Hub : Genes

Trim10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Trim10	0.08	0.05	4.3e-06	0.06	0.07	0.06	0.07	1.0e-05	2.3e-06	6.2e-06	5.0e-06
2	Brain	gene expression	Trim10	0.04	0.02	2.2e-03	0.04	0.03	0.03	0.03	2.9e-04	2.1e-03	1.1e-03	1.8e-03
3	NAcc	gene expression	Trim10	0.04	0.02	6.8e-04	-0	0.01	0.02	0.01	5.6e-01	5.0e-03	7.6e-04	3.7e-02
4	PL	gene expression	Trim10	0.05	0.03	6.2e-06	0.03	0.04	0.06	0.05	2.1e-04	1.1e-05	5.3e-07	4.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.2	4.0	9.1	-1.5	0.5	3.0	2.1
Area under the delay curve	0.4	0.6	1.8	0.3	-0.2	-0.6	-1.3
BMI with tail	0.3	1.2	2.1	-1.4	1.4	-0.7	-0.6
BMI without tail	0.5	2.6	7.9	-0.4	0.5	-2.8	-1.5
Body weight	2.6	11.5	16.8	2.7	-2.5	-4.0	-4.1
Weight adjusted by age	0.8	2.3	2.8	1.7	-1.2	-1.5	-1.6
Bone surface	0.7	1.4	3.1	1.1	-1.8	1.1	-0.0
Bone volume	0.4	0.9	2.9	0.1	-0.6	1.7	0.5
Breakpoint value in progressive ratio session	0.1	0.1	0.4	-0.6	0.1	0.1	0.3
Number of licking bursts	0.4	1.1	2.2	1.1	-0.6	-1.5	-0.9
Context. condit. distance diff. score	0.7	0.9	2.0	1.4	-0.6	0.7	0.9
Locomotion velocity, session 1	0.7	0.7	2.1	0.7	-1.4	0.6	-0.1
Locomotion distance, session 1	1.4	1.8	2.9	-1.4	0.8	1.7	1.3
Locomotion velocity, session 2	0.3	0.4	0.6	0.4	-0.7	-0.5	-0.8
Locomotion distance, session 2	0.7	1.1	2.4	-0.6	-0.1	1.6	1.2
Locomotion velocity, session 3	0.5	0.6	1.5	-1.0	1.2	-0.3	0.0
Locomotion distance, session 3	0.6	0.7	1.2	-0.7	1.0	0.2	1.1
Stereotopy head waving bouts, day 3	2.1	2.4	2.9	1.6	-1.5	-1.4	-1.7
Stereotopy head waving duration, day 3	1.0	1.2	1.8	1.2	-1.1	-0.7	-1.3
Locomotion velocity, session 7	1.3	1.5	3.2	-0.4	1.0	1.2	1.8
Locomotion distance, session 7	2.6	3.3	4.9	-1.1	2.0	1.8	2.2
Stereotopy head waving bouts, day 7	1.3	1.5	2.9	1.0	-1.0	-1.1	-1.7
Stereotopy head waving duration, day 7	1.6	1.9	3.3	1.0	-1.2	-1.4	-1.8
Locomotion velocity, session 8	3.8	4.6	8.1	2.8	-2.8	-0.5	-1.4
Locomotion distance, session 8	0.6	0.9	1.3	1.0	-0.6	1.0	1.1
Degree of sensitization distance	0.2	0.2	0.7	0.9	-0.1	0.4	-0.1
Degree of sensitization stereotypy	0.3	0.4	0.8	0.3	-0.4	-0.6	-0.9
Conditioned locomotion	1.6	1.9	4.0	0.7	-0.5	-2.0	-1.7
Cocaine response after cond. corrected	0.3	0.4	1.2	-0.7	0.1	1.1	0.2
Cocaine response after cond. not corrected	0.5	0.8	1.2	0.9	-1.1	-0.1	-1.0
Cocaine response before conditioning	4.8	5.8	6.6	2.6	-2.0	-2.6	-2.5
Saline control response	0.4	0.5	1.1	-0.8	0.5	-1.0	-0.4
Bone: connectivity density	2.0	3.2	7.6	-0.8	-0.3	2.8	2.1
Bone: cortical apparent density	0.6	1.0	1.8	-1.3	1.2	0.8	-0.0
Bone: cortical area	0.4	0.6	1.0	1.0	-1.0	-0.1	-0.7
