Tsks

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Tsks	0.04	0.04	2.5e-04	0.02	0.03	0.04	0.03	3.4e-03	3.1e-04	9.4e-05	2.1e-04
2	Liver	gene expression	Tsks	0.21	0.16	0.0e+00	0.13	0.12	0.12	0.12	8.2e-14	9.5e-14	2.4e-13	9.1e-14
3	NAcc	gene expression	Tsks	0.06	0.07	4.4e-05	0.02	0.02	0.02	0.02	2.5e-04	5.7e-04	2.0e-04	4.6e-04
4	Adipose	gene expression	Tsks	0.68	0.28	0.0e+00	0.18	0.18	0.18	0.18	3.9e-19	1.3e-19	4.2e-19	3.9e-19
5	pVTA	gene expression	Tsks	0.09	0.06	1.7e-07	0.08	0.09	0.09	0.08	7.4e-07	5.0e-08	6.6e-08	3.2e-07
6	Brain	mRNA stability	Tsks	0.05	0.04	2.4e-04	0.04	0.03	0.02	0.02	2.9e-04	7.7e-04	4.5e-03	4.7e-03
7	Brain	gene expression	Tsks	0.05	0.04	1.3e-04	0.04	0.04	0.04	0.04	1.4e-04	9.4e-05	7.3e-05	1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.3	0.6	1.1	0.3	1.0	0.8	-1.1	-0.9	0.7	0.3
Area under the delay curve	0.5	0.7	3.8	-0.7	-0.2	-0.5	0.4	0.5	-0.4	-2.0
BMI with tail	0.6	2.1	3.6	1.5	1.4	1.3	-1.9	-1.5	1.1	1.1
BMI without tail	0.0	0.2	1.2	0.1	-0.0	-0.0	0.3	-0.0	0.2	-1.1
Body weight	0.8	3.6	4.6	-2.0	-2.1	-2.1	2.0	2.0	-1.9	-1.2
Weight adjusted by age	0.0	0.1	0.2	0.4	0.5	0.1	-0.3	-0.1	-0.4	0.1
Bone surface	1.0	1.9	3.1	-0.4	1.8	1.5	-1.7	-1.6	1.4	0.9
Bone volume	0.4	0.7	1.3	-0.4	1.1	0.9	-1.1	-1.0	0.8	0.5
Breakpoint value in progressive ratio session	1.3	2.3	4.9	1.4	2.1	1.5	-2.2	-1.4	0.9	0.1
Number of licking bursts	0.0	0.1	0.2	0.1	0.4	0.3	-0.4	-0.3	0.1	-0.2
Context. condit. distance diff. score	6.3	7.6	10.4	2.1	3.0	3.1	-2.6	-3.1	3.2	1.9
Locomotion velocity, session 1	2.0	2.3	4.9	2.2	1.6	1.4	-1.6	-1.4	1.3	0.9
Locomotion distance, session 1	3.9	5.0	6.1	2.5	2.4	2.2	-2.2	-2.3	2.2	1.8
Locomotion velocity, session 2	0.3	0.4	1.4	1.2	0.5	0.6	-0.1	-0.5	0.7	0.1
Locomotion distance, session 2	0.4	0.6	0.9	0.7	0.9	0.7	-0.8	-0.8	0.8	0.5
Locomotion velocity, session 3	0.4	0.4	0.7	0.8	0.6	0.6	-0.6	-0.7	0.7	0.5
Locomotion distance, session 3	0.3	0.3	0.7	0.7	0.7	0.3	-0.9	-0.4	0.2	0.3
Stereotopy head waving bouts, day 3	0.9	1.0	2.2	1.3	0.8	1.0	-0.5	-1.1	1.5	0.5
Stereotopy head waving duration, day 3	1.1	1.4	2.6	1.3	1.0	1.3	-0.7	-1.3	1.6	0.8
Locomotion velocity, session 7	0.2	0.2	0.7	-0.4	-0.2	-0.2	0.2	0.3	-0.5	-0.9
Locomotion distance, session 7	0.2	0.3	0.6	-0.2	0.8	0.6	-0.6	-0.6	0.4	0.2
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.1	0.0	0.1	-0.4	-0.1	-0.1	0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.2	0.1	0.2	-0.5	-0.2	-0.0	0.5
Locomotion velocity, session 8	3.8	4.6	10.0	3.2	2.1	2.0	-2.0	-2.1	2.2	0.7
Locomotion distance, session 8	8.4	12.2	14.5	3.3	3.7	3.7	-3.4	-3.8	3.8	2.5
Degree of sensitization distance	0.1	0.1	0.1	-0.3	0.1	0.3	0.2	-0.2	0.3	0.2
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.4	-0.4	-0.5	-0.1	0.5	-0.8	0.0
Conditioned locomotion	0.2	0.3	0.7	-0.6	-0.6	-0.4	0.8	0.5	-0.1	0.1
