Hub : Genes

Ttc38

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr7_118811518_118814187 0.02 0.01 1.6e-03 0 0.01 0.01 0 8.1e-02 1.2e-02 2.9e-02 8.1e-02
2 LHb gene expression Ttc38 0.16 0.1 5.7e-03 0.07 0.04 0.04 0.06 7.6e-03 4.1e-02 4.2e-02 1.6e-02
3 PL gene expression Ttc38 0.06 0.03 9.5e-09 0.07 0.08 0.08 0.07 2.5e-08 3.5e-09 6.3e-09 1.8e-08
4 IL gene expression Ttc38 0.18 0.11 1.6e-03 0.08 0.1 0.05 0.09 6.4e-03 2.3e-03 2.5e-02 3.2e-03
5 Brain intron excision ratio chr7_118811518_118814187 0.04 0.03 8.1e-03 0.02 0.02 0.02 0.02 3.0e-03 2.8e-03 4.2e-03 5.7e-03
6 Adipose gene expression Ttc38 0.04 0.02 2.2e-04 0.01 0.02 0.01 0.01 1.1e-02 1.7e-03 9.7e-03 6.7e-03
7 NAcc gene expression Ttc38 0.04 0.02 2.0e-08 0.04 0.04 0.04 0.04 1.7e-07 1.9e-06 2.5e-06 2.0e-06
8 OFC gene expression Ttc38 0.31 0.15 1.1e-04 0.06 0.1 0.09 0.07 1.5e-02 2.9e-03 3.1e-03 7.6e-03
9 NAcc mRNA stability Ttc38 0.02 0.02 1.0e-03 0.02 0.02 0.02 0.02 5.7e-04 3.0e-04 3.6e-04 5.4e-04
10 pVTA gene expression Ttc38 0.08 0.05 1.0e-04 0.04 0.06 0.05 0.04 8.0e-04 2.9e-05 1.1e-04 1.6e-04
11 BLA gene expression Ttc38 0.09 0.06 8.3e-04 0.03 0.05 0.03 0.03 1.6e-02 8.9e-04 6.3e-03 8.4e-03
12 Liver gene expression Ttc38 0.08 0.05 3.9e-06 0.05 0.05 0.06 0.05 1.6e-06 6.3e-06 7.4e-07 1.6e-06
13 Brain gene expression Ttc38 0.12 0.06 8.6e-07 0.06 0.06 0.06 0.05 5.7e-06 1.4e-06 7.3e-06 2.3e-05
14 PL alternative TSS XM_017594774.3 0.05 0.03 4.5e-04 0.03 0.03 0.03 0.02 3.8e-04 2.8e-04 9.3e-04 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.11.61.20.91.21.20.71.31.11.10.81.31.30.71.3-0.4
Area under the delay curve2.93.44.62.12.12.12.01.71.92.01.91.92.11.91.31.6-0.1
BMI with tail1.75.812.3-2.2-3.2-2.5-2.8-3.5-2.1-3.0-2.8-3.0-1.8-1.7-0.4-1.2-1.5
BMI without tail0.41.23.7-1.0-1.9-1.0-1.0-1.6-0.9-1.6-1.0-1.2-0.6-0.7-0.7-0.3-0.3
Body weight1.67.110.7-2.9-3.3-2.9-2.9-3.0-3.0-3.0-2.8-2.5-2.4-2.7-2.1-2.30.2
Weight adjusted by age1.21.83.7-1.3-1.9-1.4-1.3-1.4-1.2-1.9-1.4-1.4-1.3-1.3-0.9-1.0-0.3
Bone surface0.20.40.70.80.40.80.80.50.80.60.70.60.80.70.00.6-0.2
Bone volume0.30.60.90.90.60.90.90.70.90.90.90.80.90.80.20.7-0.1
Breakpoint value in progressive ratio session0.40.52.00.1-0.3-0.2-0.3-0.80.4-0.4-0.4-0.90.10.61.10.8-1.4
Number of licking bursts0.20.41.60.20.40.50.70.80.00.30.71.10.40.0-0.7-0.01.3
Context. condit. distance diff. score1.41.73.5-1.3-0.7-1.6-1.6-0.7-1.3-0.8-1.6-1.3-1.9-1.5-0.6-1.8-0.2
Locomotion velocity, session 11.31.43.4-1.4-1.0-1.1-1.0-0.8-1.5-0.8-0.9-0.6-1.3-1.5-1.8-1.31.2
Locomotion distance, session 10.20.30.90.20.40.30.40.90.00.60.40.7-0.0-0.2-0.7-0.41.0
Locomotion velocity, session 22.93.45.6-2.2-2.0-1.9-1.8-1.9-2.4-1.6-1.7-1.2-1.7-2.0-2.2-1.71.3
Locomotion distance, session 20.20.30.60.70.20.50.40.10.70.30.40.20.70.70.80.7-0.6
Locomotion velocity, session 33.33.87.6-2.2-0.7-1.8-1.5-0.3-2.5-0.9-1.4-0.4-2.4-2.6-2.7-2.82.5
Locomotion distance, session 30.50.63.3-0.50.2-0.10.10.6-0.70.20.20.7-0.4-0.8-1.2-0.81.8
Stereotopy head waving bouts, day 31.01.22.9-0.9-0.7-1.2-1.2-0.6-1.2-0.7-1.3-0.9-1.5-1.3-1.1-1.7-0.1
Stereotopy head waving duration, day 32.73.26.2-1.5-1.4-2.0-2.0-1.2-1.8-1.5-2.2-1.7-2.3-2.1-1.5-2.5-0.5
Locomotion velocity, session 71.92.14.6-1.5-0.8-1.4-1.3-0.5-1.8-1.2-1.3-0.6-1.8-1.9-1.7-2.11.1
Locomotion distance, session 70.20.31.0-0.7-0.3-0.4-0.3-0.2-0.7-0.6-0.20.1-0.4-0.6-0.7-0.51.0
Stereotopy head waving bouts, day 71.72.04.1-1.4-0.9-1.5-1.5-0.6-1.6-0.9-1.5-0.9-1.9-1.8-1.5-2.00.7
