Hub : Genes

Tut4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Tut4	0.04	0.03	4.1e-07	0.04	0.03	0.03	0.03	2.6e-06	7.6e-06	1.4e-05	9.0e-06
2	PL	intron excision ratio	chr5_128432435_128450844	0.02	0.02	8.7e-03	0.02	0.02	0.01	0.02	3.3e-03	5.4e-03	2.2e-02	3.0e-03
3	Adipose	gene expression	Tut4	0.08	0.05	4.6e-07	0.04	0.03	0.03	0.03	2.3e-05	2.0e-04	6.4e-04	1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.6	1.0	1.1	1.0	-1.1	-1.0
Area under the delay curve	0.0	0.0	0.0	-0.1	0.1	-0.2
BMI with tail	1.5	5.3	6.5	-2.2	2.1	2.6
BMI without tail	0.8	2.5	2.7	-1.6	1.5	1.7
Body weight	0.8	3.7	4.2	-1.9	1.8	2.1
Weight adjusted by age	0.1	0.2	0.2	-0.4	0.4	0.5
Bone surface	0.2	0.3	0.5	0.5	-0.5	-0.7
Bone volume	0.0	0.0	0.0	0.1	-0.2	-0.2
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.4	-0.2	-0.2
Number of licking bursts	0.1	0.1	0.3	0.1	0.2	0.5
Context. condit. distance diff. score	0.5	0.6	0.8	0.9	-0.8	-0.5
Locomotion velocity, session 1	3.9	4.2	4.7	2.2	-2.2	-1.8
Locomotion distance, session 1	0.1	0.1	0.3	0.5	-0.4	-0.1
Locomotion velocity, session 2	3.8	4.4	5.4	2.3	-2.2	-1.8
Locomotion distance, session 2	0.9	1.2	1.6	-1.1	1.3	0.9
Locomotion velocity, session 3	0.7	0.9	1.0	1.0	-0.9	-0.9
Locomotion distance, session 3	0.3	0.3	0.5	-0.7	0.6	0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.5	-0.3	0.0
Stereotopy head waving duration, day 3	0.6	0.8	1.2	1.1	-1.0	-0.3
Locomotion velocity, session 7	0.1	0.1	0.1	-0.4	0.3	-0.3
Locomotion distance, session 7	0.4	0.5	0.8	-0.8	0.9	-0.3
Stereotopy head waving bouts, day 7	1.9	2.2	2.7	1.6	-1.5	-1.2
Stereotopy head waving duration, day 7	2.0	2.4	3.1	1.7	-1.6	-1.2
Locomotion velocity, session 8	1.9	2.3	2.5	1.4	-1.5	-1.6
Locomotion distance, session 8	0.0	0.0	0.0	0.1	0.0	-0.1
Degree of sensitization distance	0.1	0.1	0.3	-0.3	0.5	0.1
Degree of sensitization stereotypy	0.9	1.0	1.3	1.2	-1.0	-0.8
Conditioned locomotion	0.1	0.1	0.2	0.4	-0.2	0.4
Cocaine response after cond. corrected	2.8	3.4	4.3	-2.1	2.0	1.5
Cocaine response after cond. not corrected	3.3	3.9	4.5	-2.1	2.0	1.8
Cocaine response before conditioning	0.0	0.0	0.1	0.0	-0.1	0.3
Saline control response	0.3	0.5	0.8	-0.8	0.9	-0.1
Bone: connectivity density	1.0	1.5	2.0	1.1	-1.1	-1.4
Bone: cortical apparent density	2.3	3.2	3.5	1.9	-1.9	-1.6
Bone: cortical area	1.4	2.2	2.5	-1.6	1.5	1.3
Bone: cortical porosity	0.7	0.7	1.2	1.1	-1.0	-0.0
Bone: cortical porosity	1.1	1.2	1.9	1.4	-1.3	-0.4
Bone: cortical thickness	2.6	4.4	4.9	-2.0	2.0	2.2
Bone: cortical thickness	1.5	1.8	2.6	-1.2	1.2	1.6
Bone: cortical tissue density	2.6	3.6	4.0	2.0	-2.0	-1.6
Condit. Reinf. active minus inactive responses	0.6	0.6	0.7	-0.7	0.8	0.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	0.9	-0.8	0.9	0.9
