Hub : Genes

Trim23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA NM_001100637.1 0.03 0.03 5.0e-04 0.03 0.02 0.03 0.03 2.2e-04 2.6e-03 5.4e-04 3.9e-04
2 Adipose alternative polyA XM_008760684.3 0.03 0.03 4.8e-04 0.03 0.02 0.03 0.03 2.1e-04 2.2e-03 5.1e-04 4.4e-04
3 Adipose isoform ratio NM_001100637.1 0.03 0.03 7.3e-04 0.03 0.02 0.02 0.02 3.7e-04 3.8e-03 1.0e-03 9.3e-04
4 Brain isoform ratio XM_008760683.3 0.04 0.05 2.9e-03 0.03 0.02 0.02 0.02 2.2e-03 3.9e-03 2.6e-03 3.5e-03
5 Liver isoform ratio XM_008760683.3 0.06 0.12 4.7e-03 0.03 0.01 0.02 0.02 7.9e-04 7.7e-03 5.0e-03 1.7e-03
6 PL alternative polyA XM_008760684.3 0.04 0.03 1.4e-04 0.03 0.02 0.03 0.03 1.5e-04 1.5e-03 1.9e-04 2.8e-04
7 PL isoform ratio NM_001100637.1 0.04 0.04 5.4e-05 0.04 0.03 0.03 0.03 7.1e-05 2.2e-04 1.1e-04 7.9e-04
8 PL alternative polyA NM_001100637.1 0.03 0.03 2.9e-04 0.03 0.02 0.03 0.03 4.8e-04 1.9e-03 4.4e-04 4.3e-04
9 PL isoform ratio XM_008760683.3 0.02 0.02 6.2e-03 0.01 0.02 0.01 0.01 1.8e-02 3.2e-03 3.3e-02 2.7e-02
10 Brain isoform ratio NM_001100637.1 0.06 0.05 6.9e-06 0.06 0.06 0.05 0.06 6.9e-06 3.1e-06 1.4e-05 6.8e-06
11 Liver gene expression Trim23 0.05 0.04 2.5e-05 0.03 0.04 0.04 0.04 1.1e-04 3.5e-05 6.8e-05 8.9e-05
12 pVTA gene expression Trim23 0.1 0.09 1.9e-04 0.08 0.07 0.07 0.07 3.5e-04 4.3e-04 4.0e-04 4.3e-04
13 BLA isoform ratio NM_001100637.1 0.07 0.06 7.1e-04 0.04 0.04 0.04 0.04 4.9e-03 2.0e-03 3.4e-03 2.7e-03
14 NAcc alternative polyA NM_001100637.1 0.02 0.02 1.4e-03 0.01 0.02 0.01 0.01 8.9e-03 2.5e-03 4.2e-02 8.5e-03
15 NAcc alternative polyA XM_008760684.3 0.03 0.02 1.1e-03 0.01 0.02 0.01 0.01 1.1e-02 2.2e-03 2.7e-02 1.0e-02
16 Brain alternative polyA XM_008760684.3 0.04 0.04 6.5e-05 0.04 0.04 0.04 0.04 1.0e-04 4.7e-05 1.3e-04 8.7e-05
17 Brain alternative polyA NM_001100637.1 0.05 0.04 5.9e-05 0.04 0.04 0.04 0.04 9.2e-05 4.5e-05 1.2e-04 8.2e-05
18 NAcc isoform ratio NM_001100637.1 0.02 0.02 4.8e-03 0.01 0.02 0 0.01 3.4e-02 5.5e-03 2.2e-01 2.9e-02
19 pVTA mRNA stability Trim23 0.08 0.08 3.0e-03 0.07 0.05 0.05 0.06 7.9e-04 3.0e-03 2.9e-03 1.8e-03
20 Adipose gene expression Trim23 0.08 0.09 8.6e-06 0.04 0.04 0.03 0.03 5.6e-05 5.3e-05 9.4e-05 1.3e-04
21 BLA alternative polyA NM_001100637.1 0.09 0.08 6.3e-04 0.06 0.03 0.06 0.01 4.7e-04 1.2e-02 5.1e-04 5.5e-02
22 BLA alternative polyA XM_008760684.3 0.09 0.08 6.3e-04 0.06 0.03 0.06 0.01 4.9e-04 1.4e-02 6.4e-04 6.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.71.21.51.2-1.21.2-1.2-1.2-1.01.0-1.01.0-1.0-1.01.1-1.1-1.01.01.1-1.1-1.1-1.1-1.11.1-1.1
Area under the delay curve0.40.40.9-0.50.5-0.50.50.50.7-0.70.8-0.80.80.8-1.00.80.8-0.7-0.70.70.70.40.5-0.10.1
BMI with tail1.75.76.32.4-2.42.4-2.4-2.4-2.32.3-2.42.3-2.3-2.32.2-2.4-2.42.42.4-2.4-2.4-2.4-2.52.5-2.5
BMI without tail0.30.71.11.0-1.01.0-1.0-1.0-0.90.9-0.80.7-0.7-0.70.7-0.7-0.70.70.7-0.7-0.7-0.8-0.80.8-0.8
Body weight1.87.68.0-2.72.7-2.72.72.72.8-2.82.8-2.82.82.8-2.82.82.8-2.8-2.82.82.82.82.7-2.62.6
Weight adjusted by age0.20.20.4-0.40.4-0.40.40.40.3-0.30.4-0.40.40.4-0.30.40.4-0.4-0.40.40.40.40.6-0.60.6
Bone surface0.00.10.20.3-0.30.3-0.3-0.3-0.10.1-0.10.2-0.2-0.20.1-0.2-0.20.20.2-0.2-0.2-0.2-0.30.5-0.5
Bone volume0.10.30.40.6-0.60.6-0.6-0.6-0.40.4-0.40.4-0.4-0.40.5-0.5-0.50.50.5-0.5-0.5-0.5-0.50.7-0.7
Breakpoint value in progressive ratio session2.42.64.31.2-1.21.2-1.2-1.2-1.51.5-1.61.7-1.7-1.71.7-1.7-1.71.71.7-1.7-1.8-1.6-1.82.1-2.1
Number of licking bursts3.44.04.22.0-2.02.0-2.0-2.0-2.12.1-2.02.0-2.0-2.02.0-2.0-2.02.02.0-2.0-2.0-1.9-2.02.0-2.0
Context. condit. distance diff. score1.62.02.3-1.41.4-1.41.41.41.5-1.51.5-1.51.51.5-1.51.41.4-1.4-1.41.41.41.31.3-1.01.0
Locomotion velocity, session 10.50.50.9-0.90.9-0.90.90.90.8-0.80.7-0.60.60.6-0.60.60.6-0.6-0.60.60.60.50.6-0.50.5
Locomotion distance, session 10.70.91.0-1.01.0-1.01.01.01.0-1.01.0-1.01.01.0-1.01.01.0-1.0-1.01.01.01.00.9-0.70.7
Locomotion velocity, session 24.35.05.6-2.42.4-2.42.42.42.2-2.22.2-2.22.22.2-2.22.22.2-2.2-2.22.22.22.22.2-2.22.2
Locomotion distance, session 20.70.91.2-1.11.1-1.11.11.11.1-1.11.0-1.01.01.0-1.01.01.0-1.0-1.01.00.90.90.9-0.70.7
Locomotion velocity, session 35.15.97.2-2.72.7-2.72.72.72.6-2.62.5-2.42.42.4-2.42.42.4-2.3-2.32.32.32.22.3-2.12.1
Locomotion distance, session 37.58.28.8-3.03.0-3.03.03.03.0-3.02.9-2.92.92.9-2.92.92.9-2.9-2.82.82.82.82.8-2.62.6
Stereotopy head waving bouts, day 30.20.30.8-0.50.5-0.50.50.50.4-0.40.5-0.50.50.5-0.40.50.5-0.5-0.50.50.50.90.7-0.70.7
