Hub : Genes

Tspo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio NM_012515.2 0.33 0.2 5.2e-03 0.01 0 0.01 0.01 4.5e-02 1.0e-01 2.4e-02 6.7e-02
2 LHb gene expression Tspo 0.13 0.1 5.4e-03 0.05 0.06 0.05 0.04 2.3e-02 1.8e-02 2.7e-02 4.3e-02
3 pVTA gene expression Tspo 0.09 0.07 8.1e-04 0.06 0.07 0.04 0.06 9.0e-04 5.8e-04 5.6e-03 1.7e-03
4 BLA gene expression Tspo 0.12 0.09 1.9e-06 0.08 0.08 0.07 0.07 4.3e-05 2.9e-05 2.1e-04 1.4e-04
5 NAcc gene expression Tspo 0.06 0.04 1.9e-08 0.07 0.07 0.07 0.06 1.9e-08 1.4e-08 1.8e-08 1.1e-07
6 Brain gene expression Tspo 0.1 0.06 3.7e-12 0.12 0.13 0.13 0.12 1.2e-11 6.6e-12 4.3e-12 1.1e-11
7 Adipose gene expression Tspo 0.38 0.16 0.0e+00 0.21 0.2 0.21 0.21 9.1e-23 7.6e-22 1.8e-22 5.9e-23
8 Liver alternative TSS XM_039078394.1 0.26 0.2 8.5e-03 0.01 0 0 0 5.8e-02 2.1e-01 1.9e-01 9.7e-02
9 PL gene expression Tspo 0.09 0.07 2.5e-09 0.07 0.05 0.05 0.06 2.1e-08 1.3e-06 2.2e-06 1.2e-06
10 Liver alternative TSS NM_012515.2 0.38 0.18 2.5e-03 0.01 0.01 0.01 0.01 3.8e-02 1.7e-02 3.4e-02 6.4e-02
11 Liver gene expression Tspo 0.87 0.02 0.0e+00 0.12 0.23 0.22 0.14 4.4e-13 4.1e-25 6.0e-24 6.5e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.20.40.50.7-0.7-0.7-0.7-0.70.6-0.6-0.60.6-0.2-0.5
Area under the delay curve1.71.82.20.5-1.5-1.4-1.4-1.41.4-1.5-1.51.4-1.5-0.7
BMI with tail1.85.89.9-3.12.32.32.32.3-2.32.52.6-2.52.11.7
BMI without tail0.71.52.3-1.51.11.11.01.1-1.31.31.3-1.21.21.3
Body weight1.56.28.5-2.32.52.62.32.6-2.72.92.9-2.80.82.4
Weight adjusted by age0.10.10.3-0.60.30.30.30.3-0.40.30.3-0.40.50.2
Bone surface0.10.21.90.30.10.10.10.2-0.20.10.0-0.0-0.5-1.4
Bone volume0.10.10.60.4-0.0-0.0-0.00.1-0.1-0.0-0.10.0-0.4-0.8
Breakpoint value in progressive ratio session0.10.10.2-0.30.30.30.20.3-0.40.40.4-0.3-0.30.5
Number of licking bursts0.20.20.70.8-0.4-0.4-0.4-0.40.3-0.4-0.40.5-0.40.4
Context. condit. distance diff. score5.56.67.8-2.72.72.72.82.6-2.42.52.5-2.72.51.9
Locomotion velocity, session 10.80.91.7-0.61.01.01.11.1-1.00.80.8-0.80.5-1.3
Locomotion distance, session 10.50.61.5-0.7-0.6-0.7-0.4-0.60.6-0.8-0.70.81.2-1.0
Locomotion velocity, session 21.21.42.2-1.51.11.01.21.2-1.11.01.1-1.01.3-1.4
Locomotion distance, session 21.01.42.6-0.2-1.2-1.3-1.1-1.31.1-1.3-1.21.40.5-1.6
Locomotion velocity, session 31.11.34.6-1.50.90.81.10.9-0.80.80.9-0.82.2-1.2
Locomotion distance, session 30.80.81.60.1-0.9-1.0-0.8-1.11.2-1.0-0.90.80.9-0.6
Stereotopy head waving bouts, day 30.81.01.6-0.91.01.01.01.2-1.31.11.0-1.00.2-0.8
Stereotopy head waving duration, day 34.55.48.1-2.22.52.52.52.6-2.82.62.5-2.51.30.1
Locomotion velocity, session 70.50.62.6-1.60.10.00.20.1-0.00.20.2-0.51.6-1.0
Locomotion distance, session 70.91.12.9-0.5-1.1-1.1-0.9-1.11.2-1.1-1.00.70.7-1.7
Stereotopy head waving bouts, day 75.35.910.3-3.22.62.62.62.6-2.72.42.4-2.31.90.2
Stereotopy head waving duration, day 73.23.85.2-2.22.12.12.12.2-2.32.12.0-1.91.40.6
Locomotion velocity, session 86.67.910.8-3.32.92.93.02.9-3.02.82.9-2.62.71.4
