Hub : Genes

Tyr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Tyr 0.02 0.01 1.0e-02 0.01 0.01 0.01 0.01 3.2e-02 1.3e-02 3.1e-02 3.6e-02
2 IC gene expression Tyr 0.14 0.1 4.6e-03 0.03 0.03 0.01 0.01 1.5e-02 2.9e-02 7.2e-02 8.9e-02
3 BLA gene expression Tyr 0.1 0.06 2.1e-03 0.06 0.04 0.01 0.05 3.3e-04 4.9e-03 8.8e-02 9.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.20.50.9-0.10.71.0
Area under the delay curve2.23.43.7-1.71.91.9
BMI with tail0.00.20.30.6-0.3-0.2
BMI without tail0.00.10.1-0.30.20.4
Body weight0.10.50.80.10.90.8
Weight adjusted by age0.10.20.30.6-0.3-0.3
Bone surface0.20.40.9-0.10.41.0
Bone volume0.10.30.6-0.00.50.8
Breakpoint value in progressive ratio session0.00.00.00.20.2-0.0
Number of licking bursts0.10.20.20.30.50.5
Context. condit. distance diff. score0.30.30.70.20.80.5
Locomotion velocity, session 15.86.513.0-3.61.71.9
Locomotion distance, session 10.10.10.1-0.1-0.4-0.3
Locomotion velocity, session 24.65.56.9-2.62.22.2
Locomotion distance, session 20.10.10.3-0.5-0.3-0.1
Locomotion velocity, session 32.83.23.8-1.91.71.7
Locomotion distance, session 38.59.811.9-3.52.93.0
Stereotopy head waving bouts, day 35.76.88.32.9-2.4-2.5
Stereotopy head waving duration, day 30.30.40.9-0.90.40.3
Locomotion velocity, session 72.93.25.5-2.31.31.5
Locomotion distance, session 72.53.13.6-1.91.61.8
Stereotopy head waving bouts, day 73.13.64.4-2.11.81.8
Stereotopy head waving duration, day 73.74.56.2-2.51.92.0
Locomotion velocity, session 83.84.65.8-2.42.11.9
Locomotion distance, session 80.10.10.30.60.0-0.1
Degree of sensitization distance2.72.93.92.0-1.6-1.5
Degree of sensitization stereotypy4.04.54.7-2.22.02.2
Conditioned locomotion3.54.15.21.6-2.3-2.1
Cocaine response after cond. corrected0.20.30.6-0.50.50.8
Cocaine response after cond. not corrected0.10.20.3-0.50.20.4
Cocaine response before conditioning0.20.30.40.4-0.5-0.6
Saline control response3.24.46.4-1.62.52.0
Bone: connectivity density0.40.61.30.00.71.1
Bone: cortical apparent density0.91.42.40.3-1.3-1.6
Bone: cortical area0.10.10.20.20.30.5
Bone: cortical porosity1.21.32.2-1.50.90.9
Bone: cortical porosity0.40.51.1-1.10.30.4
Bone: cortical thickness0.10.10.10.3-0.3-0.3
Bone: cortical thickness0.10.10.1-0.3-0.4-0.1
Bone: cortical tissue density0.91.42.50.3-1.3-1.6
Condit. Reinf. active minus inactive responses3.03.43.71.8-1.8-1.9
Condit. Reinf. active-inactive response ratio0.50.51.31.1-0.4-0.5
Condit. Reinf. active responses4.55.86.82.1-2.5-2.6
Condit. Reinf. inactive responses2.63.44.70.9-2.2-2.2
Incentive salience index mean1.21.51.71.1-1.3-1.3
Condit. Reinf. lever presses0.10.10.4-0.70.00.1
Condit. Reinf. active minus inactive responses0.50.71.20.1-1.0-1.1
Condit. Reinf. active-inactive response ratio2.03.14.40.8-2.1-2.1
Condit. Reinf. active responses0.10.20.3-0.2-0.5-0.6
Condit. Reinf. inactive responses1.21.72.2-0.91.51.5
Condit. Reinf. lever presses0.20.40.5-0.7-0.3-0.7
Condit. Reinf. lever reinforcers received0.10.10.2-0.2-0.3-0.4
