Hub : Genes

Ubd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ubd 0.21 0.11 3.9e-16 0.1 0.16 0.14 0.15 5.1e-10 1.3e-14 5.2e-13 5.5e-14
2 pVTA gene expression Ubd 0.41 0.16 0.0e+00 0.26 0.31 0.32 0.32 3.3e-21 1.4e-25 2.4e-26 3.1e-26
3 RMTg gene expression Ubd 0.22 0.12 2.2e-04 0.12 0.14 0.12 0.06 4.9e-04 1.9e-04 3.4e-04 8.9e-03
4 LHb gene expression Ubd 0.5 0.16 1.2e-09 0.35 0.34 0.34 0.35 4.4e-09 7.1e-09 9.4e-09 4.1e-09
5 Adipose gene expression Ubd 0.42 0.14 0.0e+00 0.46 0.47 0.48 0.47 2.2e-57 3.3e-58 1.3e-60 5.7e-59
6 pVTA intron excision ratio chr20_1391327_1394561 0.08 0.06 1.9e-03 0.03 0.04 0.01 0.02 3.4e-03 6.9e-04 6.5e-02 1.3e-02
7 Liver gene expression Ubd 0.66 0.16 0.0e+00 0.56 0.57 0.59 0.58 1.9e-75 2.8e-77 1.7e-80 3.0e-79
8 pVTA intron excision ratio chr20_1406684_1413368 0.39 0.13 0.0e+00 0.23 0.32 0.33 0.33 2.0e-18 6.1e-26 3.4e-27 4.3e-27

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.91.62.8-1.2-1.3-0.8-1.01.71.31.6-1.0
Area under the delay curve2.02.33.51.41.91.91.7-1.70.9-1.6-0.1
BMI with tail0.62.27.9-0.30.60.7-0.9-1.5-1.3-2.02.8
BMI without tail1.23.67.61.32.12.20.6-2.6-0.1-2.81.7
Body weight3.716.328.24.44.94.63.2-5.30.6-5.10.8
Weight adjusted by age2.64.06.52.32.22.22.6-1.81.6-1.5-1.4
Bone surface1.22.14.61.51.21.31.6-0.52.1-0.2-2.2
Bone volume0.81.44.80.90.81.11.0-0.22.20.1-1.8
Breakpoint value in progressive ratio session2.83.47.3-1.8-1.8-2.0-2.10.8-2.70.52.1
Number of licking bursts0.10.20.40.60.2-0.00.7-0.4-0.7-0.4-0.2
Context. condit. distance diff. score2.12.55.3-0.7-1.5-1.9-0.72.1-0.22.3-1.9
Locomotion velocity, session 10.10.10.30.5-0.10.00.30.20.20.2-0.6
Locomotion distance, session 10.91.21.9-1.3-1.3-1.0-1.41.2-0.21.10.5
Locomotion velocity, session 20.70.83.10.1-0.5-0.4-0.6-0.2-1.8-0.51.5
Locomotion distance, session 20.50.71.4-0.8-0.9-0.9-0.91.10.11.2-0.4
Locomotion velocity, session 30.80.93.0-0.8-0.6-0.5-1.10.1-1.4-0.21.7
Locomotion distance, session 31.31.42.0-1.3-1.4-1.4-1.21.4-0.51.3-0.0
Stereotopy head waving bouts, day 30.80.91.61.31.00.70.9-1.1-0.7-1.20.3
Stereotopy head waving duration, day 30.70.91.61.21.00.90.9-1.1-0.3-1.10.3
Locomotion velocity, session 71.82.04.1-0.6-1.5-1.0-0.62.01.12.0-1.6
Locomotion distance, session 71.92.44.7-1.4-1.7-1.3-1.12.10.92.2-1.1
Stereotopy head waving bouts, day 72.52.84.22.01.92.01.9-1.80.9-1.8-0.4
Stereotopy head waving duration, day 72.42.94.32.12.02.01.9-1.90.7-1.9-0.3
Locomotion velocity, session 81.11.33.51.91.00.51.4-0.70.1-0.4-1.6
Locomotion distance, session 81.52.25.0-0.8-1.2-1.7-0.71.90.12.2-1.9