Bone: cortical porosity	0.0	0.0	0.1	-0.0	0.1	-0.4	-0.2
Bone: cortical porosity	0.4	0.4	0.6	0.7	-0.5	-0.8	-0.5
Bone: cortical thickness	0.7	1.1	2.0	-1.4	1.1	1.1	-0.0
Bone: cortical thickness	2.0	2.5	5.0	-2.1	2.2	0.7	0.5
Bone: cortical tissue density	0.5	0.8	1.5	-1.2	1.0	0.7	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.1	-0.2	0.6	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	0.1	0.2	-0.6
Condit. Reinf. active responses	0.4	0.5	0.7	-0.5	0.5	0.8	0.8
Condit. Reinf. inactive responses	2.4	3.2	4.8	-1.4	1.9	1.6	2.2
Incentive salience index mean	0.3	0.4	0.9	0.8	-0.9	0.0	0.0
Condit. Reinf. lever presses	0.5	0.8	1.5	1.2	-1.2	-0.1	0.5
Condit. Reinf. active minus inactive responses	1.0	1.6	4.0	1.0	-0.7	-2.0	-1.0
Condit. Reinf. active-inactive response ratio	1.6	2.6	3.9	1.4	-1.2	-2.0	-1.7
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.3	-0.4	0.2
Condit. Reinf. inactive responses	0.4	0.6	1.5	-0.5	0.3	0.8	1.2
Condit. Reinf. lever presses	0.3	0.4	1.5	0.1	0.1	0.1	1.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.5	-0.4	-0.2	0.4
Conditioned reinforcement - actives	0.1	0.4	0.7	-0.6	0.8	-0.1	-0.6
Conditioned reinforcement - inactives	0.2	0.5	1.3	-0.8	1.1	-0.3	-0.0
Conditioned locomotion	0.1	0.2	0.5	0.3	-0.3	-0.1	-0.7
Patch foraging indifference point 0 sec	0.5	1.5	2.0	-1.2	1.4	1.1	1.2
Patch foraging indifference point AUC	0.4	1.0	2.5	0.7	-0.3	-1.6	-0.8
Delay disc. indifference point, 0s delay	1.1	1.3	1.7	0.9	-1.1	-1.2	-1.3
Delay disc. indifference point, 16s delay	0.7	1.0	2.1	-1.4	1.4	0.1	-0.1
Delay disc. indifference point, 2s delay	1.7	1.9	3.9	1.0	-0.2	-1.7	-2.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.3	0.2	0.0	-0.2
Delay disc. indifference point, 4s delay	2.7	2.8	5.0	1.3	-1.3	-1.7	-2.2
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	0.0	0.1	0.5	-0.3
Indifference point function ln k	0.1	0.3	0.5	0.7	-0.6	0.4	-0.1
Indifference point function log k	0.1	0.3	0.5	0.7	-0.6	0.4	-0.1
Patch foraging total patch changes 0 sec	0.5	1.6	2.5	-1.3	1.6	0.9	1.2
Patch foraging total patch changes 12 sec	0.9	1.2	2.0	-1.2	1.4	0.5	1.0
Patch foraging total patch changes 18 sec	1.8	4.3	6.9	-2.2	2.6	1.5	1.8
Patch foraging total patch changes 24 sec	1.5	5.2	6.4	-2.5	1.9	2.3	2.3
Patch foraging total patch changes 6 sec	1.1	1.9	2.8	-1.7	1.7	1.2	0.8
Patch foraging time to switch 0 sec	0.4	1.5	2.8	-1.7	1.3	1.0	0.6
Patch foraging water rate 0 sec	0.0	0.1	0.1	0.3	0.2	-0.2	0.2
Patch foraging water rate 12 sec	0.1	0.5	0.8	-0.8	0.7	0.1	0.9
Patch foraging water rate 18 sec	0.0	0.1	0.3	0.3	0.1	-0.6	-0.0
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.0	0.5	-0.4	0.1
