Hub : Genes

Tyrobp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg isoform ratio NM_212525.1 0.16 0.1 1.3e-03 0.05 0.06 0.03 0.06 2.3e-02 9.1e-03 5.5e-02 1.4e-02
2 Liver isoform ratio XM_008759166.4 0.34 0.12 0.0e+00 0.36 0.37 0.37 0.36 1.1e-41 1.3e-43 1.5e-43 3.0e-42
3 Liver isoform ratio NM_212525.1 0.35 0.12 0.0e+00 0.36 0.38 0.38 0.37 2.4e-42 2.9e-44 3.8e-44 6.7e-43
4 pVTA isoform ratio XM_008759166.4 0.07 0.06 9.7e-05 0.06 0.05 0.05 0.06 1.4e-05 3.9e-05 3.3e-05 3.3e-05
5 pVTA isoform ratio NM_212525.1 0.07 0.05 8.3e-05 0.06 0.06 0.06 0.06 9.9e-06 2.8e-05 1.7e-05 2.4e-05
6 Adipose gene expression Tyrobp 0.07 0.05 2.3e-06 0.02 0.04 0.04 0.04 8.7e-04 3.5e-05 3.1e-05 5.9e-05
7 Brain gene expression Tyrobp 0.03 0.02 3.9e-03 0.01 0.02 0.01 0.01 3.4e-02 4.7e-03 4.6e-02 1.2e-02
8 RMTg isoform ratio XM_008759166.4 0.15 0.1 3.0e-03 0.04 0.04 -0 0.03 2.8e-02 3.2e-02 3.5e-01 4.7e-02
9 Liver gene expression Tyrobp 0.05 0.04 3.3e-04 0.02 0.02 0.01 0.02 2.1e-03 2.2e-03 2.9e-02 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.71.22.2-0.81.0-1.01.3-1.3-1.0-1.3-0.2-1.5
Area under the delay curve0.40.51.3-0.90.6-0.60.6-0.6-0.6-0.21.10.7
BMI with tail0.10.31.00.2-0.60.6-0.20.20.30.70.51.0
BMI without tail0.20.61.3-1.00.8-0.70.8-0.8-0.8-0.61.10.2
Body weight2.812.216.2-3.63.6-3.64.0-4.0-3.5-3.82.1-2.7
Weight adjusted by age0.10.10.4-0.20.2-0.20.5-0.5-0.6-0.30.2-0.3
Bone surface1.42.63.2-1.81.7-1.71.8-1.8-1.8-1.61.3-0.9
Bone volume1.62.83.6-1.71.7-1.71.9-1.9-1.9-1.81.0-1.2
Breakpoint value in progressive ratio session0.81.01.8-1.41.1-1.11.0-1.0-1.1-0.80.90.5
Number of licking bursts1.93.15.11.7-1.81.8-1.81.81.42.30.22.2
Context. condit. distance diff. score0.20.31.3-0.30.0-0.0-0.10.1-0.50.21.11.0
Locomotion velocity, session 10.50.50.90.9-0.80.8-0.60.60.70.3-1.0-0.5
Locomotion distance, session 10.70.92.2-1.00.9-0.90.8-0.8-1.5-0.71.20.0
Locomotion velocity, session 20.70.81.50.9-0.80.8-1.21.20.90.9-0.90.4
Locomotion distance, session 21.11.52.90.9-1.21.2-1.41.40.71.50.31.7
Locomotion velocity, session 30.20.20.50.4-0.40.3-0.70.70.10.5-0.20.3
Locomotion distance, session 33.23.56.6-2.42.1-2.01.4-1.4-2.3-1.22.60.6
Stereotopy head waving bouts, day 31.31.54.91.4-1.11.1-0.70.71.50.4-2.2-0.9
Stereotopy head waving duration, day 32.12.56.51.9-1.61.6-1.11.12.00.9-2.5-0.6
Locomotion velocity, session 70.50.61.7-0.90.7-0.70.5-0.5-1.0-0.41.30.4
Locomotion distance, session 70.30.30.8-0.60.7-0.70.3-0.3-0.9-0.60.6-0.4
Stereotopy head waving bouts, day 71.41.62.61.1-1.31.3-1.31.30.91.6-0.01.6
Stereotopy head waving duration, day 72.02.43.11.6-1.81.8-1.61.61.51.8-0.81.3
Locomotion velocity, session 83.23.95.41.7-2.02.0-2.32.31.62.3-0.12.2
