Ttc19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	NM_001415772.1	0.08	0.14	4.5e-04	0.02	0.02	0.04	0.02	2.2e-03	3.1e-03	7.9e-05	3.0e-03
2	PL	mRNA stability	Ttc19	0.04	0.06	3.1e-03	0.02	0.01	0.02	0.02	1.2e-03	1.4e-02	1.9e-03	4.1e-03
3	Brain	mRNA stability	Ttc19	0.03	0.03	6.8e-03	0.01	0.01	0.01	0.01	2.9e-02	5.8e-02	2.5e-02	5.0e-02
4	Liver	mRNA stability	Ttc19	0.07	0.06	7.6e-07	0.04	0.04	0.05	0.05	9.4e-06	8.1e-06	5.3e-06	6.3e-06
5	Liver	gene expression	Ttc19	0.07	0.06	9.5e-07	0.03	0.04	0.02	0.03	4.2e-04	8.5e-05	9.9e-04	7.9e-04
6	Adipose	mRNA stability	Ttc19	0.05	0.04	1.6e-04	0.01	0.02	0.01	0.02	7.5e-03	1.5e-03	9.7e-03	6.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	3.1	-1.8	0.3	0.0	0.1	0.0	0.0
Area under the delay curve	2.4	3.7	4.5	-1.2	1.9	2.1	2.0	-2.1	-2.1
BMI with tail	0.8	2.7	12.2	3.5	-0.9	-1.0	-0.8	0.9	0.9
BMI without tail	0.4	2.1	2.5	-0.7	1.5	1.6	1.6	-1.5	-1.5
Body weight	0.2	0.7	1.7	1.3	-0.7	-0.7	-0.7	0.7	0.7
Weight adjusted by age	0.5	1.4	1.9	0.7	0.9	1.4	1.2	-1.4	-1.4
Bone surface	0.4	0.9	3.5	-1.9	0.7	0.6	0.6	-0.5	-0.5
Bone volume	0.5	0.9	3.5	-1.9	0.9	0.5	0.6	-0.5	-0.5
Breakpoint value in progressive ratio session	1.1	2.0	2.3	-1.5	-1.1	-1.5	-1.4	1.5	1.5
Number of licking bursts	0.8	2.4	5.8	2.4	-1.2	-1.4	-1.2	1.4	1.4
Context. condit. distance diff. score	2.0	2.4	14.3	3.8	-0.2	-0.0	0.1	-0.1	-0.1
Locomotion velocity, session 1	0.5	0.6	1.5	-1.2	0.7	0.7	0.6	-0.6	-0.6
Locomotion distance, session 1	3.4	4.4	19.2	-4.4	1.5	1.2	1.2	-1.1	-1.0
Locomotion velocity, session 2	0.7	0.9	4.6	-2.1	0.6	0.4	0.4	-0.3	-0.3
Locomotion distance, session 2	4.5	6.3	37.1	-6.1	0.8	0.3	0.2	-0.1	-0.1
Locomotion velocity, session 3	0.0	0.0	0.1	0.0	0.3	0.1	0.2	-0.1	-0.1
Locomotion distance, session 3	0.2	0.2	0.3	-0.2	-0.3	-0.6	-0.5	0.5	0.5
Stereotopy head waving bouts, day 3	1.4	1.6	2.2	-0.9	0.9	1.5	1.2	-1.5	-1.5
Stereotopy head waving duration, day 3	1.1	1.4	2.0	-0.9	0.8	1.4	1.1	-1.4	-1.4
Locomotion velocity, session 7	2.1	2.3	2.9	-0.5	-1.5	-1.7	-1.7	1.7	1.7
Locomotion distance, session 7	1.1	1.4	3.3	-1.8	-0.8	-1.1	-1.1	1.1	1.1
Stereotopy head waving bouts, day 7	7.8	9.1	10.3	-2.6	2.9	3.2	3.0	-3.2	-3.1
Stereotopy head waving duration, day 7	8.2	10.2	11.0	-2.8	3.2	3.3	3.2	-3.3	-3.3
Locomotion velocity, session 8	0.0	0.0	0.1	-0.0	-0.0	-0.2	-0.1	0.2	0.2
Locomotion distance, session 8	0.5	0.7	2.5	-1.6	0.8	0.6	0.6	-0.6	-0.6
Degree of sensitization distance	0.4	0.4	2.5	-1.6	-0.0	-0.1	-0.1	0.1	0.1
Degree of sensitization stereotypy	8.5	9.5	10.2	-2.6	3.1	3.2	3.2	-3.2	-3.2
Conditioned locomotion	0.0	0.0	0.0	-0.2	0.1	0.1	0.1	-0.2	-0.2
