Hub : Genes

Trank1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Trank1 0.58 0.13 0.0e+00 0.43 0.48 0.5 0.49 2.2e-52 6.4e-61 5.9e-64 2.3e-62
2 Liver gene expression Trank1 0.35 0.12 0.0e+00 0.31 0.34 0.34 0.34 1.4e-34 1.7e-38 1.8e-39 6.4e-39
3 Brain intron excision ratio chr8_120219593_120222781 0.06 0.04 3.2e-06 0.06 0.04 0.04 0.04 1.4e-06 1.1e-04 7.6e-05 4.3e-05
4 NAcc gene expression Trank1 0.02 0.01 4.7e-05 0.03 0.03 0.02 0.03 1.1e-05 7.8e-05 3.1e-04 2.3e-05
5 NAcc intron excision ratio chr8_120219593_120221549 0.02 0.02 7.8e-05 0.02 0.01 0.02 0.02 2.3e-04 1.8e-03 8.3e-04 1.2e-03
6 PL intron excision ratio chr8_120219593_120222781 0.02 0.01 9.5e-03 0.01 0.01 0.01 0.01 2.0e-02 1.0e-02 1.1e-02 4.3e-02
7 NAcc intron excision ratio chr8_120219593_120222781 0.05 0.03 6.5e-10 0.07 0.06 0.06 0.06 1.7e-10 1.1e-09 1.1e-09 4.4e-10
8 Brain intron excision ratio chr8_120221634_120222781 0.02 0.02 8.6e-03 0.02 0.01 0 0.01 6.2e-03 2.9e-02 3.0e-01 1.9e-02
9 Adipose isoform ratio XM_039081617.2 0.03 0.02 4.1e-04 0.03 0.02 0.02 0.02 6.7e-04 1.1e-03 2.5e-03 1.2e-03
10 Adipose alternative TSS XM_039081614.2 0.04 0.02 9.5e-05 0.03 0.01 0.01 0.02 6.1e-04 9.1e-03 8.5e-03 5.9e-03
11 Brain gene expression Trank1 0.11 0.08 3.1e-05 0.06 0.04 0.04 0.05 4.1e-06 6.8e-05 1.0e-04 1.8e-05
12 Brain intron excision ratio chr8_120221833_120222781 0.03 0.02 6.8e-03 -0 0 0 -0 4.6e-01 1.5e-01 2.5e-01 4.5e-01
13 LHb isoform ratio XM_039081614.2 0.34 0.15 1.0e-03 0.09 0.1 0.08 0.06 3.8e-03 2.4e-03 5.8e-03 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.21.30.20.0-0.10.10.1-0.1-0.1-0.40.2-0.40.40.81.2
Area under the delay curve1.61.93.21.81.71.4-1.2-1.41.41.4-1.4-1.4-1.41.4-0.60.9
BMI with tail0.31.14.0-0.6-0.5-1.11.11.1-0.8-0.82.00.91.5-1.50.4-0.1
BMI without tail0.72.24.9-1.1-1.1-1.51.51.5-1.4-1.12.21.21.8-1.81.51.1
Body weight5.222.728.9-5.1-4.9-5.35.45.3-5.0-4.95.34.94.8-4.83.7-0.0
Weight adjusted by age0.10.11.2-0.3-0.20.0-0.1-0.10.00.10.30.10.3-0.3-0.6-1.1
Bone surface0.10.20.60.50.40.3-0.3-0.30.40.5-0.7-0.4-0.80.8-0.10.2
Bone volume0.10.10.40.30.20.1-0.1-0.10.20.2-0.5-0.2-0.60.60.20.5
Breakpoint value in progressive ratio session0.30.30.80.40.30.5-0.3-0.50.40.5-0.9-0.6-0.90.90.00.2
Number of licking bursts0.20.31.80.10.20.5-0.5-0.50.50.40.0-0.40.2-0.2-1.1-1.3
Context. condit. distance diff. score0.10.10.4-0.1-0.1-0.10.10.10.00.1-0.5-0.1-0.60.6-0.2-0.6
Locomotion velocity, session 10.10.10.40.20.30.2-0.1-0.10.10.5-0.1-0.6-0.10.10.10.6
Locomotion distance, session 10.81.03.0-0.8-0.9-1.21.21.2-1.1-0.70.30.60.0-0.01.71.4
Locomotion velocity, session 20.40.41.10.60.50.5-0.5-0.50.60.6-0.8-0.7-1.11.1-0.3-0.1
Locomotion distance, session 20.20.32.80.40.2-0.10.20.2-0.10.2-0.0-0.3-0.30.31.01.7
Locomotion velocity, session 30.30.31.8-0.0-0.2-0.50.50.5-0.4-0.00.20.1-0.10.11.21.3
Locomotion distance, session 30.90.92.31.10.90.6-0.7-0.70.80.9-1.3-0.8-1.51.50.20.9
Stereotopy head waving bouts, day 30.50.64.0-0.6-0.2-0.20.20.2-0.0-0.20.80.10.8-0.8-1.2-2.0
Stereotopy head waving duration, day 30.50.61.6-0.8-0.5-0.50.50.5-0.4-0.61.10.51.2-1.2-0.6-1.1
Locomotion velocity, session 70.60.62.4-0.5-0.7-0.70.70.7-0.8-0.60.30.70.3-0.31.51.5
Locomotion distance, session 70.50.61.50.90.80.6-0.6-0.60.60.7-0.8-0.6-0.90.90.21.2
