Tubb5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Tubb5	0.12	0.07	1.0e-09	0.08	0.09	0.08	0.08	1.4e-09	2.0e-10	4.7e-09	1.4e-09
2	NAcc	gene expression	Tubb5	0.08	0.05	3.3e-08	0.07	0.07	0.07	0.07	3.5e-08	3.1e-08	2.3e-08	2.2e-08
3	Liver	gene expression	Tubb5	0.1	0.06	5.2e-08	0.03	0.04	0.05	0.05	5.5e-04	1.7e-05	1.6e-06	3.6e-06
4	pVTA	gene expression	Tubb5	0.18	0.12	1.5e-04	0.07	0.04	0.03	0.06	5.5e-04	1.2e-02	1.3e-02	1.9e-03
5	Adipose	gene expression	Tubb5	0.35	0.14	0.0e+00	0.32	0.33	0.33	0.33	8.3e-37	4.0e-37	1.1e-37	6.7e-38

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.4	2.4	4.8	1.5	-0.7	-2.2	1.7	-1.3
Area under the delay curve	1.2	1.2	2.1	0.3	1.2	1.2	-1.0	1.4
BMI with tail	1.3	4.4	7.6	0.4	2.6	0.9	-2.5	2.8
BMI without tail	2.3	4.8	8.4	-0.6	2.3	1.6	-2.9	2.7
Body weight	4.2	17.8	30.5	-1.8	4.3	3.2	-5.5	5.1
Weight adjusted by age	2.5	2.9	4.0	-1.1	1.4	2.0	-2.0	1.8
Bone surface	0.1	0.2	0.5	-0.7	-0.0	0.6	-0.4	0.1
Bone volume	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2	0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.3	0.1	-0.9	-0.2	1.1	-1.1
Number of licking bursts	0.8	0.9	1.3	-1.1	-1.0	1.1	0.4	-0.9
Context. condit. distance diff. score	5.4	6.5	11.9	-1.8	-3.4	-0.1	2.6	-3.2
Locomotion velocity, session 1	0.3	0.3	0.5	-0.6	-0.7	-0.2	0.4	-0.5
Locomotion distance, session 1	0.6	0.8	1.6	1.3	0.0	-1.2	0.8	-0.3
Locomotion velocity, session 2	0.1	0.1	0.3	-0.6	-0.3	0.4	-0.0	-0.3
Locomotion distance, session 2	0.3	0.5	0.7	0.4	-0.5	-0.9	0.8	-0.7
Locomotion velocity, session 3	0.4	0.4	0.9	0.9	0.6	-0.7	-0.2	0.6
Locomotion distance, session 3	1.3	1.4	1.9	0.6	-1.2	-1.4	1.3	-1.2
Stereotopy head waving bouts, day 3	1.5	1.8	3.0	-1.5	0.6	1.7	-1.6	1.0
Stereotopy head waving duration, day 3	1.0	1.2	1.9	-1.1	0.6	1.4	-1.3	1.0
Locomotion velocity, session 7	3.2	3.6	5.6	0.3	-2.1	-1.5	2.4	-2.3
Locomotion distance, session 7	2.9	3.7	6.5	0.9	-1.8	-1.6	2.5	-2.3
Stereotopy head waving bouts, day 7	1.5	1.7	3.0	-0.3	1.5	0.8	-1.7	1.5
Stereotopy head waving duration, day 7	2.0	2.4	4.6	-0.6	1.7	1.1	-2.1	1.8
Locomotion velocity, session 8	2.7	3.2	8.3	-2.9	-1.6	1.9	-0.1	-1.1
Locomotion distance, session 8	3.0	4.4	7.7	-1.3	-2.8	-0.4	2.2	-2.8
Degree of sensitization distance	0.7	0.8	0.9	-0.9	-0.9	0.9	0.7	-0.9
Degree of sensitization stereotypy	0.9	1.0	1.8	-0.1	1.3	0.6	-1.4	1.1
Conditioned locomotion	0.5	0.6	1.1	-0.8	0.1	0.9	-1.0	0.7
Cocaine response after cond. corrected	0.3	0.3	0.6	0.3	-0.6	-0.1	0.8	-0.8
