Hub : Genes

Trank1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr8_111341205_111344393 0.06 0.04 1.2e-07 0.06 0.05 0.06 0.06 5.0e-07 1.8e-06 4.0e-07 2.2e-07
2 Adipose gene expression Trank1 0.54 0.12 0.0e+00 0.45 0.48 0.48 0.48 1.6e-54 2.5e-60 6.1e-61 3.5e-60
3 Brain intron excision ratio chr8_111341205_111343161 0.02 0.01 8.8e-03 0.02 0.02 0.01 0.01 1.2e-02 3.4e-03 8.3e-02 1.8e-02
4 PL intron excision ratio chr8_111341205_111344393 0.02 0.01 9.8e-03 0.01 0.02 0.01 0.01 4.4e-02 4.8e-03 6.3e-02 4.0e-02
5 IL intron excision ratio chr8_111341205_111344393 0.13 0.09 6.2e-03 0.02 0.02 0.01 0.03 8.8e-02 1.1e-01 1.4e-01 6.6e-02
6 Liver gene expression Trank1 0.3 0.11 0.0e+00 0.29 0.32 0.32 0.32 2.0e-32 7.8e-37 4.2e-36 1.1e-36
7 Brain intron excision ratio chr8_111341205_111344393 0.06 0.04 6.0e-07 0.05 0.06 0.05 0.05 1.1e-05 4.9e-06 1.9e-05 2.4e-05
8 Adipose alternative TSS XM_039081614.1 0.04 0.02 5.8e-05 0.03 0.02 0.02 0.02 6.4e-04 2.2e-03 1.6e-03 1.7e-03
9 NAcc gene expression Trank1 0.04 0.03 1.5e-05 0.03 0.04 0.03 0.03 9.0e-05 1.9e-05 2.4e-04 1.2e-04
10 NAcc intron excision ratio chr8_111341205_111343161 0.02 0.02 2.7e-03 0.01 0.01 0.01 0.01 1.9e-02 9.7e-03 1.1e-02 1.8e-02
11 Brain gene expression Trank1 0.15 0.1 1.3e-05 0.06 0.05 0.06 0.06 1.7e-06 2.8e-05 4.1e-06 4.0e-06
12 Brain intron excision ratio chr8_111343445_111344393 0.03 0.02 3.4e-03 -0 0.01 0 0 7.6e-01 3.2e-02 3.1e-01 3.0e-01
13 Brain intron excision ratio chr8_111343246_111344393 0.02 0.02 7.4e-03 0.01 0.01 -0 0 1.8e-02 7.5e-02 3.6e-01 1.1e-01
14 Adipose isoform ratio XM_039081618.1 0.02 0.02 1.7e-03 0.04 0.02 0.01 0.03 8.4e-05 6.4e-03 1.0e-02 4.2e-04
15 LHb intron excision ratio chr8_111315727_111324306 0.27 0.14 8.3e-03 0 -0 0.05 0.06 2.7e-01 4.4e-01 2.7e-02 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.20.9-0.20.10.3-0.2-0.1-0.1-0.7-0.3-0.30.6-0.30.90.30.30.8
Area under the delay curve1.92.13.41.5-1.8-1.51.51.61.60.91.4-1.9-0.9-1.3-0.61.41.41.5
BMI with tail0.72.16.1-1.71.21.4-1.4-1.0-1.3-1.3-1.41.81.11.70.7-2.5-1.9-0.1
BMI without tail1.73.66.7-2.21.92.1-2.0-1.7-1.9-2.0-1.62.01.91.91.7-2.6-2.0-0.2
Body weight6.226.134.8-5.95.65.5-5.5-5.2-5.5-4.8-5.55.84.75.03.8-5.3-4.9-2.8
Weight adjusted by age0.40.51.5-0.70.70.5-0.5-0.5-0.7-0.0-0.71.00.10.8-0.3-0.8-1.0-1.2
Bone surface0.10.20.70.3-0.3-0.20.20.40.30.00.2-0.3-0.1-0.60.10.70.80.5
Bone volume0.10.10.60.1-0.2-0.00.00.20.1-0.30.0-0.30.1-0.50.40.60.80.6
Breakpoint value in progressive ratio session0.10.10.3-0.20.20.2-0.2-0.3-0.2-0.40.1-0.10.3-0.30.60.20.10.5
Number of licking bursts0.30.31.30.5-0.1-0.50.40.30.30.90.30.1-0.90.2-1.1-0.1-0.1-0.9
Context. condit. distance diff. score0.10.10.5-0.10.1-0.00.00.1-0.00.20.00.1-0.2-0.5-0.20.70.6-0.5
Locomotion velocity, session 10.10.10.40.2-0.3-0.20.20.20.3-0.00.7-0.4-0.0-0.20.20.30.50.6
Locomotion distance, session 10.91.13.3-1.20.81.2-1.2-0.9-0.9-1.7-0.60.51.50.21.8-0.4-0.21.0
Locomotion velocity, session 20.30.41.30.5-0.6-0.50.50.50.50.30.7-0.5-0.5-0.9-0.20.81.10.6
Locomotion distance, session 20.30.53.0-0.2-0.30.2-0.20.00.1-0.90.2-0.50.7-0.31.20.10.71.7
Locomotion velocity, session 30.30.41.8-0.4-0.10.4-0.40.0-0.2-1.0-0.0-0.10.8-0.11.2-0.10.11.3
Locomotion distance, session 31.31.43.40.9-1.4-0.80.81.21.00.11.0-1.3-0.3-1.70.21.41.81.8
Stereotopy head waving bouts, day 30.60.74.0-0.20.60.1-0.1-0.3-0.40.7-0.21.1-0.60.9-1.3-0.8-0.9-2.0
