Hub : Genes

Ube2n

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Ube2n 0.27 0.11 1.7e-03 -0.01 0.06 0.04 0.01 9.0e-01 1.3e-02 3.9e-02 1.7e-01
2 LHb gene expression Ube2n 0.22 0.11 2.7e-03 0.01 0.07 0.03 0.02 2.2e-01 9.8e-03 7.0e-02 9.6e-02
3 OFC mRNA stability Ube2n 0.26 0.12 2.8e-03 0.06 0.07 0.11 0.09 1.3e-02 7.9e-03 1.7e-03 4.2e-03
4 pVTA gene expression Ube2n 0.13 0.06 2.3e-07 0.07 0.08 0.07 0.07 1.7e-06 9.7e-07 2.0e-06 1.8e-06
5 Liver gene expression Ube2n 0.06 0.03 1.1e-05 0 0.03 0.02 0.01 1.5e-01 1.3e-04 1.8e-03 6.6e-02
6 Brain gene expression Ube2n 0.12 0.05 1.1e-07 0.07 0.07 0.07 0.07 6.2e-07 7.2e-07 4.2e-07 7.3e-07
7 BLA gene expression Ube2n 0.17 0.06 1.1e-06 0.12 0.12 0.11 0.11 7.3e-07 9.3e-07 2.0e-06 1.6e-06
8 PL gene expression Ube2n 0.14 0.05 1.1e-16 0.17 0.13 0.16 0.16 2.9e-18 4.3e-14 5.8e-17 9.3e-17
9 IC gene expression Ube2n 0.24 0.09 9.8e-06 0.17 0.12 0.11 0.15 1.3e-07 1.4e-05 1.7e-05 5.4e-07
10 NAcc gene expression Ube2n 0.06 0.03 2.0e-06 0.05 0.04 0.03 0.04 1.1e-07 4.9e-07 5.3e-06 3.2e-07
11 Adipose mRNA stability Ube2n 0.16 0.06 6.8e-08 0.04 0.06 0.07 0.05 2.2e-05 1.1e-07 3.2e-08 1.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.51.90.2-0.61.10.71.41.2-0.3-0.1-0.3-0.1-0.5
Area under the delay curve0.91.14.60.1-0.31.3-0.32.2-0.2-1.0-0.9-0.9-1.0-1.3
BMI with tail0.72.49.72.41.50.3-1.60.5-3.1-0.7-0.4-0.8-0.4-2.2
BMI without tail0.51.66.72.61.1-1.5-1.3-1.8-1.7-0.00.2-0.10.1-0.1
Body weight1.04.531.25.62.3-0.6-2.2-1.1-2.6-0.2-0.0-0.2-0.0-0.1
Weight adjusted by age1.21.92.91.01.40.51.5-0.21.71.71.61.71.71.1
Bone surface0.30.51.31.20.50.50.31.10.80.70.60.70.60.1
Bone volume0.20.41.21.00.20.70.41.10.70.40.40.40.4-0.2
Breakpoint value in progressive ratio session0.81.02.2-0.20.80.61.41.30.21.01.21.01.01.5
Number of licking bursts0.20.41.01.00.60.60.01.0-0.10.40.20.30.2-1.0
Context. condit. distance diff. score0.50.51.3-0.3-0.7-0.7-0.9-0.5-1.1-0.7-0.7-0.7-0.8-0.6
Locomotion velocity, session 10.70.81.9-0.20.50.81.30.61.40.80.90.90.90.6
Locomotion distance, session 10.30.30.80.20.70.80.30.90.90.30.40.30.40.4
Locomotion velocity, session 20.50.61.8-1.1-1.0-1.3-0.0-0.70.4-0.4-0.2-0.4-0.31.3
Locomotion distance, session 20.81.12.11.31.21.30.61.41.20.90.70.90.81.0
Locomotion velocity, session 30.40.41.9-0.5-0.50.20.8-0.21.10.00.00.10.11.4
Locomotion distance, session 30.30.31.40.40.11.2-0.50.5-0.1-0.5-0.4-0.5-0.4-0.5
Stereotopy head waving bouts, day 32.63.18.20.20.5-0.12.3-0.22.91.91.72.01.72.6
Stereotopy head waving duration, day 31.51.84.7-0.20.1-0.81.8-0.82.01.41.11.41.22.2
Locomotion velocity, session 70.91.02.40.70.81.51.21.31.30.40.80.50.81.0
Locomotion distance, session 70.50.62.7-0.3-0.41.4-0.31.60.4-0.6-0.6-0.6-0.7-0.2
Stereotopy head waving bouts, day 70.20.21.1-0.4-0.60.10.3-0.51.1-0.4-0.2-0.4-0.10.2
Stereotopy head waving duration, day 70.10.10.4-0.3-0.30.00.1-0.70.5-0.4-0.2-0.4-0.2-0.1
Locomotion velocity, session 80.70.84.5-0.6-0.4-1.7-0.3-2.1-0.5-0.1-0.1-0.1-0.10.9