Cocaine response after cond. not corrected	0.6	0.7	2.0	-1.0	-0.3	1.4	-0.4	-0.1
Cocaine response before conditioning	3.9	4.7	7.2	-2.1	1.2	2.7	-2.6	1.9
Saline control response	1.7	2.2	3.3	1.4	1.8	-1.0	-1.2	1.8
Bone: connectivity density	2.1	3.2	5.0	0.6	-1.8	-1.9	2.2	-2.0
Bone: cortical apparent density	1.2	1.6	3.2	1.8	1.5	-0.9	-0.4	1.2
Bone: cortical area	1.4	2.1	3.4	-0.3	1.7	1.2	-1.9	1.6
Bone: cortical porosity	0.5	0.5	1.0	0.5	1.0	0.5	-0.6	0.9
Bone: cortical porosity	0.6	0.6	1.4	-0.6	0.5	1.2	-0.8	0.7
Bone: cortical thickness	3.1	5.2	10.6	2.1	3.3	-0.2	-2.0	2.6
Bone: cortical thickness	1.7	2.0	4.1	2.0	1.7	-1.0	-0.4	1.3
Bone: cortical tissue density	1.0	1.3	2.6	1.6	1.3	-0.8	-0.3	1.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.2	0.0	-1.1	-0.8	1.1	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	0.2	-0.3	0.1	0.2
Condit. Reinf. active responses	1.2	1.4	2.2	0.3	-1.3	-1.3	1.5	-1.2
Condit. Reinf. inactive responses	1.9	2.3	4.0	1.2	-1.1	-2.0	1.8	-1.3
Incentive salience index mean	1.7	2.1	3.9	-1.0	-2.0	-0.3	1.4	-1.8
Condit. Reinf. lever presses	2.9	3.8	6.9	-1.6	-2.6	-0.2	1.9	-2.5
Condit. Reinf. active minus inactive responses	1.1	1.4	2.3	-0.6	0.9	1.5	-1.4	1.2
Condit. Reinf. active-inactive response ratio	2.5	2.6	4.6	-1.2	1.0	2.2	-2.0	1.4
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.0	0.0
Condit. Reinf. inactive responses	1.3	1.6	2.6	0.6	-1.1	-1.6	1.6	-1.1
Condit. Reinf. lever presses	0.2	0.3	0.6	0.2	-0.6	-0.2	0.8	-0.6
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	-0.2	-0.4	0.3	0.1	-0.2
Conditioned reinforcement - actives	0.7	0.7	1.4	0.0	1.0	1.2	-0.8	0.6
Conditioned reinforcement - inactives	1.1	1.2	2.2	0.7	1.5	0.4	-1.2	1.3
Conditioned locomotion	0.1	0.1	0.4	-0.4	0.0	0.6	-0.0	0.0
Patch foraging indifference point 0 sec	1.0	1.7	3.2	1.8	1.5	-1.2	-0.5	1.1
Patch foraging indifference point AUC	1.6	1.9	3.3	-0.5	1.2	1.3	-1.8	1.6
Delay disc. indifference point, 0s delay	0.6	0.6	2.2	-0.7	-0.3	1.5	-0.5	0.3
Delay disc. indifference point, 16s delay	1.4	1.5	3.0	1.7	1.5	-0.0	-0.3	1.4
Delay disc. indifference point, 2s delay	2.3	2.6	5.1	-0.9	1.0	2.3	-1.9	1.4
Delay disc. indifference point, 24s delay	0.4	0.4	0.7	0.5	0.8	0.4	-0.5	0.8
Delay disc. indifference point, 4s delay	1.7	1.8	3.7	-1.0	0.8	1.9	-1.3	1.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.2	0.4	0.4	-0.2	0.5
Indifference point function ln k	0.4	0.6	1.1	-0.8	-1.1	0.3	0.6	-1.0