Condit. Reinf. active responses	1.1	1.4	1.5	-1.1	1.2	1.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.4	0.2
Incentive salience index mean	1.7	2.1	2.5	-1.3	1.5	1.6
Condit. Reinf. lever presses	1.7	2.4	2.9	-1.4	1.6	1.7
Condit. Reinf. active minus inactive responses	0.7	0.9	1.4	-1.2	1.1	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.6	0.5	0.0
Condit. Reinf. active responses	0.5	0.6	1.0	-1.0	0.8	0.5
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	0.5	0.7
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.3	0.3	-0.6
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	-1.0	0.8	0.3
Conditioned reinforcement - actives	2.3	3.9	4.9	-1.9	2.2	1.8
Conditioned reinforcement - inactives	0.1	0.1	0.1	-0.0	0.3	0.4
Conditioned locomotion	0.9	1.2	1.6	-1.0	1.3	1.0
Patch foraging indifference point 0 sec	0.4	0.8	0.9	-1.0	0.8	0.8
Patch foraging indifference point AUC	0.2	0.3	0.4	0.6	-0.5	-0.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.3	-0.2	-0.6
Delay disc. indifference point, 16s delay	1.1	1.3	1.4	-1.2	1.2	1.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.2	-0.2	-0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.3	-0.4	-0.5
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.2	0.3	0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.2	0.2	-0.1
Indifference point function ln k	0.4	0.7	0.8	-0.9	0.8	0.8
Indifference point function log k	0.4	0.7	0.8	-0.9	0.8	0.8
Patch foraging total patch changes 0 sec	0.3	0.6	0.7	-0.8	0.7	0.8
Patch foraging total patch changes 12 sec	1.0	1.3	1.4	1.2	-1.1	-1.2
Patch foraging total patch changes 18 sec	0.2	0.3	0.4	-0.5	0.6	0.6
Patch foraging total patch changes 24 sec	0.8	1.3	1.5	-1.2	1.0	1.2
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.7	0.6	0.3
Patch foraging time to switch 0 sec	1.1	2.3	2.8	1.7	-1.6	-1.3
Patch foraging water rate 0 sec	1.6	3.3	3.6	-1.9	1.7	1.8
Patch foraging water rate 12 sec	2.3	4.7	5.9	-2.4	2.1	2.0
Patch foraging water rate 18 sec	0.0	0.0	0.1	0.1	-0.3	-0.0
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.1	-0.0	0.2
Patch foraging water rate 6 sec	1.3	1.9	2.3	-1.5	1.3	1.4
Seeking ratio, delayed vs. immediate footshock	2.9	3.5	3.8	-1.7	2.0	1.9
Distance traveled before self-admin	0.0	0.0	0.1	-0.0	0.0	0.3
Distance traveled after self-admin	0.6	0.8	1.0	-0.8	0.8	1.0
Extensor digitorum longus weight	0.9	3.6	5.7	-1.6	1.7	2.4
Bone: elastic displacement	0.1	0.1	0.1	0.3	-0.3	0.4
Bone: elastic work	0.1	0.1	0.2	-0.4	0.2	0.5
Bone: endosteal estimation	0.1	0.2	0.3	0.3	-0.4	-0.5
Bone: endosteal perimeter	0.1	0.3	0.7	0.2	-0.2	-0.8
Epididymis fat weight	0.0	0.1	0.3	0.1	-0.2	-0.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.2	0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.2	0.4	0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.3	0.3	0.0