Stereotopy head waving duration, day 30.60.82.7-0.60.90.5-0.5-0.7-0.70.2-0.61.10.01.3-0.5-1.1-1.3-1.6
Locomotion velocity, session 70.50.62.3-0.60.30.7-0.7-0.6-0.5-1.2-0.5-0.11.20.11.5-0.1-0.01.0
Locomotion distance, session 70.70.92.20.7-1.1-0.70.70.80.90.10.7-1.2-0.2-1.20.31.21.41.5
Stereotopy head waving bouts, day 70.20.21.20.4-0.5-0.30.30.40.4-0.10.5-0.80.1-0.20.40.30.41.1
Stereotopy head waving duration, day 70.20.20.8-0.40.30.5-0.5-0.4-0.4-0.8-0.30.00.70.40.9-0.4-0.30.6
Locomotion velocity, session 80.40.41.4-0.70.20.7-0.6-0.3-0.5-1.0-0.30.30.8-0.71.20.50.70.7
Locomotion distance, session 80.60.93.4-0.80.20.8-0.7-0.4-0.4-1.6-0.3-0.11.3-0.41.80.20.71.7
Degree of sensitization distance1.21.32.1-1.11.31.1-1.1-1.4-1.1-0.8-1.11.00.91.40.7-1.2-1.4-0.9
Degree of sensitization stereotypy0.40.42.60.2-0.4-0.00.10.10.2-0.60.3-0.90.6-0.21.10.30.51.6
Conditioned locomotion2.63.04.32.0-2.1-1.91.92.01.91.51.8-2.1-1.5-1.6-1.21.71.51.2
Cocaine response after cond. corrected0.50.62.3-0.50.70.4-0.4-0.5-0.60.2-0.51.0-0.10.9-0.6-1.0-1.3-1.5
Cocaine response after cond. not corrected2.02.24.4-1.51.71.3-1.4-1.4-1.5-0.7-1.41.90.81.80.2-1.9-2.1-1.8
Cocaine response before conditioning1.01.21.9-1.31.21.3-1.3-1.1-1.2-1.4-1.01.01.20.91.3-1.1-0.70.1
Saline control response1.31.73.4-1.51.11.4-1.4-1.4-1.3-1.7-1.50.81.81.01.9-0.9-0.80.3
Bone: connectivity density0.30.51.40.7-0.7-0.50.50.60.70.00.4-1.1-0.0-0.80.30.90.51.2
Bone: cortical apparent density0.70.93.40.8-0.8-0.70.70.70.70.40.7-1.0-0.5-1.6-0.11.61.80.7
Bone: cortical area0.30.41.40.4-0.2-0.50.50.40.31.00.20.2-1.0-0.4-1.20.50.8-1.1
Bone: cortical porosity0.30.31.50.3-0.3-0.10.10.10.3-0.50.2-1.00.60.21.00.1-0.31.2
Bone: cortical porosity0.30.31.40.4-0.5-0.30.30.30.5-0.20.3-1.10.40.20.6-0.0-0.51.2
Bone: cortical thickness0.30.42.7-0.40.60.2-0.2-0.3-0.50.4-0.51.0-0.4-0.2-0.70.20.7-1.7
Bone: cortical thickness0.00.00.2-0.10.10.1-0.1-0.0-0.1-0.1-0.10.00.1-0.00.1-0.10.5-0.0
Bone: cortical tissue density0.71.03.40.8-0.8-0.70.70.70.70.40.7-1.0-0.5-1.6-0.11.61.90.7
Condit. Reinf. active minus inactive responses0.10.10.5-0.20.30.2-0.2-0.4-0.30.0-0.30.40.00.2-0.1-0.1-0.3-0.7
Condit. Reinf. active-inactive response ratio0.20.31.2-0.40.60.4-0.4-0.6-0.50.0-0.50.70.10.5-0.2-0.2-0.5-1.1
Condit. Reinf. active responses0.00.10.10.3-0.3-0.30.30.30.20.30.2-0.2-0.3-0.1-0.4-0.00.1-0.1
Condit. Reinf. inactive responses0.60.71.31.0-1.2-0.90.91.11.00.61.0-1.0-0.6-0.6-0.50.20.81.0
Incentive salience index mean0.00.10.10.3-0.3-0.20.20.30.30.30.2-0.2-0.2-0.3-0.30.20.20.1
Condit. Reinf. lever presses1.11.52.11.4-1.4-1.31.31.41.41.01.3-1.4-1.0-1.2-0.80.81.11.2
Condit. Reinf. active minus inactive responses1.62.03.4-1.91.61.6-1.6-1.7-1.7-1.4-1.61.71.30.41.2-0.5-0.4-1.2
Condit. Reinf. active-inactive response ratio1.51.62.6-1.51.41.3-1.3-1.3-1.3-1.0-1.31.60.91.30.6-1.5-1.3-1.1
Condit. Reinf. active responses1.21.73.0-1.71.51.5-1.5-1.6-1.5-1.1-1.51.71.10.30.9-0.2-0.1-1.4
Condit. Reinf. inactive responses0.30.41.90.2-0.2-0.20.20.00.10.30.2-0.1-0.4-1.1-0.21.41.4-0.4
Condit. Reinf. lever presses1.92.54.6-2.11.81.9-1.8-1.9-1.8-1.7-1.81.81.60.81.5-0.7-0.4-1.1
Condit. Reinf. lever reinforcers received1.52.13.6-1.91.71.7-1.6-1.8-1.7-1.3-1.71.81.30.51.1-0.5-0.4-1.4
Conditioned reinforcement - actives0.10.10.60.1-0.2-0.20.20.40.30.10.6-0.4-0.1-0.8-0.10.30.40.3
Conditioned reinforcement - inactives1.01.13.30.8-0.6-1.01.01.00.81.51.1-0.2-1.4-1.0-1.80.40.2-1.2
