Hub : Genes

Tspo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Tspo 0.19 0.15 3.0e-04 0.07 0.06 0.06 0.06 5.4e-04 1.5e-03 1.4e-03 1.0e-03
2 NAcc gene expression Tspo 0.06 0.04 5.8e-13 0.07 0.08 0.07 0.08 2.3e-10 2.9e-12 1.6e-11 1.3e-11
3 BLA gene expression Tspo 0.1 0.08 9.8e-06 0.08 0.08 0.07 0.08 5.1e-05 3.3e-05 1.2e-04 6.4e-05
4 Adipose gene expression Tspo 0.37 0.16 0.0e+00 0.2 0.19 0.2 0.2 7.4e-22 4.9e-21 6.5e-22 4.8e-22
5 PL gene expression Tspo 0.08 0.06 5.6e-10 0.09 0.07 0.06 0.08 1.1e-09 5.1e-08 4.5e-07 8.2e-09
6 pVTA gene expression Tspo 0.19 0.12 1.3e-09 0.13 0.12 0.12 0.12 1.2e-10 1.6e-09 1.0e-09 1.3e-09
7 Liver gene expression Tspo 0.87 0.02 0.0e+00 0.12 0.23 0.21 0.13 4.1e-13 1.2e-25 8.7e-23 1.4e-14
8 Brain gene expression Tspo 0.11 0.07 3.2e-12 0.13 0.12 0.14 0.13 7.0e-12 1.3e-11 5.0e-13 4.8e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.61.1-1.1-0.8-0.7-0.8-0.7-0.7-0.8-0.8
Area under the delay curve1.31.61.9-1.1-1.4-1.4-1.4-1.3-1.3-0.8-1.3
BMI with tail1.34.65.91.62.32.32.42.42.41.91.7
BMI without tail0.72.16.30.81.11.01.51.41.42.51.1
Body weight1.66.88.82.62.42.43.02.82.82.12.7
Weight adjusted by age0.10.10.30.10.30.30.40.30.50.20.2
Bone surface0.20.42.9-0.4-0.2-0.2-0.2-0.2-0.1-1.7-0.0
Bone volume0.10.21.3-0.4-0.2-0.2-0.2-0.2-0.2-1.2-0.1
Breakpoint value in progressive ratio session0.40.51.60.40.20.10.70.70.50.91.3
Number of licking bursts0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.30.5-0.2
Context. condit. distance diff. score4.95.97.92.72.82.82.52.52.61.61.7
Locomotion velocity, session 10.80.91.70.71.01.00.80.80.8-1.31.1
Locomotion distance, session 10.50.71.5-1.2-0.5-0.4-0.8-0.7-0.8-1.1-0.7
Locomotion velocity, session 20.91.01.70.71.11.10.91.11.0-1.30.7
Locomotion distance, session 21.41.93.0-1.7-1.2-1.1-1.4-1.2-1.3-1.6-1.3
Locomotion velocity, session 30.70.71.90.30.91.00.70.90.8-1.40.4
Locomotion distance, session 31.11.22.2-1.3-0.9-0.9-1.1-1.0-0.9-0.9-1.5
Stereotopy head waving bouts, day 30.70.81.00.80.90.91.00.90.9-0.90.9
Stereotopy head waving duration, day 34.14.96.62.22.42.42.62.52.4-0.02.1
Locomotion velocity, session 70.10.20.7-0.30.20.20.10.20.3-0.9-0.5
Locomotion distance, session 71.11.42.4-1.5-1.0-0.9-1.3-1.0-0.7-1.5-1.2
Stereotopy head waving bouts, day 73.33.85.22.12.32.32.12.12.0-0.21.6
Stereotopy head waving duration, day 72.83.34.42.02.12.12.12.01.90.31.4
Locomotion velocity, session 85.76.99.02.83.03.02.72.92.71.22.3
Locomotion distance, session 80.91.32.11.11.41.51.11.21.30.30.8
Degree of sensitization distance0.80.81.31.00.90.90.90.91.00.31.1