Cocaine response after cond. corrected	0.9	1.3	4.3	-2.1	-0.7	-0.8	-0.9	0.8	0.9
Cocaine response after cond. not corrected	0.5	0.7	1.2	-1.1	-0.8	-0.8	-0.9	0.8	0.8
Cocaine response before conditioning	0.5	0.6	3.5	1.9	-0.4	-0.2	-0.2	0.2	0.1
Saline control response	0.1	0.1	0.4	-0.7	0.0	-0.3	-0.2	0.4	0.4
Bone: connectivity density	0.7	1.1	5.9	-2.4	0.6	0.4	0.4	-0.3	-0.3
Bone: cortical apparent density	1.8	2.9	11.0	-3.3	-0.7	-1.2	-1.1	1.2	1.2
Bone: cortical area	2.5	4.1	14.4	3.8	-1.9	-1.2	-1.5	1.2	1.2
Bone: cortical porosity	7.2	7.8	36.5	6.0	-1.8	-1.4	-1.4	1.3	1.3
Bone: cortical porosity	5.9	6.5	34.0	5.8	-1.4	-0.9	-0.9	0.8	0.8
Bone: cortical thickness	6.0	9.9	24.9	5.0	-3.0	-2.6	-2.6	2.5	2.5
Bone: cortical thickness	2.7	3.3	3.7	1.6	-1.9	-1.8	-1.9	1.8	1.8
Bone: cortical tissue density	1.9	3.0	12.4	-3.5	-0.6	-1.1	-1.1	1.2	1.2
Condit. Reinf. active minus inactive responses	7.5	8.4	31.6	-5.6	2.2	2.0	1.9	-1.8	-1.8
Condit. Reinf. active-inactive response ratio	9.3	10.0	33.6	-5.8	2.5	2.3	2.2	-2.2	-2.2
Condit. Reinf. active responses	4.4	5.6	16.1	-4.0	2.0	1.9	1.8	-1.8	-1.8
Condit. Reinf. inactive responses	0.4	0.5	2.7	1.7	0.0	0.0	0.1	-0.1	-0.1
Incentive salience index mean	3.0	3.8	14.4	-3.8	1.4	1.4	1.2	-1.3	-1.3
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	-0.1	0.2	0.1	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	-0.3	-0.4	-0.4	-0.5	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.7	4.3	-2.1	0.3	0.1	0.1	-0.1	-0.1
Condit. Reinf. active responses	0.3	0.5	0.6	-0.6	-0.5	-0.8	-0.7	0.7	0.8
Condit. Reinf. inactive responses	0.6	1.0	1.9	1.4	-0.7	-1.0	-0.8	1.0	1.0
Condit. Reinf. lever presses	0.1	0.1	0.3	0.5	-0.2	-0.2	-0.2	0.2	0.2
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	-0.4	-0.5	-0.7	-0.6	0.6	0.6
Conditioned reinforcement - actives	0.0	0.2	0.4	-0.1	0.6	0.3	0.5	-0.3	-0.3
Conditioned reinforcement - inactives	0.8	2.3	3.0	-0.4	1.7	1.6	1.7	-1.6	-1.6
Conditioned locomotion	1.7	2.6	3.9	-1.4	2.0	1.5	1.7	-1.5	-1.5
Patch foraging indifference point 0 sec	2.3	6.6	8.1	-2.8	2.7	2.5	2.6	-2.4	-2.4
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.2	0.3	0.3
Delay disc. indifference point, 0s delay	1.4	1.6	2.1	-0.5	1.1	1.5	1.3	-1.4	-1.4
Delay disc. indifference point, 16s delay	1.8	2.6	3.0	-1.2	1.6	1.7	1.7	-1.7	-1.7
Delay disc. indifference point, 2s delay	2.8	3.1	4.0	-1.0	1.6	2.0	1.8	-2.0	-2.0
Delay disc. indifference point, 24s delay	0.6	0.9	1.1	-0.7	1.0	1.0	1.0	-1.0	-1.0
Delay disc. indifference point, 4s delay	4.5	4.8	5.6	-1.2	2.3	2.4	2.3	-2.4	-2.4
Delay disc. indifference point, 8s delay	1.4	2.4	2.8	-0.8	1.6	1.7	1.7	-1.7	-1.7
Indifference point function ln k	0.0	0.0	0.1	-0.0	-0.3	0.2	-0.1	-0.1	-0.1
