Hub : Genes

U2surp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA intron excision ratio chr8_104940705_104946936 0.14 0.07 1.5e-07 0.13 0.15 0.16 0.16 1.6e-07 3.3e-08 9.8e-09 1.0e-08
2 NAcc intron excision ratio chr8_104940705_104946936 0.04 0.02 7.1e-05 0.03 0.03 0.04 0.04 1.6e-05 1.3e-05 1.3e-06 1.4e-06
3 Eye gene expression U2surp 0.4 0.19 2.5e-03 0.19 0.14 0.24 0.18 6.9e-04 3.2e-03 1.3e-04 8.8e-04
4 NAcc intron excision ratio chr8_104940705_104945204 0.02 0.01 6.9e-03 0.01 0.01 0.01 0.01 4.3e-03 8.9e-03 1.8e-02 1.0e-02
5 PL intron excision ratio chr8_104940705_104946936 0.03 0.02 5.1e-03 0 0.01 0.01 0.01 1.0e-01 1.8e-02 2.2e-02 1.7e-02
6 Brain intron excision ratio chr8_104940705_104946936 0.06 0.04 1.2e-03 0.05 0.04 0.04 0.04 3.5e-05 3.2e-04 7.7e-05 4.9e-05
7 pVTA intron excision ratio chr8_104940705_104946936 0.03 0.02 8.2e-03 0.01 0.01 0.01 0 2.2e-02 3.6e-02 1.0e-01 1.6e-01
8 OFC intron excision ratio chr8_104945335_104946936 0.19 0.1 4.9e-03 0.01 0.03 -0 0 1.9e-01 6.6e-02 4.1e-01 2.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.12.03.61.91.81.2-1.51.01.21.5-0.9
Area under the delay curve0.20.30.50.70.50.6-0.20.60.50.7-0.3
BMI with tail6.321.630.6-5.5-4.9-5.04.9-4.7-4.4-4.23.4
BMI without tail2.88.613.3-3.7-3.6-3.23.1-2.9-3.2-1.71.1
Body weight2.410.412.8-3.3-2.9-3.63.5-3.5-3.4-2.33.1
Weight adjusted by age0.30.40.8-0.0-0.2-0.90.4-0.9-0.90.00.7
Bone surface1.42.54.92.21.91.6-1.41.41.31.7-0.9
Bone volume1.11.93.41.91.71.4-1.31.21.21.4-0.9
Breakpoint value in progressive ratio session0.10.20.70.40.8-0.1-0.5-0.00.4-0.30.3
Number of licking bursts0.10.20.30.50.50.5-0.50.50.30.3-0.2
Context. condit. distance diff. score0.30.40.7-0.4-0.1-0.80.5-0.8-0.7-0.50.9
Locomotion velocity, session 12.32.54.5-2.1-2.0-1.61.5-1.5-1.4-1.50.6
Locomotion distance, session 15.26.69.1-3.0-2.9-2.82.5-2.6-2.7-2.21.4
Locomotion velocity, session 27.08.111.5-3.4-3.1-2.82.8-2.7-2.7-3.11.9
Locomotion distance, session 27.09.713.7-3.6-3.7-3.23.1-3.1-3.3-2.81.6
Locomotion velocity, session 31.31.52.8-1.5-1.7-1.31.1-1.3-1.2-0.90.2
Locomotion distance, session 30.10.10.3-0.0-0.0-0.30.1-0.4-0.5-0.20.3
Stereotopy head waving bouts, day 30.30.42.00.8-0.10.20.40.10.01.4-0.4
Stereotopy head waving duration, day 30.20.30.9-0.2-1.0-0.50.8-0.4-0.40.5-0.3
Locomotion velocity, session 73.43.75.6-2.2-2.4-2.21.7-2.0-2.1-1.50.7
Locomotion distance, session 70.20.30.7-0.8-0.5-0.50.2-0.4-0.6-0.50.1
Stereotopy head waving bouts, day 70.20.20.70.90.10.3-0.10.10.40.6-0.3
Stereotopy head waving duration, day 70.60.71.41.10.20.7-0.50.50.81.2-1.1