Degree of sensitization stereotypy3.13.34.62.02.12.21.92.01.90.51.5
Conditioned locomotion0.10.10.20.40.20.10.30.30.20.50.2
Cocaine response after cond. corrected0.00.00.10.10.20.20.0-0.1-0.0-0.3-0.3
Cocaine response after cond. not corrected0.10.10.30.20.30.30.0-0.1-0.1-0.6-0.3
Cocaine response before conditioning0.10.10.2-0.2-0.3-0.3-0.3-0.3-0.4-0.50.0
Saline control response0.40.51.40.60.50.50.80.70.50.31.2
Bone: connectivity density0.10.20.6-0.6-0.4-0.4-0.3-0.1-0.1-0.7-0.4
Bone: cortical apparent density1.62.32.7-1.4-1.6-1.6-1.6-1.6-1.6-0.9-1.4
Bone: cortical area1.32.03.01.71.51.41.61.51.50.51.4
Bone: cortical porosity0.10.10.30.40.40.40.20.40.6-0.3-0.1
Bone: cortical porosity0.91.01.61.31.11.20.91.11.2-0.20.7
Bone: cortical thickness0.20.31.60.6-0.1-0.10.50.40.31.30.4
Bone: cortical thickness0.80.93.51.00.60.50.80.60.71.90.9
Bone: cortical tissue density1.52.02.4-1.3-1.5-1.5-1.5-1.6-1.5-0.9-1.4
Condit. Reinf. active minus inactive responses1.82.04.5-0.9-1.3-1.3-1.3-1.4-1.4-2.1-1.4
Condit. Reinf. active-inactive response ratio0.20.21.70.30.10.10.10.00.0-1.3-0.1
Condit. Reinf. active responses3.84.85.8-1.8-2.1-2.1-2.2-2.3-2.3-2.2-2.4
Condit. Reinf. inactive responses3.34.15.1-2.3-2.2-2.1-2.1-2.1-2.2-1.0-1.8
Incentive salience index mean2.53.15.2-1.4-1.8-1.7-1.7-1.7-1.8-2.3-1.7
Condit. Reinf. lever presses2.63.66.8-1.7-1.9-1.8-1.8-1.9-1.9-2.6-1.5
Condit. Reinf. active minus inactive responses0.10.20.80.30.10.10.10.10.1-0.90.8
Condit. Reinf. active-inactive response ratio0.20.21.20.30.10.20.20.20.1-1.10.8
Condit. Reinf. active responses0.71.02.31.10.90.90.80.80.8-1.01.5
Condit. Reinf. inactive responses0.70.81.11.01.01.10.80.91.0-0.41.1
Condit. Reinf. lever presses0.60.84.2-0.3-0.4-0.3-0.8-0.7-0.7-2.0-0.2
Condit. Reinf. lever reinforcers received0.40.62.70.60.40.40.20.20.3-1.61.1
Conditioned reinforcement - actives0.10.21.20.5-0.1-0.1-0.3-0.3-0.2-1.1-0.4
Conditioned reinforcement - inactives0.10.20.50.30.40.30.30.30.50.7-0.0
Conditioned locomotion0.30.40.80.90.70.70.60.60.60.10.5
Patch foraging indifference point 0 sec0.10.20.4-0.4-0.4-0.4-0.4-0.3-0.3-0.6-0.5
Patch foraging indifference point AUC0.50.72.5-0.6-0.6-0.6-0.8-0.6-0.7-1.6-0.7
Delay disc. indifference point, 0s delay0.30.30.60.60.60.60.60.80.80.30.1
Delay disc. indifference point, 16s delay2.83.03.6-1.4-1.8-1.8-1.9-1.8-1.9-1.5-1.7
Delay disc. indifference point, 2s delay0.40.40.8-0.9-0.8-0.8-0.7-0.5-0.6-0.2-0.8
Delay disc. indifference point, 24s delay0.50.60.9-0.7-0.9-0.8-0.8-0.8-0.9-0.4-0.5