Stereotopy head waving duration, day 30.00.00.10.0-0.00.0-0.0-0.0-0.20.2-0.10.2-0.2-0.20.3-0.1-0.10.10.1-0.1-0.10.20.0-0.10.1
Locomotion velocity, session 70.10.10.2-0.30.3-0.30.30.30.4-0.40.4-0.30.30.3-0.40.30.3-0.3-0.30.30.30.30.3-0.50.5
Locomotion distance, session 70.40.50.6-0.50.5-0.50.50.50.7-0.70.7-0.70.70.7-0.80.70.7-0.7-0.70.70.70.70.7-0.70.7
Stereotopy head waving bouts, day 70.00.00.2-0.00.0-0.00.00.0-0.10.1-0.10.3-0.2-0.30.4-0.2-0.20.20.2-0.2-0.20.0-0.0-0.10.1
Stereotopy head waving duration, day 70.10.10.2-0.30.3-0.30.30.30.2-0.20.2-0.20.20.2-0.00.20.2-0.2-0.20.20.20.40.3-0.50.5
Locomotion velocity, session 82.53.03.3-1.71.7-1.71.71.71.8-1.81.7-1.71.71.7-1.71.71.7-1.7-1.71.71.71.81.8-1.71.7
Locomotion distance, session 84.05.96.7-2.52.5-2.52.52.52.6-2.62.5-2.52.52.5-2.52.52.5-2.5-2.52.52.42.32.3-2.02.0
Degree of sensitization distance3.73.75.12.3-2.32.3-2.3-2.3-2.02.0-2.01.9-1.9-1.91.9-1.8-1.81.81.8-1.8-1.8-1.7-1.71.4-1.4
Degree of sensitization stereotypy0.00.00.10.0-0.00.0-0.0-0.0-0.00.0-0.10.2-0.2-0.20.3-0.2-0.20.20.2-0.2-0.2-0.2-0.10.0-0.0
Conditioned locomotion0.10.10.20.5-0.50.5-0.5-0.5-0.20.2-0.30.2-0.3-0.30.2-0.3-0.30.30.3-0.3-0.3-0.1-0.30.3-0.3
Cocaine response after cond. corrected1.51.71.7-1.31.3-1.31.31.31.3-1.31.3-1.31.31.3-1.31.31.3-1.3-1.31.31.31.31.3-1.31.3
Cocaine response after cond. not corrected2.12.42.5-1.61.6-1.61.61.61.6-1.61.6-1.61.51.6-1.61.51.5-1.5-1.51.51.51.51.5-1.41.4
Cocaine response before conditioning0.40.40.6-0.80.8-0.80.80.80.6-0.60.7-0.70.60.6-0.70.60.6-0.6-0.60.60.60.50.5-0.40.4
Saline control response1.31.72.7-1.61.6-1.61.61.61.4-1.41.3-1.21.21.2-1.21.21.2-1.2-1.21.21.21.11.1-1.01.0
Bone: connectivity density0.10.10.20.4-0.40.4-0.4-0.4-0.30.3-0.30.3-0.3-0.30.2-0.3-0.30.30.3-0.3-0.3-0.3-0.30.4-0.4
Bone: cortical apparent density0.10.10.3-0.10.1-0.10.10.10.3-0.30.3-0.30.40.3-0.30.40.4-0.4-0.40.40.40.30.4-0.50.5
Bone: cortical area0.10.10.4-0.10.1-0.10.10.10.3-0.30.3-0.30.30.3-0.20.30.3-0.3-0.30.30.40.60.4-0.50.5
Bone: cortical porosity1.71.93.01.7-1.71.7-1.7-1.7-1.31.3-1.31.4-1.4-1.41.5-1.3-1.31.31.3-1.3-1.3-0.9-1.10.7-0.7
Bone: cortical porosity1.71.92.91.7-1.71.7-1.7-1.7-1.31.3-1.31.4-1.4-1.41.5-1.3-1.31.31.3-1.3-1.3-0.8-1.10.8-0.8
Bone: cortical thickness0.10.20.60.0-0.00.0-0.0-0.00.2-0.20.3-0.30.30.3-0.20.40.4-0.4-0.40.40.40.70.6-0.80.8
Bone: cortical thickness0.81.01.1-0.90.9-0.90.90.91.0-1.01.0-1.01.01.0-1.01.01.0-1.0-1.01.01.00.91.0-1.01.0
Bone: cortical tissue density0.10.10.4-0.10.1-0.10.10.10.3-0.30.4-0.40.40.4-0.40.40.4-0.4-0.40.40.40.40.5-0.60.6
Condit. Reinf. active minus inactive responses1.92.12.91.7-1.71.7-1.7-1.7-1.61.6-1.51.5-1.4-1.41.5-1.4-1.41.41.4-1.4-1.3-0.9-1.10.8-0.8
Condit. Reinf. active-inactive response ratio1.82.02.61.6-1.61.6-1.6-1.6-1.61.6-1.51.4-1.4-1.41.5-1.4-1.41.41.4-1.4-1.3-0.9-1.20.9-0.9
Condit. Reinf. active responses0.30.30.60.8-0.80.8-0.8-0.8-0.70.7-0.60.6-0.6-0.60.7-0.5-0.50.50.5-0.5-0.5-0.1-0.40.2-0.2
Condit. Reinf. inactive responses1.21.41.6-1.21.2-1.21.21.21.3-1.31.2-1.21.21.2-1.21.21.2-1.2-1.21.21.21.11.1-1.01.0
Incentive salience index mean1.31.62.21.5-1.51.5-1.5-1.5-1.41.4-1.31.3-1.3-1.31.3-1.2-1.21.21.2-1.2-1.2-0.9-1.10.9-0.9
Condit. Reinf. lever presses0.40.50.60.8-0.80.8-0.8-0.8-0.70.7-0.70.7-0.7-0.70.7-0.7-0.70.70.7-0.7-0.7-0.7-0.70.7-0.7
Condit. Reinf. active minus inactive responses3.94.85.9-2.42.4-2.42.42.42.2-2.22.3-2.12.12.1-2.02.12.1-2.1-2.12.12.11.92.1-2.02.0
Condit. Reinf. active-inactive response ratio2.12.22.8-1.51.5-1.51.51.51.4-1.41.5-1.41.51.4-1.31.51.5-1.5-1.51.51.51.41.6-1.71.7
Condit. Reinf. active responses1.42.03.1-1.81.8-1.81.81.81.4-1.41.5-1.31.31.3-1.21.31.3-1.3-1.31.31.31.21.3-1.21.2
Condit. Reinf. inactive responses0.20.20.5-0.70.7-0.70.70.70.4-0.40.4-0.30.30.3-0.30.30.3-0.3-0.30.30.30.30.3-0.10.1
Condit. Reinf. lever presses1.82.53.0-1.71.7-1.71.71.71.6-1.61.7-1.51.51.5-1.51.51.5-1.5-1.51.51.51.61.5-1.31.3
Condit. Reinf. lever reinforcers received1.92.73.8-2.02.0-2.02.02.01.7-1.71.7-1.51.51.5-1.41.51.5-1.5-1.51.51.51.41.5-1.41.4
Conditioned reinforcement - actives3.43.45.3-2.32.3-2.32.32.31.9-1.91.7-1.71.71.7-1.61.71.7-1.7-1.71.71.71.81.7-1.61.6
Conditioned reinforcement - inactives0.30.30.8-0.60.6-0.60.60.60.3-0.30.4-0.40.50.4-0.30.50.5-0.5-0.50.50.50.90.6-0.70.7
Conditioned locomotion0.81.01.4-1.21.2-1.21.21.21.1-1.10.9-0.90.90.9-0.90.90.9-0.9-0.90.90.90.80.9-0.90.9
Patch foraging indifference point 0 sec4.26.79.5-2.42.4-2.42.42.42.3-2.32.5-2.62.62.6-2.62.72.6-2.7-2.72.72.73.12.8-2.72.7
