Hub : Genes

Ttll12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Ttll12 0.1 0.08 4.3e-05 0.05 0.08 0.06 0.05 3.2e-03 2.6e-04 1.8e-03 2.6e-03
2 Brain gene expression Ttll12 0.18 0.09 0.0e+00 0.26 0.26 0.26 0.26 2.1e-24 4.9e-24 2.1e-24 1.8e-24
3 NAcc gene expression Ttll12 0.02 0.02 2.9e-03 0.01 0 0.01 0 2.9e-02 8.5e-02 8.7e-03 1.2e-01
4 IL gene expression Ttll12 0.55 0.18 7.7e-11 0.24 0.25 0.27 0.27 2.1e-06 8.2e-07 4.2e-07 4.3e-07
5 BLA gene expression Ttll12 0.36 0.14 0.0e+00 0.3 0.32 0.31 0.32 1.9e-16 1.4e-17 3.2e-17 2.0e-17
6 PL gene expression Ttll12 0.4 0.11 0.0e+00 0.56 0.56 0.56 0.52 7.7e-75 3.2e-73 3.5e-74 4.2e-67
7 OFC gene expression Ttll12 0.71 0.14 0.0e+00 0.4 0.35 0.35 0.38 1.8e-10 3.2e-09 2.9e-09 5.3e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.30.50.8-0.7-0.70.70.6-0.60.60.9
Area under the delay curve1.92.02.3-1.5-1.21.41.5-1.31.41.5
BMI with tail1.75.66.52.42.4-2.4-2.32.3-2.5-2.4
BMI without tail0.61.21.51.11.0-1.0-1.21.0-1.2-1.1
Body weight1.56.57.92.42.8-2.6-2.32.7-2.8-2.0
Weight adjusted by age0.10.10.20.30.4-0.3-0.40.2-0.4-0.3
Bone surface0.00.00.1-0.0-0.00.1-0.20.4-0.00.2
Bone volume0.00.00.1-0.1-0.10.1-0.10.20.00.3
Breakpoint value in progressive ratio session0.10.10.20.20.3-0.3-0.10.4-0.3-0.1
Number of licking bursts0.10.20.2-0.4-0.40.40.4-0.40.50.3
Context. condit. distance diff. score5.87.07.72.82.6-2.7-2.62.5-2.7-2.7
Locomotion velocity, session 10.91.01.61.00.8-0.8-1.31.2-0.8-1.0
Locomotion distance, session 10.50.61.2-0.5-1.11.10.3-0.90.80.3
Locomotion velocity, session 21.11.22.11.10.8-1.0-1.51.1-1.0-1.2
Locomotion distance, session 21.31.82.6-1.2-1.61.60.9-1.51.41.1
Locomotion velocity, session 30.70.81.50.90.4-0.5-1.20.8-0.8-1.1
Locomotion distance, session 31.01.01.6-0.9-1.31.20.9-1.30.80.6
Stereotopy head waving bouts, day 31.11.32.41.00.9-1.0-1.51.3-1.0-1.0
Stereotopy head waving duration, day 35.56.69.32.52.4-2.4-3.12.7-2.5-2.4
Locomotion velocity, session 70.10.10.20.1-0.30.1-0.4-0.0-0.5-0.3
Locomotion distance, session 71.01.22.1-1.1-1.41.41.0-1.20.70.9
Stereotopy head waving bouts, day 75.66.38.62.52.5-2.4-2.92.7-2.3-2.2
Stereotopy head waving duration, day 73.54.35.62.12.1-2.0-2.42.2-1.9-1.8
Locomotion velocity, session 86.88.19.33.02.9-2.8-3.02.7-2.6-2.9
Locomotion distance, session 81.01.52.01.41.2-1.1-1.41.1-1.1-1.3
Degree of sensitization distance0.90.91.10.91.0-1.0-0.91.1-1.0-0.8
Degree of sensitization stereotypy3.84.25.12.12.1-2.0-2.32.0-2.0-1.9
Conditioned locomotion0.00.10.20.20.4-0.3-0.10.3-0.1-0.1
Cocaine response after cond. corrected0.00.00.00.10.0-0.00.0-0.00.20.0
Cocaine response after cond. not corrected0.00.00.00.20.1-0.1-0.1-0.00.2-0.2
Cocaine response before conditioning0.10.10.1-0.3-0.30.30.2-0.30.40.1
Saline control response0.20.20.40.40.5-0.5-0.60.6-0.3-0.4