Cocaine response after cond. corrected	0.8	1.2	1.9	-0.1	-0.8	-1.4	0.7	1.3	-1.4	-1.4
Cocaine response after cond. not corrected	0.7	1.0	1.7	-0.3	-0.7	-1.3	0.8	1.2	-1.3	-1.2
Cocaine response before conditioning	0.1	0.1	0.2	-0.2	0.2	0.5	-0.1	-0.4	0.4	0.3
Saline control response	0.2	0.3	0.5	-0.7	-0.4	-0.7	0.3	0.5	-0.5	0.1
Bone: connectivity density	1.9	3.1	4.2	0.8	2.0	2.0	-2.1	-2.0	1.8	1.0
Bone: cortical apparent density	1.3	2.0	4.3	-2.1	-1.3	-1.5	1.3	1.4	-1.4	-0.4
Bone: cortical area	0.2	0.4	1.2	-1.1	-0.3	-0.6	0.1	0.5	-0.7	-0.5
Bone: cortical porosity	0.1	0.1	0.6	0.8	-0.2	-0.2	0.3	0.2	0.1	0.1
Bone: cortical porosity	0.2	0.2	1.1	1.0	0.2	0.2	-0.0	-0.2	0.5	0.4
Bone: cortical thickness	0.6	1.0	1.4	-0.7	-0.8	-1.2	0.7	1.1	-1.2	-1.2
Bone: cortical thickness	0.1	0.1	0.2	0.5	0.5	0.2	-0.3	-0.3	0.4	0.1
Bone: cortical tissue density	1.2	2.0	4.2	-2.0	-1.3	-1.4	1.3	1.4	-1.4	-0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	-0.6	-0.0	-0.4	0.3	0.3	-0.1	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	0.3	0.1	-0.2	-0.2	0.2	-0.5
Condit. Reinf. active responses	0.5	0.6	1.3	-1.1	-0.5	-0.8	0.7	0.7	-0.6	-0.9
Condit. Reinf. inactive responses	1.0	1.2	2.1	-1.5	-1.2	-1.0	1.2	1.1	-1.0	-0.3
Incentive salience index mean	0.1	0.1	0.4	-0.4	0.1	-0.3	-0.0	0.1	-0.1	-0.7
Condit. Reinf. lever presses	0.7	1.0	1.6	-1.0	-0.8	-1.2	0.6	1.1	-1.3	-1.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.6	-1.3	-0.6	-0.8	0.7	0.7	-0.5	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.4	-0.5	-0.6	0.5	0.6	-0.5	-0.4
Condit. Reinf. active responses	0.5	0.7	3.0	-1.7	-0.6	-0.6	0.7	0.6	-0.4	-0.2
Condit. Reinf. inactive responses	0.2	0.3	1.7	-1.3	0.1	0.1	0.0	-0.1	0.2	0.2
Condit. Reinf. lever presses	0.3	0.5	3.1	-1.8	-0.0	-0.2	0.2	0.2	-0.3	-0.3
Condit. Reinf. lever reinforcers received	0.5	0.7	3.4	-1.8	-0.5	-0.6	0.6	0.6	-0.4	-0.2
Conditioned reinforcement - actives	0.0	0.1	0.3	0.4	-0.2	-0.1	0.4	-0.0	0.5	0.6
Conditioned reinforcement - inactives	0.1	0.2	1.0	0.2	-0.3	-0.1	0.2	0.1	-0.0	1.0
Conditioned locomotion	0.4	0.6	1.0	1.0	0.8	0.6	-0.4	-0.7	0.8	0.7
Patch foraging indifference point 0 sec	0.2	0.5	0.9	-1.0	-0.5	-0.8	0.2	0.7	-0.9	-0.3
Patch foraging indifference point AUC	0.4	0.9	1.6	1.3	0.9	0.9	-0.9	-1.0	1.0	0.4
Delay disc. indifference point, 0s delay	0.7	0.8	1.7	0.8	1.3	0.9	-1.0	-0.9	0.7	-0.2
Delay disc. indifference point, 16s delay	2.1	2.9	8.2	-1.4	-1.4	-1.5	1.7	1.4	-1.0	-2.9
Delay disc. indifference point, 2s delay	2.9	3.3	4.1	2.0	2.0	1.9	-1.9	-1.9	2.0	0.4
Delay disc. indifference point, 24s delay	0.2	0.3	1.8	0.2	-0.0	-0.2	0.5	0.0	0.4	-1.3
Delay disc. indifference point, 4s delay	0.4	0.4	1.9	-0.7	-0.2	-0.5	0.4	0.5	-0.3	-1.4
Delay disc. indifference point, 8s delay	0.8	1.4	2.7	-1.5	-0.7	-0.9	0.7	1.0	-1.3	-1.7