Stereotopy head waving bouts, day 70.20.20.70.50.40.3-0.3-0.30.30.4-0.4-0.4-0.40.40.30.9
Stereotopy head waving duration, day 70.20.20.8-0.3-0.4-0.40.40.4-0.4-0.30.20.30.1-0.10.90.9
Locomotion velocity, session 80.30.41.3-0.4-0.7-0.70.80.8-0.6-0.3-0.30.2-0.60.61.10.5
Locomotion distance, session 80.50.73.3-0.2-0.3-0.80.80.8-0.7-0.2-0.00.2-0.40.41.71.8
Degree of sensitization distance1.21.32.1-1.3-1.1-1.01.01.0-1.1-1.21.31.11.5-1.50.70.2
Degree of sensitization stereotypy0.40.42.80.40.30.2-0.2-0.20.10.2-0.5-0.2-0.50.50.91.7
Conditioned locomotion3.13.55.02.22.12.0-2.0-2.02.01.9-2.1-1.9-2.02.0-1.20.4
Cocaine response after cond. corrected0.70.82.6-0.8-0.5-0.50.50.5-0.4-0.51.40.51.6-1.6-0.6-1.1
Cocaine response after cond. not corrected2.22.55.6-1.7-1.5-1.41.41.4-1.3-1.32.21.32.4-2.40.2-1.0
Cocaine response before conditioning0.91.11.7-1.1-1.2-1.31.31.3-1.2-0.90.81.00.5-0.51.30.3
Saline control response0.70.91.4-0.9-1.0-0.90.90.9-1.0-1.20.81.10.9-0.91.20.9
Bone: connectivity density0.50.71.41.01.00.8-0.8-0.80.70.7-1.1-0.6-1.01.00.11.2
Bone: cortical apparent density0.60.82.50.70.70.6-0.6-0.60.60.7-1.6-0.7-1.51.5-0.10.4
Bone: cortical area0.20.32.3-0.0-0.00.4-0.4-0.40.40.3-0.1-0.3-0.20.2-0.9-1.5
Bone: cortical porosity0.50.54.30.70.60.5-0.5-0.50.20.2-0.3-0.3-0.10.10.82.1
Bone: cortical porosity0.40.43.80.50.40.4-0.4-0.40.10.1-0.1-0.10.2-0.20.82.0
Bone: cortical thickness0.30.53.4-0.8-0.8-0.40.40.4-0.3-0.50.10.50.0-0.0-0.5-1.8
Bone: cortical thickness0.00.00.0-0.1-0.2-0.10.10.1-0.1-0.1-0.00.1-0.00.00.0-0.2
Bone: cortical tissue density0.60.92.70.70.60.6-0.6-0.60.60.7-1.6-0.7-1.61.6-0.10.4
Condit. Reinf. active minus inactive responses0.10.10.2-0.5-0.5-0.20.30.3-0.3-0.40.10.40.3-0.3-0.1-0.5
Condit. Reinf. active-inactive response ratio0.30.30.7-0.8-0.7-0.40.40.4-0.4-0.70.30.70.6-0.6-0.2-0.8
Condit. Reinf. active responses0.00.00.20.20.10.3-0.2-0.20.30.2-0.1-0.2-0.00.0-0.4-0.3
Condit. Reinf. inactive responses0.60.81.51.21.10.9-0.9-0.90.91.1-0.6-1.1-0.70.7-0.50.4
Incentive salience index mean0.00.10.10.20.20.2-0.2-0.20.20.2-0.3-0.2-0.30.3-0.3-0.1
Condit. Reinf. lever presses1.11.52.21.51.51.3-1.2-1.21.31.4-1.1-1.4-1.31.3-0.80.3
Condit. Reinf. active minus inactive responses1.31.72.9-1.7-1.7-1.61.61.6-1.4-1.40.81.50.6-0.60.9-0.7
Condit. Reinf. active-inactive response ratio1.41.72.7-1.5-1.4-1.41.41.4-1.3-1.21.61.31.4-1.40.6-0.5
Condit. Reinf. active responses1.01.32.6-1.6-1.5-1.41.41.4-1.3-1.30.61.30.5-0.50.6-0.9
Condit. Reinf. inactive responses0.30.41.20.20.30.4-0.4-0.40.40.3-1.1-0.5-1.01.0-0.6-0.8
Condit. Reinf. lever presses1.62.23.5-1.9-1.8-1.81.81.8-1.7-1.70.91.70.6-0.61.4-0.0
Condit. Reinf. lever reinforcers received1.31.83.3-1.8-1.7-1.61.61.6-1.5-1.50.81.50.7-0.70.8-0.8
Conditioned reinforcement - actives1.11.93.31.41.61.1-1.2-1.01.41.6-1.4-1.8-1.61.6-1.4-0.4
Conditioned reinforcement - inactives1.92.95.71.31.61.4-1.8-1.41.72.2-1.2-1.8-1.51.5-2.4-1.9
Conditioned locomotion0.40.51.10.60.70.5-0.4-0.40.50.7-0.6-0.9-0.90.9-0.01.1
Patch foraging indifference point 0 sec1.01.92.9-1.4-1.5-1.41.41.4-1.5-1.71.11.61.2-1.21.70.8
Patch foraging indifference point AUC0.30.52.60.20.0-0.20.30.2-0.2-0.3-0.80.3-0.80.81.21.6
Delay disc. indifference point, 0s delay0.10.10.30.00.0-0.10.50.1-0.1-0.50.50.40.6-0.60.20.2