Conditioned reinforcement - actives2.610.511.82.8-3.4-3.4
Conditioned reinforcement - inactives0.41.01.11.0-0.9-1.1
Conditioned locomotion3.95.87.41.8-2.7-2.6
Patch foraging indifference point 0 sec0.00.10.10.40.1-0.0
Patch foraging indifference point AUC0.61.31.7-0.91.31.2
Delay disc. indifference point, 0s delay0.10.10.40.6-0.20.2
Delay disc. indifference point, 16s delay2.23.14.1-2.01.71.5
Delay disc. indifference point, 2s delay1.21.42.1-0.81.21.5
Delay disc. indifference point, 24s delay1.62.63.3-1.81.71.3
Delay disc. indifference point, 4s delay1.61.72.6-0.61.41.6
Delay disc. indifference point, 8s delay0.81.41.5-1.21.21.1
Indifference point function ln k0.10.31.0-1.00.10.2
Indifference point function log k0.10.31.0-1.00.10.2
Patch foraging total patch changes 0 sec0.00.00.00.20.0-0.1
Patch foraging total patch changes 12 sec0.50.72.11.4-0.2-0.2
Patch foraging total patch changes 18 sec0.41.12.01.4-0.8-0.8
Patch foraging total patch changes 24 sec0.41.42.01.4-1.0-1.1
Patch foraging total patch changes 6 sec0.50.91.3-0.41.11.1
Patch foraging time to switch 0 sec0.51.94.42.1-0.9-0.7
Patch foraging water rate 0 sec0.51.92.9-1.71.21.2
Patch foraging water rate 12 sec0.72.86.2-2.51.10.9
Patch foraging water rate 18 sec3.17.013.0-3.62.02.1
Patch foraging water rate 24 sec1.01.52.0-1.41.21.0
Patch foraging water rate 6 sec1.11.63.2-1.80.90.9
Seeking ratio, delayed vs. immediate footshock0.10.20.2-0.50.40.4
Distance traveled before self-admin0.10.30.30.5-0.6-0.5
Distance traveled after self-admin0.10.20.50.7-0.1-0.1
Extensor digitorum longus weight0.00.00.10.3-0.10.0
Bone: elastic displacement0.20.20.30.5-0.4-0.6
Bone: elastic work0.20.20.30.3-0.6-0.5
Bone: endosteal estimation0.51.32.0-0.41.31.4
Bone: endosteal perimeter0.20.50.80.00.90.9
Epididymis fat weight0.10.51.41.2-0.2-0.3
Delta time in closed arm before/after self-admin1.91.82.0-1.41.31.3
Delta time in open arm before/after self-admin0.40.40.5-0.70.70.7
Diff in mean of infusions in LGA sessions1.01.82.5-1.01.61.4
Delay discount exponential model param2.33.13.41.6-1.9-1.9
Extinction: sum of active levers before priming0.71.11.11.0-1.0-1.1
Active lever presses in extinction session 63.03.03.61.5-1.9-1.8
Bone: final force0.30.50.90.10.90.9
Bone: final moment0.30.40.70.20.70.8
Food consumed during 24 hour testing period1.93.85.5-1.62.31.9
Glucose0.20.30.5-0.70.50.4
Heart weight0.10.20.5-0.1-0.5-0.7
Delay discount hyperbolic model param2.22.93.31.4-1.8-1.8
Intermittent access intake day 1-15 change0.52.53.31.2-1.7-1.8
Intermittent access intake escalation0.42.02.51.2-1.5-1.6
Intermittent access intake escalation 21.52.63.11.4-1.7-1.8
Intermitt. access day 1 inactive lever presses0.45.15.3-2.32.32.2
Intermitt. access day 15 inactive lever presses0.10.40.4-0.60.70.6
Intermitt. access escalation Index0.31.01.3-1.21.00.8
Intermittent access day 1 total infusions1.03.03.51.5-1.9-1.8
Intermittent access day 15 total infusions2.56.06.92.1-2.6-2.6
Intermittent access terminal intake (last 3 days)6.311.012.82.7-3.6-3.5