Locomotion distance, session 81.31.95.1-2.31.41.31.41.3-1.31.11.1-1.11.80.4
Degree of sensitization distance0.70.71.0-0.60.90.90.91.0-1.00.90.9-1.00.1-0.0
Degree of sensitization stereotypy3.94.37.8-2.82.12.12.12.1-2.22.02.1-2.02.00.8
Conditioned locomotion0.10.10.4-0.00.20.20.10.2-0.20.30.2-0.1-0.60.4
Cocaine response after cond. corrected0.10.10.2-0.50.10.10.20.10.1-0.1-0.10.20.5-0.4
Cocaine response after cond. not corrected0.10.10.4-0.50.20.10.30.10.1-0.1-0.10.20.7-0.6
Cocaine response before conditioning0.10.10.30.5-0.3-0.3-0.3-0.30.2-0.3-0.30.4-0.3-0.4
Saline control response0.20.20.40.60.40.50.40.5-0.70.60.4-0.3-0.40.2
Bone: connectivity density0.10.10.40.7-0.4-0.4-0.4-0.30.2-0.2-0.20.2-0.3-0.4
Bone: cortical apparent density1.31.72.21.1-1.3-1.3-1.3-1.31.4-1.4-1.41.3-1.5-0.9
Bone: cortical area1.21.92.6-0.71.61.61.51.6-1.51.51.5-1.50.50.8
Bone: cortical porosity0.40.50.90.10.70.70.70.7-0.70.80.9-0.90.30.1
Bone: cortical porosity0.90.91.50.01.11.11.11.2-1.01.11.2-1.20.2-0.1
Bone: cortical thickness0.30.52.31.20.00.2-0.10.1-0.30.30.3-0.3-1.41.5
Bone: cortical thickness0.50.64.8-0.40.50.50.40.4-0.40.50.4-0.60.22.2
Bone: cortical tissue density1.21.61.91.0-1.3-1.3-1.3-1.21.4-1.3-1.31.3-1.4-0.8
Condit. Reinf. active minus inactive responses1.51.73.70.4-1.3-1.2-1.2-1.11.1-1.4-1.31.4-1.6-1.9
Condit. Reinf. active-inactive response ratio0.20.21.7-0.20.10.10.10.2-0.2-0.00.0-0.0-0.8-1.3
Condit. Reinf. active responses3.54.35.21.5-2.1-2.1-2.1-2.12.1-2.3-2.22.3-2.0-2.0
Condit. Reinf. inactive responses3.44.15.02.1-2.2-2.2-2.2-2.22.2-2.2-2.12.2-1.2-1.0
Incentive salience index mean2.53.14.61.4-1.7-1.7-1.7-1.61.6-1.8-1.71.8-2.1-2.0
Condit. Reinf. lever presses2.73.65.41.9-1.8-1.8-1.8-1.71.7-1.9-1.91.9-2.0-2.3
Condit. Reinf. active minus inactive responses0.20.20.80.20.20.20.20.3-0.50.20.3-0.1-0.9-0.9
Condit. Reinf. active-inactive response ratio0.20.21.0-0.10.30.30.30.4-0.50.20.2-0.1-0.9-1.0
Condit. Reinf. active responses0.60.81.5-0.11.01.01.01.1-1.20.90.9-0.8-0.5-1.0
Condit. Reinf. inactive responses0.60.81.2-0.11.01.01.11.1-1.10.90.9-1.00.3-0.4
Condit. Reinf. lever presses0.50.74.01.1-0.3-0.3-0.3-0.20.4-0.6-0.60.7-0.9-2.0
Condit. Reinf. lever reinforcers received0.40.63.00.40.50.50.50.6-0.70.30.3-0.2-1.1-1.7
Conditioned reinforcement - actives0.50.52.01.3-0.4-0.3-0.4-0.30.5-0.4-0.50.5-1.4-1.0
Conditioned reinforcement - inactives0.10.10.5-0.7-0.1-0.2-0.1-0.20.2-0.1-0.20.00.50.2
Conditioned locomotion0.50.60.90.10.91.01.00.9-0.80.90.8-0.70.30.2
Patch foraging indifference point 0 sec0.10.10.20.4-0.3-0.3-0.4-0.30.3-0.3-0.30.3-0.4-0.4
Patch foraging indifference point AUC0.30.41.90.7-0.4-0.4-0.4-0.40.6-0.5-0.40.4-0.6-1.4
Delay disc. indifference point, 0s delay0.30.40.8-0.90.50.50.50.5-0.50.60.7-0.80.60.1
Delay disc. indifference point, 16s delay3.53.54.91.0-2.0-1.9-2.0-1.91.9-2.0-2.12.0-2.2-1.3
Delay disc. indifference point, 2s delay0.30.30.50.2-0.7-0.7-0.7-0.70.7-0.6-0.60.5-0.1-0.2