Locomotion distance, session 80.60.93.51.91.21.00.40.90.30.80.70.80.71.0
Degree of sensitization distance0.10.10.4-0.6-0.3-0.50.10.60.10.10.00.1-0.10.6
Degree of sensitization stereotypy0.80.91.7-1.1-1.1-0.3-0.8-0.6-0.1-1.3-1.1-1.3-1.0-0.7
Conditioned locomotion0.60.71.4-0.7-1.1-0.7-0.40.9-0.2-1.1-0.8-1.2-0.90.2
Cocaine response after cond. corrected0.30.41.00.1-0.4-1.0-0.9-0.5-0.7-0.7-0.3-0.6-0.4-0.7
Cocaine response after cond. not corrected0.10.20.50.4-0.1-0.4-0.5-0.0-0.6-0.4-0.2-0.4-0.2-0.7
Cocaine response before conditioning0.30.40.80.50.70.80.60.30.20.90.50.80.60.1
Saline control response0.10.10.50.50.1-0.20.1-0.40.7-0.10.2-0.10.20.5
Bone: connectivity density0.60.95.00.0-0.2-0.41.20.32.20.71.00.60.91.0
Bone: cortical apparent density0.20.20.4-0.2-0.5-0.0-0.40.60.5-0.5-0.5-0.4-0.50.6
Bone: cortical area0.50.82.21.20.11.2-0.61.5-0.7-0.6-0.7-0.6-0.5-1.3
Bone: cortical porosity0.30.31.2-0.2-0.3-1.00.1-0.90.1-0.2-0.0-0.1-0.11.1
Bone: cortical porosity0.10.11.00.20.1-0.40.2-0.50.10.10.20.10.21.0
Bone: cortical thickness0.40.71.20.3-0.60.6-0.61.1-0.2-1.0-1.1-1.0-1.0-1.0
Bone: cortical thickness0.30.40.6-0.7-0.7-0.3-0.60.1-0.7-0.8-0.8-0.7-0.8-0.5
Bone: cortical tissue density0.20.20.5-0.2-0.6-0.1-0.40.60.5-0.4-0.4-0.4-0.40.7
Condit. Reinf. active minus inactive responses1.11.33.60.31.11.91.71.20.70.91.10.91.10.3
Condit. Reinf. active-inactive response ratio1.01.14.10.51.12.01.41.30.20.50.90.40.9-0.4
Condit. Reinf. active responses1.01.33.20.11.01.81.80.90.91.11.11.11.20.1
Condit. Reinf. inactive responses0.10.10.8-0.9-0.10.00.2-0.30.30.50.10.60.10.1
Incentive salience index mean3.13.87.81.52.02.82.71.71.71.91.91.92.00.5
Condit. Reinf. lever presses2.53.56.61.71.92.62.31.32.11.91.71.91.80.4
Condit. Reinf. active minus inactive responses0.20.30.6-0.40.70.70.4-0.30.70.20.40.40.40.8
Condit. Reinf. active-inactive response ratio0.20.21.3-0.7-0.10.3-0.3-1.10.0-0.3-0.4-0.2-0.4-0.1
Condit. Reinf. active responses0.10.10.4-0.50.60.3-0.1-0.00.30.10.30.20.20.5
Condit. Reinf. inactive responses0.10.20.7-0.80.2-0.9-0.50.5-0.4-0.00.00.00.00.2
Condit. Reinf. lever presses0.81.13.6-0.11.2-0.40.4-1.50.70.91.20.91.11.9
Condit. Reinf. lever reinforcers received0.10.10.4-0.60.50.5-0.40.2-0.1-0.2-0.0-0.1-0.10.2
Conditioned reinforcement - actives1.32.34.21.31.10.31.8-0.02.02.01.41.91.31.8
Conditioned reinforcement - inactives1.52.26.30.90.60.02.10.91.81.71.41.61.32.5
Conditioned locomotion0.10.10.50.70.10.20.20.40.40.30.00.4-0.10.7
Patch foraging indifference point 0 sec0.40.81.3-0.5-1.10.0-0.8-0.10.4-1.1-1.1-1.0-1.1-1.0
Patch foraging indifference point AUC0.20.30.70.60.20.80.60.10.80.70.30.70.30.2
Delay disc. indifference point, 0s delay0.60.61.20.50.81.01.10.91.10.60.70.60.60.6
Delay disc. indifference point, 16s delay1.92.16.90.1-0.61.2-0.92.6-1.0-1.5-1.5-1.5-1.5-1.9
Delay disc. indifference point, 2s delay0.30.30.60.80.80.50.60.60.50.40.60.50.50.1