Patch foraging water rate 6 sec	0.3	0.4	0.8	-0.9	0.6	-0.4	0.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	2.1	0.5	-0.6	-1.5	-0.8
Distance traveled before self-admin	0.6	1.3	2.0	1.4	-1.4	-1.0	-0.4
Distance traveled after self-admin	0.8	1.5	1.8	1.3	-1.3	-1.1	-1.1
Extensor digitorum longus weight	0.3	1.3	2.4	1.5	-1.6	0.7	-0.0
Bone: elastic displacement	0.1	0.2	0.3	-0.6	-0.2	-0.3	-0.4
Bone: elastic work	0.4	0.6	1.0	-0.0	-1.0	-0.6	-1.0
Bone: endosteal estimation	4.9	11.9	18.0	4.2	-3.9	-2.3	-3.0
Bone: endosteal perimeter	2.7	6.5	12.2	3.5	-3.2	-1.6	-1.0
Epididymis fat weight	4.2	21.3	39.1	-6.2	6.3	1.6	2.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.3	0.2	-0.3
Delta time in open arm before/after self-admin	0.1	0.2	0.3	0.5	-0.2	-0.5	-0.1
Diff in mean of infusions in LGA sessions	1.3	2.3	4.4	-1.3	1.1	2.1	1.4
Delay discount exponential model param	0.4	0.6	1.9	-0.3	0.2	0.6	1.4
Extinction: sum of active levers before priming	0.4	0.6	0.9	-0.9	0.5	0.8	0.8
Active lever presses in extinction session 6	0.9	0.9	2.9	-1.7	0.8	0.3	0.2
Bone: final force	0.2	0.3	0.7	-0.2	0.3	0.6	-0.8
Bone: final moment	0.1	0.2	0.4	-0.0	0.2	0.5	-0.7
Food consumed during 24 hour testing period	1.2	2.3	2.6	1.6	-1.6	-1.3	-1.6
Glucose	4.0	6.4	11.2	3.3	-3.2	-1.8	-0.8
Heart weight	0.5	0.8	1.6	0.6	-0.3	-1.3	-1.2
Delay discount hyperbolic model param	0.5	0.7	2.1	-0.3	0.1	0.7	1.5
Intermittent access intake day 1-15 change	0.0	0.1	0.2	0.1	0.5	-0.3	-0.2
Intermittent access intake escalation	0.1	0.4	0.7	-0.2	0.8	-0.8	-0.5
Intermittent access intake escalation 2	0.4	0.6	1.5	1.2	-0.5	-0.5	-0.6
Intermitt. access day 1 inactive lever presses	0.1	1.6	2.9	1.5	-1.7	-0.6	-1.0
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.4	1.1	-0.7	-0.5	-1.2
Intermitt. access escalation Index	0.2	0.7	1.7	-0.4	-0.4	1.3	1.0
Intermittent access day 1 total infusions	0.4	1.2	2.2	-1.5	1.3	0.9	0.6
Intermittent access day 15 total infusions	0.4	0.9	1.9	-1.1	1.4	-0.5	-0.2
Intermittent access terminal intake (last 3 days)	0.6	1.1	2.8	-1.2	1.7	-0.4	-0.2
Intermittent access total infusions	0.5	0.6	1.4	-1.0	1.2	-0.5	-0.1
Intermittent access day 1 locomotion	0.1	0.2	0.5	-0.2	-0.1	0.1	-0.7
Intermittent access day 15 total locomotion	0.5	2.1	4.1	0.8	-0.8	-1.7	-2.0
Intermittent access total locomotion	1.5	1.8	3.4	0.6	-0.4	-1.8	-1.8
Intermittent access standard deviation	0.1	0.6	1.0	-0.1	1.0	-0.9	-0.6
Left kidney weight	0.9	7.2	14.7	1.9	-1.6	-3.8	-2.8
Right kidney weight	1.6	11.2	21.0	2.5	-2.1	-4.6	-3.7
Cocaine induced anxiety	0.4	1.2	2.5	1.6	-1.5	-0.1	-0.3