Delay disc. indifference point, 24s delay0.60.61.11.0-0.8-0.7-0.7-0.70.7-0.8-0.70.7-1.0-0.3
Delay disc. indifference point, 4s delay0.30.31.8-1.3-0.3-0.3-0.2-0.30.4-0.5-0.40.30.3-0.6
Delay disc. indifference point, 8s delay2.72.83.51.4-1.8-1.8-1.8-1.81.9-1.8-1.81.8-1.6-0.5
Indifference point function ln k1.62.24.1-1.41.31.31.21.4-1.61.61.6-1.71.02.0
Indifference point function log k1.62.24.1-1.41.31.31.21.4-1.61.61.6-1.71.02.0
Patch foraging total patch changes 0 sec0.10.10.20.4-0.4-0.4-0.5-0.40.4-0.4-0.30.3-0.3-0.3
Patch foraging total patch changes 12 sec0.30.43.90.10.30.20.40.3-0.10.00.00.10.2-2.0
Patch foraging total patch changes 18 sec0.30.42.21.2-0.3-0.2-0.3-0.10.0-0.2-0.10.1-1.5-0.5
Patch foraging total patch changes 24 sec0.30.31.90.3-0.4-0.4-0.3-0.40.5-0.5-0.40.40.1-1.4
Patch foraging total patch changes 6 sec0.00.00.20.30.00.10.10.1-0.00.10.1-0.1-0.1-0.5
Patch foraging time to switch 0 sec0.50.83.40.6-0.7-0.7-0.6-0.60.6-0.9-0.91.0-0.8-1.8
Patch foraging water rate 0 sec0.81.33.3-0.91.01.01.00.8-0.71.01.1-1.21.81.7
Patch foraging water rate 12 sec0.91.45.8-1.40.80.70.80.7-0.81.00.9-1.12.41.1
Patch foraging water rate 18 sec0.20.21.6-1.3-0.0-0.10.0-0.10.2-0.1-0.20.10.7-0.5
Patch foraging water rate 24 sec1.62.23.6-0.21.51.61.41.7-1.91.91.8-1.70.21.3
Patch foraging water rate 6 sec0.10.20.3-0.6-0.4-0.5-0.4-0.40.4-0.3-0.30.20.4-0.5
Seeking ratio, delayed vs. immediate footshock2.32.66.22.5-1.7-1.8-1.7-1.81.6-1.5-1.51.2-0.0-1.1
Distance traveled before self-admin0.40.43.01.7-0.2-0.3-0.1-0.30.4-0.4-0.50.30.4-1.0
Distance traveled after self-admin0.20.20.30.40.50.50.50.5-0.50.50.4-0.50.2-0.2
Extensor digitorum longus weight0.10.32.00.20.20.10.10.00.10.20.3-0.30.81.4
Bone: elastic displacement1.41.62.2-1.51.31.21.31.2-1.31.21.3-1.31.30.6
Bone: elastic work4.25.46.7-2.62.52.52.62.5-2.52.42.3-2.32.10.9
Bone: endosteal estimation2.86.212.7-3.62.52.32.72.4-2.01.91.9-2.03.5-1.7
Bone: endosteal perimeter2.14.47.6-2.82.22.12.42.3-2.01.81.8-1.92.3-0.9
Epididymis fat weight0.92.23.3-0.81.61.71.41.7-1.71.81.8-1.7-0.70.1
Delta time in closed arm before/after self-admin0.10.10.40.10.10.10.10.10.0-0.1-0.10.1-0.4-0.6
Delta time in open arm before/after self-admin0.40.43.6-0.40.40.30.60.3-0.10.20.2-0.21.9-0.4
Diff in mean of infusions in LGA sessions1.01.11.60.4-1.1-1.0-1.0-1.11.3-1.3-1.11.1-0.8-1.1
Delay discount exponential model param1.61.62.0-0.61.41.41.41.4-1.41.41.4-1.31.40.6
Extinction: sum of active levers before priming0.40.41.4-0.1-0.3-0.3-0.2-0.30.8-0.7-0.80.6-0.1-1.2
Active lever presses in extinction session 60.70.72.1-1.40.80.70.70.7-0.70.70.7-0.60.80.8
Bone: final force0.71.11.8-0.91.31.31.31.3-1.11.01.0-1.00.60.2
Bone: final moment1.22.02.9-1.31.71.71.71.7-1.51.41.3-1.31.00.4
Food consumed during 24 hour testing period2.53.15.2-2.31.81.81.81.8-1.71.71.6-1.61.81.2
Glucose0.50.81.21.1-1.0-1.0-1.0-1.00.9-0.7-0.60.8-0.6-0.8
Heart weight2.23.27.1-1.01.81.91.71.8-1.81.91.8-1.80.02.7