Degree of sensitization distance0.40.51.30.70.40.40.8-0.10.90.2-1.1
Degree of sensitization stereotypy1.11.21.91.31.21.41.2-1.10.8-1.1-0.4
Conditioned locomotion1.51.83.71.21.21.10.8-1.7-1.0-1.91.3
Cocaine response after cond. corrected1.01.22.8-0.7-1.3-0.8-1.30.5-1.40.21.7
Cocaine response after cond. not corrected0.40.50.91.00.30.60.4-0.7-0.6-0.90.7
Cocaine response before conditioning7.89.314.33.63.53.43.8-2.82.3-2.4-2.0
Saline control response0.81.12.20.61.21.51.1-1.11.1-1.00.1
Bone: connectivity density1.52.34.5-1.1-1.5-1.1-0.82.11.32.1-1.7
Bone: cortical apparent density0.20.21.1-0.40.20.4-0.3-0.40.0-0.51.1
Bone: cortical area1.31.93.51.31.91.41.5-1.41.3-1.0-1.2
Bone: cortical porosity0.10.10.20.20.40.40.4-0.30.4-0.2-0.1
Bone: cortical porosity0.70.71.30.90.90.81.1-0.61.0-0.4-1.0
Bone: cortical thickness0.50.81.4-0.01.11.20.2-1.20.8-1.10.8
Bone: cortical thickness0.50.62.5-1.2-0.4-0.1-0.9-0.0-0.3-0.21.6
Bone: cortical tissue density0.20.21.1-0.40.20.3-0.3-0.4-0.1-0.51.0
Condit. Reinf. active minus inactive responses0.10.10.1-0.2-0.3-0.3-0.30.4-0.10.30.2
Condit. Reinf. active-inactive response ratio0.40.42.1-0.00.00.2-0.3-0.4-0.7-0.71.4
Condit. Reinf. active responses0.60.71.0-1.0-0.9-1.0-1.00.9-0.50.90.3
Condit. Reinf. inactive responses2.22.74.3-2.1-1.8-1.8-1.81.9-0.22.1-0.0
Incentive salience index mean0.50.61.5-0.4-0.8-1.1-0.70.7-1.20.60.3
Condit. Reinf. lever presses2.33.26.6-1.3-1.9-2.6-1.71.6-2.41.60.4
Condit. Reinf. active minus inactive responses1.21.62.41.51.41.51.6-1.11.1-0.9-0.7
Condit. Reinf. active-inactive response ratio2.02.33.92.01.71.71.7-1.70.4-1.7-0.2
Condit. Reinf. active responses0.20.20.80.20.10.10.40.30.80.5-0.9
Condit. Reinf. inactive responses0.81.02.1-1.2-1.0-1.1-0.81.30.21.4-0.6
Condit. Reinf. lever presses1.11.53.5-0.6-0.8-0.8-0.01.51.31.9-1.8
Condit. Reinf. lever reinforcers received0.20.31.00.1-0.1-0.10.30.50.70.7-1.0
Conditioned reinforcement - actives0.81.42.70.81.31.51.4-0.81.6-0.7-0.5
Conditioned reinforcement - inactives0.50.71.60.21.01.01.0-0.51.3-0.4-0.4
Conditioned locomotion0.60.81.80.71.20.91.3-0.70.9-0.5-0.7
Patch foraging indifference point 0 sec1.12.09.60.30.61.20.40.43.10.7-2.0
Patch foraging indifference point AUC1.52.23.41.41.91.71.6-1.61.3-1.2-0.8
Delay disc. indifference point, 0s delay0.70.81.51.01.00.70.4-1.2-0.7-1.20.5
Delay disc. indifference point, 16s delay0.80.81.80.31.01.30.9-0.81.2-0.90.3
Delay disc. indifference point, 2s delay1.82.03.41.61.71.51.4-1.8-0.1-1.80.1
Delay disc. indifference point, 24s delay1.41.53.11.11.31.71.2-0.91.8-0.8-0.6