Delay disc. indifference point, 4s delay0.20.30.9-0.4-0.3-0.2-0.5-0.4-0.3-0.7-1.0
Delay disc. indifference point, 8s delay2.12.43.0-1.5-1.7-1.7-1.7-1.7-1.7-0.6-1.5
Indifference point function ln k1.22.24.31.11.21.21.51.41.52.11.5
Indifference point function log k1.22.24.31.11.21.21.51.41.52.11.5
Patch foraging total patch changes 0 sec0.10.20.3-0.5-0.5-0.5-0.4-0.3-0.3-0.4-0.5
Patch foraging total patch changes 12 sec0.50.75.00.10.30.30.10.20.1-2.20.3
Patch foraging total patch changes 18 sec0.10.10.4-0.1-0.3-0.3-0.2-0.0-0.0-0.70.2
Patch foraging total patch changes 24 sec0.30.52.5-0.5-0.4-0.4-0.5-0.3-0.4-1.6-0.6
Patch foraging total patch changes 6 sec0.10.10.70.20.00.00.00.1-0.0-0.80.2
Patch foraging time to switch 0 sec0.51.14.0-0.7-0.7-0.6-1.0-1.0-1.0-2.0-0.7
Patch foraging water rate 0 sec0.71.43.71.01.11.01.21.21.21.90.4
Patch foraging water rate 12 sec0.30.71.5-0.00.70.71.01.00.91.20.5
Patch foraging water rate 18 sec0.00.00.1-0.2-0.1-0.0-0.1-0.1-0.2-0.4-0.1
Patch foraging water rate 24 sec2.23.04.71.51.51.42.12.01.61.52.2
Patch foraging water rate 6 sec0.10.20.6-0.8-0.5-0.5-0.3-0.2-0.2-0.4-0.3
Seeking ratio, delayed vs. immediate footshock2.32.95.7-2.4-1.8-1.8-1.7-1.6-1.4-1.2-1.4
Distance traveled before self-admin0.30.40.7-0.8-0.6-0.6-0.7-0.7-0.6-0.6-0.6
Distance traveled after self-admin0.00.00.10.2-0.0-0.10.20.20.20.10.4
Extensor digitorum longus weight0.10.31.90.10.20.20.20.20.31.4-0.2
Bone: elastic displacement1.21.41.91.31.41.41.11.21.30.41.1
Bone: elastic work3.95.16.72.42.62.62.32.32.40.72.1
Bone: endosteal estimation1.53.36.31.62.42.51.51.71.7-1.71.1
Bone: endosteal perimeter1.32.84.71.72.12.21.61.61.7-1.01.3
Epididymis fat weight0.93.04.02.01.61.61.91.81.9-0.52.0
Delta time in closed arm before/after self-admin0.70.62.0-0.2-0.4-0.4-0.8-0.8-0.6-1.1-1.4
Delta time in open arm before/after self-admin0.40.40.90.30.90.90.70.70.60.10.4
Diff in mean of infusions in LGA sessions0.10.10.30.50.10.10.20.10.3-0.10.4
Delay discount exponential model param1.31.51.81.11.31.31.31.21.30.81.2
Extinction: sum of active levers before priming0.20.20.91.00.50.50.20.20.2-0.50.1
Active lever presses in extinction session 60.70.71.00.80.80.70.91.00.81.00.9
Bone: final force0.61.01.41.21.21.21.11.00.90.10.9
Bone: final moment1.01.62.21.51.51.51.41.31.20.21.1
Food consumed during 24 hour testing period2.02.83.41.61.81.81.81.71.61.51.5
Glucose0.30.41.2-0.7-0.8-0.8-0.4-0.3-0.60.1-1.1
Heart weight9.114.119.44.43.83.84.03.83.73.23.2
Delay discount hyperbolic model param1.11.21.41.01.21.21.21.11.10.71.2