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.1	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	-0.0	0.4
Active lever presses in extinction session 6	1.7	1.7	1.8	-1.3	1.3	1.2
Bone: final force	0.0	0.0	0.1	-0.2	0.0	-0.3
Bone: final moment	0.0	0.1	0.1	-0.4	0.2	-0.1
Food consumed during 24 hour testing period	1.0	1.4	2.1	-1.4	1.4	0.3
Glucose	0.2	0.4	0.5	-0.7	0.7	0.4
Heart weight	1.1	1.7	2.6	-1.2	1.0	1.6
Delay discount hyperbolic model param	0.0	0.0	0.1	0.0	-0.0	0.3
Intermittent access intake day 1-15 change	0.4	0.9	1.1	-0.8	1.0	1.0
Intermittent access intake escalation	0.4	0.8	1.0	-0.7	1.0	1.0
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.3	0.5	0.5
Intermitt. access day 1 inactive lever presses	0.6	2.1	2.4	-1.4	1.5	1.4
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.0	-0.4	0.8	1.0
Intermitt. access escalation Index	0.1	0.1	0.1	-0.1	-0.4	-0.3
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.5	-0.3	-0.0
Intermittent access day 15 total infusions	0.2	0.3	0.6	-0.1	0.5	0.8
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	0.1	0.2	0.4
Intermittent access total infusions	0.0	0.0	0.1	0.3	-0.1	0.1
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.3	-0.2	0.0
Intermittent access day 15 total locomotion	0.2	0.3	0.4	-0.4	0.7	0.5
Intermittent access total locomotion	0.0	0.0	0.1	0.2	0.0	0.2
Intermittent access standard deviation	1.6	3.3	3.5	-1.7	1.9	1.9
Left kidney weight	5.8	26.8	27.4	-5.2	5.2	5.1
Right kidney weight	3.4	15.4	16.1	-3.9	3.8	4.0
Cocaine induced anxiety	0.4	0.5	0.7	-0.6	0.6	0.8
Post-drug Anxiety	0.6	0.7	0.7	-0.8	0.8	0.8
Baseline Anxiety	0.1	0.1	0.2	-0.4	0.4	0.1
Tail length	0.0	0.0	0.0	0.2	-0.1	-0.1
Length with tail	0.2	0.7	0.9	-0.9	1.0	0.8
Length without tail	1.7	5.5	6.2	-2.5	2.5	2.1
Times rat made contact with spout	0.8	0.9	1.7	-1.0	1.3	0.5
Lifetime Intake	0.0	0.0	0.0	0.1	-0.1	0.0
Liver weight, left	0.0	0.1	0.2	0.1	-0.1	-0.4
Liver weight, right	0.1	0.1	0.3	0.2	-0.1	-0.6
Locomotor activity	0.2	0.3	0.5	-0.7	0.7	0.0
Locomotor testing distance	0.6	1.0	1.5	-1.2	1.2	0.5
Locomotor testing rearing	0.4	0.9	1.4	-1.2	1.1	0.2
Locomotion in novel chamber	4.0	5.1	5.6	-2.4	2.3	2.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	0.0	0.1	0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.4	0.3	0.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	0.6	-0.5	-0.5
Time >=10cm from walls, locomotor time 1	1.6	1.7	2.1	1.4	-1.4	-0.9
Bouts of movement, locomotor time 1	0.7	0.8	1.1	1.0	-0.7	-0.9
Total resting periods, locomotor time 1	0.6	0.6	0.9	0.9	-0.6	-0.8
Rest time, locomotor task time 1	0.0	0.0	0.1	0.1	-0.0	-0.3
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.7	-0.7	-0.3
Vertical activity count, locomotor time 1	0.1	0.3	0.4	-0.5	0.5	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.0	-0.4	-0.1