Locomotion distance, session 80.91.24.30.3-0.60.6-1.11.1-0.01.31.42.1
Degree of sensitization distance0.60.61.51.0-0.70.7-0.50.50.80.2-1.2-0.8
Degree of sensitization stereotypy1.21.33.60.7-1.01.0-1.11.10.51.50.71.9
Conditioned locomotion0.60.71.20.7-0.90.9-0.80.81.01.0-0.11.1
Cocaine response after cond. corrected0.40.51.90.7-0.40.4-0.20.20.7-0.1-1.4-1.0
Cocaine response after cond. not corrected0.60.72.50.7-0.20.2-0.20.20.6-0.4-1.6-1.5
Cocaine response before conditioning1.41.62.2-1.21.5-1.51.2-1.2-1.5-1.40.6-1.0
Saline control response0.10.20.50.5-0.40.4-0.40.40.40.1-0.7-0.3
Bone: connectivity density0.20.40.5-0.60.7-0.70.7-0.7-0.7-0.60.0-0.4
Bone: cortical apparent density1.11.52.11.3-1.41.4-1.41.41.01.3-0.50.9
Bone: cortical area1.32.03.1-1.41.6-1.61.3-1.3-1.3-1.80.7-1.6
Bone: cortical porosity1.01.03.80.5-0.70.7-0.90.90.41.50.62.0
Bone: cortical porosity1.51.65.20.7-0.90.9-1.21.20.61.80.72.3
Bone: cortical thickness0.50.82.0-0.70.9-0.90.8-0.8-0.7-1.2-0.0-1.4
Bone: cortical thickness0.60.71.01.0-0.90.9-0.80.81.00.6-0.8-0.2
Bone: cortical tissue density1.31.82.31.4-1.51.5-1.51.51.11.5-0.41.1
Condit. Reinf. active minus inactive responses0.20.20.40.5-0.60.6-0.30.30.70.5-0.20.4
Condit. Reinf. active-inactive response ratio0.60.61.90.9-0.70.7-0.20.21.30.3-1.4-0.5
Condit. Reinf. active responses1.92.33.31.5-1.71.7-1.51.51.51.8-0.31.6
Condit. Reinf. inactive responses2.12.55.41.1-1.51.5-1.81.80.92.00.72.3
Incentive salience index mean0.20.20.50.4-0.50.5-0.40.40.60.60.00.7
Condit. Reinf. lever presses0.10.10.8-0.1-0.00.1-0.20.20.00.40.50.9
Condit. Reinf. active minus inactive responses0.71.01.6-1.21.3-1.30.9-0.9-0.9-1.10.2-0.7
Condit. Reinf. active-inactive response ratio0.10.10.20.3-0.30.3-0.50.50.30.2-0.4-0.1
Condit. Reinf. active responses2.53.55.3-2.22.3-2.31.8-1.8-1.9-1.91.1-0.9
Condit. Reinf. inactive responses3.64.77.3-2.72.6-2.62.1-2.1-2.3-1.82.0-0.2
Condit. Reinf. lever presses6.08.310.7-3.13.3-3.33.1-3.1-2.8-3.11.5-2.0
Condit. Reinf. lever reinforcers received3.04.26.1-2.52.5-2.41.9-1.9-2.2-2.01.5-0.8
Conditioned reinforcement - actives0.40.71.21.1-0.80.8-0.90.90.60.8-0.90.1
Conditioned reinforcement - inactives0.60.83.7-0.90.4-0.4-0.00.0-0.60.51.51.9
Conditioned locomotion2.02.63.31.7-1.71.7-1.81.81.51.8-0.91.3
Patch foraging indifference point 0 sec0.00.10.2-0.40.4-0.40.2-0.2-0.1-0.10.20.1
Patch foraging indifference point AUC0.60.91.21.0-1.01.0-1.11.11.01.0-0.80.5
Delay disc. indifference point, 0s delay1.01.14.6-0.80.3-0.30.7-0.7-1.00.12.21.4
Delay disc. indifference point, 16s delay0.60.71.7-1.10.8-0.80.6-0.6-0.6-0.31.30.9
Delay disc. indifference point, 2s delay1.11.22.6-1.31.0-1.01.0-1.0-1.3-0.71.60.3
Delay disc. indifference point, 24s delay1.51.73.0-1.71.5-1.51.1-1.1-1.3-1.11.50.0