Intermittent access intake day 1-15 change0.40.81.1-0.8-1.0-1.0-0.8-0.9-1.0-0.5-1.0
Intermittent access intake escalation0.51.11.3-0.9-1.1-1.1-1.0-1.1-1.2-0.7-1.2
Intermittent access intake escalation 21.31.51.9-1.2-1.3-1.3-1.2-1.3-1.3-1.0-1.4
Intermitt. access day 1 inactive lever presses0.10.50.70.80.60.60.70.70.70.70.7
Intermitt. access day 15 inactive lever presses0.00.10.30.50.20.2-0.2-0.1-0.2-0.1-0.1
Intermitt. access escalation Index0.20.30.5-0.6-0.7-0.7-0.6-0.6-0.7-0.1-0.4
Intermittent access day 1 total infusions0.30.40.80.70.80.90.60.60.90.30.1
Intermittent access day 15 total infusions0.20.30.8-0.5-0.4-0.4-0.5-0.5-0.4-0.3-0.9
Intermittent access terminal intake (last 3 days)0.50.62.2-0.6-0.4-0.4-0.6-0.6-0.4-1.1-1.5
Intermittent access total infusions0.10.10.6-0.10.20.3-0.1-0.10.2-0.4-0.8
Intermittent access day 1 locomotion0.00.00.10.1-0.1-0.1-0.0-0.00.10.3-0.3
Intermittent access day 15 total locomotion0.00.10.20.00.30.30.20.10.20.2-0.5
Intermittent access total locomotion0.10.10.4-0.00.40.40.10.10.3-0.1-0.7
Intermittent access standard deviation0.00.10.3-0.00.10.10.10.10.1-0.2-0.6
Left kidney weight12.859.571.48.48.38.28.38.28.13.47.4
Right kidney weight13.863.073.08.48.58.58.58.58.34.27.5
Cocaine induced anxiety1.21.72.21.21.41.31.41.41.30.91.5
Post-drug Anxiety0.40.41.10.20.30.30.70.70.51.10.7
Baseline Anxiety1.51.72.9-1.6-1.7-1.7-1.2-1.2-1.20.0-1.2
Tail length0.10.41.5-0.3-0.7-0.8-0.1-0.2-0.31.2-0.1
Length with tail0.41.52.61.61.01.01.41.31.20.91.3
Length without tail1.03.15.52.31.81.81.91.81.7-0.61.7
Times rat made contact with spout2.32.76.61.01.31.31.71.71.62.61.4
Lifetime Intake0.10.20.40.40.60.60.30.20.4-0.2-0.3
Liver weight, left0.20.41.40.50.10.10.50.30.11.11.2
Liver weight, right0.61.12.31.50.90.81.00.80.90.81.4
Locomotor activity2.23.45.42.32.12.11.91.91.90.01.3
Locomotor testing distance0.30.51.7-0.4-0.2-0.2-0.6-0.6-0.6-1.3-1.0
Locomotor testing rearing0.20.40.90.90.80.80.50.40.4-0.60.2
Locomotion in novel chamber0.10.10.3-0.1-0.5-0.6-0.2-0.3-0.2-0.4-0.2
Locomotion in novel chamber post-restriction0.81.32.1-1.5-1.1-1.1-1.2-1.2-1.2-0.9-1.0
Fecal boli incidents, locomotor time 10.10.10.2-0.4-0.1-0.1-0.4-0.3-0.4-0.5-0.2
Change in fecal boli incidents, locomotor task1.21.22.11.00.90.91.21.00.91.01.4
Time >=10cm from walls, locomotor time 10.30.32.30.00.20.3-0.2-0.3-0.1-1.5-0.3
Bouts of movement, locomotor time 10.10.10.1-0.3-0.3-0.3-0.2-0.2-0.20.1-0.4
Total resting periods, locomotor time 10.20.20.3-0.6-0.5-0.5-0.4-0.4-0.40.1-0.5
Rest time, locomotor task time 10.00.00.1-0.10.10.10.20.10.30.30.2