Delay disc. indifference point, 24s delay0.91.02.1-0.3-1.00.1-0.81.2-0.4-1.3-1.4-1.3-1.3-0.9
Delay disc. indifference point, 4s delay0.40.41.4-0.2-0.30.1-0.70.3-0.8-0.6-0.8-0.6-0.8-1.2
Delay disc. indifference point, 8s delay1.61.93.3-0.8-1.10.7-1.21.6-0.6-1.6-1.6-1.6-1.7-1.8
Indifference point function ln k0.51.02.8-0.5-0.5-1.1-1.2-0.0-1.7-1.1-0.8-1.2-0.8-0.6
Indifference point function log k0.51.02.8-0.5-0.5-1.1-1.2-0.0-1.7-1.1-0.8-1.2-0.8-0.6
Patch foraging total patch changes 0 sec0.40.71.3-0.5-1.1-0.2-0.8-0.10.3-1.1-1.1-1.1-1.1-0.8
Patch foraging total patch changes 12 sec0.70.93.31.20.71.70.8-0.11.80.50.70.60.5-0.5
Patch foraging total patch changes 18 sec0.20.30.70.4-0.60.6-0.2-0.60.6-0.3-0.4-0.2-0.4-0.8
Patch foraging total patch changes 24 sec0.20.31.30.5-0.40.4-0.5-1.1-0.1-0.5-0.6-0.4-0.5-0.8
Patch foraging total patch changes 6 sec0.50.82.9-0.4-0.70.2-1.0-0.7-0.3-0.9-1.1-0.9-1.0-1.7
Patch foraging time to switch 0 sec0.10.21.10.10.30.40.50.11.00.30.40.40.50.5
Patch foraging water rate 0 sec0.51.14.72.21.51.30.30.8-0.60.70.70.60.4-1.1
Patch foraging water rate 12 sec0.20.42.21.50.6-0.20.0-0.6-0.10.10.10.1-0.0-1.0
Patch foraging water rate 18 sec0.40.71.71.11.3-0.30.7-0.5-0.30.81.20.70.90.4
Patch foraging water rate 24 sec0.81.16.32.51.61.00.40.4-0.50.80.90.60.6-0.2
Patch foraging water rate 6 sec2.53.613.03.62.80.51.2-0.50.32.02.11.92.10.7
Seeking ratio, delayed vs. immediate footshock0.70.92.40.60.31.61.51.01.40.40.60.40.50.7
Distance traveled before self-admin1.11.52.41.31.50.71.40.20.91.41.31.41.41.1
Distance traveled after self-admin0.50.63.50.40.21.50.61.9-0.30.0-0.1-0.1-0.30.7
Extensor digitorum longus weight0.10.31.00.70.4-1.0-0.5-0.5-0.90.10.10.10.00.3
Bone: elastic displacement0.70.84.1-2.0-0.6-1.0-0.0-1.3-1.1-0.2-0.3-0.2-0.3-0.3
Bone: elastic work1.92.45.5-2.3-1.8-0.6-1.1-0.5-1.5-1.8-1.8-1.8-1.7-1.2
Bone: endosteal estimation0.30.72.00.90.41.2-0.61.4-1.30.00.0-0.00.1-0.9
Bone: endosteal perimeter0.71.45.22.31.21.4-0.61.5-1.60.30.30.30.4-1.3
Epididymis fat weight1.03.412.13.53.20.90.2-0.8-0.31.72.01.62.0-0.0
Delta time in closed arm before/after self-admin0.20.20.80.50.7-0.0-0.5-0.7-0.90.20.30.20.30.0
Delta time in open arm before/after self-admin0.50.51.9-1.4-1.00.40.00.40.2-0.6-0.8-0.4-0.6-0.6
Diff in mean of infusions in LGA sessions0.10.10.3-0.60.20.60.40.3-0.10.10.20.20.20.1
Delay discount exponential model param0.91.03.30.00.5-0.90.5-1.80.41.01.01.01.11.3
Extinction: sum of active levers before priming0.40.51.0-0.8-0.7-0.2-0.50.4-0.7-1.0-0.8-0.9-0.7-0.4
Active lever presses in extinction session 61.91.93.51.11.51.91.41.60.91.61.21.51.40.8
Bone: final force2.23.58.60.1-1.22.0-1.32.9-1.4-1.9-2.0-1.9-2.0-2.5
Bone: final moment2.03.28.90.2-1.12.1-1.13.0-1.0-1.7-1.9-1.7-1.8-2.4
Food consumed during 24 hour testing period1.21.64.0-0.5-1.0-1.4-1.6-1.5-2.0-1.1-1.0-1.3-1.0-0.9
Glucose0.10.10.6-0.2-0.10.0-0.2-0.2-0.8-0.1-0.2-0.2-0.2-0.2
Heart weight2.53.89.13.02.32.31.32.51.11.61.71.61.91.3