Intermittent access total infusions5.66.77.72.2-2.8-2.7
Intermittent access day 1 locomotion0.10.20.40.2-0.6-0.5
Intermittent access day 15 total locomotion0.20.91.20.3-1.1-1.1
Intermittent access total locomotion0.20.20.30.3-0.6-0.5
Intermittent access standard deviation0.94.74.82.2-2.2-2.1
Left kidney weight0.21.73.81.9-0.8-0.8
Right kidney weight0.10.40.90.90.40.4
Cocaine induced anxiety1.33.54.4-1.42.12.0
Post-drug Anxiety4.55.15.6-2.42.32.2
Baseline Anxiety1.62.76.7-2.60.80.8
Tail length0.42.22.4-1.41.51.5
Length with tail0.62.63.6-1.01.91.8
Length without tail0.21.11.7-0.31.21.3
Times rat made contact with spout0.70.81.0-1.00.71.0
Lifetime Intake7.18.89.92.6-3.1-3.1
Liver weight, left1.01.73.92.0-0.7-0.9
Liver weight, right0.10.30.30.50.40.6
Locomotor activity4.06.29.3-3.12.12.2
Locomotor testing distance1.12.65.1-2.31.21.1
Locomotor testing rearing0.31.02.2-1.50.70.6
Locomotion in novel chamber1.92.53.1-1.81.51.5
Locomotion in novel chamber post-restriction0.41.31.80.8-1.3-1.3
Fecal boli incidents, locomotor time 10.51.41.7-1.21.01.3
Change in fecal boli incidents, locomotor task0.30.30.40.4-0.5-0.6
Time >=10cm from walls, locomotor time 10.00.00.0-0.00.10.1
Bouts of movement, locomotor time 11.31.72.0-1.41.11.4
Total resting periods, locomotor time 10.91.01.2-1.10.81.1
Rest time, locomotor task time 10.20.40.7-0.30.50.8
Distance moved, locomotor task time 10.30.81.10.7-0.9-1.1
Vertical activity count, locomotor time 10.10.81.11.1-0.7-0.8
Time >=10cm from walls, locomotor time 20.41.01.4-0.81.01.2
Bouts of movement, locomotor time 20.51.72.1-1.41.31.1
Total resting periods, locomotor time 20.31.01.5-1.20.90.8
Rest time, locomotor task time 21.21.92.31.5-1.4-1.3
Distance moved, locomotor task time 20.10.20.50.7-0.2-0.1
Vertical activity count, locomotor time 20.40.82.11.5-0.4-0.5
Light reinforcement 12.210.017.94.2-2.5-2.4
Light reinforcement 27.516.927.45.2-3.3-3.5
Bone: marrow area0.51.21.9-0.41.31.4
Bone: maximum diameter0.10.20.50.00.50.7
Bone: maximum force0.30.50.9-0.10.81.0
Bone: maximum moment0.20.40.70.00.70.9
Mean time between licks in bursts1.06.06.52.6-2.4-2.3
Mean num. licks in bursts0.10.30.9-0.9-0.00.2
Cd content in liver1.41.62.01.4-1.2-1.1
Co content in liver0.20.20.6-0.8-0.2-0.2
Cu content in liver2.93.43.6-1.91.81.9
Fe content in liver0.40.50.70.8-0.6-0.7
K content in liver0.10.10.20.4-0.1-0.1
Mg content in liver2.12.32.8-1.21.61.7
Mn content in liver0.00.00.00.2-0.1-0.1
Na content in liver7.38.29.9-2.43.13.0
Rb content in liver0.40.50.80.20.70.9
Se content in liver0.40.50.7-0.40.80.8
Sr content in liver1.41.22.2-1.50.80.8
Zn content in liver0.10.10.2-0.20.40.5
Bone: minimum diameter0.30.61.00.30.91.0
Time in familiar zone, hab. session 10.10.10.30.5-0.4-0.2
Time in novel zone, hab. session 10.10.10.1-0.20.30.3
Total zone transitions, hab. session 12.83.95.1-2.21.62.1
Total locomotion distance, hab. session 117.925.538.76.2-4.5-4.2
Locomotion velocity, hab. session 120.729.441.76.5-5.0-4.7
Time in familiar zone, hab. session 20.20.20.40.20.30.6