Distance moved, locomotor task time 10.10.10.30.50.30.30.30.30.4-0.40.5
Vertical activity count, locomotor time 10.00.00.20.20.10.10.10.10.1-0.50.2
Time >=10cm from walls, locomotor time 20.40.50.7-0.7-0.7-0.7-0.7-0.8-0.7-0.7-0.7
Bouts of movement, locomotor time 20.20.20.4-0.3-0.6-0.6-0.6-0.5-0.4-0.2-0.6
Total resting periods, locomotor time 20.10.20.4-0.3-0.6-0.6-0.6-0.4-0.30.0-0.5
Rest time, locomotor task time 20.10.10.2-0.3-0.4-0.5-0.2-0.1-0.20.40.1
Distance moved, locomotor task time 20.50.60.90.80.90.90.80.80.90.30.5
Vertical activity count, locomotor time 20.30.40.60.70.70.70.80.70.60.30.6
Light reinforcement 10.20.40.80.40.80.90.40.50.6-0.80.7
Light reinforcement 20.40.51.40.20.70.70.80.70.9-0.11.2
Bone: marrow area1.73.76.91.72.52.61.61.81.8-1.71.2
Bone: maximum diameter4.48.110.73.13.23.33.13.03.00.62.5
Bone: maximum force1.62.83.61.81.91.91.81.81.70.71.5
Bone: maximum moment2.23.95.02.22.22.22.12.12.00.91.7
Mean time between licks in bursts0.51.11.8-0.9-1.1-1.1-1.2-1.3-1.20.1-1.3
Mean num. licks in bursts1.52.32.91.31.51.51.71.71.61.51.4
Cd content in liver1.41.64.01.41.11.11.11.01.02.01.1
Co content in liver1.21.39.00.60.40.30.60.50.53.00.5
Cu content in liver6.88.09.3-2.9-3.0-3.0-3.0-3.0-3.0-2.4-2.2
Fe content in liver1.92.32.91.51.71.71.61.61.5-1.01.5
K content in liver1.81.74.2-1.3-1.3-1.3-1.2-1.2-1.1-2.0-0.7
Mg content in liver2.42.56.4-1.5-1.5-1.4-1.5-1.4-1.3-2.5-0.9
Mn content in liver0.10.10.2-0.2-0.2-0.2-0.1-0.1-0.2-0.40.4
Na content in liver1.51.62.6-1.6-1.3-1.3-1.2-1.1-1.1-1.1-1.4
Rb content in liver0.20.20.40.70.50.50.30.20.5-0.60.4
Se content in liver1.41.64.5-1.1-1.1-1.0-1.2-1.2-1.2-2.1-0.8
Sr content in liver2.42.13.2-1.4-1.5-1.6-1.3-1.3-1.41.2-1.8
Zn content in liver0.00.00.0-0.2-0.1-0.1-0.1-0.2-0.1-0.2-0.0
Bone: minimum diameter0.40.70.91.00.91.00.70.70.6-0.70.8
Time in familiar zone, hab. session 10.10.10.30.10.50.50.40.30.30.10.3
Time in novel zone, hab. session 11.11.12.21.50.90.91.01.01.11.40.6
Total zone transitions, hab. session 11.82.53.7-1.9-1.7-1.7-1.6-1.7-1.7-1.1-1.1
Total locomotion distance, hab. session 10.50.71.4-1.1-0.8-0.8-0.7-0.8-0.8-1.2-0.1
Locomotion velocity, hab. session 10.81.12.3-1.4-1.0-1.0-0.9-1.0-1.0-1.5-0.3
Time in familiar zone, hab. session 20.10.10.5-0.2-0.4-0.4-0.2-0.4-0.20.7-0.1
Time in novel zone, hab. session 20.80.81.21.00.90.91.01.10.90.40.5
Total zone transitions, hab. session 20.30.42.3-0.6-0.1-0.1-0.3-0.2-0.2-1.5-0.3
Total locomotion distance, hab. session 20.20.20.5-0.7-0.4-0.4-0.4-0.4-0.5-0.7-0.3
Locomotion velocity, hab. session 20.50.61.1-1.1-0.7-0.7-0.7-0.7-0.8-1.0-0.4