Indifference point function log k	0.0	0.0	0.1	-0.0	-0.3	0.2	-0.1	-0.1	-0.1
Patch foraging total patch changes 0 sec	2.3	6.7	7.5	-2.7	2.7	2.6	2.7	-2.4	-2.4
Patch foraging total patch changes 12 sec	4.0	5.3	8.3	-2.9	2.4	2.1	2.3	-2.0	-2.0
Patch foraging total patch changes 18 sec	0.2	0.5	0.7	0.6	0.8	0.6	0.8	-0.6	-0.6
Patch foraging total patch changes 24 sec	0.6	2.1	3.3	0.2	1.8	1.4	1.7	-1.4	-1.5
Patch foraging total patch changes 6 sec	2.3	3.8	5.0	-0.2	2.1	2.2	2.2	-2.1	-2.1
Patch foraging time to switch 0 sec	0.3	1.3	4.7	-2.2	1.3	0.6	0.8	-0.6	-0.6
Patch foraging water rate 0 sec	0.1	0.5	2.8	-1.7	-0.3	0.1	-0.2	0.0	0.0
Patch foraging water rate 12 sec	1.3	5.3	20.7	4.5	-2.1	-1.2	-1.5	1.2	1.2
Patch foraging water rate 18 sec	0.2	0.4	1.9	1.4	-0.6	-0.3	-0.4	0.3	0.3
Patch foraging water rate 24 sec	3.1	4.4	17.2	4.2	-1.6	-1.3	-1.3	1.3	1.3
Patch foraging water rate 6 sec	5.7	8.4	23.6	4.9	-2.7	-2.2	-2.3	2.1	2.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.4	0.5	-0.4	-0.6	-0.5	0.5	0.5
Distance traveled before self-admin	0.8	1.8	10.2	-3.2	0.1	-0.3	-0.2	0.4	0.4
Distance traveled after self-admin	2.0	3.5	10.1	-3.2	1.6	1.4	1.5	-1.4	-1.4
Extensor digitorum longus weight	0.0	0.1	0.3	0.5	0.2	0.2	0.2	-0.2	-0.2
Bone: elastic displacement	1.3	1.6	9.7	3.1	-0.3	0.2	0.1	-0.2	-0.2
Bone: elastic work	2.4	3.2	17.1	4.1	-0.8	-0.6	-0.6	0.6	0.6
Bone: endosteal estimation	2.1	5.0	6.3	-1.5	2.0	2.5	2.2	-2.5	-2.5
Bone: endosteal perimeter	1.7	4.3	5.7	-0.9	1.8	2.4	2.1	-2.4	-2.4
Epididymis fat weight	0.1	0.6	0.8	-0.9	0.7	0.7	0.7	-0.7	-0.7
Delta time in closed arm before/after self-admin	1.4	1.3	3.2	1.8	0.8	1.0	1.0	-1.0	-1.0
Delta time in open arm before/after self-admin	0.3	0.4	2.0	-1.4	0.1	0.3	0.2	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.5	0.9	1.2	-1.1	-0.9	-0.8	-0.9	0.9	0.9
Delay discount exponential model param	2.4	3.3	4.0	1.0	-1.8	-2.0	-1.9	2.0	2.0
Extinction: sum of active levers before priming	0.6	0.9	4.9	-2.2	0.6	0.1	0.4	-0.2	-0.2
Active lever presses in extinction session 6	1.1	1.1	1.5	-1.1	-0.7	-1.2	-1.0	1.2	1.2
Bone: final force	1.5	2.4	10.1	3.2	-1.4	-0.8	-1.0	0.7	0.7
Bone: final moment	1.3	2.1	9.7	3.1	-1.2	-0.6	-0.8	0.6	0.6
Food consumed during 24 hour testing period	2.2	4.4	13.7	-3.7	-1.5	-1.4	-1.7	1.7	1.7
Glucose	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.2	0.1	0.1
Heart weight	0.0	0.0	0.0	0.0	0.2	0.1	0.1	-0.2	-0.2
Delay discount hyperbolic model param	2.6	3.3	4.0	1.1	-1.8	-2.0	-1.9	2.0	2.0
Intermittent access intake day 1-15 change	0.0	0.1	0.2	-0.1	0.4	0.2	0.3	-0.2	-0.2
Intermittent access intake escalation	0.0	0.1	0.2	-0.1	0.5	0.2	0.4	-0.2	-0.3