Delay discount hyperbolic model param0.70.83.0-0.20.2-1.00.3-1.70.30.80.80.80.81.1
Intermittent access intake day 1-15 change0.81.63.21.81.80.20.6-0.50.71.71.51.71.00.4
Intermittent access intake escalation0.71.53.41.71.80.20.7-0.70.71.71.51.71.00.3
Intermittent access intake escalation 21.01.12.51.61.40.20.6-0.40.51.51.31.60.80.4
Intermitt. access day 1 inactive lever presses0.31.23.8-2.0-1.8-0.10.10.8-0.4-1.1-1.2-1.0-0.80.8
Intermitt. access day 15 inactive lever presses0.20.51.1-1.0-1.0-0.8-0.10.0-0.8-0.5-0.6-0.4-0.61.0
Intermitt. access escalation Index0.40.51.5-0.50.4-0.80.5-1.20.70.60.80.70.80.3
Intermittent access day 1 total infusions1.52.46.8-0.7-1.4-2.6-2.3-1.5-1.3-1.0-1.6-1.2-1.6-0.8
Intermittent access day 15 total infusions0.60.94.30.70.2-2.1-1.1-1.8-0.40.5-0.20.3-0.50.0
Intermittent access terminal intake (last 3 days)0.60.83.40.60.2-1.9-1.2-1.4-0.80.3-0.20.2-0.60.0
Intermittent access total infusions1.21.43.7-0.1-0.7-1.8-1.9-1.3-1.4-0.7-1.2-0.8-1.3-0.5
Intermittent access day 1 locomotion3.24.17.3-1.4-2.5-2.4-2.7-0.9-1.5-1.9-2.5-2.0-2.5-0.9
Intermittent access day 15 total locomotion1.12.05.1-0.9-2.3-1.8-1.7-0.7-0.6-1.5-1.5-1.4-1.80.1
Intermittent access total locomotion2.02.44.6-0.8-1.9-2.2-2.1-1.3-1.2-1.4-1.6-1.5-1.8-0.1
Intermittent access standard deviation0.30.62.91.71.00.0-0.2-0.10.51.10.61.10.0-0.4
Left kidney weight0.41.79.13.01.5-0.3-1.2-1.8-1.40.50.20.50.30.1
Right kidney weight0.52.112.63.62.30.6-0.6-0.7-1.10.80.80.81.0-0.0
Cocaine induced anxiety0.30.52.4-1.1-0.60.60.41.6-0.40.2-0.40.5-0.3-0.3
Post-drug Anxiety0.30.31.2-1.1-0.2-0.20.70.30.20.70.20.90.3-0.0
Baseline Anxiety0.40.43.00.40.4-0.80.1-1.70.40.20.30.10.30.4
Tail length0.83.313.63.0-0.2-2.6-1.4-3.7-0.1-0.3-0.2-0.3-0.22.1
Length with tail0.93.822.54.71.1-1.7-1.6-3.0-0.1-0.00.10.10.12.0
Length without tail0.41.410.43.21.00.0-1.4-0.3-0.7-0.5-0.3-0.5-0.30.4
Times rat made contact with spout0.80.94.41.50.31.4-0.11.00.1-0.5-0.3-0.6-0.3-2.1
Lifetime Intake0.91.13.30.1-0.5-1.5-1.8-0.9-1.1-0.6-1.1-0.7-1.2-1.0
Liver weight, left2.23.613.33.62.20.41.4-1.21.21.92.11.82.00.9
Liver weight, right1.12.05.02.21.4-0.90.5-1.90.51.41.31.41.41.6
Locomotor activity1.72.79.83.12.32.00.91.60.81.21.41.11.20.5
Locomotor testing distance1.42.67.82.82.32.40.81.70.21.21.11.31.2-0.4
Locomotor testing rearing1.22.35.72.42.01.91.30.80.61.71.31.71.60.0
Locomotion in novel chamber0.60.82.40.60.31.41.51.21.40.20.50.20.50.6
Locomotion in novel chamber post-restriction0.30.63.4-0.0-0.2-1.9-0.2-1.10.50.60.40.60.40.3
Fecal boli incidents, locomotor time 10.10.10.60.1-0.3-0.2-0.1-0.10.8-0.00.10.10.10.2
Change in fecal boli incidents, locomotor task1.61.63.8-1.0-0.90.9-0.72.0-1.6-1.1-1.4-1.0-1.4-1.3
Time >=10cm from walls, locomotor time 10.20.20.8-0.40.30.2-0.6-0.4-0.9-0.3-0.2-0.1-0.3-0.4
Bouts of movement, locomotor time 10.30.40.80.50.50.20.40.90.60.80.50.90.50.5
Total resting periods, locomotor time 10.20.30.60.20.30.00.40.80.60.70.40.70.30.7