Patch foraging indifference point AUC0.81.02.30.6-0.60.6-0.6-0.6-0.70.7-1.01.0-1.0-1.01.0-1.1-1.01.01.0-1.0-1.1-1.5-1.11.2-1.2
Delay disc. indifference point, 0s delay0.20.20.40.6-0.60.6-0.6-0.6-0.40.4-0.40.4-0.4-0.40.3-0.4-0.40.40.4-0.4-0.4-0.5-0.40.4-0.4
Delay disc. indifference point, 16s delay0.90.91.3-1.01.0-1.01.01.01.2-1.21.0-1.11.01.0-1.11.01.0-1.0-0.90.90.91.00.7-0.30.3
Delay disc. indifference point, 2s delay0.10.10.40.7-0.70.7-0.7-0.7-0.40.4-0.30.3-0.2-0.30.1-0.2-0.20.20.2-0.2-0.2-0.3-0.1-0.10.1
Delay disc. indifference point, 24s delay0.70.71.2-0.70.7-0.70.70.70.9-0.91.0-1.00.91.0-1.10.90.9-0.9-0.90.90.80.90.60.0-0.0
Delay disc. indifference point, 4s delay0.00.00.1-0.10.1-0.10.10.1-0.10.10.1-0.20.20.2-0.30.20.2-0.2-0.20.20.20.00.2-0.20.2
Delay disc. indifference point, 8s delay0.10.10.3-0.20.2-0.20.20.20.3-0.30.4-0.40.30.4-0.50.30.3-0.3-0.30.30.3-0.20.10.4-0.4
Indifference point function ln k4.25.88.3-2.22.2-2.22.22.22.2-2.22.4-2.52.52.5-2.52.52.5-2.5-2.52.52.52.92.5-2.52.5
Indifference point function log k4.25.88.3-2.22.2-2.22.22.22.2-2.22.4-2.52.52.5-2.52.52.5-2.5-2.52.52.52.92.5-2.52.5
Patch foraging total patch changes 0 sec5.18.211.2-2.62.6-2.62.62.62.7-2.72.8-2.92.92.9-2.92.92.9-2.9-2.92.92.93.33.1-3.03.0
Patch foraging total patch changes 12 sec0.00.00.1-0.00.0-0.00.00.0-0.10.1-0.10.0-0.0-0.0-0.1-0.0-0.00.00.0-0.0-0.0-0.2-0.10.2-0.2
Patch foraging total patch changes 18 sec0.00.00.10.3-0.30.3-0.3-0.3-0.10.1-0.10.0-0.0-0.0-0.10.00.0-0.0-0.00.00.00.10.1-0.10.1
Patch foraging total patch changes 24 sec0.60.70.9-0.60.6-0.60.60.60.8-0.80.8-0.90.90.9-0.90.90.9-0.9-0.90.90.90.81.0-0.90.9
Patch foraging total patch changes 6 sec0.81.11.5-0.90.9-0.90.90.90.8-0.80.9-1.11.11.1-1.21.11.1-1.1-1.21.21.11.11.2-1.21.2
Patch foraging time to switch 0 sec6.510.012.43.5-3.53.5-3.5-3.5-3.13.1-3.03.0-3.0-3.03.0-3.0-3.03.03.0-3.0-3.0-2.8-3.13.1-3.1
Patch foraging water rate 0 sec5.48.69.4-3.03.0-3.03.03.02.8-2.82.8-2.92.92.9-2.92.92.9-2.9-2.92.92.92.73.0-3.13.1
Patch foraging water rate 12 sec4.77.38.5-2.52.5-2.52.52.52.5-2.52.7-2.72.72.7-2.72.72.8-2.8-2.82.82.82.72.9-2.92.9
Patch foraging water rate 18 sec6.48.69.4-3.13.1-3.13.13.12.8-2.82.9-2.92.92.9-3.02.92.9-2.9-2.92.92.92.72.9-2.92.9
Patch foraging water rate 24 sec2.73.85.5-1.91.9-1.91.91.91.9-1.92.0-1.91.91.9-2.01.91.9-1.9-1.91.92.01.82.0-2.32.3
Patch foraging water rate 6 sec13.619.920.3-4.54.5-4.54.54.54.4-4.44.4-4.54.54.5-4.54.54.5-4.5-4.54.54.54.34.5-4.54.5
Seeking ratio, delayed vs. immediate footshock1.51.82.61.6-1.61.6-1.6-1.6-1.21.2-1.31.2-1.2-1.31.2-1.3-1.21.21.2-1.3-1.3-1.4-1.31.1-1.1
Distance traveled before self-admin1.92.02.8-1.11.1-1.11.11.11.3-1.31.5-1.51.51.5-1.61.51.5-1.5-1.51.51.51.71.5-1.41.4
Distance traveled after self-admin1.41.51.9-1.11.1-1.11.11.11.2-1.21.3-1.31.31.3-1.41.31.3-1.3-1.31.31.31.01.3-1.31.3
Extensor digitorum longus weight3.815.016.63.6-3.63.6-3.6-3.6-4.04.0-4.04.0-4.0-4.04.0-4.0-4.04.04.0-4.0-4.0-4.1-3.93.6-3.6
Bone: elastic displacement1.41.51.81.2-1.21.2-1.2-1.2-1.21.2-1.21.2-1.3-1.31.3-1.3-1.31.31.3-1.3-1.3-1.1-1.31.2-1.2
Bone: elastic work0.70.91.10.9-0.90.9-0.9-0.9-0.90.9-0.90.9-0.9-0.90.9-0.9-0.90.90.9-0.9-0.9-0.8-1.01.1-1.1
Bone: endosteal estimation0.20.50.8-0.90.9-0.90.90.90.7-0.70.8-0.80.70.7-0.80.70.7-0.7-0.70.70.70.60.6-0.30.3
Bone: endosteal perimeter0.00.00.20.1-0.10.1-0.1-0.1-0.10.1-0.10.1-0.1-0.10.0-0.1-0.10.10.1-0.1-0.1-0.0-0.20.4-0.4
Epididymis fat weight0.00.00.10.1-0.10.1-0.1-0.1-0.00.0-0.00.1-0.1-0.10.1-0.1-0.10.10.1-0.1-0.1-0.1-0.0-0.30.3
Delta time in closed arm before/after self-admin4.14.06.02.0-2.02.0-2.0-2.0-1.81.8-1.91.9-1.9-1.91.9-1.9-1.92.02.0-2.0-2.0-2.0-2.12.5-2.5
Delta time in open arm before/after self-admin0.00.00.00.0-0.00.0-0.0-0.00.0-0.0-0.00.1-0.1-0.10.0-0.1-0.10.10.1-0.1-0.10.1-0.00.1-0.1
Diff in mean of infusions in LGA sessions0.20.20.70.2-0.20.2-0.2-0.2-0.40.4-0.40.6-0.6-0.60.8-0.6-0.60.60.6-0.6-0.5-0.5-0.50.5-0.5
Delay discount exponential model param0.40.40.90.5-0.50.5-0.5-0.5-0.70.7-0.80.8-0.8-0.81.0-0.8-0.80.70.7-0.7-0.7-0.4-0.50.2-0.2
Extinction: sum of active levers before priming1.51.52.51.1-1.11.1-1.1-1.1-1.11.1-1.11.2-1.3-1.31.4-1.3-1.31.31.3-1.3-1.3-0.9-1.31.6-1.6
Active lever presses in extinction session 61.91.82.60.9-0.90.9-0.9-0.9-1.11.1-1.31.4-1.5-1.51.5-1.5-1.51.51.5-1.5-1.5-1.4-1.51.6-1.6
Bone: final force0.71.11.5-1.11.1-1.11.11.11.1-1.11.1-1.11.11.1-1.01.11.1-1.0-1.11.01.01.21.0-0.80.8