Bone: connectivity density0.10.10.3-0.4-0.40.40.2-0.20.20.5
Bone: cortical apparent density1.31.72.1-1.4-1.11.31.4-1.21.31.5
Bone: cortical area1.52.32.71.61.7-1.6-1.41.6-1.5-1.3
Bone: cortical porosity0.60.70.90.70.7-0.8-0.90.8-0.9-0.9
Bone: cortical porosity1.31.51.71.11.2-1.3-1.21.3-1.2-1.2
Bone: cortical thickness0.00.10.30.00.5-0.30.10.2-0.30.1
Bone: cortical thickness0.30.30.60.50.7-0.7-0.30.3-0.6-0.5
Bone: cortical tissue density1.21.61.9-1.3-1.11.21.3-1.11.31.4
Condit. Reinf. active minus inactive responses1.41.52.3-1.3-1.11.11.2-1.01.41.5
Condit. Reinf. active-inactive response ratio0.00.00.20.00.2-0.2-0.20.4-0.00.1
Condit. Reinf. active responses3.74.55.2-2.1-2.02.02.2-2.02.32.2
Condit. Reinf. inactive responses4.04.85.4-2.1-2.22.22.2-2.32.22.0
Incentive salience index mean2.32.83.7-1.8-1.51.51.7-1.41.81.9
Condit. Reinf. lever presses2.33.13.8-1.9-1.61.71.7-1.51.91.9
Condit. Reinf. active minus inactive responses0.10.10.20.10.3-0.3-0.40.5-0.1-0.1
Condit. Reinf. active-inactive response ratio0.10.10.40.20.4-0.3-0.40.6-0.1-0.0
Condit. Reinf. active responses0.91.21.70.91.1-1.1-1.31.3-0.8-1.0
Condit. Reinf. inactive responses1.01.21.71.01.0-1.1-1.31.2-1.0-1.2
Condit. Reinf. lever presses0.10.10.5-0.4-0.40.20.0-0.20.70.2
Condit. Reinf. lever reinforcers received0.20.30.70.40.6-0.6-0.80.9-0.2-0.4
Conditioned reinforcement - actives0.20.20.4-0.5-0.20.20.5-0.30.50.6
Conditioned reinforcement - inactives0.10.10.1-0.1-0.30.30.2-0.30.00.2
Conditioned locomotion0.60.81.00.91.0-0.9-1.00.9-0.7-0.6
Patch foraging indifference point 0 sec0.10.10.2-0.4-0.50.30.4-0.30.30.4
Patch foraging indifference point AUC0.10.10.2-0.5-0.30.30.5-0.20.40.2
Delay disc. indifference point, 0s delay0.30.30.70.50.4-0.5-0.50.6-0.8-0.5
Delay disc. indifference point, 16s delay3.53.64.3-2.0-1.61.82.0-1.82.02.1
Delay disc. indifference point, 2s delay0.40.50.7-0.7-0.80.80.7-0.70.50.6
Delay disc. indifference point, 24s delay0.50.50.7-0.8-0.60.70.8-0.60.70.8
Delay disc. indifference point, 4s delay0.10.10.2-0.3-0.40.40.3-0.30.30.3
Delay disc. indifference point, 8s delay3.13.23.6-1.8-1.61.71.9-1.71.81.8
Indifference point function ln k1.31.83.01.31.3-1.1-1.41.4-1.7-1.0
Indifference point function log k1.31.83.01.31.3-1.1-1.41.4-1.7-1.0
Patch foraging total patch changes 0 sec0.10.20.4-0.4-0.60.40.5-0.40.30.4
Patch foraging total patch changes 12 sec0.10.10.30.20.0-0.3-0.30.40.1-0.5
Patch foraging total patch changes 18 sec0.00.00.1-0.30.10.00.20.10.10.3
Patch foraging total patch changes 24 sec0.10.20.4-0.4-0.60.40.4-0.40.40.2
Patch foraging total patch changes 6 sec0.00.00.00.00.1-0.10.10.1-0.1-0.1
Patch foraging time to switch 0 sec0.30.41.1-0.7-0.60.60.4-0.51.00.7
Patch foraging water rate 0 sec0.60.91.51.10.8-0.9-0.80.5-1.2-1.2