Indifference point function log k	0.4	0.6	1.1	-0.8	-1.1	0.3	0.6	-1.0
Patch foraging total patch changes 0 sec	1.3	2.1	4.0	2.0	1.7	-1.3	-0.6	1.3
Patch foraging total patch changes 12 sec	1.4	1.8	3.3	1.7	1.8	-0.5	-0.8	1.4
Patch foraging total patch changes 18 sec	2.4	3.1	7.7	2.8	1.6	-2.1	-0.1	1.0
Patch foraging total patch changes 24 sec	2.5	3.0	8.3	2.9	1.1	-2.2	0.8	0.1
Patch foraging total patch changes 6 sec	1.8	2.6	5.5	2.3	1.8	-1.4	-0.8	1.4
Patch foraging time to switch 0 sec	0.6	1.0	2.3	1.5	0.5	-1.4	0.6	-0.1
Patch foraging water rate 0 sec	0.3	0.5	0.8	0.1	0.7	0.7	-0.7	0.9
Patch foraging water rate 12 sec	0.3	0.5	1.2	1.1	0.3	-0.9	0.5	0.0
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.3	0.1	0.2	-0.0	0.2
Patch foraging water rate 24 sec	1.0	1.4	2.7	0.0	1.4	0.9	-1.2	1.6
Patch foraging water rate 6 sec	0.2	0.3	0.8	0.9	0.4	-0.6	0.0	0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.3	0.4	0.4	-0.7	0.6
Distance traveled before self-admin	0.3	0.3	0.9	-1.0	-0.7	0.4	-0.0	-0.4
Distance traveled after self-admin	0.3	0.3	0.9	-1.0	-0.4	0.3	-0.6	0.3
Extensor digitorum longus weight	0.2	0.8	2.1	-1.5	-0.4	1.2	-0.4	-0.1
Bone: elastic displacement	0.6	0.6	1.1	1.0	0.8	-0.9	-0.4	0.7
Bone: elastic work	1.4	1.8	3.1	0.4	1.8	0.4	-1.7	1.6
Bone: endosteal estimation	3.6	7.8	16.9	-4.1	-0.2	3.9	-2.4	1.1
Bone: endosteal perimeter	2.5	5.1	14.0	-3.7	-1.7	2.8	-0.5	-0.7
Epididymis fat weight	5.5	12.7	27.3	5.2	4.3	-2.4	-1.0	3.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	-0.2	0.3	0.8	-0.1	0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.7	0.3	0.1	-0.9	-0.0	0.2
Diff in mean of infusions in LGA sessions	1.9	2.1	3.2	1.0	-1.3	-1.5	1.6	-1.8
Delay discount exponential model param	1.2	1.3	2.1	-0.3	-1.3	-1.2	1.1	-1.4
Extinction: sum of active levers before priming	0.6	0.6	1.0	0.5	-0.9	0.4	1.0	-0.8
Active lever presses in extinction session 6	0.3	0.3	0.9	0.9	0.3	-0.5	0.2	0.3
Bone: final force	4.4	7.1	12.3	0.6	3.5	1.3	-3.2	3.3
Bone: final moment	3.9	6.3	10.8	0.5	3.3	1.2	-3.1	3.1
Food consumed during 24 hour testing period	0.6	0.7	1.8	-1.3	0.0	0.7	-1.1	0.5
Glucose	4.2	6.3	13.7	-3.7	-2.7	2.4	0.6	-2.0
Heart weight	0.3	0.5	1.8	-0.4	0.3	1.3	-0.4	0.3
Delay discount hyperbolic model param	1.3	1.4	2.1	-0.0	-1.2	-1.4	1.2	-1.4
Intermittent access intake day 1-15 change	0.3	0.3	0.6	0.1	0.5	-0.5	-0.5	0.8
Intermittent access intake escalation	0.1	0.1	0.3	-0.6	0.0	-0.2	-0.3	0.3