Indifference point function ln k	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1	-0.1	0.1	-0.3
Indifference point function log k	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1	-0.1	0.1	-0.3
Patch foraging total patch changes 0 sec	0.2	0.5	1.0	-1.0	-0.5	-0.8	0.1	0.7	-1.0	-0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.1	0.2	-0.1	-0.3	-0.1	0.1	0.1
Patch foraging total patch changes 18 sec	0.7	1.6	2.3	1.5	1.5	1.1	-1.5	-1.3	1.3	0.3
Patch foraging total patch changes 24 sec	1.3	4.4	6.5	2.2	2.4	2.2	-2.6	-2.2	1.8	0.9
Patch foraging total patch changes 6 sec	0.0	0.1	0.3	-0.1	0.2	-0.3	-0.2	0.1	-0.2	-0.6
Patch foraging time to switch 0 sec	0.3	1.0	1.4	-1.2	-1.1	-1.1	1.1	1.1	-0.7	-0.6
Patch foraging water rate 0 sec	0.1	0.4	0.7	0.7	0.8	0.7	-0.8	-0.7	0.2	-0.2
Patch foraging water rate 12 sec	0.3	1.1	1.7	0.9	1.3	1.0	-1.2	-1.0	0.9	-0.8
Patch foraging water rate 18 sec	0.3	0.7	1.4	0.4	1.0	0.9	-1.2	-0.8	0.3	-0.9
Patch foraging water rate 24 sec	1.4	2.0	2.8	1.7	1.6	1.4	-1.2	-1.4	1.6	-0.8
Patch foraging water rate 6 sec	1.1	1.7	2.7	1.1	1.6	1.4	-1.6	-1.4	1.0	-0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.1	0.9	0.9	0.9	-1.0	-0.9	0.8	0.0
Distance traveled before self-admin	0.6	1.2	1.6	1.2	1.3	1.1	-1.3	-1.1	1.0	0.7
Distance traveled after self-admin	0.2	0.4	0.5	0.7	0.7	0.6	-0.5	-0.6	0.7	-0.3
Extensor digitorum longus weight	2.2	9.0	10.0	3.1	3.1	3.1	-3.0	-3.2	3.1	2.3
Bone: elastic displacement	1.7	2.1	3.2	1.8	1.4	1.5	-1.4	-1.5	1.6	0.7
Bone: elastic work	0.5	0.6	0.9	0.6	0.9	0.8	-1.0	-0.9	0.8	0.1
Bone: endosteal estimation	0.6	1.4	2.0	-0.1	1.1	1.4	-1.3	-1.3	1.2	1.4
Bone: endosteal perimeter	0.2	0.5	0.7	-0.4	0.6	0.9	-0.8	-0.8	0.6	0.7
Epididymis fat weight	0.1	0.4	1.4	-0.0	-0.6	-0.6	1.2	0.4	0.3	-0.4
Delta time in closed arm before/after self-admin	3.1	2.9	4.9	-1.6	-1.7	-1.9	2.2	1.8	-1.3	-1.3
Delta time in open arm before/after self-admin	0.4	0.5	1.1	0.6	0.7	0.7	-1.1	-0.7	0.7	0.1
Diff in mean of infusions in LGA sessions	0.8	1.4	2.5	1.4	1.3	1.1	-1.6	-1.1	0.7	0.9
Delay discount exponential model param	0.6	0.8	4.0	0.8	0.3	0.5	-0.4	-0.5	0.4	2.0
Extinction: sum of active levers before priming	0.1	0.2	0.7	0.8	0.5	0.2	-0.2	-0.3	0.4	0.3
Active lever presses in extinction session 6	0.5	0.5	0.8	0.9	0.9	0.7	-0.6	-0.7	0.6	0.2
Bone: final force	0.0	0.1	0.3	-0.6	-0.0	-0.2	-0.0	0.2	-0.4	-0.0
Bone: final moment	0.2	0.3	0.8	-0.9	-0.3	-0.5	0.2	0.5	-0.6	-0.2
Food consumed during 24 hour testing period	0.7	1.4	2.8	-1.7	-1.1	-1.2	1.1	1.2	-1.3	-0.8
Glucose	0.2	0.3	1.3	-0.4	-0.4	-0.5	0.3	0.5	-0.4	-1.1
Heart weight	0.8	1.3	1.6	1.2	1.1	1.2	-1.2	-1.2	1.3	0.8
Delay discount hyperbolic model param	0.4	0.5	3.1	0.4	-0.0	0.2	-0.2	-0.2	0.1	1.8
Intermittent access intake day 1-15 change	0.7	3.6	5.0	1.8	1.7	2.1	-2.2	-1.9	1.7	1.7
Intermittent access intake escalation	0.5	3.0	4.6	1.6	1.6	2.0	-2.2	-1.7	1.5	1.4