Delay discount hyperbolic model param1.11.21.5-0.31.21.21.21.2-1.21.21.2-1.11.10.5
Intermittent access intake day 1-15 change1.01.02.51.6-0.9-0.8-0.9-0.80.9-0.8-0.91.1-1.3-0.7
Intermittent access intake escalation0.80.82.41.6-0.7-0.7-0.8-0.70.7-0.7-0.80.9-1.1-0.4
Intermittent access intake escalation 20.20.20.20.4-0.4-0.4-0.4-0.40.5-0.3-0.40.4-0.4-0.4
Intermitt. access day 1 inactive lever presses1.31.45.0-2.21.11.01.11.0-0.80.91.0-0.91.60.3
Intermitt. access day 15 inactive lever presses0.60.61.6-1.30.90.91.00.9-0.80.60.5-0.50.60.1
Intermitt. access escalation Index0.10.10.2-0.3-0.3-0.3-0.3-0.30.3-0.3-0.40.3-0.2-0.4
Intermittent access day 1 total infusions0.70.81.2-0.90.90.90.90.9-0.90.90.9-1.10.70.6
Intermittent access day 15 total infusions0.00.00.20.20.20.20.20.2-0.10.20.1-0.20.50.0
Intermittent access terminal intake (last 3 days)0.10.10.6-0.30.10.00.20.00.20.0-0.0-0.10.7-0.8
Intermittent access total infusions0.30.31.2-0.70.50.40.60.4-0.30.30.3-0.51.1-0.2
Intermittent access day 1 locomotion0.10.10.5-0.70.20.20.20.2-0.20.20.3-0.30.10.4
Intermittent access day 15 total locomotion0.10.10.7-0.10.40.30.40.3-0.20.20.2-0.20.80.3
Intermittent access total locomotion0.30.31.4-0.50.50.40.60.4-0.30.40.4-0.51.20.2
Intermittent access standard deviation0.50.51.8-1.30.70.70.70.7-0.60.60.5-0.50.90.0
Left kidney weight11.733.044.4-5.36.56.66.46.7-6.46.36.1-6.02.62.1
Right kidney weight13.538.047.9-5.86.86.96.86.9-6.86.76.5-6.33.93.0
Cocaine induced anxiety2.22.65.4-1.31.81.71.91.7-1.61.61.4-1.32.30.5
Post-drug Anxiety2.02.23.2-1.71.51.41.51.4-1.51.61.5-1.51.81.0
Baseline Anxiety1.61.74.20.9-1.6-1.4-1.7-1.41.1-1.0-0.80.9-2.10.4
Tail length0.10.41.31.0-0.3-0.2-0.4-0.2-0.10.10.10.1-1.11.1
Length with tail0.20.81.40.10.70.90.61.0-1.11.11.1-1.0-1.20.5
Length without tail0.30.71.1-0.60.90.90.91.0-0.91.01.0-1.0-0.3-0.8
Times rat made contact with spout2.12.45.4-1.21.41.41.31.3-1.51.61.5-1.51.62.3
Lifetime Intake0.40.51.2-0.50.80.70.90.8-0.60.60.6-0.71.1-0.2
Liver weight, left0.10.20.6-0.10.50.50.50.6-0.80.50.5-0.5-0.2-0.5
Liver weight, right0.30.51.1-0.30.60.70.60.8-0.90.60.6-0.6-1.1-0.4
Locomotor activity2.23.64.6-2.22.12.12.12.2-2.12.02.0-1.90.90.2
Locomotor testing distance0.10.20.9-0.80.0-0.00.10.00.1-0.3-0.20.30.5-0.9
Locomotor testing rearing0.30.40.8-0.10.90.90.90.9-0.70.50.6-0.50.1-0.3
Locomotion in novel chamber0.20.20.5-0.6-0.5-0.5-0.6-0.50.5-0.3-0.20.4-0.5-0.7
Locomotion in novel chamber post-restriction0.91.12.01.4-1.0-1.1-1.0-1.11.1-1.1-1.11.0-0.3-0.9
Fecal boli incidents, locomotor time 10.40.42.11.4-0.4-0.5-0.3-0.40.5-0.6-0.80.7-0.1-0.6
Change in fecal boli incidents, locomotor task0.80.71.5-1.20.80.80.70.8-0.90.91.1-0.80.30.8
Time >=10cm from walls, locomotor time 10.40.42.1-1.20.0-0.00.20.00.2-0.3-0.10.10.6-1.4
Bouts of movement, locomotor time 10.30.42.31.5-0.4-0.4-0.4-0.40.4-0.4-0.40.5-0.6-0.1
Total resting periods, locomotor time 10.50.52.41.5-0.6-0.6-0.6-0.60.6-0.7-0.60.7-0.6-0.2