Delay disc. indifference point, 16s delay0.91.01.61.31.21.0-1.0-1.01.01.2-1.1-1.0-1.01.0-0.40.6
Delay disc. indifference point, 2s delay0.30.30.50.70.70.5-0.3-0.60.60.6-0.6-0.6-0.60.6-0.30.2
Delay disc. indifference point, 24s delay1.11.21.81.41.30.9-0.8-0.91.01.3-1.2-1.3-1.31.3-0.50.6
Delay disc. indifference point, 4s delay1.71.82.71.61.61.4-1.1-1.41.41.1-1.5-1.4-1.41.4-0.90.2
Delay disc. indifference point, 8s delay1.61.93.51.91.71.4-1.4-1.51.41.4-1.3-1.3-1.31.3-0.60.9
Indifference point function ln k0.20.30.50.40.50.3-0.3-0.30.40.60.7-0.70.4-0.4-0.7-0.6
Indifference point function log k0.20.30.50.40.50.3-0.3-0.30.40.60.7-0.70.4-0.4-0.7-0.6
Patch foraging total patch changes 0 sec1.22.23.2-1.5-1.6-1.51.51.5-1.6-1.81.31.71.4-1.41.50.5
Patch foraging total patch changes 12 sec0.60.81.3-1.1-1.1-1.11.11.0-1.0-1.0-0.20.9-0.00.01.10.4
Patch foraging total patch changes 18 sec2.13.15.2-1.9-2.1-2.01.82.0-2.0-2.10.92.01.0-1.02.30.9
Patch foraging total patch changes 24 sec1.73.04.4-2.1-2.0-2.01.81.9-1.9-1.91.41.81.3-1.31.70.3
Patch foraging total patch changes 6 sec0.20.31.7-0.3-0.4-0.30.30.2-0.4-0.7-0.10.5-0.00.01.11.3
Patch foraging time to switch 0 sec0.30.51.30.40.50.7-0.8-0.80.70.8-0.5-0.9-0.40.4-1.1-0.8
Patch foraging water rate 0 sec0.20.40.8-0.7-0.7-0.70.80.8-0.7-0.90.20.80.2-0.20.4-0.5
Patch foraging water rate 12 sec0.20.50.9-0.8-0.7-0.60.60.6-0.7-0.70.90.60.9-0.90.4-0.0
Patch foraging water rate 18 sec0.61.03.7-0.5-0.5-0.40.50.4-0.4-0.61.90.81.6-1.6-0.4-1.0
Patch foraging water rate 24 sec0.81.11.8-1.1-1.2-0.81.11.0-1.0-1.31.21.31.2-1.20.5-0.5
Patch foraging water rate 6 sec0.30.50.9-0.8-0.9-0.80.80.8-0.8-0.70.40.70.2-0.21.00.2
Seeking ratio, delayed vs. immediate footshock1.11.33.11.81.71.3-1.1-1.31.31.0-0.7-0.8-0.80.8-0.61.1
Distance traveled before self-admin0.30.42.30.30.40.6-0.5-0.60.5-0.10.1-0.10.1-0.1-1.3-1.5
Distance traveled after self-admin0.50.61.10.30.40.5-0.4-0.40.61.0-1.0-1.0-1.01.0-0.8-0.9
Extensor digitorum longus weight0.10.51.50.60.80.7-0.7-0.70.80.7-0.2-0.6-0.40.4-1.2-0.9
Bone: elastic displacement0.20.21.4-0.5-0.3-0.20.30.3-0.2-0.30.10.30.2-0.2-0.4-1.2
Bone: elastic work0.40.61.5-1.0-1.0-0.90.90.9-0.7-0.70.30.60.1-0.10.2-1.2
Bone: endosteal estimation0.20.41.0-0.5-0.6-0.40.30.3-0.5-0.40.90.51.0-1.00.70.6
Bone: endosteal perimeter0.81.62.71.61.51.6-1.6-1.61.41.6-0.3-1.5-0.40.4-1.10.1
Epididymis fat weight0.51.72.7-1.1-1.1-1.31.31.4-1.2-1.51.61.51.6-1.60.9-0.1
Delta time in closed arm before/after self-admin0.20.20.50.70.50.7-0.6-0.60.50.30.00.10.0-0.0-0.20.5
Delta time in open arm before/after self-admin0.20.20.4-0.6-0.5-0.50.40.5-0.50.1-0.6-0.2-0.60.60.50.0
Diff in mean of infusions in LGA sessions0.30.32.9-0.4-0.2-0.10.20.00.10.0-0.20.0-0.20.2-1.0-1.7
Delay discount exponential model param1.92.13.6-1.9-1.8-1.41.21.5-1.5-1.51.51.51.5-1.50.6-0.8
Extinction: sum of active levers before priming0.30.31.50.20.1-0.10.30.1-0.2-0.30.70.60.7-0.70.61.2
Active lever presses in extinction session 60.50.50.9-0.2-0.3-0.50.70.6-0.5-0.90.80.80.8-0.80.71.0
Bone: final force1.01.63.0-1.6-1.7-1.31.21.2-1.3-1.11.31.31.1-1.10.7-0.9
Bone: final moment1.32.03.5-1.8-1.9-1.41.41.4-1.5-1.31.61.41.5-1.50.7-1.0
Food consumed during 24 hour testing period1.62.24.0-1.6-1.5-1.41.41.4-1.4-1.42.01.41.9-1.90.8-0.2