Intermittent access intake escalation 2	0.8	1.3	2.8	0.8	1.0	1.2	-1.5	-0.9	0.5	1.7
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.6	1.2	0.8	0.6	-0.3	-0.8	1.3	0.5
Intermitt. access day 15 inactive lever presses	0.4	2.3	3.9	-2.0	-1.5	-1.5	1.2	1.6	-1.6	-1.1
Intermitt. access escalation Index	0.2	0.6	1.1	-0.7	-1.0	-0.8	0.8	0.7	-0.7	0.5
Intermittent access day 1 total infusions	0.9	2.6	3.3	-1.6	-1.6	-1.8	1.8	1.7	-1.7	-0.8
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.5	-0.3	-0.1	-0.0	0.3	-0.4	0.1
Intermittent access terminal intake (last 3 days)	0.1	0.2	1.1	0.0	-0.1	0.1	-0.2	-0.0	-0.2	1.0
Intermittent access total infusions	0.8	1.0	1.4	-1.1	-1.1	-1.0	0.9	1.1	-1.2	-0.2
Intermittent access day 1 locomotion	0.3	0.5	0.8	-0.5	-0.6	-0.8	0.9	0.6	-0.7	-0.9
Intermittent access day 15 total locomotion	0.5	1.9	2.8	1.7	1.5	1.4	-1.4	-1.5	1.3	0.6
Intermittent access total locomotion	0.0	0.0	0.2	0.2	0.2	-0.0	0.0	-0.1	0.0	-0.4
Intermittent access standard deviation	0.1	0.5	1.5	0.3	0.8	0.9	-1.2	-0.6	0.2	0.5
Left kidney weight	2.8	22.6	27.4	-5.2	-5.0	-5.1	5.0	4.9	-4.5	-3.1
Right kidney weight	3.1	21.4	28.0	-5.3	-4.6	-4.8	4.5	4.8	-4.6	-3.6
Cocaine induced anxiety	0.1	0.3	0.5	-0.7	-0.3	-0.4	0.4	0.5	-0.7	-0.5
Post-drug Anxiety	0.4	0.4	1.1	0.3	0.7	0.8	-1.0	-0.6	0.2	-0.0
Baseline Anxiety	0.4	0.7	1.1	0.9	0.6	0.8	-0.8	-0.9	1.1	0.6
Tail length	1.8	9.5	11.9	-3.3	-3.0	-3.0	3.4	3.1	-2.7	-3.1
Length with tail	2.7	12.1	15.2	-3.7	-3.7	-3.6	3.9	3.6	-3.3	-2.3
Length without tail	0.4	2.3	3.0	-1.7	-1.7	-1.7	1.4	1.7	-1.6	0.0
Times rat made contact with spout	0.3	0.4	0.6	-0.8	-0.8	-0.4	0.6	0.5	-0.5	-0.6
Lifetime Intake	2.5	3.0	4.0	-2.0	-1.9	-1.8	1.7	1.8	-2.0	-0.7
Liver weight, left	0.0	0.1	0.2	0.0	-0.2	-0.3	0.4	0.2	0.3	-0.3
Liver weight, right	0.3	0.5	1.4	-0.5	-0.5	-0.7	0.8	0.6	-0.1	-1.2
Locomotor activity	0.6	1.0	1.8	-1.3	-1.2	-1.1	0.6	1.0	-1.2	0.1
Locomotor testing distance	0.0	0.1	0.3	-0.5	-0.3	-0.1	-0.4	0.1	-0.2	0.6
Locomotor testing rearing	0.1	0.3	0.9	-0.9	-0.5	-0.5	-0.1	0.5	-0.7	0.1
Locomotion in novel chamber	0.7	0.9	2.0	-1.0	-0.7	-1.0	0.7	1.1	-1.4	-0.2
Locomotion in novel chamber post-restriction	0.4	1.2	1.5	1.1	1.1	1.2	-1.2	-1.1	0.8	0.9
Fecal boli incidents, locomotor time 1	0.5	1.3	2.2	-1.4	-1.2	-1.1	0.9	1.2	-1.5	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	0.2	0.4	0.3	-0.4	-0.3	0.0	-0.7
Time >=10cm from walls, locomotor time 1	3.9	4.8	7.2	-2.7	-2.4	-2.2	2.2	2.3	-2.4	-0.7
Bouts of movement, locomotor time 1	2.9	3.7	5.3	-2.1	-1.7	-1.9	1.8	1.9	-1.7	-2.3
Total resting periods, locomotor time 1	2.9	3.4	4.0	-2.0	-1.8	-1.9	1.9	1.9	-1.6	-1.9
Rest time, locomotor task time 1	0.3	0.5	1.1	-0.5	-1.0	-0.7	1.1	0.7	-0.2	0.4
Distance moved, locomotor task time 1	2.0	5.7	8.3	2.8	2.9	2.4	-2.4	-2.5	2.4	0.2