Stereotopy head waving duration, day 70.70.92.3-0.9-0.5-1.0-1.0-0.2-1.1-0.5-1.0-0.6-1.3-1.2-0.9-1.50.4
Locomotion velocity, session 84.95.88.2-2.5-2.5-2.8-2.9-2.6-2.5-2.3-2.9-2.7-2.7-2.3-1.3-2.2-0.5
Locomotion distance, session 80.60.91.7-1.1-0.6-1.1-1.1-0.6-1.1-0.7-1.1-0.8-1.3-1.1-0.6-1.20.4
Degree of sensitization distance0.80.82.0-0.7-1.1-0.9-1.0-1.4-0.4-1.2-1.0-1.3-0.5-0.20.40.1-1.1
Degree of sensitization stereotypy0.90.91.6-1.0-0.9-1.1-1.0-0.5-1.1-0.8-1.0-0.8-1.3-1.1-0.9-1.20.3
Conditioned locomotion0.10.10.3-0.3-0.3-0.4-0.4-0.2-0.3-0.6-0.4-0.3-0.4-0.4-0.2-0.5-0.0
Cocaine response after cond. corrected0.20.21.0-0.6-0.2-0.1-0.0-0.5-0.5-0.20.10.10.1-0.3-1.00.01.0
Cocaine response after cond. not corrected0.30.42.3-0.60.10.00.1-0.0-0.50.20.30.50.1-0.4-1.4-0.21.5
Cocaine response before conditioning0.30.30.80.40.80.50.50.90.30.90.60.80.20.2-0.3-0.00.7
Saline control response0.00.10.4-0.3-0.3-0.1-0.0-0.20.1-0.20.1-0.30.10.20.10.70.0
Bone: connectivity density0.30.40.70.70.60.80.90.60.70.70.80.70.70.7-0.10.60.2
Bone: cortical apparent density1.01.42.11.41.11.31.31.51.31.11.31.21.21.11.20.9-0.2
Bone: cortical area1.52.33.9-1.6-2.0-1.7-1.7-2.0-1.3-1.8-1.7-2.0-1.3-1.2-0.5-0.7-0.7
Bone: cortical porosity0.70.82.4-0.8-1.3-0.8-0.9-1.6-0.5-0.8-0.8-1.4-0.4-0.10.50.5-0.7
Bone: cortical porosity0.91.02.6-0.9-1.6-0.9-1.0-1.6-0.6-1.2-0.9-1.5-0.5-0.20.40.3-0.8
Bone: cortical thickness0.20.31.00.0-0.7-0.2-0.2-0.60.2-0.5-0.2-0.70.10.30.80.6-1.0
Bone: cortical thickness1.72.04.7-1.0-1.9-1.4-1.5-1.9-0.7-1.7-1.6-2.2-1.0-0.60.6-0.3-1.8
Bone: cortical tissue density0.81.11.71.20.91.11.11.31.10.91.11.11.01.01.10.8-0.2
Condit. Reinf. active minus inactive responses0.50.51.40.50.50.80.80.20.70.60.90.51.00.90.71.20.1
Condit. Reinf. active-inactive response ratio1.11.21.51.11.11.21.21.11.21.11.21.01.21.21.01.1-0.1
Condit. Reinf. active responses0.91.11.80.71.11.21.20.80.71.21.31.31.20.90.11.11.0
Condit. Reinf. inactive responses0.40.52.30.00.70.50.60.6-0.00.90.71.00.40.1-0.70.11.5
Incentive salience index mean0.20.21.3-0.5-0.40.00.2-0.4-0.4-0.20.30.20.3-0.0-0.50.51.1
Condit. Reinf. lever presses1.11.63.5-1.7-1.4-1.0-0.8-1.1-1.6-1.3-0.6-0.4-0.9-1.3-1.7-0.71.9
Condit. Reinf. active minus inactive responses0.30.41.4-0.4-0.9-0.5-0.6-1.2-0.2-0.6-0.6-1.0-0.20.1-0.00.4-0.7
Condit. Reinf. active-inactive response ratio0.10.10.2-0.1-0.4-0.1-0.0-0.50.1-0.2-0.0-0.30.10.2-0.10.4-0.3
Condit. Reinf. active responses1.21.74.1-1.1-1.8-1.4-1.4-2.0-1.0-1.6-1.5-1.9-1.0-0.6-0.4-0.3-1.0
Condit. Reinf. inactive responses2.33.04.8-1.6-2.1-1.9-2.0-2.2-1.6-2.0-2.0-2.1-1.6-1.4-0.8-1.2-0.8
Condit. Reinf. lever presses0.71.01.6-0.9-1.1-1.1-1.1-1.3-0.9-1.0-1.2-1.1-0.9-0.8-0.8-0.8-0.4
Condit. Reinf. lever reinforcers received0.81.13.0-0.8-1.5-1.0-1.1-1.7-0.7-1.2-1.1-1.5-0.7-0.4-0.3-0.0-0.9
Conditioned reinforcement - actives0.00.00.1-0.4-0.0-0.2-0.1-0.2-0.10.1-0.0-0.1-0.10.1-0.20.30.3
Conditioned reinforcement - inactives0.10.20.5-0.6-0.5-0.5-0.5-0.6-0.2-0.5-0.4-0.7-0.4-0.00.10.2-0.1
Conditioned locomotion1.21.63.0-1.7-1.1-1.3-1.2-1.2-1.6-1.0-1.0-0.8-1.1-1.4-1.7-1.01.2
Patch foraging indifference point 0 sec0.10.20.90.3-0.20.50.5-0.30.40.20.50.20.80.60.11.00.0
Patch foraging indifference point AUC0.20.30.50.60.50.60.60.50.40.60.60.70.60.50.40.50.3
Delay disc. indifference point, 0s delay0.00.00.0-0.00.1-0.0-0.1-0.2-0.1-0.2-0.1-0.10.1-0.1-0.0-0.1-0.1