Conditioned locomotion0.30.31.70.3-0.6-0.40.40.50.6-0.10.7-0.90.1-0.60.30.20.31.3
Patch foraging indifference point 0 sec1.21.93.1-1.61.31.4-1.4-1.4-1.4-1.6-1.60.91.71.41.8-1.1-1.10.1
Patch foraging indifference point AUC0.40.52.1-0.4-0.10.3-0.3-0.2-0.1-1.0-0.2-0.60.9-0.81.40.80.81.0
Delay disc. indifference point, 0s delay0.10.10.4-0.4-0.1-0.00.00.20.1-0.1-0.2-0.10.20.50.1-0.4-0.60.2
Delay disc. indifference point, 16s delay1.11.11.81.4-1.2-1.01.01.11.10.61.0-1.3-0.7-0.9-0.41.11.21.1
Delay disc. indifference point, 2s delay0.20.30.40.4-0.6-0.60.60.60.60.40.6-0.7-0.4-0.5-0.30.60.30.5
Delay disc. indifference point, 24s delay1.01.01.41.1-1.1-0.91.01.01.10.61.2-1.2-0.7-1.0-0.41.11.10.8
Delay disc. indifference point, 4s delay2.12.22.91.4-1.7-1.51.61.61.61.21.5-1.7-1.2-1.5-1.01.61.71.0
Delay disc. indifference point, 8s delay1.71.83.01.6-1.7-1.41.41.61.60.91.3-1.7-0.9-1.1-0.61.21.21.4
Indifference point function ln k0.10.20.70.3-0.2-0.30.30.50.30.40.50.1-0.60.3-0.7-0.8-0.50.4
Indifference point function log k0.10.20.70.3-0.2-0.30.30.50.30.40.50.1-0.60.3-0.7-0.8-0.50.4
Patch foraging total patch changes 0 sec1.42.23.1-1.71.51.6-1.6-1.5-1.6-1.6-1.81.21.71.61.6-1.3-1.4-0.3
Patch foraging total patch changes 12 sec0.60.71.5-1.11.01.0-1.0-0.9-0.9-1.1-0.90.51.1-0.01.20.2-0.1-0.4
Patch foraging total patch changes 18 sec2.53.25.4-2.11.82.0-2.0-2.0-2.0-2.1-2.01.32.31.12.3-0.8-1.1-0.5
Patch foraging total patch changes 24 sec2.43.04.2-2.02.01.9-1.9-2.0-1.9-1.8-1.81.71.81.31.7-1.3-1.3-0.9
Patch foraging total patch changes 6 sec0.30.41.6-0.50.20.4-0.4-0.5-0.3-0.9-0.5-0.31.00.11.30.1-0.11.0
Patch foraging time to switch 0 sec0.30.41.30.9-0.3-0.60.60.50.51.00.7-0.2-1.0-0.1-1.10.3-0.0-0.5
Patch foraging water rate 0 sec0.20.30.7-0.80.60.6-0.6-0.7-0.7-0.4-0.80.70.50.00.4-0.1-0.2-0.6
Patch foraging water rate 12 sec0.30.50.9-0.70.80.7-0.7-0.9-0.7-0.6-0.60.80.50.80.4-1.0-0.8-0.3
Patch foraging water rate 18 sec0.60.73.8-0.50.50.3-0.3-0.4-0.30.1-0.60.9-0.11.3-0.6-1.9-1.6-0.7
Patch foraging water rate 24 sec0.70.91.7-1.20.90.9-0.9-0.9-1.0-0.7-1.11.10.70.80.5-1.2-1.3-0.7
Patch foraging water rate 6 sec0.20.40.8-0.50.60.7-0.7-0.7-0.7-0.8-0.50.50.7-0.00.9-0.2-0.20.4
Seeking ratio, delayed vs. immediate footshock1.51.73.31.4-1.8-1.51.51.61.71.00.8-1.7-0.8-1.0-0.70.80.51.6
Distance traveled before self-admin0.40.42.1-0.40.40.1-0.1-0.1-0.30.4-0.40.9-0.30.5-0.8-0.6-0.8-1.4
Distance traveled after self-admin0.50.61.40.9-0.4-0.60.60.40.50.81.2-0.3-0.9-0.8-0.81.01.0-0.3
Extensor digitorum longus weight0.10.61.60.7-0.6-0.80.80.80.71.10.7-0.3-1.1-0.4-1.30.40.7-0.4
Bone: elastic displacement0.20.22.1-0.30.50.2-0.2-0.3-0.30.3-0.20.6-0.3-0.1-0.50.00.1-1.4
Bone: elastic work0.50.72.0-1.01.10.8-0.8-0.7-1.0-0.4-0.81.30.30.20.2-0.5-0.1-1.4
Bone: endosteal estimation0.20.40.9-0.50.40.5-0.5-0.6-0.5-0.6-0.60.30.70.90.6-0.6-0.9-0.1
Bone: endosteal perimeter0.71.52.61.6-1.5-1.41.41.41.51.31.4-1.3-1.3-0.6-1.20.60.50.7
Epididymis fat weight0.41.02.5-1.10.70.9-0.9-0.7-0.8-0.9-1.10.81.01.40.8-1.2-1.6-0.3
Delta time in closed arm before/after self-admin0.10.10.50.2-0.4-0.20.30.30.30.0-0.2-0.4-0.00.30.0-0.2-0.30.7
Delta time in open arm before/after self-admin0.30.30.7-0.20.40.4-0.4-0.5-0.4-0.60.30.00.4-0.70.80.60.90.1
Diff in mean of infusions in LGA sessions0.30.31.60.20.2-0.30.20.10.00.80.30.4-0.8-0.1-1.10.1-0.0-1.3
Delay discount exponential model param2.32.43.7-1.71.91.6-1.6-1.7-1.7-1.1-1.61.91.11.50.8-1.6-1.6-1.4
