Hub : Genes

Ttl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA alternative TSS NM_138536.2 0.09 0.06 5.0e-04 0.06 0.06 0.05 0.06 5.2e-04 3.2e-04 8.3e-04 4.7e-04
2 Adipose gene expression Ttl 0.29 0.13 0.0e+00 0.17 0.2 0.2 0.2 1.6e-18 7.8e-22 9.1e-22 8.4e-22
3 BLA alternative TSS XM_039104213.1 0.08 0.06 6.0e-04 0.06 0.06 0.05 0.06 5.5e-04 3.9e-04 1.3e-03 5.0e-04
4 PL gene expression Ttl 0.08 0.05 3.8e-07 0.07 0.06 0.06 0.06 2.8e-08 5.1e-07 2.9e-07 1.6e-07
5 Brain alternative TSS NM_138536.2 0.2 0.1 0.0e+00 0.2 0.19 0.19 0.19 2.3e-18 3.6e-17 4.7e-17 1.8e-17
6 Brain alternative TSS XM_039104213.1 0.2 0.1 0.0e+00 0.2 0.19 0.19 0.19 1.9e-18 5.0e-17 3.5e-17 1.3e-17
7 NAcc mRNA stability Ttl 0.05 0.04 2.5e-05 0.04 0.04 0.04 0.04 9.5e-06 1.3e-05 1.7e-05 1.5e-05
8 Liver alternative TSS NM_138536.2 0.06 0.04 1.0e-05 0.03 0.01 0.01 0 1.7e-04 5.0e-02 6.1e-02 8.0e-02
9 NAcc alternative TSS NM_138536.2 0.03 0.02 2.4e-03 0.03 0.02 0.01 0.03 3.7e-04 2.0e-03 8.3e-03 3.1e-04
10 Brain gene expression Ttl 0.06 0.04 2.8e-04 0.03 0.03 0.03 0.03 1.0e-03 1.1e-03 1.2e-03 1.6e-03
11 NAcc alternative TSS XM_039104213.1 0.03 0.02 2.7e-03 0.03 0.02 0.02 0.03 5.3e-04 2.0e-03 5.5e-03 4.2e-04
12 NAcc gene expression Ttl 0.06 0.04 5.4e-07 0.06 0.06 0.05 0.05 3.0e-07 4.3e-07 3.0e-06 6.4e-07
13 BLA gene expression Ttl 0.15 0.11 9.0e-06 0.06 0.07 0.03 0.07 2.5e-04 9.9e-05 7.3e-03 1.9e-04
14 Adipose mRNA stability Ttl 0.05 0.04 1.1e-04 0.01 0.01 0.01 0.01 8.3e-03 6.8e-03 1.5e-02 1.0e-02
15 Eye mRNA stability Ttl 0.38 0.2 6.7e-03 0.06 0.01 0.01 0.07 4.2e-02 2.0e-01 2.0e-01 3.1e-02
16 IL gene expression Ttl 0.23 0.18 4.1e-03 0.01 -0 0.01 0.01 1.8e-01 3.4e-01 1.4e-01 2.1e-01
17 LHb gene expression Ttl 0.21 0.14 8.5e-03 0.05 0 0 0.05 2.5e-02 2.4e-01 2.5e-01 2.6e-02
18 PL alternative TSS XM_039104213.1 0.03 0.02 8.8e-04 0.03 0.03 0.04 0.03 1.7e-04 7.3e-04 8.0e-05 1.0e-04
19 PL alternative TSS NM_138536.2 0.03 0.02 8.4e-04 0.03 0.03 0.04 0.03 1.6e-04 7.5e-04 8.1e-05 1.1e-04
20 Brain mRNA stability Ttl 0.12 0.07 8.3e-09 0.08 0.09 0.09 0.09 1.5e-07 6.0e-09 7.5e-09 1.9e-08
21 Liver gene expression Ttl 0.13 0.07 1.9e-11 0.04 0.08 0.08 0.08 8.5e-05 1.7e-09 3.5e-09 3.8e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density2.33.85.3-2.12.12.1-2.22.3-2.3-2.22.1-2.1-1.72.1-1.91.91.72.1-2.01.6-1.91.90.90.3
Area under the delay curve0.40.40.80.6-0.6-0.60.5-0.70.70.7-0.70.90.5-0.90.7-0.5-0.5-0.70.4-0.80.8-0.8-0.3-0.2
BMI with tail0.62.05.3-1.41.81.3-1.21.1-1.1-1.11.3-1.1-2.21.1-0.80.02.21.0-0.71.6-1.01.02.32.1
BMI without tail2.34.811.2-2.12.82.0-2.01.9-1.9-1.81.9-1.8-3.31.8-1.60.43.11.5-1.92.7-1.51.53.12.8
Body weight3.815.727.0-4.45.04.3-4.14.1-4.1-3.73.8-3.6-5.23.6-3.52.15.13.4-3.04.5-3.33.24.43.5
Weight adjusted by age5.56.29.7-2.82.72.8-2.92.9-2.9-2.82.7-2.6-2.22.5-2.62.62.02.5-3.12.2-2.32.20.90.1
Bone surface1.62.83.9-1.81.71.8-1.92.0-2.0-2.01.8-1.9-1.31.9-1.71.71.31.9-1.71.3-1.71.70.60.1
Bone volume1.83.14.4-1.91.81.9-2.02.1-2.1-2.11.9-2.0-1.42.0-1.81.91.42.0-1.81.2-1.81.80.60.0
Breakpoint value in progressive ratio session0.70.82.0-0.70.90.7-0.60.5-0.5-0.50.4-0.9-1.11.0-0.9-0.21.30.60.31.2-1.01.01.41.3
Number of licking bursts0.50.66.70.20.5-0.2-0.40.4-0.4-0.6-0.10.0-0.8-0.11.1-0.30.2-0.2-2.60.80.7-0.80.40.8
Context. condit. distance diff. score2.73.313.0-1.71.71.7-2.22.1-2.1-2.61.5-2.1-1.12.0-1.12.10.81.9-3.61.2-1.51.4-0.1-0.6
Locomotion velocity, session 10.20.22.70.0-0.40.00.4-0.40.40.30.2-0.10.50.1-0.6-0.0-0.20.21.6-0.5-0.50.5-0.2-0.4
Locomotion distance, session 11.41.83.2-1.51.21.6-1.51.5-1.5-1.41.5-1.5-0.71.5-1.51.80.71.5-1.00.6-1.51.5-0.1-0.6
Locomotion velocity, session 20.10.10.30.2-0.3-0.20.5-0.50.50.5-0.20.30.1-0.30.0-0.3-0.2-0.30.6-0.50.2-0.1-0.0-0.0
Locomotion distance, session 22.83.96.1-2.42.02.4-2.22.1-2.1-1.92.4-2.2-1.52.2-2.52.21.62.2-0.91.1-2.42.40.6-0.2
Locomotion velocity, session 30.40.52.5-0.40.80.3-0.10.1-0.1-0.20.1-0.1-1.40.10.0-0.61.10.1-0.31.3-0.00.01.51.6
Locomotion distance, session 33.94.210.5-2.12.62.0-1.71.7-1.7-1.51.8-1.4-3.21.4-1.40.33.01.4-0.93.1-1.31.33.12.8
Stereotopy head waving bouts, day 30.91.16.00.4-1.1-0.30.2-0.20.2-0.3-0.3-0.31.90.3-0.31.0-1.60.2-0.0-1.8-0.30.3-2.3-2.4
Stereotopy head waving duration, day 30.80.92.90.9-1.3-0.80.8-0.80.80.1-0.90.11.7-0.10.30.0-1.5-0.20.4-1.50.2-0.2-1.6-1.6
