.5	-2.5	2.5
Bone: endosteal perimeter	1.7	4.1	4.9	-2.2	-2.0	-2.0	-1.9	1.9
Epididymis fat weight	0.0	0.1	0.1	-0.2	-0.4	0.2	0.2	0.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.3	0.2	0.2	0.2	0.0
Delta time in open arm before/after self-admin	1.3	1.5	1.9	-1.3	-1.1	-1.4	-1.4	1.1
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.2	-0.0
Delay discount exponential model param	0.2	0.3	0.3	-0.5	-0.6	-0.5	-0.5	0.5
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.3	0.4	0.2	0.2	-0.4
Active lever presses in extinction session 6	0.1	0.1	0.1	0.1	-0.1	0.4	0.4	-0.1
Bone: final force	2.4	4.0	4.2	-2.1	-2.0	-2.0	-2.0	1.9
Bone: final moment	3.0	4.9	5.2	-2.3	-2.2	-2.3	-2.2	2.1
Food consumed during 24 hour testing period	1.3	2.5	2.7	-1.6	-1.5	-1.6	-1.6	1.6
Glucose	1.9	3.0	3.6	1.8	1.9	1.6	1.6	-1.7
Heart weight	1.6	2.5	2.9	-1.6	-1.7	-1.4	-1.4	1.7
Delay discount hyperbolic model param	0.3	0.4	0.4	-0.6	-0.7	-0.6	-0.6	0.6
Intermittent access intake day 1-15 change	0.2	1.1	1.2	-1.1	-1.1	-1.0	-1.0	0.9
Intermittent access intake escalation	0.3	1.7	2.0	-1.4	-1.4	-1.3	-1.3	1.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.3	-0.3	-0.5	-0.5	0.1
Intermitt. access day 1 inactive lever presses	0.2	2.4	2.8	-1.6	-1.7	-1.5	-1.4	1.6
Intermitt. access day 15 inactive lever presses	0.8	4.5	5.3	-2.0	-2.3	-2.0	-2.0	2.3
Intermitt. access escalation Index	0.2	0.6	0.9	0.7	0.8	0.7	0.8	-1.0
Intermittent access day 1 total infusions	0.2	0.7	0.8	-0.9	-0.9	-0.8	-0.8	0.8
Intermittent access day 15 total infusions	0.6	1.4	1.8	-1.3	-1.4	-1.1	-1.1	1.0
Intermittent access terminal intake (last 3 days)	0.7	1.2	1.5	-1.2	-1.2	-1.1	-1.1	0.9
Intermittent access total infusions	1.7	2.0	2.3	-1.5	-1.5	-1.4	-1.4	1.3
Intermittent access day 1 locomotion	0.9	1.6	1.8	-1.3	-1.3	-1.2	-1.2	1.2
Intermittent access day 15 total locomotion	0.4	1.6	2.0	-1.4	-1.2	-1.4	-1.4	1.0
Intermittent access total locomotion	3.2	3.9	4.4	-2.1	-2.0	-2.0	-2.0	1.7
Intermittent access standard deviation	0.1	0.4	0.8	0.5	0.6	0.5	0.5	-0.9
Left kidney weight	3.2	26.0	28.3	-5.3	-5.1	-5.0	-5.0	5.0
Right kidney weight	3.8	26.5	28.7	-5.4	-5.3	-4.9	-4.9	5.3
Cocaine induced anxiety	0.5	1.3	1.3	-1.1	-1.1	-1.1	-1.1	1.1
Post-drug Anxiety	0.5	0.6	0.8	-0.8	-0.9	-0.7	-0.7	0.8
Baseline Anxiety	0.4	0.7	0.8	0.9	0.8	0.9	0.9	-0.9
Tail length	2.6	13.8	14.5	-3.8	-3.8	-3.6	-3.6	3.7
Length with tail	3.1	13.9	15.9	-4.0	-3.9	-3.6	-3.5	3.6
Length without tail	0.9	4.7	6.1	-2.4	-2.5	-1.9	-1.9	2.0
Times rat made contact with spout	0.1	0.1	0.1	0.2	0.2	0.3	0.3	-0.2
Lifetime Intake	1.1	1.4	1.6	-1.2	-1.3	-1.1	-1.1	1.1
Liver weight, left	1.1	1.8	2.0	-1.4	-1.4	-1.3	-1.3	1.4
Liver weight, right	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	0.1