Delay disc. indifference point, 4s delay3.33.55.62.02.22.02.0-2.40.2-2.20.1
Delay disc. indifference point, 8s delay1.01.22.10.71.31.11.4-0.71.4-0.5-1.1
Indifference point function ln k0.10.20.60.0-0.4-0.50.10.70.00.7-0.8
Indifference point function log k0.10.20.60.0-0.4-0.50.10.70.00.7-0.8
Patch foraging total patch changes 0 sec1.32.411.20.40.81.40.70.33.40.6-2.1
Patch foraging total patch changes 12 sec0.91.26.20.10.81.10.4-0.22.50.2-1.2
Patch foraging total patch changes 18 sec0.60.92.1-1.3-0.5-0.2-1.20.91.40.9-0.4
Patch foraging total patch changes 24 sec1.01.78.5-0.7-0.40.6-0.21.02.91.2-1.3
Patch foraging total patch changes 6 sec1.01.67.50.41.01.70.5-0.42.7-0.1-0.8
Patch foraging time to switch 0 sec1.43.06.9-1.6-1.6-1.4-2.00.6-2.3-0.02.6
Patch foraging water rate 0 sec1.94.112.71.41.61.91.9-0.43.60.2-2.8
Patch foraging water rate 12 sec0.10.20.8-0.2-0.10.20.20.20.90.3-0.4
Patch foraging water rate 18 sec0.30.40.90.50.50.60.9-0.20.90.2-0.8
Patch foraging water rate 24 sec0.30.40.70.50.80.70.7-0.80.5-0.6-0.3
Patch foraging water rate 6 sec0.10.10.3-0.6-0.2-0.10.30.30.50.4-0.3
Seeking ratio, delayed vs. immediate footshock0.40.51.20.70.50.60.2-1.1-0.4-1.00.4
Distance traveled before self-admin0.20.21.00.20.4-0.30.6-0.1-0.20.3-1.0
Distance traveled after self-admin0.30.40.70.70.60.30.6-0.8-0.6-0.70.2
Extensor digitorum longus weight1.03.910.91.91.11.42.20.13.00.5-3.3
Bone: elastic displacement0.20.20.50.30.40.60.3-0.60.2-0.70.3
Bone: elastic work0.50.71.50.60.90.80.6-1.2-0.2-1.20.6
Bone: endosteal estimation3.26.913.73.73.12.33.3-2.60.6-2.2-2.0
Bone: endosteal perimeter1.22.68.72.11.50.62.0-0.70.8-0.2-3.0
Epididymis fat weight1.03.313.3-2.7-0.60.5-2.2-0.00.7-0.53.6
Delta time in closed arm before/after self-admin0.50.41.00.70.61.00.6-0.50.8-0.5-0.1
Delta time in open arm before/after self-admin0.90.91.90.41.00.61.3-0.31.30.1-1.4
Diff in mean of infusions in LGA sessions4.04.97.0-2.4-2.6-2.6-2.22.4-1.91.91.3
Delay discount exponential model param2.12.43.7-1.5-1.9-1.9-1.81.8-0.81.70.1
Extinction: sum of active levers before priming3.23.65.2-2.1-2.0-2.2-2.21.3-2.31.01.6
Active lever presses in extinction session 63.23.28.3-1.9-1.4-1.4-1.90.6-2.40.22.9
Bone: final force1.21.93.31.01.81.70.9-1.80.6-1.70.7
Bone: final moment1.32.13.51.21.91.91.3-1.71.3-1.4-0.1
Food consumed during 24 hour testing period0.60.81.21.00.90.30.9-1.1-1.1-1.10.1
Glucose1.42.110.41.70.1-0.21.50.60.70.9-3.2
Heart weight3.35.29.42.62.43.12.0-2.12.5-2.0-1.0
Delay discount hyperbolic model param2.02.33.4-1.4-1.9-1.8-1.71.8-0.71.7-0.0