Delay disc. indifference point, 4s delay0.20.21.1-0.20.0-0.0-0.10.1-0.20.40.61.0
Delay disc. indifference point, 8s delay0.10.10.2-0.50.4-0.40.3-0.3-0.4-0.20.50.1
Indifference point function ln k0.20.30.5-0.60.6-0.60.6-0.6-0.4-0.70.3-0.5
Indifference point function log k0.20.30.5-0.60.6-0.60.6-0.6-0.4-0.70.3-0.5
Patch foraging total patch changes 0 sec0.10.10.3-0.50.6-0.60.3-0.3-0.3-0.20.30.1
Patch foraging total patch changes 12 sec0.10.10.50.3-0.10.1-0.20.20.40.1-0.7-0.2
Patch foraging total patch changes 18 sec0.10.10.40.1-0.10.1-0.30.3-0.10.40.20.6
Patch foraging total patch changes 24 sec0.71.22.9-1.11.0-1.00.9-0.9-1.4-0.71.70.2
Patch foraging total patch changes 6 sec0.00.10.30.00.1-0.1-0.30.30.30.0-0.5-0.1
Patch foraging time to switch 0 sec0.51.01.71.2-1.01.0-0.90.91.30.8-1.20.1
Patch foraging water rate 0 sec0.40.71.20.7-0.80.8-1.11.10.81.0-0.10.9
Patch foraging water rate 12 sec0.71.42.7-1.31.3-1.31.2-1.2-1.7-0.81.4-0.1
Patch foraging water rate 18 sec0.00.10.20.3-0.20.2-0.30.30.50.3-0.10.1
Patch foraging water rate 24 sec0.60.93.4-0.70.3-0.30.1-0.1-0.70.51.81.8
Patch foraging water rate 6 sec1.42.03.6-1.71.5-1.51.3-1.3-1.7-0.81.90.5
Seeking ratio, delayed vs. immediate footshock1.92.36.3-1.61.4-1.41.4-1.4-1.8-0.82.50.6
Distance traveled before self-admin0.10.10.2-0.30.3-0.30.1-0.1-0.3-0.20.40.2
Distance traveled after self-admin1.92.33.3-1.71.8-1.81.4-1.4-1.7-1.70.8-0.9
Extensor digitorum longus weight0.31.12.01.3-1.21.2-0.50.51.40.2-1.3-1.1
Bone: elastic displacement0.10.10.50.20.1-0.10.1-0.10.1-0.2-0.6-0.7
Bone: elastic work1.62.12.9-1.41.5-1.51.7-1.7-1.5-1.60.6-1.3
Bone: endosteal estimation1.32.93.6-1.81.9-1.91.7-1.7-1.6-1.91.2-1.2
Bone: endosteal perimeter1.02.23.2-1.81.7-1.71.3-1.3-1.4-1.51.6-0.7
Epididymis fat weight0.00.10.2-0.10.0-0.00.4-0.4-0.2-0.2-0.1-0.4
Delta time in closed arm before/after self-admin1.11.01.4-1.11.0-1.01.2-1.2-0.7-1.01.0-0.6
Delta time in open arm before/after self-admin0.40.41.60.7-0.50.5-0.60.60.50.6-1.3-0.1
Diff in mean of infusions in LGA sessions0.80.92.00.6-0.90.9-1.11.11.11.1-0.01.4
Delay discount exponential model param0.40.51.10.9-0.70.7-0.60.60.60.3-1.0-0.5
Extinction: sum of active levers before priming3.23.55.7-1.61.8-1.82.2-2.2-1.6-2.4-0.2-2.1
Active lever presses in extinction session 61.81.86.5-0.51.0-1.01.0-1.0-0.5-1.8-1.4-2.5
Bone: final force1.52.43.0-1.61.6-1.61.7-1.7-1.7-1.70.9-1.1
Bone: final moment2.03.34.2-1.91.9-1.91.9-1.9-1.9-2.01.0-1.5
Food consumed during 24 hour testing period0.81.12.8-1.31.1-1.10.8-0.8-1.1-0.51.70.6
Glucose0.30.52.00.9-0.60.5-0.40.40.50.1-1.4-0.9
Heart weight0.10.20.4-0.50.3-0.30.3-0.3-0.30.10.60.6
