Hub : Genes

Trim35

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Trim35 0.03 0.02 3.3e-03 0.02 0.02 0.01 0.02 1.5e-03 3.1e-03 2.3e-02 2.2e-03
2 Liver gene expression Trim35 0.1 0.07 8.4e-07 0.04 0.04 0.04 0.04 2.2e-05 5.5e-05 5.3e-05 5.9e-05
3 OFC mRNA stability Trim35 0.17 0.12 9.0e-03 0.07 0.03 0.03 0.05 7.5e-03 6.9e-02 7.9e-02 2.5e-02
4 pVTA gene expression Trim35 0.15 0.08 1.4e-06 0.16 0.14 0.15 0.14 2.4e-07 1.8e-06 7.2e-07 8.0e-07
5 Brain mRNA stability Trim35 0.77 0.09 0.0e+00 0.47 0.48 0.48 0.49 1.1e-48 1.4e-50 1.7e-50 2.9e-51
6 PL mRNA stability Trim35 0.62 0.14 0.0e+00 0.31 0.3 0.31 0.31 2.0e-34 7.4e-34 4.7e-35 4.1e-35
7 BLA mRNA stability Trim35 0.33 0.17 7.1e-10 0.08 0.1 0.1 0.09 2.9e-05 2.9e-06 5.7e-06 9.9e-06
8 NAcc mRNA stability Trim35 0.2 0.09 0.0e+00 0.22 0.19 0.21 0.22 7.9e-25 1.1e-21 1.9e-23 1.0e-24
9 pVTA mRNA stability Trim35 0.15 0.09 8.6e-06 0.06 0.08 0.07 0.08 1.9e-03 1.9e-04 3.7e-04 3.3e-04
10 LHb gene expression Trim35 0.16 0.11 9.3e-03 0.06 0.05 0.02 0.05 1.6e-02 2.1e-02 1.3e-01 2.9e-02
11 NAcc gene expression Trim35 0.04 0.03 1.7e-03 0.02 0 -0 0.01 3.5e-03 2.0e-01 4.0e-01 1.6e-02
12 BLA gene expression Trim35 0.1 0.07 4.1e-03 0.03 0.02 0.03 0.02 1.0e-02 2.9e-02 1.2e-02 2.9e-02
13 Adipose gene expression Trim35 0.13 0.09 5.6e-09 0.07 0.07 0.06 0.07 3.5e-08 3.4e-08 2.3e-07 5.8e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.42.33.21.4-0.21.7-1.7-1.5-1.6-1.71.6-1.8-1.6-1.51.71.4
Area under the delay curve0.10.10.30.40.60.5-0.0-0.1-0.1-0.00.00.10.30.3-0.1-0.3
BMI with tail0.62.03.2-1.5-1.0-1.81.61.61.61.5-1.41.41.61.5-1.1-0.6
BMI without tail0.20.52.70.1-1.6-0.00.30.40.3-0.2-0.3-0.50.20.20.91.6
Body weight0.10.41.40.10.9-0.20.20.30.30.5-0.20.70.50.4-1.2-1.0
Weight adjusted by age0.50.62.50.01.6-0.00.2-0.10.00.30.00.6-0.1-0.2-1.5-1.6
Bone surface1.42.43.71.50.51.9-1.9-1.8-1.8-1.61.7-1.6-1.5-1.51.30.8
Bone volume1.52.54.31.60.62.1-1.9-1.8-1.9-1.71.7-1.6-1.5-1.51.30.8
Breakpoint value in progressive ratio session0.20.20.6-0.5-0.2-0.3-0.5-0.4-0.5-0.30.6-0.3-0.6-0.80.60.0
Number of licking bursts0.20.31.2-0.7-1.1-0.30.60.50.50.4-0.40.20.40.40.40.4
Context. condit. distance diff. score2.32.811.3-1.5-3.4-1.51.71.61.60.8-1.70.21.31.31.12.2
Locomotion velocity, session 10.40.41.10.00.80.1-0.6-0.7-0.6-0.50.7-0.4-1.0-1.00.1-0.4
Locomotion distance, session 11.31.63.81.21.91.2-1.1-1.1-1.1-1.11.2-0.8-1.8-1.8-0.5-0.6
Locomotion velocity, session 20.60.72.00.61.40.6-0.8-0.9-0.9-0.60.9-0.4-1.2-1.2-0.2-0.8
Locomotion distance, session 21.92.75.31.52.21.5-1.7-1.6-1.7-1.41.8-1.1-2.3-2.3-0.2-0.7
Locomotion velocity, session 31.82.13.3-1.5-0.7-1.81.71.61.61.5-1.71.51.51.5-1.1-0.7
Locomotion distance, session 30.70.71.3-0.9-1.1-1.00.91.01.00.8-1.10.60.80.8-0.20.2
Stereotopy head waving bouts, day 30.20.31.1-0.50.6-0.70.30.30.30.5-0.10.6-0.1-0.1-0.9-1.0
Stereotopy head waving duration, day 31.11.33.6-0.71.2-1.00.90.90.91.2-0.71.40.70.7-1.9-1.9
Locomotion velocity, session 72.42.613.6-0.8-3.7-0.71.01.01.0-0.0-1.2-0.70.90.91.83.1
Locomotion distance, session 72.02.511.40.0-3.10.0-0.4-0.2-0.3-1.10.2-1.7-0.3-0.32.83.4
Stereotopy head waving bouts, day 71.01.13.5-0.41.3-0.70.80.80.81.0-0.81.20.60.6-1.9-1.7
Stereotopy head waving duration, day 72.12.66.1-1.11.1-1.21.51.41.51.8-1.51.91.31.3-2.5-2.2