Post-drug Anxiety	0.3	0.3	0.8	0.9	-0.5	-0.1	-0.2
Baseline Anxiety	1.6	2.7	5.1	-1.9	2.3	0.6	1.3
Tail length	3.9	21.1	26.3	4.7	-4.5	-5.1	-4.0
Length with tail	6.1	27.2	34.5	5.9	-5.5	-4.8	-4.6
Length without tail	2.2	11.3	14.1	3.6	-3.4	-2.6	-3.8
Times rat made contact with spout	2.3	2.7	3.8	-1.9	1.5	1.4	1.6
Lifetime Intake	0.3	0.4	0.7	-0.8	0.8	-0.5	-0.2
Liver weight, left	4.4	7.6	11.1	3.3	-3.3	-2.3	-1.8
Liver weight, right	6.6	11.5	13.0	3.6	-3.6	-3.3	-3.0
Locomotor activity	3.4	5.3	9.8	3.1	-2.3	-2.0	-1.5
Locomotor testing distance	0.6	1.6	3.5	1.9	-1.4	-0.7	-0.5
Locomotor testing rearing	0.4	1.5	3.2	1.8	-1.3	-0.5	-0.9
Locomotion in novel chamber	0.2	0.3	0.7	0.4	-0.8	-0.5	-0.1
Locomotion in novel chamber post-restriction	0.1	0.4	0.8	0.1	-0.3	-0.9	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.5	0.8	-0.4	0.4	0.9	0.8
Change in fecal boli incidents, locomotor task	1.3	1.3	2.8	0.7	-0.7	-1.3	-1.7
Time >=10cm from walls, locomotor time 1	1.3	1.6	2.0	1.4	-1.4	-0.9	-1.3
Bouts of movement, locomotor time 1	0.5	0.7	1.5	0.7	-0.7	1.2	0.4
Total resting periods, locomotor time 1	0.5	0.6	0.9	0.9	-0.8	0.9	-0.0
Rest time, locomotor task time 1	0.9	1.5	2.2	1.5	-1.5	0.0	-1.3
Distance moved, locomotor task time 1	0.1	0.3	0.4	-0.6	0.5	-0.1	0.6
Vertical activity count, locomotor time 1	0.0	0.2	0.3	-0.4	0.4	-0.5	0.5
Time >=10cm from walls, locomotor time 2	0.3	0.9	2.0	1.0	-1.4	0.0	-0.7
Bouts of movement, locomotor time 2	1.1	3.5	8.1	2.0	-2.8	-0.8	-1.2
Total resting periods, locomotor time 2	1.0	4.0	9.0	2.3	-3.0	-0.8	-1.2
Rest time, locomotor task time 2	1.9	3.2	6.3	2.5	-2.2	-0.4	-1.2
Distance moved, locomotor task time 2	1.1	1.5	3.0	-1.6	1.7	0.0	0.9
Vertical activity count, locomotor time 2	0.3	0.6	1.0	-1.0	0.8	0.0	0.9
Light reinforcement 1	0.1	0.5	1.1	-0.8	-0.0	1.0	0.5
Light reinforcement 2	0.7	1.6	2.6	1.2	-1.6	-0.9	-1.3
Bone: marrow area	4.7	11.5	17.3	4.2	-3.8	-2.3	-3.0
Bone: maximum diameter	2.0	4.0	7.5	2.7	-2.6	-1.0	-0.8
Bone: maximum force	0.2	0.4	1.1	0.4	-0.4	0.5	-1.1
Bone: maximum moment	0.2	0.4	0.9	0.6	-0.5	0.4	-0.9
Mean time between licks in bursts	0.6	3.4	6.2	2.5	-2.1	-1.3	-1.3
Mean num. licks in bursts	1.1	2.9	4.2	-1.9	1.2	2.1	1.6
Cd content in liver	0.5	0.5	0.7	-0.8	0.6	0.7	0.6
Co content in liver	0.9	1.1	1.7	-1.3	1.3	0.9	0.4
Cu content in liver	2.8	3.3	5.0	-2.2	1.5	1.2	2.2
Fe content in liver	0.2	0.3	1.0	-1.0	0.4	-0.3	-0.2
K content in liver	0.8	0.8	1.3	-0.9	0.9	0.4	1.1
Mg content in liver	0.2	0.2	0.3	0.5	-0.3	-0.3	0.6
Mn content in liver	1.6	1.8	3.8	1.9	-1.7	-0.7	-0.1
Na content in liver	0.9	1.1	2.0	-1.2	1.4	-0.2	0.8
Rb content in liver	0.4	0.5	1.5	-0.5	0.0	0.4	1.2