Delay discount hyperbolic model param0.30.40.90.8-0.60.6-0.50.50.50.2-1.0-0.6
Intermittent access intake day 1-15 change1.42.84.1-1.71.6-1.62.0-2.0-1.7-1.71.6-1.2
Intermittent access intake escalation1.12.33.4-1.31.3-1.41.9-1.9-1.5-1.61.2-1.4
Intermittent access intake escalation 21.11.31.9-1.01.2-1.21.2-1.2-0.9-1.40.5-1.3
Intermitt. access day 1 inactive lever presses1.03.97.2-2.72.4-2.41.7-1.7-2.0-1.71.90.2
Intermitt. access day 15 inactive lever presses0.71.44.0-1.61.2-1.10.7-0.7-1.0-0.32.01.3
Intermitt. access escalation Index0.20.31.20.0-0.20.2-0.40.4-0.10.51.11.1
Intermittent access day 1 total infusions1.32.05.91.0-1.31.2-1.41.40.41.90.72.4
Intermittent access day 15 total infusions0.30.42.0-0.30.1-0.10.3-0.3-0.80.31.41.0
Intermittent access terminal intake (last 3 days)0.50.62.80.0-0.20.2-0.30.3-0.30.81.41.7
Intermittent access total infusions0.60.72.90.3-0.50.5-0.50.5-0.21.01.11.7
Intermittent access day 1 locomotion1.31.77.80.3-0.70.7-1.11.10.11.61.22.8
Intermittent access day 15 total locomotion0.30.62.1-0.50.2-0.20.1-0.1-0.70.41.51.3
Intermittent access total locomotion1.01.23.90.7-0.90.9-1.01.00.41.50.62.0
Intermittent access standard deviation2.24.56.0-2.42.3-2.32.2-2.2-2.5-1.92.2-0.4
Left kidney weight2.110.013.7-2.93.2-3.23.7-3.7-3.3-3.51.4-3.1
Right kidney weight2.611.716.2-3.03.4-3.44.0-4.0-3.3-3.91.0-3.7
Cocaine induced anxiety0.00.00.10.1-0.20.20.0-0.00.2-0.1-0.3-0.2
Post-drug Anxiety0.20.20.50.2-0.40.5-0.40.40.70.4-0.10.7
Baseline Anxiety0.30.31.6-0.40.2-0.2-0.20.2-0.10.40.81.3
Tail length4.417.120.6-4.34.5-4.54.4-4.4-4.3-4.52.3-3.3
Length with tail6.226.832.7-5.45.6-5.65.7-5.7-5.2-5.62.8-4.0
Length without tail2.99.512.1-3.13.3-3.33.5-3.5-3.1-3.41.6-2.6
Times rat made contact with spout0.50.51.21.1-0.80.8-0.20.20.70.2-1.0-0.9
Lifetime Intake0.50.61.70.6-0.60.6-0.60.6-0.01.00.61.3
Liver weight, left0.40.71.01.0-0.90.9-0.80.80.90.8-0.80.3
Liver weight, right0.50.92.21.0-0.80.8-1.01.01.10.6-1.5-0.3
Locomotor activity0.91.45.41.3-0.90.9-0.60.61.20.3-2.3-1.1
Locomotor testing distance0.61.03.01.4-1.01.0-0.70.70.90.6-1.7-0.6
Locomotor testing rearing1.01.93.31.8-1.61.6-1.51.51.01.4-1.00.4
Locomotion in novel chamber0.50.71.70.7-0.70.7-0.90.91.30.4-1.2-0.1
Locomotion in novel chamber post-restriction0.10.20.40.2-0.20.3-0.60.60.60.2-0.20.3
Fecal boli incidents, locomotor time 12.73.94.92.0-2.12.1-2.22.22.21.8-1.91.0
Change in fecal boli incidents, locomotor task0.50.51.70.4-0.10.1-0.10.10.8-0.4-1.3-1.3
Time >=10cm from walls, locomotor time 10.00.00.10.2-0.20.2-0.20.20.30.2-0.30.0
Bouts of movement, locomotor time 11.11.23.5-1.30.9-0.90.7-0.7-1.3-0.41.91.0
Total resting periods, locomotor time 10.70.82.5-1.10.8-0.80.6-0.6-1.0-0.31.60.9