Bone: final moment0.91.42.0-1.21.2-1.21.21.21.2-1.21.2-1.21.21.2-1.11.21.2-1.2-1.21.21.21.41.2-1.01.0
Food consumed during 24 hour testing period0.91.01.4-0.90.9-0.90.90.91.0-1.01.0-1.01.01.0-1.01.01.0-1.0-1.01.01.01.11.1-1.21.2
Glucose0.81.21.81.1-1.11.1-1.1-1.1-1.41.4-1.21.2-1.2-1.21.2-1.1-1.11.11.1-1.1-1.1-0.8-0.90.6-0.6
Heart weight0.30.50.60.4-0.40.4-0.4-0.4-0.70.7-0.80.8-0.8-0.80.7-0.7-0.80.70.7-0.7-0.7-0.7-0.70.7-0.7
Delay discount hyperbolic model param0.30.30.70.4-0.40.4-0.4-0.4-0.50.5-0.60.7-0.6-0.70.8-0.6-0.60.60.6-0.6-0.6-0.3-0.50.2-0.2
Intermittent access intake day 1-15 change0.20.20.50.7-0.70.7-0.7-0.7-0.00.00.1-0.10.10.10.00.20.2-0.2-0.20.20.20.60.3-0.50.5
Intermittent access intake escalation0.20.20.50.5-0.50.5-0.5-0.50.1-0.10.2-0.20.20.2-0.10.30.3-0.3-0.30.30.30.70.5-0.70.7
Intermittent access intake escalation 20.20.21.01.0-1.01.0-1.0-1.0-0.00.0-0.10.1-0.1-0.10.3-0.1-0.10.10.1-0.1-0.10.1-0.0-0.10.1
Intermitt. access day 1 inactive lever presses2.83.03.51.9-1.91.9-1.9-1.9-1.81.8-1.91.8-1.8-1.81.7-1.7-1.71.71.7-1.7-1.7-1.4-1.71.5-1.5
Intermitt. access day 15 inactive lever presses3.43.74.82.2-2.22.2-2.2-2.2-2.02.0-1.91.9-1.9-1.91.9-1.9-1.91.91.8-1.8-1.8-1.5-1.81.8-1.8
Intermitt. access escalation Index0.70.61.8-1.31.3-1.31.31.30.6-0.60.7-0.50.50.5-0.50.40.4-0.4-0.40.40.40.40.4-0.20.2
Intermittent access day 1 total infusions1.71.94.5-2.12.1-2.12.12.11.3-1.31.1-1.01.01.0-1.01.01.0-1.0-1.01.01.01.41.0-1.01.0
Intermittent access day 15 total infusions1.82.14.8-1.51.5-1.51.51.51.3-1.31.3-1.21.31.3-1.11.31.3-1.3-1.31.31.32.21.5-1.71.7
Intermittent access terminal intake (last 3 days)1.01.12.3-1.21.2-1.21.21.21.0-1.00.9-0.90.90.9-0.80.90.9-0.9-0.90.90.91.51.0-1.11.1
Intermittent access total infusions2.62.94.6-2.12.1-2.12.12.11.6-1.61.5-1.41.51.4-1.41.51.5-1.5-1.51.51.52.11.6-1.71.7
Intermittent access day 1 locomotion3.23.45.3-2.32.3-2.32.32.31.9-1.91.7-1.61.61.6-1.61.61.6-1.6-1.61.61.62.01.7-1.81.8
Intermittent access day 15 total locomotion1.82.03.4-1.21.2-1.21.21.21.4-1.41.3-1.31.31.3-1.21.41.4-1.4-1.41.41.41.81.6-1.81.8
Intermittent access total locomotion5.15.87.8-2.52.5-2.52.52.52.4-2.42.2-2.22.32.3-2.32.32.3-2.3-2.32.32.32.82.5-2.62.6
Intermittent access standard deviation0.60.61.11.0-1.01.0-1.0-1.0-0.50.5-0.60.7-0.7-0.70.8-0.7-0.70.70.7-0.7-0.7-0.6-0.70.6-0.6
Left kidney weight1.13.03.5-1.91.9-1.91.91.91.8-1.81.8-1.71.71.7-1.61.71.7-1.7-1.71.71.71.61.7-1.61.6
Right kidney weight0.41.01.5-1.21.2-1.21.21.21.2-1.21.1-0.90.90.9-0.90.90.9-0.9-0.90.90.90.90.8-0.80.8
Cocaine induced anxiety1.01.22.1-1.41.4-1.41.41.41.0-1.01.0-1.11.11.1-1.21.01.0-1.0-1.01.01.00.90.8-0.50.5
Post-drug Anxiety1.61.72.9-1.71.7-1.71.71.71.2-1.21.2-1.31.31.3-1.31.21.2-1.2-1.21.21.20.81.1-0.80.8
Baseline Anxiety0.10.10.30.5-0.50.5-0.5-0.50.1-0.10.0-0.10.10.1-0.00.10.1-0.1-0.10.10.1-0.10.1-0.20.2
Tail length7.923.926.0-4.64.6-4.64.64.64.8-4.84.9-5.05.05.0-4.85.05.0-5.0-5.05.05.05.15.1-5.15.1
Length with tail12.144.445.6-6.66.6-6.66.66.66.7-6.76.7-6.76.76.7-6.56.76.7-6.7-6.76.76.76.76.8-6.66.6
Length without tail7.616.618.1-4.34.3-4.34.34.34.3-4.34.2-4.04.04.0-4.04.04.0-4.0-4.04.04.03.94.0-3.93.9
Times rat made contact with spout0.40.40.60.6-0.60.6-0.6-0.6-0.80.8-0.70.7-0.7-0.70.7-0.7-0.70.70.7-0.7-0.7-0.5-0.70.6-0.6
Lifetime Intake2.22.54.2-1.91.9-1.91.91.91.5-1.51.4-1.41.41.4-1.41.41.4-1.4-1.41.41.42.11.5-1.61.6
Liver weight, left0.40.72.4-0.90.9-0.90.90.90.6-0.60.5-0.50.60.6-0.50.60.6-0.7-0.70.70.71.01.0-1.61.6
Liver weight, right0.10.10.2-0.40.4-0.40.40.4-0.20.2-0.20.3-0.3-0.30.4-0.3-0.30.30.3-0.3-0.3-0.2-0.30.4-0.4
Locomotor activity0.30.50.9-0.90.9-0.90.90.90.9-0.90.7-0.70.70.7-0.90.70.7-0.7-0.70.70.70.50.5-0.40.4
Locomotor testing distance0.30.51.00.4-0.40.4-0.4-0.4-0.50.5-0.80.7-0.7-0.70.7-0.7-0.70.70.7-0.7-0.8-0.8-0.81.0-1.0
Locomotor testing rearing0.20.30.60.0-0.00.0-0.0-0.0-0.50.5-0.60.6-0.6-0.60.7-0.6-0.60.60.6-0.6-0.6-0.6-0.70.8-0.8
Locomotion in novel chamber1.11.41.91.3-1.31.3-1.3-1.3-1.11.1-1.11.0-1.0-1.01.0-1.1-1.01.01.0-1.0-1.0-1.2-1.11.4-1.4
Locomotion in novel chamber post-restriction0.10.10.3-0.20.2-0.20.20.2-0.30.3-0.30.2-0.2-0.2-0.0-0.2-0.20.20.2-0.2-0.3-0.4-0.40.6-0.6
Fecal boli incidents, locomotor time 11.92.03.30.9-0.90.9-0.9-0.9-1.21.2-1.31.5-1.6-1.61.6-1.6-1.61.61.6-1.6-1.6-1.3-1.71.8-1.8
Change in fecal boli incidents, locomotor task0.30.31.01.0-1.01.0-1.0-1.0-0.60.6-0.50.1-0.0-0.0-0.2-0.1-0.00.00.0-0.0-0.0-0.30.0-0.20.2