Delay disc. indifference point, 16s delay3.63.95.52.32.12.32.21.92.22.02.22.02.22.01.41.7-0.3
Delay disc. indifference point, 2s delay0.60.71.11.00.70.90.90.61.00.40.80.71.01.01.01.0-0.4
Delay disc. indifference point, 24s delay0.20.20.90.4-0.10.30.1-0.50.4-0.00.1-0.20.60.60.90.8-0.7
Delay disc. indifference point, 4s delay4.54.77.32.72.62.52.32.12.42.42.22.22.42.21.51.6-0.6
Delay disc. indifference point, 8s delay2.83.35.22.12.32.01.91.71.92.21.81.81.91.81.31.4-0.3
Indifference point function ln k1.83.25.1-2.3-1.8-2.0-1.9-1.7-2.0-1.8-1.8-1.7-1.9-1.9-1.8-1.60.6
Indifference point function log k1.83.25.1-2.3-1.8-2.0-1.9-1.7-2.0-1.8-1.8-1.7-1.9-1.9-1.8-1.60.6
Patch foraging total patch changes 0 sec0.20.30.80.50.20.70.70.10.50.50.70.50.90.70.10.90.1
Patch foraging total patch changes 12 sec0.00.00.00.1-0.20.0-0.0-0.1-0.0-0.2-0.1-0.00.00.10.00.0-0.1
Patch foraging total patch changes 18 sec0.40.61.00.70.30.91.00.70.60.71.01.00.90.7-0.10.80.7
Patch foraging total patch changes 24 sec0.10.10.40.00.40.20.20.4-0.10.40.20.50.1-0.2-0.3-0.20.7
Patch foraging total patch changes 6 sec0.71.02.11.20.61.21.10.51.10.81.11.01.41.10.71.2-0.2
Patch foraging time to switch 0 sec0.10.31.10.90.50.30.20.60.60.00.00.00.00.40.8-0.1-1.0
Patch foraging water rate 0 sec0.20.41.4-0.8-1.1-0.7-0.7-1.2-0.6-0.7-0.6-0.8-0.3-0.4-0.40.0-0.0
Patch foraging water rate 12 sec0.20.51.8-1.0-0.7-0.4-0.2-0.7-0.8-0.7-0.1-0.0-0.1-0.5-1.20.11.4
Patch foraging water rate 18 sec0.10.20.4-0.5-0.5-0.1-0.0-0.6-0.3-0.30.1-0.10.2-0.1-0.60.40.7
Patch foraging water rate 24 sec0.30.41.2-0.8-0.8-0.7-0.7-1.1-0.5-0.7-0.6-0.9-0.4-0.3-0.10.1-0.2
Patch foraging water rate 6 sec0.20.32.2-0.4-0.00.20.40.4-0.30.30.50.60.1-0.1-0.80.11.5
Seeking ratio, delayed vs. immediate footshock1.31.52.21.41.51.41.31.11.41.21.31.11.41.40.91.2-0.3
Distance traveled before self-admin0.30.41.8-0.70.1-0.3-0.10.3-0.60.2-0.00.3-0.5-0.6-1.1-0.51.4
Distance traveled after self-admin0.40.51.2-0.8-1.0-0.7-0.7-0.8-0.6-1.1-0.6-0.8-0.6-0.4-0.3-0.1-0.0
Extensor digitorum longus weight0.41.51.9-1.4-1.2-1.3-1.3-1.1-1.3-1.4-1.3-1.1-1.3-1.4-1.3-1.30.2
Bone: elastic displacement0.20.30.7-0.7-0.7-0.5-0.4-0.6-0.7-0.8-0.3-0.3-0.3-0.5-0.4-0.10.7
Bone: elastic work2.93.75.9-1.9-2.4-2.2-2.2-2.3-1.8-2.3-2.2-2.4-1.9-1.6-0.6-1.2-0.8
Bone: endosteal estimation2.14.66.0-2.3-2.2-2.4-2.4-2.2-2.3-2.0-2.4-2.2-2.3-2.2-1.7-2.1-0.0
Bone: endosteal perimeter2.96.18.1-2.8-2.8-2.8-2.7-2.6-2.7-2.6-2.6-2.5-2.6-2.6-1.9-2.10.3
Epididymis fat weight0.41.33.5-0.9-1.7-1.0-1.1-1.8-0.7-1.9-1.1-1.5-0.5-0.30.50.2-0.9
Delta time in closed arm before/after self-admin0.30.31.20.4-0.30.20.1-0.30.5-0.60.1-0.30.40.61.10.8-0.8
Delta time in open arm before/after self-admin1.21.24.3-0.90.2-0.5-0.30.8-1.0-0.1-0.20.6-1.1-1.3-2.1-1.62.0
Diff in mean of infusions in LGA sessions0.60.82.4-0.7-1.1-0.7-0.8-1.5-0.2-1.0-0.7-1.4-0.20.10.80.7-1.1
Delay discount exponential model param3.23.54.7-2.2-2.1-2.1-2.0-1.7-1.9-2.1-2.0-1.9-2.1-1.9-1.3-1.60.1
Extinction: sum of active levers before priming0.40.51.60.3-0.10.1-0.1-0.90.5-0.5-0.1-0.60.50.91.11.0-1.3
Active lever presses in extinction session 60.80.82.7-0.9-0.8-0.9-1.0-1.6-0.8-1.2-1.0-1.2-0.5-0.6-0.2-0.2-0.7
Bone: final force0.81.33.2-0.6-1.5-1.1-1.2-1.7-0.4-1.1-1.3-1.8-0.7-0.30.5-0.1-1.8
Bone: final moment1.11.74.3-0.6-1.7-1.2-1.4-1.9-0.4-1.3-1.5-2.0-0.8-0.40.6-0.1-2.1
Food consumed during 24 hour testing period3.95.39.5-2.5-3.1-2.6-2.5-2.7-2.3-2.6-2.5-2.7-2.3-2.1-1.2-1.5-0.4