Locomotion velocity, session 84.35.28.2-2.9-2.8-2.12.2-2.1-2.1-2.51.1
Locomotion distance, session 83.04.45.4-2.3-2.1-2.22.0-2.2-2.3-2.21.4
Degree of sensitization distance0.10.10.4-0.7-0.2-0.20.1-0.0-0.0-0.2-0.1
Degree of sensitization stereotypy0.20.20.4-0.1-0.3-0.40.4-0.6-0.3-0.40.5
Conditioned locomotion0.30.40.7-0.3-0.20.7-0.50.80.7-0.3-0.8
Cocaine response after cond. corrected0.20.31.0-0.8-1.0-0.30.5-0.2-0.2-0.0-0.3
Cocaine response after cond. not corrected0.20.31.0-0.7-1.0-0.30.6-0.1-0.30.2-0.4
Cocaine response before conditioning0.00.00.20.10.0-0.1-0.00.0-0.10.3-0.4
Saline control response2.12.73.8-2.0-1.4-1.81.5-1.7-1.6-1.81.5
Bone: connectivity density1.11.72.91.71.31.3-1.41.11.21.2-1.0
Bone: cortical apparent density0.40.63.2-0.8-0.5-0.30.1-0.2-0.3-1.80.8
Bone: cortical area2.84.35.6-1.5-1.9-2.22.3-2.4-2.3-1.82.1
Bone: cortical porosity0.60.71.3-0.6-0.5-1.10.7-1.1-0.9-0.60.9
Bone: cortical porosity1.21.32.0-0.9-0.7-1.41.0-1.4-1.2-1.11.3
Bone: cortical thickness1.62.73.1-1.3-1.6-1.71.7-1.7-1.7-1.81.7
Bone: cortical thickness0.10.10.30.50.50.1-0.2-0.1-0.00.20.2
Bone: cortical tissue density0.40.63.2-0.8-0.5-0.30.1-0.1-0.3-1.80.8
Condit. Reinf. active minus inactive responses0.10.20.40.70.2-0.40.1-0.3-0.10.60.5
Condit. Reinf. active-inactive response ratio2.02.13.6-0.7-1.3-1.91.7-1.8-1.5-0.51.6
Condit. Reinf. active responses0.10.20.60.60.20.0-0.30.10.30.7-0.3
Condit. Reinf. inactive responses1.92.33.21.11.31.6-1.81.61.51.2-1.8
Incentive salience index mean0.50.61.30.1-0.5-1.00.9-1.1-0.8-0.11.1
Condit. Reinf. lever presses2.23.13.9-1.5-2.0-1.91.9-2.0-1.7-1.51.5
Condit. Reinf. active minus inactive responses0.81.13.11.21.10.5-1.10.50.61.8-0.8
Condit. Reinf. active-inactive response ratio0.20.20.90.10.1-0.2-0.4-0.0-0.11.0-0.5
Condit. Reinf. active responses1.21.63.71.61.40.9-1.30.80.81.9-1.1
Condit. Reinf. inactive responses0.70.91.51.21.00.9-0.80.60.71.2-0.9
Condit. Reinf. lever presses0.60.82.21.41.20.2-0.70.10.21.5-0.1
Condit. Reinf. lever reinforcers received1.11.53.81.61.40.7-1.20.60.71.9-0.9
Conditioned reinforcement - actives0.20.41.20.70.30.6-0.30.50.41.1-0.7
Conditioned reinforcement - inactives0.20.30.7-0.5-0.8-0.50.6-0.4-0.4-0.3-0.1
Conditioned locomotion0.10.10.30.3-0.20.20.20.20.10.5-0.2
Patch foraging indifference point 0 sec0.10.20.5-0.6-0.50.10.50.0-0.3-0.70.2
Patch foraging indifference point AUC0.20.31.6-0.6-0.30.1-0.30.10.0-1.3-0.0
Delay disc. indifference point, 0s delay1.21.31.71.31.21.1-1.11.01.11.3-0.8
Delay disc. indifference point, 16s delay0.10.10.30.1-0.1-0.40.5-0.5-0.30.20.4
Delay disc. indifference point, 2s delay0.20.20.6-0.5-0.6-0.30.8-0.2-0.60.50.1