Time >=10cm from walls, locomotor time 12.02.02.91.5-1.51.5-1.5-1.5-1.71.7-1.51.4-1.4-1.41.4-1.4-1.41.31.4-1.4-1.3-1.1-1.31.3-1.3
Bouts of movement, locomotor time 10.30.40.50.3-0.30.3-0.3-0.3-0.60.6-0.60.6-0.7-0.70.7-0.7-0.70.70.7-0.7-0.7-0.6-0.70.7-0.7
Total resting periods, locomotor time 10.10.10.3-0.00.0-0.00.00.0-0.20.2-0.30.2-0.3-0.30.3-0.3-0.30.30.3-0.3-0.3-0.2-0.40.6-0.6
Rest time, locomotor task time 11.51.62.70.7-0.70.7-0.7-0.7-1.21.2-1.31.3-1.4-1.41.4-1.4-1.41.41.4-1.4-1.4-1.4-1.51.6-1.6
Distance moved, locomotor task time 11.71.83.6-0.70.7-0.70.70.71.2-1.21.4-1.41.41.4-1.51.41.5-1.5-1.51.51.51.41.6-1.91.9
Vertical activity count, locomotor time 11.31.33.0-0.50.5-0.50.50.51.0-1.01.1-1.21.31.3-1.41.21.3-1.3-1.31.31.30.81.3-1.71.7
Time >=10cm from walls, locomotor time 21.11.21.81.4-1.41.4-1.4-1.4-1.21.2-1.00.9-0.9-0.90.7-0.9-0.90.90.9-0.9-0.9-0.7-1.01.2-1.2
Bouts of movement, locomotor time 20.20.30.5-0.70.7-0.70.70.70.6-0.60.5-0.50.50.5-0.50.40.5-0.4-0.40.40.40.20.3-0.30.3
Total resting periods, locomotor time 20.00.00.1-0.20.2-0.20.20.20.1-0.10.00.0-0.0-0.00.0-0.1-0.10.10.1-0.1-0.1-0.3-0.20.2-0.2
Rest time, locomotor task time 23.43.95.31.5-1.51.5-1.5-1.5-2.02.0-2.02.1-2.2-2.12.3-2.1-2.12.12.2-2.2-2.1-1.8-2.12.1-2.1
Distance moved, locomotor task time 22.12.53.2-1.41.4-1.41.41.41.7-1.71.6-1.61.61.6-1.81.61.6-1.6-1.61.61.61.21.6-1.71.7
Vertical activity count, locomotor time 20.50.51.6-0.40.4-0.40.40.40.6-0.60.6-0.70.70.7-0.90.70.7-0.7-0.80.80.80.30.8-1.31.3
Light reinforcement 12.44.55.7-2.42.4-2.42.42.42.1-2.11.9-1.92.01.9-1.72.02.0-2.0-2.02.02.01.92.1-2.32.3
Light reinforcement 20.10.10.20.4-0.40.4-0.4-0.4-0.20.2-0.40.4-0.4-0.40.5-0.4-0.40.40.4-0.4-0.4-0.2-0.30.2-0.2
Bone: marrow area0.20.50.8-0.90.9-0.90.90.90.7-0.70.8-0.70.70.7-0.80.70.7-0.7-0.70.70.70.60.6-0.30.3
Bone: maximum diameter0.40.80.90.8-0.80.8-0.8-0.8-0.90.9-0.90.9-0.9-0.90.9-0.9-0.90.90.9-0.9-0.9-0.8-0.90.9-0.9
Bone: maximum force0.10.20.5-0.50.5-0.50.50.50.5-0.50.5-0.50.50.5-0.40.50.5-0.5-0.50.50.50.70.4-0.20.2
Bone: maximum moment0.30.40.9-0.60.6-0.60.60.60.7-0.70.7-0.70.70.7-0.60.70.7-0.7-0.70.70.70.90.6-0.40.4
Mean time between licks in bursts0.10.10.20.3-0.30.3-0.3-0.3-0.50.5-0.50.4-0.4-0.40.3-0.4-0.40.40.3-0.3-0.3-0.2-0.30.3-0.3
Mean num. licks in bursts2.22.62.9-1.61.6-1.61.61.61.6-1.61.6-1.61.61.6-1.61.61.6-1.6-1.61.61.61.61.6-1.71.7
Cd content in liver0.40.50.6-0.60.6-0.60.60.60.8-0.80.7-0.70.80.8-0.80.70.7-0.7-0.70.70.70.60.7-0.70.7
Co content in liver0.20.20.3-0.30.3-0.30.30.30.5-0.50.5-0.50.50.5-0.50.50.4-0.4-0.40.40.40.60.3-0.00.0
Cu content in liver0.20.30.7-0.50.5-0.50.50.50.4-0.40.5-0.40.40.4-0.30.50.4-0.5-0.50.50.50.90.6-0.70.7
Fe content in liver1.51.82.4-1.41.4-1.41.41.41.2-1.21.3-1.31.31.3-1.21.31.3-1.3-1.31.31.31.31.4-1.61.6
K content in liver3.13.03.9-1.91.9-1.91.91.92.0-2.01.8-1.81.81.8-1.91.71.7-1.7-1.71.71.71.21.5-1.11.1
Mg content in liver0.70.71.3-1.11.1-1.11.11.11.1-1.10.8-0.90.80.8-0.90.80.8-0.8-0.70.70.70.30.5-0.10.1
Mn content in liver0.40.40.5-0.70.7-0.70.70.70.7-0.70.7-0.60.60.6-0.60.60.6-0.6-0.60.60.60.60.6-0.70.7
Na content in liver0.30.30.4-0.50.5-0.50.50.50.6-0.60.6-0.50.50.5-0.50.50.5-0.5-0.50.50.50.60.5-0.40.4
Rb content in liver0.81.01.8-0.90.9-0.90.90.91.0-1.01.1-1.01.01.0-1.01.01.0-1.0-1.01.01.01.31.1-1.01.0
Se content in liver0.10.10.30.3-0.30.3-0.3-0.3-0.40.4-0.40.4-0.4-0.40.4-0.4-0.40.40.4-0.4-0.4-0.5-0.30.3-0.3
Sr content in liver2.32.13.61.3-1.31.3-1.3-1.3-1.31.3-1.41.4-1.4-1.41.3-1.4-1.41.51.5-1.5-1.5-1.4-1.61.9-1.9
Zn content in liver0.00.00.00.1-0.10.1-0.1-0.1-0.00.0-0.0-0.10.10.1-0.10.00.0-0.0-0.00.00.0-0.2-0.10.2-0.2
Bone: minimum diameter1.83.43.9-1.81.8-1.81.81.81.9-1.91.9-1.91.91.9-1.91.91.9-1.9-1.91.91.92.01.9-1.81.8
Time in familiar zone, hab. session 14.74.44.7-2.12.1-2.12.12.12.2-2.22.1-2.12.12.1-2.12.12.1-2.1-2.12.12.12.02.1-2.12.1
Time in novel zone, hab. session 16.66.46.72.6-2.62.6-2.6-2.6-2.62.6-2.52.5-2.5-2.52.6-2.5-2.52.52.5-2.5-2.5-2.4-2.52.5-2.5
Total zone transitions, hab. session 10.00.00.1-0.20.2-0.20.20.20.3-0.30.2-0.20.20.2-0.20.20.2-0.2-0.20.20.2-0.00.1-0.00.0
Total locomotion distance, hab. session 10.10.20.4-0.60.6-0.60.60.60.6-0.60.5-0.40.30.3-0.40.30.3-0.3-0.30.30.3-0.00.10.2-0.2
Locomotion velocity, hab. session 10.10.10.3-0.60.6-0.60.60.60.6-0.60.4-0.30.30.3-0.30.30.3-0.3-0.20.20.20.00.10.1-0.1
Time in familiar zone, hab. session 21.81.82.2-1.41.4-1.41.41.41.5-1.51.4-1.31.31.3-1.31.31.3-1.3-1.31.31.31.21.3-1.31.3