Intermittent access intake escalation 2	1.2	1.2	3.9	-2.0	-1.1	0.4	0.1	-0.6
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.9	-1.1	-0.3	1.4	-0.5	0.1
Intermitt. access day 15 inactive lever presses	2.1	2.4	4.8	-0.2	1.6	1.0	-2.2	1.8
Intermitt. access escalation Index	2.0	1.7	3.0	0.2	-1.4	-0.9	1.7	-1.7
Intermittent access day 1 total infusions	0.3	0.3	0.6	0.5	-0.2	-0.6	0.8	-0.7
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.4	0.0	-0.7	0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	0.3	0.4	-0.0	-0.2	0.2
Intermittent access total infusions	0.1	0.1	0.2	0.5	0.3	-0.3	-0.0	0.0
Intermittent access day 1 locomotion	0.4	0.4	0.6	-0.5	-0.7	-0.3	0.7	-0.8
Intermittent access day 15 total locomotion	0.4	0.4	1.2	-1.1	-0.1	0.3	-0.7	0.5
Intermittent access total locomotion	0.2	0.2	0.9	-1.0	-0.0	0.0	-0.4	0.3
Intermittent access standard deviation	1.5	1.6	3.0	0.6	1.6	0.5	-1.3	1.7
Left kidney weight	2.9	8.2	13.4	-0.7	3.3	2.1	-3.7	3.4
Right kidney weight	2.1	5.9	9.2	-1.7	2.3	2.1	-3.0	2.8
Cocaine induced anxiety	1.9	2.2	4.1	-1.2	-2.0	-0.8	1.1	-1.9
Post-drug Anxiety	0.6	0.6	1.4	-0.9	-1.2	0.1	0.2	-1.0
Baseline Anxiety	0.4	0.4	0.8	0.9	0.5	0.8	-0.3	0.5
Tail length	3.6	10.9	16.1	-4.0	1.4	3.9	-3.8	2.6
Length with tail	3.2	11.6	17.8	-3.3	2.3	3.6	-4.2	3.3
Length without tail	2.4	5.3	8.0	-1.6	2.1	2.4	-2.8	2.4
Times rat made contact with spout	2.3	2.7	6.9	2.0	-0.2	-2.6	1.4	-0.6
Lifetime Intake	0.0	0.0	0.1	0.3	0.3	0.1	-0.1	0.0
Liver weight, left	0.6	1.0	3.0	-1.7	-0.3	0.8	-1.0	0.3
Liver weight, right	3.3	5.5	10.2	-3.2	0.6	2.8	-2.6	1.5
Locomotor activity	1.7	2.7	7.2	-2.7	-0.2	1.7	-1.7	0.5
Locomotor testing distance	0.3	0.5	1.5	-1.2	-0.2	0.8	-0.8	0.1
Locomotor testing rearing	0.6	1.0	2.2	-1.5	0.1	1.0	-1.2	0.5
Locomotion in novel chamber	0.4	0.5	1.2	-0.2	0.7	0.1	-1.1	1.0
Locomotion in novel chamber post-restriction	0.4	0.4	0.8	0.4	0.8	0.2	-0.7	0.9
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	0.1	-0.6	-0.6	0.6	-0.8
Change in fecal boli incidents, locomotor task	1.3	1.3	3.6	-0.6	0.6	1.9	-1.2	0.8
Time >=10cm from walls, locomotor time 1	1.3	1.4	2.3	-1.5	0.4	1.5	-1.4	0.5
Bouts of movement, locomotor time 1	1.5	1.7	2.9	-0.7	-1.7	-0.8	1.6	-1.4
Total resting periods, locomotor time 1	1.1	1.2	2.2	-0.9	-1.5	-0.4	1.3	-1.1
Rest time, locomotor task time 1	0.5	0.5	2.1	-1.5	-0.6	0.0	-0.2	-0.3
Distance moved, locomotor task time 1	0.6	0.6	1.0	0.7	1.0	0.4	-0.6	1.0