Time in novel zone, hab. session 20.50.61.0-0.3-0.8-1.0
Total zone transitions, hab. session 21.31.73.1-1.80.71.2
Total locomotion distance, hab. session 223.230.343.26.6-4.9-4.9
Locomotion velocity, hab. session 222.229.743.16.6-4.8-4.8
Novel to familiar place preference ratio0.60.80.90.9-0.9-1.0
Novelty place preference0.60.81.00.8-0.9-1.0
Time in novel zone, NPP test0.70.81.00.8-1.0-1.0
Total zone transitions, NPP test0.30.51.3-1.2-0.10.2
Total locomotion distance, NPP test29.541.254.37.4-5.9-5.9
Locomotion velocity, NPP test28.440.554.17.4-5.8-5.8
Intraocular pressure2.54.29.1-3.01.31.3
Delta distance traveled before/after self-admin0.20.20.30.20.50.5
Delta ambulatory time before/after self-admin0.10.10.20.50.30.2
Parametrial fat weight0.10.20.3-0.50.40.1
Pavlov. Cond. lever latency1.62.02.41.6-1.4-1.2
Pavlov. Cond. magazine entry latency0.00.10.1-0.3-0.2-0.2
Pavlov. Cond. change in total contacts0.50.50.8-0.40.90.7
Pavlov. Cond. index score0.50.60.9-0.90.70.7
Pavlov. Cond. latency score0.40.60.9-0.90.70.6
Pavlov. Cond. lever contacts1.11.31.5-1.21.21.0
Pavlov. Cond. magazine entry number0.10.10.20.50.0-0.1
Pavlov. Cond. intertrial magazine entries0.20.20.2-0.50.40.5
Pavlov. Cond. lever-magazine prob. diff.1.01.21.3-1.11.11.1
Pavlov. Cond. response bias0.10.10.2-0.40.30.3
Pavlov. Cond. lever latency0.60.81.50.30.91.2
Pavlov. Cond. magazine entry latency0.00.10.2-0.4-0.1-0.1
Pavlov. Cond. change in total contacts0.41.01.70.4-1.3-1.1
Pavlov. Cond. index score0.30.40.7-0.3-0.7-0.8
Pavlov. Cond. latency score0.20.30.4-0.4-0.5-0.7
Pavlov. Cond. lever contacts0.40.61.1-0.4-0.8-1.1
Pavlov. Cond. magazine entry number0.20.30.90.9-0.2-0.1
Pavlov. Cond. intertrial magazine entries0.30.70.7-0.90.80.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.3-0.7-0.8
Pavlov. Cond. response bias0.50.71.1-0.5-0.8-1.0
Time in closed arm before self-admin0.10.20.40.6-0.5-0.2
Time in closed arm after self-admin0.10.10.20.3-0.5-0.1
Time in open arm before self-admin0.00.00.0-0.2-0.00.1
Time in open arm after self-admin1.11.21.4-1.11.21.1
Bone: periosteal estimation0.61.42.2-0.41.31.5
Bone: periosteal perimeter0.20.30.5-0.20.70.7
Bone: post-yield work1.01.72.4-1.11.31.6
Progressive ratio test 1 active lever presses1.42.53.41.1-1.8-1.7
Progressive ratio test 1 breakpoint1.42.53.41.1-1.8-1.7
Progressive ratio test 1 inactive lever presses0.00.10.1-0.1-0.3-0.2
Progressive ratio test 2 active lever presses0.91.31.80.6-1.4-1.3
Progressive ratio test 2 breakpoint1.01.31.90.6-1.4-1.3
Progressive ratio test 2 inactive lever presses0.61.82.50.8-1.6-1.5
Incentive Sensitization - Responses0.00.00.0-0.20.0-0.0
Incentive Sensitization - Breakpoint0.00.00.10.0-0.2-0.3
Sum of active levers in priming session hrs 5-610.49.810.53.0-3.1-3.2
Progressive ratio0.71.92.90.9-1.7-1.5
Food seeking constrained by brief footshock1.31.72.01.2-1.4-1.3
Seeking ratio, punishment vs. effort0.00.10.10.30.30.2
Retroperitoneal fat weight0.10.41.11.10.30.3