Time in novel zone, hab. session 22.22.22.51.5-1.51.5-1.5-1.5-1.61.6-1.51.5-1.5-1.51.4-1.4-1.51.51.4-1.4-1.5-1.3-1.41.4-1.4
Total zone transitions, hab. session 20.20.20.3-0.50.5-0.50.50.50.6-0.60.5-0.40.50.5-0.40.40.4-0.4-0.40.40.40.20.4-0.40.4
Total locomotion distance, hab. session 20.00.00.2-0.20.2-0.20.20.20.2-0.20.1-0.0-0.0-0.00.0-0.1-0.10.10.1-0.1-0.1-0.3-0.20.5-0.5
Locomotion velocity, hab. session 20.10.10.3-0.50.5-0.50.50.50.5-0.50.4-0.30.30.3-0.30.30.3-0.3-0.30.30.30.10.10.1-0.1
Novel to familiar place preference ratio2.32.42.61.6-1.61.6-1.6-1.6-1.61.6-1.51.5-1.5-1.51.4-1.5-1.51.51.5-1.5-1.5-1.4-1.51.6-1.6
Novelty place preference1.71.72.01.4-1.41.4-1.4-1.4-1.41.4-1.31.3-1.3-1.31.2-1.3-1.31.31.3-1.3-1.3-1.2-1.31.3-1.3
Time in novel zone, NPP test1.81.92.11.4-1.41.4-1.4-1.4-1.41.4-1.41.4-1.4-1.41.3-1.4-1.41.41.4-1.4-1.4-1.2-1.31.3-1.3
Total zone transitions, NPP test1.62.32.7-1.61.6-1.61.61.61.6-1.61.5-1.51.51.5-1.51.51.5-1.5-1.51.51.51.31.5-1.51.5
Total locomotion distance, NPP test0.20.30.5-0.70.7-0.70.70.70.7-0.70.5-0.40.40.4-0.40.40.4-0.4-0.40.40.40.20.3-0.20.2
Locomotion velocity, NPP test0.81.11.5-1.21.2-1.21.21.21.2-1.21.1-1.01.01.0-1.01.01.0-1.0-1.01.01.00.80.9-0.80.8
Intraocular pressure3.65.06.82.2-2.22.2-2.2-2.2-2.42.4-2.22.5-2.5-2.52.6-2.4-2.42.42.4-2.4-2.3-1.6-2.11.7-1.7
Delta distance traveled before/after self-admin0.50.50.8-0.90.9-0.90.90.90.8-0.80.8-0.70.70.7-0.80.70.7-0.7-0.70.70.70.20.6-0.70.7
Delta ambulatory time before/after self-admin0.50.60.8-0.80.8-0.80.80.80.9-0.90.8-0.70.70.7-0.80.70.7-0.7-0.70.70.70.30.6-0.60.6
Parametrial fat weight0.00.10.20.5-0.50.5-0.5-0.5-0.20.2-0.20.2-0.2-0.20.3-0.2-0.20.20.1-0.1-0.10.1-0.0-0.10.1
Pavlov. Cond. lever latency0.00.00.10.2-0.20.2-0.2-0.2-0.30.3-0.30.3-0.2-0.30.3-0.2-0.20.20.2-0.2-0.2-0.2-0.2-0.00.0
Pavlov. Cond. magazine entry latency2.22.83.5-1.71.7-1.71.71.71.8-1.81.8-1.81.81.8-1.91.71.8-1.7-1.71.71.71.11.5-1.21.2
Pavlov. Cond. change in total contacts3.33.53.9-1.91.9-1.91.91.91.9-1.91.9-2.01.91.9-2.01.91.9-1.9-1.91.91.91.71.8-1.61.6
Pavlov. Cond. index score0.50.71.0-0.80.8-0.80.80.80.9-0.90.9-0.90.90.9-1.00.90.9-0.9-0.90.90.80.50.7-0.50.5
Pavlov. Cond. latency score0.20.20.4-0.50.5-0.50.50.50.6-0.60.5-0.60.50.5-0.60.50.5-0.5-0.50.50.50.20.3-0.10.1
Pavlov. Cond. lever contacts0.50.50.8-0.70.7-0.70.70.70.8-0.80.8-0.80.80.8-0.90.80.8-0.8-0.80.80.70.60.6-0.40.4
Pavlov. Cond. magazine entry number2.43.03.71.8-1.81.8-1.8-1.8-1.91.9-1.81.9-1.8-1.81.9-1.8-1.81.81.8-1.7-1.7-1.1-1.51.1-1.1
Pavlov. Cond. intertrial magazine entries5.56.67.32.7-2.72.7-2.7-2.7-2.72.7-2.62.7-2.6-2.62.7-2.6-2.62.62.6-2.6-2.6-2.1-2.42.2-2.2
Pavlov. Cond. lever-magazine prob. diff.0.80.91.2-1.01.0-1.01.01.01.0-1.01.0-1.11.01.0-1.11.01.0-1.0-1.01.01.00.60.9-0.60.6
Pavlov. Cond. response bias2.32.93.4-1.81.8-1.81.81.81.8-1.81.8-1.81.81.8-1.81.71.7-1.7-1.71.71.71.31.5-1.21.2
Pavlov. Cond. lever latency1.82.52.71.6-1.61.6-1.6-1.6-1.61.6-1.71.6-1.6-1.61.6-1.6-1.61.61.6-1.6-1.6-1.5-1.51.3-1.3
Pavlov. Cond. magazine entry latency1.01.11.3-1.11.1-1.11.11.11.1-1.11.1-1.11.11.1-1.11.11.1-1.1-1.11.11.10.90.9-0.60.6
Pavlov. Cond. change in total contacts5.06.97.3-2.72.7-2.72.72.72.6-2.62.7-2.72.72.7-2.72.72.7-2.7-2.72.72.72.42.6-2.32.3
Pavlov. Cond. index score2.53.23.6-1.81.8-1.81.81.81.8-1.81.9-1.91.91.9-1.91.81.8-1.8-1.81.81.81.61.7-1.41.4
Pavlov. Cond. latency score2.63.23.6-1.81.8-1.81.81.81.8-1.81.9-1.91.91.9-1.91.81.8-1.8-1.81.81.81.61.7-1.41.4
Pavlov. Cond. lever contacts1.92.62.9-1.71.7-1.71.71.71.7-1.71.7-1.71.61.6-1.61.61.6-1.6-1.61.61.61.61.6-1.41.4
Pavlov. Cond. magazine entry number1.82.22.71.6-1.61.6-1.6-1.6-1.61.6-1.61.6-1.6-1.61.6-1.5-1.61.51.5-1.5-1.5-1.1-1.31.0-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.60.6-0.60.60.60.3-0.30.2-0.10.10.1-0.10.20.2-0.2-0.20.20.20.30.3-0.60.6
Pavlov. Cond. lever-magazine prob. diff.2.63.43.8-1.91.9-1.91.91.91.9-1.92.0-1.91.91.9-1.91.91.9-1.9-1.91.91.91.71.7-1.41.4
Pavlov. Cond. response bias1.62.22.6-1.61.6-1.61.61.61.5-1.51.6-1.51.51.5-1.51.51.5-1.5-1.51.51.51.31.4-1.21.2
Time in closed arm before self-admin0.00.00.1-0.20.2-0.20.20.20.3-0.30.2-0.20.20.2-0.30.20.2-0.2-0.20.20.2-0.10.1-0.20.2
Time in closed arm after self-admin0.50.50.90.7-0.70.7-0.7-0.7-0.30.3-0.50.6-0.7-0.60.6-0.7-0.70.70.7-0.7-0.7-0.9-0.80.9-0.9
Time in open arm before self-admin0.10.10.2-0.10.1-0.10.10.10.1-0.10.2-0.30.30.3-0.30.30.3-0.3-0.30.30.30.50.3-0.20.2