Rest time, locomotor task time 12.02.43.51.5-1.71.7-1.71.71.91.5-1.11.1
Distance moved, locomotor task time 10.10.10.4-0.30.4-0.40.3-0.3-0.5-0.30.6-0.1
Vertical activity count, locomotor time 11.02.43.3-1.81.8-1.81.5-1.5-1.7-1.41.4-0.5
Time >=10cm from walls, locomotor time 21.31.92.71.3-1.31.3-1.61.61.41.4-0.71.2
Bouts of movement, locomotor time 20.00.00.1-0.10.2-0.20.1-0.1-0.3-0.00.10.0
Total resting periods, locomotor time 20.00.00.10.1-0.00.0-0.20.2-0.00.2-0.20.1
Rest time, locomotor task time 20.50.60.90.8-0.80.8-0.90.90.90.8-0.80.5
Distance moved, locomotor task time 20.10.10.5-0.0-0.00.00.1-0.1-0.20.20.70.4
Vertical activity count, locomotor time 20.81.01.8-1.21.1-1.11.0-1.0-1.1-0.81.3-0.1
Light reinforcement 10.00.10.50.1-0.10.1-0.30.30.10.50.10.7
Light reinforcement 22.13.34.91.8-2.02.0-1.91.92.21.9-1.31.2
Bone: marrow area1.32.93.7-1.81.9-1.91.8-1.8-1.6-1.91.2-1.3
Bone: maximum diameter1.12.12.7-1.61.6-1.61.4-1.4-1.3-1.61.1-1.2
Bone: maximum force2.54.55.5-2.32.2-2.22.4-2.4-2.3-2.31.4-1.4
Bone: maximum moment3.05.36.4-2.42.5-2.52.5-2.5-2.4-2.51.5-1.7
Mean time between licks in bursts0.10.20.8-0.40.2-0.2-0.10.1-0.20.20.90.8
Mean num. licks in bursts1.21.95.6-0.81.1-1.11.4-1.4-0.8-1.8-0.7-2.4
Cd content in liver0.10.10.20.4-0.40.4-0.10.10.30.3-0.0-0.0
Co content in liver0.60.71.20.9-0.80.9-0.80.81.10.6-1.1-0.0
Cu content in liver1.01.21.6-1.21.1-1.11.3-1.3-1.2-1.10.8-0.7
Fe content in liver0.40.50.80.8-0.70.7-0.60.60.90.7-0.80.3
K content in liver0.00.00.0-0.20.2-0.2-0.00.00.2-0.1-0.2-0.0
Mg content in liver0.91.02.61.0-0.80.8-0.90.91.40.5-1.6-0.3
Mn content in liver1.21.33.81.2-0.90.9-1.01.01.40.5-1.9-0.6
Na content in liver0.80.81.3-1.01.1-1.10.8-0.8-1.0-0.90.7-0.4
Rb content in liver0.20.20.90.2-0.50.5-0.30.30.40.60.31.0
Se content in liver6.07.110.43.0-2.82.8-2.82.83.22.3-2.90.5
Sr content in liver0.40.30.80.6-0.40.4-0.50.50.70.3-0.9-0.3
Zn content in liver2.52.74.61.9-1.81.8-1.51.52.21.5-1.80.4
Bone: minimum diameter2.95.37.7-2.82.6-2.62.1-2.1-2.6-2.12.5-0.5
Time in familiar zone, hab. session 10.60.63.1-0.20.4-0.40.5-0.5-0.2-1.1-0.7-1.8
Time in novel zone, hab. session 11.41.44.50.7-0.91.0-1.01.01.01.70.42.1
Total zone transitions, hab. session 10.10.21.0-0.2-0.00.0-0.10.1-0.40.21.00.7
Total locomotion distance, hab. session 10.91.32.0-1.31.3-1.31.1-1.1-1.4-0.90.9-0.2
Locomotion velocity, hab. session 10.50.81.3-0.91.0-1.00.9-0.9-1.1-0.80.3-0.4
Time in familiar zone, hab. session 21.11.22.1-1.01.2-1.11.0-1.0-0.3-1.4-0.6-1.5
Time in novel zone, hab. session 20.60.71.10.9-1.01.0-0.80.80.51.10.10.8
Total zone transitions, hab. session 22.53.24.71.8-1.91.9-2.02.01.62.2-0.31.8
Total locomotion distance, hab. session 20.20.31.60.1-0.20.2-0.20.20.10.80.61.3