Glucose0.10.10.8-0.1-0.10.10.1-0.30.2-0.10.2-0.20.30.40.60.90.0
Heart weight1.52.44.0-1.1-1.7-1.6-1.8-1.9-1.1-2.0-1.9-1.9-1.4-1.1-0.4-1.2-1.4
Delay discount hyperbolic model param3.33.75.0-2.2-2.2-2.2-2.1-1.7-2.0-2.2-2.0-2.0-2.1-2.0-1.3-1.60.1
Intermittent access intake day 1-15 change0.51.02.9-1.2-1.7-1.0-0.9-1.5-0.7-1.2-0.8-1.3-0.7-0.3-0.30.4-0.1
Intermittent access intake escalation0.20.41.5-0.9-1.2-0.6-0.5-0.8-0.5-0.7-0.4-0.8-0.5-0.2-0.50.30.3
Intermittent access intake escalation 20.40.51.7-0.2-1.3-0.1-0.1-0.90.3-0.8-0.0-0.80.10.70.61.3-0.6
Intermitt. access day 1 inactive lever presses0.10.41.4-0.0-0.7-0.4-0.5-0.60.1-0.6-0.5-0.9-0.20.21.10.4-1.2
Intermitt. access day 15 inactive lever presses0.71.53.9-1.3-1.8-1.2-1.2-2.0-0.8-1.5-1.1-1.7-0.6-0.40.20.3-0.8
Intermitt. access escalation Index0.20.20.40.40.30.50.60.40.70.20.60.40.60.60.40.6-0.1
Intermittent access day 1 total infusions1.62.54.9-2.2-0.7-1.7-1.5-1.0-2.1-0.9-1.3-0.7-1.7-1.9-2.0-1.71.8
Intermittent access day 15 total infusions1.52.25.2-2.3-1.2-1.6-1.3-1.0-1.8-1.1-1.0-0.9-1.6-1.5-1.9-1.01.8
Intermittent access terminal intake (last 3 days)2.53.37.1-2.7-1.9-2.0-1.8-1.8-2.1-1.7-1.5-1.5-1.8-1.7-1.9-1.01.4
Intermittent access total infusions2.22.65.6-2.4-1.4-1.8-1.6-1.4-2.0-1.3-1.4-1.2-1.8-1.7-1.7-1.21.4
Intermittent access day 1 locomotion0.70.94.0-1.30.2-0.6-0.4-0.1-1.30.2-0.20.3-0.7-1.1-1.6-0.92.0
Intermittent access day 15 total locomotion1.83.36.8-2.6-1.2-2.0-1.8-1.4-2.4-1.1-1.6-1.1-1.9-2.1-2.2-1.71.7
Intermittent access total locomotion2.32.85.4-2.3-1.2-1.9-1.7-1.3-2.1-1.2-1.5-1.2-1.9-1.8-1.8-1.51.4
Intermittent access standard deviation0.91.93.7-1.6-1.9-1.6-1.6-1.8-1.3-1.4-1.5-1.8-1.3-0.9-0.5-0.4-0.3
Left kidney weight11.051.467.9-7.5-7.7-8.1-8.2-7.3-7.4-7.8-8.2-7.6-7.7-7.2-4.5-6.6-1.0
Right kidney weight10.748.766.5-6.9-7.8-7.9-8.1-7.4-6.9-8.0-8.2-7.8-7.3-6.6-3.6-6.1-2.0
Cocaine induced anxiety0.50.72.2-0.1-1.0-0.5-0.7-1.3-0.0-0.6-0.8-1.2-0.20.20.80.4-1.5
Post-drug Anxiety1.11.13.51.00.10.70.5-0.41.20.70.4-0.31.11.41.91.6-1.7
Baseline Anxiety0.70.81.70.41.20.81.01.00.51.31.01.20.80.5-0.10.51.0
Tail length0.31.15.9-0.10.40.71.01.1-0.10.81.21.40.5-0.0-1.40.22.4
Length with tail0.52.25.3-1.8-1.4-1.3-1.1-0.8-1.9-1.2-0.9-0.5-1.4-1.8-2.3-1.41.9
Length without tail1.13.77.3-2.0-2.3-2.1-2.2-2.7-1.9-2.4-2.1-2.2-1.5-1.5-0.6-1.0-0.6
Times rat made contact with spout0.91.02.7-1.0-0.8-0.9-0.7-0.4-1.2-0.6-0.7-0.3-1.1-1.3-1.6-1.41.0
Lifetime Intake2.32.75.5-2.3-1.4-1.9-1.7-1.3-2.0-1.4-1.5-1.3-1.9-1.7-1.8-1.31.4
Liver weight, left1.83.04.6-2.1-1.3-1.8-1.7-1.3-2.1-1.6-1.6-1.1-1.8-2.0-2.0-1.81.2
Liver weight, right1.62.76.6-2.0-0.8-1.4-1.2-0.4-2.1-0.8-1.0-0.2-1.7-2.2-2.6-2.02.3
Locomotor activity3.25.17.6-2.7-2.2-2.4-2.2-2.0-2.8-2.3-2.1-1.6-2.3-2.6-2.6-2.21.2
Locomotor testing distance0.30.51.7-0.9-0.5-0.6-0.5-0.5-0.9-0.7-0.5-0.3-0.6-0.9-1.3-0.80.8
Locomotor testing rearing0.91.84.3-1.5-1.0-1.3-1.2-0.7-1.5-1.0-1.2-0.8-1.6-1.6-2.1-1.70.9
Locomotion in novel chamber1.11.45.8-0.50.60.10.41.2-0.80.70.41.3-0.4-1.2-2.4-1.42.4
Locomotion in novel chamber post-restriction0.10.20.80.50.90.40.30.40.40.30.30.40.40.20.3-0.0-0.2
Fecal boli incidents, locomotor time 10.10.20.3-0.40.0-0.4-0.4-0.4-0.6-0.2-0.4-0.2-0.4-0.5-0.5-0.50.3
Change in fecal boli incidents, locomotor task0.10.10.3-0.2-0.3-0.00.10.4-0.20.10.10.2-0.2-0.3-0.6-0.30.5
Time >=10cm from walls, locomotor time 10.20.20.6-0.1-0.3-0.4-0.5-0.4-0.3-0.4-0.7-0.5-0.5-0.5-0.1-0.7-0.7