Vertical activity count, locomotor time 1	0.5	0.5	1.1	0.7	1.1	0.3	-0.5	0.8
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.7	-1.0	0.3	1.3	-0.8	0.1
Bouts of movement, locomotor time 2	0.8	0.9	3.0	-1.7	0.1	0.7	-0.8	0.3
Total resting periods, locomotor time 2	1.0	1.1	4.3	-2.1	-0.3	0.8	-0.6	-0.1
Rest time, locomotor task time 2	1.8	2.1	6.5	-2.6	-1.6	0.6	0.0	-1.0
Distance moved, locomotor task time 2	1.1	1.2	2.5	1.6	1.4	0.1	-0.6	1.2
Vertical activity count, locomotor time 2	0.3	0.4	1.2	1.1	0.7	0.1	-0.1	0.5
Light reinforcement 1	0.3	0.6	1.2	1.1	1.1	-0.6	-0.1	0.7
Light reinforcement 2	0.3	0.4	0.6	-0.7	0.5	0.0	-0.8	0.7
Bone: marrow area	3.6	7.7	16.5	-4.1	-0.1	3.9	-2.4	1.1
Bone: maximum diameter	1.4	2.6	6.6	-2.6	-0.5	2.3	-1.0	-0.1
Bone: maximum force	3.4	5.9	9.6	0.2	3.1	1.2	-3.0	3.0
Bone: maximum moment	3.1	5.3	8.4	0.1	2.9	1.2	-2.9	2.9
Mean time between licks in bursts	1.9	2.7	7.0	-2.6	-1.7	1.6	0.0	-1.1
Mean num. licks in bursts	1.9	2.2	5.8	2.1	0.9	-2.4	0.3	0.6
Cd content in liver	0.7	0.8	1.2	1.1	1.0	-0.8	-0.6	0.9
Co content in liver	1.6	1.8	3.4	1.3	1.8	0.1	-1.1	1.7
Cu content in liver	3.1	3.8	6.7	2.3	-0.7	-2.6	2.2	-1.3
Fe content in liver	0.9	1.0	1.9	1.0	1.4	-0.7	-0.7	1.1
K content in liver	0.3	0.3	0.4	-0.0	-0.6	0.6	0.5	-0.6
Mg content in liver	2.9	3.0	5.8	-1.5	-2.4	0.9	1.5	-2.0
Mn content in liver	4.1	4.7	8.9	-3.0	-2.6	2.1	0.7	-1.7
Na content in liver	0.1	0.1	0.2	0.4	0.4	0.3	-0.2	-0.0
Rb content in liver	0.7	0.9	1.5	0.3	-1.1	-0.7	1.2	-1.1
Se content in liver	2.7	3.3	6.6	-2.6	-2.1	1.5	0.7	-1.7
Sr content in liver	0.9	0.8	1.8	-1.2	0.2	1.4	-0.8	0.4
Zn content in liver	0.2	0.2	0.6	-0.5	-0.1	0.8	-0.0	-0.1
Bone: minimum diameter	1.9	3.5	8.6	-2.9	-0.6	2.7	-1.1	0.1
Time in familiar zone, hab. session 1	3.4	3.1	5.7	2.1	-0.6	-2.4	2.0	-1.1
Time in novel zone, hab. session 1	2.0	1.9	3.5	-1.9	0.2	1.9	-1.4	0.8
Total zone transitions, hab. session 1	0.5	0.7	1.4	0.4	-0.7	-0.7	1.2	-0.9
Total locomotion distance, hab. session 1	0.4	0.6	1.1	0.5	-0.6	-0.6	1.1	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.6	0.7	-0.1	-0.4	0.7	-0.5
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.8	-0.2	-0.7	0.7	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.2	0.5	-0.1	-0.7	0.7
Total zone transitions, hab. session 2	0.1	0.1	0.4	0.6	0.4	-0.3	0.2	0.0
Total locomotion distance, hab. session 2	0.8	1.1	2.0	0.8	-0.7	-1.1	1.4	-1.1
Locomotion velocity, hab. session 2	0.8	1.1	2.1	0.7	-0.8	-0.9	1.5	-1.2