Vertical activity count, locomotor time 1	0.1	0.5	1.3	0.3	1.2	0.4	-0.8	-0.4	0.0	-1.0
Time >=10cm from walls, locomotor time 2	0.5	1.6	2.6	-1.2	-1.5	-1.3	1.6	1.3	-1.1	-0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.5	-0.5	-0.7	-0.5	0.6	0.5	-0.1	0.1
Total resting periods, locomotor time 2	0.1	0.3	0.7	-0.6	-0.8	-0.5	0.6	0.5	-0.0	0.2
Rest time, locomotor task time 2	0.5	0.9	1.9	-0.9	-1.4	-0.9	1.1	0.9	-0.5	0.6
Distance moved, locomotor task time 2	1.3	1.7	2.4	1.5	1.5	1.4	-1.3	-1.4	1.2	-0.0
Vertical activity count, locomotor time 2	0.1	0.3	1.4	-0.3	0.1	-0.2	0.0	0.2	-0.6	-1.2
Light reinforcement 1	0.1	0.6	0.9	0.9	0.8	0.9	-0.7	-0.8	0.9	-0.2
Light reinforcement 2	0.1	0.2	0.3	0.5	0.4	0.5	-0.4	-0.5	0.5	0.2
Bone: marrow area	0.6	1.5	2.2	-0.0	1.1	1.5	-1.3	-1.4	1.2	1.5
Bone: maximum diameter	0.2	0.4	1.4	-1.2	-0.4	-0.4	0.0	0.5	-0.7	-0.6
Bone: maximum force	0.3	0.5	1.0	0.0	0.9	0.8	-1.0	-0.8	0.5	0.7
Bone: maximum moment	0.1	0.2	0.5	-0.3	0.6	0.4	-0.7	-0.5	0.3	0.5
Mean time between licks in bursts	0.0	0.1	0.4	0.3	-0.3	-0.3	0.3	0.2	-0.2	-0.7
Mean num. licks in bursts	0.0	0.1	0.2	-0.3	-0.4	-0.1	0.3	0.1	0.0	0.1
Cd content in liver	1.8	2.0	2.5	-1.6	-1.5	-1.5	1.4	1.5	-1.5	-0.8
Co content in liver	0.3	0.3	0.6	-0.3	-0.5	-0.6	0.2	0.5	-0.7	-0.7
Cu content in liver	1.0	1.2	1.8	1.0	1.1	1.2	-1.0	-1.3	1.3	0.6
Fe content in liver	2.2	2.7	4.0	0.7	2.0	1.9	-1.9	-1.8	1.6	1.1
K content in liver	0.1	0.1	0.6	-0.4	0.2	-0.0	-0.1	0.0	-0.3	-0.8
Mg content in liver	0.2	0.3	0.4	-0.4	-0.4	-0.5	0.5	0.5	-0.6	-0.6
Mn content in liver	0.2	0.3	0.9	0.6	0.2	0.3	-0.6	-0.2	-0.1	1.0
Na content in liver	0.3	0.3	0.6	0.3	0.6	0.6	-0.8	-0.5	0.3	0.7
Rb content in liver	1.8	2.1	2.7	0.5	1.6	1.6	-1.5	-1.6	1.6	1.3
Se content in liver	0.3	0.3	0.5	0.1	0.6	0.7	-0.5	-0.7	0.6	0.4
Sr content in liver	0.0	0.0	0.1	-0.3	0.3	0.1	-0.2	-0.2	0.1	-0.0
Zn content in liver	0.3	0.3	0.6	-0.8	-0.5	-0.6	0.6	0.5	-0.4	-0.5
Bone: minimum diameter	1.1	2.1	3.0	0.3	1.4	1.6	-1.7	-1.6	1.5	1.7
Time in familiar zone, hab. session 1	0.0	0.0	0.2	-0.4	-0.1	-0.0	-0.0	0.1	-0.2	0.0
Time in novel zone, hab. session 1	0.2	0.2	0.7	0.8	0.5	0.2	-0.3	-0.3	0.4	0.1
Total zone transitions, hab. session 1	1.1	1.5	2.8	1.7	1.3	1.2	-1.3	-1.2	1.1	0.7
Total locomotion distance, hab. session 1	0.5	0.7	1.0	0.8	0.9	0.9	-0.6	-0.9	1.0	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.5	0.3	0.4	0.1	-0.3	0.5	0.1
Time in familiar zone, hab. session 2	0.3	0.3	2.1	-1.4	-0.3	-0.2	0.4	0.2	-0.1	0.0
Time in novel zone, hab. session 2	1.4	1.6	3.7	1.9	1.3	1.2	-1.3	-1.2	1.0	0.5
Total zone transitions, hab. session 2	1.0	1.2	1.7	1.1	1.3	1.1	-0.9	-1.2	1.3	0.8
Total locomotion distance, hab. session 2	0.6	0.8	1.7	0.6	1.0	0.9	-0.4	-1.0	1.3	0.8
Locomotion velocity, hab. session 2	0.2	0.2	0.6	0.3	0.4	0.4	0.1	-0.5	0.8	0.5