Extinction: sum of active levers before priming0.40.40.8-0.60.10.4-0.4-0.2-0.2-0.7-0.8-0.00.90.80.8-0.9-0.90.6
Active lever presses in extinction session 60.80.81.6-0.80.50.8-0.7-0.6-0.6-1.0-1.20.41.11.21.0-1.1-1.20.6
Bone: final force0.71.12.2-1.21.31.1-1.1-1.2-1.2-0.6-1.21.50.61.10.3-1.1-0.6-1.3
Bone: final moment1.01.63.1-1.41.51.2-1.3-1.4-1.4-0.7-1.41.70.71.30.4-1.3-0.9-1.5
Food consumed during 24 hour testing period1.82.25.3-1.51.51.4-1.4-1.4-1.4-1.1-1.31.61.12.30.7-2.2-1.7-1.0
Glucose0.30.51.9-0.60.40.7-0.7-0.6-0.4-1.2-0.5-0.01.10.41.4-0.4-0.20.8
Heart weight1.82.65.0-1.72.11.6-1.6-1.9-1.8-0.9-1.82.20.91.60.4-1.3-1.4-1.9
Delay discount hyperbolic model param2.32.43.7-1.61.91.6-1.6-1.7-1.7-1.1-1.61.91.11.50.7-1.6-1.6-1.5
Intermittent access intake day 1-15 change0.90.82.60.7-0.4-0.70.70.80.51.30.60.1-1.3-0.9-1.60.60.8-1.4
Intermittent access intake escalation0.60.61.90.5-0.3-0.60.60.60.41.10.50.1-1.0-0.9-1.40.50.8-1.3
Intermittent access intake escalation 20.50.53.7-0.00.60.1-0.1-0.1-0.30.70.10.9-0.7-0.2-1.1-0.00.3-1.9
Intermitt. access day 1 inactive lever presses0.00.00.2-0.10.1-0.00.0-0.10.00.00.10.0-0.00.2-0.1-0.4-0.5-0.0
Intermitt. access day 15 inactive lever presses0.91.03.01.0-0.6-1.11.00.80.81.50.9-0.3-1.5-0.4-1.70.40.6-0.8
Intermitt. access escalation Index0.30.21.00.1-0.10.2-0.2-0.2-0.0-0.6-0.6-0.30.60.70.8-0.3-0.21.0
Intermittent access day 1 total infusions0.00.00.1-0.1-0.00.0-0.0-0.00.0-0.1-0.1-0.10.20.10.2-0.2-0.10.4
Intermittent access day 15 total infusions0.10.20.40.3-0.3-0.30.30.50.30.50.2-0.1-0.4-0.5-0.60.20.5-0.4
Intermittent access terminal intake (last 3 days)0.00.00.10.1-0.1-0.10.10.20.10.20.00.0-0.1-0.2-0.3-0.2-0.0-0.2
Intermittent access total infusions0.10.10.20.3-0.4-0.40.40.50.40.40.1-0.3-0.3-0.5-0.40.10.10.1
Intermittent access day 1 locomotion0.10.10.60.3-0.2-0.30.30.20.40.10.6-0.5-0.1-0.40.00.20.20.8
Intermittent access day 15 total locomotion0.30.41.10.7-0.7-0.60.60.70.70.20.7-0.9-0.2-0.6-0.00.10.21.0
Intermittent access total locomotion0.70.81.90.8-1.1-0.90.91.01.10.40.9-1.3-0.4-0.9-0.20.40.51.4
Intermittent access standard deviation0.70.75.3-0.41.00.3-0.4-0.5-0.60.50.11.2-0.6-0.4-1.00.00.3-2.3
Left kidney weight0.72.15.6-1.30.91.4-1.4-1.0-0.9-2.2-1.10.52.01.02.4-1.4-0.91.8
Right kidney weight0.31.03.1-0.70.20.8-0.7-0.3-0.4-1.5-0.7-0.01.40.81.7-0.8-0.61.8
Cocaine induced anxiety0.50.61.50.9-0.7-0.90.90.90.81.10.9-0.5-1.0-0.3-1.20.30.5-0.3
Post-drug Anxiety0.30.40.80.7-0.5-0.70.70.70.70.80.6-0.4-0.80.0-0.90.10.4-0.0
Baseline Anxiety0.10.10.30.5-0.4-0.40.40.40.40.30.1-0.5-0.3-0.2-0.20.30.50.5
Tail length5.316.123.0-4.84.64.5-4.5-4.5-4.5-4.2-4.24.04.13.23.9-3.2-3.0-2.1
Length with tail7.828.437.6-6.16.05.9-5.9-5.9-5.9-5.3-5.95.65.34.74.7-4.6-4.4-2.9
Length without tail5.912.918.3-4.13.93.8-3.8-3.8-3.9-3.3-4.33.93.43.52.8-3.2-3.2-2.3
Times rat made contact with spout0.40.51.2-0.60.70.6-0.6-0.7-0.6-0.4-0.50.70.41.10.2-0.9-0.8-0.6
Lifetime Intake0.10.10.20.2-0.4-0.30.40.40.40.20.2-0.4-0.2-0.5-0.20.00.10.3
Liver weight, left0.20.31.2-0.1-0.00.2-0.2-0.2-0.1-0.7-0.4-0.60.80.31.1-0.1-0.50.9
Liver weight, right1.22.03.3-1.61.11.5-1.4-1.2-1.3-1.8-1.40.91.81.51.8-1.5-1.40.4
Locomotor activity5.28.211.4-3.33.43.2-3.2-3.1-3.2-2.7-3.03.22.62.42.3-2.7-2.6-1.7
Locomotor testing distance5.28.612.2-3.33.53.2-3.2-3.1-3.3-2.8-2.73.12.72.92.3-3.0-3.1-1.4
Locomotor testing rearing0.40.61.0-0.71.00.7-0.8-0.8-0.9-0.5-0.70.90.50.90.3-0.8-0.9-0.6