Locomotion velocity, hab. session 20.20.31.20.3-0.40.4-0.40.40.20.80.31.1
Novel to familiar place preference ratio0.20.20.4-0.50.4-0.40.4-0.4-0.2-0.20.60.3
Novelty place preference0.10.10.5-0.50.4-0.40.3-0.3-0.2-0.10.70.4
Time in novel zone, NPP test0.10.10.5-0.30.2-0.20.1-0.1-0.00.10.70.5
Total zone transitions, NPP test0.00.00.10.2-0.20.2-0.30.3-0.20.10.00.0
Total locomotion distance, NPP test2.23.03.8-1.71.9-1.91.9-1.9-1.9-1.90.7-1.4
Locomotion velocity, NPP test2.23.24.0-1.82.0-2.02.0-2.0-1.8-1.90.4-1.5
Intraocular pressure0.10.20.8-0.0-0.20.2-0.50.50.00.30.50.9
Delta distance traveled before/after self-admin2.12.22.8-1.61.7-1.71.5-1.5-1.6-1.60.6-1.1
Delta ambulatory time before/after self-admin2.02.53.2-1.71.7-1.71.7-1.7-1.8-1.60.9-0.9
Parametrial fat weight0.81.85.71.2-0.80.8-0.60.61.6-0.2-2.4-2.1
Pavlov. Cond. lever latency0.10.20.5-0.10.1-0.10.5-0.5-0.1-0.50.1-0.7
Pavlov. Cond. magazine entry latency0.50.61.01.0-0.70.7-0.80.80.60.9-1.00.3
Pavlov. Cond. change in total contacts0.50.52.10.2-0.30.3-0.80.80.21.00.51.5
Pavlov. Cond. index score0.40.50.80.8-0.50.5-0.80.80.60.9-0.70.6
Pavlov. Cond. latency score0.20.30.50.4-0.30.3-0.70.70.30.7-0.30.7
Pavlov. Cond. lever contacts0.10.10.2-0.20.3-0.3-0.30.3-0.10.20.10.4
Pavlov. Cond. magazine entry number0.30.40.8-0.80.5-0.50.6-0.6-0.5-0.90.5-0.6
Pavlov. Cond. intertrial magazine entries0.91.01.71.0-1.11.1-1.31.31.20.9-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.60.71.20.9-0.70.7-1.01.00.81.1-0.70.7
Pavlov. Cond. response bias0.30.41.10.8-0.40.4-0.60.60.70.5-1.0-0.1
Pavlov. Cond. lever latency4.66.27.92.8-2.82.8-2.82.82.52.4-1.91.1
Pavlov. Cond. magazine entry latency2.93.54.7-2.12.2-2.22.1-2.1-1.7-1.81.2-0.9
Pavlov. Cond. change in total contacts6.810.913.7-3.73.6-3.63.6-3.6-3.5-3.12.9-1.3
Pavlov. Cond. index score5.37.19.0-2.93.0-3.03.0-3.0-2.7-2.61.9-1.3
Pavlov. Cond. latency score4.66.17.8-2.82.8-2.82.8-2.8-2.4-2.41.8-1.1
Pavlov. Cond. lever contacts4.96.88.6-2.92.9-2.92.9-2.9-2.7-2.52.1-1.1
Pavlov. Cond. magazine entry number4.25.17.12.3-2.42.4-2.72.72.32.3-1.51.4
Pavlov. Cond. intertrial magazine entries0.91.32.11.2-1.31.3-1.51.51.11.1-0.40.8
Pavlov. Cond. lever-magazine prob. diff.5.06.78.8-2.82.9-2.93.0-3.0-2.6-2.61.7-1.4
Pavlov. Cond. response bias6.18.310.4-3.23.2-3.13.2-3.2-3.1-2.72.4-1.2
Time in closed arm before self-admin1.11.42.61.1-1.31.3-1.21.20.71.60.11.6
Time in closed arm after self-admin0.30.31.5-0.40.0-0.0-0.00.0-0.00.21.21.2
Time in open arm before self-admin3.43.76.0-1.92.2-2.21.9-1.9-1.5-2.40.5-2.2
Time in open arm after self-admin1.11.22.7-0.81.1-1.21.0-1.0-0.9-1.2-0.6-1.6
Bone: periosteal estimation1.94.05.5-2.12.2-2.22.0-2.0-1.9-2.31.2-1.8
