Hub : Genes

Trim23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Trim23 0.04 0.04 3.2e-05 0.03 0.04 0.03 0.03 1.4e-04 4.3e-05 1.0e-04 1.2e-04
2 Adipose gene expression Trim23 0.06 0.06 2.0e-05 0.03 0.03 0.03 0.03 6.3e-04 1.0e-04 4.5e-04 5.2e-04
3 pVTA mRNA stability Trim23 0.07 0.06 3.8e-06 0.07 0.02 0.06 0 4.0e-06 6.6e-03 1.6e-05 2.5e-01
4 pVTA gene expression Trim23 0.08 0.07 1.9e-05 0.06 0 0.05 0.01 2.9e-05 2.3e-01 9.5e-05 1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.71.31.7-1.0-1.01.1-1.3
Area under the delay curve0.30.30.70.70.40.10.9
BMI with tail2.37.88.6-2.7-2.82.9-2.8
BMI without tail0.41.41.6-1.1-1.11.3-1.2
Body weight3.515.416.94.14.0-3.73.9
Weight adjusted by age0.10.10.20.20.3-0.40.3
Bone surface0.00.00.00.0-0.00.2-0.2
Bone volume0.10.10.2-0.2-0.30.4-0.5
Breakpoint value in progressive ratio session3.13.84.1-1.9-1.92.0-1.9
Number of licking bursts2.03.33.6-1.9-1.91.9-1.7
Context. condit. distance diff. score1.41.72.11.51.3-1.11.3
Locomotion velocity, session 10.20.20.30.60.5-0.50.3
Locomotion distance, session 10.60.80.91.00.9-0.90.8
Locomotion velocity, session 24.14.85.32.22.3-2.31.9
Locomotion distance, session 20.60.81.11.00.9-0.80.8
Locomotion velocity, session 35.15.86.02.42.4-2.52.4
Locomotion distance, session 37.38.08.22.82.8-2.92.8
Stereotopy head waving bouts, day 30.40.40.90.50.6-0.90.5
Stereotopy head waving duration, day 30.00.00.0-0.2-0.1-0.2-0.2
Locomotion velocity, session 70.10.10.10.20.3-0.30.3
Locomotion distance, session 70.30.40.60.70.6-0.50.8
Stereotopy head waving bouts, day 70.10.10.2-0.10.1-0.5-0.2
Stereotopy head waving duration, day 70.20.20.60.30.4-0.80.2
Locomotion velocity, session 82.12.52.91.71.7-1.41.5
Locomotion distance, session 83.75.46.52.52.4-2.12.3
Degree of sensitization distance3.53.63.8-2.0-1.81.9-1.9
Degree of sensitization stereotypy0.00.00.1-0.2-0.1-0.2-0.3
Conditioned locomotion0.00.00.0-0.0-0.0-0.10.1
Cocaine response after cond. corrected1.82.22.71.41.4-1.41.7
Cocaine response after cond. not corrected2.42.83.31.71.6-1.61.8
Cocaine response before conditioning0.20.20.30.60.5-0.30.3
Saline control response1.11.51.61.31.3-1.21.1
Bone: connectivity density0.10.10.2-0.3-0.30.3-0.4
Bone: cortical apparent density0.00.00.10.10.1-0.20.3
Bone: cortical area0.20.30.40.50.6-0.60.3
Bone: cortical porosity2.02.23.0-1.6-1.41.1-1.7
Bone: cortical porosity1.82.02.7-1.6-1.40.9-1.6
Bone: cortical thickness0.20.30.60.30.5-0.80.3
Bone: cortical thickness1.01.21.51.21.1-1.01.0
Bone: cortical tissue density0.00.10.10.10.2-0.30.3
Condit. Reinf. active minus inactive responses1.11.21.9-1.4-1.10.7-1.1
Condit. Reinf. active-inactive response ratio1.21.31.9-1.4-1.20.8-1.1
Condit. Reinf. active responses0.10.10.3-0.5-0.4-0.0-0.3
Condit. Reinf. inactive responses1.11.31.41.21.1-1.11.2
Incentive salience index mean0.81.01.4-1.2-1.00.7-1.0
Condit. Reinf. lever presses0.20.20.3-0.5-0.50.4-0.5
Condit. Reinf. active minus inactive responses4.25.45.72.42.4-2.22.3
Condit. Reinf. active-inactive response ratio2.52.92.91.61.7-1.71.7
Condit. Reinf. active responses1.41.92.11.41.4-1.31.4
Condit. Reinf. inactive responses0.00.00.10.30.2-0.10.1
Condit. Reinf. lever presses2.02.73.21.61.6-1.61.8