Intermittent access intake escalation 2	0.0	0.0	0.0	0.2	0.2	0.1	0.2	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.3	1.3	1.2	0.2	0.3	0.3	-0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.8	0.9	-0.6	-0.4	-0.5	0.4	0.4
Intermitt. access escalation Index	0.0	0.0	0.1	-0.1	0.0	0.3	0.1	-0.3	-0.3
Intermittent access day 1 total infusions	0.0	0.0	0.2	-0.2	0.4	-0.0	0.2	0.0	0.0
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.3	0.5	-0.0	0.2	0.0	0.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.4	0.0	-0.4	-0.2	0.4	0.4
Intermittent access total infusions	0.1	0.1	0.1	0.1	0.2	-0.4	-0.1	0.3	0.3
Intermittent access day 1 locomotion	1.4	2.7	4.1	-0.9	2.0	1.6	1.9	-1.6	-1.6
Intermittent access day 15 total locomotion	0.2	0.9	1.6	-0.7	1.3	0.8	1.1	-0.8	-0.8
Intermittent access total locomotion	1.2	1.4	2.5	-0.8	1.6	1.1	1.4	-1.1	-1.1
Intermittent access standard deviation	0.1	0.4	0.7	0.8	-0.4	-0.7	-0.5	0.7	0.7
Left kidney weight	0.0	0.4	1.5	1.2	-0.4	-0.4	-0.3	0.4	0.4
Right kidney weight	0.0	0.0	0.0	0.2	0.1	0.1	0.2	-0.1	-0.1
Cocaine induced anxiety	0.1	0.2	0.3	0.6	0.3	0.3	0.4	-0.3	-0.3
Post-drug Anxiety	2.5	2.8	5.2	2.3	-1.5	-1.5	-1.5	1.5	1.5
Baseline Anxiety	4.6	7.8	8.0	2.6	-2.8	-2.8	-2.8	2.8	2.8
Tail length	0.8	4.3	12.1	-3.5	1.6	1.8	1.6	-1.7	-1.6
Length with tail	0.2	0.9	5.1	-2.3	0.0	0.1	-0.0	-0.0	-0.0
Length without tail	0.6	3.4	5.1	2.3	-1.7	-1.8	-1.7	1.7	1.7
Times rat made contact with spout	7.0	8.0	45.5	-6.7	-0.3	-0.5	-0.8	0.9	0.9
Lifetime Intake	0.1	0.1	0.2	0.3	0.1	-0.5	-0.2	0.5	0.5
Liver weight, left	0.4	0.8	1.1	1.1	-0.8	-0.8	-0.8	0.8	0.8
Liver weight, right	1.3	2.2	6.4	2.5	-1.2	-1.2	-1.1	1.2	1.2
Locomotor activity	2.4	3.8	22.1	4.7	-0.7	-0.2	-0.3	0.1	0.1
Locomotor testing distance	0.5	1.2	3.1	1.8	0.6	1.0	0.9	-1.0	-1.0
Locomotor testing rearing	0.2	0.7	2.5	1.6	0.3	0.6	0.6	-0.6	-0.6
Locomotion in novel chamber	0.1	0.2	0.5	0.6	-0.7	-0.2	-0.4	0.2	0.2
Locomotion in novel chamber post-restriction	0.2	0.5	1.0	-0.6	-1.0	-0.4	-0.8	0.6	0.6
Fecal boli incidents, locomotor time 1	0.7	1.7	2.2	0.7	-1.2	-1.5	-1.4	1.5	1.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.2	0.2	0.3	0.3	-0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.5	0.6	0.8	-0.5	0.9	0.7	0.8	-0.8	-0.8
Bouts of movement, locomotor time 1	2.1	2.8	3.5	0.2	-1.7	-1.9	-1.8	1.9	1.9
Total resting periods, locomotor time 1	3.1	3.6	4.6	0.2	-1.8	-2.1	-2.0	2.1	2.2
Rest time, locomotor task time 1	2.7	4.3	5.5	0.9	-1.9	-2.4	-2.2	2.3	2.3
Distance moved, locomotor task time 1	1.8	5.0	5.9	-1.6	2.2	2.4	2.3	-2.4	-2.4
Vertical activity count, locomotor time 1	0.3	2.0	2.9	-0.4	1.2	1.7	1.5	-1.7	-1.7