Patch foraging water rate 12 sec0.40.71.20.90.4-0.2-1.10.4-1.1-1.1
Patch foraging water rate 18 sec0.00.00.2-0.0-0.30.40.0-0.20.10.1
Patch foraging water rate 24 sec2.02.83.41.51.8-1.4-1.81.8-1.7-1.5
Patch foraging water rate 6 sec0.10.20.4-0.4-0.50.60.3-0.40.20.4
Seeking ratio, delayed vs. immediate footshock2.63.04.9-1.7-2.22.21.4-1.91.21.1
Distance traveled before self-admin0.10.10.2-0.2-0.40.3-0.1-0.30.3-0.3
Distance traveled after self-admin0.40.40.90.50.5-0.5-0.80.5-0.5-1.0
Extensor digitorum longus weight0.00.00.10.20.1-0.10.1-0.1-0.3-0.2
Bone: elastic displacement1.31.51.91.31.2-1.2-1.41.1-1.3-1.2
Bone: elastic work4.66.06.62.52.5-2.5-2.62.4-2.3-2.3
Bone: endosteal estimation2.24.96.72.51.7-1.9-2.62.2-2.0-2.4
Bone: endosteal perimeter2.04.25.32.21.8-1.9-2.32.2-1.9-2.0
Epididymis fat weight1.33.14.11.52.0-1.9-1.72.0-1.7-1.5
Delta time in closed arm before/after self-admin0.10.10.20.10.3-0.50.10.10.10.0
Delta time in open arm before/after self-admin0.20.20.70.5-0.0-0.1-0.60.0-0.2-0.8
Diff in mean of infusions in LGA sessions1.01.11.6-1.1-0.90.81.3-1.11.11.1
Delay discount exponential model param1.81.92.21.41.2-1.4-1.51.3-1.3-1.4
Extinction: sum of active levers before priming0.20.20.4-0.3-0.50.30.5-0.50.60.6
Active lever presses in extinction session 60.50.50.60.80.7-0.6-0.60.7-0.6-0.7
Bone: final force0.91.52.11.31.4-1.4-1.11.3-1.0-1.0
Bone: final moment1.52.53.11.71.7-1.8-1.51.6-1.3-1.4
Food consumed during 24 hour testing period2.53.03.41.81.7-1.7-1.81.7-1.6-1.8
Glucose0.60.91.1-1.1-1.11.10.9-0.90.80.9
Heart weight2.63.65.51.82.4-2.3-1.51.9-1.8-1.5
Delay discount hyperbolic model param1.31.41.61.21.0-1.2-1.31.1-1.1-1.2
Intermittent access intake day 1-15 change0.70.71.2-0.9-0.60.70.7-0.81.10.8
Intermittent access intake escalation0.50.50.9-0.8-0.50.60.6-0.70.90.7
Intermittent access intake escalation 20.10.10.2-0.4-0.30.30.3-0.40.40.3
Intermitt. access day 1 inactive lever presses0.80.81.21.10.8-0.9-0.80.8-0.9-1.1
Intermitt. access day 15 inactive lever presses0.60.70.91.00.8-0.9-0.80.8-0.5-0.8
Intermitt. access escalation Index0.10.10.1-0.3-0.30.30.2-0.30.30.3
Intermittent access day 1 total infusions0.60.71.20.90.9-0.8-0.70.9-1.1-0.6
Intermittent access day 15 total infusions0.00.00.10.20.1-0.1-0.30.1-0.2-0.1
Intermittent access terminal intake (last 3 days)0.00.00.00.1-0.0-0.0-0.1-0.2-0.1-0.1
Intermittent access total infusions0.10.20.30.50.2-0.3-0.50.2-0.5-0.4
Intermittent access day 1 locomotion0.00.00.10.20.3-0.20.00.2-0.30.1
Intermittent access day 15 total locomotion0.10.10.20.40.4-0.1-0.50.2-0.2-0.3
Intermittent access total locomotion0.20.20.30.50.3-0.3-0.60.3-0.5-0.6
Intermittent access standard deviation0.40.40.60.70.8-0.7-0.60.5-0.5-0.6
Left kidney weight14.841.647.86.46.9-6.8-6.56.8-6.0-5.7