Locomotion velocity, session 71.82.06.2-1.41.71.4-1.71.6-1.6-1.71.1-1.3-1.71.2-0.81.21.31.2-2.51.6-0.90.80.90.6
Locomotion distance, session 74.76.013.3-2.52.62.5-3.02.8-2.8-3.02.5-2.7-2.02.6-1.92.61.72.6-3.62.1-2.22.20.6-0.0
Stereotopy head waving bouts, day 70.20.20.50.3-0.2-0.30.6-0.50.50.5-0.50.4-0.2-0.40.2-0.70.2-0.40.70.10.3-0.20.60.7
Stereotopy head waving duration, day 70.70.92.50.9-0.8-1.01.3-1.21.21.1-1.01.00.3-0.90.7-1.4-0.3-0.91.6-0.50.8-0.80.40.7
Locomotion velocity, session 80.91.11.8-1.21.01.2-1.11.1-1.1-1.11.3-1.2-0.81.2-1.21.20.81.2-0.90.6-1.21.20.2-0.2
Locomotion distance, session 87.410.915.9-3.63.43.6-3.83.7-3.7-4.03.5-3.7-2.53.7-3.13.72.43.7-3.92.3-3.43.30.8-0.3
Degree of sensitization distance1.31.35.0-0.2-0.20.3-0.90.8-0.8-1.20.3-0.91.10.9-0.31.7-1.10.8-2.1-1.0-0.60.5-2.0-2.2
Degree of sensitization stereotypy0.60.63.6-0.10.50.00.3-0.20.20.4-0.10.3-1.3-0.20.1-1.11.1-0.20.71.00.1-0.11.71.9
Conditioned locomotion3.03.55.4-2.11.72.1-1.92.0-2.0-2.12.1-2.3-1.12.3-2.32.01.42.3-0.71.2-2.32.30.5-0.3
Cocaine response after cond. corrected0.10.10.40.1-0.3-0.00.1-0.10.10.10.00.00.40.0-0.20.3-0.40.00.2-0.5-0.10.1-0.6-0.7
Cocaine response after cond. not corrected0.20.20.90.3-0.5-0.20.4-0.40.40.6-0.10.30.6-0.3-0.10.0-0.5-0.21.0-0.80.0-0.0-0.6-0.6
Cocaine response before conditioning0.40.52.60.5-0.6-0.50.7-0.80.81.0-0.40.70.6-0.70.2-0.6-0.3-0.61.6-0.60.4-0.4-0.10.0
Saline control response3.24.26.3-2.42.52.4-2.32.2-2.2-1.91.9-1.9-2.41.9-2.31.52.41.9-0.92.4-1.91.91.91.3
Bone: connectivity density1.21.92.7-1.51.51.5-1.61.6-1.6-1.71.5-1.6-1.11.6-1.31.41.21.5-1.51.1-1.41.40.60.2
Bone: cortical apparent density0.30.33.10.2-0.1-0.20.6-0.50.50.6-0.30.3-0.1-0.3-0.1-0.90.4-0.21.80.1-0.00.00.80.9
Bone: cortical area2.03.14.7-2.12.12.1-1.81.8-1.8-1.42.0-1.6-2.21.6-2.01.32.11.6-0.71.7-1.71.71.61.1
Bone: cortical porosity2.12.35.41.5-1.2-1.62.0-2.02.01.6-1.71.60.2-1.61.5-2.3-0.4-1.51.6-0.61.5-1.50.71.3
Bone: cortical porosity1.41.54.51.1-0.7-1.21.6-1.51.51.2-1.31.2-0.3-1.21.2-2.10.2-1.21.30.11.1-1.11.21.7
Bone: cortical thickness0.50.81.8-1.00.91.0-0.60.5-0.5-0.41.2-0.8-0.90.9-1.30.31.20.91.00.5-1.21.21.10.8
Bone: cortical thickness0.10.10.5-0.20.30.2-0.0-0.10.10.30.00.2-0.5-0.1-0.3-0.30.5-0.10.70.1-0.00.00.70.6
Bone: cortical tissue density0.30.43.00.3-0.3-0.30.6-0.60.60.7-0.40.40.0-0.30.0-0.90.3-0.31.7-0.00.1-0.10.70.8
Condit. Reinf. active minus inactive responses0.30.30.7-0.50.50.5-0.30.3-0.3-0.30.8-0.5-0.50.5-0.7-0.10.80.50.70.6-0.70.70.80.7
Condit. Reinf. active-inactive response ratio0.91.02.0-1.10.91.1-0.90.9-0.9-0.91.4-1.1-0.71.1-1.30.80.91.10.00.9-1.21.20.60.2
Condit. Reinf. active responses0.10.10.3-0.30.30.3-0.10.1-0.1-0.10.4-0.2-0.30.2-0.4-0.10.50.20.60.1-0.40.40.50.5
Condit. Reinf. inactive responses0.00.10.50.0-0.10.00.1-0.10.10.00.0-0.00.20.0-0.10.2-0.30.0-0.0-0.7-0.10.1-0.4-0.4
Incentive salience index mean0.30.30.9-0.60.50.6-0.60.5-0.5-0.31.0-0.5-0.30.5-0.80.50.50.60.40.3-0.70.70.30.1
Condit. Reinf. lever presses0.10.10.3-0.30.40.3-0.40.4-0.4-0.10.6-0.1-0.30.1-0.10.40.20.1-0.3-0.1-0.10.10.1-0.0
Condit. Reinf. active minus inactive responses3.13.95.8-2.42.32.4-2.32.3-2.3-1.72.2-1.8-2.01.9-2.32.02.01.9-0.72.0-2.02.01.10.4
Condit. Reinf. active-inactive response ratio3.53.75.3-2.22.32.2-2.22.2-2.2-1.92.1-1.8-2.11.8-1.81.71.91.8-1.72.3-1.71.71.30.7
Condit. Reinf. active responses3.54.97.5-2.72.62.7-2.42.4-2.4-1.72.3-2.0-2.32.1-2.72.02.42.1-0.22.4-2.32.31.60.8
Condit. Reinf. inactive responses0.50.61.6-1.00.81.0-0.80.8-0.8-0.50.6-0.7-0.70.8-1.30.80.80.80.50.5-0.91.00.50.1
Condit. Reinf. lever presses0.81.12.3-1.31.41.2-1.21.2-1.2-0.31.0-0.5-1.50.5-1.10.61.50.50.21.5-0.60.61.31.0
Condit. Reinf. lever reinforcers received3.04.26.5-2.52.42.5-2.32.4-2.4-1.72.2-1.9-2.11.9-2.52.02.21.9-0.42.1-2.12.11.40.6
Conditioned reinforcement - actives0.50.50.9-0.81.00.8-0.80.8-0.8-0.80.7-0.6-0.90.6-0.50.40.90.6-0.70.7-0.40.40.80.6
Conditioned reinforcement - inactives4.24.78.6-2.52.02.5-2.62.6-2.6-2.62.8-2.3-1.12.3-2.22.91.22.5-2.10.6-2.12.1-0.1-1.0
Conditioned locomotion0.30.31.2-0.60.80.6-0.70.7-0.7-0.60.6-0.4-0.70.4-0.20.50.60.4-1.10.6-0.20.20.50.3
Patch foraging indifference point 0 sec0.50.82.8-1.00.51.0-1.01.0-1.0-0.51.0-0.70.00.8-1.41.7-0.00.8-0.20.0-0.90.9-0.8-1.3
Patch foraging indifference point AUC0.30.40.8-0.60.60.6-0.40.5-0.5-0.70.9-0.8-0.70.8-0.80.40.60.6-0.50.6-0.60.60.40.2