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	-0.1	0.4	0.7	0.6	-0.7	-0.7
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1	0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.4	-0.2	-0.3	-0.3	0.3	0.3
Rest time, locomotor task time 2	1.9	3.3	4.6	0.0	-1.5	-2.1	-1.9	2.1	2.1
Distance moved, locomotor task time 2	3.2	4.3	5.8	-0.3	1.9	2.4	2.2	-2.4	-2.4
Vertical activity count, locomotor time 2	1.2	2.8	4.0	1.5	0.7	2.0	1.4	-2.0	-2.0
Light reinforcement 1	0.2	0.7	0.9	0.2	0.8	0.9	0.9	-0.9	-0.9
Light reinforcement 2	0.4	0.9	4.4	2.1	-0.3	-0.5	-0.3	0.4	0.4
Bone: marrow area	2.1	5.0	6.3	-1.5	2.0	2.5	2.2	-2.5	-2.5
Bone: maximum diameter	0.7	1.4	7.6	2.7	-0.8	0.1	-0.3	-0.1	-0.1
Bone: maximum force	1.2	2.3	8.6	2.9	-1.3	-0.9	-1.1	0.9	0.9
Bone: maximum moment	1.0	1.9	8.1	2.8	-1.0	-0.7	-0.8	0.7	0.7
Mean time between licks in bursts	0.0	0.2	0.2	-0.4	-0.4	-0.5	-0.5	0.5	0.5
Mean num. licks in bursts	3.2	8.6	47.4	-6.9	1.1	1.1	0.8	-0.8	-0.8
Cd content in liver	1.7	1.9	2.1	-0.9	1.4	1.4	1.4	-1.4	-1.4
Co content in liver	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.2	0.2
Cu content in liver	3.8	4.5	7.8	-2.8	2.1	1.9	2.0	-1.9	-1.9
Fe content in liver	1.2	1.5	2.0	0.0	1.1	1.4	1.3	-1.4	-1.4
K content in liver	1.5	1.5	6.4	2.5	-0.6	-0.8	-0.6	0.7	0.7
Mg content in liver	0.5	0.5	2.7	1.6	-0.1	-0.4	-0.1	0.3	0.3
Mn content in liver	2.6	3.0	3.6	1.1	-1.6	-1.9	-1.8	1.9	1.9
Na content in liver	0.4	0.5	2.5	1.6	-0.5	-0.1	-0.2	0.0	0.0
Rb content in liver	0.2	0.3	0.7	0.9	-0.1	-0.6	-0.3	0.5	0.5
Se content in liver	0.2	0.2	1.4	1.2	-0.1	-0.1	-0.0	0.1	0.0
Sr content in liver	0.4	0.4	0.4	-0.4	0.6	0.6	0.6	-0.6	-0.6
Zn content in liver	2.6	3.0	4.0	-0.9	2.0	1.8	1.9	-1.8	-1.8
Bone: minimum diameter	0.5	1.0	1.4	-0.7	0.6	1.2	0.9	-1.2	-1.2
Time in familiar zone, hab. session 1	1.0	1.1	1.4	1.2	0.8	1.0	1.0	-1.1	-1.1
Time in novel zone, hab. session 1	1.1	1.3	3.1	-1.8	-0.6	-1.0	-0.9	1.1	1.1
Total zone transitions, hab. session 1	3.9	5.5	32.5	-5.7	0.6	0.4	0.2	-0.2	-0.2
Total locomotion distance, hab. session 1	3.3	4.8	26.9	-5.2	-0.1	-0.5	-0.6	0.7	0.7
Locomotion velocity, hab. session 1	2.4	3.4	19.0	-4.4	-0.3	-0.4	-0.6	0.6	0.6
Time in familiar zone, hab. session 2	0.8	0.9	5.3	-2.3	0.2	0.3	0.1	-0.3	-0.3
Time in novel zone, hab. session 2	0.5	0.5	2.9	1.7	-0.2	-0.3	-0.1	0.3	0.2
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.1	0.6	0.6	0.6	-0.6	-0.6
Total locomotion distance, hab. session 2	1.0	1.2	7.0	-2.6	0.3	0.4	0.2	-0.3	-0.3
Locomotion velocity, hab. session 2	0.7	0.9	5.4	-2.3	0.0	0.1	-0.1	-0.1	-0.1
Novel to familiar place preference ratio	1.4	1.8	8.3	-2.9	1.1	0.6	0.7	-0.5	-0.5