Bouts of movement, locomotor time 2	0.5	0.8	1.2	1.1	-0.9	-0.6
Total resting periods, locomotor time 2	0.4	0.7	1.1	1.0	-0.8	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.2	0.3	-0.1	-0.4
Distance moved, locomotor task time 2	0.5	0.6	0.8	-0.7	0.7	0.9
Vertical activity count, locomotor time 2	1.6	2.2	2.6	-1.4	1.6	1.5
Light reinforcement 1	0.1	0.2	0.4	-0.3	0.1	0.6
Light reinforcement 2	1.0	1.6	2.1	-1.1	1.1	1.4
Bone: marrow area	0.0	0.1	0.2	0.2	-0.3	-0.4
Bone: maximum diameter	0.1	0.1	0.2	-0.3	0.3	0.4
Bone: maximum force	0.0	0.0	0.1	-0.3	0.1	-0.2
Bone: maximum moment	0.1	0.1	0.2	-0.4	0.3	-0.0
Mean time between licks in bursts	0.6	1.5	2.7	0.9	-1.0	-1.6
Mean num. licks in bursts	0.5	0.8	1.2	-1.1	1.0	0.4
Cd content in liver	0.6	0.6	0.8	0.7	-0.7	-0.9
Co content in liver	0.0	0.0	0.0	-0.1	0.1	-0.2
Cu content in liver	0.2	0.3	0.5	-0.4	0.3	-0.7
Fe content in liver	0.4	0.5	0.9	-0.5	0.4	0.9
K content in liver	0.3	0.3	0.5	-0.3	0.4	-0.7
Mg content in liver	2.0	2.0	2.9	-1.6	1.7	0.6
Mn content in liver	0.3	0.3	0.4	0.6	-0.6	-0.6
Na content in liver	0.3	0.4	0.7	0.5	-0.4	-0.8
Rb content in liver	0.1	0.1	0.1	-0.3	0.3	-0.2
Se content in liver	0.1	0.1	0.2	-0.1	0.1	-0.5
Sr content in liver	0.0	0.0	0.0	0.1	-0.1	0.0
Zn content in liver	0.4	0.4	1.2	0.1	-0.1	-1.1
Bone: minimum diameter	0.7	1.3	1.8	-1.4	1.3	0.5
Time in familiar zone, hab. session 1	0.4	0.4	0.7	0.5	-0.8	-0.6
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.2	0.2	-0.3
Total zone transitions, hab. session 1	0.2	0.3	0.5	0.7	-0.6	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.0	-0.0	0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.1	-0.1	0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.7	-0.0	-0.0	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.1	-0.2	0.4
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.4	0.0
Total locomotion distance, hab. session 2	0.4	0.5	0.7	-0.9	0.7	0.6
Locomotion velocity, hab. session 2	0.5	0.6	0.7	-0.8	0.7	0.8
Novel to familiar place preference ratio	1.8	1.9	2.5	-1.5	1.6	1.1
Novelty place preference	0.9	1.0	1.3	-1.0	1.2	0.8
Time in novel zone, NPP test	0.7	0.8	1.0	-0.9	1.0	0.6
Total zone transitions, NPP test	0.5	0.7	1.1	-0.7	0.7	1.1
Total locomotion distance, NPP test	0.8	1.1	1.5	-0.9	0.9	1.2
Locomotion velocity, NPP test	1.3	1.8	2.4	-1.2	1.2	1.6
Intraocular pressure	0.3	0.5	0.6	-0.8	0.7	0.5
Delta distance traveled before/after self-admin	1.7	1.8	2.1	-1.4	1.4	1.2
Delta ambulatory time before/after self-admin	1.0	1.2	1.4	-1.2	1.1	1.0
Parametrial fat weight	0.0	0.0	0.1	0.0	-0.3	-0.1
Pavlov. Cond. lever latency	1.6	2.0	3.0	1.1	-1.3	-1.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.5	-0.4	-0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	0.1	0.2
Pavlov. Cond. index score	0.3	0.4	0.6	-0.4	0.6	0.8