Novel to familiar place preference ratio	0.1	0.2	0.3	0.6	0.5	-0.4	0.0	0.1
Novelty place preference	0.1	0.1	0.3	0.4	0.6	-0.2	-0.2	0.3
Time in novel zone, NPP test	0.1	0.1	0.4	0.2	0.6	-0.1	-0.4	0.4
Total zone transitions, NPP test	1.0	1.4	2.2	0.4	-1.1	-1.3	1.5	-1.3
Total locomotion distance, NPP test	1.1	1.5	2.4	1.0	-0.7	-1.6	1.4	-1.1
Locomotion velocity, NPP test	1.6	2.3	3.6	1.2	-1.0	-1.8	1.9	-1.5
Intraocular pressure	1.2	1.6	3.8	0.5	-1.0	-1.9	1.3	-1.1
Delta distance traveled before/after self-admin	0.7	0.7	1.5	-0.1	0.9	0.1	-1.1	1.2
Delta ambulatory time before/after self-admin	0.4	0.4	0.9	-0.6	0.4	0.3	-0.9	0.7
Parametrial fat weight	1.6	3.1	5.5	0.3	2.3	0.5	-2.1	2.4
Pavlov. Cond. lever latency	2.3	3.0	5.3	2.3	2.1	-1.2	-0.7	1.8
Pavlov. Cond. magazine entry latency	2.1	2.7	4.6	-2.2	-2.1	0.6	0.9	-1.8
Pavlov. Cond. change in total contacts	1.3	1.4	3.8	-1.9	-0.4	1.6	-0.7	-0.1
Pavlov. Cond. index score	2.9	3.7	6.6	-2.6	-2.3	1.1	0.9	-2.1
Pavlov. Cond. latency score	2.6	3.3	6.8	-2.6	-2.1	1.4	0.5	-1.8
Pavlov. Cond. lever contacts	2.2	2.5	5.6	-2.4	-1.6	1.6	0.1	-1.4
Pavlov. Cond. magazine entry number	2.0	2.5	4.8	1.6	2.2	-0.2	-1.3	1.8
Pavlov. Cond. intertrial magazine entries	1.5	1.8	4.2	2.1	0.2	-2.0	0.9	0.1
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	6.1	-2.5	-2.4	1.0	1.0	-2.1
Pavlov. Cond. response bias	2.7	3.3	5.7	-2.3	-2.4	0.7	1.1	-2.0
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.5	0.2	0.7	-0.6	0.4
Pavlov. Cond. magazine entry latency	0.5	0.5	0.9	-0.7	0.5	0.9	-0.9	0.5
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.6	0.8	-0.2	-0.6	0.7
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.1	0.4	0.1	-0.3	0.3
Pavlov. Cond. lever contacts	0.4	0.6	1.5	1.1	0.3	-1.2	0.3	0.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.1	-0.6	-0.1	0.7	-0.5
Pavlov. Cond. intertrial magazine entries	1.6	2.1	4.1	-1.5	-2.0	0.3	1.2	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Pavlov. Cond. response bias	0.2	0.2	0.7	0.4	0.0	-0.9	0.2	-0.2
Time in closed arm before self-admin	0.1	0.1	0.2	0.1	0.2	0.2	-0.4	0.1
Time in closed arm after self-admin	1.0	1.0	2.0	0.7	1.4	0.5	-1.0	1.1
Time in open arm before self-admin	0.6	0.6	1.0	-0.9	-1.0	-0.4	0.7	-0.9
Time in open arm after self-admin	1.0	1.1	1.9	-0.5	-1.4	-1.0	1.0	-1.2
Bone: periosteal estimation	2.6	5.4	9.7	-2.6	0.9	3.1	-2.6	1.7
Bone: periosteal perimeter	1.7	2.8	5.9	-2.3	0.1	2.4	-1.5	0.6