Bouts of movement, locomotor time 10.20.31.1-0.5-0.4-0.6-0.6-1.0-0.4-0.3-0.6-0.8-0.3-0.10.00.1-0.4
Total resting periods, locomotor time 10.20.31.0-0.1-0.3-0.3-0.4-1.00.0-0.3-0.4-0.80.10.30.50.4-1.0
Rest time, locomotor task time 10.60.71.1-0.8-0.6-0.9-0.9-1.0-1.0-0.7-0.9-0.7-0.8-0.9-1.0-0.90.1
Distance moved, locomotor task time 10.00.00.1-0.10.3-0.1-0.1-0.0-0.10.1-0.1-0.1-0.1-0.10.1-0.1-0.0
Vertical activity count, locomotor time 10.10.30.70.6-0.00.40.40.10.60.10.3-0.00.50.60.90.7-0.7
Time >=10cm from walls, locomotor time 20.30.51.5-0.1-1.0-0.2-0.3-0.90.1-1.2-0.4-0.80.10.20.80.5-1.1
Bouts of movement, locomotor time 20.81.34.41.40.91.00.80.61.30.90.70.41.11.32.11.1-1.3
Total resting periods, locomotor time 20.81.43.91.51.01.10.90.61.41.10.80.51.21.42.01.2-1.2
Rest time, locomotor task time 21.92.45.21.01.91.51.71.80.62.21.72.31.20.6-1.20.32.1
Distance moved, locomotor task time 22.22.64.3-1.6-1.7-1.9-1.9-1.7-1.4-2.1-1.9-2.0-1.7-1.3-0.2-1.1-0.8
Vertical activity count, locomotor time 21.92.65.1-1.4-2.3-1.7-1.8-1.8-1.1-2.2-1.9-2.2-1.5-1.10.3-0.7-1.4
Light reinforcement 10.81.94.3-1.5-0.9-1.3-1.2-0.7-1.6-1.1-1.2-0.5-1.4-1.8-2.1-1.81.1
Light reinforcement 22.74.25.8-2.4-2.4-2.2-2.2-2.4-2.3-2.4-2.1-2.0-1.9-2.0-1.5-1.50.3
Bone: marrow area2.04.45.8-2.3-2.1-2.4-2.4-2.2-2.2-1.9-2.4-2.2-2.3-2.2-1.6-2.0-0.1
Bone: maximum diameter5.39.914.5-3.4-3.8-3.5-3.5-3.7-3.2-3.4-3.5-3.6-3.1-2.8-1.8-2.2-0.5
Bone: maximum force1.11.95.0-0.7-1.6-1.3-1.5-1.9-0.5-1.3-1.7-2.2-1.0-0.50.7-0.3-2.2
Bone: maximum moment1.42.46.2-0.8-1.8-1.5-1.7-2.1-0.6-1.5-1.9-2.4-1.1-0.50.7-0.4-2.5
Mean time between licks in bursts0.30.71.60.80.91.01.11.30.70.51.11.20.80.4-0.10.20.7
Mean num. licks in bursts0.81.32.5-1.1-1.4-1.3-1.4-1.4-0.9-1.1-1.4-1.6-1.2-0.8-0.2-0.7-0.8
Cd content in liver0.10.20.3-0.2-0.3-0.4-0.4-0.2-0.2-0.4-0.5-0.5-0.5-0.4-0.3-0.5-0.4
Co content in liver0.10.10.3-0.3-0.1-0.1-0.00.0-0.3-0.30.00.1-0.2-0.3-0.6-0.20.5
Cu content in liver7.79.112.03.43.43.43.22.63.43.23.12.83.53.22.52.9-0.7
Fe content in liver0.30.41.60.1-0.7-0.3-0.4-0.90.1-0.7-0.5-0.9-0.00.30.70.4-1.3
K content in liver0.10.10.40.10.40.10.1-0.10.10.60.10.00.30.20.60.4-0.1
Mg content in liver0.40.41.00.60.60.50.40.00.70.80.40.20.70.71.00.8-0.7
Mn content in liver1.01.12.0-1.4-0.8-1.0-0.9-0.5-1.4-0.7-0.8-0.4-1.1-1.3-1.1-1.11.4
Na content in liver2.12.34.21.71.81.61.51.41.62.01.41.31.51.51.51.2-0.5
Rb content in liver1.11.34.61.20.30.70.5-0.31.40.20.4-0.31.11.42.01.4-2.1
Se content in liver0.10.10.4-0.00.70.30.30.30.00.60.40.50.20.0-0.40.10.7
Sr content in liver0.60.51.30.30.90.50.61.10.10.80.61.00.2-0.0-0.8-0.31.1
Zn content in liver0.30.31.0-0.11.0-0.1-0.10.6-0.30.7-0.10.3-0.5-0.5-0.8-0.90.5
Bone: minimum diameter1.62.94.6-2.1-1.8-1.9-1.8-1.6-2.0-1.5-1.7-1.5-1.8-1.8-1.7-1.50.7
Time in familiar zone, hab. session 11.01.01.3-1.0-0.9-1.1-1.1-1.1-1.0-1.0-1.1-1.0-1.0-1.1-0.9-1.0-0.0
Time in novel zone, hab. session 10.10.10.30.40.00.30.30.30.50.20.3-0.00.20.40.60.5-0.5
Total zone transitions, hab. session 11.72.44.61.71.91.61.61.71.62.11.61.51.41.41.21.1-0.1
Total locomotion distance, hab. session 10.10.20.5-0.10.4-0.00.00.7-0.20.40.10.4-0.3-0.5-0.3-0.60.7
Locomotion velocity, hab. session 10.20.20.8-0.20.3-0.00.00.7-0.30.30.10.5-0.4-0.5-0.5-0.70.9
Time in familiar zone, hab. session 20.20.31.4-0.6-0.0-0.2-0.1-0.1-0.6-0.10.00.2-0.2-0.5-1.0-0.31.2
Time in novel zone, hab. session 20.50.51.30.90.30.60.60.61.00.40.50.20.60.91.10.7-1.0