Locomotion velocity, session 80.81.01.7-1.2-0.9-1.21.31.31.31.0-1.10.80.70.7-0.6-0.1
Locomotion distance, session 80.20.31.2-0.1-1.0-0.20.30.30.3-0.3-0.2-0.5-0.5-0.50.51.1
Degree of sensitization distance3.23.310.31.0-2.01.1-1.3-1.2-1.2-1.91.3-2.3-1.0-1.03.03.2
Degree of sensitization stereotypy1.01.12.7-0.40.9-0.71.00.91.01.1-0.91.20.90.9-1.6-1.4
Conditioned locomotion0.30.31.1-1.0-1.0-1.10.40.40.40.2-0.30.10.0-0.00.50.4
Cocaine response after cond. corrected2.12.35.9-2.4-2.1-1.71.41.51.51.4-1.71.11.41.40.20.2
Cocaine response after cond. not corrected1.01.23.5-1.9-1.5-1.50.91.01.01.0-1.10.80.90.90.20.2
Cocaine response before conditioning2.12.54.02.01.91.5-1.8-1.8-1.8-1.61.8-1.3-1.7-1.70.5-0.0
Saline control response0.81.01.81.41.01.3-1.2-1.1-1.1-1.01.2-0.9-1.0-1.00.20.1
Bone: connectivity density2.13.25.61.3-0.91.5-1.8-1.7-1.7-2.01.7-2.2-2.0-1.82.42.1
Bone: cortical apparent density1.01.33.8-1.2-2.0-1.21.01.01.00.8-1.10.61.61.50.30.7
Bone: cortical area0.10.20.60.70.70.8-0.3-0.3-0.3-0.30.3-0.10.20.1-0.3-0.2
Bone: cortical porosity0.50.62.80.31.70.10.1-0.00.00.30.00.6-0.2-0.2-1.2-1.6
Bone: cortical porosity0.50.63.40.61.80.4-0.1-0.2-0.20.10.20.4-0.2-0.2-1.2-1.4
Bone: cortical thickness0.10.10.50.40.20.30.20.20.20.2-0.20.20.70.6-0.4-0.1
Bone: cortical thickness0.30.41.1-0.5-1.0-0.10.60.50.60.5-0.50.40.91.00.20.4
Bone: cortical tissue density1.21.64.1-1.3-2.0-1.31.11.11.10.9-1.20.71.71.70.20.7
Condit. Reinf. active minus inactive responses0.30.31.90.51.40.7-0.4-0.6-0.5-0.20.40.0-0.3-0.3-0.3-0.8
Condit. Reinf. active-inactive response ratio0.60.71.3-1.20.2-0.70.80.70.81.0-0.81.00.50.5-0.8-1.1
Condit. Reinf. active responses1.31.73.61.61.91.7-1.3-1.5-1.4-1.21.2-0.9-1.2-1.20.3-0.4
Condit. Reinf. inactive responses4.65.510.13.21.92.8-2.4-2.5-2.5-2.62.4-2.4-2.3-2.31.30.9
Incentive salience index mean0.80.94.61.02.11.2-0.7-0.9-0.8-0.30.70.0-0.5-0.5-0.7-1.3
Condit. Reinf. lever presses1.41.96.21.62.51.7-1.3-1.4-1.4-0.91.4-0.5-1.0-1.0-0.5-1.2
Condit. Reinf. active minus inactive responses0.30.40.80.50.20.7-0.6-0.5-0.5-0.70.7-0.7-0.9-0.90.40.3
Condit. Reinf. active-inactive response ratio0.50.51.0-0.9-0.6-0.70.91.00.90.7-0.70.60.50.6-0.5-0.2
Condit. Reinf. active responses0.81.11.41.00.31.1-1.1-1.0-1.0-1.21.1-1.2-1.2-1.20.90.8
Condit. Reinf. inactive responses2.83.44.51.80.51.8-2.1-2.0-2.0-2.11.9-2.1-1.9-2.01.81.4
Condit. Reinf. lever presses0.91.23.01.41.71.6-1.2-1.2-1.2-0.91.1-0.6-0.9-0.9-0.1-0.5
Condit. Reinf. lever reinforcers received0.50.71.01.00.41.0-0.9-0.8-0.8-1.00.8-1.0-1.0-1.00.60.6
Conditioned reinforcement - actives0.60.62.10.7-0.70.7-0.6-0.5-0.6-0.80.4-1.0-0.4-0.40.71.5
Conditioned reinforcement - inactives2.02.35.32.10.62.3-1.5-1.4-1.4-1.71.4-1.7-1.3-1.30.71.3
Conditioned locomotion0.10.20.90.6-0.50.50.10.10.1-0.3-0.0-0.40.00.0-0.10.9
Patch foraging indifference point 0 sec5.99.515.73.93.04.0-3.3-3.3-3.3-3.13.2-2.7-3.2-3.21.20.4
Patch foraging indifference point AUC4.55.28.1-2.4-1.4-2.22.82.82.82.4-2.52.22.42.3-1.6-0.7
Delay disc. indifference point, 0s delay1.92.13.11.61.41.7-1.4-1.5-1.4-1.51.7-1.3-1.7-1.80.70.2
Delay disc. indifference point, 16s delay0.10.10.40.0-0.30.00.30.30.30.2-0.50.20.60.60.00.2