Novel to familiar place preference ratio3.63.97.02.41.71.71.91.81.72.61.7
Novelty place preference4.65.08.72.72.01.92.22.12.03.01.9
Time in novel zone, NPP test6.16.510.03.02.32.32.52.42.33.22.2
Total zone transitions, NPP test0.71.11.5-1.2-0.8-0.8-1.1-1.1-1.2-0.9-1.1
Total locomotion distance, NPP test0.30.50.6-0.8-0.5-0.5-0.7-0.7-0.8-0.7-0.8
Locomotion velocity, NPP test1.41.92.4-1.5-1.2-1.2-1.4-1.4-1.6-1.2-1.4
Intraocular pressure0.40.50.90.40.70.70.80.90.90.80.5
Delta distance traveled before/after self-admin1.92.02.31.51.31.31.51.51.51.01.5
Delta ambulatory time before/after self-admin2.83.45.01.91.61.52.02.01.91.52.2
Parametrial fat weight0.40.81.8-0.9-1.3-1.3-0.8-0.9-0.80.3-0.6
Pavlov. Cond. lever latency2.12.63.81.41.71.61.61.71.71.91.1
Pavlov. Cond. magazine entry latency1.72.23.4-1.4-1.8-1.8-1.6-1.5-1.5-0.5-1.2
Pavlov. Cond. change in total contacts2.12.23.2-1.4-1.8-1.8-1.6-1.6-1.6-1.1-1.0
Pavlov. Cond. index score1.62.12.8-1.3-1.7-1.7-1.5-1.5-1.4-1.2-1.2
Pavlov. Cond. latency score1.41.72.3-1.1-1.5-1.5-1.4-1.4-1.4-1.2-1.1
Pavlov. Cond. lever contacts3.84.55.4-2.1-2.3-2.3-2.2-2.2-2.2-1.8-1.7
Pavlov. Cond. magazine entry number2.02.53.91.51.92.01.71.61.60.41.4
Pavlov. Cond. intertrial magazine entries0.50.61.5-0.6-0.7-0.6-0.7-0.8-0.8-0.5-1.2
Pavlov. Cond. lever-magazine prob. diff.2.12.63.5-1.5-1.9-1.9-1.7-1.6-1.6-1.3-1.3
Pavlov. Cond. response bias3.44.25.8-2.0-2.4-2.4-2.2-2.1-2.1-1.5-1.6
Pavlov. Cond. lever latency0.60.85.00.40.50.40.70.60.52.20.2
Pavlov. Cond. magazine entry latency3.23.87.5-1.9-1.8-1.7-1.9-1.9-1.8-2.7-1.7
Pavlov. Cond. change in total contacts0.61.07.1-0.3-0.3-0.3-0.6-0.6-0.5-2.70.1
Pavlov. Cond. index score1.72.36.7-1.2-1.3-1.2-1.4-1.4-1.3-2.6-1.0
Pavlov. Cond. latency score2.02.66.5-1.4-1.4-1.4-1.6-1.5-1.5-2.6-1.1
Pavlov. Cond. lever contacts0.81.16.4-0.6-0.6-0.5-0.8-0.8-0.6-2.5-0.3
Pavlov. Cond. magazine entry number2.63.29.21.51.51.41.71.71.63.01.2
Pavlov. Cond. intertrial magazine entries2.74.110.02.01.81.71.81.91.93.21.5
Pavlov. Cond. lever-magazine prob. diff.2.02.78.1-1.4-1.4-1.3-1.5-1.5-1.5-2.9-1.0
Pavlov. Cond. response bias1.31.78.2-0.8-0.9-0.8-1.1-1.0-0.9-2.9-0.7
Time in closed arm before self-admin2.73.45.1-2.3-2.1-2.1-2.0-2.0-2.0-0.6-1.1
Time in closed arm after self-admin1.11.11.8-0.9-1.3-1.3-1.1-1.1-1.3-0.5-0.8
Time in open arm before self-admin0.10.10.6-0.4-0.3-0.3-0.4-0.3-0.10.2-0.8
Time in open arm after self-admin0.20.20.60.10.80.80.40.40.60.2-0.2
Bone: periosteal estimation1.73.65.72.12.32.41.91.91.9-0.91.6