Delay disc. indifference point, 24s delay0.10.10.30.30.50.2-0.20.20.3-0.20.1
Delay disc. indifference point, 4s delay1.01.02.30.50.31.2-0.61.31.10.9-1.5
Delay disc. indifference point, 8s delay0.30.41.00.81.00.6-0.30.50.50.50.2
Indifference point function ln k0.20.31.80.80.5-0.10.3-0.10.01.3-0.0
Indifference point function log k0.20.31.80.80.5-0.10.3-0.10.01.3-0.0
Patch foraging total patch changes 0 sec0.20.30.5-0.7-0.6-0.20.7-0.3-0.6-0.70.4
Patch foraging total patch changes 12 sec0.40.62.3-0.9-0.7-0.50.3-0.5-0.3-1.50.6
Patch foraging total patch changes 18 sec0.10.20.6-0.40.40.5-0.40.40.3-0.8-0.0
Patch foraging total patch changes 24 sec0.30.51.30.51.10.6-1.00.50.70.2-0.3
Patch foraging total patch changes 6 sec0.10.20.4-0.2-0.10.6-0.20.60.4-0.4-0.5
Patch foraging time to switch 0 sec0.61.22.40.70.71.3-1.11.31.50.5-1.0
Patch foraging water rate 0 sec0.30.61.4-0.4-0.8-0.90.9-0.9-1.20.30.3
Patch foraging water rate 12 sec0.30.61.3-0.1-0.5-0.81.1-1.0-1.10.20.6
Patch foraging water rate 18 sec2.03.05.2-1.6-1.7-1.92.2-1.8-2.3-0.61.2
Patch foraging water rate 24 sec0.10.10.30.2-0.1-0.20.5-0.4-0.50.40.2
Patch foraging water rate 6 sec0.60.91.9-0.2-0.7-1.11.2-1.1-1.40.40.6
Seeking ratio, delayed vs. immediate footshock0.10.21.0-0.20.1-0.3-0.2-0.3-0.1-1.00.2
Distance traveled before self-admin1.31.73.5-1.8-1.0-1.11.1-1.1-1.1-1.91.1
Distance traveled after self-admin0.10.20.3-0.10.60.2-0.30.20.2-0.60.5
Extensor digitorum longus weight3.011.814.2-3.8-3.6-3.63.6-3.5-3.7-3.12.6
Bone: elastic displacement1.61.92.6-1.4-0.8-1.41.3-1.4-1.3-1.61.6
Bone: elastic work0.70.91.6-0.6-0.5-1.30.9-1.2-1.0-0.51.1
Bone: endosteal estimation0.30.61.1-0.7-0.9-1.01.0-0.9-0.90.00.3
Bone: endosteal perimeter1.83.75.2-1.7-1.9-2.12.3-2.1-2.1-1.41.8
Epididymis fat weight0.41.32.2-1.5-1.4-1.20.9-1.2-1.3-0.70.2
Delta time in closed arm before/after self-admin0.30.31.0-0.3-0.3-0.40.1-0.3-0.1-1.00.8
Delta time in open arm before/after self-admin0.30.30.6-0.40.00.5-0.60.50.5-0.6-0.8
Diff in mean of infusions in LGA sessions0.20.30.90.70.8-0.1-0.2-0.20.30.9-0.2
Delay discount exponential model param0.20.20.4-0.5-0.4-0.60.1-0.6-0.5-0.60.3
Extinction: sum of active levers before priming0.40.51.1-0.50.3-0.80.1-0.7-0.3-1.01.0
Active lever presses in extinction session 60.50.52.1-0.70.2-0.5-0.0-0.4-0.2-1.50.9
Bone: final force0.10.10.40.6-0.0-0.40.2-0.5-0.20.50.1
Bone: final moment0.10.20.40.60.1-0.50.2-0.6-0.30.60.1
Food consumed during 24 hour testing period0.81.01.81.21.11.0-0.90.80.91.3-0.8
Glucose0.50.71.2-1.1-1.1-1.00.7-0.9-0.7-0.80.2
Heart weight0.71.02.0-0.5-0.4-0.91.2-1.2-1.4-0.61.4