Delay disc. indifference point, 2s delay0.80.93.80.72.00.7-0.7-0.9-0.8-0.51.1-0.2-1.0-1.0-0.3-1.2
Delay disc. indifference point, 24s delay0.40.30.7-0.7-0.1-0.60.40.50.50.6-0.70.70.80.8-0.4-0.5
Delay disc. indifference point, 4s delay0.60.61.1-0.60.5-0.50.70.50.60.9-0.81.01.01.0-0.8-1.0
Delay disc. indifference point, 8s delay0.10.10.60.40.10.50.00.00.00.1-0.20.10.80.7-0.00.1
Indifference point function ln k1.72.43.91.81.41.7-2.0-1.9-1.9-1.51.5-1.3-1.6-1.40.80.1
Indifference point function log k1.72.43.91.81.41.7-2.0-1.9-1.9-1.51.5-1.3-1.6-1.40.80.1
Patch foraging total patch changes 0 sec5.38.514.73.83.13.8-3.2-3.2-3.2-2.93.0-2.5-3.0-3.01.00.2
Patch foraging total patch changes 12 sec0.70.92.21.11.31.5-0.9-0.9-1.0-0.91.0-0.7-1.0-1.00.2-0.1
Patch foraging total patch changes 18 sec0.40.51.91.10.41.4-0.5-0.6-0.7-0.80.3-0.8-0.5-0.40.60.7
Patch foraging total patch changes 24 sec1.31.54.21.52.01.7-1.1-1.3-1.3-1.01.0-0.7-1.2-1.2-0.2-0.6
Patch foraging total patch changes 6 sec0.30.41.10.90.71.1-0.7-0.6-0.6-0.60.6-0.5-0.5-0.50.40.1
Patch foraging time to switch 0 sec0.81.32.00.50.20.9-1.3-1.4-1.4-1.21.4-1.2-1.2-1.21.40.7
Patch foraging water rate 0 sec0.20.41.40.10.80.10.40.50.40.6-0.50.70.20.3-1.2-1.0
Patch foraging water rate 12 sec0.20.31.40.41.20.6-0.4-0.2-0.30.10.20.3-0.1-0.1-0.6-0.9
Patch foraging water rate 18 sec2.02.74.7-0.90.4-1.01.51.61.61.9-1.82.01.91.9-2.2-1.7
Patch foraging water rate 24 sec0.50.71.4-0.5-1.0-0.60.80.80.80.8-1.20.61.11.2-0.20.3
Patch foraging water rate 6 sec0.71.13.50.11.60.00.50.50.60.9-0.61.20.60.6-1.8-1.9
Seeking ratio, delayed vs. immediate footshock1.72.03.91.81.42.0-1.3-1.4-1.4-1.51.4-1.3-1.6-1.60.30.2
Distance traveled before self-admin0.60.62.6-0.41.3-0.30.40.40.40.7-0.41.00.30.5-0.9-1.6
Distance traveled after self-admin1.21.32.0-0.90.3-0.91.21.41.31.3-1.01.40.91.0-1.3-1.3
Extensor digitorum longus weight7.027.544.0-5.21.4-5.04.94.94.96.1-4.96.64.64.6-6.5-6.6
Bone: elastic displacement1.51.72.91.51.71.7-1.4-1.3-1.3-1.11.3-0.9-1.5-1.50.1-0.4
Bone: elastic work2.53.26.92.32.62.3-1.8-1.9-1.8-1.51.8-1.1-1.9-1.8-0.2-0.7
Bone: endosteal estimation0.20.40.90.50.60.9-0.7-0.7-0.7-0.60.8-0.5-0.6-0.60.2-0.0
Bone: endosteal perimeter0.71.42.11.11.31.4-1.3-1.3-1.3-1.11.4-0.9-1.4-1.40.2-0.2
Epididymis fat weight0.61.53.01.3-0.41.2-1.1-1.0-1.1-1.41.0-1.6-0.9-1.01.51.7
Delta time in closed arm before/after self-admin0.10.10.40.60.00.3-0.1-0.1-0.1-0.40.0-0.5-0.3-0.30.20.6
Delta time in open arm before/after self-admin0.20.20.8-0.3-0.90.2-0.0-0.1-0.1-0.20.1-0.4-0.2-0.20.60.7
Diff in mean of infusions in LGA sessions0.30.31.6-0.40.9-0.50.10.10.00.4-0.00.6-0.0-0.2-0.7-1.3
Delay discount exponential model param0.20.20.5-0.1-0.6-0.2-0.3-0.2-0.2-0.40.3-0.5-0.7-0.70.50.5
Extinction: sum of active levers before priming1.61.62.91.4-0.61.4-1.1-0.8-1.1-1.41.1-1.6-1.1-1.11.61.7
Active lever presses in extinction session 60.30.31.1-0.1-1.0-0.1-0.10.1-0.0-0.30.2-0.40.20.30.91.0
Bone: final force0.00.10.10.30.40.4-0.3-0.2-0.2-0.10.30.00.20.1-0.2-0.2
Bone: final moment0.20.30.80.80.90.9-0.7-0.7-0.7-0.40.7-0.2-0.1-0.2-0.1-0.3
Food consumed during 24 hour testing period0.40.52.81.70.81.4-0.3-0.3-0.3-0.4-0.1-0.30.20.2-0.60.1
Glucose1.21.83.9-1.0-2.0-1.01.51.41.41.1-1.60.81.71.7-0.20.8