Rest time, locomotor task time 10.10.10.20.4-0.2-0.2-0.2-0.20.2-0.2-0.10.10.3-0.3
Distance moved, locomotor task time 10.20.20.7-0.80.40.40.40.5-0.50.40.4-0.2-0.4-0.1
Vertical activity count, locomotor time 10.00.00.1-0.20.20.20.20.2-0.20.20.1-0.1-0.0-0.1
Time >=10cm from walls, locomotor time 20.30.30.40.2-0.6-0.6-0.6-0.60.6-0.7-0.50.6-0.3-0.6
Bouts of movement, locomotor time 20.30.31.30.6-0.4-0.4-0.5-0.40.4-0.4-0.40.4-1.1-0.1
Total resting periods, locomotor time 20.30.31.60.7-0.4-0.4-0.5-0.40.3-0.4-0.40.4-1.30.1
Rest time, locomotor task time 20.20.31.01.0-0.5-0.5-0.6-0.50.3-0.3-0.30.2-0.70.3
Distance moved, locomotor task time 20.80.92.6-1.60.90.90.90.9-0.80.71.0-0.71.10.1
Vertical activity count, locomotor time 20.70.71.3-1.10.90.91.00.9-0.90.81.0-0.70.80.3
Light reinforcement 10.20.40.80.30.80.80.80.9-0.90.50.5-0.60.1-0.4
Light reinforcement 20.40.51.30.10.80.70.70.9-1.10.80.8-0.90.40.0
Bone: marrow area3.16.713.4-3.72.62.42.82.5-2.12.02.0-2.13.6-1.7
Bone: maximum diameter5.29.611.8-3.43.43.43.43.4-3.23.13.2-3.22.70.9
Bone: maximum force2.44.15.3-1.92.32.32.32.3-2.12.12.0-2.01.70.9
Bone: maximum moment3.15.47.0-2.22.62.62.62.6-2.42.42.3-2.42.01.1
Mean time between licks in bursts0.91.32.41.5-1.1-1.1-1.1-1.21.2-1.3-1.31.2-1.00.0
Mean num. licks in bursts2.12.63.8-2.01.51.51.51.5-1.51.61.6-1.71.61.4
Cd content in liver2.22.410.8-0.91.41.41.31.2-1.31.41.4-1.40.83.3
Co content in liver1.11.27.1-0.50.80.90.70.7-1.01.00.9-0.90.62.7
Cu content in liver6.07.38.22.9-2.8-2.7-2.8-2.72.5-2.8-2.82.8-2.8-2.2
Fe content in liver0.30.40.5-0.50.70.70.70.7-0.70.70.7-0.70.3-0.6
K content in liver0.60.62.60.5-0.6-0.6-0.6-0.40.3-0.6-0.60.6-1.0-1.6
Mg content in liver1.11.14.60.7-1.0-0.9-0.9-0.80.6-0.8-0.80.9-1.1-2.1
Mn content in liver0.10.10.3-0.20.20.20.20.2-0.40.20.1-0.1-0.1-0.5
Na content in liver1.51.62.50.8-1.6-1.6-1.5-1.61.4-1.2-1.21.1-0.1-0.7
Rb content in liver0.10.10.60.30.00.10.10.2-0.30.10.1-0.0-0.7-0.8
Se content in liver1.51.94.21.3-1.2-1.2-1.2-1.11.2-1.3-1.31.2-1.7-2.1
Sr content in liver1.21.12.71.1-1.0-1.0-1.1-1.11.1-0.9-0.90.9-0.41.6
Zn content in liver0.91.02.01.4-1.0-1.0-1.1-1.00.9-0.9-1.01.0-1.20.3
Bone: minimum diameter0.50.91.6-0.21.21.21.21.3-1.10.90.8-0.80.3-0.6
Time in familiar zone, hab. session 10.30.31.1-0.70.50.40.50.4-0.30.40.3-0.41.00.0
Time in novel zone, hab. session 10.90.92.10.20.91.00.80.9-1.11.01.0-1.1-0.41.4
Total zone transitions, hab. session 11.82.63.41.8-1.7-1.7-1.7-1.71.5-1.6-1.71.7-1.1-1.0
Total locomotion distance, hab. session 10.40.61.70.4-0.8-0.8-0.8-0.70.6-0.7-0.80.7-0.6-1.3
Locomotion velocity, hab. session 10.60.92.80.1-0.9-1.0-0.9-0.90.8-0.9-0.90.9-0.3-1.7
Time in familiar zone, hab. session 20.20.30.70.7-0.4-0.3-0.4-0.40.3-0.4-0.40.3-0.90.7
Time in novel zone, hab. session 20.90.91.3-1.10.90.91.00.9-1.01.11.1-1.01.00.5
Total zone transitions, hab. session 20.20.32.0-0.2-0.2-0.2-0.1-0.20.1-0.3-0.20.40.6-1.4
Total locomotion distance, hab. session 20.10.20.7-0.2-0.4-0.4-0.3-0.30.3-0.4-0.40.50.1-0.8