Delay disc. indifference point, 0s delay4.54.99.72.4-2.5-2.42.4-2.32.32.5-2.42.32.3-2.22.1-1.7-2.2-2.12.1-3.11.9-1.9-1.6-1.0
Delay disc. indifference point, 16s delay0.50.51.10.7-0.7-0.70.5-0.60.60.7-0.60.90.6-1.00.7-0.4-0.7-0.90.4-0.91.0-1.0-0.5-0.4
Delay disc. indifference point, 2s delay0.10.10.50.3-0.3-0.30.1-0.30.30.3-0.50.40.3-0.40.6-0.1-0.4-0.2-0.0-0.70.4-0.3-0.3-0.3
Delay disc. indifference point, 24s delay1.11.11.61.0-1.2-1.01.1-1.11.11.1-0.91.31.1-1.30.9-0.5-1.1-1.10.7-1.11.2-1.2-0.9-0.7
Delay disc. indifference point, 4s delay0.20.20.50.4-0.2-0.40.3-0.50.50.6-0.60.5-0.1-0.50.6-0.70.1-0.40.4-0.60.4-0.40.40.6
Delay disc. indifference point, 8s delay0.50.51.40.6-0.4-0.60.5-0.70.70.6-0.81.00.2-1.10.9-0.8-0.3-0.80.2-0.31.2-1.20.10.4
Indifference point function ln k0.60.81.3-1.00.81.0-1.01.1-1.1-0.90.8-1.0-0.51.0-1.01.20.51.0-0.70.3-1.01.00.0-0.3
Indifference point function log k0.60.81.3-1.00.81.0-1.01.1-1.1-0.90.8-1.0-0.51.0-1.01.20.51.0-0.70.3-1.01.00.0-0.3
Patch foraging total patch changes 0 sec0.60.93.1-1.00.51.1-1.11.1-1.1-0.61.1-0.90.00.9-1.41.7-0.00.9-0.3-0.0-1.11.1-0.9-1.4
Patch foraging total patch changes 12 sec0.00.10.5-0.0-0.10.00.3-0.20.20.3-0.0-0.0-0.00.0-0.5-0.00.00.10.70.1-0.30.40.0-0.1
Patch foraging total patch changes 18 sec0.40.53.10.2-0.6-0.10.1-0.00.0-0.00.1-0.11.00.1-0.20.9-1.10.2-0.8-0.8-0.30.3-1.6-1.8
Patch foraging total patch changes 24 sec0.81.05.9-0.1-0.40.2-0.50.4-0.4-0.40.7-0.31.20.3-0.51.7-1.3-0.0-1.3-1.10.0-0.1-2.2-2.4
Patch foraging total patch changes 6 sec0.91.43.0-1.31.01.3-1.31.4-1.4-1.21.5-1.3-0.51.3-1.61.70.51.1-0.80.6-1.21.2-0.3-0.8
Patch foraging time to switch 0 sec4.06.18.52.8-2.5-2.82.8-2.82.82.8-2.72.91.8-2.92.9-2.8-1.9-2.72.0-1.42.6-2.6-0.70.2
Patch foraging water rate 0 sec5.99.512.8-3.43.13.4-3.43.4-3.4-3.53.5-3.6-2.43.6-3.53.22.53.4-2.62.1-3.43.41.10.0
Patch foraging water rate 12 sec1.31.93.6-1.51.51.6-1.81.7-1.7-1.61.8-1.5-1.01.4-1.31.80.91.3-1.90.6-1.11.10.1-0.3
Patch foraging water rate 18 sec0.40.50.8-0.80.90.8-0.90.8-0.8-0.60.7-0.6-0.90.6-0.70.40.90.7-0.30.6-0.60.60.70.6
Patch foraging water rate 24 sec0.50.81.2-0.91.10.8-0.91.0-1.0-0.90.9-0.8-1.10.7-0.40.41.00.8-1.11.0-0.60.60.90.8
Patch foraging water rate 6 sec1.72.53.7-1.91.91.8-1.71.7-1.7-1.61.6-1.7-1.81.7-1.91.31.71.4-1.11.3-1.51.51.20.7
Seeking ratio, delayed vs. immediate footshock0.10.20.50.4-0.5-0.40.4-0.30.30.2-0.40.30.5-0.30.3-0.1-0.5-0.40.2-0.70.4-0.4-0.5-0.5
Distance traveled before self-admin6.36.69.1-2.82.72.8-2.82.9-2.9-2.92.4-3.0-2.33.0-2.72.52.22.7-2.42.3-2.82.71.20.4
Distance traveled after self-admin2.93.25.0-1.82.01.8-1.91.9-1.9-2.01.4-2.0-2.02.0-1.21.21.81.8-2.21.9-1.81.81.41.0
Extensor digitorum longus weight0.10.31.6-0.30.70.2-0.40.3-0.3-0.40.2-0.2-1.00.10.3-0.20.70.1-1.30.80.1-0.10.91.0
Bone: elastic displacement0.70.82.50.8-0.4-0.81.0-0.90.90.9-1.10.9-0.3-0.90.9-1.60.2-0.90.70.41.0-1.01.01.4
Bone: elastic work0.20.31.00.4-0.1-0.40.6-0.40.40.4-0.50.4-0.3-0.40.5-1.00.3-0.40.30.40.4-0.40.81.0
Bone: endosteal estimation0.92.09.0-1.41.71.4-1.71.7-1.7-1.61.0-1.2-1.61.1-0.71.41.11.0-3.01.7-0.70.60.60.3
Bone: endosteal perimeter1.93.96.0-2.32.42.3-2.42.4-2.4-1.81.9-1.7-2.11.7-2.01.92.01.7-1.72.3-1.61.61.20.6
Epididymis fat weight0.41.02.1-1.01.21.0-0.90.9-0.9-0.90.8-0.8-1.40.8-0.90.31.30.7-0.61.4-0.70.71.31.1
Delta time in closed arm before/after self-admin0.30.30.50.6-0.6-0.60.6-0.60.60.7-0.70.60.4-0.60.6-0.4-0.6-0.60.1-0.70.5-0.5-0.4-0.3
Delta time in open arm before/after self-admin2.12.03.6-1.51.41.5-1.51.5-1.5-1.51.5-1.9-1.01.9-1.81.31.11.4-0.71.1-1.81.80.60.1
Diff in mean of infusions in LGA sessions1.11.22.01.3-1.2-1.31.0-1.21.21.1-1.21.11.0-1.11.1-1.0-1.0-1.31.4-0.81.2-1.2-0.6-0.2
Delay discount exponential model param0.40.40.9-0.60.60.6-0.50.7-0.7-0.80.7-0.9-0.51.0-0.70.50.50.7-0.50.7-0.90.90.20.1
Extinction: sum of active levers before priming0.10.11.30.1-0.1-0.10.3-0.30.30.2-0.1-0.3-0.10.3-0.3-0.50.3-0.01.20.1-0.40.40.50.5
Active lever presses in extinction session 60.10.10.70.1-0.4-0.10.0-0.00.00.1-0.20.10.6-0.1-0.10.3-0.5-0.10.4-0.50.1-0.1-0.7-0.8
Bone: final force2.84.56.1-2.42.52.4-2.22.2-2.2-2.22.2-2.2-2.42.2-2.11.62.32.2-1.82.2-2.12.11.71.1
Bone: final moment2.23.55.0-2.12.22.1-2.02.0-2.0-1.91.9-1.9-2.21.9-1.81.42.01.9-1.82.0-1.81.81.51.0