Bone: periosteal perimeter1.01.72.6-1.41.5-1.51.1-1.1-1.0-1.60.7-1.3
Bone: post-yield work2.23.24.6-2.21.9-1.91.7-1.7-2.0-1.42.10.0
Progressive ratio test 1 active lever presses0.30.41.5-0.40.3-0.30.2-0.2-0.80.21.21.0
Progressive ratio test 1 breakpoint0.40.51.7-0.50.4-0.40.2-0.2-0.90.21.31.0
Progressive ratio test 1 inactive lever presses1.11.55.6-1.10.6-0.60.1-0.1-1.20.52.12.4
Progressive ratio test 2 active lever presses0.10.10.30.4-0.40.4-0.10.1-0.20.40.50.4
Progressive ratio test 2 breakpoint0.10.20.30.5-0.50.5-0.20.2-0.10.50.50.4
Progressive ratio test 2 inactive lever presses0.71.24.3-1.10.5-0.50.3-0.3-0.90.22.11.9
Incentive Sensitization - Responses0.20.30.70.8-0.80.8-0.40.40.30.70.20.4
Incentive Sensitization - Breakpoint0.20.30.60.7-0.80.8-0.40.40.30.70.30.5
Sum of active levers in priming session hrs 5-60.10.10.10.3-0.30.3-0.20.20.30.1-0.00.2
Progressive ratio0.00.10.20.00.0-0.0-0.30.30.20.3-0.20.5
Food seeking constrained by brief footshock1.92.33.6-1.81.9-1.91.4-1.4-1.6-1.60.8-0.9
Seeking ratio, punishment vs. effort0.40.50.8-0.90.8-0.80.6-0.6-0.9-0.70.9-0.1
Retroperitoneal fat weight1.25.116.42.5-1.71.7-1.41.42.50.4-4.0-2.7
Reaction time number correct0.00.00.10.0-0.10.10.0-0.0-0.1-0.1-0.3-0.3
Reaction time mean minus median0.20.50.6-0.70.8-0.80.7-0.7-0.8-0.80.6-0.7
Reaction time mean minus median AUC0.51.31.6-1.01.1-1.11.2-1.2-1.2-1.30.7-1.2
Reaction time num false alarms0.50.71.20.9-1.01.0-0.70.70.61.1-0.10.9
Reaction time num false alarms AUC0.61.01.61.1-1.21.2-0.90.90.81.3-0.41.0
Reaction time trials correct on left0.00.00.10.0-0.10.10.0-0.0-0.1-0.1-0.3-0.3
Reaction time trials on left0.00.00.10.1-0.10.00.0-0.0-0.1-0.1-0.3-0.4
Reaction time mean0.30.40.9-0.50.6-0.60.6-0.6-0.9-0.50.8-0.4
Reaction time mean AUC0.20.30.5-0.40.5-0.50.5-0.5-0.7-0.40.6-0.5
Median of all reaction times0.10.10.3-0.20.2-0.20.2-0.2-0.6-0.10.5-0.1
Reaction time omissions0.10.10.80.3-0.10.00.2-0.20.1-0.2-0.5-0.9
Reaction time false alarm rate0.40.61.00.8-0.90.9-0.60.60.61.00.01.0
Reaction time premature initiation rate0.20.31.2-0.40.3-0.30.1-0.1-0.20.40.91.1
Reaction time premature initiations0.10.20.8-0.40.2-0.20.1-0.1-0.20.30.70.9
Std. dev. reaction times0.71.22.0-1.11.1-1.11.1-1.1-1.4-1.01.4-0.6
Reaction time trials completed0.00.00.10.1-0.10.00.0-0.0-0.1-0.1-0.3-0.4
Reaction time trials AUC0.00.10.30.3-0.20.2-0.10.10.1-0.1-0.6-0.6
Run reversals in cocaine runway, females0.90.91.5-1.11.0-1.01.0-1.0-1.2-0.71.1-0.0
Run reversals in cocaine runway, males1.31.45.91.0-0.40.4-0.10.10.9-0.3-2.4-2.0
Latency to leave start box in cocaine runway0.60.61.7-0.80.5-0.50.7-0.7-1.2-0.31.30.5
Latency to leave start box in cocaine runway, F0.30.31.0-0.50.1-0.10.2-0.2-0.70.21.01.0