Delay discount hyperbolic model param0.30.30.6-0.4-0.3-0.60.1-0.7-0.5-0.80.5
Intermittent access intake day 1-15 change0.00.10.20.30.40.4-0.30.20.30.1-0.1
Intermittent access intake escalation0.10.10.20.30.50.4-0.50.30.40.0-0.2
Intermittent access intake escalation 20.70.81.31.11.11.2-0.81.00.90.5-0.3
Intermitt. access day 1 inactive lever presses0.31.22.2-1.5-1.3-0.80.9-0.7-0.9-1.50.6
Intermitt. access day 15 inactive lever presses0.10.10.4-0.1-0.40.10.6-0.1-0.2-0.40.5
Intermitt. access escalation Index0.71.02.70.40.21.1-0.71.10.81.3-1.6
Intermittent access day 1 total infusions0.20.30.9-0.6-1.0-0.40.7-0.4-0.60.10.2
Intermittent access day 15 total infusions0.10.20.6-0.3-0.8-0.20.4-0.3-0.50.5-0.3
Intermittent access terminal intake (last 3 days)0.20.20.5-0.3-0.6-0.20.7-0.4-0.70.30.3
Intermittent access total infusions0.50.61.1-0.8-1.1-0.60.9-0.7-1.0-0.20.5
Intermittent access day 1 locomotion1.01.32.7-1.4-1.6-1.01.3-0.9-1.1-1.00.7
Intermittent access day 15 total locomotion0.71.32.1-1.0-1.4-1.21.4-1.2-1.2-0.70.8
Intermittent access total locomotion1.31.62.7-1.2-1.6-1.11.5-1.1-1.2-1.11.0
Intermittent access standard deviation0.40.71.3-0.1-0.9-0.71.1-0.9-1.1-0.41.1
Left kidney weight2.611.916.2-4.0-3.3-3.13.8-3.1-3.4-3.63.1
Right kidney weight3.114.018.3-4.3-3.9-3.64.2-3.4-3.6-3.63.1
Cocaine induced anxiety0.30.40.90.90.80.9-0.40.70.60.40.1
Post-drug Anxiety0.20.20.40.70.30.60.00.30.00.5-0.0
Baseline Anxiety0.50.61.3-0.8-0.9-0.90.7-0.9-1.1-0.10.2
Tail length0.31.22.51.31.11.2-1.01.10.51.6-0.7
Length with tail0.10.20.70.60.6-0.00.0-0.2-0.40.60.8
Length without tail0.31.14.1-0.1-0.1-1.01.2-1.1-0.9-0.42.0
Times rat made contact with spout1.01.12.4-0.6-0.5-1.11.1-1.2-1.0-0.91.6
Lifetime Intake0.30.40.8-0.7-0.9-0.50.7-0.6-0.8-0.10.4
Liver weight, left1.72.84.4-2.1-1.7-1.51.8-1.4-1.4-2.11.3
Liver weight, right1.62.85.0-2.2-2.2-1.41.8-1.3-1.4-1.70.9
Locomotor activity0.00.10.4-0.6-0.0-0.10.0-0.0-0.3-0.2-0.1
Locomotor testing distance0.10.10.5-0.30.30.2-0.40.1-0.00.5-0.7
Locomotor testing rearing0.40.82.1-1.5-1.0-0.90.6-0.8-1.1-0.3-0.2
Locomotion in novel chamber1.62.13.21.51.01.8-1.41.61.31.6-1.2
Locomotion in novel chamber post-restriction0.91.42.81.00.91.4-0.91.30.81.7-1.4
Fecal boli incidents, locomotor time 10.40.61.4-0.9-1.2-0.80.8-0.7-0.6-0.2-0.2
Change in fecal boli incidents, locomotor task0.10.10.2-0.5-0.3-0.10.2-0.1-0.1-0.4-0.0
Time >=10cm from walls, locomotor time 10.50.50.7-0.7-0.6-0.90.7-0.8-0.7-0.80.8
Bouts of movement, locomotor time 10.00.00.0-0.2-0.20.00.20.1-0.10.10.1