Food consumed during 24 hour testing period0.20.31.20.4-0.6-0.40.1-0.10.1-0.0-0.20.10.9-0.20.40.3-0.9-0.2-0.6-0.60.3-0.3-1.1-1.0
Glucose0.30.41.1-0.70.80.7-0.80.7-0.7-0.70.7-0.6-0.70.6-0.50.70.50.5-1.00.8-0.40.40.30.1
Heart weight6.28.712.1-3.33.13.3-3.33.4-3.4-3.53.3-3.3-2.53.3-3.03.02.53.1-3.22.0-2.92.81.30.3
Delay discount hyperbolic model param0.40.40.8-0.60.60.6-0.50.7-0.7-0.80.7-0.9-0.40.9-0.70.50.50.7-0.50.7-0.80.80.20.1
Intermittent access intake day 1-15 change2.62.54.1-1.71.81.6-1.61.6-1.6-2.01.7-1.9-1.61.8-1.21.11.61.8-1.91.1-1.61.61.20.8
Intermittent access intake escalation1.91.93.2-1.41.61.4-1.41.4-1.4-1.81.5-1.6-1.31.5-1.01.01.41.5-1.61.0-1.31.31.00.7
Intermittent access intake escalation 20.60.60.9-0.70.80.7-0.70.7-0.7-1.00.9-1.0-0.60.9-0.60.50.70.9-0.80.4-0.90.80.50.3
Intermitt. access day 1 inactive lever presses1.71.83.4-1.61.41.6-1.61.6-1.6-1.61.8-1.3-0.91.3-1.21.71.01.4-1.60.7-1.11.10.2-0.3
Intermitt. access day 15 inactive lever presses2.12.26.0-1.51.11.6-1.91.9-1.9-1.81.7-1.5-0.31.5-1.22.50.21.5-2.10.2-1.21.2-1.0-1.6
Intermitt. access escalation Index1.31.22.11.2-1.0-1.21.4-1.41.41.2-1.11.20.6-1.31.2-1.4-0.6-1.10.8-0.61.2-1.20.10.5
Intermittent access day 1 total infusions0.40.51.20.7-0.6-0.70.6-0.60.60.6-0.60.90.6-0.90.7-0.4-0.6-0.90.4-0.51.1-1.1-0.4-0.3
Intermittent access day 15 total infusions0.70.81.5-1.01.11.0-1.01.0-1.0-1.21.1-0.9-0.80.9-0.60.80.90.8-1.20.5-0.60.60.50.3
Intermittent access terminal intake (last 3 days)0.80.91.7-1.00.91.1-1.21.2-1.2-1.31.3-1.2-0.41.1-0.91.20.61.0-1.00.2-0.90.90.0-0.3
Intermittent access total infusions0.30.30.8-0.50.40.6-0.70.7-0.7-0.80.7-0.60.00.6-0.40.90.10.5-0.7-0.2-0.30.3-0.4-0.6
Intermittent access day 1 locomotion0.20.21.2-0.40.50.4-0.60.6-0.6-0.60.5-0.3-0.40.3-0.10.50.30.2-1.10.80.0-0.00.1-0.0
Intermittent access day 15 total locomotion1.81.93.6-1.51.21.6-1.61.6-1.6-1.81.7-1.6-0.41.6-1.41.90.71.6-1.10.5-1.51.5-0.2-0.8
Intermittent access total locomotion1.11.23.1-1.21.21.2-1.41.4-1.4-1.51.3-1.2-0.71.1-0.71.30.71.0-1.80.8-0.80.70.1-0.2
Intermittent access standard deviation0.30.30.5-0.50.60.5-0.60.6-0.6-0.70.7-0.6-0.40.6-0.40.30.60.5-0.70.3-0.40.40.40.4
Left kidney weight1.43.96.5-2.32.02.3-2.42.5-2.5-2.32.3-2.1-1.22.1-2.22.51.31.9-2.01.0-1.71.70.1-0.6
Right kidney weight1.33.75.5-2.11.82.1-2.32.3-2.3-2.22.1-2.2-1.22.2-2.22.41.22.1-1.90.6-2.02.00.1-0.6
Cocaine induced anxiety3.13.611.71.7-2.3-1.61.3-1.31.31.3-1.31.43.0-1.41.40.4-3.0-1.40.5-1.31.4-1.4-3.4-3.2
Post-drug Anxiety1.41.53.91.2-1.5-1.11.0-1.01.01.0-1.01.11.9-1.11.1-0.0-1.9-1.00.6-0.71.1-1.1-2.0-1.8
Baseline Anxiety0.60.72.2-0.71.00.7-0.60.6-0.6-0.60.6-0.6-1.20.6-0.5-0.21.30.7-0.20.4-0.60.61.51.4
Tail length2.88.518.0-3.03.82.9-2.92.9-2.9-2.52.4-2.4-4.22.3-2.41.13.92.1-2.94.0-1.91.93.63.1
Length with tail3.011.115.9-3.84.03.8-3.73.8-3.8-3.43.4-3.3-3.73.3-3.42.83.63.1-2.83.5-2.92.92.51.6
Length without tail0.92.03.1-1.81.51.8-1.61.7-1.7-1.51.6-1.5-1.21.5-1.71.61.31.5-0.61.0-1.41.40.6-0.0
Times rat made contact with spout0.00.00.10.1-0.2-0.10.1-0.10.1-0.3-0.2-0.10.30.10.10.0-0.20.1-0.30.00.0-0.0-0.3-0.3
Lifetime Intake0.30.30.7-0.60.60.6-0.70.7-0.7-0.80.7-0.6-0.30.6-0.40.70.30.6-0.80.2-0.50.5-0.0-0.2
Liver weight, left0.91.44.6-1.00.81.1-1.51.5-1.5-1.21.2-1.1-0.11.1-0.81.9-0.11.1-2.1-0.0-0.90.9-1.0-1.4
Liver weight, right0.00.10.20.2-0.3-0.20.1-0.10.1-0.0-0.00.10.4-0.10.1-0.1-0.3-0.30.3-0.20.4-0.4-0.3-0.2
Locomotor activity0.50.81.7-0.90.90.9-0.60.6-0.6-0.80.6-1.0-1.11.0-0.90.31.11.1-0.81.3-1.21.21.00.8
Locomotor testing distance0.10.10.4-0.30.20.4-0.30.3-0.3-0.30.3-0.4-0.00.4-0.30.50.00.5-0.60.4-0.50.6-0.2-0.4
Locomotor testing rearing1.11.73.0-1.51.21.6-1.41.5-1.5-1.01.5-1.3-0.71.3-1.61.70.81.4-1.00.9-1.51.60.0-0.6
Locomotion in novel chamber0.40.53.1-0.60.80.5-0.60.7-0.7-0.50.4-0.3-1.10.3-0.10.20.70.5-1.81.3-0.30.30.70.7
Locomotion in novel chamber post-restriction0.70.92.9-0.81.00.8-0.60.6-0.6-0.60.6-0.7-1.40.8-0.7-0.11.40.8-0.31.7-0.90.91.51.4
Fecal boli incidents, locomotor time 10.20.20.60.4-0.2-0.40.4-0.50.50.4-0.40.20.1-0.20.5-0.80.1-0.30.70.30.2-0.20.40.6
Change in fecal boli incidents, locomotor task0.00.00.10.1-0.2-0.00.1-0.10.10.10.1-0.00.20.1-0.1-0.0-0.10.20.0-0.4-0.30.3-0.1-0.2
Time >=10cm from walls, locomotor time 10.20.21.4-0.10.50.1-0.2-0.10.1-0.1-0.00.0-0.9-0.10.2-0.60.70.0-0.40.30.1-0.11.11.2