Bone: periosteal perimeter2.74.66.02.42.42.52.32.22.2-0.22.1
Bone: post-yield work0.40.60.80.60.90.90.90.90.80.90.4
Progressive ratio test 1 active lever presses0.00.10.10.20.20.20.20.20.30.4-0.0
Progressive ratio test 1 breakpoint0.00.00.10.10.00.10.00.00.10.3-0.2
Progressive ratio test 1 inactive lever presses0.10.20.30.50.50.60.30.30.50.3-0.2
Progressive ratio test 2 active lever presses0.20.20.60.20.50.60.30.30.70.1-0.4
Progressive ratio test 2 breakpoint0.10.10.40.10.40.50.20.20.60.0-0.6
Progressive ratio test 2 inactive lever presses0.20.30.7-0.7-0.4-0.4-0.5-0.5-0.20.2-0.8
Incentive Sensitization - Responses0.20.30.60.10.70.80.40.40.80.2-0.4
Incentive Sensitization - Breakpoint0.20.30.70.20.80.80.50.50.80.2-0.4
Sum of active levers in priming session hrs 5-60.10.10.70.20.30.3-0.0-0.1-0.1-0.80.0
Progressive ratio0.10.10.4-0.0-0.4-0.4-0.3-0.2-0.2-0.6-0.1
Food seeking constrained by brief footshock0.81.02.41.10.80.81.01.00.90.21.6
Seeking ratio, punishment vs. effort0.20.30.50.40.60.60.60.50.40.50.7
Retroperitoneal fat weight2.08.412.63.52.72.73.23.03.10.93.3
Reaction time number correct0.91.72.2-1.5-1.4-1.4-1.4-1.3-1.4-0.7-0.9
Reaction time mean minus median0.41.04.11.00.60.50.90.70.82.00.6
Reaction time mean minus median AUC0.61.44.11.21.01.01.21.11.02.00.6
Reaction time num false alarms0.10.10.60.30.30.30.10.1-0.1-0.20.8
Reaction time num false alarms AUC0.10.10.30.30.30.30.10.1-0.0-0.30.6
Reaction time trials correct on left0.91.72.2-1.5-1.4-1.4-1.4-1.3-1.4-0.7-0.9
Reaction time trials on left0.91.82.2-1.5-1.5-1.5-1.4-1.4-1.5-0.8-0.9
Reaction time mean0.10.10.80.0-0.2-0.30.0-0.1-0.20.90.1
Reaction time mean AUC0.10.10.9-0.1-0.2-0.3-0.0-0.1-0.20.90.1
Median of all reaction times0.10.20.3-0.4-0.5-0.5-0.4-0.4-0.50.3-0.2
Reaction time omissions0.10.10.20.3-0.1-0.2-0.2-0.3-0.50.4-0.1
Reaction time false alarm rate0.40.60.91.00.90.90.70.70.60.40.9
Reaction time premature initiation rate0.40.64.7-0.10.10.1-0.0-0.2-0.1-2.20.1
Reaction time premature initiations0.50.84.1-0.7-0.6-0.5-0.6-0.6-0.6-2.0-0.3
Std. dev. reaction times0.40.71.71.20.50.40.70.60.41.30.9
Reaction time trials completed0.91.82.2-1.5-1.5-1.5-1.4-1.4-1.5-0.8-0.9
Reaction time trials AUC0.71.41.8-1.3-1.3-1.3-1.2-1.2-1.3-0.8-0.7
Run reversals in cocaine runway, females1.41.42.2-1.1-1.5-1.5-1.0-1.0-1.0-1.4-0.7
Run reversals in cocaine runway, males2.02.02.31.41.41.41.51.51.51.11.5
Latency to leave start box in cocaine runway0.30.30.60.20.70.70.50.50.60.5-0.4
Latency to leave start box in cocaine runway, F0.10.10.6-0.40.30.4-0.0-0.00.2-0.2-0.8