Total resting periods, locomotor time 10.10.20.3-0.5-0.5-0.30.5-0.2-0.4-0.30.3
Rest time, locomotor task time 12.73.44.7-1.6-1.4-2.01.9-2.2-1.8-1.72.0
Distance moved, locomotor task time 10.81.22.50.60.41.2-1.11.40.91.1-1.6
Vertical activity count, locomotor time 10.41.01.71.00.71.2-0.91.30.80.9-0.7
Time >=10cm from walls, locomotor time 20.10.20.6-0.00.0-0.50.2-0.6-0.6-0.20.8
Bouts of movement, locomotor time 20.50.81.2-0.7-1.0-0.91.1-0.9-0.9-0.70.9
Total resting periods, locomotor time 20.61.01.6-0.7-0.9-1.01.3-1.0-1.1-0.91.2
Rest time, locomotor task time 20.30.40.6-0.3-0.4-0.60.8-0.7-0.5-0.80.8
Distance moved, locomotor task time 20.80.92.00.80.60.8-1.10.90.61.4-1.2
Vertical activity count, locomotor time 20.50.61.30.80.90.7-0.90.60.71.2-0.4
Light reinforcement 10.00.10.40.2-0.10.00.1-0.1-0.40.6-0.3
Light reinforcement 20.10.20.40.40.1-0.50.4-0.5-0.70.50.5
Bone: marrow area0.40.81.3-0.8-1.0-1.01.2-1.0-1.0-0.10.4
Bone: maximum diameter4.68.511.1-2.8-3.2-3.03.3-3.1-3.2-2.42.3
Bone: maximum force0.20.40.8-0.1-0.4-0.70.7-0.8-0.8-0.50.9
Bone: maximum moment0.30.50.9-0.1-0.3-0.90.7-0.9-0.9-0.40.9
Mean time between licks in bursts0.20.51.9-0.2-0.2-0.60.8-0.7-0.6-0.81.4
Mean num. licks in bursts1.01.62.3-1.0-0.9-1.41.4-1.5-1.2-0.91.5
Cd content in liver0.40.51.70.61.30.5-0.90.40.60.4-0.2
Co content in liver0.30.40.9-0.3-0.2-0.90.5-0.9-0.6-0.10.7
Cu content in liver0.70.81.91.41.20.7-0.70.60.71.2-0.3
Fe content in liver0.40.51.80.80.90.2-0.50.10.11.3-0.2
K content in liver1.01.02.5-1.6-1.5-0.80.6-0.6-0.6-0.9-0.6
Mg content in liver0.20.30.8-0.9-0.7-0.40.1-0.3-0.2-0.5-0.4
Mn content in liver3.13.55.1-2.1-2.0-2.31.6-2.2-2.1-1.20.8
Na content in liver0.20.21.0-0.3-0.7-0.1-0.20.10.1-0.1-1.0
Rb content in liver0.10.10.2-0.2-0.1-0.40.1-0.4-0.20.4-0.2
Se content in liver1.72.03.11.51.41.3-1.41.31.11.8-1.5
Sr content in liver0.20.20.60.4-0.40.10.10.0-0.10.6-0.8
Zn content in liver1.11.22.50.50.81.0-1.31.21.11.0-1.6
Bone: minimum diameter0.20.30.70.40.1-0.60.5-0.9-0.70.20.8
Time in familiar zone, hab. session 16.96.78.02.62.52.8-2.62.72.82.4-2.2
Time in novel zone, hab. session 14.74.76.6-2.1-1.8-2.42.1-2.3-2.6-1.82.1
Total zone transitions, hab. session 13.95.48.6-2.8-2.9-2.52.1-2.5-2.4-2.00.9
Total locomotion distance, hab. session 12.02.85.8-2.0-2.4-1.71.6-1.5-1.4-1.50.4
Locomotion velocity, hab. session 12.73.87.8-2.4-2.8-2.01.8-1.9-1.6-1.80.4
Time in familiar zone, hab. session 21.21.22.11.41.20.9-1.00.91.11.4-0.8
Time in novel zone, hab. session 23.13.13.5-1.8-1.6-1.71.7-1.7-1.9-1.91.7
Total zone transitions, hab. session 24.05.28.3-2.5-2.9-2.52.3-2.4-2.3-1.71.0