Right kidney weight16.145.350.16.87.1-6.9-6.86.9-6.3-6.2
Cocaine induced anxiety2.42.84.81.81.4-1.5-1.71.5-1.3-2.2
Post-drug Anxiety1.82.02.81.51.3-1.2-1.41.4-1.5-1.7
Baseline Anxiety1.92.03.8-1.6-1.11.41.6-1.20.92.0
Tail length0.00.10.3-0.3-0.10.20.3-0.00.10.5
Length with tail0.20.81.50.71.2-0.9-0.71.2-1.0-0.2
Length without tail0.40.91.60.81.1-1.0-0.81.3-1.0-0.4
Times rat made contact with spout1.71.92.31.41.3-1.3-1.41.2-1.5-1.5
Lifetime Intake0.40.50.80.80.6-0.6-0.90.6-0.7-0.8
Liver weight, left0.20.30.60.40.5-0.4-0.80.8-0.5-0.2
Liver weight, right0.30.51.20.50.9-0.8-0.71.1-0.6-0.2
Locomotor activity2.64.14.82.02.1-2.1-2.12.2-1.9-1.6
Locomotor testing distance0.00.00.10.0-0.20.1-0.1-0.10.30.3
Locomotor testing rearing0.40.71.00.80.9-1.0-0.90.9-0.5-0.6
Locomotion in novel chamber0.10.20.3-0.6-0.50.30.3-0.40.40.4
Locomotion in novel chamber post-restriction0.91.11.3-1.0-1.21.11.0-1.11.00.9
Fecal boli incidents, locomotor time 10.20.20.6-0.4-0.60.60.2-0.40.70.2
Change in fecal boli incidents, locomotor task0.60.60.80.70.9-0.8-0.50.9-0.8-0.6
Time >=10cm from walls, locomotor time 10.00.00.10.0-0.30.1-0.1-0.00.1-0.0
Bouts of movement, locomotor time 10.10.10.2-0.4-0.10.20.2-0.40.50.2
Total resting periods, locomotor time 10.30.30.5-0.6-0.40.50.4-0.70.70.4
Rest time, locomotor task time 10.00.10.1-0.2-0.30.3-0.2-0.30.1-0.1
Distance moved, locomotor task time 10.10.10.30.40.5-0.4-0.20.6-0.20.0
Vertical activity count, locomotor time 10.00.00.10.20.1-0.10.00.3-0.10.1
Time >=10cm from walls, locomotor time 20.30.40.4-0.6-0.60.60.5-0.60.60.6
Bouts of movement, locomotor time 20.20.20.4-0.5-0.10.10.6-0.20.40.5
Total resting periods, locomotor time 20.10.20.4-0.5-0.00.10.6-0.20.40.6
Rest time, locomotor task time 20.10.20.3-0.5-0.40.50.3-0.40.20.4
Distance moved, locomotor task time 20.60.70.80.90.8-0.8-0.80.7-0.7-0.9
Vertical activity count, locomotor time 20.60.70.90.90.8-0.9-0.80.9-0.7-0.8
Light reinforcement 10.40.61.20.80.8-0.7-1.01.1-0.6-0.5
Light reinforcement 20.50.71.40.70.6-0.5-1.21.1-0.9-0.7
Bone: marrow area2.55.47.32.61.8-2.0-2.72.3-2.1-2.5
Bone: maximum diameter5.610.311.43.43.1-3.1-3.33.3-3.2-3.1
Bone: maximum force2.74.75.42.32.3-2.3-2.12.2-2.0-2.0
Bone: maximum moment3.66.26.92.62.6-2.6-2.42.5-2.4-2.3
Mean time between licks in bursts0.81.11.6-1.1-0.80.81.2-1.31.20.9
Mean num. licks in bursts2.02.42.81.61.5-1.5-1.51.4-1.7-1.5
Cd content in liver1.82.03.31.51.8-1.8-1.01.0-1.4-1.3
Co content in liver0.70.81.30.91.1-1.1-0.80.5-0.9-0.8
Cu content in liver5.97.18.1-2.8-2.52.72.6-2.42.82.9
Fe content in liver0.40.50.70.60.7-0.5-0.80.9-0.7-0.6
K content in liver0.30.30.5-0.6-0.60.60.2-0.30.60.7
Mg content in liver0.80.81.2-1.0-1.11.10.5-0.60.91.1
Mn content in liver0.10.10.20.10.2-0.1-0.40.3-0.1-0.2