Time in open arm after self-admin0.30.30.50.3-0.30.3-0.3-0.3-0.70.7-0.70.6-0.6-0.60.6-0.6-0.60.60.6-0.6-0.6-0.3-0.50.4-0.4
Bone: periosteal estimation0.10.30.4-0.50.5-0.50.50.50.5-0.50.6-0.60.60.6-0.50.60.6-0.6-0.60.60.60.60.5-0.50.5
Bone: periosteal perimeter0.00.00.1-0.20.2-0.20.20.20.2-0.20.2-0.20.20.2-0.20.20.2-0.2-0.20.20.20.30.1-0.00.0
Bone: post-yield work0.00.00.0-0.10.1-0.10.10.1-0.00.0-0.00.1-0.0-0.00.1-0.0-0.00.00.0-0.0-0.0-0.10.0-0.10.1
Progressive ratio test 1 active lever presses1.41.42.5-1.61.6-1.61.61.61.2-1.21.0-1.01.01.0-1.01.01.0-1.0-1.01.01.01.41.1-1.11.1
Progressive ratio test 1 breakpoint1.61.72.9-1.71.7-1.71.71.71.3-1.31.1-1.11.11.1-1.11.11.1-1.1-1.11.11.11.51.1-1.11.1
Progressive ratio test 1 inactive lever presses0.50.51.4-0.60.6-0.60.60.60.7-0.70.6-0.70.70.7-0.70.70.7-0.7-0.70.70.71.20.8-0.80.8
Progressive ratio test 2 active lever presses0.30.30.9-0.50.5-0.50.50.50.7-0.70.5-0.50.50.5-0.40.50.5-0.5-0.50.50.51.00.6-0.60.6
Progressive ratio test 2 breakpoint0.20.20.8-0.40.4-0.40.40.40.6-0.60.4-0.40.40.4-0.30.40.4-0.4-0.40.40.40.90.5-0.60.6
Progressive ratio test 2 inactive lever presses0.20.21.0-0.40.4-0.40.40.40.5-0.50.3-0.30.30.3-0.30.30.3-0.3-0.40.40.41.00.5-0.70.7
Incentive Sensitization - Responses0.40.41.0-0.10.1-0.10.10.10.8-0.80.7-0.70.70.7-0.60.70.7-0.7-0.70.70.71.00.8-0.80.8
Incentive Sensitization - Breakpoint0.30.30.70.1-0.10.1-0.1-0.10.6-0.60.5-0.50.50.5-0.40.50.5-0.5-0.50.50.60.90.6-0.60.6
Sum of active levers in priming session hrs 5-60.80.71.20.4-0.40.4-0.4-0.4-0.80.8-0.91.0-1.0-1.01.1-1.0-1.01.01.0-1.0-1.0-0.7-1.00.9-0.9
Progressive ratio0.00.00.2-0.40.4-0.40.40.4-0.10.1-0.10.1-0.1-0.10.1-0.1-0.10.10.1-0.1-0.10.1-0.10.2-0.2
Food seeking constrained by brief footshock2.43.03.9-2.02.0-2.02.02.01.6-1.61.5-1.71.71.7-1.81.71.7-1.7-1.71.71.71.61.6-1.51.5
Seeking ratio, punishment vs. effort0.60.71.0-0.60.6-0.60.60.60.8-0.80.8-0.90.90.9-0.90.90.9-0.9-0.90.90.90.80.9-1.01.0
Retroperitoneal fat weight0.72.32.81.7-1.71.7-1.7-1.7-1.51.5-1.41.6-1.5-1.61.6-1.5-1.51.51.5-1.5-1.5-1.3-1.31.0-1.0
Reaction time number correct9.513.715.6-4.04.0-4.04.04.03.8-3.83.6-3.63.63.6-3.63.63.6-3.6-3.63.63.63.63.6-3.63.6
Reaction time mean minus median0.10.10.2-0.00.0-0.00.00.00.4-0.40.4-0.30.30.3-0.20.30.3-0.3-0.30.30.30.40.2-0.10.1
Reaction time mean minus median AUC0.30.40.6-0.30.3-0.30.30.30.8-0.80.8-0.70.70.7-0.60.70.7-0.7-0.70.70.70.80.7-0.60.6
Reaction time num false alarms0.60.91.21.0-1.01.0-1.0-1.0-1.11.1-1.00.9-0.9-0.90.8-0.9-0.90.90.9-0.9-0.9-0.7-0.90.8-0.8
Reaction time num false alarms AUC1.11.52.01.1-1.11.1-1.1-1.1-1.41.4-1.31.3-1.3-1.31.2-1.2-1.31.31.2-1.2-1.2-1.0-1.21.0-1.0
Reaction time trials correct on left9.513.715.6-4.04.0-4.04.04.03.8-3.83.6-3.63.63.6-3.63.63.6-3.6-3.63.63.63.63.6-3.63.6
Reaction time trials on left9.713.915.8-4.04.0-4.04.04.03.8-3.83.7-3.63.63.6-3.63.63.6-3.6-3.63.63.63.63.6-3.63.6
Reaction time mean1.52.12.71.6-1.61.6-1.6-1.6-1.41.4-1.21.4-1.4-1.41.5-1.4-1.41.41.4-1.4-1.4-1.4-1.41.5-1.5
Reaction time mean AUC1.31.82.31.5-1.51.5-1.5-1.5-1.21.2-1.01.3-1.3-1.31.4-1.3-1.31.31.3-1.3-1.3-1.3-1.31.4-1.4
Median of all reaction times2.73.64.22.1-2.12.1-2.1-2.1-1.91.9-1.71.9-1.9-1.91.9-1.9-1.91.91.9-1.9-1.9-1.9-1.91.9-1.9
Reaction time omissions0.10.10.5-0.10.1-0.10.10.10.3-0.30.4-0.30.30.3-0.20.40.4-0.4-0.40.40.40.40.5-0.70.7
Reaction time false alarm rate6.38.810.03.0-3.03.0-3.0-3.0-3.23.2-3.02.9-3.0-2.92.9-2.9-2.92.92.9-2.9-2.9-2.7-2.92.7-2.7
Reaction time premature initiation rate3.85.05.4-2.22.2-2.22.22.22.3-2.32.3-2.32.32.3-2.32.32.3-2.3-2.32.32.32.12.2-2.02.0
Reaction time premature initiations11.516.217.2-4.24.2-4.24.24.24.1-4.14.0-4.14.04.0-4.04.04.0-4.0-4.04.04.03.83.9-3.73.7
Std. dev. reaction times0.10.10.30.6-0.60.6-0.6-0.6-0.20.2-0.10.3-0.3-0.30.4-0.3-0.30.30.3-0.3-0.3-0.2-0.30.3-0.3
Reaction time trials completed9.713.915.8-4.04.0-4.04.04.03.8-3.83.7-3.63.63.6-3.63.63.6-3.6-3.63.63.63.63.6-3.63.6
Reaction time trials AUC8.712.614.2-3.83.8-3.83.83.83.6-3.63.5-3.43.53.4-3.43.53.5-3.5-3.53.53.53.53.5-3.53.5
Run reversals in cocaine runway, females0.60.51.20.5-0.50.5-0.5-0.5-0.70.7-0.80.8-0.8-0.80.8-0.8-0.80.80.8-0.8-0.8-1.1-0.80.8-0.8
Run reversals in cocaine runway, males0.10.10.3-0.10.1-0.10.10.10.4-0.40.3-0.20.10.2-0.30.10.1-0.1-0.10.10.0-0.1-0.20.5-0.5
Latency to leave start box in cocaine runway2.12.33.01.1-1.11.1-1.1-1.1-1.51.5-1.51.6-1.6-1.61.6-1.6-1.61.61.6-1.6-1.6-1.7-1.61.6-1.6
Latency to leave start box in cocaine runway, F0.30.30.50.3-0.30.3-0.3-0.3-0.60.6-0.50.6-0.6-0.60.7-0.6-0.60.60.6-0.6-0.6-0.7-0.60.5-0.5