Total locomotion distance, hab. session 21.62.14.8-1.8-2.2-1.51.5-1.3-1.2-1.00.1
Locomotion velocity, hab. session 21.72.35.4-1.9-2.3-1.51.5-1.3-1.2-1.10.1
Novel to familiar place preference ratio0.00.00.1-0.20.20.10.0-0.0-0.1-0.30.3
Novelty place preference0.10.10.3-0.30.2-0.20.2-0.2-0.3-0.40.6
Time in novel zone, NPP test0.30.30.8-0.50.1-0.50.4-0.5-0.6-0.60.9
Total zone transitions, NPP test8.512.315.6-4.0-3.9-3.73.5-3.6-3.8-3.12.2
Total locomotion distance, NPP test4.86.512.5-3.0-3.5-2.72.7-2.4-2.5-1.80.9
Locomotion velocity, NPP test3.55.010.9-2.7-3.3-2.32.3-2.0-2.1-1.70.5
Intraocular pressure0.50.71.2-1.1-0.8-0.90.5-1.0-1.0-0.80.4
Delta distance traveled before/after self-admin1.41.52.51.21.61.3-1.51.31.40.4-0.4
Delta ambulatory time before/after self-admin1.01.32.01.01.01.4-1.21.41.30.6-0.8
Parametrial fat weight0.10.20.4-0.3-0.3-0.50.1-0.4-0.40.6-0.4
Pavlov. Cond. lever latency1.11.42.00.80.91.3-1.11.41.31.1-1.4
Pavlov. Cond. magazine entry latency2.43.15.1-0.9-1.2-2.21.7-2.2-2.0-1.02.1
Pavlov. Cond. change in total contacts0.80.91.3-0.3-0.8-1.11.0-1.2-1.2-0.41.1
Pavlov. Cond. index score1.82.33.7-0.8-1.1-1.91.4-1.9-1.8-1.01.9
Pavlov. Cond. latency score1.82.33.6-0.9-1.0-1.81.4-1.9-1.7-1.11.8
Pavlov. Cond. lever contacts1.61.92.8-0.9-1.0-1.61.3-1.7-1.5-1.21.6
Pavlov. Cond. magazine entry number1.11.42.90.30.51.6-1.01.61.40.5-1.7
Pavlov. Cond. intertrial magazine entries4.14.96.52.42.52.2-2.32.12.22.3-1.7
Pavlov. Cond. lever-magazine prob. diff.1.82.23.4-0.7-1.1-1.81.5-1.8-1.7-1.01.8
Pavlov. Cond. response bias1.11.42.5-0.3-0.7-1.51.1-1.6-1.4-0.51.6
Pavlov. Cond. lever latency0.10.20.5-0.4-0.50.50.20.50.4-0.7-0.2
Pavlov. Cond. magazine entry latency1.41.73.5-0.9-0.6-1.51.2-1.5-1.4-1.11.9
Pavlov. Cond. change in total contacts0.50.91.9-0.8-0.5-1.40.7-1.3-1.2-0.20.7
Pavlov. Cond. index score0.30.41.00.00.3-0.90.3-0.8-0.70.01.0
Pavlov. Cond. latency score0.30.51.1-0.10.2-0.90.4-0.9-0.8-0.11.1
Pavlov. Cond. lever contacts0.20.30.70.20.4-0.80.2-0.8-0.70.30.8
Pavlov. Cond. magazine entry number0.70.81.70.50.31.2-0.71.11.00.7-1.3
Pavlov. Cond. intertrial magazine entries4.26.38.12.62.32.8-2.62.72.72.0-2.3
Pavlov. Cond. lever-magazine prob. diff.0.30.41.2-0.00.2-0.90.4-0.9-0.8-0.11.1
Pavlov. Cond. response bias0.40.61.2-0.00.0-1.10.4-1.1-1.00.20.9
Time in closed arm before self-admin0.10.10.6-0.4-0.30.2-0.00.30.30.2-0.8
Time in closed arm after self-admin0.40.51.2-0.8-1.1-0.50.7-0.4-0.4-0.70.4
Time in open arm before self-admin0.40.51.61.30.60.4-0.40.20.21.10.0
Time in open arm after self-admin0.91.01.31.11.01.1-1.21.11.10.5-0.8
Bone: periosteal estimation1.42.94.0-1.4-1.8-1.92.0-2.0-1.9-1.01.4