Bone: post-yield work	0.8	1.0	3.2	-1.8	-1.2	0.5	0.1	-0.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.2	-0.1	0.2	0.6	-0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.3	0.0	0.3	0.5	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.3	1.2	1.1	0.3	-0.4	0.2	0.1
Progressive ratio test 2 active lever presses	0.4	0.5	0.6	0.7	-0.2	-0.7	0.8	-0.8
Progressive ratio test 2 breakpoint	0.9	1.0	1.6	0.9	-0.3	-1.2	1.3	-1.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.9	-0.3	0.8	0.3	-0.9	0.5
Incentive Sensitization - Responses	0.5	0.5	0.8	0.5	-0.2	-0.8	0.9	-0.8
Incentive Sensitization - Breakpoint	0.6	0.6	1.1	0.4	-0.3	-0.9	1.1	-0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.3	-0.7	-0.2	0.4	-0.6
Progressive ratio	3.3	3.8	6.6	0.1	2.3	0.9	-2.5	2.6
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.0	0.2	-0.2	0.1	-0.1
Seeking ratio, punishment vs. effort	2.7	3.3	5.9	-0.1	-2.0	-0.8	2.4	-2.4
Retroperitoneal fat weight	0.3	0.8	1.7	0.1	1.3	0.3	-1.0	1.2
Reaction time number correct	0.6	0.9	2.6	1.6	1.1	-0.6	-0.1	0.7
Reaction time mean minus median	2.2	3.0	9.1	-3.0	-2.0	0.4	0.1	-1.2
Reaction time mean minus median AUC	1.7	2.2	6.0	-2.4	-1.8	0.4	0.4	-1.2
Reaction time num false alarms	0.4	0.5	1.3	-0.6	0.3	1.1	-0.6	0.6
Reaction time num false alarms AUC	0.7	0.9	2.5	-0.7	0.5	1.6	-0.8	0.8
Reaction time trials correct on left	0.6	0.9	2.6	1.6	1.1	-0.6	-0.1	0.7
Reaction time trials on left	0.6	0.8	2.2	1.5	1.0	-0.5	-0.2	0.7
Reaction time mean	2.4	3.3	7.5	-2.7	-2.4	0.5	0.7	-1.6
Reaction time mean AUC	2.5	3.3	7.6	-2.8	-2.4	0.4	0.7	-1.6
Median of all reaction times	1.6	2.2	4.4	-2.1	-2.0	0.4	0.7	-1.4
Reaction time omissions	1.7	2.4	5.9	-2.4	-1.8	0.9	0.4	-1.3
Reaction time false alarm rate	0.9	1.3	3.5	-1.5	-0.3	1.9	-0.5	0.2
Reaction time premature initiation rate	1.2	1.6	2.5	0.0	1.5	1.1	-1.6	1.4
Reaction time premature initiations	1.7	2.4	4.5	0.8	2.1	0.9	-1.7	1.9
Std. dev. reaction times	2.4	3.3	10.3	-3.2	-2.1	0.9	0.0	-1.2
Reaction time trials completed	0.6	0.8	2.2	1.5	1.0	-0.5	-0.2	0.7
Reaction time trials AUC	0.6	0.8	2.3	1.5	1.0	-0.6	-0.2	0.7
Run reversals in cocaine runway, females	0.7	0.7	1.8	1.3	0.8	-0.8	0.3	0.4
Run reversals in cocaine runway, males	1.5	1.4	4.7	-2.2	-0.1	0.9	-1.3	0.2
Latency to leave start box in cocaine runway	0.5	0.6	1.4	-0.1	0.4	1.2	-1.0	0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	-0.3	-0.4	0.7	-0.3	-0.3
Latency to leave start box in cocaine runway, M	1.2	1.2	2.2	0.5	1.3	0.6	-1.2	1.5