Rest time, locomotor task time 10.20.20.4-0.7-0.10.10.4-0.40.60.60.30.70.10.4
Distance moved, locomotor task time 10.91.33.31.81.71.51.30.30.70.61.20.51.20.3
Vertical activity count, locomotor time 10.51.13.92.01.71.30.80.90.10.60.70.50.90.1
Time >=10cm from walls, locomotor time 20.40.52.4-0.8-0.30.9-0.1-0.50.6-0.6-0.5-0.6-0.6-1.6
Bouts of movement, locomotor time 20.30.51.00.70.8-0.50.10.0-0.00.80.71.00.70.9
Total resting periods, locomotor time 20.10.30.70.60.7-0.1-0.00.3-0.20.60.60.80.50.5
Rest time, locomotor task time 20.10.20.9-0.50.3-0.1-0.30.1-1.00.20.10.50.10.1
Distance moved, locomotor task time 20.81.01.71.01.10.41.2-1.21.30.91.10.61.10.7
Vertical activity count, locomotor time 21.21.74.62.11.71.11.2-0.41.61.11.20.81.30.7
Light reinforcement 10.20.51.20.70.8-0.30.4-0.3-0.11.11.01.01.00.4
Light reinforcement 20.30.41.3-0.7-0.8-1.2-0.9-0.2-0.6-0.3-0.6-0.4-0.4-0.4
Bone: marrow area0.30.72.00.80.41.2-0.71.3-1.4-0.0-0.0-0.00.0-1.0
Bone: maximum diameter0.61.13.51.90.70.8-0.71.7-1.3-0.1-0.1-0.2-0.0-1.3
Bone: maximum force1.22.13.6-0.2-1.01.4-1.41.9-1.4-1.5-1.7-1.5-1.6-1.7
Bone: maximum moment1.12.04.1-0.3-0.91.5-1.22.0-1.0-1.5-1.6-1.4-1.5-1.7
Mean time between licks in bursts0.20.42.20.81.50.2-0.0-0.1-0.10.40.60.60.60.2
Mean num. licks in bursts0.10.20.5-0.2-0.40.5-0.0-0.00.1-0.7-0.3-0.6-0.3-0.5
Cd content in liver0.30.41.6-0.3-0.30.6-0.61.3-0.5-0.7-0.6-0.5-0.6-0.2
Co content in liver0.70.81.61.11.10.11.0-0.30.70.71.30.91.30.9
Cu content in liver0.60.82.60.10.1-1.40.4-1.30.30.70.50.80.51.6
Fe content in liver0.60.72.30.1-0.70.6-0.91.5-0.6-0.7-1.2-0.6-1.2-0.5
K content in liver2.52.48.9-0.5-0.4-1.91.4-1.93.01.00.90.90.92.2
Mg content in liver2.22.27.40.10.5-0.61.7-0.72.71.61.41.71.42.0
Mn content in liver0.30.41.40.30.5-0.10.40.10.61.00.51.20.50.5
Na content in liver1.01.12.0-1.3-1.4-1.4-1.0-0.8-0.1-0.7-1.3-0.8-1.3-0.7
Rb content in liver0.80.92.7-1.3-1.5-1.6-0.2-1.00.3-0.6-0.7-0.6-0.70.6
Se content in liver0.10.10.4-0.2-0.00.6-0.40.3-0.1-0.1-0.30.1-0.30.4
Sr content in liver1.81.64.01.10.72.01.81.01.61.01.11.21.10.1
Zn content in liver0.80.93.90.30.1-1.9-0.2-2.00.40.10.20.20.21.4
Bone: minimum diameter1.32.44.82.10.62.1-1.32.2-1.8-0.9-0.8-0.9-0.8-2.2
Time in familiar zone, hab. session 10.10.10.4-0.5-0.1-0.6-0.3-0.1-0.4-0.1-0.2-0.1-0.20.1
Time in novel zone, hab. session 12.62.64.0-1.1-1.5-0.0-1.81.0-1.6-1.8-2.0-1.8-2.0-1.9
Total zone transitions, hab. session 15.47.510.22.93.02.82.92.23.22.72.72.72.82.0
Total locomotion distance, hab. session 17.510.613.73.13.62.43.61.43.73.73.53.73.62.8
Locomotion velocity, hab. session 112.818.123.44.14.73.04.81.34.74.74.84.74.83.8
Time in familiar zone, hab. session 20.20.21.1-0.50.2-1.1-0.5-0.7-0.4-0.1-0.2-0.2-0.10.3
Time in novel zone, hab. session 20.20.21.1-0.1-0.31.00.11.0-0.4-0.3-0.3-0.2-0.3-0.1
Total zone transitions, hab. session 21.72.26.91.31.62.61.12.61.40.90.90.90.90.3
Total locomotion distance, hab. session 26.18.012.42.73.52.53.02.02.53.23.13.23.21.8