Reaction time number correct0.00.10.2-0.40.20.4
Reaction time mean minus median0.00.10.20.0-0.4-0.3
Reaction time mean minus median AUC0.10.40.70.3-0.8-0.6
Reaction time num false alarms4.17.010.63.3-2.3-2.2
Reaction time num false alarms AUC2.35.48.02.8-2.1-2.0
Reaction time trials correct on left0.00.10.2-0.40.20.4
Reaction time trials on left0.00.10.2-0.40.20.4
Reaction time mean0.30.71.31.1-0.5-0.6
Reaction time mean AUC0.10.30.70.8-0.2-0.2
Median of all reaction times0.50.81.91.4-0.4-0.5
Reaction time omissions0.10.10.20.40.20.4
Reaction time false alarm rate3.54.87.22.7-1.9-1.9
Reaction time premature initiation rate0.20.30.5-0.40.70.5
Reaction time premature initiations0.10.30.4-0.50.60.5
Std. dev. reaction times0.00.00.1-0.3-0.00.1
Reaction time trials completed0.00.10.2-0.40.20.4
Reaction time trials AUC0.00.10.1-0.20.10.3
Run reversals in cocaine runway, females0.20.20.20.5-0.4-0.5
Run reversals in cocaine runway, males0.80.91.30.3-1.1-1.2
Latency to leave start box in cocaine runway0.50.72.01.4-0.3-0.1
Latency to leave start box in cocaine runway, F0.20.20.50.7-0.00.3
Latency to leave start box in cocaine runway, M2.22.14.02.0-1.0-1.1
Std. dev. time between licks in bursts0.30.51.61.2-0.1-0.2
Total sessions with >9 infusions12.515.617.03.7-4.1-4.0
Short access day 1 total inactive lever presses0.00.00.0-0.00.1-0.1
Short access day 10 total inactive lever presses1.17.59.8-2.03.13.0
Short access day 1 total infusions5.510.911.33.2-3.4-3.3
Short access day 10 total infusions2.23.74.41.7-2.1-1.9
Short access total infusions6.28.79.52.8-3.1-3.0
Short access day 1 locomotion0.81.31.61.2-1.1-1.1
Short access day 10 total locomotion0.10.40.5-0.70.60.6
Short access total locomotion1.82.73.11.4-1.8-1.7
One hour access (0.3 mA shock)4.75.57.01.7-2.6-2.6
Compulsive drug intake0.30.50.80.3-0.8-0.9
One hour access (shock baseline)1.02.73.41.3-1.9-1.8
Social response proportion0.00.00.1-0.20.0-0.0
Social responses0.00.00.00.10.1-0.0
Social time0.91.52.70.31.31.6
Soleus weight0.10.40.40.6-0.6-0.6
Bone: stiffness0.10.20.40.50.30.6
Tibialis anterior weight0.20.71.51.2-0.4-0.6
Time to tail flick, vehicle, before self-admin0.20.20.5-0.7-0.2-0.2
Time to tail flick, vehicle, after self-admin1.73.43.6-1.81.91.8
Time to tail flick, test, before self-admin1.21.31.5-1.21.11.2
Time to tail flick, test, after self-admin2.42.52.9-1.71.61.5
Delta time to tail flick, vehicle, before/after SA2.72.93.8-1.31.91.9
Delta time to tail flick, test, before/after SA0.10.20.30.6-0.2-0.4
Tibia length0.51.41.7-1.01.31.2
Ambulatory time before self-admin0.20.70.90.7-0.9-0.8
Ambulatory time after self-admin0.20.30.80.9-0.1-0.1
Bone: tissue strength0.20.20.20.40.50.4
Total heroin consumption0.40.50.50.7-0.7-0.7
Bone: trabecular number0.20.50.90.10.61.0
Bone: trabecular spacing1.01.42.3-1.51.10.8
Bone: trabecular thickness1.11.52.01.0-1.4-1.2
Bone: trabecular tissue density0.30.60.90.0-1.0-0.9
Water consumed over 24 hours0.71.41.6-1.31.11.2
Number of responses in last shaping day0.10.10.20.10.40.4