Glucose0.91.43.0-1.0-1.2-1.21.21.2-1.3-1.00.91.10.7-0.71.71.5
Heart weight2.23.44.4-2.1-1.9-1.81.91.9-1.7-1.92.02.02.0-2.00.3-1.7
Delay discount hyperbolic model param2.12.33.8-2.0-1.9-1.51.31.6-1.6-1.51.61.61.6-1.60.8-0.7
Intermittent access intake day 1-15 change0.61.22.50.91.10.9-0.9-0.91.11.0-0.9-1.1-1.11.1-1.6-1.2
Intermittent access intake escalation0.81.73.41.11.31.1-1.1-1.11.31.3-1.2-1.4-1.41.4-1.8-1.4
Intermittent access intake escalation 20.50.63.10.00.40.2-0.2-0.20.50.6-0.5-0.7-0.60.6-1.4-1.7
Intermitt. access day 1 inactive lever presses0.10.30.80.20.30.4-0.6-0.60.40.40.4-0.10.3-0.3-0.9-0.9
Intermitt. access day 15 inactive lever presses1.22.54.91.31.41.6-1.6-1.61.61.6-1.1-1.6-1.21.2-2.2-2.1
Intermitt. access escalation Index0.20.32.20.3-0.00.0-0.3-0.3-0.1-0.50.30.60.4-0.40.91.5
Intermittent access day 1 total infusions0.10.20.20.50.50.4-0.3-0.20.40.4-0.4-0.3-0.40.4-0.4-0.2
Intermittent access day 15 total infusions1.11.62.61.21.41.1-1.1-1.11.31.3-1.2-1.2-1.41.4-1.6-1.0
Intermittent access terminal intake (last 3 days)0.70.91.41.01.20.9-0.9-0.91.01.1-0.8-1.0-0.90.9-1.2-0.5
Intermittent access total infusions1.01.22.11.11.31.1-1.0-1.01.21.1-0.9-1.0-1.11.1-1.4-0.9
Intermittent access day 1 locomotion0.10.10.8-0.3-0.2-0.20.40.2-0.30.00.1-0.1-0.00.00.60.9
Intermittent access day 15 total locomotion0.20.30.80.50.60.5-0.4-0.50.50.8-0.5-0.9-0.60.6-0.40.3
Intermittent access total locomotion0.60.81.21.01.00.8-0.7-0.80.81.1-0.8-1.1-1.01.0-0.50.5
Intermittent access standard deviation0.40.75.4-0.5-0.1-0.1-0.2-0.00.20.6-0.5-0.7-0.70.7-1.4-2.3
Left kidney weight0.83.65.8-1.7-1.6-2.01.81.9-1.9-1.82.41.82.1-2.11.81.2
Right kidney weight0.52.54.8-1.2-1.0-1.51.51.5-1.4-1.52.21.42.1-2.11.31.2
Cocaine induced anxiety0.00.00.1-0.2-0.1-0.20.10.2-0.10.10.2-0.30.2-0.2-0.2-0.4
Post-drug Anxiety0.10.10.30.20.40.1-0.1-0.20.20.4-0.2-0.5-0.20.2-0.3-0.1
Baseline Anxiety0.10.10.30.40.40.3-0.0-0.40.30.1-0.40.0-0.40.40.10.5
Tail length3.915.120.6-4.5-4.5-4.34.34.3-4.3-4.13.34.03.3-3.33.80.8
Length with tail7.934.146.4-6.8-6.6-6.56.56.5-6.2-6.45.56.25.4-5.44.5-0.4
Length without tail7.724.730.4-5.5-5.3-5.45.45.4-5.1-5.55.25.55.0-5.03.3-1.0
Times rat made contact with spout0.30.40.6-0.7-0.6-0.60.60.6-0.6-0.60.70.60.8-0.80.2-0.1
Lifetime Intake1.11.42.01.31.41.3-1.1-1.11.31.3-1.0-1.2-1.21.2-1.3-0.3
Liver weight, left0.40.71.2-0.9-0.9-0.90.80.9-0.9-1.00.60.90.6-0.61.10.6
Liver weight, right1.42.53.3-1.5-1.5-1.71.51.6-1.6-1.71.81.81.8-1.81.40.6
Locomotor activity5.48.512.5-3.5-3.4-3.33.23.3-3.2-2.82.72.82.7-2.72.4-0.1
Locomotor testing distance4.37.712.3-3.5-3.3-3.13.13.1-3.1-2.62.62.42.7-2.72.2-0.2
Locomotor testing rearing0.20.50.9-1.0-0.8-0.50.60.5-0.6-0.60.70.50.9-0.90.1-0.5
Locomotion in novel chamber0.30.31.30.20.30.3-0.2-0.30.40.2-0.6-0.3-0.70.7-0.8-1.1
Locomotion in novel chamber post-restriction0.40.71.5-0.7-0.8-1.01.00.9-0.9-0.80.40.90.4-0.41.20.7
Fecal boli incidents, locomotor time 10.30.41.0-0.9-0.9-0.70.60.5-0.7-0.90.31.00.3-0.30.4-0.5
Change in fecal boli incidents, locomotor task0.00.00.10.10.0-0.00.20.1-0.0-0.20.1-0.00.0-0.00.20.3
Time >=10cm from walls, locomotor time 10.30.30.70.60.40.6-0.8-0.80.40.5-0.2-0.5-0.10.10.10.9