Heart weight0.20.31.41.20.41.1-0.2-0.3-0.2-0.4-0.1-0.40.00.00.00.4
Delay discount hyperbolic model param0.30.30.8-0.1-0.9-0.2-0.3-0.2-0.2-0.40.3-0.6-0.6-0.60.70.9
Intermittent access intake day 1-15 change0.30.30.70.8-0.20.7-0.3-0.2-0.3-0.60.5-0.7-0.5-0.50.40.7
Intermittent access intake escalation0.10.10.20.3-0.30.20.10.10.1-0.20.2-0.3-0.2-0.20.10.4
Intermittent access intake escalation 20.00.00.10.4-0.10.20.00.00.0-0.20.1-0.2-0.2-0.20.10.2
Intermitt. access day 1 inactive lever presses0.10.20.6-0.3-0.6-0.1-0.2-0.1-0.2-0.20.5-0.3-0.4-0.40.80.5
Intermitt. access day 15 inactive lever presses0.10.10.2-0.1-0.0-0.10.30.40.40.2-0.20.20.30.3-0.3-0.1
Intermitt. access escalation Index0.10.10.3-0.5-0.2-0.50.10.10.20.30.10.20.10.10.0-0.3
Intermittent access day 1 total infusions0.50.61.70.0-0.30.10.70.90.80.7-1.30.61.21.2-0.80.2
Intermittent access day 15 total infusions0.30.30.80.0-0.90.10.50.70.60.3-0.70.10.60.6-0.20.7
Intermittent access terminal intake (last 3 days)1.01.12.1-0.5-0.9-0.41.21.31.21.0-1.50.91.41.4-0.80.1
Intermittent access total infusions0.50.61.3-0.1-1.1-0.00.70.90.80.5-1.10.31.01.0-0.00.8
Intermittent access day 1 locomotion0.40.41.51.20.61.2-0.5-0.3-0.5-0.60.1-0.5-0.2-0.20.10.6
Intermittent access day 15 total locomotion0.30.31.00.7-0.60.80.30.40.3-0.0-0.7-0.20.70.7-0.11.0
Intermittent access total locomotion0.20.21.51.00.31.2-0.10.1-0.1-0.2-0.2-0.20.20.2-0.10.5
Intermittent access standard deviation0.30.30.60.5-0.10.40.70.70.60.3-0.60.20.60.6-0.70.1
Left kidney weight0.41.13.30.81.10.40.90.80.80.8-1.11.01.31.2-1.8-1.0
Right kidney weight0.92.57.62.82.42.6-1.3-1.4-1.3-1.41.0-1.1-1.0-1.0-0.4-0.1
Cocaine induced anxiety0.91.04.40.92.11.0-1.0-0.9-1.0-0.40.9-0.0-0.7-0.7-0.6-1.3
Post-drug Anxiety2.83.14.71.50.51.6-2.2-2.1-2.1-1.91.9-1.8-1.9-1.91.80.9
Baseline Anxiety2.12.24.21.2-0.71.3-1.4-1.5-1.4-1.61.4-1.8-1.4-1.42.01.8
Tail length1.13.36.92.61.12.6-1.9-1.7-1.8-2.01.5-1.9-1.6-1.61.21.2
Length with tail0.51.75.41.72.31.6-1.5-1.4-1.3-1.01.2-0.6-1.1-1.1-0.2-0.8
Length without tail0.81.87.8-0.62.2-0.80.30.30.41.2-0.51.60.60.6-2.2-2.8
Times rat made contact with spout0.20.20.90.6-0.70.20.20.20.2-0.1-0.3-0.30.30.30.11.0
Lifetime Intake0.20.30.70.4-0.50.50.40.70.50.2-0.80.10.70.7-0.20.6
Liver weight, left2.94.67.1-1.5-0.3-1.72.32.22.22.3-2.42.42.62.7-2.5-1.5
Liver weight, right1.72.94.2-1.3-0.4-1.61.71.81.81.9-2.01.91.81.8-2.1-1.3
Locomotor activity2.23.414.91.93.91.9-1.7-1.6-1.6-0.81.7-0.1-1.2-1.3-1.4-2.3
Locomotor testing distance5.28.713.93.23.73.5-3.3-3.3-3.3-2.73.5-2.1-3.2-3.20.5-0.8
Locomotor testing rearing8.312.817.53.74.24.1-4.0-4.0-3.9-3.44.1-2.8-4.1-4.10.9-0.6
Locomotion in novel chamber0.10.10.50.70.20.3-0.2-0.1-0.1-0.1-0.1-0.10.30.40.10.2
Locomotion in novel chamber post-restriction1.11.32.5-0.8-0.0-1.01.41.61.51.2-1.01.20.80.8-1.4-0.8
Fecal boli incidents, locomotor time 10.60.62.50.00.3-0.20.50.50.50.7-0.60.81.61.6-0.8-0.6
Change in fecal boli incidents, locomotor task0.20.21.1-1.0-0.8-0.90.20.10.20.30.00.2-0.3-0.20.5-0.1
Time >=10cm from walls, locomotor time 11.31.42.31.50.51.4-1.0-1.1-1.1-1.31.4-1.3-1.3-1.20.80.8
Bouts of movement, locomotor time 12.12.23.5-1.6-0.3-1.61.91.81.71.7-1.31.70.90.9-1.8-1.4