Total zone transitions, hab. session 20.20.21.2-0.1-0.4-0.3-0.5-0.70.1-0.3-0.5-0.8-0.10.00.50.1-1.1
Total locomotion distance, hab. session 20.10.10.2-0.3-0.4-0.4-0.4-0.3-0.3-0.4-0.4-0.4-0.3-0.30.2-0.2-0.2
Locomotion velocity, hab. session 20.10.10.1-0.3-0.4-0.3-0.3-0.3-0.2-0.4-0.3-0.3-0.3-0.20.1-0.2-0.1
Novel to familiar place preference ratio0.10.10.80.50.10.30.40.90.40.20.30.4-0.10.0-0.3-0.3-0.0
Novelty place preference0.10.10.60.1-0.1-0.00.00.7-0.0-0.1-0.10.2-0.5-0.4-0.7-0.80.2
Time in novel zone, NPP test0.20.20.70.2-0.2-0.00.10.90.0-0.1-0.00.2-0.6-0.4-0.7-0.90.2
Total zone transitions, NPP test0.91.31.71.31.01.31.21.21.31.11.21.11.11.21.11.0-0.2
Total locomotion distance, NPP test0.10.10.30.40.40.40.40.60.30.40.40.50.30.30.40.20.2
Locomotion velocity, NPP test0.20.20.50.40.60.50.50.60.30.60.50.70.40.40.30.30.5
Intraocular pressure0.60.93.3-1.20.3-0.6-0.5-0.3-1.3-0.1-0.30.2-0.6-1.1-1.6-0.91.8
Delta distance traveled before/after self-admin0.60.71.7-0.7-1.0-0.8-0.8-0.9-0.7-1.3-0.9-0.9-0.7-0.7-0.5-0.6-0.3
Delta ambulatory time before/after self-admin0.30.41.2-0.5-0.8-0.6-0.6-0.9-0.5-1.1-0.7-0.7-0.4-0.5-0.2-0.3-0.4
Parametrial fat weight0.51.13.00.61.21.01.11.30.31.31.21.70.80.2-0.70.11.7
Pavlov. Cond. lever latency0.70.92.11.41.10.80.61.01.21.10.40.40.60.91.30.2-1.4
Pavlov. Cond. magazine entry latency0.40.52.30.3-0.50.60.6-0.40.6-0.30.70.11.00.90.51.50.0
Pavlov. Cond. change in total contacts0.30.41.8-0.2-0.60.10.2-1.10.1-0.60.3-0.40.80.60.41.4-0.2
Pavlov. Cond. index score0.20.21.0-0.3-0.70.10.1-0.8-0.1-0.60.3-0.20.50.3-0.01.00.4
Pavlov. Cond. latency score0.20.30.8-0.6-0.9-0.2-0.1-0.9-0.3-0.70.0-0.30.10.0-0.30.70.5
Pavlov. Cond. lever contacts0.70.82.4-1.3-1.0-0.6-0.5-1.1-1.1-1.1-0.3-0.3-0.3-0.7-1.20.11.5
Pavlov. Cond. magazine entry number0.40.52.4-0.20.3-0.6-0.70.4-0.50.1-0.8-0.3-1.0-0.9-0.5-1.5-0.2
Pavlov. Cond. intertrial magazine entries1.21.42.11.11.21.31.30.91.21.31.41.21.41.31.01.30.1
Pavlov. Cond. lever-magazine prob. diff.0.20.21.1-0.2-0.50.20.3-0.60.0-0.40.40.00.60.40.01.10.5
Pavlov. Cond. response bias0.30.41.2-0.6-0.80.00.1-1.0-0.3-0.80.3-0.10.60.2-0.41.10.9
Pavlov. Cond. lever latency0.30.51.10.50.90.70.81.00.40.70.81.00.50.30.20.20.7
Pavlov. Cond. magazine entry latency1.92.35.31.80.71.21.00.21.91.00.90.11.62.02.31.9-2.2
Pavlov. Cond. change in total contacts0.40.73.80.4-0.6-0.2-0.3-1.00.5-0.3-0.4-1.10.20.71.10.8-2.0
Pavlov. Cond. index score0.30.42.00.6-0.10.20.1-0.50.70.2-0.0-0.50.50.80.90.8-1.4
Pavlov. Cond. latency score0.30.52.40.5-0.20.1-0.0-0.70.60.0-0.1-0.60.40.81.00.8-1.6
Pavlov. Cond. lever contacts0.30.31.0-0.3-0.9-0.5-0.6-1.0-0.2-0.6-0.6-0.9-0.20.00.10.2-0.9
Pavlov. Cond. magazine entry number0.50.62.3-1.0-0.2-0.5-0.3-0.1-1.0-0.6-0.20.2-0.6-1.0-1.3-0.81.5
Pavlov. Cond. intertrial magazine entries0.40.61.6-0.5-0.8-0.7-0.9-1.3-0.4-0.9-0.9-1.2-0.4-0.20.50.1-1.0
Pavlov. Cond. lever-magazine prob. diff.0.30.31.50.6-0.00.30.1-0.30.70.30.1-0.30.50.80.90.7-1.2
Pavlov. Cond. response bias0.20.21.10.4-0.30.10.0-0.50.5-0.0-0.0-0.40.40.70.60.7-1.1
Time in closed arm before self-admin1.51.93.21.21.31.51.51.01.41.61.61.21.61.51.01.80.3
Time in closed arm after self-admin0.30.40.70.40.60.70.80.70.50.60.80.70.60.50.30.60.6
Time in open arm before self-admin0.10.10.80.00.4-0.1-0.20.4-0.30.4-0.20.3-0.3-0.5-0.4-0.90.2
Time in open arm after self-admin0.20.21.0-0.30.4-0.3-0.40.3-0.5-0.1-0.40.1-0.6-0.6-0.6-1.00.4