Locomotion velocity, hab. session 20.40.51.20.0-0.7-0.7-0.7-0.70.6-0.7-0.70.80.0-1.1
Novel to familiar place preference ratio3.03.16.7-0.91.81.91.61.8-1.91.91.8-1.8-0.02.6
Novelty place preference3.94.08.5-1.22.02.11.92.0-2.22.12.1-2.10.22.9
Time in novel zone, NPP test5.25.49.9-1.52.42.52.22.4-2.52.52.4-2.50.53.1
Total zone transitions, NPP test0.50.71.30.0-0.9-0.9-0.8-0.90.9-1.0-1.11.10.3-0.8
Total locomotion distance, NPP test0.20.30.5-0.3-0.5-0.6-0.4-0.50.6-0.7-0.70.70.4-0.7
Locomotion velocity, NPP test1.01.42.20.2-1.2-1.3-1.2-1.31.3-1.4-1.41.5-0.1-1.2
Intraocular pressure0.50.81.6-1.30.80.70.80.7-0.60.80.7-0.81.20.9
Delta distance traveled before/after self-admin2.22.35.1-2.31.51.51.41.5-1.61.71.6-1.60.91.0
Delta ambulatory time before/after self-admin3.03.34.6-2.01.81.81.61.9-2.12.12.0-2.00.51.5
Parametrial fat weight0.20.41.61.3-0.5-0.5-0.6-0.50.3-0.2-0.10.2-1.10.3
Pavlov. Cond. lever latency3.03.85.3-1.61.91.91.91.8-1.82.02.1-2.12.32.1
Pavlov. Cond. magazine entry latency2.32.93.71.8-1.9-1.8-1.9-1.81.7-1.7-1.61.7-1.8-0.7
Pavlov. Cond. change in total contacts2.62.84.31.8-1.8-1.7-1.8-1.71.6-1.7-1.61.6-2.1-1.0
Pavlov. Cond. index score1.92.43.91.5-1.6-1.5-1.7-1.51.4-1.5-1.51.5-2.0-1.0
Pavlov. Cond. latency score1.51.93.61.2-1.4-1.4-1.5-1.41.3-1.4-1.41.4-1.9-0.9
Pavlov. Cond. lever contacts3.23.74.51.6-2.1-2.0-2.1-2.01.8-2.0-2.02.0-2.1-1.3
Pavlov. Cond. magazine entry number2.12.63.7-1.61.81.71.91.8-1.61.61.5-1.51.90.1
Pavlov. Cond. intertrial magazine entries0.40.40.70.4-0.7-0.7-0.6-0.70.8-0.7-0.80.8-0.2-0.4
Pavlov. Cond. lever-magazine prob. diff.2.43.03.91.7-1.8-1.8-1.9-1.81.7-1.7-1.61.6-2.0-1.1
Pavlov. Cond. response bias3.54.25.32.1-2.2-2.2-2.3-2.12.0-2.0-1.92.0-2.3-1.3
Pavlov. Cond. lever latency0.71.04.6-1.40.50.50.40.3-0.40.70.6-0.61.32.1
Pavlov. Cond. magazine entry latency3.74.39.22.1-1.9-2.0-1.9-1.92.0-2.1-2.02.1-1.6-3.0
Pavlov. Cond. change in total contacts0.81.28.70.9-0.4-0.4-0.3-0.20.3-0.7-0.60.6-1.3-2.9
Pavlov. Cond. index score2.22.88.12.1-1.4-1.4-1.3-1.31.3-1.6-1.51.6-1.7-2.9
Pavlov. Cond. latency score2.43.07.71.9-1.5-1.5-1.4-1.41.5-1.7-1.61.7-1.6-2.8
Pavlov. Cond. lever contacts0.81.17.21.3-0.5-0.5-0.4-0.30.4-0.7-0.60.6-1.1-2.7
Pavlov. Cond. magazine entry number2.73.310.9-1.81.51.51.41.4-1.61.81.7-1.71.63.3
Pavlov. Cond. intertrial magazine entries2.83.711.8-0.91.81.81.71.7-1.91.91.9-1.91.23.4
Pavlov. Cond. lever-magazine prob. diff.2.63.310.02.1-1.5-1.5-1.4-1.31.4-1.7-1.61.7-1.7-3.2
Pavlov. Cond. response bias1.41.99.81.9-0.8-0.8-0.7-0.60.7-1.0-0.91.0-1.6-3.1
Time in closed arm before self-admin2.42.73.51.8-1.8-1.9-1.8-1.91.8-1.7-1.71.7-0.8-0.4
Time in closed arm after self-admin0.30.31.80.8-0.3-0.2-0.3-0.20.1-0.2-0.30.3-1.4-0.1
Time in open arm before self-admin0.10.10.1-0.0-0.3-0.3-0.2-0.30.3-0.3-0.20.10.30.1
Time in open arm after self-admin0.50.54.9-0.40.1-0.10.2-0.10.3-0.3-0.10.12.2-0.4
Bone: periosteal estimation2.65.37.2-2.72.62.52.72.6-2.22.22.1-2.22.4-0.4