Na content in liver2.22.43.2-1.5-1.81.81.4-1.61.11.4
Rb content in liver0.00.10.2-0.00.2-0.2-0.40.4-0.00.0
Se content in liver1.21.41.9-1.3-1.11.21.1-0.91.21.4
Sr content in liver1.11.01.9-0.9-0.90.81.3-1.40.90.9
Zn content in liver0.80.91.2-1.0-0.80.90.9-0.91.01.1
Bone: minimum diameter0.71.21.71.21.1-1.0-1.21.3-0.8-1.0
Time in familiar zone, hab. session 10.10.10.30.50.2-0.2-0.50.3-0.4-0.4
Time in novel zone, hab. session 11.31.22.00.91.3-1.4-0.80.9-1.1-1.1
Total zone transitions, hab. session 12.12.93.7-1.7-1.81.91.6-1.71.71.6
Total locomotion distance, hab. session 10.40.61.0-0.8-0.91.00.5-0.60.70.7
Locomotion velocity, hab. session 10.71.01.8-1.0-1.21.30.7-0.80.90.9
Time in familiar zone, hab. session 20.10.10.2-0.3-0.20.30.5-0.30.30.4
Time in novel zone, hab. session 21.01.01.30.90.9-1.0-1.00.9-1.0-1.1
Total zone transitions, hab. session 20.10.10.2-0.2-0.40.5-0.1-0.20.40.0
Total locomotion distance, hab. session 20.10.20.4-0.3-0.50.60.2-0.30.50.3
Locomotion velocity, hab. session 20.40.61.0-0.7-0.91.00.5-0.70.80.6
Novel to familiar place preference ratio3.53.65.21.82.3-2.2-1.61.8-1.8-1.7
Novelty place preference4.54.66.52.02.5-2.5-1.92.0-2.1-1.9
Time in novel zone, NPP test6.06.28.32.42.9-2.8-2.22.3-2.5-2.3
Total zone transitions, NPP test0.71.01.3-0.8-1.11.10.8-1.11.10.7
Total locomotion distance, NPP test0.30.40.5-0.5-0.70.70.5-0.60.70.4
Locomotion velocity, NPP test1.31.82.2-1.2-1.51.51.2-1.41.51.2
Intraocular pressure0.40.50.90.80.7-0.6-0.60.6-0.8-0.9
Delta distance traveled before/after self-admin2.12.22.51.51.6-1.5-1.41.5-1.6-1.4
Delta ambulatory time before/after self-admin3.23.54.41.82.1-2.0-1.71.9-2.0-1.6
Parametrial fat weight0.10.20.3-0.6-0.30.20.5-0.40.20.6
Pavlov. Cond. lever latency2.83.64.82.01.7-1.8-1.81.6-2.1-2.2
Pavlov. Cond. magazine entry latency2.53.23.7-1.9-1.61.71.9-1.81.71.9
Pavlov. Cond. change in total contacts2.52.73.3-1.8-1.51.51.8-1.51.61.8
Pavlov. Cond. index score1.82.33.0-1.7-1.31.41.6-1.41.51.7
Pavlov. Cond. latency score1.51.92.6-1.5-1.11.21.4-1.21.41.6
Pavlov. Cond. lever contacts3.44.05.0-2.1-1.82.01.9-1.82.02.2
Pavlov. Cond. magazine entry number2.22.83.51.81.4-1.5-1.91.7-1.5-1.8
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.7-0.70.70.7-0.80.80.6
Pavlov. Cond. lever-magazine prob. diff.2.53.03.7-1.9-1.61.71.8-1.61.61.9
Pavlov. Cond. response bias3.64.45.3-2.3-1.92.02.2-2.02.02.3
Pavlov. Cond. lever latency0.20.20.40.60.6-0.5-0.20.1-0.6-0.5
Pavlov. Cond. magazine entry latency3.13.64.4-2.0-2.01.91.7-1.72.11.7
Pavlov. Cond. change in total contacts0.10.20.4-0.5-0.50.40.00.00.60.6
Pavlov. Cond. index score1.41.82.4-1.5-1.51.31.1-1.11.61.3
Pavlov. Cond. latency score1.72.22.8-1.6-1.71.51.2-1.21.71.4
Pavlov. Cond. lever contacts0.20.30.5-0.6-0.70.60.1-0.10.60.5