Intermittent access intake day 1-15 change0.00.00.1-0.10.1-0.1-0.1-0.2-0.3-0.10.1
Intermittent access intake escalation0.10.20.5-0.00.30.2-0.0-0.6-0.5-0.60.7
Intermittent access intake escalation 20.40.51.40.70.70.30.9-0.30.4-0.1-1.2
Intermitt. access day 1 inactive lever presses0.10.21.10.30.3-0.40.2-0.3-1.1-0.3-0.2
Intermitt. access day 15 inactive lever presses0.61.22.41.51.21.21.5-0.80.7-0.8-0.8
Intermitt. access escalation Index3.44.87.9-2.0-2.4-2.6-2.61.5-2.81.21.9
Intermittent access day 1 total infusions0.10.20.6-0.8-0.2-0.0-0.30.40.50.30.5
Intermittent access day 15 total infusions0.20.41.7-0.30.40.4-0.1-0.6-0.3-0.61.3
Intermittent access terminal intake (last 3 days)0.40.51.10.20.91.10.7-0.60.9-0.60.4
Intermittent access total infusions0.30.40.80.10.80.90.7-0.50.8-0.40.3
Intermittent access day 1 locomotion0.20.31.2-0.10.30.1-0.0-0.4-0.8-0.61.1
Intermittent access day 15 total locomotion1.32.44.61.32.01.51.2-2.2-0.6-2.10.8
Intermittent access total locomotion1.72.03.61.21.81.41.3-1.9-0.5-1.80.9
Intermittent access standard deviation1.53.15.91.22.02.02.2-1.22.4-0.8-1.5
Left kidney weight2.812.820.03.94.54.43.2-4.22.2-3.7-0.8
Right kidney weight3.717.025.84.65.15.03.9-4.82.2-4.4-0.8
Cocaine induced anxiety0.20.30.90.2-0.2-0.70.10.4-0.50.6-1.0
Post-drug Anxiety0.50.61.4-0.4-0.7-1.1-0.40.7-1.20.7-0.3
Baseline Anxiety1.51.73.0-1.7-1.5-1.2-1.61.0-0.90.81.4
Tail length4.015.725.75.14.94.24.4-4.31.6-3.6-2.2
Length with tail6.227.144.36.76.35.65.8-5.33.1-4.2-3.4
Length without tail3.912.620.64.54.24.03.7-4.21.1-3.7-0.7
Times rat made contact with spout2.22.54.3-2.1-2.0-1.6-1.81.6-0.71.31.0
Lifetime Intake0.50.61.20.41.01.10.8-0.70.9-0.60.3
Liver weight, left0.81.33.21.81.40.51.2-1.3-0.9-1.0-0.8
Liver weight, right2.95.09.43.12.61.92.4-2.7-0.5-2.5-0.6
Locomotor activity2.33.67.72.32.01.32.5-1.21.2-0.6-2.8
Locomotor testing distance1.12.07.01.51.00.71.9-0.21.40.1-2.6
Locomotor testing rearing0.51.02.21.11.30.61.1-0.80.5-0.5-1.5
Locomotion in novel chamber0.20.30.60.50.40.60.7-0.20.8-0.1-0.4
Locomotion in novel chamber post-restriction0.61.01.71.11.21.31.0-1.10.7-1.0-0.1
Fecal boli incidents, locomotor time 10.40.61.4-0.4-1.0-0.5-0.61.20.71.1-0.5
Change in fecal boli incidents, locomotor task1.21.22.40.90.70.70.5-1.2-1.3-1.61.4
Time >=10cm from walls, locomotor time 10.70.71.21.10.90.40.6-1.1-1.0-1.10.2
Bouts of movement, locomotor time 11.01.14.30.40.30.10.80.61.51.0-2.1
Total resting periods, locomotor time 10.40.51.90.50.40.20.70.20.90.5-1.4
Rest time, locomotor task time 10.50.61.10.90.80.40.5-1.0-0.9-1.00.3