Locomotor activity	0.1	0.1	0.2	0.3	0.3	0.4	0.5	-0.3
Locomotor testing distance	0.0	0.0	0.1	-0.2	-0.3	0.0	0.0	0.2
Locomotor testing rearing	0.2	0.8	1.0	-1.0	-0.9	-0.8	-0.7	1.0
Locomotion in novel chamber	1.5	2.0	2.7	1.3	1.5	1.3	1.3	-1.6
Locomotion in novel chamber post-restriction	0.3	0.8	0.9	0.9	0.9	1.0	1.0	-0.9
Fecal boli incidents, locomotor time 1	0.1	0.3	0.4	-0.6	-0.5	-0.6	-0.6	0.6
Change in fecal boli incidents, locomotor task	3.0	3.2	3.5	1.8	1.8	1.7	1.7	-1.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	0.0	0.2	0.2	-0.1
Bouts of movement, locomotor time 1	0.2	0.3	0.5	-0.4	-0.1	-0.7	-0.7	0.3
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.0	0.3	-0.1	-0.2	-0.1
Rest time, locomotor task time 1	1.1	1.7	1.9	-1.3	-1.3	-1.3	-1.2	1.4
Distance moved, locomotor task time 1	0.7	1.9	2.1	1.4	1.4	1.3	1.3	-1.4
Vertical activity count, locomotor time 1	0.6	4.0	4.8	2.0	2.2	1.8	1.8	-2.2
Time >=10cm from walls, locomotor time 2	0.3	0.9	0.9	1.0	0.8	1.0	1.0	-0.9
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.2	0.2
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2	0.0
Distance moved, locomotor task time 2	0.2	0.2	0.2	0.5	0.4	0.4	0.4	-0.5
Vertical activity count, locomotor time 2	0.1	0.3	0.4	0.5	0.6	0.5	0.5	-0.6
Light reinforcement 1	0.0	0.1	0.2	0.4	0.5	-0.0	-0.1	-0.4
Light reinforcement 2	1.0	2.3	3.3	1.6	1.5	1.3	1.3	-1.8
Bone: marrow area	2.8	7.0	8.1	-2.9	-2.7	-2.5	-2.5	2.5
Bone: maximum diameter	1.0	2.0	2.6	-1.6	-1.5	-1.3	-1.3	1.3
Bone: maximum force	3.0	6.0	6.8	-2.6	-2.5	-2.4	-2.4	2.3
Bone: maximum moment	3.6	6.8	7.6	-2.8	-2.6	-2.6	-2.6	2.4
Mean time between licks in bursts	0.1	0.8	1.0	1.0	1.0	0.7	0.7	-1.0
Mean num. licks in bursts	0.1	0.2	0.2	-0.5	-0.4	-0.3	-0.3	0.4
Cd content in liver	2.3	2.6	2.7	-1.6	-1.5	-1.6	-1.6	1.6
Co content in liver	0.7	0.8	1.4	-0.7	-0.8	-1.1	-1.2	0.6
Cu content in liver	1.0	1.2	1.5	-1.1	-1.2	-1.1	-1.1	1.0
Fe content in liver	0.3	0.4	0.4	-0.6	-0.7	-0.6	-0.6	0.5
K content in liver	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	0.1
Mg content in liver	0.1	0.1	0.1	0.2	0.1	0.3	0.4	-0.2
Mn content in liver	0.0	0.0	0.0	0.1	-0.0	0.2	0.2	-0.1
Na content in liver	3.1	3.5	3.8	2.0	1.9	1.9	1.8	-1.9
Rb content in liver	3.0	3.5	4.1	-1.8	-2.0	-1.7	-1.7	2.0
Se content in liver	2.4	2.8	3.2	1.5	1.5	1.8	1.8	-1.8
Sr content in liver	6.6	5.7	7.0	2.5	2.6	2.1	2.1	-2.6
Zn content in liver	0.3	0.4	0.7	0.6	0.4	0.8	0.8	-0.4
Bone: minimum diameter	3.4	6.5	7.2	-2.7	-2.5	-2.5	-2.5	2.6
Time in familiar zone, hab. session 1	2.8	3.1	3.8	-1.8	-1.5	-1.9	-1.9	1.5
Time in novel zone, hab. session 1	2.5	2.8	3.2	1.8	1.5	1.7	1.7	-1.6