Latency to leave start box in cocaine runway, M2.32.23.61.2-1.21.2-1.2-1.2-1.41.4-1.51.5-1.5-1.51.5-1.6-1.61.61.6-1.6-1.6-1.9-1.61.7-1.7
Std. dev. time between licks in bursts0.91.11.51.0-1.01.0-1.0-1.0-0.90.9-1.01.0-1.1-1.01.0-1.1-1.11.11.1-1.1-1.1-1.2-1.11.2-1.2
Total sessions with >9 infusions1.31.42.6-1.61.6-1.61.61.61.4-1.41.1-1.00.90.9-0.91.00.9-0.9-0.90.90.91.30.9-0.90.9
Short access day 1 total inactive lever presses0.00.00.3-0.20.2-0.20.20.2-0.00.0-0.10.00.0-0.00.10.00.0-0.0-0.10.10.10.50.2-0.40.4
Short access day 10 total inactive lever presses0.50.60.80.7-0.70.7-0.7-0.7-0.70.7-0.80.7-0.8-0.80.8-0.8-0.80.80.8-0.8-0.8-0.9-0.80.9-0.9
Short access day 1 total infusions1.31.32.9-1.11.1-1.11.11.11.1-1.11.1-1.11.11.1-1.01.11.1-1.1-1.11.11.11.71.2-1.21.2
Short access day 10 total infusions1.51.72.4-1.41.4-1.41.41.41.5-1.51.3-1.21.21.2-1.21.21.2-1.2-1.21.21.21.61.3-1.21.2
Short access total infusions2.02.23.4-1.61.6-1.61.61.61.5-1.51.4-1.41.41.4-1.41.41.4-1.4-1.41.41.41.81.5-1.51.5
Short access day 1 locomotion0.40.40.9-0.70.7-0.70.70.70.8-0.80.6-0.50.60.5-0.50.60.6-0.6-0.60.60.60.90.7-0.80.8
Short access day 10 total locomotion0.00.00.10.1-0.10.1-0.1-0.10.3-0.30.00.1-0.0-0.10.2-0.0-0.00.00.0-0.0-0.00.40.1-0.30.3
Short access total locomotion2.12.13.1-1.51.5-1.51.51.51.6-1.61.4-1.31.31.3-1.21.31.3-1.3-1.31.31.31.81.5-1.71.7
One hour access (0.3 mA shock)1.31.52.3-1.51.5-1.51.51.51.3-1.31.0-1.01.01.0-1.01.01.0-1.0-1.11.11.11.51.2-1.41.4
Compulsive drug intake0.20.20.5-0.20.2-0.20.20.2-0.30.3-0.50.5-0.4-0.50.5-0.5-0.40.40.4-0.4-0.4-0.7-0.40.3-0.3
One hour access (shock baseline)2.42.84.5-1.81.8-1.81.81.81.7-1.71.6-1.51.51.5-1.51.61.5-1.5-1.61.61.62.11.6-1.71.7
Social response proportion0.10.10.2-0.40.4-0.40.40.4-0.30.3-0.20.3-0.3-0.30.2-0.3-0.30.30.3-0.3-0.3-0.5-0.30.3-0.3
Social responses1.72.23.9-2.02.0-2.02.02.01.6-1.61.4-1.41.41.4-1.61.31.4-1.3-1.31.31.30.71.1-0.90.9
Social time0.00.00.0-0.20.2-0.20.20.2-0.10.1-0.00.1-0.1-0.10.1-0.1-0.10.10.1-0.1-0.10.1-0.0-0.10.1
Soleus weight0.20.61.01.0-1.01.0-1.0-1.0-0.90.9-0.80.8-0.8-0.80.9-0.7-0.80.70.7-0.7-0.7-0.2-0.60.3-0.3
Bone: stiffness0.30.50.7-0.80.8-0.80.80.80.8-0.80.8-0.80.70.8-0.70.70.7-0.7-0.70.70.70.80.6-0.40.4
Tibialis anterior weight2.37.910.12.6-2.62.6-2.6-2.6-2.92.9-2.92.9-2.9-2.92.8-2.9-2.92.92.9-2.9-2.9-3.2-2.82.6-2.6
Time to tail flick, vehicle, before self-admin4.64.75.4-2.32.3-2.32.32.32.2-2.22.2-2.12.12.1-2.02.12.1-2.1-2.12.12.12.32.2-2.22.2
Time to tail flick, vehicle, after self-admin1.51.62.3-0.90.9-0.90.90.91.2-1.21.4-1.51.51.5-1.51.41.4-1.4-1.41.41.41.41.3-1.01.0
Time to tail flick, test, before self-admin0.10.10.3-0.20.2-0.20.20.20.3-0.30.3-0.30.30.3-0.20.30.3-0.3-0.30.30.30.60.4-0.50.5
Time to tail flick, test, after self-admin0.50.61.00.5-0.50.5-0.5-0.5-0.80.8-0.90.9-0.9-0.90.9-0.9-0.80.80.8-0.8-0.8-1.0-0.70.3-0.3
Delta time to tail flick, vehicle, before/after SA1.51.52.81.7-1.71.7-1.7-1.7-1.21.2-1.10.9-0.9-0.90.9-1.0-1.01.01.0-1.0-1.0-1.1-1.11.2-1.2
Delta time to tail flick, test, before/after SA0.10.10.50.1-0.10.1-0.1-0.1-0.30.3-0.30.3-0.3-0.30.2-0.3-0.30.30.3-0.3-0.3-0.7-0.30.2-0.2
Tibia length6.217.521.6-4.14.1-4.14.14.14.1-4.14.2-4.14.14.1-3.94.24.1-4.2-4.24.24.24.74.4-4.44.4
Ambulatory time before self-admin0.70.70.9-0.80.8-0.80.80.80.6-0.60.9-0.90.90.9-0.90.90.9-0.9-0.90.90.90.90.9-0.70.7
Ambulatory time after self-admin0.80.91.4-0.70.7-0.70.70.71.0-1.01.1-1.01.01.0-1.21.01.0-1.0-1.01.01.00.60.9-0.80.8
Bone: tissue strength1.11.11.31.1-1.11.1-1.1-1.1-1.01.0-1.01.0-1.0-1.01.1-1.0-1.01.01.0-1.0-1.0-0.7-1.01.0-1.0
Total heroin consumption1.11.31.90.3-0.30.3-0.3-0.3-1.31.3-1.21.3-1.3-1.31.4-1.3-1.31.31.3-1.3-1.3-1.3-1.21.2-1.2
Bone: trabecular number0.00.00.10.2-0.20.2-0.2-0.2-0.10.1-0.10.1-0.1-0.10.1-0.1-0.10.10.1-0.1-0.1-0.3-0.20.3-0.3
Bone: trabecular spacing0.10.10.20.3-0.30.3-0.3-0.3-0.40.4-0.40.4-0.3-0.30.4-0.3-0.30.30.3-0.3-0.3-0.3-0.1-0.40.4
Bone: trabecular thickness1.11.32.01.2-1.21.2-1.2-1.2-1.11.1-1.01.0-1.1-1.11.1-1.1-1.11.11.1-1.1-1.1-0.9-1.21.4-1.4
Bone: trabecular tissue density2.43.43.71.8-1.81.8-1.8-1.8-1.81.8-1.81.8-1.8-1.81.8-1.8-1.81.81.8-1.8-1.8-1.9-1.81.7-1.7
Water consumed over 24 hours0.60.70.80.8-0.80.8-0.8-0.8-0.90.9-0.90.9-0.9-0.90.9-0.9-0.90.90.9-0.9-0.9-0.8-0.80.8-0.8
Number of responses in last shaping day0.30.30.5-0.20.2-0.20.20.2-0.70.7-0.60.7-0.7-0.70.7-0.6-0.70.60.6-0.6-0.6-0.1-0.60.5-0.5