Locomotion in novel chamber0.10.20.50.1-0.3-0.40.40.50.30.60.1-0.1-0.5-0.5-0.70.60.1-0.5
Locomotion in novel chamber post-restriction0.70.91.7-0.90.91.1-1.0-0.9-1.0-1.2-1.10.61.20.51.3-0.6-0.60.1
Fecal boli incidents, locomotor time 10.40.51.4-0.80.80.7-0.7-0.8-0.8-0.5-1.20.90.50.50.4-0.3-0.3-0.7
Change in fecal boli incidents, locomotor task0.10.10.4-0.60.00.2-0.20.0-0.2-0.4-0.10.00.40.30.4-0.3-0.60.3
Time >=10cm from walls, locomotor time 10.30.31.20.7-0.6-0.40.40.40.50.00.4-0.7-0.1-0.30.20.20.41.1
Bouts of movement, locomotor time 10.00.00.20.30.10.0-0.0-0.2-0.00.00.00.0-0.1-0.40.00.50.3-0.1
Total resting periods, locomotor time 10.00.00.10.30.20.1-0.1-0.2-0.1-0.0-0.10.10.0-0.20.00.30.1-0.1
Rest time, locomotor task time 10.20.30.50.6-0.7-0.60.60.70.70.40.2-0.7-0.3-0.0-0.40.1-0.10.7
Distance moved, locomotor task time 11.21.32.2-1.41.51.2-1.2-1.4-1.4-0.8-0.91.50.70.90.6-0.9-0.9-1.4
Vertical activity count, locomotor time 10.40.40.8-0.90.90.7-0.8-0.9-0.8-0.6-0.40.80.50.50.5-0.4-0.3-0.6
Time >=10cm from walls, locomotor time 21.41.52.1-1.51.31.3-1.3-1.5-1.3-1.2-1.41.21.21.21.1-1.1-1.0-0.4
Bouts of movement, locomotor time 20.20.20.6-0.40.30.2-0.2-0.2-0.40.1-0.60.6-0.00.4-0.2-0.5-0.4-0.8
Total resting periods, locomotor time 20.10.10.3-0.10.0-0.00.00.1-0.10.2-0.40.3-0.20.2-0.4-0.3-0.2-0.6
Rest time, locomotor task time 20.00.00.10.2-0.2-0.00.00.20.1-0.1-0.2-0.20.2-0.20.30.30.20.4
Distance moved, locomotor task time 20.70.81.6-1.01.20.8-0.8-1.2-0.9-0.5-0.61.10.40.90.2-1.0-1.0-1.0
Vertical activity count, locomotor time 20.10.10.3-0.00.40.1-0.1-0.6-0.1-0.10.10.2-0.00.3-0.0-0.3-0.2-0.2
Light reinforcement 10.61.12.2-1.21.11.0-1.0-1.1-1.0-1.1-0.80.91.01.21.0-1.5-1.4-0.1
Light reinforcement 20.30.43.50.2-0.7-0.30.30.50.6-0.40.2-0.80.30.20.6-0.7-0.41.9
Bone: marrow area0.20.40.9-0.60.50.6-0.6-0.7-0.6-0.6-0.60.30.71.00.7-0.7-0.9-0.0
Bone: maximum diameter0.40.81.70.9-0.7-0.90.90.80.81.20.8-0.4-1.2-0.8-1.30.80.7-0.4
Bone: maximum force0.71.11.6-1.21.21.1-1.1-1.2-1.2-0.8-1.21.30.81.20.6-1.0-0.7-1.1
Bone: maximum moment0.81.42.1-1.21.41.2-1.2-1.3-1.3-0.8-1.31.40.81.40.6-1.3-0.9-1.3
Mean time between licks in bursts0.91.31.91.2-1.0-1.21.21.11.11.31.2-0.8-1.3-1.2-1.41.21.0-0.1
Mean num. licks in bursts0.60.71.8-0.90.60.9-0.8-0.8-0.7-1.2-0.70.31.20.61.3-0.6-0.50.6
Cd content in liver2.32.54.3-1.71.91.5-1.6-1.8-1.8-0.9-1.81.81.11.70.7-1.1-1.7-2.1
Co content in liver0.10.10.7-0.10.20.1-0.1-0.2-0.30.2-0.20.5-0.20.1-0.4-0.10.1-0.9
Cu content in liver4.15.06.8-2.52.32.3-2.4-2.3-2.4-2.2-2.22.12.32.22.0-2.3-2.6-1.1
Fe content in liver1.31.54.1-1.41.41.2-1.3-1.6-1.5-0.7-1.61.40.90.70.6-0.1-0.6-2.0
K content in liver0.70.71.5-1.00.40.8-0.8-0.6-0.7-1.1-0.50.50.9-1.01.20.71.00.2
Mg content in liver0.60.63.7-0.2-0.40.1-0.00.20.1-0.40.2-0.20.1-1.70.61.41.90.6
Mn content in liver0.70.82.7-1.00.51.0-0.9-0.7-0.8-1.4-0.70.41.2-0.81.60.30.50.7
Na content in liver0.30.30.6-0.50.40.5-0.5-0.6-0.5-0.5-0.50.20.5-0.50.70.80.8-0.5
Rb content in liver1.21.56.2-1.01.40.9-1.0-1.4-1.3-0.1-1.41.50.41.3-0.1-0.7-1.2-2.5
Se content in liver0.20.31.6-0.1-0.2-0.00.00.10.1-0.10.1-0.0-0.1-1.20.11.01.10.1
Sr content in liver0.20.10.8-0.2-0.00.2-0.20.1-0.0-0.50.20.00.30.30.5-0.7-0.30.9
Zn content in liver4.65.06.4-2.52.32.4-2.4-2.3-2.4-2.4-2.32.02.42.12.3-2.2-2.2-0.7
Bone: minimum diameter0.20.30.70.7-0.6-0.70.70.60.70.80.6-0.4-0.80.0-0.8-0.10.20.1