Se content in liver	3.2	3.8	8.2	2.2	-2.9	-0.9	-1.1
Sr content in liver	1.6	1.4	2.7	0.9	-1.0	-1.6	-0.9
Zn content in liver	0.5	0.5	1.2	0.4	-1.1	0.7	0.6
Bone: minimum diameter	2.8	5.4	9.6	3.0	-3.1	-1.2	-1.4
Time in familiar zone, hab. session 1	4.0	4.4	5.8	-2.3	2.4	1.6	2.0
Time in novel zone, hab. session 1	3.0	3.3	5.3	2.2	-2.3	-1.1	-1.4
Total zone transitions, hab. session 1	0.5	0.7	1.5	-0.5	0.3	1.0	1.2
Total locomotion distance, hab. session 1	0.5	0.7	1.2	-0.7	0.4	1.1	1.0
Locomotion velocity, hab. session 1	0.5	0.6	0.9	-0.9	0.7	0.7	0.9
Time in familiar zone, hab. session 2	1.0	1.1	1.6	-1.0	1.0	0.9	1.3
Time in novel zone, hab. session 2	0.4	0.5	0.9	0.7	-0.6	-0.4	-1.0
Total zone transitions, hab. session 2	0.4	0.4	1.0	-0.7	1.0	0.1	0.5
Total locomotion distance, hab. session 2	0.9	1.2	1.4	-1.1	1.2	0.9	1.2
Locomotion velocity, hab. session 2	0.9	1.1	1.7	-1.0	1.1	0.8	1.3
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.4	0.3	0.3	-0.2
Novelty place preference	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.4
Time in novel zone, NPP test	0.1	0.1	0.4	0.0	-0.3	-0.1	-0.6
Total zone transitions, NPP test	0.6	0.8	1.7	-0.4	0.2	1.2	1.3
Total locomotion distance, NPP test	0.9	1.3	1.7	-1.1	0.9	1.3	1.3
Locomotion velocity, NPP test	1.6	2.2	3.1	-1.4	1.1	1.6	1.8
Intraocular pressure	0.2	0.3	0.7	-0.3	0.1	0.7	0.8
Delta distance traveled before/after self-admin	0.3	0.3	1.1	0.0	-0.1	-0.2	-1.0
Delta ambulatory time before/after self-admin	0.2	0.3	0.9	0.3	-0.3	-0.4	-0.9
Parametrial fat weight	0.4	1.0	2.3	0.5	-0.4	-1.5	-1.1
Pavlov. Cond. lever latency	1.9	2.4	4.8	-2.2	1.9	0.7	0.8
Pavlov. Cond. magazine entry latency	1.4	1.8	2.8	1.7	-1.6	-1.4	-0.5
Pavlov. Cond. change in total contacts	2.3	2.5	3.6	1.9	-1.5	-1.3	-1.5
Pavlov. Cond. index score	2.0	2.6	4.6	2.1	-2.0	-1.1	-0.8
Pavlov. Cond. latency score	2.3	3.0	5.0	2.2	-2.1	-1.4	-0.9
Pavlov. Cond. lever contacts	2.2	2.6	4.9	2.2	-2.0	-0.9	-1.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.5	-1.2	1.2	1.1	0.1
Pavlov. Cond. intertrial magazine entries	2.6	3.1	4.4	-1.8	1.6	2.1	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	4.0	2.0	-1.9	-0.7	-0.6
Pavlov. Cond. response bias	1.5	1.9	3.4	1.9	-1.7	-0.9	-0.5
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.6	-0.6	-0.3	-1.0
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	0.7	-0.7	-0.9	-0.7
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.2	0.1	-0.5	-0.1
Pavlov. Cond. index score	0.1	0.1	0.3	0.3	-0.2	-0.5	0.0
Pavlov. Cond. latency score	0.0	0.1	0.3	0.1	-0.1	-0.5	0.0