Novel to familiar place preference ratio	0.2	0.3	0.4	-0.4	-0.5	-0.5	0.5	0.6	-0.7	-0.5
Novelty place preference	0.2	0.2	0.3	-0.3	-0.5	-0.4	0.5	0.5	-0.5	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	-0.2	-0.4	-0.3	0.4	0.4	-0.4	-0.4
Total zone transitions, NPP test	2.1	3.1	6.2	2.5	1.9	1.6	-1.8	-1.7	1.7	0.8
Total locomotion distance, NPP test	3.3	4.6	6.0	2.3	2.4	2.1	-1.9	-2.3	2.4	1.3
Locomotion velocity, NPP test	2.5	3.5	4.4	2.1	2.1	1.8	-1.7	-2.0	2.1	1.2
Intraocular pressure	3.4	5.5	8.0	-2.8	-2.2	-2.4	2.1	2.5	-2.6	-1.7
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.3	-0.4	-0.5	0.5	0.4	-0.3	-0.6
Delta ambulatory time before/after self-admin	0.0	0.0	0.3	-0.0	-0.1	-0.1	0.2	0.0	0.1	-0.5
Parametrial fat weight	2.0	4.8	6.3	-2.5	-2.2	-2.1	2.3	2.2	-2.0	-1.9
Pavlov. Cond. lever latency	0.5	0.6	1.0	0.4	0.6	1.0	-0.5	-0.9	0.9	0.9
Pavlov. Cond. magazine entry latency	0.8	1.0	1.5	-1.2	-0.5	-1.2	0.9	0.9	-0.8	-1.1
Pavlov. Cond. change in total contacts	0.5	0.5	1.1	-0.4	-0.4	-0.9	0.4	0.7	-0.8	-1.1
Pavlov. Cond. index score	1.6	2.1	3.2	-1.2	-1.2	-1.8	1.3	1.6	-1.5	-1.3
Pavlov. Cond. latency score	1.6	2.1	3.3	-1.2	-1.3	-1.8	1.3	1.6	-1.5	-1.3
Pavlov. Cond. lever contacts	1.0	1.2	1.8	-0.7	-1.0	-1.3	1.0	1.2	-1.1	-1.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.4	0.9	0.6	1.2	-0.8	-1.0	0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.4	1.2	0.9	1.1	-0.9	-1.0	1.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.6	-0.8	-0.7	-1.3	0.9	1.1	-1.0	-1.1
Pavlov. Cond. response bias	1.1	1.4	2.1	-0.9	-0.9	-1.4	1.1	1.3	-1.2	-1.4
Pavlov. Cond. lever latency	0.6	0.8	1.5	0.2	-1.2	-1.0	1.1	1.0	-0.8	-0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	-0.3	0.6	0.6	-0.4	-0.6	0.8	0.4
Pavlov. Cond. change in total contacts	0.2	0.4	2.9	-1.7	-0.0	-0.2	0.2	0.2	-0.1	-0.1
Pavlov. Cond. index score	0.4	0.6	1.1	-0.6	1.0	0.8	-0.8	-0.8	0.8	0.3
Pavlov. Cond. latency score	0.4	0.6	1.1	-0.3	1.1	0.9	-0.9	-0.9	0.8	0.3
Pavlov. Cond. lever contacts	0.5	0.7	1.4	-0.2	1.2	0.9	-1.1	-0.9	0.8	0.4
Pavlov. Cond. magazine entry number	0.7	0.9	1.3	0.2	-1.1	-1.1	0.9	1.1	-1.1	-0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.5	-0.7	-1.2	-0.9	1.2	0.9	-0.6	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.7	0.9	0.7	-0.7	-0.7	0.7	0.2
Pavlov. Cond. response bias	0.6	0.9	1.4	-0.5	1.2	1.1	-1.1	-1.0	0.9	0.5
Time in closed arm before self-admin	0.3	0.5	0.7	0.9	0.9	0.6	-0.9	-0.7	0.5	-0.6
Time in closed arm after self-admin	1.1	1.3	2.9	1.7	1.4	0.9	-0.6	-1.1	1.4	-0.0
Time in open arm before self-admin	0.5	0.7	1.8	-0.6	-0.8	-0.8	1.3	0.8	-0.6	-0.2
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1	-0.0	0.2	0.1
Bone: periosteal estimation	0.2	0.5	1.0	-0.6	0.7	0.7	-1.0	-0.7	0.5	0.7
Bone: periosteal perimeter	0.1	0.2	0.4	-0.2	0.3	0.4	-0.6	-0.4	0.3	0.5