Pavlov. Cond. latency score	0.4	0.5	0.8	-0.5	0.8	0.9
Pavlov. Cond. lever contacts	1.2	1.4	2.2	-0.8	1.1	1.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.6	0.5	0.5
Pavlov. Cond. intertrial magazine entries	1.3	1.5	2.2	-1.5	1.3	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.6	0.8	0.9
Pavlov. Cond. response bias	0.1	0.1	0.2	0.0	0.2	0.4
Pavlov. Cond. lever latency	0.6	0.8	1.3	1.2	-0.9	0.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.7	-0.1	0.1	-1.3
Pavlov. Cond. change in total contacts	0.3	0.6	0.8	-0.9	0.8	-0.5
Pavlov. Cond. index score	0.4	0.6	0.9	-0.7	0.6	-1.0
Pavlov. Cond. latency score	0.4	0.6	0.8	-0.7	0.6	-0.9
Pavlov. Cond. lever contacts	0.4	0.6	1.0	-1.0	0.8	-0.3
Pavlov. Cond. magazine entry number	1.0	1.2	3.3	-0.4	0.4	1.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	0.8	-0.7	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.0	-0.7	0.6	-1.0
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.6	0.4	-0.9
Time in closed arm before self-admin	0.4	0.5	0.6	0.8	-0.7	-0.7
Time in closed arm after self-admin	0.2	0.2	0.3	0.4	-0.5	-0.4
Time in open arm before self-admin	0.1	0.1	0.1	-0.4	0.2	0.0
Time in open arm after self-admin	0.8	0.9	1.1	-0.9	1.0	0.9
Bone: periosteal estimation	0.3	0.6	0.7	-0.8	0.7	0.7
Bone: periosteal perimeter	0.1	0.2	0.3	-0.5	0.4	0.1
Bone: post-yield work	0.0	0.1	0.1	0.2	-0.2	-0.3
Progressive ratio test 1 active lever presses	0.6	0.8	1.1	-0.7	0.8	1.1
Progressive ratio test 1 breakpoint	0.6	0.8	1.1	-0.7	0.8	1.1
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.7	-0.4	0.6	0.8
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	-0.4	0.7	1.0
Progressive ratio test 2 breakpoint	0.5	0.5	1.0	-0.4	0.6	1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.1	0.3	0.5
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	0.1	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.0	0.1	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.0	0.1	0.4
Progressive ratio	0.2	0.3	0.5	-0.6	0.7	0.4
Food seeking constrained by brief footshock	3.3	4.1	4.6	2.1	-2.0	-1.9
Seeking ratio, punishment vs. effort	3.0	4.3	4.7	2.2	-2.2	-1.9
Retroperitoneal fat weight	0.1	0.3	0.4	0.5	-0.6	-0.5
Reaction time number correct	0.1	0.2	0.3	0.4	-0.5	0.0
Reaction time mean minus median	0.1	0.2	0.3	-0.4	0.5	-0.5
Reaction time mean minus median AUC	0.1	0.2	0.3	-0.3	0.3	-0.6
Reaction time num false alarms	1.5	2.1	2.8	-1.6	1.7	1.0
Reaction time num false alarms AUC	2.4	3.7	4.8	-2.1	2.2	1.4
Reaction time trials correct on left	0.1	0.2	0.3	0.4	-0.5	0.0
Reaction time trials on left	0.1	0.1	0.2	0.4	-0.5	0.0
Reaction time mean	0.1	0.2	0.5	0.0	0.2	-0.7
Reaction time mean AUC	0.2	0.3	0.8	0.3	-0.1	-0.9
Median of all reaction times	0.2	0.2	0.6	0.3	-0.1	-0.8