Latency to leave start box in cocaine runway, M0.20.20.7-0.30.3-0.30.5-0.5-0.8-0.20.70.1
Std. dev. time between licks in bursts0.60.72.9-0.90.6-0.6-0.30.3-0.40.41.31.7
Total sessions with >9 infusions0.70.81.61.2-1.01.0-0.90.90.70.9-1.00.1
Short access day 1 total inactive lever presses1.72.27.5-1.50.9-0.90.8-0.8-1.60.12.72.2
Short access day 10 total inactive lever presses1.33.27.0-2.41.8-1.71.3-1.3-1.9-1.12.61.2
Short access day 1 total infusions0.10.10.2-0.00.0-0.0-0.20.2-0.30.20.40.5
Short access day 10 total infusions0.10.20.40.6-0.50.5-0.40.40.10.60.10.4
Short access total infusions0.40.50.91.0-0.80.7-0.80.80.40.8-0.40.4
Short access day 1 locomotion0.60.71.10.9-0.90.9-0.90.90.71.0-0.50.6
Short access day 10 total locomotion0.30.61.0-1.00.9-0.90.3-0.3-0.9-0.11.01.0
Short access total locomotion0.91.11.81.0-0.90.9-1.21.20.81.3-0.51.3
One hour access (0.3 mA shock)1.31.54.7-1.21.1-1.10.8-0.8-1.5-0.32.21.0
Compulsive drug intake0.30.41.5-0.50.3-0.2-0.10.1-0.30.41.11.2
One hour access (shock baseline)0.10.20.9-0.20.2-0.20.3-0.3-0.60.10.90.6
Social response proportion1.01.12.1-1.41.3-1.21.0-1.0-0.8-1.20.9-0.4
Social responses0.20.20.6-0.80.7-0.60.2-0.2-0.1-0.50.4-0.0
Social time2.43.24.8-2.21.9-1.91.7-1.7-1.9-1.62.2-0.3
Soleus weight0.10.20.40.5-0.50.5-0.30.30.60.2-0.5-0.3
Bone: stiffness1.22.02.7-1.51.4-1.41.6-1.6-1.4-1.51.1-0.7
Tibialis anterior weight0.20.82.70.9-0.70.7-0.20.20.8-0.3-1.2-1.6
Time to tail flick, vehicle, before self-admin0.20.20.30.4-0.40.4-0.50.50.20.60.30.5
Time to tail flick, vehicle, after self-admin0.10.10.2-0.40.5-0.50.1-0.1-0.1-0.40.2-0.2
Time to tail flick, test, before self-admin0.70.72.9-0.50.1-0.10.6-0.6-1.00.41.71.3
Time to tail flick, test, after self-admin0.20.20.40.3-0.30.3-0.40.40.60.3-0.40.3
Delta time to tail flick, vehicle, before/after SA0.50.50.8-0.80.9-0.90.6-0.6-0.6-0.70.2-0.5
Delta time to tail flick, test, before/after SA1.61.64.71.1-0.80.8-1.31.31.80.3-2.2-0.9
Tibia length2.56.910.0-2.62.6-2.63.2-3.2-2.7-2.81.7-1.8
Ambulatory time before self-admin0.10.10.2-0.40.3-0.3-0.00.0-0.2-0.20.50.5
Ambulatory time after self-admin3.64.25.8-2.42.4-2.42.1-2.1-2.2-2.11.3-0.8
Bone: tissue strength3.23.24.6-2.11.9-1.91.8-1.8-2.1-1.42.00.0
Total heroin consumption0.50.61.2-0.90.6-0.60.7-0.7-1.1-0.30.70.9
Bone: trabecular number1.32.13.1-1.51.5-1.51.8-1.8-1.5-1.50.8-1.1
Bone: trabecular spacing0.20.30.6-0.40.6-0.60.4-0.4-0.4-0.6-0.5-0.8
Bone: trabecular thickness0.00.00.00.1-0.20.20.2-0.2-0.20.10.2-0.1
Bone: trabecular tissue density2.02.96.22.2-1.81.7-1.41.41.80.8-2.5-1.2
Water consumed over 24 hours0.40.60.9-0.60.7-0.70.9-0.9-0.5-0.90.2-1.0
Number of responses in last shaping day0.30.30.8-0.40.5-0.50.5-0.5-0.9-0.30.70.0