Time in familiar zone, hab. session 11.21.12.51.1-0.8-1.11.10.90.91.50.9-0.6-1.4-0.8-1.61.20.6-0.9
Time in novel zone, hab. session 10.50.41.5-0.60.60.6-0.6-0.6-0.6-0.6-0.20.60.61.00.5-1.2-0.80.0
Total zone transitions, hab. session 10.81.22.8-1.10.61.1-1.0-0.8-0.8-1.6-0.50.41.50.81.7-1.2-0.81.3
Total locomotion distance, hab. session 10.30.40.9-0.60.40.6-0.6-0.5-0.5-0.9-0.30.30.80.31.0-0.6-0.40.7
Locomotion velocity, hab. session 10.30.51.7-0.70.30.7-0.7-0.5-0.5-1.1-0.40.11.0-0.01.3-0.3-0.11.0
Time in familiar zone, hab. session 20.80.82.30.6-0.5-0.70.70.50.51.00.6-0.2-1.1-1.3-1.11.31.5-0.8
Time in novel zone, hab. session 20.40.41.9-0.10.20.2-0.2-0.2-0.1-0.3-0.2-0.00.41.40.3-1.2-1.40.4
Total zone transitions, hab. session 20.20.31.4-0.40.20.4-0.4-0.2-0.2-0.80.00.00.60.20.8-0.6-0.21.2
Total locomotion distance, hab. session 20.30.41.2-0.60.40.6-0.6-0.5-0.4-1.0-0.40.20.8-0.11.1-0.2-0.10.8
Locomotion velocity, hab. session 20.30.31.3-0.50.20.5-0.5-0.4-0.3-1.0-0.2-0.00.8-0.51.10.10.31.0
Novel to familiar place preference ratio1.71.75.3-1.10.71.2-1.1-1.1-0.9-1.9-1.30.01.91.02.3-1.0-1.01.5
Novelty place preference1.71.85.5-1.00.71.2-1.1-1.1-0.8-1.9-1.2-0.02.01.02.3-1.0-1.01.6
Time in novel zone, NPP test1.91.95.0-1.20.91.3-1.3-1.2-1.0-1.9-1.40.22.01.32.2-1.3-1.31.3
Total zone transitions, NPP test2.53.67.3-2.11.52.1-2.0-1.5-1.6-2.7-1.31.22.41.42.7-2.0-1.31.4
Total locomotion distance, NPP test0.81.22.1-1.31.01.2-1.2-1.0-1.0-1.5-0.90.91.30.61.4-1.1-0.70.4
Locomotion velocity, NPP test0.91.32.9-1.40.91.3-1.3-1.0-1.1-1.7-0.90.81.50.41.7-0.9-0.40.7
Intraocular pressure1.11.53.0-1.21.31.2-1.2-1.4-1.2-1.0-1.51.01.21.41.0-1.1-1.7-0.8
Delta distance traveled before/after self-admin0.60.61.80.9-0.6-0.60.60.40.70.21.1-1.0-0.4-0.90.01.11.41.0
Delta ambulatory time before/after self-admin0.20.20.60.20.40.4-0.4-0.6-0.3-0.60.3-0.10.4-0.10.80.30.50.7
Parametrial fat weight0.91.72.6-1.11.41.3-1.4-1.3-1.3-1.5-0.91.01.41.51.4-1.6-1.50.2
Pavlov. Cond. lever latency4.86.19.3-2.72.82.5-2.5-2.7-2.6-2.1-2.52.42.23.01.7-2.5-2.7-1.8
Pavlov. Cond. magazine entry latency6.38.111.63.1-2.8-2.92.93.02.92.73.0-2.6-2.9-3.4-2.53.23.01.1
Pavlov. Cond. change in total contacts1.82.04.51.4-1.4-1.31.31.41.21.21.0-1.2-1.2-2.0-0.92.11.90.3
Pavlov. Cond. index score6.48.112.73.1-2.9-2.92.92.92.82.62.8-2.6-2.8-3.6-2.33.33.21.2
Pavlov. Cond. latency score6.27.912.73.0-2.9-2.82.82.92.82.52.8-2.7-2.6-3.6-2.13.33.31.5
Pavlov. Cond. lever contacts2.93.45.52.0-2.0-1.81.82.01.91.41.8-1.8-1.6-2.3-1.21.92.11.4
Pavlov. Cond. magazine entry number6.98.611.7-3.33.03.0-3.0-3.1-3.0-2.8-3.02.82.93.42.5-3.2-3.0-1.3
Pavlov. Cond. intertrial magazine entries0.40.40.6-0.80.60.7-0.7-0.6-0.7-0.6-0.60.60.70.70.6-0.7-0.6-0.4
Pavlov. Cond. lever-magazine prob. diff.5.87.211.32.9-2.6-2.72.72.72.62.62.7-2.3-2.8-3.4-2.43.13.00.8
Pavlov. Cond. response bias6.47.810.83.2-2.8-2.92.93.02.92.82.9-2.5-2.9-3.3-2.62.92.61.1
Pavlov. Cond. lever latency0.40.51.11.0-0.8-0.90.90.80.80.80.8-0.9-0.7-0.3-0.70.20.00.5
Pavlov. Cond. magazine entry latency0.10.20.70.2-0.3-0.20.20.40.30.10.4-0.1-0.3-0.8-0.10.60.80.0
Pavlov. Cond. change in total contacts2.02.84.8-2.22.01.9-1.9-1.9-1.9-1.7-1.82.01.50.91.4-0.7-0.6-1.4
Pavlov. Cond. index score0.10.10.3-0.60.40.4-0.4-0.3-0.4-0.4-0.20.60.2-0.20.20.20.5-0.5
Pavlov. Cond. latency score0.10.10.3-0.50.30.3-0.3-0.2-0.3-0.3-0.20.50.2-0.30.20.20.5-0.3
Pavlov. Cond. lever contacts0.91.22.0-1.41.21.3-1.3-1.2-1.2-1.3-1.11.11.20.71.2-0.7-0.4-0.3