Bouts of movement, locomotor time 14.65.08.72.3-2.6-2.32.6-2.42.42.6-1.92.42.4-2.41.7-1.9-2.1-2.22.9-3.02.0-1.9-1.4-0.9
Total resting periods, locomotor time 14.44.98.42.3-2.5-2.32.6-2.42.42.7-1.92.42.2-2.41.6-2.1-1.9-2.22.9-2.81.9-1.9-1.1-0.5
Rest time, locomotor task time 10.80.81.70.9-0.9-0.91.0-1.01.01.3-0.61.10.7-1.10.7-0.9-0.6-1.21.0-0.71.0-1.0-0.20.0
Distance moved, locomotor task time 10.00.00.1-0.10.10.1-0.1-0.00.0-0.20.1-0.2-0.20.20.00.10.10.10.00.1-0.20.2-0.0-0.0
Vertical activity count, locomotor time 10.30.30.8-0.50.60.5-0.70.7-0.7-0.80.5-0.7-0.60.7-0.10.60.30.6-0.90.6-0.60.60.1-0.0
Time >=10cm from walls, locomotor time 20.10.21.2-0.20.50.1-0.50.3-0.3-0.30.10.0-0.6-0.00.40.00.3-0.1-1.1-0.00.3-0.30.40.5
Bouts of movement, locomotor time 21.31.42.61.3-1.0-1.31.3-1.31.31.3-1.21.40.4-1.41.6-1.6-0.5-1.30.4-0.81.4-1.40.20.7
Total resting periods, locomotor time 21.51.63.41.3-0.9-1.41.4-1.41.41.4-1.21.50.3-1.51.5-1.8-0.4-1.40.6-0.71.5-1.50.51.0
Rest time, locomotor task time 20.91.02.90.9-0.9-0.91.3-1.31.31.3-0.61.10.6-1.10.5-1.5-0.2-1.11.7-0.40.9-0.90.40.7
Distance moved, locomotor task time 20.20.31.5-0.3-0.00.3-0.50.3-0.3-0.30.2-0.30.20.3-0.21.0-0.50.2-0.4-0.6-0.30.3-1.0-1.2
Vertical activity count, locomotor time 20.60.61.8-0.70.50.7-1.10.9-0.9-0.90.7-0.9-0.20.9-0.31.4-0.10.8-0.9-0.1-0.80.7-0.7-1.0
Light reinforcement 10.50.82.0-1.11.21.0-1.11.0-1.0-0.70.5-0.7-1.30.7-1.00.61.20.5-0.51.4-0.60.51.00.8
Light reinforcement 20.20.30.7-0.60.80.6-0.70.7-0.7-0.50.5-0.3-0.70.3-0.60.40.7-0.0-0.30.80.1-0.10.60.4
Bone: marrow area0.92.08.8-1.41.71.4-1.71.7-1.7-1.61.0-1.2-1.61.1-0.71.51.01.1-3.01.7-0.70.70.50.2
Bone: maximum diameter3.36.08.7-2.92.92.9-2.72.7-2.7-2.22.5-2.3-2.82.3-2.72.22.72.3-1.52.5-2.42.31.81.0
Bone: maximum force0.61.11.4-1.21.11.2-1.11.1-1.1-1.01.1-1.1-1.01.1-1.11.10.91.1-1.10.9-1.11.10.40.1
Bone: maximum moment0.30.51.1-0.80.80.9-0.90.9-0.9-0.70.7-0.7-0.70.7-0.70.90.50.7-1.10.6-0.70.60.2-0.1
Mean time between licks in bursts0.40.61.40.6-0.5-0.70.8-0.80.81.2-0.91.10.0-1.10.7-0.8-0.2-1.10.8-0.21.0-1.00.20.4
Mean num. licks in bursts0.50.65.2-0.2-0.60.20.2-0.20.20.30.1-0.21.00.3-1.20.6-0.50.42.3-0.9-0.80.8-0.8-1.2
Cd content in liver0.30.30.5-0.60.50.5-0.40.4-0.4-0.70.5-0.7-0.40.7-0.60.30.50.7-0.20.5-0.70.70.40.3
Co content in liver1.01.11.6-1.21.21.2-1.01.0-1.0-1.30.8-1.2-1.11.2-1.20.71.21.2-0.60.9-1.21.20.90.6
Cu content in liver0.91.02.2-1.11.21.1-0.90.9-0.9-0.80.8-0.9-1.30.9-1.10.31.50.90.21.3-0.90.91.41.2
Fe content in liver0.40.42.1-0.60.60.6-0.80.8-0.8-1.00.2-0.7-0.50.7-0.30.80.30.7-1.50.6-0.40.4-0.0-0.2
K content in liver0.10.11.2-0.30.20.3-0.10.1-0.10.30.5-0.0-0.30.1-0.60.00.40.11.1-0.0-0.30.30.40.3
Mg content in liver0.80.81.7-1.11.01.1-0.80.8-0.8-0.51.1-0.8-1.10.8-1.30.51.20.80.70.7-1.01.01.00.6
Mn content in liver0.91.02.1-1.21.21.2-0.90.9-0.9-0.51.1-0.7-1.40.7-1.20.41.40.80.41.2-0.90.91.31.0
Na content in liver0.10.10.50.1-0.3-0.1-0.00.0-0.00.30.00.30.5-0.30.00.4-0.5-0.20.1-0.50.2-0.2-0.7-0.7
Rb content in liver3.13.86.1-2.12.02.1-1.81.8-1.8-2.51.6-2.4-1.82.4-2.21.32.02.4-0.81.9-2.32.31.50.9
Se content in liver1.92.43.7-1.91.81.9-1.91.9-1.9-1.41.7-1.5-1.41.5-1.71.71.41.5-1.01.5-1.51.50.60.1
Sr content in liver0.70.72.0-0.81.20.8-1.11.1-1.1-0.60.5-0.4-1.30.4-0.30.51.00.3-1.40.8-0.20.10.90.8
Zn content in liver0.40.51.3-0.70.30.8-0.60.6-0.6-0.31.0-0.70.10.7-1.11.00.20.70.7-0.4-0.90.9-0.3-0.7
Bone: minimum diameter0.71.42.7-1.41.51.4-1.31.2-1.2-0.91.3-1.0-1.61.0-1.30.91.41.0-0.71.1-1.01.01.10.8
Time in familiar zone, hab. session 10.80.81.40.9-0.8-1.00.8-0.90.91.0-1.11.10.5-1.11.0-0.7-0.8-1.10.2-0.71.2-1.2-0.4-0.1
Time in novel zone, hab. session 11.21.22.1-1.00.71.1-1.11.2-1.2-1.41.2-1.4-0.11.4-1.21.30.41.4-0.60.5-1.41.4-0.2-0.6
Total zone transitions, hab. session 11.01.42.3-1.41.21.4-1.41.3-1.3-1.31.2-1.3-0.81.3-1.41.50.81.3-1.00.4-1.31.30.1-0.3
Total locomotion distance, hab. session 12.02.85.6-1.81.31.8-1.81.8-1.8-2.01.6-2.0-0.72.0-1.82.40.61.9-2.00.2-1.81.8-0.4-1.1
Locomotion velocity, hab. session 12.02.85.4-1.81.41.9-1.81.8-1.8-1.91.8-1.9-0.81.9-1.82.30.71.9-1.90.2-1.91.9-0.4-1.0
Time in familiar zone, hab. session 20.80.81.50.9-1.1-0.90.8-0.80.81.0-0.70.91.2-0.90.7-0.4-1.1-0.91.0-1.00.8-0.7-1.0-0.8
Time in novel zone, hab. session 20.70.71.6-0.81.00.8-0.70.7-0.7-1.00.6-0.9-1.30.9-0.60.31.10.8-1.11.0-0.70.71.00.8