Condit. Reinf. lever reinforcers received1.92.72.81.71.7-1.61.6
Conditioned reinforcement - actives1.93.23.31.81.8-1.81.8
Conditioned reinforcement - inactives1.01.51.91.11.2-1.21.4
Conditioned locomotion0.81.11.51.01.0-1.20.9
Patch foraging indifference point 0 sec4.07.38.12.62.7-2.72.8
Patch foraging indifference point AUC0.60.81.1-0.7-0.81.0-1.0
Delay disc. indifference point, 0s delay0.30.40.4-0.6-0.60.6-0.6
Delay disc. indifference point, 16s delay0.91.01.61.10.9-0.41.3
Delay disc. indifference point, 2s delay0.10.10.2-0.4-0.30.2-0.4
Delay disc. indifference point, 24s delay0.70.81.51.00.7-0.11.2
Delay disc. indifference point, 4s delay0.00.00.00.10.0-0.00.1
Delay disc. indifference point, 8s delay0.20.20.50.40.10.40.7
Indifference point function ln k3.25.76.22.32.4-2.42.5
Indifference point function log k3.25.76.22.32.4-2.42.5
Patch foraging total patch changes 0 sec4.78.99.52.83.0-3.03.1
Patch foraging total patch changes 12 sec0.00.00.00.10.0-0.1-0.2
Patch foraging total patch changes 18 sec0.00.00.00.00.1-0.20.1
Patch foraging total patch changes 24 sec0.71.21.51.01.1-1.21.0
Patch foraging total patch changes 6 sec1.01.51.51.21.2-1.21.2
Patch foraging time to switch 0 sec4.69.410.4-3.0-3.13.2-2.9
Patch foraging water rate 0 sec3.77.88.72.82.9-2.92.6
Patch foraging water rate 12 sec3.87.98.42.72.8-2.92.8
Patch foraging water rate 18 sec5.68.78.93.03.0-3.02.9
Patch foraging water rate 24 sec2.83.94.82.02.1-2.21.7
Patch foraging water rate 6 sec13.119.219.94.44.5-4.44.2
Seeking ratio, delayed vs. immediate footshock1.11.31.3-1.2-1.11.1-1.2
Distance traveled before self-admin0.70.91.11.01.0-1.00.8
Distance traveled after self-admin1.51.82.11.31.4-1.41.3
Extensor digitorum longus weight3.714.717.5-3.9-3.83.5-4.2
Bone: elastic displacement1.61.92.1-1.5-1.41.3-1.3
Bone: elastic work0.40.50.6-0.8-0.80.5-0.7
Bone: endosteal estimation0.30.60.90.90.8-0.60.8
Bone: endosteal perimeter0.00.00.00.20.10.00.2
Epididymis fat weight1.03.33.71.81.9-1.91.7
Delta time in closed arm before/after self-admin4.44.16.4-1.8-2.02.5-1.6
Delta time in open arm before/after self-admin0.10.10.2-0.4-0.30.2-0.4
Diff in mean of infusions in LGA sessions0.00.00.00.00.1-0.2-0.0
Delay discount exponential model param0.30.30.8-0.7-0.4-0.1-0.9
Extinction: sum of active levers before priming2.52.72.9-1.7-1.71.7-1.5
Active lever presses in extinction session 63.13.13.1-1.8-1.81.7-1.7
Bone: final force0.40.60.70.80.8-0.80.7
Bone: final moment0.61.01.11.01.0-1.01.0
Food consumed during 24 hour testing period1.01.31.61.11.2-1.31.0
Glucose0.20.20.4-0.7-0.40.4-0.4
Heart weight0.71.01.11.01.0-1.01.0
Delay discount hyperbolic model param0.30.30.6-0.6-0.40.1-0.8
Intermittent access intake day 1-15 change0.00.10.2-0.10.1-0.50.0
Intermittent access intake escalation0.10.20.50.30.4-0.70.4
Intermittent access intake escalation 20.10.10.2-0.5-0.40.1-0.4
Intermitt. access day 1 inactive lever presses0.41.31.5-1.2-1.21.2-1.1
Intermitt. access day 15 inactive lever presses0.51.11.2-1.0-1.11.1-1.0
Intermitt. access escalation Index0.20.30.40.60.5-0.50.5
Intermittent access day 1 total infusions1.11.71.91.41.3-1.21.3
Intermittent access day 15 total infusions2.33.43.81.71.9-2.01.8