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.5	0.5	-0.1	0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	-0.4	0.3	0.8	0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.5	1.2	1.1	-0.8	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	0.2	-0.2	-0.3	0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	0.2	-0.1	-0.4	0.3
Time in closed arm before self-admin	0.2	0.3	0.8	-0.4	0.9	-0.4	-0.0
Time in closed arm after self-admin	0.8	0.9	1.9	-1.1	1.4	-0.4	-0.5
Time in open arm before self-admin	0.2	0.2	0.6	0.4	-0.7	-0.3	0.1
Time in open arm after self-admin	0.5	0.5	1.0	1.0	-0.9	-0.2	0.4
Bone: periosteal estimation	2.7	6.4	9.8	3.1	-3.0	-1.3	-2.3
Bone: periosteal perimeter	1.7	3.3	6.3	2.5	-2.2	-0.8	-1.3
Bone: post-yield work	1.4	2.5	6.0	2.4	-2.0	-0.1	-0.4
Progressive ratio test 1 active lever presses	0.4	0.7	1.4	-1.2	1.0	-0.6	0.1
Progressive ratio test 1 breakpoint	0.4	0.7	1.3	-1.1	1.0	-0.7	0.0
Progressive ratio test 1 inactive lever presses	0.9	2.3	4.3	-1.9	2.1	-0.1	1.1
Progressive ratio test 2 active lever presses	1.0	1.4	2.6	-1.6	1.6	0.6	0.3
Progressive ratio test 2 breakpoint	1.1	1.5	2.8	-1.7	1.7	0.5	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	-0.1	0.8	0.1	-0.5
Incentive Sensitization - Responses	0.4	1.0	1.3	-1.1	1.1	1.1	0.4
Incentive Sensitization - Breakpoint	0.5	1.1	1.7	-1.2	1.1	1.3	0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1
Progressive ratio	0.9	2.8	7.0	0.0	0.8	-2.6	-1.8
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.3
Seeking ratio, punishment vs. effort	1.0	2.1	4.7	-0.1	-1.0	2.2	1.7
Retroperitoneal fat weight	0.2	1.0	2.5	0.5	-0.3	-1.6	-0.9
Reaction time number correct	0.5	1.9	5.0	-1.5	2.2	0.3	0.4
Reaction time mean minus median	1.1	7.1	10.9	3.3	-3.3	-2.0	-1.6
Reaction time mean minus median AUC	0.7	4.7	7.6	2.8	-2.5	-1.8	-1.3
Reaction time num false alarms	0.2	0.3	0.4	0.6	-0.4	0.3	-0.6
Reaction time num false alarms AUC	0.1	0.3	0.6	0.8	-0.4	0.1	-0.7
Reaction time trials correct on left	0.5	1.9	5.0	-1.5	2.2	0.3	0.4
Reaction time trials on left	0.5	1.7	4.6	-1.4	2.1	0.2	0.3
Reaction time mean	2.5	5.5	9.7	3.1	-2.9	-1.5	-1.3
Reaction time mean AUC	2.5	5.9	10.1	3.2	-3.0	-1.7	-1.4
Median of all reaction times	2.0	3.2	5.9	2.4	-2.1	-1.1	-1.0
Reaction time omissions	2.4	4.0	6.6	2.6	-2.1	-1.5	-1.6
Reaction time false alarm rate	1.1	1.5	2.6	1.6	-1.6	-0.1	-0.8
Reaction time premature initiation rate	0.4	0.7	1.5	0.3	-0.8	-1.2	-0.7
Reaction time premature initiations	0.2	0.5	0.9	-0.6	0.5	-0.9	-0.7
Std. dev. reaction times	2.5	8.2	12.6	3.5	-3.5	-2.1	-2.0
Reaction time trials completed	0.5	1.7	4.6	-1.4	2.1	0.2	0.3
Reaction time trials AUC	0.5	1.9	5.2	-1.5	2.3	0.2	0.4