Total zone transitions, hab. session 22.02.64.2-1.81.91.8-1.61.5-1.5-1.61.6-1.6-2.01.6-1.51.02.01.6-1.01.6-1.61.61.61.2
Total locomotion distance, hab. session 23.34.37.3-2.21.72.3-2.22.2-2.2-2.42.4-2.5-0.82.6-2.52.71.02.6-1.40.4-2.62.6-0.2-1.1
Locomotion velocity, hab. session 22.73.77.2-2.01.32.1-2.02.0-2.0-2.12.3-2.3-0.42.4-2.42.70.62.4-1.1-0.1-2.52.5-0.6-1.5
Novel to familiar place preference ratio0.20.21.0-0.1-0.00.1-0.30.4-0.4-0.50.1-0.30.30.3-0.10.7-0.40.3-1.0-0.4-0.20.2-0.8-0.9
Novelty place preference0.20.20.70.2-0.3-0.2-0.00.1-0.1-0.2-0.1-0.00.50.00.20.4-0.6-0.0-0.8-0.50.1-0.1-0.8-0.8
Time in novel zone, NPP test0.10.10.80.1-0.1-0.0-0.10.2-0.2-0.3-0.1-0.10.40.10.10.5-0.50.1-0.9-0.40.0-0.0-0.7-0.8
Total zone transitions, NPP test0.50.61.0-0.91.00.9-0.90.9-0.9-0.71.0-0.7-1.00.7-0.70.60.90.7-0.80.8-0.70.70.70.5
Total locomotion distance, NPP test3.34.68.4-2.31.82.3-2.52.5-2.5-2.52.5-2.5-0.92.5-2.32.90.92.5-2.20.6-2.42.4-0.4-1.2
Locomotion velocity, NPP test2.43.46.8-1.91.42.0-2.22.1-2.1-2.12.1-2.1-0.62.1-1.92.60.62.1-2.00.3-2.02.0-0.6-1.3
Intraocular pressure0.10.20.90.10.3-0.10.0-0.00.0-0.1-0.40.1-0.8-0.20.4-0.50.5-0.2-0.60.60.3-0.40.81.0
Delta distance traveled before/after self-admin0.40.41.20.7-0.4-0.70.7-0.60.60.7-0.70.60.1-0.51.1-1.0-0.1-0.70.5-0.10.5-0.50.40.7
Delta ambulatory time before/after self-admin3.13.45.32.2-1.9-2.22.1-2.02.02.1-2.02.01.4-1.92.3-2.0-1.5-2.11.4-1.61.9-1.9-0.60.1
Parametrial fat weight0.30.52.50.9-0.8-0.90.9-0.90.90.5-0.30.60.7-0.60.7-0.7-0.7-0.6-0.0-1.60.6-0.6-0.4-0.1
Pavlov. Cond. lever latency0.30.31.40.20.1-0.30.3-0.30.30.3-0.80.4-0.6-0.40.3-0.90.5-0.50.20.80.5-0.51.01.2
Pavlov. Cond. magazine entry latency0.60.82.5-1.00.81.0-1.01.0-1.0-0.71.6-0.9-0.40.9-0.91.20.50.9-0.40.1-1.01.0-0.0-0.4
Pavlov. Cond. change in total contacts0.30.30.9-0.60.50.6-0.80.8-0.8-0.40.9-0.5-0.10.5-0.40.90.20.5-0.50.1-0.50.5-0.2-0.4
Pavlov. Cond. index score0.20.21.0-0.40.20.5-0.50.5-0.5-0.21.0-0.40.20.4-0.50.8-0.10.40.1-0.4-0.60.6-0.4-0.7
Pavlov. Cond. latency score0.30.41.3-0.40.10.5-0.50.5-0.5-0.31.1-0.50.50.5-0.61.0-0.30.50.1-0.7-0.70.7-0.8-1.1
Pavlov. Cond. lever contacts0.30.31.1-0.50.30.6-0.60.7-0.7-0.31.1-0.50.20.5-0.60.90.00.60.1-0.4-0.70.7-0.5-0.7
Pavlov. Cond. magazine entry number0.20.30.70.5-0.7-0.50.5-0.40.40.0-0.90.10.8-0.10.2-0.0-0.8-0.2-0.1-0.60.3-0.3-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.20.20.5-0.50.60.5-0.40.4-0.4-0.50.1-0.5-0.70.5-0.50.10.60.5-0.40.5-0.40.40.60.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.8-0.30.20.4-0.40.4-0.4-0.10.9-0.20.20.2-0.40.6-0.00.30.2-0.3-0.40.4-0.3-0.5
Pavlov. Cond. response bias0.40.51.4-0.80.80.8-0.80.8-0.8-0.61.2-0.6-0.60.6-0.60.60.70.6-0.40.4-0.70.70.40.2
Pavlov. Cond. lever latency2.23.05.12.0-2.2-2.01.9-1.91.91.4-1.71.42.3-1.41.7-1.2-2.2-1.40.8-2.11.4-1.4-1.8-1.3
Pavlov. Cond. magazine entry latency0.10.10.3-0.40.40.4-0.60.6-0.60.00.6-0.0-0.30.0-0.30.60.20.0-0.20.4-0.10.1-0.1-0.2
Pavlov. Cond. change in total contacts1.21.63.3-1.51.71.5-1.31.3-1.3-0.61.3-0.7-1.80.8-1.30.61.80.80.21.8-0.90.91.61.3
Pavlov. Cond. index score1.41.83.7-1.61.81.6-1.51.5-1.5-0.71.4-0.8-1.90.8-1.20.81.80.9-0.31.9-0.90.91.61.2
Pavlov. Cond. latency score1.11.42.5-1.41.61.4-1.41.4-1.4-0.61.3-0.8-1.60.8-1.20.91.50.8-0.21.5-0.80.81.20.8
Pavlov. Cond. lever contacts2.23.05.0-2.12.22.0-2.02.0-2.0-1.31.7-1.4-2.21.4-1.81.22.21.4-0.72.0-1.41.41.71.2
Pavlov. Cond. magazine entry number0.30.41.20.7-0.9-0.70.7-0.70.70.1-0.80.21.0-0.20.4-0.3-0.9-0.20.3-1.10.2-0.2-0.8-0.7
Pavlov. Cond. intertrial magazine entries0.20.22.00.2-0.2-0.2-0.20.2-0.2-0.5-0.3-0.20.50.20.30.4-0.50.1-1.4-0.30.1-0.1-0.7-0.7
Pavlov. Cond. lever-magazine prob. diff.1.11.42.8-1.41.61.4-1.31.3-1.3-0.51.2-0.6-1.70.6-1.10.71.60.70.01.6-0.80.81.41.1
Pavlov. Cond. response bias2.33.25.5-2.12.32.1-2.02.0-2.0-1.31.8-1.4-2.31.4-1.71.32.21.4-0.82.2-1.41.41.81.3
Time in closed arm before self-admin0.40.51.10.9-0.8-0.90.8-0.70.70.8-1.00.60.7-0.50.9-0.6-0.8-0.80.2-0.60.5-0.5-0.5-0.2
Time in closed arm after self-admin1.92.03.51.7-1.4-1.71.6-1.61.61.7-1.91.40.9-1.41.7-1.7-1.1-1.50.6-1.11.2-1.2-0.40.2
Time in open arm before self-admin0.30.30.90.5-0.3-0.50.4-0.50.50.5-0.50.80.2-0.90.8-0.5-0.3-0.7-0.0-0.20.9-0.9-0.00.2
Time in open arm after self-admin1.41.52.9-1.31.11.4-1.51.5-1.5-1.41.5-1.4-0.61.4-1.51.70.61.2-1.10.7-1.21.2-0.2-0.7