Total resting periods, locomotor time 13.33.65.8-2.2-1.0-2.22.42.22.32.1-1.82.01.41.4-1.7-1.2
Rest time, locomotor task time 13.23.65.6-2.4-1.4-2.42.32.22.22.0-1.91.91.41.5-1.4-0.9
Distance moved, locomotor task time 12.32.54.51.50.81.8-2.1-1.8-1.9-1.71.6-1.6-1.3-1.41.60.9
Vertical activity count, locomotor time 11.92.06.01.42.41.3-1.9-1.5-1.6-1.01.4-0.7-1.2-1.30.0-1.0
Time >=10cm from walls, locomotor time 20.10.10.4-0.30.3-0.60.10.20.10.20.10.30.20.1-0.3-0.5
Bouts of movement, locomotor time 22.42.65.0-2.2-1.1-2.21.81.51.61.8-1.71.71.41.4-0.9-1.0
Total resting periods, locomotor time 24.14.47.0-2.6-1.5-2.62.32.12.12.3-2.42.12.12.1-1.2-1.0
Rest time, locomotor task time 27.18.213.2-2.4-2.2-2.53.43.33.33.0-3.62.73.33.4-2.0-0.6
Distance moved, locomotor task time 24.65.48.02.31.72.5-2.8-2.7-2.7-2.52.5-2.2-2.3-2.51.80.7
Vertical activity count, locomotor time 23.03.27.31.72.71.6-2.3-2.1-2.1-1.52.0-1.1-1.7-1.90.4-0.9
Light reinforcement 11.01.85.51.4-1.41.2-0.9-1.0-1.0-1.40.6-1.8-0.6-0.71.82.3
Light reinforcement 21.01.46.5-0.7-2.6-0.60.80.90.90.4-1.20.01.21.20.91.7
Bone: marrow area0.20.51.10.60.61.0-0.8-0.8-0.8-0.70.9-0.6-0.7-0.60.30.1
Bone: maximum diameter0.20.41.0-0.20.3-0.30.60.60.60.6-0.60.70.60.6-1.0-0.7
Bone: maximum force0.10.20.90.40.90.6-0.4-0.3-0.30.00.40.20.20.1-0.6-0.8
Bone: maximum moment0.40.72.11.01.41.2-0.9-0.8-0.9-0.40.9-0.2-0.2-0.3-0.4-0.7
Mean time between licks in bursts2.73.85.71.6-0.01.9-2.1-2.0-2.1-2.21.5-2.3-2.2-2.22.41.8
Mean num. licks in bursts0.10.21.01.00.50.4-0.3-0.3-0.2-0.40.0-0.3-0.1-0.1-0.30.2
Cd content in liver0.30.40.80.80.50.9-0.6-0.7-0.7-0.70.6-0.6-0.4-0.40.50.3
Co content in liver2.93.45.3-2.3-0.7-2.11.92.02.02.1-1.92.01.71.7-1.5-1.3
Cu content in liver1.21.52.1-1.2-0.5-1.41.31.41.41.3-1.31.31.21.2-1.1-0.8
Fe content in liver0.50.62.10.9-0.60.5-0.5-0.4-0.4-0.90.5-1.1-0.5-0.51.01.4
K content in liver0.20.20.80.2-0.50.3-0.2-0.2-0.2-0.40.2-0.6-0.5-0.50.70.9
Mg content in liver0.20.20.90.4-0.60.2-0.0-0.0-0.0-0.40.0-0.6-0.5-0.50.40.9
Mn content in liver1.92.13.31.50.01.5-1.3-1.3-1.3-1.71.3-1.8-1.7-1.71.51.5
Na content in liver1.71.89.91.43.10.7-0.7-0.6-0.7-0.10.70.4-0.7-0.7-1.7-2.2
Rb content in liver0.20.31.5-0.3-1.2-0.20.40.40.50.1-0.4-0.10.40.40.60.9
Se content in liver3.54.36.52.22.42.4-2.2-2.2-2.2-2.02.2-1.7-2.5-2.50.6-0.2
Sr content in liver0.50.51.20.50.00.1-0.6-0.6-0.6-0.80.6-0.8-1.1-1.10.60.5
Zn content in liver0.60.73.80.62.00.2-0.3-0.4-0.30.00.30.4-0.4-0.4-1.2-1.6
Bone: minimum diameter0.40.72.61.11.61.1-0.8-0.7-0.7-0.50.9-0.2-0.3-0.4-0.6-0.7
Time in familiar zone, hab. session 10.10.10.3-0.1-0.50.1-0.2-0.2-0.1-0.30.4-0.3-0.3-0.30.60.5
Time in novel zone, hab. session 12.22.12.7-1.4-0.3-1.61.51.41.51.6-1.71.61.71.7-1.4-1.1
Total zone transitions, hab. session 10.20.31.40.61.20.5-0.4-0.4-0.4-0.20.5-0.1-0.6-0.6-0.6-0.7
Total locomotion distance, hab. session 10.91.32.11.41.41.2-1.2-1.2-1.2-1.11.3-0.9-1.4-1.40.1-0.3
Locomotion velocity, hab. session 12.43.34.82.12.02.0-2.0-1.9-2.0-1.72.0-1.5-2.2-2.20.4-0.2
Time in familiar zone, hab. session 21.01.13.8-1.9-1.7-1.30.60.80.81.0-0.80.80.80.80.40.1
Time in novel zone, hab. session 20.60.61.91.21.40.9-0.4-0.7-0.6-0.70.6-0.5-0.6-0.6-0.3-0.2
Total zone transitions, hab. session 20.60.83.8-0.02.00.1-0.1-0.1-0.10.30.20.6-0.5-0.5-1.3-1.8