Bouts of movement, locomotor time 10.10.10.2-0.2-0.2-0.00.10.1-0.10.0-0.40.0-0.50.50.1-0.1
Total resting periods, locomotor time 10.00.00.1-0.2-0.2-0.00.10.1-0.1-0.0-0.30.1-0.30.30.1-0.1
Rest time, locomotor task time 10.30.31.01.01.00.7-0.5-0.60.70.3-0.1-0.3-0.10.1-0.50.4
Distance moved, locomotor task time 10.81.22.6-1.6-1.6-1.21.21.2-1.2-1.00.80.90.9-0.90.6-1.0
Vertical activity count, locomotor time 10.20.51.3-1.0-1.1-0.80.60.7-0.8-0.60.40.60.4-0.40.6-0.3
Time >=10cm from walls, locomotor time 21.01.52.5-1.4-1.5-1.01.11.0-1.2-1.61.11.51.2-1.21.10.1
Bouts of movement, locomotor time 20.10.21.2-0.4-0.4-0.30.50.4-0.2-0.40.30.50.3-0.3-0.3-1.1
Total resting periods, locomotor time 20.10.10.8-0.2-0.1-0.20.40.2-0.0-0.30.10.30.1-0.1-0.3-0.9
Rest time, locomotor task time 20.00.00.10.30.2-0.00.20.20.1-0.1-0.2-0.0-0.20.20.20.3
Distance moved, locomotor task time 20.50.61.4-1.2-1.1-0.80.80.8-0.8-0.80.80.80.8-0.80.2-0.6
Vertical activity count, locomotor time 20.00.00.1-0.3-0.20.1-0.2-0.1-0.10.10.1-0.10.1-0.1-0.1-0.0
Light reinforcement 10.41.01.9-0.9-0.9-1.00.91.0-1.0-1.01.40.71.2-1.21.00.6
Light reinforcement 20.30.53.10.80.70.4-0.3-0.30.30.30.7-0.20.4-0.40.61.8
Bone: marrow area0.20.41.0-0.5-0.6-0.40.40.4-0.6-0.50.90.51.0-1.00.70.7
Bone: maximum diameter0.30.61.30.60.60.8-0.8-0.80.80.8-0.5-0.9-0.60.6-1.1-1.0
Bone: maximum force0.81.32.4-1.4-1.5-1.11.11.1-1.2-1.11.31.21.2-1.20.9-0.3
Bone: maximum moment0.91.62.5-1.5-1.6-1.21.21.2-1.3-1.21.61.21.5-1.50.8-0.4
Mean time between licks in bursts0.51.32.21.11.31.2-1.2-1.21.21.3-0.8-1.3-0.80.8-1.5-0.8
Mean num. licks in bursts0.40.71.9-0.6-0.7-0.80.80.8-0.8-0.80.50.80.4-0.41.31.4
Cd content in liver0.10.10.50.40.50.2-0.2-0.20.20.30.0-0.30.0-0.00.00.7
Co content in liver1.01.12.40.90.91.2-1.2-1.21.21.1-0.6-0.9-0.60.6-1.5-1.2
Cu content in liver3.74.46.6-2.3-2.6-2.22.22.2-2.3-2.22.12.12.1-2.11.90.0
Fe content in liver0.91.12.7-1.4-1.7-1.01.01.0-1.1-1.30.21.30.4-0.40.6-0.9
K content in liver0.50.52.0-0.3-0.6-0.40.50.4-0.4-0.3-1.00.2-1.41.40.70.1
Mg content in liver1.51.55.01.00.80.7-0.7-0.70.81.1-1.7-1.1-2.22.2-0.30.0
Mn content in liver0.40.52.00.1-0.1-0.30.30.3-0.20.1-0.8-0.1-1.41.40.90.9
Na content in liver0.40.41.0-0.8-1.0-0.40.50.4-0.6-0.8-0.70.6-0.50.50.5-0.4
Rb content in liver0.81.01.9-1.3-1.3-0.60.50.6-0.8-1.10.71.21.1-1.1-0.2-1.4
Se content in liver0.20.31.3-0.0-0.2-0.20.20.2-0.00.0-0.8-0.1-1.21.20.2-0.2
Sr content in liver0.30.21.30.40.3-0.30.30.3-0.10.40.5-0.4-0.20.20.71.1
Zn content in liver2.52.83.9-1.7-1.8-1.61.71.6-1.7-1.52.01.61.9-1.91.70.6
Bone: minimum diameter0.30.50.80.70.80.9-0.9-0.90.70.80.2-0.70.1-0.1-0.8-0.3
Time in familiar zone, hab. session 11.21.12.40.91.01.1-1.1-1.11.10.8-1.2-0.9-0.80.8-1.6-1.3
Time in novel zone, hab. session 10.40.41.2-0.6-0.5-0.60.60.6-0.6-0.21.10.20.9-0.90.50.4
Total zone transitions, hab. session 10.91.23.0-0.6-0.6-1.11.11.1-1.0-0.61.30.51.0-1.01.61.7
Total locomotion distance, hab. session 10.30.40.8-0.3-0.4-0.70.70.7-0.6-0.40.50.50.4-0.40.90.9
Locomotion velocity, hab. session 10.30.51.5-0.3-0.5-0.80.70.7-0.7-0.50.30.50.1-0.11.21.2
Time in familiar zone, hab. session 20.90.92.00.30.50.6-0.6-0.60.70.5-1.4-0.6-1.41.4-1.1-1.4
Time in novel zone, hab. session 20.40.41.5-0.0-0.0-0.10.10.1-0.2-0.11.10.21.2-1.20.30.9