Bone: periosteal estimation1.83.76.0-2.22.42.2-2.22.2-2.2-1.91.8-1.7-2.41.7-1.71.62.11.7-2.22.2-1.51.51.51.0
Bone: periosteal perimeter2.23.75.2-2.32.32.3-2.22.2-2.2-1.82.1-1.9-2.01.9-2.21.82.01.9-1.21.9-1.91.91.30.6
Bone: post-yield work0.70.91.40.9-0.9-0.80.7-0.70.71.1-0.91.11.0-1.10.9-0.1-1.2-1.10.1-1.11.1-1.1-1.2-1.0
Progressive ratio test 1 active lever presses1.92.02.7-1.61.61.5-1.41.4-1.4-1.51.3-1.5-1.51.5-1.50.91.61.4-0.71.6-1.41.41.30.9
Progressive ratio test 1 breakpoint2.22.33.3-1.71.81.6-1.51.5-1.5-1.61.5-1.6-1.71.6-1.60.91.81.6-0.81.7-1.61.61.51.1
Progressive ratio test 1 inactive lever presses1.71.83.0-1.61.31.6-1.61.6-1.6-1.61.7-1.5-0.81.4-1.61.70.91.5-1.10.5-1.31.30.1-0.4
Progressive ratio test 2 active lever presses0.60.71.2-0.90.70.9-0.90.9-0.9-1.01.0-1.0-0.31.0-1.01.10.40.9-0.5-0.6-0.90.9-0.1-0.5
Progressive ratio test 2 breakpoint0.30.40.6-0.60.50.7-0.60.6-0.6-0.70.8-0.7-0.20.7-0.70.80.30.6-0.3-0.8-0.60.5-0.0-0.3
Progressive ratio test 2 inactive lever presses2.42.85.0-1.91.61.9-2.12.1-2.1-2.12.1-1.8-0.91.8-1.52.21.01.8-1.70.7-1.61.5-0.0-0.7
Incentive Sensitization - Responses0.10.11.1-0.00.00.00.1-0.10.10.10.10.2-0.0-0.20.10.00.0-0.30.1-1.00.3-0.30.00.0
Incentive Sensitization - Breakpoint0.10.11.70.0-0.1-0.00.1-0.10.10.00.10.20.2-0.20.10.1-0.2-0.30.0-1.30.4-0.4-0.2-0.3
Sum of active levers in priming session hrs 5-60.60.61.0-0.80.60.9-0.90.9-0.9-0.70.7-0.9-0.31.0-1.01.00.40.8-0.10.5-1.01.0-0.1-0.4
Progressive ratio4.55.27.52.6-2.7-2.52.5-2.52.52.4-2.32.32.7-2.32.0-1.6-2.7-2.41.6-2.02.2-2.2-2.1-1.5
Food seeking constrained by brief footshock1.62.04.2-1.30.81.4-1.31.4-1.4-1.41.5-1.8-0.11.8-1.92.00.21.7-0.6-0.3-2.02.0-0.8-1.4
Seeking ratio, punishment vs. effort5.46.69.0-3.02.83.0-2.82.8-2.8-2.82.8-2.9-2.42.9-2.72.42.43.0-1.51.6-2.92.91.40.5
Retroperitoneal fat weight0.10.21.4-0.20.20.2-0.40.5-0.5-0.50.4-0.2-0.00.10.20.5-0.10.0-1.2-0.60.2-0.2-0.3-0.4
Reaction time number correct0.20.30.9-0.60.40.6-0.70.8-0.8-0.50.5-0.6-0.10.6-0.70.90.10.6-0.3-0.2-0.60.7-0.4-0.6
Reaction time mean minus median0.60.82.01.0-1.2-1.00.8-0.80.80.6-0.50.61.4-0.60.8-0.3-1.3-0.70.2-1.10.7-0.7-1.2-1.0
Reaction time mean minus median AUC0.20.21.00.5-0.7-0.50.4-0.40.40.10.00.11.0-0.10.30.0-0.8-0.10.1-0.60.1-0.1-0.9-0.9
Reaction time num false alarms2.53.45.2-2.32.02.3-2.22.2-2.2-1.92.1-1.9-1.61.9-2.12.11.71.8-1.01.5-1.81.80.80.1
Reaction time num false alarms AUC1.82.54.0-2.01.82.0-1.81.9-1.9-1.41.7-1.5-1.71.5-1.91.51.71.4-0.41.7-1.51.51.10.5
Reaction time trials correct on left0.20.30.9-0.60.40.6-0.70.8-0.8-0.50.5-0.6-0.10.6-0.70.90.10.6-0.3-0.2-0.60.7-0.4-0.6
Reaction time trials on left0.30.41.0-0.70.50.7-0.80.8-0.8-0.60.5-0.7-0.10.7-0.81.00.20.7-0.3-0.1-0.70.7-0.3-0.6
Reaction time mean0.00.10.3-0.20.20.1-0.20.2-0.2-0.30.3-0.2-0.20.2-0.1-0.00.30.2-0.50.5-0.10.10.30.3
Reaction time mean AUC0.00.00.3-0.10.20.1-0.20.1-0.1-0.20.3-0.2-0.10.2-0.1-0.00.20.2-0.40.5-0.10.10.30.2
Median of all reaction times0.20.31.0-0.60.60.5-0.60.5-0.5-0.60.6-0.6-0.60.6-0.50.20.70.5-0.71.0-0.50.50.60.5
Reaction time omissions0.81.12.4-1.10.81.1-1.01.0-1.0-1.01.1-1.3-0.41.3-1.50.90.91.30.20.6-1.51.50.4-0.0
Reaction time false alarm rate1.01.42.3-1.51.41.5-1.31.3-1.3-1.01.4-1.1-1.31.1-1.41.01.41.0-0.11.4-1.11.11.00.5
Reaction time premature initiation rate0.20.20.8-0.20.60.1-0.30.4-0.4-0.40.1-0.1-0.80.00.2-0.20.6-0.2-0.90.40.4-0.40.70.8
Reaction time premature initiations0.10.20.6-0.40.50.3-0.50.6-0.6-0.50.2-0.3-0.60.3-0.10.30.40.2-0.80.0-0.0-0.00.20.2
Std. dev. reaction times0.10.10.4-0.30.40.3-0.30.3-0.3-0.50.6-0.4-0.30.4-0.2-0.00.40.3-0.50.4-0.30.30.50.4
Reaction time trials completed0.30.41.0-0.70.50.7-0.80.8-0.8-0.60.5-0.7-0.10.7-0.81.00.20.7-0.3-0.1-0.70.7-0.3-0.6
Reaction time trials AUC0.20.40.9-0.60.40.6-0.70.8-0.8-0.50.5-0.6-0.10.6-0.70.90.10.7-0.2-0.1-0.70.7-0.3-0.6
Run reversals in cocaine runway, females1.21.13.4-1.21.31.2-1.41.3-1.3-1.21.0-0.8-1.10.8-0.81.20.90.9-1.81.1-0.50.50.40.1
Run reversals in cocaine runway, males1.81.82.8-1.51.31.5-1.21.2-1.2-1.41.6-1.5-1.11.5-1.60.91.41.70.10.9-1.71.71.00.5
Latency to leave start box in cocaine runway1.41.52.51.2-1.4-1.21.3-1.41.41.5-1.11.41.2-1.41.0-0.9-1.2-1.31.6-1.31.1-1.1-0.9-0.6
Latency to leave start box in cocaine runway, F2.83.05.61.9-2.0-1.82.1-2.22.22.2-1.61.81.7-1.71.4-1.7-1.5-1.82.4-1.51.4-1.3-0.9-0.4