Bone: periosteal perimeter2.84.86.6-1.7-2.0-2.52.4-2.6-2.5-1.52.0
Bone: post-yield work0.10.10.40.60.50.2-0.10.0-0.1-0.00.3
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.30.10.20.1-0.1-0.20.2
Progressive ratio test 1 breakpoint0.00.10.2-0.4-0.30.00.10.1-0.1-0.30.3
Progressive ratio test 1 inactive lever presses0.20.30.70.40.30.8-0.70.80.50.2-0.6
Progressive ratio test 2 active lever presses0.30.31.00.60.2-0.5-0.1-0.6-0.51.00.1
Progressive ratio test 2 breakpoint0.20.31.10.70.4-0.3-0.3-0.5-0.41.0-0.0
Progressive ratio test 2 inactive lever presses0.00.10.10.30.30.3-0.30.10.20.3-0.0
Incentive Sensitization - Responses0.60.92.60.80.2-1.00.0-1.3-1.01.60.1
Incentive Sensitization - Breakpoint0.70.92.50.80.2-1.00.1-1.3-1.11.60.2
Sum of active levers in priming session hrs 5-60.90.81.7-0.7-0.3-1.30.6-1.3-1.0-0.41.0
Progressive ratio1.42.23.1-1.0-1.6-1.61.6-1.8-1.5-1.21.3
Food seeking constrained by brief footshock1.01.21.8-0.9-1.2-1.01.0-1.0-1.2-1.30.9
Seeking ratio, punishment vs. effort0.00.00.10.20.10.3-0.20.3-0.00.3-0.2
Retroperitoneal fat weight0.62.54.4-1.9-2.1-1.71.6-1.6-1.7-1.10.6
Reaction time number correct0.10.10.3-0.3-0.50.10.30.2-0.10.3-0.5
Reaction time mean minus median0.82.04.6-1.9-1.5-0.91.4-0.5-0.8-2.11.1
Reaction time mean minus median AUC1.02.44.5-2.1-1.9-1.21.6-0.9-1.1-2.01.0
Reaction time num false alarms1.42.02.71.41.61.6-1.41.31.41.3-1.1
Reaction time num false alarms AUC1.42.13.51.31.71.9-1.51.61.50.9-1.1
Reaction time trials correct on left0.10.10.3-0.3-0.50.10.30.2-0.10.3-0.5
Reaction time trials on left0.10.10.3-0.4-0.50.10.30.2-0.10.2-0.5
Reaction time mean0.71.14.2-1.3-0.6-0.50.8-0.4-0.2-2.01.2
Reaction time mean AUC0.30.52.4-0.9-0.3-0.00.3-0.00.2-1.60.7
Median of all reaction times0.30.42.0-0.6-0.0-0.10.2-0.20.2-1.40.8
Reaction time omissions0.10.20.5-0.20.10.4-0.40.60.7-0.2-0.6
Reaction time false alarm rate1.21.72.81.31.71.5-1.41.21.30.9-0.8
Reaction time premature initiation rate0.20.20.90.70.30.20.00.30.10.9-0.6
Reaction time premature initiations0.10.20.60.2-0.10.00.30.2-0.10.8-0.7
Std. dev. reaction times0.71.24.0-1.6-1.1-0.51.0-0.3-0.3-2.00.9
Reaction time trials completed0.10.10.3-0.4-0.50.10.30.2-0.10.2-0.5
Reaction time trials AUC0.00.10.3-0.2-0.30.20.20.30.10.3-0.6
Run reversals in cocaine runway, females0.30.30.9-0.10.30.3-0.90.40.40.2-1.0
Run reversals in cocaine runway, males1.91.93.5-0.8-0.7-1.41.5-1.6-1.7-0.91.9
Latency to leave start box in cocaine runway1.31.52.41.41.41.2-1.51.21.30.5-0.6
Latency to leave start box in cocaine runway, F1.61.82.81.11.41.5-1.71.51.60.4-1.0