Novelty place preference	1.3	1.6	9.0	-3.0	0.7	0.3	0.4	-0.2	-0.2
Time in novel zone, NPP test	1.8	2.1	11.1	-3.3	0.9	0.5	0.6	-0.4	-0.4
Total zone transitions, NPP test	4.4	6.5	18.9	-4.3	2.2	2.0	2.0	-1.9	-1.9
Total locomotion distance, NPP test	2.0	2.7	11.9	-3.4	1.2	0.9	0.9	-0.8	-0.8
Locomotion velocity, NPP test	1.4	1.9	9.2	-3.0	0.9	0.7	0.7	-0.6	-0.6
Intraocular pressure	0.1	0.1	0.5	-0.7	0.4	0.1	0.2	-0.0	-0.0
Delta distance traveled before/after self-admin	2.1	2.3	3.1	-0.3	1.5	1.7	1.7	-1.7	-1.7
Delta ambulatory time before/after self-admin	1.4	2.4	3.1	0.3	1.5	1.7	1.7	-1.7	-1.7
Parametrial fat weight	0.5	1.2	6.4	2.5	0.4	0.3	0.5	-0.4	-0.4
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.2	0.3	0.2	0.3	-0.2	-0.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.5	1.2	-0.9	-0.9	-0.9	0.9	0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.5	-0.2	-0.2	-0.2	0.2	0.2
Pavlov. Cond. index score	0.2	0.3	1.0	1.0	-0.4	-0.4	-0.4	0.4	0.4
Pavlov. Cond. latency score	0.2	0.2	0.7	0.8	-0.4	-0.4	-0.4	0.4	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.1	-0.0	0.1	0.0	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.5	0.7	2.9	-1.7	0.5	0.5	0.4	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	5.8	7.0	19.2	-4.4	2.6	2.0	2.2	-1.9	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.7	0.8	-0.2	-0.2	-0.2	0.2	0.2
Pavlov. Cond. response bias	0.3	0.4	0.4	0.5	-0.6	-0.6	-0.6	0.6	0.6
Pavlov. Cond. lever latency	1.1	1.6	1.9	-0.6	1.3	1.4	1.4	-1.3	-1.3
Pavlov. Cond. magazine entry latency	2.7	3.8	10.0	3.2	-1.9	-1.5	-1.7	1.4	1.4
Pavlov. Cond. change in total contacts	0.5	1.2	1.4	1.0	-1.2	-1.1	-1.2	1.0	1.0
Pavlov. Cond. index score	0.9	1.5	1.9	1.2	-1.4	-1.2	-1.3	1.1	1.1
Pavlov. Cond. latency score	1.3	2.1	2.6	1.6	-1.6	-1.4	-1.5	1.3	1.3
Pavlov. Cond. lever contacts	0.9	1.4	1.8	-0.1	-1.1	-1.4	-1.3	1.3	1.3
Pavlov. Cond. magazine entry number	1.6	2.0	4.4	-2.1	1.5	1.2	1.3	-1.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.6	1.4	3.6	-1.9	1.2	0.9	1.0	-0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.2	1.5	1.2	-1.2	-1.0	-1.1	0.9	0.9
Pavlov. Cond. response bias	1.3	1.8	2.2	0.6	-1.4	-1.5	-1.5	1.4	1.4
Time in closed arm before self-admin	0.0	0.1	0.1	0.4	0.0	0.3	0.2	-0.3	-0.3
Time in closed arm after self-admin	2.5	2.8	5.5	2.3	1.3	1.5	1.5	-1.6	-1.6
Time in open arm before self-admin	0.5	0.6	3.3	1.8	0.1	-0.5	-0.1	0.3	0.3
Time in open arm after self-admin	0.8	0.9	0.9	-1.0	-0.9	-0.9	-1.0	0.9	0.9
Bone: periosteal estimation	0.4	0.8	1.2	1.1	0.3	1.0	0.7	-1.1	-1.0
Bone: periosteal perimeter	0.3	0.6	2.0	1.4	-0.1	0.7	0.4	-0.7	-0.7