Intermittent access terminal intake (last 3 days)1.31.71.81.31.3-1.41.3
Intermittent access total infusions3.44.04.22.02.0-2.02.0
Intermittent access day 1 locomotion2.53.13.71.71.8-1.91.6
Intermittent access day 15 total locomotion2.34.25.41.92.0-2.31.9
Intermittent access total locomotion5.16.27.12.42.5-2.72.3
Intermittent access standard deviation0.00.00.1-0.2-0.20.0-0.3
Left kidney weight2.712.613.23.53.6-3.63.4
Right kidney weight2.511.612.03.43.5-3.43.4
Cocaine induced anxiety0.71.01.21.10.9-0.81.1
Post-drug Anxiety0.60.60.90.80.7-0.61.0
Baseline Anxiety0.00.10.1-0.3-0.20.1-0.2
Tail length10.239.841.26.36.4-6.46.1
Length with tail15.165.667.78.28.2-8.08.0
Length without tail10.533.835.56.05.8-5.75.8
Times rat made contact with spout0.40.40.6-0.6-0.60.8-0.6
Lifetime Intake2.73.33.41.81.8-1.81.8
Liver weight, left6.010.012.12.93.2-3.53.0
Liver weight, right0.20.30.60.20.5-0.80.6
Locomotor activity0.20.40.50.70.5-0.40.7
Locomotor testing distance0.20.30.5-0.6-0.60.7-0.4
Locomotor testing rearing0.10.20.2-0.5-0.50.4-0.3
Locomotion in novel chamber0.70.91.1-0.9-1.01.1-0.9
Locomotion in novel chamber post-restriction0.00.10.1-0.1-0.30.4-0.1
Fecal boli incidents, locomotor time 11.52.23.2-1.4-1.41.8-1.3
Change in fecal boli incidents, locomotor task0.10.10.2-0.1-0.1-0.3-0.4
Time >=10cm from walls, locomotor time 12.12.22.6-1.6-1.51.3-1.6
Bouts of movement, locomotor time 10.40.50.9-0.7-0.70.9-0.3
Total resting periods, locomotor time 10.10.20.4-0.2-0.30.70.1
Rest time, locomotor task time 10.91.21.8-1.0-1.11.4-0.9
Distance moved, locomotor task time 11.21.83.11.21.3-1.70.9
Vertical activity count, locomotor time 10.40.91.71.01.0-1.30.5
Time >=10cm from walls, locomotor time 20.91.41.6-1.1-1.21.3-1.2
Bouts of movement, locomotor time 20.10.10.20.40.20.30.4
Total resting periods, locomotor time 20.10.10.5-0.1-0.20.7-0.0
Rest time, locomotor task time 23.24.14.7-2.1-2.02.2-1.8
Distance moved, locomotor task time 21.41.72.11.41.3-1.51.0
Vertical activity count, locomotor time 20.20.30.70.50.5-0.9-0.2
Light reinforcement 11.84.54.82.02.2-2.22.2
Light reinforcement 20.00.10.2-0.4-0.30.2-0.1
Bone: marrow area0.30.60.90.90.8-0.60.8
Bone: maximum diameter0.30.50.7-0.6-0.60.7-0.8
Bone: maximum force0.10.20.20.50.4-0.50.4
Bone: maximum moment0.30.50.60.80.7-0.70.7
Mean time between licks in bursts0.00.10.1-0.4-0.40.3-0.3
Mean num. licks in bursts1.42.22.31.51.5-1.51.3
Cd content in liver2.42.73.21.41.6-1.81.7
Co content in liver0.00.00.0-0.1-0.10.0-0.2
Cu content in liver0.10.10.30.20.3-0.50.4
Fe content in liver1.21.41.51.21.2-1.21.1
K content in liver0.80.71.31.10.9-0.60.7
Mg content in liver0.10.10.30.1-0.20.6-0.2
Mn content in liver0.50.60.80.70.8-0.90.7
Na content in liver0.10.10.2-0.2-0.20.4-0.2
Rb content in liver1.72.02.31.31.4-1.41.5
Se content in liver0.81.01.3-0.9-0.91.0-1.1
Sr content in liver2.52.22.4-1.4-1.51.5-1.5
Zn content in liver0.10.10.20.40.3-0.30.4
Bone: minimum diameter2.64.74.82.22.2-2.22.1
Time in familiar zone, hab. session 14.44.34.32.12.1-2.02.1
Time in novel zone, hab. session 16.26.26.3-2.5-2.52.5-2.5
Total zone transitions, hab. session 10.00.00.10.1-0.00.1-0.2
Total locomotion distance, hab. session 10.00.00.10.30.10.20.1
Locomotion velocity, hab. session 10.00.00.10.30.10.10.0