Total locomotion distance, hab. session 20.30.41.60.21.30.3-0.4-0.4-0.4-0.20.50.0-0.7-0.7-0.5-0.9
Locomotion velocity, hab. session 20.40.52.60.21.60.3-0.4-0.3-0.4-0.10.40.2-0.7-0.7-0.8-1.3
Novel to familiar place preference ratio1.01.01.71.10.81.2-1.1-1.3-1.3-1.01.2-0.9-0.8-0.80.50.1
Novelty place preference1.11.22.01.10.91.2-1.2-1.4-1.4-1.11.4-0.9-1.0-1.00.60.1
Time in novel zone, NPP test0.91.01.70.91.01.1-1.1-1.3-1.2-0.91.3-0.8-1.0-1.00.4-0.2
Total zone transitions, NPP test1.01.53.01.31.31.1-1.2-1.2-1.2-1.21.3-1.1-1.7-1.70.2-0.0
Total locomotion distance, NPP test4.56.19.32.61.22.3-2.6-2.6-2.6-2.82.7-2.7-3.0-3.01.81.3
Locomotion velocity, NPP test3.75.37.32.51.02.2-2.4-2.4-2.4-2.62.5-2.5-2.7-2.71.71.4
Intraocular pressure1.01.52.20.90.31.1-1.3-1.3-1.3-1.31.3-1.3-1.5-1.51.30.8
Delta distance traveled before/after self-admin1.51.62.5-1.6-0.9-1.41.41.51.41.4-1.21.31.11.1-1.2-0.6
Delta ambulatory time before/after self-admin1.11.31.9-1.4-0.6-1.21.31.31.31.2-1.01.11.00.9-1.2-0.7
Parametrial fat weight2.24.29.11.2-1.21.4-2.1-1.8-2.0-2.31.9-2.5-1.9-1.93.02.6
Pavlov. Cond. lever latency0.50.72.1-1.3-1.5-1.00.90.80.90.6-0.80.30.30.30.30.5
Pavlov. Cond. magazine entry latency0.10.10.70.90.20.4-0.2-0.2-0.1-0.20.1-0.20.20.2-0.10.3
Pavlov. Cond. change in total contacts0.80.94.20.72.00.3-0.1-0.1-0.10.40.10.70.40.4-1.6-1.7
Pavlov. Cond. index score0.20.31.31.01.10.6-0.2-0.2-0.2-0.10.20.10.20.2-0.8-0.6
Pavlov. Cond. latency score0.30.41.51.21.20.9-0.5-0.5-0.4-0.30.5-0.10.00.0-0.6-0.5
Pavlov. Cond. lever contacts0.40.41.71.31.30.8-0.4-0.4-0.4-0.30.4-0.1-0.0-0.0-0.6-0.5
Pavlov. Cond. magazine entry number0.20.31.1-0.4-0.7-0.0-0.3-0.3-0.3-0.40.3-0.5-0.6-0.61.00.7
Pavlov. Cond. intertrial magazine entries1.41.72.31.41.51.3-1.5-1.5-1.5-1.31.3-1.1-1.4-1.40.6-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.31.30.81.10.40.00.00.10.2-0.00.30.40.4-1.1-0.8
Pavlov. Cond. response bias0.30.41.20.50.7-0.00.40.40.40.5-0.40.60.80.8-1.1-0.6
Pavlov. Cond. lever latency0.50.73.0-0.4-1.7-0.5-0.1-0.1-0.1-0.40.2-0.7-0.3-0.41.31.5
Pavlov. Cond. magazine entry latency0.40.51.81.21.31.1-0.6-0.6-0.6-0.40.2-0.3-0.2-0.2-0.3-0.3
Pavlov. Cond. change in total contacts0.91.24.1-0.11.70.20.40.50.51.0-0.81.30.80.8-1.9-2.0
Pavlov. Cond. index score0.50.73.90.72.00.8-0.2-0.2-0.20.2-0.10.50.10.1-1.3-1.4
Pavlov. Cond. latency score0.60.74.21.02.01.0-0.5-0.4-0.4-0.10.10.2-0.2-0.2-1.1-1.3
Pavlov. Cond. lever contacts0.70.95.10.82.31.0-0.4-0.4-0.40.10.20.5-0.1-0.1-1.3-1.7
Pavlov. Cond. magazine entry number0.50.61.7-1.3-1.2-1.20.80.80.80.6-0.50.50.50.60.10.2
Pavlov. Cond. intertrial magazine entries5.06.69.82.1-0.42.2-2.5-2.4-2.5-2.92.8-3.1-2.7-2.73.02.7
Pavlov. Cond. lever-magazine prob. diff.0.50.63.30.51.80.6-0.1-0.0-0.00.3-0.30.60.20.2-1.3-1.4
Pavlov. Cond. response bias0.71.05.60.92.41.0-0.4-0.4-0.40.10.20.5-0.1-0.1-1.3-1.7
Time in closed arm before self-admin0.60.71.3-1.2-0.0-1.10.80.60.70.9-0.81.00.50.5-0.8-1.0
Time in closed arm after self-admin0.10.10.4-0.30.5-0.4-0.1-0.2-0.10.10.10.2-0.2-0.2-0.1-0.6
Time in open arm before self-admin0.20.20.60.30.60.0-0.7-0.6-0.7-0.40.8-0.3-0.5-0.40.4-0.2
Time in open arm after self-admin0.20.20.70.1-0.70.4-0.2-0.1-0.2-0.30.2-0.5-0.2-0.20.70.8