Distance moved, locomotor task time 10.40.63.00.40.40.80.50.11.70.2-0.9
Vertical activity count, locomotor time 10.20.51.60.20.30.50.60.21.30.3-1.2
Time >=10cm from walls, locomotor time 20.71.11.81.41.21.11.1-0.90.8-0.8-0.9
Bouts of movement, locomotor time 20.61.01.71.21.30.71.3-1.20.1-0.8-0.8
Total resting periods, locomotor time 20.50.91.61.21.20.61.3-1.10.1-0.6-1.0
Rest time, locomotor task time 20.40.52.80.6-0.0-0.80.1-0.2-1.7-0.1-0.2
Distance moved, locomotor task time 21.01.15.10.40.91.50.5-0.42.3-0.3-0.5
Vertical activity count, locomotor time 20.20.21.3-0.20.20.4-0.10.11.10.2-0.5
Light reinforcement 10.00.10.40.0-0.00.4-0.0-0.00.7-0.1-0.0
Light reinforcement 22.33.65.72.42.12.41.9-2.01.2-1.8-0.7
Bone: marrow area3.06.612.93.63.12.23.2-2.60.5-2.2-1.9
Bone: maximum diameter1.22.36.61.81.60.81.8-0.91.0-0.3-2.6
Bone: maximum force1.22.23.81.32.01.81.3-1.80.9-1.70.1
Bone: maximum moment1.62.84.51.62.12.01.8-1.71.6-1.4-0.8
Mean time between licks in bursts0.30.82.21.30.70.21.5-0.4-0.1-0.2-1.4
Mean num. licks in bursts0.71.12.3-1.5-1.2-0.8-1.41.10.30.90.7
Cd content in liver0.30.31.9-0.0-0.00.40.20.41.40.4-0.5
Co content in liver0.20.20.7-0.00.20.80.0-0.20.8-0.30.6
Cu content in liver1.41.73.9-2.0-1.3-1.1-1.51.50.41.40.2
Fe content in liver0.70.83.6-0.1-0.00.4-0.4-0.7-0.9-1.01.9
K content in liver0.70.71.2-1.1-0.9-0.9-1.00.9-0.20.80.1
Mg content in liver0.40.40.8-0.4-0.6-0.9-0.30.7-0.40.8-0.7
Mn content in liver0.70.82.00.1-0.6-1.2-0.10.8-0.91.0-1.4
Na content in liver0.10.10.4-0.6-0.10.0-0.4-0.00.2-0.10.3
Rb content in liver0.40.50.8-0.8-0.6-0.6-0.40.80.50.9-0.6
Se content in liver0.50.61.91.40.60.31.1-0.5-0.3-0.3-1.0
Sr content in liver0.40.31.00.30.50.10.3-0.8-1.0-0.80.4
Zn content in liver0.40.41.50.1-0.0-0.00.30.51.00.7-1.2
Bone: minimum diameter0.81.53.31.81.40.51.6-1.0-0.0-0.6-1.8
Time in familiar zone, hab. session 13.43.35.9-2.4-2.2-1.9-2.31.8-0.81.41.1
Time in novel zone, hab. session 16.06.09.92.82.52.43.1-1.52.7-0.8-2.8
Total zone transitions, hab. session 10.50.71.5-0.6-0.9-0.7-0.61.20.61.2-0.9
Total locomotion distance, hab. session 10.40.61.0-0.9-0.9-0.8-0.81.00.11.0-0.3
Locomotion velocity, hab. session 10.50.71.3-1.1-0.9-0.9-1.10.8-0.50.70.4
Time in familiar zone, hab. session 21.51.62.6-1.6-1.4-1.4-1.61.0-1.00.91.0
Time in novel zone, hab. session 22.22.33.41.81.51.81.8-1.01.7-0.9-1.2
Total zone transitions, hab. session 20.10.20.4-0.5-0.4-0.4-0.60.3-0.30.20.4
Total locomotion distance, hab. session 20.81.11.6-1.2-1.3-1.1-1.21.3-0.31.10.1