Total zone transitions, hab. session 20.20.31.2-0.2-0.1-0.50.50.5-0.4-0.00.70.00.4-0.40.81.1
Total locomotion distance, hab. session 20.30.31.1-0.4-0.5-0.70.70.7-0.6-0.50.20.5-0.10.11.00.9
Locomotion velocity, hab. session 20.20.31.1-0.2-0.4-0.50.50.5-0.5-0.3-0.10.3-0.40.41.01.0
Novel to familiar place preference ratio1.71.86.9-0.6-0.9-1.01.01.0-1.2-1.21.11.21.1-1.12.22.6
Novelty place preference1.71.87.5-0.6-0.9-1.01.01.0-1.2-1.11.11.11.1-1.12.32.7
Time in novel zone, NPP test1.92.06.3-0.8-1.0-1.11.11.1-1.3-1.31.31.31.3-1.32.22.5
Total zone transitions, NPP test2.63.76.9-1.5-1.5-2.32.32.3-2.0-1.62.01.51.4-1.42.62.2
Total locomotion distance, NPP test0.91.21.9-1.0-1.1-1.41.41.4-1.2-1.20.91.10.6-0.61.40.8
Locomotion velocity, NPP test1.01.42.7-1.0-1.1-1.41.41.4-1.3-1.20.81.20.5-0.51.71.1
Intraocular pressure0.91.32.3-1.3-1.2-0.90.90.9-1.1-1.51.11.31.4-1.40.90.4
Delta distance traveled before/after self-admin0.20.20.5-0.0-0.2-0.20.20.2-0.10.6-0.6-0.4-0.60.60.60.7
Delta ambulatory time before/after self-admin0.60.71.8-1.0-1.1-1.11.11.1-1.0-0.00.10.20.1-0.11.30.8
Parametrial fat weight0.40.91.7-1.3-1.3-1.21.11.0-1.2-0.90.70.90.5-0.51.10.2
Pavlov. Cond. lever latency4.15.18.6-2.5-2.3-2.12.12.1-2.3-2.22.72.22.9-2.91.60.3
Pavlov. Cond. magazine entry latency7.49.513.63.03.13.1-3.0-3.03.13.2-3.6-3.2-3.73.7-2.5-0.6
Pavlov. Cond. change in total contacts1.81.94.31.21.01.3-1.2-1.21.31.0-2.1-1.0-2.02.0-1.0-0.7
Pavlov. Cond. index score6.48.012.42.72.72.8-2.7-2.72.82.8-3.4-2.8-3.53.5-2.3-0.9
Pavlov. Cond. latency score6.17.712.62.82.72.7-2.6-2.62.72.8-3.4-2.7-3.53.5-2.1-0.6
Pavlov. Cond. lever contacts2.52.95.11.91.71.6-1.5-1.51.71.7-2.0-1.7-2.32.3-1.1-0.1
Pavlov. Cond. magazine entry number7.29.111.7-3.0-3.1-3.13.13.1-3.1-3.13.43.13.4-3.42.60.8
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.7-0.8-0.70.70.7-0.7-0.70.70.70.8-0.80.50.1
Pavlov. Cond. lever-magazine prob. diff.5.87.211.32.52.52.6-2.6-2.62.72.7-3.3-2.6-3.43.4-2.3-1.1
Pavlov. Cond. response bias6.47.910.72.82.92.8-2.8-2.82.92.9-3.1-2.9-3.33.3-2.5-0.9
Pavlov. Cond. lever latency0.60.91.41.11.11.2-1.2-1.21.11.0-0.5-1.0-0.20.2-1.0-0.1
Pavlov. Cond. magazine entry latency0.10.20.60.50.40.1-0.1-0.10.20.3-0.6-0.4-0.80.80.00.1
Pavlov. Cond. change in total contacts1.93.14.7-2.2-2.1-2.12.12.1-2.0-2.01.01.91.0-1.01.5-0.3
Pavlov. Cond. index score0.20.30.6-0.6-0.5-0.80.80.8-0.6-0.50.00.5-0.20.20.6-0.1
Pavlov. Cond. latency score0.10.20.4-0.4-0.4-0.60.60.6-0.5-0.4-0.10.3-0.30.30.5-0.0
Pavlov. Cond. lever contacts0.81.21.7-1.2-1.2-1.31.31.3-1.3-1.20.61.20.4-0.41.30.4
Pavlov. Cond. magazine entry number0.20.20.8-0.4-0.4-0.20.20.2-0.2-0.30.80.40.9-0.9-0.0-0.2
Pavlov. Cond. intertrial magazine entries0.50.71.10.70.71.0-1.0-1.00.90.7-1.0-0.8-0.70.7-1.0-0.6
Pavlov. Cond. lever-magazine prob. diff.0.20.20.5-0.5-0.4-0.70.70.7-0.6-0.40.00.4-0.20.20.5-0.0
Pavlov. Cond. response bias0.20.20.4-0.5-0.4-0.60.60.6-0.5-0.4-0.20.4-0.40.40.50.0
Time in closed arm before self-admin1.11.32.5-1.2-1.1-1.61.41.5-1.2-0.91.30.91.2-1.20.7-0.3
Time in closed arm after self-admin0.10.10.30.40.40.00.0-0.00.30.10.40.00.4-0.4-0.6-0.4
Time in open arm before self-admin0.70.81.71.11.11.3-1.1-1.31.10.9-0.3-0.6-0.20.2-0.90.3
Time in open arm after self-admin0.80.93.30.70.60.5-0.7-0.60.40.8-1.3-0.9-1.21.20.81.8