Latency to leave start box in cocaine runway, M0.80.71.30.80.80.80.90.90.91.20.5
Std. dev. time between licks in bursts0.91.22.8-0.9-1.0-1.0-1.2-1.1-1.0-1.7-0.7
Total sessions with >9 infusions2.02.54.62.11.81.91.51.41.50.31.3
Short access day 1 total inactive lever presses2.73.64.32.02.12.11.91.81.81.61.9
Short access day 10 total inactive lever presses1.02.32.81.31.51.51.71.71.51.71.5
Short access day 1 total infusions1.62.13.01.71.51.51.51.51.70.71.4
Short access day 10 total infusions0.10.10.30.60.20.20.20.20.10.10.1
Short access total infusions1.31.72.61.61.51.51.31.31.30.51.1
Short access day 1 locomotion0.10.10.30.40.50.5-0.0-0.00.3-0.3-0.2
Short access day 10 total locomotion0.71.32.4-0.9-0.9-0.8-1.2-1.3-1.2-1.1-1.6
Short access total locomotion0.10.10.20.40.00.1-0.4-0.4-0.3-0.4-0.4
One hour access (0.3 mA shock)0.70.92.7-1.0-0.5-0.5-1.0-0.9-0.7-0.5-1.7
Compulsive drug intake0.10.10.20.40.40.40.00.1-0.0-0.10.1
One hour access (shock baseline)0.50.81.9-1.3-0.6-0.6-0.8-0.8-0.6-0.4-1.4
Social response proportion0.30.41.10.50.40.30.70.70.61.10.3
Social responses0.20.21.20.2-0.4-0.4-0.3-0.3-0.3-1.10.3
Social time2.33.14.1-1.6-1.9-1.9-1.7-1.8-1.8-1.5-2.0
Soleus weight0.20.61.10.20.70.80.90.90.71.00.8
Bone: stiffness0.60.91.31.11.11.11.01.00.90.30.9
Tibialis anterior weight0.41.44.2-0.9-1.1-1.1-0.9-1.0-1.12.1-0.9
Time to tail flick, vehicle, before self-admin0.40.41.11.00.60.60.70.70.4-0.10.7
Time to tail flick, vehicle, after self-admin0.10.20.4-0.5-0.2-0.2-0.4-0.4-0.4-0.4-0.6
Time to tail flick, test, before self-admin0.20.20.60.30.30.20.30.30.50.70.8
Time to tail flick, test, after self-admin1.21.22.0-1.1-0.9-0.9-1.3-1.2-1.0-0.9-1.4
Delta time to tail flick, vehicle, before/after SA0.20.20.50.10.70.70.20.20.7-0.1-0.2
Delta time to tail flick, test, before/after SA2.22.24.2-1.5-1.2-1.1-1.5-1.5-1.4-1.5-2.1
Tibia length0.71.93.21.81.61.61.51.41.3-0.41.1
Ambulatory time before self-admin0.10.20.3-0.6-0.3-0.3-0.3-0.4-0.3-0.5-0.5
Ambulatory time after self-admin0.00.00.1-0.1-0.1-0.20.10.10.20.30.4
Bone: tissue strength0.40.40.80.50.70.80.40.50.5-0.90.2
Total heroin consumption1.01.22.21.01.11.11.11.01.10.41.5
Bone: trabecular number0.30.51.0-1.0-0.6-0.6-0.7-0.5-0.4-0.9-0.7
Bone: trabecular spacing0.91.22.11.41.21.21.21.11.00.71.0
Bone: trabecular thickness0.60.71.0-0.9-1.0-1.0-0.8-0.8-0.8-1.0-0.4
Bone: trabecular tissue density1.01.42.4-0.7-1.2-1.2-1.4-1.4-1.4-0.2-1.5
Water consumed over 24 hours4.15.49.51.82.12.12.42.42.43.12.1
Number of responses in last shaping day0.60.60.9-0.9-1.0-1.0-0.9-1.0-0.6-0.2-0.5