Total zone transitions, hab. session 1	0.5	0.8	1.2	-0.6	-0.5	-1.1	-1.1	0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.2	-0.1	-0.6	-0.6	0.4
Locomotion velocity, hab. session 1	0.1	0.2	0.3	-0.2	-0.1	-0.5	-0.5	0.4
Time in familiar zone, hab. session 2	3.1	3.5	4.1	-2.0	-2.0	-1.7	-1.7	1.9
Time in novel zone, hab. session 2	2.0	2.2	2.6	1.6	1.5	1.4	1.4	-1.6
Total zone transitions, hab. session 2	2.1	2.7	3.2	-1.6	-1.3	-1.7	-1.8	1.8
Total locomotion distance, hab. session 2	0.0	0.0	0.1	-0.0	0.2	-0.2	-0.2	0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	0.4	-0.1	-0.1	0.0
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.1	0.1
Novelty place preference	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.3
Time in novel zone, NPP test	0.1	0.2	0.2	-0.5	-0.4	-0.4	-0.3	0.4
Total zone transitions, NPP test	0.2	0.4	0.6	-0.5	-0.3	-0.6	-0.6	0.8
Total locomotion distance, NPP test	0.3	0.4	0.7	-0.6	-0.5	-0.6	-0.6	0.9
Locomotion velocity, NPP test	0.3	0.5	0.8	-0.6	-0.5	-0.7	-0.7	0.9
Intraocular pressure	0.0	0.0	0.1	0.3	0.2	0.1	0.1	-0.3
Delta distance traveled before/after self-admin	2.4	2.6	2.8	1.6	1.6	1.7	1.7	-1.6
Delta ambulatory time before/after self-admin	1.1	1.9	2.0	1.4	1.4	1.4	1.4	-1.3
Parametrial fat weight	1.9	4.4	4.8	2.0	2.1	2.2	2.2	-2.0
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.4	0.3	0.3	0.3	-0.5
Pavlov. Cond. magazine entry latency	0.6	0.8	1.0	0.9	0.7	1.0	1.0	-0.7
Pavlov. Cond. change in total contacts	0.3	0.3	0.3	0.5	0.6	0.5	0.5	-0.5
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	0.6	0.6	0.6	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.3	0.4	0.5	0.5	0.5	-0.3
Pavlov. Cond. lever contacts	0.1	0.2	0.3	-0.5	-0.4	-0.2	-0.2	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.5	-0.4	-0.6	-0.6	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.3	0.6	0.0	-0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	0.6	0.6	0.6	0.6	-0.5
Pavlov. Cond. response bias	0.0	0.0	0.0	0.0	-0.1	0.2	0.2	0.1
Pavlov. Cond. lever latency	0.3	0.5	0.6	-0.7	-0.6	-0.6	-0.6	0.8
Pavlov. Cond. magazine entry latency	0.7	1.0	1.1	1.0	0.9	1.1	1.1	-1.1
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.3	-0.3	-0.4	-0.4	-0.0
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	0.2	0.3	0.3	-0.4
Pavlov. Cond. latency score	0.3	0.5	0.7	0.7	0.6	0.7	0.7	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	0.2	0.3	0.3	-0.5
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.8	-0.7	-0.8	-0.8	0.9
Pavlov. Cond. intertrial magazine entries	2.3	4.9	5.1	-2.2	-2.2	-2.2	-2.2	2.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.4	0.3	0.4	0.4	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.3	0.2
Time in closed arm before self-admin	0.6	1.0	1.1	-1.0	-1.0	-1.0	-1.0	0.9