Bone: periosteal estimation0.20.41.20.70.71.1-0.7-0.7-0.7-0.60.7-0.4-0.3-0.40.0-0.0
Bone: periosteal perimeter0.40.71.30.90.81.2-0.9-0.9-0.9-0.80.9-0.7-0.9-0.90.1-0.0
Bone: post-yield work0.91.22.9-0.9-1.7-0.81.01.01.00.8-1.00.61.71.60.20.8
Progressive ratio test 1 active lever presses1.92.03.3-1.2-1.6-0.91.71.71.61.4-1.81.11.81.8-0.70.3
Progressive ratio test 1 breakpoint2.12.13.6-1.3-1.9-0.91.71.71.61.3-1.81.01.81.8-0.60.5
Progressive ratio test 1 inactive lever presses0.50.51.40.2-1.00.8-0.6-0.5-0.6-0.60.5-0.8-0.3-0.31.01.2
Progressive ratio test 2 active lever presses1.21.32.6-0.1-1.20.11.31.41.20.8-1.60.61.61.6-0.60.8
Progressive ratio test 2 breakpoint0.91.12.30.3-0.90.51.21.31.10.7-1.50.51.51.5-0.70.8
Progressive ratio test 2 inactive lever presses0.20.31.10.8-0.11.00.20.30.2-0.0-0.5-0.10.50.5-0.40.7
Incentive Sensitization - Responses0.40.41.81.30.51.30.10.20.2-0.1-0.5-0.10.50.5-0.80.4
Incentive Sensitization - Breakpoint0.50.52.41.50.61.60.00.10.1-0.3-0.4-0.30.40.4-0.70.5
Sum of active levers in priming session hrs 5-60.50.52.7-0.6-1.6-0.4-0.00.20.0-0.1-0.0-0.30.20.21.21.2
Progressive ratio0.30.41.50.00.6-0.10.60.70.60.6-0.30.70.40.4-1.2-0.8
Food seeking constrained by brief footshock3.74.58.0-2.8-2.4-2.82.32.52.42.1-2.51.81.71.7-0.7-0.1
Seeking ratio, punishment vs. effort0.81.02.2-1.5-1.5-1.40.91.01.00.8-1.30.60.80.80.20.4
Retroperitoneal fat weight0.20.62.40.3-1.20.2-0.2-0.3-0.3-0.70.4-0.9-0.3-0.31.21.5
Reaction time number correct0.20.31.7-1.3-1.0-0.60.30.40.40.5-0.40.50.30.30.3-0.0
Reaction time mean minus median0.20.21.00.11.0-0.2-0.4-0.5-0.5-0.20.3-0.0-0.5-0.5-0.3-0.7
Reaction time mean minus median AUC0.10.10.30.10.6-0.1-0.2-0.4-0.3-0.20.0-0.1-0.3-0.4-0.1-0.3
Reaction time num false alarms0.40.61.10.60.60.5-1.1-0.8-0.9-0.71.0-0.6-0.9-0.90.6-0.0
Reaction time num false alarms AUC0.20.30.70.50.50.3-0.9-0.6-0.7-0.50.8-0.4-0.4-0.40.4-0.1
Reaction time trials correct on left0.20.31.7-1.3-1.0-0.60.30.40.40.5-0.40.50.30.30.3-0.0
Reaction time trials on left0.20.31.6-1.3-1.0-0.50.20.30.30.5-0.30.40.30.30.40.1
Reaction time mean0.10.10.4-0.20.5-0.40.30.20.30.3-0.40.40.20.1-0.6-0.6
Reaction time mean AUC0.10.20.7-0.20.8-0.40.20.00.10.3-0.20.40.1-0.0-0.7-0.8
Median of all reaction times0.10.20.3-0.30.2-0.30.40.40.50.4-0.50.50.50.4-0.6-0.4
Reaction time omissions1.41.93.00.8-0.30.8-1.5-1.7-1.6-1.71.4-1.7-1.4-1.41.51.3
Reaction time false alarm rate0.20.31.01.00.60.4-0.7-0.5-0.6-0.60.7-0.5-0.4-0.40.30.1
Reaction time premature initiation rate0.71.01.5-0.9-0.2-0.81.01.21.21.2-1.11.10.70.8-1.2-0.8
Reaction time premature initiations1.01.42.6-1.6-0.7-1.11.11.41.41.4-1.31.31.01.0-0.9-0.8
Std. dev. reaction times0.10.10.3-0.10.6-0.30.1-0.10.00.1-0.30.20.1-0.0-0.4-0.5
Reaction time trials completed0.20.31.6-1.3-1.0-0.50.20.30.30.5-0.30.40.30.30.40.1
Reaction time trials AUC0.20.31.4-1.2-1.0-0.50.20.30.30.5-0.30.40.30.20.40.0
Run reversals in cocaine runway, females0.70.61.91.3-0.31.1-0.3-0.3-0.3-0.90.3-1.1-0.7-0.70.41.4
Run reversals in cocaine runway, males4.84.610.2-1.00.7-1.22.42.42.42.4-1.92.52.12.1-3.2-2.3
Latency to leave start box in cocaine runway1.51.62.5-1.30.1-1.41.31.41.41.4-1.41.50.80.9-1.6-1.3
Latency to leave start box in cocaine runway, F2.32.64.6-1.70.4-1.51.51.61.61.8-1.41.91.31.4-2.1-1.9