Bone: post-yield work	0.4	0.7	1.3	0.2	1.0	0.9	-1.1	-0.9	0.6	0.6
Progressive ratio test 1 active lever presses	2.4	4.2	6.1	-2.1	-2.5	-2.1	2.4	2.1	-1.8	-0.9
Progressive ratio test 1 breakpoint	2.3	3.9	5.8	-2.0	-2.4	-2.1	2.4	2.0	-1.7	-0.7
Progressive ratio test 1 inactive lever presses	0.7	1.8	2.5	-1.3	-1.5	-1.5	1.6	1.4	-1.2	-0.6
Progressive ratio test 2 active lever presses	0.5	0.7	1.3	-1.1	-0.7	-0.7	0.4	0.8	-1.1	-0.9
Progressive ratio test 2 breakpoint	0.9	1.1	1.9	-1.4	-0.9	-0.9	0.6	1.0	-1.3	-1.0
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.3	0.1	-0.1	-0.2	0.1	-0.4	-0.4
Incentive Sensitization - Responses	0.2	0.5	1.3	0.3	0.9	0.7	-1.1	-0.6	0.1	-0.4
Incentive Sensitization - Breakpoint	0.2	0.4	1.3	0.2	0.9	0.6	-1.1	-0.5	0.0	-0.5
Sum of active levers in priming session hrs 5-6	4.7	4.4	6.5	2.0	2.2	2.3	-2.6	-2.1	1.6	1.8
Progressive ratio	0.1	0.2	0.5	-0.7	-0.1	-0.1	-0.2	0.4	-0.7	-0.0
Food seeking constrained by brief footshock	0.5	0.6	0.7	-0.8	-0.8	-0.8	0.7	0.8	-0.8	-0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.2	-0.4	-0.3	0.6	0.1	0.3	-0.3
Retroperitoneal fat weight	1.3	5.8	8.6	-2.4	-2.6	-2.5	2.9	2.4	-1.9	-2.0
Reaction time number correct	1.7	6.1	8.8	3.0	2.6	2.6	-2.5	-2.7	2.5	0.6
Reaction time mean minus median	0.1	0.4	0.6	0.8	0.7	0.5	-0.7	-0.6	0.6	0.2
Reaction time mean minus median AUC	0.0	0.1	0.3	0.6	0.2	0.3	-0.2	-0.3	0.4	0.3
Reaction time num false alarms	0.7	1.2	2.7	1.6	0.9	0.9	-0.6	-1.1	1.4	0.8
Reaction time num false alarms AUC	0.1	0.1	0.4	0.6	-0.0	0.1	0.3	-0.2	0.5	0.3
Reaction time trials correct on left	1.7	6.1	8.8	3.0	2.6	2.6	-2.5	-2.7	2.5	0.6
Reaction time trials on left	1.6	5.4	7.8	2.8	2.4	2.5	-2.4	-2.5	2.4	0.6
Reaction time mean	0.6	1.2	1.5	-1.2	-1.2	-1.1	1.1	1.2	-1.1	-0.8
Reaction time mean AUC	0.5	1.2	1.5	-1.2	-1.2	-1.1	1.1	1.1	-1.1	-0.6
Median of all reaction times	1.7	2.7	3.4	-1.9	-1.8	-1.7	1.7	1.7	-1.6	-1.0
Reaction time omissions	1.5	2.5	3.7	-1.8	-1.7	-1.8	1.2	1.7	-1.9	-0.6
Reaction time false alarm rate	0.4	0.6	1.4	-0.5	-1.0	-0.9	1.2	0.8	-0.4	0.0
Reaction time premature initiation rate	1.5	2.3	3.7	-1.9	-1.3	-1.6	1.1	1.6	-1.8	-1.0
Reaction time premature initiations	0.1	0.2	0.4	-0.4	-0.1	-0.3	-0.2	0.3	-0.6	-0.7
Std. dev. reaction times	0.0	0.1	0.2	-0.2	-0.4	-0.3	0.3	0.3	-0.3	-0.0
Reaction time trials completed	1.6	5.4	7.8	2.8	2.4	2.5	-2.4	-2.5	2.4	0.6
Reaction time trials AUC	1.4	4.9	7.2	2.7	2.2	2.3	-2.2	-2.4	2.3	0.5
Run reversals in cocaine runway, females	1.3	1.5	2.9	1.7	0.8	0.9	-0.6	-1.2	1.4	1.4
Run reversals in cocaine runway, males	0.6	0.6	1.0	0.8	1.0	0.7	-0.7	-0.7	0.8	0.8
Latency to leave start box in cocaine runway	6.6	9.1	13.0	3.6	3.4	3.0	-3.0	-3.2	3.1	1.1
Latency to leave start box in cocaine runway, F	5.5	6.9	9.2	3.0	3.0	2.6	-2.9	-2.8	2.6	0.6
Latency to leave start box in cocaine runway, M	2.7	2.6	4.3	2.1	1.7	1.6	-1.3	-1.7	1.8	1.0