Time in closed arm after self-admin	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.2	0.5
Time in open arm before self-admin	2.0	2.4	2.6	1.6	1.6	1.6	1.6	-1.4
Time in open arm after self-admin	0.2	0.2	0.4	0.4	0.6	0.3	0.3	-0.6
Bone: periosteal estimation	2.1	5.0	5.9	-2.4	-2.3	-2.2	-2.2	2.1
Bone: periosteal perimeter	1.6	3.2	3.7	-1.9	-1.8	-1.8	-1.8	1.6
Bone: post-yield work	2.9	5.1	5.9	-2.4	-2.4	-2.1	-2.1	2.2
Progressive ratio test 1 active lever presses	0.5	0.9	1.2	-0.9	-0.8	-1.1	-1.1	0.8
Progressive ratio test 1 breakpoint	0.5	0.9	1.2	-0.9	-0.8	-1.1	-1.1	0.8
Progressive ratio test 1 inactive lever presses	1.7	4.4	4.6	-2.0	-2.1	-2.1	-2.1	2.1
Progressive ratio test 2 active lever presses	0.5	0.8	1.1	-0.9	-1.0	-0.8	-0.8	0.8
Progressive ratio test 2 breakpoint	0.7	0.9	1.3	-1.0	-1.1	-0.9	-0.9	0.9
Progressive ratio test 2 inactive lever presses	1.6	5.1	5.2	-2.3	-2.3	-2.3	-2.2	2.2
Incentive Sensitization - Responses	0.7	2.0	2.8	-1.6	-1.7	-1.3	-1.2	1.4
Incentive Sensitization - Breakpoint	0.6	1.4	2.0	-1.3	-1.4	-1.0	-1.0	1.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	0.3	0.1	0.1	-0.3
Progressive ratio	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.1	0.6	-0.6	-0.6	-0.1
Seeking ratio, punishment vs. effort	0.2	0.5	0.7	-0.7	-0.5	-0.8	-0.9	0.5
Retroperitoneal fat weight	4.1	18.2	20.5	4.1	4.0	4.5	4.5	-4.2
Reaction time number correct	0.1	0.2	0.3	0.5	0.6	0.4	0.4	-0.6
Reaction time mean minus median	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.1
Reaction time mean minus median AUC	0.0	0.0	0.0	0.0	0.0	0.1	0.1	-0.0
Reaction time num false alarms	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.2
Reaction time num false alarms AUC	0.1	0.2	0.5	0.5	0.5	0.3	0.3	-0.7
Reaction time trials correct on left	0.1	0.2	0.3	0.5	0.6	0.4	0.4	-0.6
Reaction time trials on left	0.1	0.2	0.3	0.5	0.6	0.4	0.4	-0.6
Reaction time mean	0.5	1.1	1.5	-1.0	-1.2	-1.0	-1.0	1.1
Reaction time mean AUC	0.2	0.4	0.7	-0.6	-0.8	-0.5	-0.5	0.7
Median of all reaction times	0.7	1.1	1.5	-1.0	-1.2	-0.9	-0.9	1.1
Reaction time omissions	0.0	0.1	0.1	0.3	0.3	0.0	0.0	-0.4
Reaction time false alarm rate	0.0	0.0	0.1	0.2	0.2	0.1	0.0	-0.4
Reaction time premature initiation rate	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.0	0.3
Reaction time premature initiations	0.0	0.0	0.1	0.1	0.2	0.3	0.3	-0.1
Std. dev. reaction times	0.2	0.7	0.9	-0.8	-0.9	-0.8	-0.7	0.9
Reaction time trials completed	0.1	0.2	0.3	0.5	0.6	0.4	0.4	-0.6
Reaction time trials AUC	0.1	0.2	0.2	0.4	0.5	0.4	0.4	-0.5
Run reversals in cocaine runway, females	0.4	0.4	0.6	-0.6	-0.8	-0.5	-0.5	0.8
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1	-0.0