Bone: periosteal perimeter2.84.76.7-1.92.52.52.62.6-2.42.22.2-2.21.40.1
Bone: post-yield work0.70.92.3-1.01.00.91.00.9-0.80.90.9-0.91.50.7
Progressive ratio test 1 active lever presses0.10.10.70.50.10.10.00.1-0.20.10.2-0.2-0.80.3
Progressive ratio test 1 breakpoint0.10.10.70.6-0.3-0.2-0.3-0.20.1-0.1-0.10.0-0.90.1
Progressive ratio test 1 inactive lever presses0.10.10.7-0.80.20.20.30.20.1-0.00.0-0.20.3-0.4
Progressive ratio test 2 active lever presses0.30.32.2-0.90.30.20.40.2-0.10.30.3-0.51.5-0.0
Progressive ratio test 2 breakpoint0.30.31.1-0.90.40.30.40.3-0.20.30.4-0.61.10.0
Progressive ratio test 2 inactive lever presses0.20.21.4-1.20.0-0.00.1-0.00.2-0.1-0.1-0.11.0-0.1
Incentive Sensitization - Responses1.21.26.8-1.70.70.60.90.6-0.50.70.6-0.92.60.0
Incentive Sensitization - Breakpoint1.31.36.7-1.70.80.71.00.7-0.60.80.7-1.02.60.1
Sum of active levers in priming session hrs 5-60.20.21.2-0.50.10.00.20.00.3-0.3-0.30.30.6-1.1
Progressive ratio0.10.20.70.6-0.2-0.2-0.2-0.20.3-0.1-0.2-0.0-0.7-0.8
Food seeking constrained by brief footshock0.60.71.2-0.40.91.00.81.0-1.11.00.9-0.8-0.60.2
Seeking ratio, punishment vs. effort0.30.30.7-0.80.60.60.60.6-0.70.50.5-0.30.40.5
Retroperitoneal fat weight0.82.63.8-0.81.71.81.51.9-2.02.01.9-1.8-1.20.3
Reaction time number correct1.11.62.30.5-1.4-1.4-1.4-1.41.3-1.5-1.41.5-0.9-0.9
Reaction time mean minus median0.50.73.5-0.40.60.70.50.5-0.60.80.8-0.80.41.9
Reaction time mean minus median AUC0.91.23.3-0.61.01.01.00.8-0.91.01.1-1.01.21.8
Reaction time num false alarms0.00.00.10.00.20.20.20.2-0.2-0.00.00.1-0.2-0.1
Reaction time num false alarms AUC0.00.00.10.10.30.30.30.3-0.20.00.00.2-0.3-0.1
Reaction time trials correct on left1.11.62.30.5-1.4-1.4-1.4-1.41.3-1.5-1.41.5-0.9-0.9
Reaction time trials on left1.21.72.50.5-1.4-1.4-1.4-1.41.3-1.5-1.51.6-1.0-0.9
Reaction time mean0.10.21.21.1-0.2-0.2-0.3-0.20.0-0.1-0.10.1-0.60.6
Reaction time mean AUC0.20.21.61.3-0.2-0.2-0.3-0.20.0-0.1-0.10.1-0.50.6
Median of all reaction times0.20.31.81.3-0.5-0.5-0.5-0.50.3-0.4-0.40.3-0.70.0
Reaction time omissions0.30.41.51.2-0.4-0.4-0.5-0.50.5-0.6-0.60.7-0.80.3
Reaction time false alarm rate0.30.40.7-0.00.80.80.80.8-0.70.60.7-0.60.20.6
Reaction time premature initiation rate0.40.64.4-1.30.10.10.20.2-0.00.0-0.0-0.20.3-2.1
Reaction time premature initiations0.50.74.3-1.1-0.5-0.5-0.4-0.40.5-0.5-0.60.4-0.2-2.1
Std. dev. reaction times0.30.41.20.50.50.60.40.5-0.70.60.5-0.5-0.91.1
Reaction time trials completed1.21.72.50.5-1.4-1.4-1.4-1.41.3-1.5-1.51.6-1.0-0.9
Reaction time trials AUC0.91.31.90.4-1.2-1.2-1.2-1.21.1-1.3-1.31.4-0.9-1.0
Run reversals in cocaine runway, females2.22.25.12.3-1.5-1.4-1.6-1.31.0-1.1-1.01.2-2.1-1.1
Run reversals in cocaine runway, males1.21.11.6-0.61.11.11.11.1-1.11.21.2-1.30.80.8
Latency to leave start box in cocaine runway0.60.72.9-0.50.70.70.80.6-0.60.70.6-0.71.70.8
Latency to leave start box in cocaine runway, F0.30.33.2-0.5-0.1-0.20.1-0.20.3-0.2-0.30.01.8-0.2