Locomotion velocity, hab. session 27.19.414.03.03.72.73.32.02.73.53.43.53.42.0
Novel to familiar place preference ratio0.91.03.8-1.3-1.0-1.7-0.5-1.9-0.5-0.3-0.4-0.3-0.50.5
Novelty place preference0.91.03.7-1.4-1.1-1.7-0.4-1.9-0.6-0.4-0.5-0.3-0.50.5
Time in novel zone, NPP test1.11.22.7-1.5-1.2-1.6-0.9-1.6-0.9-0.8-0.8-0.8-0.90.1
Total zone transitions, NPP test1.82.66.11.81.72.31.42.51.31.11.21.11.21.5
Total locomotion distance, NPP test7.09.612.62.93.51.93.31.33.23.53.43.53.53.2
Locomotion velocity, NPP test7.310.213.82.83.41.93.51.23.43.73.53.73.63.4
Intraocular pressure0.10.20.40.10.40.20.4-0.20.10.30.60.50.7-0.6
Delta distance traveled before/after self-admin0.30.31.40.1-0.10.90.41.20.00.0-0.1-0.1-0.40.7
Delta ambulatory time before/after self-admin0.81.02.2-0.8-1.10.8-0.51.5-0.8-1.1-1.1-1.2-1.4-0.3
Parametrial fat weight0.20.42.1-0.00.40.1-0.61.4-1.3-0.5-0.2-0.4-0.4-0.2
Pavlov. Cond. lever latency1.01.33.4-0.3-0.5-1.7-1.8-0.6-1.8-1.2-0.8-1.1-0.80.2
Pavlov. Cond. magazine entry latency0.50.62.2-0.4-0.11.4-0.31.1-0.2-0.3-0.6-0.3-0.6-1.5
Pavlov. Cond. change in total contacts0.60.64.4-0.00.21.2-0.10.70.30.1-0.30.1-0.3-2.1
Pavlov. Cond. index score0.70.93.60.30.71.91.11.10.90.80.50.80.4-0.8
Pavlov. Cond. latency score0.81.03.60.20.71.91.30.81.30.90.61.00.6-0.6
Pavlov. Cond. lever contacts1.01.23.60.30.61.41.60.61.91.20.81.20.8-0.2
Pavlov. Cond. magazine entry number0.50.62.30.1-0.1-1.50.1-1.40.30.10.40.10.51.4
Pavlov. Cond. intertrial magazine entries1.31.63.20.0-0.50.8-1.41.8-1.8-1.1-1.3-1.2-1.3-1.4
Pavlov. Cond. lever-magazine prob. diff.0.70.83.80.20.71.90.91.30.80.70.30.70.3-0.9
Pavlov. Cond. response bias0.50.72.9-0.10.21.70.71.30.70.4-0.00.4-0.0-1.2
Pavlov. Cond. lever latency0.20.31.30.2-0.5-1.10.7-0.30.40.50.40.60.40.3
Pavlov. Cond. magazine entry latency0.10.10.40.20.30.2-0.5-0.5-0.6-0.2-0.3-0.3-0.2-0.6
Pavlov. Cond. change in total contacts0.40.73.11.21.11.7-0.70.4-0.6-0.4-0.2-0.3-0.3-0.3
Pavlov. Cond. index score0.20.30.70.40.50.8-0.8-0.1-0.7-0.4-0.4-0.5-0.4-0.6
Pavlov. Cond. latency score0.10.20.70.40.70.8-0.4-0.2-0.4-0.1-0.1-0.2-0.1-0.2
Pavlov. Cond. lever contacts0.30.52.00.00.71.4-0.80.4-0.6-0.5-0.4-0.6-0.4-0.7
Pavlov. Cond. magazine entry number0.40.51.3-1.1-1.1-1.20.3-0.10.8-0.2-0.2-0.1-0.20.5
Pavlov. Cond. intertrial magazine entries0.20.31.1-0.40.2-1.00.2-0.6-0.10.50.50.50.51.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.50.50.9-0.7-0.2-0.5-0.4-0.4-0.4-0.4-0.6
Pavlov. Cond. response bias0.40.51.80.30.81.3-0.90.4-0.7-0.5-0.4-0.6-0.5-0.9
Time in closed arm before self-admin0.00.10.30.3-0.0-0.2-0.00.10.0-0.4-0.2-0.5-0.0-0.0
Time in closed arm after self-admin0.10.20.40.20.4-0.4-0.4-0.4-0.7-0.10.3-0.20.3-0.5
Time in open arm before self-admin0.60.61.10.60.70.80.80.30.21.01.11.00.61.0
Time in open arm after self-admin0.30.31.1-1.0-0.70.70.50.80.3-0.2-0.4-0.0-0.30.5
Bone: periosteal estimation0.51.13.41.20.21.3-1.01.8-1.5-0.5-0.5-0.5-0.4-1.3