Latency to leave start box in cocaine runway	0.5	0.7	0.8	-0.8	-0.9	-0.8	-0.8	0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.3
Latency to leave start box in cocaine runway, M	1.6	1.5	1.7	-1.2	-1.3	-1.2	-1.2	1.1
Std. dev. time between licks in bursts	0.1	0.2	0.4	0.5	0.6	0.1	0.0	-0.5
Total sessions with >9 infusions	1.0	1.2	1.4	-1.1	-1.0	-1.2	-1.2	1.0
Short access day 1 total inactive lever presses	0.5	1.0	1.4	-1.1	-1.2	-0.9	-0.9	1.0
Short access day 10 total inactive lever presses	0.0	0.2	0.3	-0.5	-0.5	-0.4	-0.4	0.4
Short access day 1 total infusions	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1
Short access day 10 total infusions	0.0	0.0	0.0	0.1	0.1	0.1	0.0	-0.1
Short access total infusions	0.0	0.0	0.0	0.2	0.2	0.1	0.1	-0.2
Short access day 1 locomotion	0.3	0.5	0.6	-0.8	-0.8	-0.7	-0.6	0.7
Short access day 10 total locomotion	0.2	0.8	1.1	-0.9	-0.6	-1.1	-1.1	0.7
Short access total locomotion	0.1	0.2	0.4	-0.4	-0.2	-0.6	-0.7	0.2
One hour access (0.3 mA shock)	4.5	5.3	5.8	-2.4	-2.4	-2.3	-2.3	2.2
Compulsive drug intake	1.6	2.3	2.6	-1.6	-1.6	-1.5	-1.5	1.4
One hour access (shock baseline)	0.2	0.5	0.8	-0.7	-0.9	-0.6	-0.6	0.8
Social response proportion	0.9	1.1	1.5	-1.0	-1.2	-0.9	-0.9	1.2
Social responses	3.4	4.4	4.9	-2.0	-2.2	-2.0	-2.0	2.2
Social time	3.0	4.7	5.3	-2.1	-1.8	-2.3	-2.3	2.3
Soleus weight	0.0	0.1	0.2	-0.5	-0.3	-0.3	-0.3	0.1
Bone: stiffness	2.7	4.8	5.2	-2.3	-2.3	-2.2	-2.2	2.1
Tibialis anterior weight	0.8	2.8	3.5	1.4	1.5	1.8	1.8	-1.9
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.5	-0.6	-0.5	-0.7	-0.7	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.6	-0.7	-0.8	-0.5	-0.5	0.6
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.4	0.7	0.2	0.1	-0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.2	0.4	0.3	0.5	0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.2	0.0	0.4	0.4	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.3	-0.6	-0.2	-0.2	0.7
Tibia length	4.0	11.2	12.4	-3.5	-3.4	-3.2	-3.2	3.5
Ambulatory time before self-admin	0.5	1.6	2.4	-1.2	-0.9	-1.5	-1.6	1.0
Ambulatory time after self-admin	0.0	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.2
Bone: tissue strength	0.1	0.1	0.2	-0.3	-0.0	-0.5	-0.5	0.2
Total heroin consumption	0.0	0.0	0.1	0.1	0.2	0.1	0.1	-0.3
Bone: trabecular number	0.1	0.2	0.3	0.5	0.5	0.4	0.4	-0.4
Bone: trabecular spacing	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1	0.0
Bone: trabecular thickness	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.0
Bone: trabecular tissue density	0.5	0.9	1.2	0.9	0.8	1.1	1.1	-0.8
Water consumed over 24 hours	0.6	1.2	1.4	-1.1	-0.9	-1.2	-1.2	1.1
Number of responses in last shaping day	0.0	0.0	0.1	-0.1	-0.2	-0.0	-0.0	0.3