Time in familiar zone, hab. session 21.81.92.01.41.3-1.41.4
Time in novel zone, hab. session 22.22.32.4-1.6-1.51.5-1.5
Total zone transitions, hab. session 20.00.00.10.30.2-0.0-0.1
Total locomotion distance, hab. session 20.10.10.2-0.1-0.30.4-0.4
Locomotion velocity, hab. session 20.00.00.10.30.10.1-0.0
Novel to familiar place preference ratio1.92.12.4-1.6-1.51.4-1.3
Novelty place preference1.41.51.8-1.3-1.31.2-1.1
Time in novel zone, NPP test1.61.72.0-1.4-1.31.3-1.2
Total zone transitions, NPP test1.11.62.01.41.3-1.11.2
Total locomotion distance, NPP test0.10.10.20.40.3-0.10.3
Locomotion velocity, NPP test0.50.71.01.00.9-0.70.8
Intraocular pressure3.24.75.7-2.4-2.11.8-2.3
Delta distance traveled before/after self-admin1.01.11.21.01.0-1.11.1
Delta ambulatory time before/after self-admin0.81.01.21.01.0-0.91.1
Parametrial fat weight0.00.10.10.20.20.00.3
Pavlov. Cond. lever latency0.00.00.0-0.1-0.00.0-0.1
Pavlov. Cond. magazine entry latency1.41.82.41.51.3-1.11.3
Pavlov. Cond. change in total contacts3.33.53.81.91.9-1.91.8
Pavlov. Cond. index score0.50.60.80.90.8-0.70.8
Pavlov. Cond. latency score0.20.20.30.50.4-0.30.5
Pavlov. Cond. lever contacts0.50.60.80.90.8-0.70.8
Pavlov. Cond. magazine entry number2.43.03.9-2.0-1.71.5-1.7
Pavlov. Cond. intertrial magazine entries5.06.06.9-2.6-2.52.4-2.3
Pavlov. Cond. lever-magazine prob. diff.0.70.81.11.10.9-0.80.9
Pavlov. Cond. response bias2.12.53.31.81.6-1.41.5
Pavlov. Cond. lever latency2.73.64.6-1.9-1.91.6-2.2
Pavlov. Cond. magazine entry latency0.81.01.31.21.0-0.71.1
Pavlov. Cond. change in total contacts4.57.28.12.72.7-2.52.8
Pavlov. Cond. index score2.43.23.91.91.8-1.52.0
Pavlov. Cond. latency score2.43.24.01.91.8-1.42.0
Pavlov. Cond. lever contacts2.12.83.71.71.7-1.41.9
Pavlov. Cond. magazine entry number1.62.02.7-1.6-1.40.9-1.5
Pavlov. Cond. intertrial magazine entries0.00.00.10.10.3-0.30.0
Pavlov. Cond. lever-magazine prob. diff.2.53.34.11.91.8-1.52.0
Pavlov. Cond. response bias1.52.02.61.51.4-1.21.6
Time in closed arm before self-admin0.30.40.60.60.6-0.70.5
Time in closed arm after self-admin0.10.10.2-0.2-0.40.5-0.4
Time in open arm before self-admin0.10.10.10.30.3-0.10.3
Time in open arm after self-admin0.40.50.7-0.8-0.70.5-0.6
Bone: periosteal estimation0.20.50.60.80.8-0.70.6
Bone: periosteal perimeter0.10.20.20.50.4-0.30.4
Bone: post-yield work0.20.20.30.50.5-0.50.4
Progressive ratio test 1 active lever presses2.22.72.91.61.7-1.71.6
Progressive ratio test 1 breakpoint2.53.03.21.71.8-1.81.7
Progressive ratio test 1 inactive lever presses0.91.31.41.11.2-1.21.1
Progressive ratio test 2 active lever presses2.42.83.01.71.6-1.51.7
Progressive ratio test 2 breakpoint2.52.93.31.81.7-1.61.8
Progressive ratio test 2 inactive lever presses0.71.11.21.01.1-1.11.0
Incentive Sensitization - Responses2.63.74.22.01.9-1.72.1
Incentive Sensitization - Breakpoint2.33.03.51.81.7-1.61.9
Sum of active levers in priming session hrs 5-61.91.72.0-1.4-1.31.1-1.4
Progressive ratio0.10.10.20.30.3-0.20.4
Food seeking constrained by brief footshock2.53.03.31.81.8-1.61.7
Seeking ratio, punishment vs. effort0.60.80.90.90.9-0.90.8
Retroperitoneal fat weight0.00.20.30.50.5-0.30.5
Reaction time number correct6.512.514.83.63.6-3.83.1