Std. dev. time between licks in bursts	2.5	3.0	7.1	-2.7	-1.3	2.4	-0.3	-0.7
Total sessions with >9 infusions	0.1	0.1	0.5	-0.0	0.4	0.7	-0.1	0.2
Short access day 1 total inactive lever presses	1.1	1.3	3.4	-1.8	-0.6	1.5	-0.5	-0.3
Short access day 10 total inactive lever presses	0.3	0.3	0.7	-0.8	-0.8	0.4	-0.2	-0.2
Short access day 1 total infusions	0.2	0.2	0.5	-0.2	-0.1	0.7	0.6	-0.6
Short access day 10 total infusions	0.1	0.1	0.3	0.1	0.5	0.6	-0.1	0.2
Short access total infusions	0.3	0.3	1.0	-0.0	0.6	1.0	-0.2	0.2
Short access day 1 locomotion	2.3	2.5	4.7	0.0	-1.7	-0.6	2.2	-2.1
Short access day 10 total locomotion	1.4	1.6	4.1	-1.7	-0.7	2.0	0.6	-0.5
Short access total locomotion	0.5	0.6	0.9	-0.7	-0.6	1.0	0.8	-0.7
One hour access (0.3 mA shock)	0.4	0.5	0.9	0.1	-0.5	-0.6	0.9	-1.0
Compulsive drug intake	1.9	1.9	3.8	-0.2	-1.7	-0.0	1.7	-2.0
One hour access (shock baseline)	0.4	0.4	0.8	-0.4	0.8	-0.2	-0.9	0.7
Social response proportion	0.5	0.6	1.6	-1.0	-0.2	1.3	-0.1	-0.1
Social responses	0.4	0.5	2.0	-0.4	0.5	1.4	-0.2	0.4
Social time	2.3	3.0	7.8	-2.8	-1.1	2.3	-0.3	-0.6
Soleus weight	2.1	6.2	16.4	-4.1	-1.5	3.4	-0.9	-0.4
Bone: stiffness	0.9	1.4	2.8	0.7	1.7	0.1	-1.2	1.5
Tibialis anterior weight	0.3	1.0	2.6	1.6	1.0	-1.1	0.1	0.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.6	-0.3	-0.2	-0.5	-0.2
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.2	-1.2	-1.5	-0.2	0.6	-1.2
Time to tail flick, test, before self-admin	0.3	0.3	0.4	0.6	0.6	-0.4	-0.6	0.5
Time to tail flick, test, after self-admin	1.8	1.8	3.0	-0.7	-1.7	-1.5	1.2	-1.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.2	-0.0	-0.9	-0.8	1.1	-1.0
Delta time to tail flick, test, before/after SA	1.7	1.5	2.3	0.0	-1.4	-1.3	1.5	-1.2
Tibia length	2.4	6.7	11.9	-3.1	1.0	3.5	-2.8	1.9
Ambulatory time before self-admin	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.1	-0.1
Ambulatory time after self-admin	0.3	0.3	0.8	-0.9	-0.4	-0.1	-0.6	0.3
Bone: tissue strength	3.2	3.1	5.2	0.3	2.3	0.8	-2.3	2.1
Total heroin consumption	0.0	0.1	0.1	-0.0	-0.2	-0.4	0.3	-0.2
Bone: trabecular number	1.9	3.0	7.0	1.8	-0.7	-2.6	1.8	-1.2
Bone: trabecular spacing	3.6	4.6	7.5	-1.5	1.6	2.7	-2.6	2.0
Bone: trabecular thickness	1.3	1.6	3.5	1.1	-0.6	-1.9	1.3	-1.0
Bone: trabecular tissue density	1.5	2.1	3.0	-0.1	1.7	1.4	-1.7	1.6
Water consumed over 24 hours	0.1	0.1	0.4	-0.5	-0.3	0.6	-0.1	-0.2
Number of responses in last shaping day	0.9	0.9	2.8	-0.7	0.4	1.7	-1.0	0.5