Locomotion velocity, hab. session 21.11.42.0-1.4-1.4-1.4-1.41.4-0.51.30.1
Novel to familiar place preference ratio0.50.51.50.60.51.00.7-0.21.2-0.4-0.4
Novelty place preference0.80.81.71.00.81.31.0-0.61.3-0.7-0.4
Time in novel zone, NPP test1.31.32.51.31.11.61.3-0.81.5-0.8-0.6
Total zone transitions, NPP test0.71.02.5-0.4-0.7-0.4-0.21.21.31.3-1.6
Total locomotion distance, NPP test0.60.81.5-0.9-0.9-0.6-0.71.20.71.2-0.7
Locomotion velocity, NPP test1.21.73.0-1.5-1.5-1.3-1.31.70.31.7-0.5
Intraocular pressure0.40.61.3-0.4-0.5-0.4-0.20.90.81.2-1.0
Delta distance traveled before/after self-admin1.21.22.31.20.91.50.8-1.30.3-1.50.9
Delta ambulatory time before/after self-admin0.70.91.91.10.61.10.5-1.2-0.1-1.40.9
Parametrial fat weight0.51.22.01.11.31.30.9-1.40.1-1.30.6
Pavlov. Cond. lever latency0.30.41.5-1.2-0.10.1-0.70.00.4-0.10.9
Pavlov. Cond. magazine entry latency1.31.75.5-0.5-1.3-1.9-0.90.9-2.40.90.4
Pavlov. Cond. change in total contacts1.01.13.11.80.90.91.2-1.0-0.3-1.1-0.1
Pavlov. Cond. index score0.81.04.50.2-0.8-1.4-0.50.5-2.10.40.2
Pavlov. Cond. latency score0.50.73.40.4-0.5-1.1-0.20.3-1.80.3-0.0
Pavlov. Cond. lever contacts0.30.31.41.20.1-0.10.6-0.1-0.6-0.1-0.7
Pavlov. Cond. magazine entry number2.22.87.50.91.82.21.5-1.22.7-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.50.62.5-0.7-0.30.3-0.40.61.60.8-0.4
Pavlov. Cond. lever-magazine prob. diff.1.01.24.7-0.1-1.0-1.6-0.70.7-2.20.60.2
Pavlov. Cond. response bias1.01.24.70.0-1.1-1.5-0.70.7-2.20.50.4
Pavlov. Cond. lever latency0.50.71.50.60.50.30.1-1.0-1.1-1.20.9
Pavlov. Cond. magazine entry latency0.20.20.50.50.70.40.5-0.6-0.1-0.5-0.2
Pavlov. Cond. change in total contacts0.20.30.90.40.50.70.6-0.20.9-0.1-0.4
Pavlov. Cond. index score0.20.20.70.30.30.30.50.10.80.3-0.9
Pavlov. Cond. latency score0.10.10.30.10.20.20.30.00.50.2-0.5
Pavlov. Cond. lever contacts0.40.51.5-0.3-0.3-0.00.10.81.21.0-1.0
Pavlov. Cond. magazine entry number0.40.50.8-0.8-0.8-0.9-0.90.6-0.70.40.5
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.2-0.6-0.9-0.30.5-0.80.6-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.90.30.20.30.50.20.90.4-0.9
Pavlov. Cond. response bias0.30.41.40.20.10.10.50.41.00.7-1.2
Time in closed arm before self-admin0.30.40.9-0.7-0.4-0.6-0.70.1-1.0-0.10.8
Time in closed arm after self-admin0.70.72.2-0.00.50.7-0.2-0.9-0.4-1.21.5
Time in open arm before self-admin0.30.40.8-0.2-0.9-0.7-0.80.4-0.80.40.2
Time in open arm after self-admin0.40.41.3-0.1-0.4-0.7-0.10.60.11.0-1.1
Bone: periosteal estimation3.06.210.03.13.22.43.0-2.51.3-2.0-2.0
Bone: periosteal perimeter1.52.54.12.02.01.21.9-1.40.8-0.9-1.9