Latency to leave start box in cocaine runway, M0.40.41.00.7-0.00.5-0.4-0.6-0.5-0.70.1-0.8-1.0-1.00.60.7
Std. dev. time between licks in bursts6.67.811.62.61.73.2-3.0-3.1-3.1-3.02.8-2.8-3.4-3.42.01.0
Total sessions with >9 infusions0.20.20.50.1-0.70.5-0.2-0.1-0.2-0.30.1-0.4-0.3-0.30.70.7
Short access day 1 total inactive lever presses0.91.02.30.4-0.30.41.21.21.30.7-1.50.61.41.4-1.10.6
Short access day 10 total inactive lever presses0.30.41.5-0.3-1.2-0.2-0.2-0.2-0.1-0.40.5-0.6-0.3-0.31.11.0
Short access day 1 total infusions0.50.61.1-0.6-0.6-0.30.81.00.90.8-1.10.70.90.9-0.30.0
Short access day 10 total infusions0.30.31.10.70.70.90.20.40.20.3-0.70.40.50.5-1.1-0.4
Short access total infusions0.20.20.80.70.10.90.30.50.30.2-0.60.20.50.5-0.50.2
Short access day 1 locomotion0.20.20.90.40.90.6-0.3-0.1-0.3-0.00.10.1-0.1-0.1-0.2-0.6
Short access day 10 total locomotion0.80.92.01.40.81.4-0.9-0.8-0.9-1.00.9-0.9-0.8-0.80.40.6
Short access total locomotion0.91.02.61.40.81.6-1.0-0.9-1.0-1.00.8-1.0-0.9-0.90.40.5
One hour access (0.3 mA shock)0.10.20.50.7-0.10.60.10.30.10.0-0.6-0.00.50.5-0.40.4
Compulsive drug intake0.50.51.10.30.60.1-1.0-1.0-1.0-0.70.8-0.5-0.8-0.80.7-0.1
One hour access (shock baseline)0.50.61.3-0.1-0.30.11.01.00.90.7-1.10.70.90.9-0.90.0
Social response proportion1.01.14.4-1.3-2.1-1.50.90.90.90.6-1.00.20.60.70.71.0
Social responses2.83.67.61.1-1.41.2-1.7-1.6-1.6-2.01.6-2.4-2.0-2.02.82.5
Social time1.11.52.51.61.11.3-1.3-1.3-1.3-1.31.3-1.2-1.3-1.20.50.4
Soleus weight0.72.13.8-1.9-0.6-1.91.41.41.41.6-1.41.61.21.2-1.2-1.2
Bone: stiffness0.30.40.7-0.6-0.2-0.60.60.70.70.7-0.60.70.80.7-0.7-0.5
Tibialis anterior weight4.515.326.7-3.71.3-3.53.53.63.64.5-3.45.03.43.3-5.1-5.2
Time to tail flick, vehicle, before self-admin0.50.51.21.10.60.7-0.8-0.7-0.8-0.80.6-0.7-0.5-0.40.40.3
Time to tail flick, vehicle, after self-admin2.52.77.1-2.7-0.7-2.61.51.61.51.8-1.31.81.01.1-1.0-1.5
Time to tail flick, test, before self-admin0.90.92.71.60.61.4-0.7-0.7-0.7-1.00.8-1.0-0.8-0.80.20.7
Time to tail flick, test, after self-admin2.72.89.20.3-2.30.5-1.0-1.1-1.0-1.50.9-2.0-1.2-1.13.03.0
Delta time to tail flick, vehicle, before/after SA1.61.63.8-2.0-1.5-1.71.31.21.21.3-1.21.11.11.1-0.3-0.3
Delta time to tail flick, test, before/after SA1.61.58.1-1.4-2.8-1.10.20.20.30.0-0.5-0.40.20.31.91.8
Tibia length2.77.815.43.92.83.7-3.0-3.0-3.0-2.83.0-2.4-2.5-2.60.80.3
Ambulatory time before self-admin0.30.31.30.21.20.20.10.30.20.4-0.20.60.30.3-0.6-1.1
Ambulatory time after self-admin1.61.83.2-1.00.7-1.01.31.61.41.5-1.11.71.01.1-1.7-1.8
Bone: tissue strength0.50.50.90.80.60.6-0.9-0.9-0.9-0.70.9-0.7-0.6-0.70.40.1
Total heroin consumption0.70.92.2-0.80.8-0.90.70.60.61.0-0.41.21.11.0-1.2-1.5
Bone: trabecular number1.82.94.11.6-0.21.8-1.7-1.7-1.7-1.91.6-2.0-1.7-1.61.91.8
Bone: trabecular spacing1.72.23.7-1.40.5-1.41.51.51.51.7-1.41.81.31.3-1.9-1.8
Bone: trabecular thickness0.91.12.11.30.41.4-1.2-1.2-1.2-1.11.2-1.1-0.8-0.80.80.7
Bone: trabecular tissue density0.50.71.9-0.70.7-0.50.60.50.50.9-0.61.10.90.8-1.1-1.4
Water consumed over 24 hours0.50.62.1-0.20.60.10.70.60.70.8-0.80.80.50.5-1.4-1.0
Number of responses in last shaping day0.50.52.00.71.41.1-0.5-0.6-0.7-0.30.2-0.1-0.4-0.4-0.6-0.8