Pavlov. Cond. magazine entry number1.82.22.91.61.6-1.5-1.31.2-1.7-1.4
Pavlov. Cond. intertrial magazine entries2.53.34.31.92.1-2.0-1.61.5-1.9-1.7
Pavlov. Cond. lever-magazine prob. diff.1.62.12.8-1.6-1.61.51.1-1.21.71.4
Pavlov. Cond. response bias0.40.61.0-0.9-0.90.80.4-0.41.00.8
Time in closed arm before self-admin2.93.34.5-1.8-1.92.11.5-1.91.71.6
Time in closed arm after self-admin0.10.10.2-0.30.1-0.10.3-0.00.30.5
Time in open arm before self-admin0.10.10.4-0.3-0.30.30.6-0.40.10.4
Time in open arm after self-admin0.10.10.30.2-0.60.4-0.2-0.50.1-0.4
Bone: periosteal estimation2.75.56.52.52.2-2.3-2.52.4-2.2-2.3
Bone: periosteal perimeter3.55.86.82.52.4-2.4-2.52.6-2.2-2.3
Bone: post-yield work0.60.81.11.00.8-0.9-0.80.7-0.9-1.1
Progressive ratio test 1 active lever presses0.00.00.10.00.3-0.20.00.3-0.20.2
Progressive ratio test 1 breakpoint0.10.10.3-0.3-0.00.20.3-0.10.00.6
Progressive ratio test 1 inactive lever presses0.00.00.00.20.0-0.20.00.1-0.2-0.2
Progressive ratio test 2 active lever presses0.10.10.30.3-0.00.0-0.5-0.1-0.5-0.3
Progressive ratio test 2 breakpoint0.10.10.40.40.1-0.2-0.50.1-0.6-0.3
Progressive ratio test 2 inactive lever presses0.00.00.10.1-0.30.2-0.1-0.3-0.1-0.0
Incentive Sensitization - Responses0.50.51.10.80.1-0.3-1.00.2-0.9-1.0
Incentive Sensitization - Breakpoint0.70.71.30.90.3-0.5-1.20.3-1.0-1.1
Sum of active levers in priming session hrs 5-60.00.00.10.1-0.2-0.1-0.0-0.10.3-0.2
Progressive ratio0.00.00.1-0.3-0.2-0.10.3-0.1-0.00.2
Food seeking constrained by brief footshock0.70.91.30.91.1-1.0-0.91.2-0.8-0.7
Seeking ratio, punishment vs. effort0.30.30.50.60.7-0.4-0.70.6-0.3-0.5
Retroperitoneal fat weight1.13.75.51.62.3-2.2-1.92.3-1.8-1.3
Reaction time number correct1.52.12.8-1.4-1.51.71.3-1.41.51.5
Reaction time mean minus median0.30.40.70.60.8-0.8-0.30.4-0.8-0.7
Reaction time mean minus median AUC0.81.01.51.01.1-1.1-0.80.6-1.0-1.2
Reaction time num false alarms0.00.00.10.20.2-0.2-0.10.20.10.1
Reaction time num false alarms AUC0.00.00.10.30.3-0.2-0.10.30.20.1
Reaction time trials correct on left1.52.12.8-1.4-1.51.71.3-1.41.51.5
Reaction time trials on left1.62.22.9-1.4-1.51.71.3-1.41.61.5
Reaction time mean0.00.00.0-0.20.10.00.2-0.20.10.0
Reaction time mean AUC0.00.00.1-0.20.00.10.1-0.20.10.0
Median of all reaction times0.10.10.2-0.5-0.20.40.3-0.40.30.3
Reaction time omissions0.20.20.5-0.4-0.20.20.6-0.60.70.3
Reaction time false alarm rate0.40.50.80.80.9-0.9-0.60.7-0.6-0.6
Reaction time premature initiation rate0.00.00.10.0-0.1-0.0-0.20.3-0.20.1
Reaction time premature initiations0.20.30.5-0.6-0.70.70.4-0.30.40.7
Std. dev. reaction times0.30.41.00.51.0-0.9-0.40.6-0.5-0.5
Reaction time trials completed1.62.22.9-1.4-1.51.71.3-1.41.61.5
Reaction time trials AUC1.21.72.3-1.2-1.31.51.1-1.21.41.3