Reaction time mean minus median0.00.00.00.1-0.00.10.1
Reaction time mean minus median AUC0.10.20.20.50.4-0.40.4
Reaction time num false alarms0.30.40.6-0.7-0.70.8-0.5
Reaction time num false alarms AUC0.61.01.2-1.1-1.01.0-0.9
Reaction time trials correct on left6.512.514.83.63.6-3.83.1
Reaction time trials on left6.712.715.03.63.6-3.93.2
Reaction time mean1.62.62.7-1.7-1.71.6-1.5
Reaction time mean AUC1.42.32.5-1.5-1.61.6-1.4
Median of all reaction times2.83.94.3-2.1-2.02.0-1.8
Reaction time omissions0.30.40.60.50.7-0.80.6
Reaction time false alarm rate5.27.28.4-2.8-2.72.9-2.3
Reaction time premature initiation rate3.85.35.82.32.3-2.22.4
Reaction time premature initiations8.915.916.54.04.0-4.13.8
Std. dev. reaction times0.20.30.4-0.6-0.60.5-0.6
Reaction time trials completed6.712.715.03.63.6-3.93.2
Reaction time trials AUC6.111.714.03.43.4-3.73.0
Run reversals in cocaine runway, females0.40.40.6-0.7-0.70.8-0.4
Run reversals in cocaine runway, males0.10.10.40.1-0.10.7-0.1
Latency to leave start box in cocaine runway2.62.93.7-1.6-1.71.9-1.6
Latency to leave start box in cocaine runway, F0.20.30.4-0.5-0.50.6-0.3
Latency to leave start box in cocaine runway, M2.92.73.2-1.5-1.61.8-1.7
Std. dev. time between licks in bursts0.81.01.1-0.9-1.01.1-1.1
Total sessions with >9 infusions0.81.01.01.01.0-1.00.9
Short access day 1 total inactive lever presses1.31.72.01.21.3-1.31.4
Short access day 10 total inactive lever presses0.10.30.4-0.5-0.50.6-0.3
Short access day 1 total infusions0.40.60.60.70.8-0.70.8
Short access day 10 total infusions1.51.92.01.41.4-1.41.4
Short access total infusions1.21.51.61.21.3-1.21.3
Short access day 1 locomotion0.10.10.20.30.4-0.50.2
Short access day 10 total locomotion0.40.81.0-1.0-0.90.7-1.0
Short access total locomotion0.30.40.60.50.6-0.80.4
One hour access (0.3 mA shock)2.12.52.71.51.6-1.61.5
Compulsive drug intake1.82.12.4-1.4-1.51.6-1.3
One hour access (shock baseline)3.45.25.62.22.3-2.42.2
Social response proportion0.10.10.1-0.2-0.20.3-0.3
Social responses0.81.01.61.31.1-0.60.9
Social time0.00.00.0-0.10.0-0.1-0.1
Soleus weight0.10.40.6-0.8-0.60.3-0.7
Bone: stiffness0.20.30.40.60.5-0.40.5
Tibialis anterior weight2.79.310.1-3.0-3.03.0-3.2
Time to tail flick, vehicle, before self-admin2.12.22.61.31.5-1.61.4
Time to tail flick, vehicle, after self-admin0.00.00.00.20.10.1-0.0
Time to tail flick, test, before self-admin0.10.10.1-0.4-0.30.3-0.3
Time to tail flick, test, after self-admin1.41.52.6-1.2-1.10.8-1.6
Delta time to tail flick, vehicle, before/after SA1.21.21.7-0.9-1.01.3-1.1
Delta time to tail flick, test, before/after SA0.00.00.0-0.0-0.10.0-0.2
Tibia length7.119.621.54.34.5-4.64.3
Ambulatory time before self-admin0.10.20.30.40.5-0.50.3
Ambulatory time after self-admin1.01.21.31.11.1-1.11.1
Bone: tissue strength0.60.60.9-0.9-0.80.4-1.0
Total heroin consumption1.31.62.1-1.3-1.21.0-1.4
Bone: trabecular number0.00.00.10.0-0.00.2-0.3
Bone: trabecular spacing0.00.10.1-0.4-0.2-0.1-0.1
Bone: trabecular thickness0.70.91.0-0.9-0.90.9-1.0
Bone: trabecular tissue density2.63.83.9-2.0-2.02.0-1.9
Water consumed over 24 hours0.40.50.6-0.8-0.70.8-0.7
Number of responses in last shaping day0.60.70.9-0.9-0.80.6-1.0