Bone: post-yield work1.21.77.21.30.70.31.40.11.30.7-2.7
Progressive ratio test 1 active lever presses0.40.52.7-0.6-0.00.0-0.5-0.3-0.7-0.51.6
Progressive ratio test 1 breakpoint0.40.52.5-0.50.00.1-0.4-0.3-0.6-0.51.6
Progressive ratio test 1 inactive lever presses0.20.20.8-0.9-0.20.1-0.20.30.80.40.4
Progressive ratio test 2 active lever presses0.60.72.6-1.1-0.5-0.4-0.90.4-0.60.11.6
Progressive ratio test 2 breakpoint0.70.83.2-1.1-0.5-0.4-1.00.3-0.80.11.8
Progressive ratio test 2 inactive lever presses0.10.20.40.30.70.60.5-0.40.4-0.40.1
Incentive Sensitization - Responses1.01.42.0-1.4-1.2-1.2-1.41.0-1.10.81.4
Incentive Sensitization - Breakpoint1.11.42.1-1.4-1.2-1.2-1.41.0-1.10.81.4
Sum of active levers in priming session hrs 5-60.30.30.6-0.4-0.8-0.6-0.50.7-0.60.40.4
Progressive ratio2.13.37.31.21.61.70.7-2.7-0.9-2.72.0
Food seeking constrained by brief footshock0.10.10.50.2-0.10.2-0.00.20.70.2-0.3
Seeking ratio, punishment vs. effort1.82.65.8-0.9-1.3-1.3-0.42.41.22.4-2.0
Retroperitoneal fat weight0.52.13.71.61.71.91.3-1.61.1-1.4-0.2
Reaction time number correct0.10.30.7-0.10.20.8-0.2-0.30.8-0.40.7
Reaction time mean minus median0.40.92.31.40.8-0.11.2-0.5-0.5-0.2-1.5
Reaction time mean minus median AUC0.41.03.21.30.80.11.5-0.30.1-0.1-1.8
Reaction time num false alarms0.10.10.40.60.30.30.4-0.20.0-0.4-0.4
Reaction time num false alarms AUC0.20.30.70.90.40.50.5-0.30.3-0.4-0.6
Reaction time trials correct on left0.10.30.7-0.10.20.8-0.2-0.30.8-0.40.7
Reaction time trials on left0.10.30.70.00.20.8-0.1-0.30.8-0.40.7
Reaction time mean0.71.25.11.10.6-0.41.50.2-0.00.5-2.3
Reaction time mean AUC0.81.35.31.40.7-0.11.70.00.20.4-2.3
Median of all reaction times0.60.94.10.80.4-0.41.20.30.10.6-2.0
Reaction time omissions0.30.51.81.10.2-0.30.6-0.5-1.4-0.4-0.4
Reaction time false alarm rate0.30.41.30.90.40.10.8-0.10.1-0.0-1.2
Reaction time premature initiation rate0.40.61.11.00.61.00.8-0.90.2-0.90.2
Reaction time premature initiations0.51.02.31.00.71.50.7-1.10.6-1.20.8
Std. dev. reaction times0.81.43.61.71.10.21.7-0.6-0.2-0.2-1.9
Reaction time trials completed0.10.30.70.00.20.8-0.1-0.30.8-0.40.7
Reaction time trials AUC0.10.20.6-0.00.20.8-0.2-0.30.8-0.40.7
Run reversals in cocaine runway, females0.50.52.0-0.4-0.30.00.10.81.41.0-0.8
Run reversals in cocaine runway, males2.12.14.32.11.71.21.7-1.60.2-1.3-1.2
Latency to leave start box in cocaine runway0.10.20.7-0.0-0.1-0.2-0.3-0.1-0.8-0.30.6
Latency to leave start box in cocaine runway, F0.20.30.5-0.2-0.5-0.5-0.20.60.10.7-0.7