Run reversals in cocaine runway, females1.71.62.5-1.6-1.11.31.2-0.91.21.4
Run reversals in cocaine runway, males1.31.31.61.11.1-1.2-0.91.1-1.3-1.2
Latency to leave start box in cocaine runway0.40.40.60.80.4-0.4-0.80.5-0.7-0.8
Latency to leave start box in cocaine runway, F0.10.10.3-0.0-0.50.4-0.0-0.40.0-0.1
Latency to leave start box in cocaine runway, M1.41.31.61.31.2-1.1-1.11.1-1.1-1.1
Std. dev. time between licks in bursts0.60.81.2-1.0-0.80.70.8-0.71.01.1
Total sessions with >9 infusions0.50.60.90.60.8-0.9-0.71.0-0.7-0.5
Short access day 1 total inactive lever presses2.52.83.41.91.6-1.7-1.81.6-1.4-1.8
Short access day 10 total inactive lever presses2.83.13.91.91.6-1.6-1.81.6-1.7-2.0
Short access day 1 total infusions1.41.51.91.21.1-1.2-1.41.2-1.2-1.3
Short access day 10 total infusions0.10.10.4-0.1-0.00.10.40.00.20.6
Short access total infusions1.01.21.31.11.1-1.1-1.11.2-1.0-1.0
Short access day 1 locomotion0.00.00.1-0.0-0.30.2-0.1-0.20.3-0.2
Short access day 10 total locomotion0.91.01.5-0.9-0.90.81.2-1.01.21.0
Short access total locomotion0.10.10.1-0.00.2-0.20.20.10.40.3
One hour access (0.3 mA shock)0.30.40.8-0.4-0.80.70.3-0.90.50.4
Compulsive drug intake0.40.40.8-0.4-0.60.60.5-0.70.90.4
One hour access (shock baseline)0.20.30.6-0.3-0.80.60.3-0.70.20.3
Social response proportion0.20.30.50.40.6-0.6-0.30.4-0.5-0.7
Social responses0.10.10.2-0.50.1-0.00.30.10.50.4
Social time2.23.03.8-1.9-1.61.61.8-1.61.91.5
Soleus weight0.10.20.40.50.1-0.2-0.40.1-0.6-0.6
Bone: stiffness1.01.62.11.41.3-1.4-1.21.3-1.1-1.2
Tibialis anterior weight0.41.42.1-1.0-1.01.01.5-1.41.01.2
Time to tail flick, vehicle, before self-admin0.20.20.40.30.6-0.5-0.20.5-0.3-0.2
Time to tail flick, vehicle, after self-admin0.30.30.5-0.5-0.30.50.7-0.70.70.4
Time to tail flick, test, before self-admin0.00.00.10.20.2-0.1-0.30.2-0.1-0.1
Time to tail flick, test, after self-admin3.03.13.8-1.6-1.91.81.6-1.91.91.6
Delta time to tail flick, vehicle, before/after SA0.00.00.10.1-0.20.0-0.2-0.30.1-0.2
Delta time to tail flick, test, before/after SA3.22.84.0-1.6-2.01.71.5-1.91.71.5
Tibia length0.92.63.31.61.7-1.8-1.51.8-1.5-1.2
Ambulatory time before self-admin0.10.10.3-0.0-0.30.2-0.3-0.10.0-0.6
Ambulatory time after self-admin0.30.30.80.40.3-0.3-0.70.3-0.5-0.9
Bone: tissue strength0.40.40.50.70.6-0.7-0.70.7-0.4-0.6
Total heroin consumption0.30.40.60.80.4-0.6-0.50.6-0.7-0.6
Bone: trabecular number0.10.10.2-0.4-0.50.40.2-0.30.20.4
Bone: trabecular spacing0.81.01.31.01.1-1.0-0.91.0-0.8-1.0
Bone: trabecular thickness0.30.40.7-0.8-0.50.60.3-0.40.60.8
Bone: trabecular tissue density0.70.91.4-0.9-0.80.71.2-1.01.01.1
Water consumed over 24 hours4.35.26.32.42.1-2.1-2.32.0-2.4-2.5
Number of responses in last shaping day0.80.81.0-0.9-0.91.00.8-0.80.71.0