Bone: periosteal estimation2.55.26.8-2.5-2.6-2.6-2.6-2.6-2.3-2.3-2.6-2.6-2.3-2.2-1.4-1.8-0.4
Bone: periosteal perimeter4.17.010.1-3.2-3.0-2.9-2.8-2.8-3.0-2.8-2.7-2.5-2.6-2.7-2.3-2.10.7
Bone: post-yield work0.50.82.41.20.70.80.60.31.20.50.50.20.91.01.10.7-1.5
Progressive ratio test 1 active lever presses0.60.83.4-1.20.3-0.6-0.4-0.2-1.10.1-0.20.3-0.5-1.0-1.5-0.81.9
Progressive ratio test 1 breakpoint0.60.73.5-1.10.4-0.4-0.2-0.1-1.00.2-0.10.4-0.4-0.9-1.5-0.71.9
Progressive ratio test 1 inactive lever presses0.71.01.9-1.4-0.4-1.1-1.0-0.5-1.3-0.6-0.9-0.4-1.1-1.3-1.0-1.21.0
Progressive ratio test 2 active lever presses0.20.30.6-0.7-0.4-0.6-0.7-0.7-0.4-0.5-0.6-0.7-0.4-0.10.50.1-0.2
Progressive ratio test 2 breakpoint0.20.20.5-0.7-0.3-0.6-0.6-0.7-0.5-0.5-0.5-0.6-0.4-0.20.40.0-0.0
Progressive ratio test 2 inactive lever presses0.20.30.8-0.9-0.4-0.7-0.7-0.7-0.6-0.5-0.6-0.7-0.5-0.30.40.10.2
Incentive Sensitization - Responses0.40.51.9-0.3-0.7-0.4-0.6-0.90.0-0.7-0.5-1.0-0.10.41.40.6-1.1
Incentive Sensitization - Breakpoint0.50.61.6-0.4-0.8-0.6-0.7-1.1-0.1-0.9-0.7-1.1-0.30.21.30.5-1.2
Sum of active levers in priming session hrs 5-60.20.10.80.30.00.0-0.0-0.30.4-0.1-0.1-0.40.10.50.60.5-0.9
Progressive ratio0.20.30.50.50.70.60.60.40.50.50.60.50.50.60.10.60.2
Food seeking constrained by brief footshock0.40.51.3-0.6-0.7-0.8-0.8-1.1-0.5-1.0-0.9-1.0-0.5-0.50.1-0.3-0.7
Seeking ratio, punishment vs. effort0.81.13.1-0.5-1.3-0.9-1.1-1.5-0.2-1.3-1.2-1.5-0.5-0.31.1-0.0-1.7
Retroperitoneal fat weight1.87.714.2-2.9-3.5-3.0-3.2-3.8-2.8-3.5-3.1-3.2-2.3-2.2-1.0-1.6-0.7
Reaction time number correct0.20.30.80.50.80.60.60.70.30.90.60.80.40.2-0.10.10.6
Reaction time mean minus median0.20.50.80.60.80.70.80.80.40.90.80.80.60.50.20.50.6
Reaction time mean minus median AUC0.10.30.80.20.90.30.30.7-0.20.90.30.7-0.0-0.2-0.5-0.60.9
Reaction time num false alarms0.40.52.8-0.70.2-0.2-0.00.3-0.70.30.10.4-0.5-0.7-1.4-0.61.7
Reaction time num false alarms AUC0.50.83.9-0.90.1-0.4-0.20.4-0.90.3-0.00.4-0.7-0.9-1.5-0.82.0
Reaction time trials correct on left0.20.30.80.50.80.60.60.70.30.90.60.80.40.2-0.10.10.6
Reaction time trials on left0.20.30.80.50.80.60.60.80.30.90.70.80.50.3-0.10.20.6
Reaction time mean2.13.35.22.11.81.91.71.32.11.71.61.21.92.12.32.0-1.1
Reaction time mean AUC2.13.44.72.22.01.91.81.52.11.91.71.31.82.12.11.8-1.0
Median of all reaction times2.73.97.12.31.81.91.81.32.41.71.71.02.12.42.72.2-1.6
Reaction time omissions0.81.21.71.31.11.21.21.11.21.01.11.11.21.10.90.9-0.2
Reaction time false alarm rate0.50.61.8-1.1-0.4-0.7-0.5-0.1-1.0-0.2-0.4-0.1-0.9-0.9-1.2-0.71.4
Reaction time premature initiation rate1.01.36.20.3-1.0-0.4-0.7-1.40.4-0.8-0.8-1.6-0.00.71.90.9-2.5
Reaction time premature initiations0.40.83.80.6-0.50.0-0.2-0.70.6-0.1-0.3-0.90.30.81.70.9-1.9
Std. dev. reaction times0.71.31.61.21.31.31.31.21.11.21.31.21.11.21.01.10.2
Reaction time trials completed0.20.30.80.50.80.60.60.80.30.90.70.80.50.3-0.10.20.6
Reaction time trials AUC0.10.20.40.30.50.40.40.50.10.60.40.50.30.1-0.20.10.5
Run reversals in cocaine runway, females0.30.31.00.00.30.40.60.70.10.40.70.80.4-0.1-0.70.11.0
Run reversals in cocaine runway, males1.61.63.8-1.5-0.6-1.1-0.9-0.3-1.6-0.6-0.8-0.3-1.4-1.6-2.0-1.61.7
Latency to leave start box in cocaine runway1.51.72.4-1.5-1.3-1.5-1.5-1.3-1.4-1.3-1.5-1.4-1.4-1.4-0.6-1.2-0.1
Latency to leave start box in cocaine runway, F1.31.52.0-1.3-1.2-1.4-1.4-1.3-1.2-1.4-1.4-1.3-1.3-1.3-0.7-1.1-0.2