Latency to leave start box in cocaine runway, M1.51.43.10.50.90.60.2-1.4-1.3-1.81.7
Std. dev. time between licks in bursts0.50.71.81.30.90.21.2-0.5-0.3-0.2-1.1
Total sessions with >9 infusions0.30.30.60.20.70.70.2-0.60.2-0.70.7
Short access day 1 total inactive lever presses1.11.42.61.41.61.11.4-1.40.3-1.1-0.6
Short access day 10 total inactive lever presses0.71.63.3-1.3-1.4-1.8-1.21.3-1.01.4-0.3
Short access day 1 total infusions0.20.31.40.10.30.50.40.11.20.2-0.5
Short access day 10 total infusions0.20.30.60.20.60.80.4-0.30.6-0.50.4
Short access total infusions0.50.61.40.51.01.20.7-0.61.2-0.6-0.0
Short access day 1 locomotion0.30.41.1-0.6-0.7-0.5-0.51.10.40.8-0.2
Short access day 10 total locomotion0.51.01.91.31.10.91.4-1.00.2-0.8-0.5
Short access total locomotion0.10.20.30.40.50.30.5-0.4-0.2-0.60.2
One hour access (0.3 mA shock)1.01.22.1-1.4-1.1-1.2-0.91.4-0.11.4-0.1
Compulsive drug intake4.85.89.9-2.0-2.7-3.2-2.62.2-3.11.61.1
One hour access (shock baseline)1.32.05.40.81.51.61.7-0.72.3-0.2-1.2
Social response proportion0.30.31.30.30.50.10.9-0.10.50.3-1.1
Social responses0.10.10.30.10.40.10.4-0.5-0.1-0.2-0.2
Social time0.81.16.60.0-0.2-1.3-0.0-0.1-2.6-0.10.5
Soleus weight0.92.77.32.51.20.82.2-0.60.6-0.2-2.7
Bone: stiffness0.20.31.2-0.30.10.1-0.5-0.4-0.3-0.51.1
Tibialis anterior weight0.10.31.5-0.2-0.40.5-0.10.61.20.30.1
Time to tail flick, vehicle, before self-admin2.32.46.5-1.2-1.3-1.9-1.70.8-2.50.61.3
Time to tail flick, vehicle, after self-admin0.91.22.3-0.8-1.1-1.4-1.50.7-1.50.60.9
Time to tail flick, test, before self-admin0.10.10.4-0.3-0.3-0.2-0.50.0-0.30.10.6
Time to tail flick, test, after self-admin0.40.51.4-0.5-0.6-0.9-0.60.3-1.20.20.6
Delta time to tail flick, vehicle, before/after SA0.20.21.10.2-0.00.50.10.11.10.1-0.3
Delta time to tail flick, test, before/after SA0.50.50.8-0.8-0.9-0.9-0.80.8-0.60.50.5
Tibia length1.84.98.52.92.61.92.4-2.8-0.5-2.5-0.4
Ambulatory time before self-admin0.10.10.4-0.20.2-0.40.3-0.0-0.30.3-0.6
Ambulatory time after self-admin0.30.41.10.50.40.10.3-0.8-1.0-0.70.6
Bone: tissue strength0.40.40.80.50.90.80.5-0.80.4-0.70.1
Total heroin consumption0.10.10.3-0.2-0.4-0.5-0.10.2-0.40.4-0.1
Bone: trabecular number0.71.12.0-1.1-1.2-0.6-1.01.41.01.2-0.4
Bone: trabecular spacing2.43.25.42.02.21.81.8-2.3-0.3-2.10.3
Bone: trabecular thickness1.01.32.3-1.2-1.3-1.0-1.01.50.61.5-0.6
Bone: trabecular tissue density1.11.62.61.11.61.51.4-1.31.2-1.1-0.5
Water consumed over 24 hours0.20.21.0-0.0-0.1-0.3-0.0-0.2-1.0-0.30.6
Number of responses in last shaping day2.22.45.61.71.31.81.5-0.92.4-0.6-1.5