Latency to leave start box in cocaine runway, M1.41.41.7-1.01.21.21.21.2-1.21.21.1-1.10.81.3
Std. dev. time between licks in bursts1.21.42.91.7-0.9-0.9-0.9-0.80.8-1.1-1.11.0-1.7-1.6
Total sessions with >9 infusions0.50.51.21.10.70.80.70.8-0.70.60.7-0.7-0.80.0
Short access day 1 total inactive lever presses2.12.43.4-0.91.81.81.81.8-1.71.51.5-1.41.50.9
Short access day 10 total inactive lever presses3.43.88.3-2.91.91.81.91.8-1.81.81.7-1.72.41.2
Short access day 1 total infusions1.01.11.6-0.51.21.21.31.3-1.11.11.1-1.20.6-0.3
Short access day 10 total infusions0.10.10.7-0.2-0.1-0.1-0.1-0.00.1-0.2-0.20.2-0.80.0
Short access total infusions0.70.81.4-0.21.11.11.11.2-1.10.90.9-1.00.30.1
Short access day 1 locomotion0.20.31.31.1-0.1-0.10.1-0.10.4-0.5-0.40.30.3-0.9
Short access day 10 total locomotion0.91.01.70.5-0.9-1.0-0.8-1.01.3-1.3-1.31.2-0.6-1.0
Short access total locomotion0.20.20.90.70.00.10.10.10.2-0.3-0.40.4-1.0-0.5
One hour access (0.3 mA shock)0.40.41.5-0.5-0.4-0.5-0.3-0.50.7-0.7-0.60.51.2-0.6
Compulsive drug intake0.60.61.4-1.2-0.5-0.5-0.3-0.50.9-0.9-0.70.90.7-0.9
One hour access (shock baseline)0.20.20.50.7-0.4-0.5-0.4-0.50.5-0.4-0.40.20.6-0.1
Social response proportion0.20.20.60.60.40.40.30.4-0.40.60.5-0.5-0.10.8
Social responses0.70.94.31.4-0.4-0.3-0.4-0.20.3-0.3-0.40.5-2.1-1.5
Social time3.24.310.83.3-1.9-1.8-1.9-1.82.0-1.8-2.01.9-2.4-1.4
Soleus weight0.30.84.4-1.40.50.40.50.3-0.30.50.6-0.62.10.6
Bone: stiffness0.81.31.9-0.81.41.41.41.4-1.21.21.1-1.10.70.4
Tibialis anterior weight0.41.23.40.7-1.1-1.1-1.1-1.21.3-1.0-0.91.0-0.31.9
Time to tail flick, vehicle, before self-admin0.20.20.5-0.30.30.40.30.4-0.40.40.4-0.3-0.70.3
Time to tail flick, vehicle, after self-admin0.40.40.70.0-0.5-0.6-0.4-0.60.8-0.8-0.80.70.1-0.8
Time to tail flick, test, before self-admin0.10.00.2-0.10.20.20.20.2-0.30.10.3-0.10.20.5
Time to tail flick, test, after self-admin2.62.73.81.5-1.6-1.7-1.5-1.72.0-1.9-1.91.9-0.3-1.5
Delta time to tail flick, vehicle, before/after SA0.30.32.1-0.40.1-0.00.2-0.10.3-0.4-0.10.11.4-0.8
Delta time to tail flick, test, before/after SA2.82.54.01.0-1.6-1.7-1.4-1.72.0-1.8-1.91.7-0.1-1.8
Tibia length0.82.23.2-1.81.61.71.61.8-1.61.51.6-1.50.5-0.1
Ambulatory time before self-admin0.50.54.32.1-0.0-0.10.1-0.10.2-0.2-0.20.00.6-1.0
Ambulatory time after self-admin0.20.20.60.40.40.30.40.3-0.40.50.4-0.50.80.0
Bone: tissue strength0.50.40.9-0.80.70.70.80.7-0.50.40.5-0.40.6-1.0
Total heroin consumption0.40.50.8-0.90.70.70.80.7-0.60.50.7-0.70.90.0
Bone: trabecular number0.10.10.30.1-0.4-0.4-0.3-0.40.3-0.3-0.30.20.3-0.6
Bone: trabecular spacing0.50.71.0-0.01.01.01.01.0-0.90.90.9-0.80.10.6
Bone: trabecular thickness0.60.82.21.5-0.7-0.7-0.8-0.60.3-0.6-0.60.6-1.5-0.9
Bone: trabecular tissue density0.60.81.10.4-0.9-0.9-1.0-0.91.1-1.0-1.01.0-1.0-0.0
Water consumed over 24 hours5.05.97.9-2.52.32.32.32.2-2.42.52.5-2.42.82.6
Number of responses in last shaping day0.70.81.01.0-0.9-0.9-1.0-0.90.9-0.9-0.90.7-0.9-0.4