Bone: periosteal perimeter0.50.93.81.70.71.3-0.21.9-0.80.20.10.20.2-0.7
Bone: post-yield work1.21.83.5-0.7-1.30.0-1.90.8-1.6-1.3-1.7-1.3-1.6-1.5
Progressive ratio test 1 active lever presses0.40.51.41.2-0.1-1.2-1.0-0.90.30.0-0.5-0.1-0.5-0.2
Progressive ratio test 1 breakpoint0.40.51.61.3-0.0-1.2-0.9-0.90.40.1-0.4-0.1-0.4-0.2
Progressive ratio test 1 inactive lever presses0.30.41.6-0.2-0.3-1.10.3-0.20.40.40.20.40.61.3
Progressive ratio test 2 active lever presses2.12.44.41.61.5-0.81.1-1.31.22.11.72.01.61.7
Progressive ratio test 2 breakpoint2.22.54.41.61.5-0.81.1-1.41.22.11.72.01.71.6
Progressive ratio test 2 inactive lever presses0.40.61.90.10.1-0.80.7-0.50.81.00.71.10.61.4
Incentive Sensitization - Responses2.73.76.01.71.8-0.41.9-0.91.62.32.52.42.42.3
Incentive Sensitization - Breakpoint2.83.65.81.51.7-0.51.9-0.91.52.32.42.42.32.3
Sum of active levers in priming session hrs 5-61.01.02.40.91.00.50.90.61.51.01.11.11.10.5
Progressive ratio0.10.20.5-0.60.1-0.00.7-0.10.20.50.30.40.30.5
Food seeking constrained by brief footshock0.30.41.20.5-0.3-1.1-0.8-1.1-0.1-0.6-0.3-0.6-0.4-0.3
Seeking ratio, punishment vs. effort0.20.20.60.6-0.1-0.4-0.8-0.4-0.5-0.5-0.4-0.4-0.4-0.4
Retroperitoneal fat weight0.93.711.83.42.70.71.4-0.21.11.72.31.82.11.1
Reaction time number correct0.20.51.90.70.40.80.71.40.50.50.30.30.4-0.8
Reaction time mean minus median0.20.51.7-1.3-0.7-0.8-0.3-0.40.0-0.6-0.4-0.6-0.61.2
Reaction time mean minus median AUC0.20.51.4-1.2-0.5-1.2-0.5-0.70.3-0.6-0.1-0.5-0.41.1
Reaction time num false alarms0.81.13.0-1.7-1.5-1.4-0.8-0.3-0.0-1.1-1.0-1.3-0.70.3
Reaction time num false alarms AUC0.50.72.5-1.6-1.2-1.2-0.4-0.20.0-0.8-0.5-0.9-0.30.7
Reaction time trials correct on left0.20.51.90.70.40.80.71.40.50.50.30.30.4-0.8
Reaction time trials on left0.20.41.90.60.30.80.71.40.50.40.20.20.3-0.8
Reaction time mean0.30.40.70.70.90.80.30.7-0.20.70.50.70.30.7
Reaction time mean AUC0.20.30.90.70.80.50.20.4-0.10.60.60.70.41.0
Median of all reaction times0.50.71.81.31.21.10.30.8-0.41.00.61.00.50.4
Reaction time omissions1.72.56.7-2.6-1.5-1.2-1.50.2-1.5-1.8-1.5-1.8-1.7-0.9
Reaction time false alarm rate0.70.92.8-1.7-1.2-1.3-0.7-0.8-0.2-0.9-0.5-0.9-0.31.0
Reaction time premature initiation rate1.82.55.11.52.31.91.60.31.21.71.81.51.70.8
Reaction time premature initiations1.52.74.91.72.21.81.90.51.51.81.91.51.80.6
Std. dev. reaction times0.20.41.6-1.1-0.5-0.5-0.30.20.0-0.4-0.2-0.4-0.51.3
Reaction time trials completed0.20.41.90.60.30.80.71.40.50.40.20.20.3-0.8
Reaction time trials AUC0.30.61.90.80.60.80.91.40.60.70.50.40.6-0.7
Run reversals in cocaine runway, females3.43.35.61.71.80.21.9-0.51.92.42.12.32.21.7
Run reversals in cocaine runway, males1.51.54.0-0.6-0.90.6-1.5-0.1-1.2-1.3-1.4-1.4-1.4-2.0
Latency to leave start box in cocaine runway0.00.10.20.30.40.1-0.10.2-0.40.20.30.10.1-0.2
Latency to leave start box in cocaine runway, F0.20.31.1-0.10.30.7-0.21.0-0.9-0.1-0.0-0.2-0.1-0.4