Std. dev. time between licks in bursts	0.0	0.1	0.3	-0.6	0.0	-0.2	-0.1	0.1	-0.2	0.1
Total sessions with >9 infusions	5.7	7.1	9.3	-3.0	-2.6	-2.7	2.5	2.7	-2.8	-2.1
Short access day 1 total inactive lever presses	0.1	0.2	0.7	-0.7	-0.3	-0.3	-0.0	0.5	-0.8	-0.2
Short access day 10 total inactive lever presses	0.5	3.3	4.9	2.2	1.8	1.8	-1.5	-1.8	2.1	1.4
Short access day 1 total infusions	1.8	3.5	4.3	-2.1	-1.9	-1.9	1.9	1.9	-2.0	-1.2
Short access day 10 total infusions	4.2	6.9	8.0	-2.8	-2.7	-2.7	2.7	2.7	-2.6	-2.0
Short access total infusions	6.4	9.1	11.5	-3.4	-3.1	-3.1	3.0	3.1	-3.2	-1.9
Short access day 1 locomotion	1.3	2.2	2.6	-1.5	-1.3	-1.6	1.6	1.5	-1.5	-1.2
Short access day 10 total locomotion	0.1	0.6	1.1	-0.6	-0.8	-0.8	1.1	0.8	-0.4	-0.7
Short access total locomotion	2.3	3.4	4.3	-2.0	-1.6	-1.8	1.8	1.8	-1.9	-2.1
One hour access (0.3 mA shock)	0.2	0.2	0.5	0.2	0.6	0.4	-0.7	-0.3	-0.1	0.4
Compulsive drug intake	0.4	0.6	2.3	0.1	0.7	0.9	-1.5	-0.6	-0.1	0.8
One hour access (shock baseline)	0.0	0.1	0.1	-0.2	-0.1	-0.3	0.2	0.2	-0.4	0.2
Social response proportion	3.9	5.0	6.7	-2.4	-2.5	-2.5	2.1	2.4	-2.6	0.2
Social responses	2.1	2.7	3.7	-1.9	-1.6	-1.9	1.4	1.8	-1.9	-0.3
Social time	0.3	0.5	0.8	0.8	0.8	0.6	-0.9	-0.7	0.7	0.4
Soleus weight	1.6	4.7	6.4	1.9	2.5	2.4	-2.3	-2.4	2.1	1.1
Bone: stiffness	0.3	0.5	1.2	0.2	0.6	0.7	-0.5	-0.7	0.7	1.1
Tibialis anterior weight	0.3	1.1	1.6	1.3	1.2	1.1	-1.1	-1.1	0.9	0.2
Time to tail flick, vehicle, before self-admin	0.4	0.5	1.0	0.8	0.6	0.8	-0.3	-0.8	1.0	0.1
Time to tail flick, vehicle, after self-admin	1.1	2.3	7.5	1.8	0.9	0.9	-0.6	-1.1	1.4	2.7
Time to tail flick, test, before self-admin	0.6	0.7	1.2	0.6	0.7	1.1	-0.9	-0.9	0.5	0.9
Time to tail flick, test, after self-admin	1.5	1.6	3.7	1.4	1.9	1.1	-1.3	-1.2	1.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	2.1	0.4	0.2	0.1	-0.2	-0.2	0.2	1.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	0.1	0.2	-0.5	0.4	0.3	-0.0	-0.8
Tibia length	3.9	10.8	15.5	-3.9	-3.3	-3.3	2.9	3.4	-3.5	-2.5
Ambulatory time before self-admin	0.2	0.6	1.0	0.8	1.0	0.7	-1.0	-0.7	0.6	0.1
Ambulatory time after self-admin	0.2	0.4	0.6	0.7	0.8	0.4	-0.5	-0.5	0.6	-0.8
Bone: tissue strength	0.2	0.2	0.6	-0.3	-0.2	-0.3	-0.0	0.3	-0.6	-0.7
Total heroin consumption	3.6	4.3	9.9	1.5	2.3	2.2	-3.2	-1.9	0.9	1.9
Bone: trabecular number	0.6	1.2	1.8	0.6	1.3	1.2	-1.3	-1.2	1.0	0.6
Bone: trabecular spacing	0.6	0.8	1.1	-0.4	-1.1	-0.9	1.0	1.0	-1.1	-0.7
Bone: trabecular thickness	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.1	0.1	0.1	0.1
Bone: trabecular tissue density	0.8	1.4	3.5	-1.9	-1.2	-1.1	1.4	1.1	-0.8	0.1
Water consumed over 24 hours	0.0	0.1	0.1	-0.0	0.3	0.3	-0.2	-0.3	0.3	-0.0
Number of responses in last shaping day	2.7	3.5	4.9	-1.7	-1.7	-2.0	2.2	1.9	-1.5	-2.0