Latency to leave start box in cocaine runway, M0.30.31.3-0.50.30.6-0.80.8-0.8-0.50.3-0.20.10.2-0.41.1-0.20.3-0.6-0.4-0.00.0-0.7-0.9
Std. dev. time between licks in bursts0.70.91.7-1.01.21.0-1.11.1-1.1-1.00.5-0.8-1.20.8-0.70.71.00.8-1.31.2-0.60.60.80.6
Total sessions with >9 infusions0.10.10.50.2-0.0-0.20.3-0.30.3-0.0-0.30.1-0.1-0.10.5-0.40.1-0.1-0.20.70.3-0.30.30.5
Short access day 1 total inactive lever presses0.30.32.1-0.50.60.5-0.60.6-0.6-0.60.7-0.1-0.5-0.00.10.50.40.2-1.40.30.4-0.40.20.1
Short access day 10 total inactive lever presses1.01.15.6-0.3-0.30.4-0.60.6-0.6-0.50.8-0.41.00.4-0.21.7-1.20.5-1.5-1.8-0.50.5-2.0-2.4
Short access day 1 total infusions0.00.00.30.0-0.0-0.00.1-0.10.1-0.1-0.0-0.00.00.00.2-0.0-0.10.1-0.50.2-0.00.0-0.0-0.0
Short access day 10 total infusions0.10.10.20.3-0.2-0.30.2-0.20.20.0-0.30.30.3-0.30.3-0.2-0.2-0.2-0.0-0.30.5-0.5-0.1-0.0
Short access total infusions0.00.00.30.00.1-0.0-0.00.0-0.0-0.3-0.0-0.2-0.10.20.2-0.10.10.2-0.50.3-0.10.10.10.2
Short access day 1 locomotion0.10.10.50.2-0.4-0.20.2-0.20.2-0.3-0.1-0.10.60.10.20.2-0.50.2-0.2-0.2-0.00.0-0.7-0.7
Short access day 10 total locomotion0.80.92.9-0.91.10.9-0.90.9-0.9-1.00.8-0.9-1.00.9-0.50.41.10.8-1.01.7-0.70.71.00.8
Short access total locomotion0.70.71.8-0.80.80.8-0.80.8-0.8-1.20.8-1.0-0.51.0-0.70.70.60.9-1.11.3-0.80.80.30.1
One hour access (0.3 mA shock)0.91.01.8-1.21.11.2-1.21.2-1.2-1.31.3-1.0-0.71.0-1.01.10.81.2-0.90.1-0.90.90.3-0.0
Compulsive drug intake1.41.53.31.2-1.1-1.21.2-1.21.21.2-1.21.70.8-1.81.3-1.1-0.9-1.40.7-0.51.8-1.8-0.4-0.1
One hour access (shock baseline)0.50.51.2-0.70.60.7-0.70.7-0.7-0.80.9-1.0-0.21.1-0.90.80.40.9-0.3-0.4-1.11.10.1-0.2
Social response proportion0.80.81.7-1.00.71.1-1.01.1-1.1-1.01.3-1.1-0.41.1-1.31.10.50.9-0.30.3-1.01.00.0-0.4
Social responses1.62.13.4-1.71.61.7-1.31.4-1.4-1.11.6-1.4-1.71.4-1.80.91.81.30.31.5-1.51.51.51.0
Social time0.10.21.5-0.40.30.3-0.10.0-0.00.10.30.1-0.3-0.0-0.5-0.10.6-0.21.20.30.1-0.10.60.5
Soleus weight0.20.71.7-1.01.11.0-1.31.3-1.3-0.30.7-0.3-0.90.3-0.71.10.60.3-1.10.7-0.30.30.2-0.0
Bone: stiffness1.32.03.4-1.71.51.7-1.51.5-1.5-1.31.6-1.5-1.21.5-1.81.51.21.5-0.61.1-1.61.60.6-0.0
Tibialis anterior weight0.82.95.7-1.92.21.8-1.81.7-1.7-1.31.7-1.4-2.41.4-1.40.92.21.4-1.32.2-1.31.31.91.6
Time to tail flick, vehicle, before self-admin0.50.52.50.1-0.30.0-0.30.3-0.3-0.30.10.00.8-0.00.31.1-1.00.0-1.5-0.80.3-0.3-1.5-1.6
Time to tail flick, vehicle, after self-admin0.10.10.80.20.1-0.2-0.00.0-0.0-0.0-0.30.0-0.2-0.00.6-0.30.1-0.0-0.90.30.1-0.10.20.4
Time to tail flick, test, before self-admin0.20.21.1-0.30.50.3-0.20.2-0.2-0.10.30.1-0.7-0.1-0.1-0.40.80.10.10.90.1-0.11.01.1
Time to tail flick, test, after self-admin0.70.72.80.6-0.9-0.50.4-0.40.40.4-0.50.31.3-0.30.50.5-1.4-0.2-0.1-1.40.1-0.1-1.7-1.7
Delta time to tail flick, vehicle, before/after SA1.11.12.4-0.91.20.9-0.80.8-0.8-0.70.7-1.0-1.51.0-0.8-0.01.40.9-0.41.4-1.11.11.51.4
Delta time to tail flick, test, before/after SA0.70.63.40.2-0.6-0.1-0.10.1-0.1-0.2-0.2-0.11.00.10.21.0-1.20.1-0.9-1.1-0.10.1-1.7-1.8
Tibia length1.64.515.7-1.82.61.6-1.21.2-1.2-0.71.0-0.8-3.80.8-1.1-0.63.40.8-0.43.7-0.80.84.03.9
Ambulatory time before self-admin3.83.95.2-2.12.32.1-2.22.2-2.2-2.21.5-2.2-2.02.2-1.81.52.02.0-2.12.1-2.02.01.40.9
Ambulatory time after self-admin1.21.32.1-0.91.30.9-1.01.0-1.0-1.20.5-1.4-1.41.4-0.40.21.41.1-1.31.4-1.31.31.41.3
Bone: tissue strength0.40.40.7-0.70.50.7-0.70.7-0.7-0.60.8-0.7-0.20.7-0.70.90.20.7-0.40.2-0.80.8-0.2-0.4
Total heroin consumption1.82.14.6-1.61.41.6-1.41.2-1.2-1.11.4-1.6-1.11.6-2.11.01.51.51.01.8-1.91.91.10.5
Bone: trabecular number2.84.36.1-2.32.42.3-2.42.4-2.4-2.42.1-2.2-2.12.2-1.81.92.02.1-2.51.8-1.91.91.20.7
Bone: trabecular spacing0.50.61.70.8-1.0-0.81.0-1.01.00.8-0.50.61.0-0.60.5-0.6-0.8-0.61.3-1.00.4-0.4-0.6-0.5
Bone: trabecular thickness0.70.91.4-1.11.01.1-1.01.1-1.1-0.91.0-1.0-0.81.0-1.20.80.91.0-0.30.9-1.01.00.60.2
Bone: trabecular tissue density1.42.03.5-1.61.31.6-1.51.6-1.6-1.41.6-1.6-0.81.6-1.91.41.21.6-0.11.0-1.81.80.5-0.1
Water consumed over 24 hours0.10.10.70.3-0.1-0.30.2-0.20.2-0.4-0.2-0.1-0.00.10.5-0.4-0.10.1-0.80.30.2-0.20.10.3
Number of responses in last shaping day0.00.00.40.2-0.2-0.20.2-0.20.20.0-0.3-0.00.10.00.3-0.1-0.20.1-0.6-0.1-0.10.1-0.1-0.1