Latency to leave start box in cocaine runway, M0.40.40.6-0.8-0.6-0.7-0.7-0.6-0.7-0.5-0.7-0.7-0.7-0.6-0.2-0.40.1
Std. dev. time between licks in bursts0.30.41.20.6-0.20.40.3-0.20.7-0.60.2-0.10.70.70.90.8-1.1
Total sessions with >9 infusions2.83.44.8-2.1-1.5-2.1-2.0-1.4-2.2-1.5-1.9-1.5-2.2-2.1-2.0-2.00.8
Short access day 1 total inactive lever presses2.43.15.9-2.0-2.2-1.9-1.9-2.4-1.8-2.1-1.9-2.0-1.5-1.4-1.0-0.9-0.2
Short access day 10 total inactive lever presses0.30.71.8-0.8-1.3-0.9-0.9-1.1-0.8-0.8-0.9-1.0-0.7-0.6-0.0-0.4-0.3
Short access day 1 total infusions1.41.83.1-1.8-1.2-1.5-1.3-1.0-1.6-0.8-1.2-1.0-1.6-1.5-1.7-1.30.9
Short access day 10 total infusions1.92.44.7-2.2-1.3-1.7-1.5-1.5-2.0-1.4-1.3-1.1-1.5-1.6-1.7-1.21.3
Short access total infusions2.43.15.1-2.2-1.7-2.0-1.9-1.7-2.0-1.7-1.8-1.6-1.9-1.7-1.5-1.40.7
Short access day 1 locomotion0.10.20.3-0.5-0.2-0.5-0.5-0.3-0.5-0.1-0.4-0.4-0.6-0.4-0.5-0.40.2
Short access day 10 total locomotion0.91.66.4-1.30.1-0.6-0.30.4-1.50.1-0.20.7-0.9-1.5-2.4-1.62.5
Short access total locomotion0.80.92.2-1.3-0.5-0.9-0.8-0.5-1.2-0.6-0.7-0.3-1.0-1.2-1.5-1.01.2
One hour access (0.3 mA shock)1.11.32.3-1.5-0.9-1.4-1.3-1.0-1.3-1.0-1.2-1.0-1.4-1.2-0.8-0.90.5
Compulsive drug intake0.20.21.50.5-0.40.0-0.1-0.10.4-0.4-0.2-0.40.00.30.90.1-1.2
One hour access (shock baseline)1.11.63.8-1.9-0.8-1.4-1.3-1.0-1.6-1.0-1.1-0.9-1.4-1.4-1.5-0.91.3
Social response proportion1.51.73.3-1.3-1.8-1.4-1.3-1.3-1.2-1.8-1.4-1.5-1.3-1.2-0.9-1.0-0.3
Social responses1.92.54.0-1.8-1.6-1.6-1.4-1.1-1.9-1.6-1.4-1.0-1.6-1.9-2.0-1.71.0
Social time0.30.42.5-0.10.00.50.60.5-0.10.20.70.90.4-0.1-0.90.21.6
Soleus weight0.20.72.2-0.6-1.1-0.8-0.9-1.5-0.5-1.0-0.9-1.2-0.4-0.20.20.1-0.9
Bone: stiffness0.91.49.01.0-0.10.2-0.1-0.61.20.2-0.3-1.10.51.12.01.0-3.0
Tibialis anterior weight0.10.40.90.90.90.60.50.60.80.80.40.40.50.50.40.2-0.7
Time to tail flick, vehicle, before self-admin0.20.20.70.00.90.10.20.5-0.00.70.20.50.1-0.2-0.5-0.40.4
Time to tail flick, vehicle, after self-admin0.00.10.3-0.3-0.1-0.10.0-0.2-0.20.20.10.00.0-0.1-0.50.20.5
Time to tail flick, test, before self-admin1.81.83.0-1.5-1.5-1.4-1.2-0.8-1.5-1.4-1.2-0.9-1.5-1.6-1.7-1.50.8
Time to tail flick, test, after self-admin0.40.40.90.0-0.70.00.0-0.70.4-0.80.0-0.60.30.60.91.0-0.9
Delta time to tail flick, vehicle, before/after SA0.80.71.7-0.6-1.3-0.8-0.9-1.3-0.6-1.1-1.0-1.2-0.6-0.40.2-0.2-0.8
Delta time to tail flick, test, before/after SA2.32.45.01.61.01.51.40.61.91.11.30.61.82.02.22.2-1.2
Tibia length0.10.21.1-0.6-0.7-0.4-0.4-1.0-0.4-0.4-0.3-0.5-0.0-0.1-0.20.40.2
Ambulatory time before self-admin0.40.63.0-0.70.2-0.3-0.10.6-0.70.30.10.5-0.6-0.7-1.4-0.71.7
Ambulatory time after self-admin0.10.10.3-0.2-0.30.10.1-0.10.1-0.50.20.00.10.1-0.10.40.3
Bone: tissue strength0.80.81.91.00.30.70.5-0.11.00.50.40.01.01.11.41.2-1.3
Total heroin consumption0.70.93.0-0.2-0.3-0.6-0.9-1.6-0.1-0.7-0.9-1.3-0.10.21.40.5-1.7
Bone: trabecular number0.61.01.70.90.91.21.31.10.91.01.31.31.10.90.00.90.7
Bone: trabecular spacing2.93.85.6-1.9-1.8-2.2-2.3-2.2-2.0-1.9-2.4-2.1-2.1-2.0-1.2-1.9-0.5
Bone: trabecular thickness0.10.20.30.30.10.40.50.50.40.20.50.40.40.40.40.50.3
Bone: trabecular tissue density1.21.82.71.61.61.31.21.31.51.71.21.01.21.51.51.1-0.7
Water consumed over 24 hours1.21.63.3-1.3-1.8-1.4-1.3-1.3-1.3-1.3-1.4-1.4-1.4-1.2-0.8-1.0-0.2
Number of responses in last shaping day0.10.10.20.40.40.30.40.40.40.40.30.30.30.20.00.1-0.2