Pavlov. Cond. magazine entry number0.30.41.1-0.40.50.4-0.5-0.6-0.5-0.4-0.60.40.51.00.3-0.9-1.00.1
Pavlov. Cond. intertrial magazine entries0.30.40.70.8-0.6-0.70.70.40.60.80.5-0.7-0.7-0.4-0.70.70.40.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.50.40.4-0.4-0.3-0.3-0.3-0.20.50.2-0.20.20.10.4-0.4
Pavlov. Cond. response bias0.10.10.3-0.50.30.4-0.4-0.3-0.3-0.5-0.20.40.3-0.20.40.30.5-0.3
Time in closed arm before self-admin1.41.62.4-1.31.51.5-1.5-1.3-1.5-1.1-1.01.61.21.10.8-1.2-1.0-1.1
Time in closed arm after self-admin0.10.10.5-0.10.20.2-0.2-0.1-0.2-0.1-0.30.30.20.6-0.0-0.7-0.6-0.1
Time in open arm before self-admin0.90.91.51.2-1.0-1.21.21.01.21.10.7-1.0-1.1-0.3-1.10.50.20.7
Time in open arm after self-admin0.80.92.70.7-0.7-0.40.40.40.6-0.31.0-1.30.2-1.30.81.41.21.6
Bone: periosteal estimation0.00.10.4-0.20.30.2-0.2-0.3-0.30.0-0.30.4-0.00.4-0.1-0.2-0.1-0.6
Bone: periosteal perimeter0.91.52.11.4-1.3-1.41.31.31.31.41.2-1.1-1.4-1.0-1.31.01.00.1
Bone: post-yield work0.10.20.7-0.20.30.3-0.3-0.3-0.2-0.3-0.30.20.30.80.2-0.8-0.70.1
Progressive ratio test 1 active lever presses0.10.10.6-0.1-0.00.2-0.2-0.1-0.0-0.5-0.3-0.30.6-0.10.7-0.3-0.40.8
Progressive ratio test 1 breakpoint0.10.10.70.1-0.10.1-0.10.10.1-0.4-0.3-0.40.5-0.00.6-0.4-0.50.8
Progressive ratio test 1 inactive lever presses0.50.51.30.6-0.3-0.70.60.50.51.01.0-0.2-1.0-0.8-1.10.50.5-0.6
Progressive ratio test 2 active lever presses0.60.61.00.9-0.8-0.80.90.90.90.80.8-0.8-0.7-1.0-0.70.70.80.4
Progressive ratio test 2 breakpoint0.50.50.70.9-0.7-0.80.80.80.80.80.6-0.7-0.7-0.8-0.70.60.60.2
Progressive ratio test 2 inactive lever presses1.82.04.81.3-1.0-1.51.41.41.22.01.6-0.7-1.9-1.4-2.21.01.2-0.7
Incentive Sensitization - Responses1.61.62.91.5-1.1-1.41.41.31.31.61.2-0.9-1.6-1.2-1.71.01.1-0.0
Incentive Sensitization - Breakpoint1.61.62.81.4-1.1-1.41.41.31.31.61.2-0.9-1.6-1.2-1.71.11.1-0.1
Sum of active levers in priming session hrs 5-60.40.30.8-0.80.60.6-0.6-0.7-0.5-0.8-0.40.30.80.40.9-0.3-0.30.2
Progressive ratio3.84.46.0-2.41.92.2-2.2-1.9-2.1-2.2-2.11.82.42.22.1-2.2-2.2-0.5
Food seeking constrained by brief footshock0.40.50.80.8-0.9-0.80.90.90.90.80.6-0.7-0.8-0.3-0.80.30.50.3
Seeking ratio, punishment vs. effort4.85.98.12.8-2.4-2.72.72.52.62.82.4-2.1-2.8-2.2-2.72.12.30.5
Retroperitoneal fat weight0.72.23.3-1.51.31.4-1.4-1.4-1.3-1.7-1.81.11.71.61.6-1.6-1.80.2
Reaction time number correct0.20.30.70.7-0.4-0.60.60.30.50.70.8-0.4-0.7-0.1-0.8-0.2-0.1-0.1
Reaction time mean minus median0.10.10.50.10.10.2-0.20.0-0.0-0.40.0-0.00.20.10.4-0.3-0.20.7
Reaction time mean minus median AUC0.20.30.6-0.40.40.5-0.5-0.3-0.3-0.7-0.50.20.70.60.8-0.8-0.70.5
Reaction time num false alarms0.20.30.60.6-0.6-0.60.60.40.60.40.6-0.8-0.4-0.5-0.20.50.80.5
Reaction time num false alarms AUC0.10.10.40.3-0.3-0.30.30.10.30.00.2-0.6-0.0-0.00.20.10.30.6
Reaction time trials correct on left0.20.30.70.7-0.4-0.60.60.30.50.70.8-0.4-0.7-0.1-0.8-0.2-0.1-0.1
Reaction time trials on left0.20.30.70.7-0.4-0.60.60.30.60.80.9-0.5-0.7-0.1-0.8-0.2-0.1-0.0
Reaction time mean0.00.00.10.10.20.1-0.1-0.0-0.1-0.1-0.00.10.10.10.1-0.0-0.30.0
Reaction time mean AUC0.00.00.30.10.10.1-0.10.1-0.0-0.1-0.1-0.10.10.30.2-0.3-0.50.3
Median of all reaction times0.00.00.10.10.30.1-0.1-0.1-0.1-0.0-0.10.1-0.00.10.00.1-0.3-0.2
Reaction time omissions0.30.41.01.0-0.4-0.80.70.50.60.90.7-0.7-0.80.2-0.80.40.2-0.4
Reaction time false alarm rate0.10.10.30.2-0.3-0.20.20.20.2-0.0-0.0-0.40.1-0.20.20.40.50.4