Bone: post-yield work	2.1	3.6	8.6	-2.9	1.7	1.6	1.6	-1.6	-1.6
Progressive ratio test 1 active lever presses	0.1	0.2	0.7	-0.4	0.8	0.3	0.6	-0.3	-0.3
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	-0.4	0.9	0.3	0.6	-0.3	-0.3
Progressive ratio test 1 inactive lever presses	0.5	1.2	2.9	1.7	-0.9	-1.0	-0.9	1.0	1.0
Progressive ratio test 2 active lever presses	0.7	1.0	1.2	1.0	-0.7	-1.1	-0.9	1.1	1.1
Progressive ratio test 2 breakpoint	0.8	1.0	1.2	1.0	-0.7	-1.1	-0.9	1.1	1.1
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.4	1.2	-0.6	-0.8	-0.7	0.8	0.8
Incentive Sensitization - Responses	0.5	1.4	1.5	1.0	-1.1	-1.2	-1.2	1.2	1.2
Incentive Sensitization - Breakpoint	0.6	1.4	1.6	1.0	-1.1	-1.3	-1.2	1.3	1.3
Sum of active levers in priming session hrs 5-6	2.0	1.8	2.3	-1.5	-1.0	-1.5	-1.3	1.4	1.4
Progressive ratio	0.7	2.0	6.2	-2.5	1.1	1.2	1.1	-1.0	-1.0
Food seeking constrained by brief footshock	0.4	0.5	1.0	-0.4	0.3	1.0	0.6	-0.8	-0.8
Seeking ratio, punishment vs. effort	0.5	1.0	4.9	2.2	-0.7	-0.5	-0.5	0.4	0.4
Retroperitoneal fat weight	0.2	0.9	1.1	-0.7	1.0	1.0	1.0	-1.0	-1.0
Reaction time number correct	0.1	0.2	0.4	0.6	0.3	0.4	0.3	-0.4	-0.4
Reaction time mean minus median	0.4	2.7	6.3	2.5	-1.7	-1.4	-1.5	1.2	1.2
Reaction time mean minus median AUC	0.3	2.3	3.8	1.3	-1.9	-1.4	-1.7	1.4	1.4
Reaction time num false alarms	0.9	1.5	2.0	0.8	-1.1	-1.3	-1.2	1.4	1.4
Reaction time num false alarms AUC	0.7	1.6	2.2	0.4	-1.1	-1.4	-1.3	1.5	1.5
Reaction time trials correct on left	0.1	0.2	0.4	0.6	0.3	0.4	0.3	-0.4	-0.4
Reaction time trials on left	0.0	0.2	0.5	0.7	0.2	0.3	0.2	-0.3	-0.3
Reaction time mean	0.9	1.9	2.4	1.1	-1.5	-1.4	-1.5	1.3	1.3
Reaction time mean AUC	1.0	2.4	3.1	1.2	-1.7	-1.6	-1.7	1.5	1.5
Median of all reaction times	0.9	1.4	1.7	0.3	-1.3	-1.3	-1.3	1.2	1.2
Reaction time omissions	1.1	1.8	2.6	1.6	-1.4	-1.3	-1.3	1.2	1.2
Reaction time false alarm rate	0.9	1.2	1.8	-0.1	-0.9	-1.3	-1.1	1.3	1.3
Reaction time premature initiation rate	2.3	3.6	15.7	4.0	-1.1	-1.3	-1.0	1.1	1.0
Reaction time premature initiations	0.8	2.5	9.6	3.1	-1.0	-1.1	-1.0	1.0	1.0
Std. dev. reaction times	0.3	1.0	2.2	1.5	-1.2	-0.8	-1.0	0.7	0.7
Reaction time trials completed	0.0	0.2	0.5	0.7	0.2	0.3	0.2	-0.3	-0.3
Reaction time trials AUC	0.1	0.2	0.5	0.7	0.3	0.5	0.3	-0.4	-0.4
Run reversals in cocaine runway, females	0.6	0.7	3.9	2.0	-0.5	0.1	-0.1	-0.1	-0.1
Run reversals in cocaine runway, males	2.2	2.4	3.3	1.8	1.1	1.5	1.4	-1.6	-1.6
Latency to leave start box in cocaine runway	1.9	2.7	3.6	0.6	-1.5	-1.9	-1.7	1.8	1.8
Latency to leave start box in cocaine runway, F	2.2	2.7	3.2	1.5	-1.5	-1.8	-1.7	1.7	1.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	-0.4	-0.3	-0.6	-0.5	0.6	0.6