Bone: periosteal estimation0.10.10.3-0.4-0.5-0.10.10.1-0.3-0.20.50.30.5-0.50.0-0.5
Bone: periosteal perimeter0.61.11.71.21.11.3-1.3-1.31.21.2-0.5-1.2-0.60.6-0.9-0.2
Bone: post-yield work0.20.20.9-0.1-0.1-0.10.10.1-0.2-0.11.00.10.9-0.90.30.6
Progressive ratio test 1 active lever presses0.10.11.00.0-0.0-0.30.00.2-0.20.20.20.10.1-0.10.61.0
Progressive ratio test 1 breakpoint0.10.11.20.10.0-0.2-0.00.2-0.20.20.20.10.1-0.10.61.1
Progressive ratio test 1 inactive lever presses0.40.61.80.30.60.4-0.7-0.60.70.9-0.5-1.0-0.60.6-1.3-1.3
Progressive ratio test 2 active lever presses1.82.12.71.41.61.4-1.4-1.31.51.6-1.4-1.5-1.51.5-1.5-0.5
Progressive ratio test 2 breakpoint1.92.12.71.41.61.5-1.4-1.31.51.7-1.4-1.5-1.61.6-1.6-0.6
Progressive ratio test 2 inactive lever presses2.03.26.91.41.81.5-1.6-1.61.81.9-1.4-1.8-1.61.6-2.6-2.3
Incentive Sensitization - Responses2.02.85.01.51.71.8-1.6-1.61.81.7-1.5-1.6-1.61.6-2.2-1.4
Incentive Sensitization - Breakpoint2.22.95.11.51.71.8-1.6-1.61.81.7-1.6-1.6-1.61.6-2.3-1.5
Sum of active levers in priming session hrs 5-60.40.42.90.40.20.00.1-0.00.00.1-0.6-0.3-0.60.60.91.7
Progressive ratio2.53.95.0-1.8-1.9-2.12.22.1-2.1-2.02.12.12.0-2.02.11.1
Food seeking constrained by brief footshock0.70.81.61.21.31.0-1.0-0.91.10.8-0.6-0.8-0.60.6-1.0-0.1
Seeking ratio, punishment vs. effort3.75.47.32.42.52.6-2.7-2.62.62.3-2.0-2.3-1.91.9-2.7-1.1
Retroperitoneal fat weight1.25.06.8-2.6-2.6-2.62.42.6-2.5-2.31.92.41.8-1.82.10.2
Reaction time number correct0.10.30.70.60.70.4-0.5-0.50.60.5-0.0-0.80.0-0.0-0.7-0.2
Reaction time mean minus median0.00.10.6-0.10.00.10.0-0.1-0.20.20.4-0.10.2-0.20.40.8
Reaction time mean minus median AUC0.20.41.4-0.3-0.2-0.20.30.2-0.6-0.31.00.40.8-0.80.81.2
Reaction time num false alarms0.10.10.30.60.50.4-0.3-0.40.40.3-0.1-0.50.0-0.0-0.20.5
Reaction time num false alarms AUC0.10.10.70.40.30.2-0.1-0.10.10.00.3-0.20.5-0.50.20.8
Reaction time trials correct on left0.10.30.70.60.70.4-0.5-0.50.60.5-0.0-0.80.0-0.0-0.7-0.2
Reaction time trials on left0.10.30.70.60.70.5-0.5-0.50.60.5-0.0-0.80.0-0.0-0.8-0.2
Reaction time mean0.00.00.0-0.2-0.20.1-0.1-0.1-0.10.00.10.10.1-0.10.20.2
Reaction time mean AUC0.00.10.3-0.0-0.00.2-0.2-0.2-0.10.10.30.10.4-0.40.30.6
Median of all reaction times0.00.00.0-0.1-0.10.2-0.2-0.2-0.00.0-0.10.10.0-0.00.10.0
Reaction time omissions0.20.30.70.50.50.8-0.7-0.80.50.70.0-0.50.3-0.3-0.20.7
Reaction time false alarm rate0.00.00.30.30.10.1-0.0-0.10.0-0.10.00.10.2-0.20.30.6
Reaction time premature initiation rate1.11.52.9-1.7-1.7-1.21.21.1-1.4-1.21.21.01.1-1.11.40.3
Reaction time premature initiations0.40.81.5-1.2-1.2-0.90.80.8-1.0-0.81.10.41.0-1.00.80.1
Std. dev. reaction times0.20.31.4-0.3-0.2-0.20.20.1-0.5-0.20.60.30.5-0.50.91.2
Reaction time trials completed0.10.30.70.60.70.5-0.5-0.50.60.5-0.0-0.80.0-0.0-0.8-0.2
Reaction time trials AUC0.20.40.80.70.80.6-0.6-0.60.70.6-0.1-0.9-0.10.1-0.9-0.2
Run reversals in cocaine runway, females1.11.11.91.11.11.2-1.3-1.21.21.0-0.4-0.9-0.40.4-1.4-0.9
Run reversals in cocaine runway, males0.30.31.3-1.1-0.9-0.50.40.4-0.50.0-0.2-0.1-0.20.2-0.2-1.1
Latency to leave start box in cocaine runway0.10.10.3-0.6-0.4-0.30.30.2-0.3-0.0-0.4-0.2-0.50.50.1-0.3
Latency to leave start box in cocaine runway, F0.50.62.6-1.3-1.0-0.80.80.7-0.7-0.5-0.10.1-0.20.2-0.2-1.6