Latency to leave start box in cocaine runway, M0.50.51.50.60.2-0.90.4-1.21.00.60.60.50.60.6
Std. dev. time between licks in bursts0.10.21.0-0.11.00.9-0.30.4-0.3-0.10.1-0.10.10.1
Total sessions with >9 infusions0.20.30.70.70.0-0.8-0.8-0.30.10.1-0.4-0.0-0.3-0.8
Short access day 1 total inactive lever presses0.30.41.3-0.6-0.8-0.8-0.80.5-1.1-0.3-0.7-0.3-0.6-0.3
Short access day 10 total inactive lever presses0.41.16.0-2.4-1.3-0.5-0.0-0.2-0.9-0.9-0.2-0.8-0.51.2
Short access day 1 total infusions0.20.21.5-0.2-0.0-1.2-0.7-0.2-0.40.2-0.10.1-0.2-0.5
Short access day 10 total infusions2.02.66.5-0.3-1.4-1.4-2.5-0.5-1.6-1.6-1.9-1.7-2.0-1.3
Short access total infusions0.70.92.3-0.2-0.6-1.2-1.5-0.3-0.6-0.6-1.1-0.7-1.1-1.3
Short access day 1 locomotion0.91.12.1-0.8-1.2-1.1-1.3-0.7-0.5-0.9-1.3-1.0-1.5-0.9
Short access day 10 total locomotion0.61.02.7-0.7-1.20.4-0.90.9-0.9-1.0-1.4-1.0-1.6-0.2
Short access total locomotion1.11.43.0-0.6-1.6-0.8-1.3-0.2-0.2-1.4-1.6-1.4-1.7-0.7
One hour access (0.3 mA shock)1.61.97.72.81.6-0.30.7-0.71.51.71.11.50.50.7
Compulsive drug intake0.40.51.1-0.6-1.00.30.50.21.0-0.7-0.9-0.7-0.6-0.7
One hour access (shock baseline)1.11.75.52.31.6-0.80.4-1.00.71.71.11.60.51.0
Social response proportion0.91.02.61.61.20.60.71.61.10.60.90.50.70.9
Social responses4.55.88.02.62.81.82.61.22.52.62.82.72.51.9
Social time0.81.12.11.41.00.91.00.61.41.11.01.11.10.1
Soleus weight0.61.73.2-0.4-0.5-0.4-1.81.3-0.9-1.6-1.4-1.6-1.4-1.8
Bone: stiffness1.42.310.40.9-0.51.8-1.23.2-0.6-1.3-1.5-1.3-1.4-1.1
Tibialis anterior weight0.41.53.2-0.1-0.30.5-1.41.0-1.8-1.4-1.3-1.4-1.3-1.7
Time to tail flick, vehicle, before self-admin0.50.51.61.20.20.60.21.11.00.40.20.30.1-1.0
Time to tail flick, vehicle, after self-admin0.20.31.7-0.10.51.30.60.60.30.10.20.10.4-0.4
Time to tail flick, test, before self-admin0.20.21.70.5-0.20.20.21.30.3-0.2-0.0-0.3-0.00.1
Time to tail flick, test, after self-admin1.61.72.31.41.31.31.51.11.41.21.51.11.40.7
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.90.40.4-0.0-0.5-0.6-0.20.0-0.00.3-0.2
Delta time to tail flick, test, before/after SA0.60.61.20.30.80.71.1-0.71.00.70.80.70.90.6
Tibia length0.82.317.04.11.91.0-0.10.0-1.00.70.70.70.70.4
Ambulatory time before self-admin0.60.91.40.81.0-0.21.1-0.70.91.21.01.11.11.2
Ambulatory time after self-admin0.30.41.50.40.21.10.51.2-0.60.1-0.3-0.1-0.40.5
Bone: tissue strength0.90.94.40.4-0.11.6-0.22.10.8-0.5-0.6-0.6-0.6-0.7
Total heroin consumption0.70.82.70.21.11.10.91.6-0.10.80.90.70.90.5
Bone: trabecular number0.30.52.50.1-0.40.51.10.81.60.40.50.40.5-0.1
Bone: trabecular spacing0.50.74.1-0.70.2-1.3-0.4-2.0-0.80.0-0.00.1-0.00.6
Bone: trabecular thickness0.30.40.8-0.1-0.8-0.1-0.60.4-0.1-0.8-0.7-0.9-0.6-0.9
Bone: trabecular tissue density0.10.10.6-0.1-0.30.50.10.30.7-0.2-0.2-0.1-0.20.5
Water consumed over 24 hours1.31.73.00.2-1.2-1.6-1.7-0.9-1.6-1.2-1.2-1.4-1.2-1.2
Number of responses in last shaping day0.20.20.60.20.50.10.5-0.40.30.8-0.30.7-0.2-0.5