Reaction time omissions	0.5	0.7	1.2	-1.0	1.1	0.1
Reaction time false alarm rate	2.9	4.0	5.3	-2.2	2.3	1.4
Reaction time premature initiation rate	0.0	0.1	0.1	0.2	-0.1	-0.4
Reaction time premature initiations	0.1	0.2	0.2	0.5	-0.4	-0.5
Std. dev. reaction times	0.2	0.4	0.6	-0.6	0.8	-0.4
Reaction time trials completed	0.1	0.1	0.2	0.4	-0.5	0.0
Reaction time trials AUC	0.0	0.0	0.1	0.1	-0.3	0.2
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.2	-0.1	-0.3
Run reversals in cocaine runway, males	2.6	2.6	3.0	-1.7	1.7	1.4
Latency to leave start box in cocaine runway	0.7	0.8	1.3	-0.7	0.8	1.2
Latency to leave start box in cocaine runway, F	1.2	1.4	2.3	-0.9	1.0	1.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	-0.1	-0.2
Std. dev. time between licks in bursts	1.9	2.6	3.7	1.4	-1.5	-1.9
Total sessions with >9 infusions	0.0	0.0	0.0	0.0	0.0	-0.1
Short access day 1 total inactive lever presses	1.7	2.2	2.5	-1.5	1.4	1.6
Short access day 10 total inactive lever presses	0.1	0.3	0.3	-0.5	0.5	0.5
Short access day 1 total infusions	0.0	0.0	0.0	-0.2	0.0	0.1
Short access day 10 total infusions	0.0	0.1	0.2	-0.1	0.1	0.4
Short access total infusions	0.0	0.0	0.1	0.1	-0.2	-0.2
Short access day 1 locomotion	1.2	1.5	1.8	-1.2	1.3	1.1
Short access day 10 total locomotion	0.4	0.7	0.7	-0.8	0.8	0.8
Short access total locomotion	0.0	0.1	0.1	0.3	-0.2	-0.2
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.5	-0.2	-0.1
Compulsive drug intake	0.8	1.0	1.2	0.9	-1.1	-0.9
One hour access (shock baseline)	1.0	1.5	1.7	-1.0	1.3	1.3
Social response proportion	0.1	0.1	0.3	0.3	-0.2	-0.5
Social responses	1.0	1.3	1.8	1.0	-1.1	-1.3
Social time	0.2	0.2	0.5	-0.7	0.3	0.1
Soleus weight	3.0	8.7	9.7	-2.8	2.9	3.1
Bone: stiffness	0.0	0.0	0.0	-0.1	0.0	-0.2
Tibialis anterior weight	2.9	9.8	16.0	-2.6	2.6	4.0
Time to tail flick, vehicle, before self-admin	2.2	2.3	2.8	-1.4	1.4	1.7
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.8	-0.9	0.5	0.8
Time to tail flick, test, before self-admin	1.8	1.9	3.2	-1.2	1.0	1.8
Time to tail flick, test, after self-admin	0.8	0.8	1.0	-1.0	0.7	1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.1	-0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.0	-0.1	-0.5
Tibia length	0.1	0.4	0.6	-0.7	0.6	0.5
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.1	0.1
Ambulatory time after self-admin	0.4	0.4	0.6	-0.6	0.5	0.7
Bone: tissue strength	0.5	0.5	1.2	0.5	-0.5	-1.1
Total heroin consumption	0.5	0.6	0.6	0.8	-0.8	-0.7
Bone: trabecular number	0.7	1.1	1.4	0.9	-1.1	-1.2
Bone: trabecular spacing	1.0	1.4	1.9	-1.1	1.0	1.4
Bone: trabecular thickness	0.4	0.5	0.9	0.6	-0.5	-0.9
Bone: trabecular tissue density	0.4	0.6	0.9	1.0	-0.9	-0.4
Water consumed over 24 hours	1.3	1.7	2.5	-1.4	1.6	0.9
Number of responses in last shaping day	3.0	3.3	3.8	-2.0	1.8	1.7