Latency to leave start box in cocaine runway, M0.90.81.51.21.10.9-1.0-1.00.90.9-0.8-0.8-0.80.8-0.10.9
Std. dev. time between licks in bursts2.53.46.81.72.02.0-2.0-2.02.01.9-1.0-1.9-1.11.1-2.6-1.8
Total sessions with >9 infusions0.40.51.40.60.80.9-0.8-0.80.80.80.1-0.7-0.10.1-1.2-0.6
Short access day 1 total inactive lever presses1.82.33.41.81.91.8-1.7-1.51.81.7-1.2-1.5-1.21.2-1.6-0.4
Short access day 10 total inactive lever presses0.20.43.4-0.5-0.3-0.2-0.10.2-0.1-0.20.50.20.5-0.5-1.0-1.8
Short access day 1 total infusions2.22.94.22.02.02.0-2.1-1.91.91.8-1.4-1.7-1.41.4-1.50.2
Short access day 10 total infusions1.11.42.71.61.51.5-1.4-1.41.41.2-0.7-1.0-0.80.8-1.00.2
Short access total infusions2.02.64.02.02.01.9-1.8-1.71.81.7-1.2-1.7-1.31.3-1.30.4
Short access day 1 locomotion0.40.51.00.80.91.0-0.6-1.00.90.5-0.0-0.9-0.10.1-0.80.2
Short access day 10 total locomotion0.20.31.5-0.0-0.2-0.20.30.1-0.3-0.30.60.40.5-0.50.81.2
Short access total locomotion0.20.21.80.40.30.3-0.0-0.20.10.10.2-0.30.0-0.00.31.3
One hour access (0.3 mA shock)0.30.30.70.70.70.4-0.7-0.40.40.7-0.1-0.6-0.30.3-0.10.8
Compulsive drug intake0.70.81.91.21.10.9-1.1-1.00.80.8-0.6-0.9-0.60.60.01.4
One hour access (shock baseline)0.20.30.70.30.50.3-0.5-0.30.50.7-0.5-0.6-0.60.6-0.8-0.7
Social response proportion0.10.10.3-0.5-0.5-0.20.10.2-0.3-0.20.40.10.6-0.60.30.2
Social responses0.40.51.1-0.5-0.6-0.50.60.6-0.7-0.70.70.50.8-0.81.01.0
Social time1.01.33.80.61.01.0-1.0-1.01.11.6-0.1-1.6-0.00.0-2.0-1.6
Soleus weight4.011.714.5-3.8-3.8-3.83.83.8-3.6-3.63.53.53.2-3.22.90.3
Bone: stiffness0.10.20.5-0.6-0.7-0.40.40.4-0.5-0.40.40.50.4-0.40.60.3
Tibialis anterior weight0.10.31.0-0.6-0.4-0.40.40.4-0.2-0.30.70.40.7-0.7-0.5-1.0
Time to tail flick, vehicle, before self-admin2.12.23.2-1.3-1.3-1.41.51.3-1.4-1.81.81.71.8-1.81.00.2
Time to tail flick, vehicle, after self-admin0.10.20.5-0.5-0.4-0.30.10.2-0.20.2-0.5-0.2-0.60.6-0.0-0.7
Time to tail flick, test, before self-admin0.40.53.40.50.40.6-0.5-0.60.20.10.5-0.10.5-0.50.61.8
Time to tail flick, test, after self-admin0.10.10.40.30.20.3-0.3-0.40.30.3-0.2-0.3-0.20.2-0.5-0.6
Delta time to tail flick, vehicle, before/after SA1.31.22.90.50.60.8-0.9-0.80.81.2-1.7-1.2-1.71.7-0.7-0.7
Delta time to tail flick, test, before/after SA0.10.10.90.20.1-0.20.20.20.1-0.1-0.40.0-0.40.4-0.4-0.9
Tibia length6.217.021.6-4.4-4.6-4.64.64.6-4.5-4.14.34.13.7-3.73.90.5
Ambulatory time before self-admin0.50.72.40.80.90.9-0.8-0.90.90.1-0.1-0.2-0.10.1-1.5-1.5
Ambulatory time after self-admin0.10.10.40.20.10.1-0.1-0.10.20.6-0.5-0.4-0.50.5-0.1-0.1
Bone: tissue strength2.82.95.1-2.2-2.3-1.91.91.9-1.8-1.91.11.91.1-1.11.0-1.1
Total heroin consumption1.61.84.4-2.1-1.9-1.51.61.5-1.4-1.10.81.10.7-0.70.4-1.5
Bone: trabecular number0.71.22.11.21.20.9-0.9-0.90.91.0-1.4-0.9-1.41.4-0.01.1
Bone: trabecular spacing1.51.92.7-1.6-1.6-1.31.31.3-1.3-1.41.61.31.6-1.60.4-1.1
Bone: trabecular thickness0.30.31.50.0-0.2-0.20.20.2-0.2-0.1-0.60.1-0.80.81.01.2
Bone: trabecular tissue density0.20.30.9-0.6-0.6-0.70.70.7-0.7-0.50.20.40.1-0.10.90.7
Water consumed over 24 hours0.20.31.6-0.4-0.3-0.20.20.2-0.1-0.10.60.10.6-0.6-0.7-1.3
Number of responses in last shaping day0.50.64.60.10.30.3-0.4-0.30.50.10.10.30.1-0.1-1.5-2.2