Run reversals in cocaine runway, females	0.7	0.8	1.3	-0.8	0.5	1.1	1.0
Run reversals in cocaine runway, males	4.6	5.0	8.1	2.6	-2.8	-1.4	-1.8
Latency to leave start box in cocaine runway	0.2	0.2	0.5	-0.1	0.7	0.2	-0.5
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	0.1	0.7	0.9	0.3
Latency to leave start box in cocaine runway, M	1.0	1.0	2.4	-0.1	0.4	-1.2	-1.5
Std. dev. time between licks in bursts	1.9	3.5	6.5	2.6	-2.2	-1.0	-1.3
Total sessions with >9 infusions	0.2	0.2	0.6	-0.8	0.4	0.1	-0.3
Short access day 1 total inactive lever presses	1.1	2.2	2.9	1.5	-1.5	-1.7	-1.2
Short access day 10 total inactive lever presses	0.0	0.3	0.8	0.3	-0.2	0.4	0.9
Short access day 1 total infusions	0.1	0.2	0.3	-0.5	0.5	0.3	0.5
Short access day 10 total infusions	0.2	0.3	0.7	-0.8	0.7	0.2	-0.2
Short access total infusions	0.2	0.3	0.6	-0.8	0.7	-0.1	-0.0
Short access day 1 locomotion	0.5	0.8	1.5	-0.7	0.5	1.2	1.0
Short access day 10 total locomotion	0.4	1.8	2.8	1.4	-1.7	-1.0	-1.2
Short access total locomotion	0.2	0.2	0.5	0.2	-0.6	-0.1	-0.7
One hour access (0.3 mA shock)	0.7	0.9	1.3	-0.9	0.9	0.8	1.1
Compulsive drug intake	0.5	0.8	2.0	0.3	-0.7	1.4	0.8
One hour access (shock baseline)	0.1	0.4	0.7	-0.4	0.7	-0.9	-0.1
Social response proportion	0.2	0.3	0.6	0.8	-0.7	-0.2	-0.0
Social responses	0.1	0.2	0.5	0.3	-0.1	-0.7	0.2
Social time	3.0	4.7	8.6	2.4	-2.9	-1.3	-1.6
Soleus weight	3.0	8.9	17.2	3.9	-4.1	-0.7	-1.7
Bone: stiffness	0.6	1.1	4.0	-0.6	0.4	2.0	0.1
Tibialis anterior weight	0.5	1.7	3.0	-1.6	0.8	1.7	0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.4	0.4	0.0	0.0
Time to tail flick, vehicle, after self-admin	0.1	0.3	0.7	0.4	-0.8	0.3	0.4
Time to tail flick, test, before self-admin	0.0	0.1	0.1	-0.2	0.2	-0.2	0.3
Time to tail flick, test, after self-admin	0.4	0.5	1.0	0.5	-0.7	-1.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.6	-0.6	0.7	0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.5	0.3	0.6	0.4
Tibia length	2.8	7.9	10.8	3.3	-2.7	-2.3	-2.8
Ambulatory time before self-admin	0.2	0.5	0.7	0.8	-0.9	-0.6	-0.3
Ambulatory time after self-admin	0.7	1.1	1.3	1.1	-1.1	-0.9	-1.0
Bone: tissue strength	0.1	0.1	0.3	0.1	-0.3	0.3	-0.5
Total heroin consumption	0.3	0.3	0.7	0.5	-0.8	-0.6	-0.1
Bone: trabecular number	1.9	3.5	7.5	-1.7	0.6	2.7	1.8
Bone: trabecular spacing	2.8	4.1	7.1	1.7	-1.2	-2.7	-2.2
Bone: trabecular thickness	1.4	1.9	3.0	-1.1	0.9	1.7	1.6
Bone: trabecular tissue density	0.3	0.5	1.0	0.2	0.6	-0.7	-1.0
Water consumed over 24 hours	0.1	0.3	0.6	0.4	-0.8	-0.2	-0.5
Number of responses in last shaping day	0.1	0.1	0.2	0.5	0.1	-0.5	0.0