Latency to leave start box in cocaine runway, M0.20.21.01.00.40.3-0.40.30.30.4-0.0
Std. dev. time between licks in bursts0.00.00.1-0.00.00.0-0.10.10.20.2-0.3
Total sessions with >9 infusions0.10.10.3-0.3-0.10.3-0.30.40.2-0.2-0.6
Short access day 1 total inactive lever presses0.70.92.6-1.6-1.3-0.00.30.10.0-1.6-0.2
Short access day 10 total inactive lever presses0.41.01.6-1.0-1.1-1.00.9-1.0-0.9-1.20.9
Short access day 1 total infusions0.30.40.8-0.1-0.10.9-0.40.90.70.1-0.9
Short access day 10 total infusions0.50.61.1-1.0-1.0-0.50.8-0.6-0.9-0.70.6
Short access total infusions0.10.10.2-0.4-0.40.2-0.10.20.1-0.1-0.4
Short access day 1 locomotion0.30.41.3-0.6-0.60.5-0.30.70.5-0.3-1.1
Short access day 10 total locomotion1.63.06.7-2.0-1.8-1.41.5-1.3-1.2-2.61.7
Short access total locomotion1.21.43.3-1.8-1.4-0.90.9-0.7-0.8-1.80.5
One hour access (0.3 mA shock)0.40.51.30.80.60.6-0.60.60.41.1-0.6
Compulsive drug intake5.36.39.62.22.52.6-3.12.72.52.0-2.5
One hour access (shock baseline)0.20.40.60.3-0.3-0.60.8-0.8-0.70.50.8
Social response proportion0.20.30.70.20.70.5-0.30.40.4-0.80.6
Social responses0.10.10.2-0.1-0.0-0.20.3-0.3-0.4-0.50.5
Social time0.10.20.7-0.20.40.2-0.1-0.0-0.1-0.70.8
Soleus weight0.82.33.6-1.9-1.7-1.61.6-1.5-1.6-1.10.8
Bone: stiffness0.10.20.50.4-0.3-0.30.5-0.5-0.6-0.10.7
Tibialis anterior weight0.72.43.8-1.9-1.5-1.61.6-1.5-1.8-1.21.2
Time to tail flick, vehicle, before self-admin0.00.00.1-0.0-0.2-0.2-0.1-0.1-0.10.2-0.4
Time to tail flick, vehicle, after self-admin0.81.01.6-1.2-1.3-1.20.8-1.0-0.9-1.00.6
Time to tail flick, test, before self-admin0.10.20.60.3-0.7-0.00.5-0.0-0.10.5-0.2
Time to tail flick, test, after self-admin0.30.30.90.5-0.2-0.60.3-0.6-0.61.00.1
Delta time to tail flick, vehicle, before/after SA0.60.61.7-1.1-0.6-0.60.5-0.4-0.4-1.30.7
Delta time to tail flick, test, before/after SA0.10.10.30.20.2-0.2-0.3-0.2-0.00.5-0.3
Tibia length0.10.20.4-0.5-0.6-0.40.7-0.4-0.4-0.10.3
Ambulatory time before self-admin1.31.92.9-1.7-1.2-1.21.2-1.2-1.3-1.71.1
Ambulatory time after self-admin0.20.20.8-0.30.20.3-0.10.30.1-0.90.5
Bone: tissue strength0.10.10.2-0.1-0.3-0.30.4-0.2-0.40.00.1
Total heroin consumption0.60.61.50.60.6-1.10.4-1.2-0.60.61.0
Bone: trabecular number1.52.65.22.32.01.5-1.71.11.41.5-0.9
Bone: trabecular spacing0.30.41.3-1.2-0.8-0.20.40.0-0.1-1.1-0.0
Bone: trabecular thickness0.40.51.20.40.40.4-0.80.40.51.0-1.1
Bone: trabecular tissue density1.52.23.0-1.7-1.5-1.61.2-1.4-1.4-1.71.2
Water consumed over 24 hours0.20.31.10.90.30.00.2-0.2-0.01.10.1
Number of responses in last shaping day0.90.92.2-1.5-1.3-0.30.9-0.3-0.6-1.50.3