Std. dev. time between licks in bursts	0.2	0.4	2.0	-1.4	0.5	0.2	0.3	-0.3	-0.2
Total sessions with >9 infusions	0.4	0.5	1.1	-0.5	1.0	0.5	0.8	-0.5	-0.5
Short access day 1 total inactive lever presses	0.6	1.3	4.5	2.1	-0.9	-0.8	-0.8	0.7	0.7
Short access day 10 total inactive lever presses	0.0	0.3	1.5	1.2	-0.4	-0.1	-0.2	0.0	0.0
Short access day 1 total infusions	0.2	0.4	0.7	0.7	0.8	0.5	0.7	-0.5	-0.5
Short access day 10 total infusions	0.0	0.1	0.3	-0.2	0.5	-0.1	0.3	0.0	0.0
Short access total infusions	0.0	0.1	0.1	0.3	0.2	-0.3	-0.0	0.3	0.3
Short access day 1 locomotion	1.4	2.3	3.6	-0.6	1.9	1.5	1.8	-1.5	-1.5
Short access day 10 total locomotion	0.6	2.5	3.7	-0.6	1.9	1.6	1.8	-1.6	-1.6
Short access total locomotion	0.6	0.9	1.8	-0.5	1.3	0.8	1.1	-0.8	-0.8
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.1	0.5	0.1	0.3	-0.1	-0.1
Compulsive drug intake	0.1	0.1	0.3	0.5	-0.5	0.0	-0.2	0.0	0.0
One hour access (shock baseline)	0.2	0.4	0.9	-0.7	1.0	0.4	0.7	-0.4	-0.4
Social response proportion	1.8	2.3	7.3	-2.7	-0.8	-1.0	-1.1	1.2	1.2
Social responses	0.5	0.6	2.1	-1.4	-0.4	-0.6	-0.6	0.7	0.7
Social time	0.8	1.2	1.8	-1.1	-1.3	-0.8	-1.2	1.0	1.0
Soleus weight	0.0	0.1	0.5	-0.7	0.3	0.3	0.2	-0.3	-0.3
Bone: stiffness	1.0	1.8	6.6	2.6	-1.1	-0.9	-0.9	0.8	0.8
Tibialis anterior weight	0.1	0.4	1.8	-1.3	0.2	0.3	0.2	-0.2	-0.2
Time to tail flick, vehicle, before self-admin	0.8	0.9	3.3	-1.8	0.7	0.7	0.7	-0.7	-0.7
Time to tail flick, vehicle, after self-admin	0.6	1.2	4.4	2.1	0.5	0.7	0.7	-0.8	-0.8
Time to tail flick, test, before self-admin	0.6	0.7	1.2	0.5	1.1	0.8	0.9	-0.8	-0.8
Time to tail flick, test, after self-admin	1.8	1.9	10.4	3.2	-0.2	-0.7	-0.4	0.5	0.5
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	5.3	2.3	-0.0	0.2	0.1	-0.2	-0.2
Delta time to tail flick, test, before/after SA	1.8	2.3	4.3	2.1	-1.3	-1.5	-1.3	1.3	1.3
Tibia length	0.3	0.8	1.0	0.7	0.9	0.9	1.0	-0.9	-0.9
Ambulatory time before self-admin	0.8	2.4	14.2	-3.8	0.3	-0.2	-0.0	0.2	0.2
Ambulatory time after self-admin	2.4	3.8	11.5	-3.4	1.8	1.4	1.5	-1.4	-1.4
Bone: tissue strength	1.1	1.2	6.3	2.5	0.5	0.2	0.5	-0.3	-0.3
Total heroin consumption	0.2	0.3	0.4	-0.7	-0.3	-0.6	-0.5	0.6	0.6
Bone: trabecular number	1.4	2.6	15.2	-3.9	0.7	0.2	0.3	-0.1	-0.1
Bone: trabecular spacing	1.1	1.7	9.7	3.1	-0.4	-0.3	-0.2	0.2	0.2
Bone: trabecular thickness	0.4	0.6	1.5	-1.2	1.1	0.4	0.7	-0.4	-0.4
Bone: trabecular tissue density	2.7	4.7	6.0	0.3	-2.3	-2.3	-2.4	2.4	2.4
Water consumed over 24 hours	1.7	3.3	11.7	-3.4	-1.1	-1.1	-1.3	1.4	1.4
Number of responses in last shaping day	0.4	0.6	2.2	1.5	-0.4	-0.6	-0.4	0.5	0.5