Reaction time premature initiation rate1.31.82.7-1.51.71.4-1.5-1.5-1.4-1.4-0.91.21.31.21.3-1.3-1.5-0.4
Reaction time premature initiations0.60.91.7-1.01.20.9-1.0-1.2-1.0-0.9-0.30.90.70.90.7-1.2-1.3-0.4
Std. dev. reaction times0.10.20.6-0.20.30.4-0.4-0.2-0.3-0.7-0.30.00.60.50.7-0.4-0.40.6
Reaction time trials completed0.20.30.70.7-0.4-0.60.60.30.60.80.9-0.5-0.7-0.1-0.8-0.2-0.1-0.0
Reaction time trials AUC0.30.40.80.8-0.5-0.70.70.40.60.80.9-0.5-0.8-0.2-0.9-0.1-0.0-0.0
Run reversals in cocaine runway, females1.71.62.41.5-1.4-1.51.51.51.41.51.2-1.1-1.5-0.8-1.50.70.80.3
Run reversals in cocaine runway, males0.30.21.0-0.10.80.3-0.4-0.7-0.50.10.40.6-0.3-0.2-0.20.10.6-1.0
Latency to leave start box in cocaine runway0.20.20.4-0.50.60.4-0.4-0.6-0.5-0.3-0.10.40.1-0.40.20.30.3-0.5
Latency to leave start box in cocaine runway, F0.91.03.6-1.11.50.9-1.0-1.3-1.2-0.3-0.51.50.20.1-0.0-0.2-0.2-1.9
Latency to leave start box in cocaine runway, M0.50.52.00.4-0.9-0.50.60.70.70.00.4-1.1-0.1-0.70.30.70.71.4
Std. dev. time between licks in bursts2.73.26.72.0-1.6-2.02.01.91.82.41.8-1.1-2.4-1.2-2.61.01.0-0.4
Total sessions with >9 infusions0.30.41.5-0.30.2-0.10.10.1-0.00.6-0.30.5-0.50.5-0.9-1.0-1.2-0.9
Short access day 1 total inactive lever presses1.92.13.21.4-1.6-1.71.71.81.61.81.5-1.3-1.7-1.3-1.80.90.90.2
Short access day 10 total inactive lever presses0.50.52.10.30.1-0.40.40.10.11.00.90.4-1.0-0.3-1.30.30.6-1.5
Short access day 1 total infusions0.50.50.90.6-0.8-0.90.90.90.90.90.6-0.7-0.8-0.8-0.90.30.10.2
Short access day 10 total infusions0.10.10.4-0.3-0.00.2-0.1-0.0-0.1-0.3-0.60.00.40.40.3-0.6-0.60.3
Short access total infusions0.20.20.50.4-0.6-0.50.50.60.60.20.3-0.7-0.2-0.4-0.2-0.1-0.10.7
Short access day 1 locomotion0.20.20.8-0.6-0.1-0.00.00.10.1-0.1-0.3-0.10.20.70.0-0.9-0.90.3
Short access day 10 total locomotion0.40.41.2-0.60.00.4-0.4-0.2-0.2-0.9-0.3-0.20.90.51.1-0.7-0.71.1
Short access total locomotion0.30.31.5-0.4-0.10.2-0.1-0.00.1-0.6-0.1-0.40.70.30.8-0.7-0.71.2
One hour access (0.3 mA shock)0.10.10.50.2-0.2-0.00.10.20.2-0.20.1-0.40.3-0.30.4-0.2-0.10.7
Compulsive drug intake0.20.21.50.1-0.3-0.00.10.10.2-0.4-0.2-0.50.40.30.7-0.1-0.11.2
One hour access (shock baseline)0.10.10.50.10.1-0.00.00.10.00.10.30.1-0.1-0.7-0.20.30.4-0.4
Social response proportion0.20.20.7-0.20.70.4-0.5-0.7-0.5-0.4-0.30.30.40.60.5-0.3-0.8-0.3
Social responses0.40.51.0-0.70.60.7-0.7-0.8-0.6-0.9-0.60.30.90.71.0-0.6-0.90.3
Social time1.11.44.71.4-0.5-1.21.10.90.91.81.5-0.2-1.9-0.4-2.20.1-0.0-0.9
Soleus weight3.410.013.6-3.73.43.4-3.4-3.4-3.4-3.1-3.43.43.03.12.6-3.3-2.5-1.5
Bone: stiffness0.10.20.3-0.40.40.4-0.4-0.5-0.4-0.4-0.50.30.50.50.5-0.2-0.1-0.2
Tibialis anterior weight0.00.10.4-0.30.30.2-0.2-0.1-0.20.1-0.30.6-0.10.4-0.3-0.5-0.1-0.7
Time to tail flick, vehicle, before self-admin2.22.23.4-1.81.41.5-1.5-1.3-1.5-1.3-1.81.51.41.81.0-1.8-1.7-0.8
Time to tail flick, vehicle, after self-admin0.30.41.8-0.40.90.5-0.5-0.8-0.7-0.1-0.00.80.0-0.3-0.10.20.1-1.3
Time to tail flick, test, before self-admin0.40.42.60.2-0.10.00.0-0.20.2-0.5-0.2-0.60.50.70.7-0.8-1.01.6
Time to tail flick, test, after self-admin0.10.10.40.0-0.1-0.30.30.30.20.50.2-0.0-0.4-0.2-0.60.2-0.1-0.5
Delta time to tail flick, vehicle, before/after SA1.21.12.71.1-0.5-0.90.90.60.71.11.3-0.5-1.3-1.6-1.11.61.3-0.5
Delta time to tail flick, test, before/after SA0.20.20.7-0.2-0.3-0.20.20.50.10.50.10.1-0.3-0.5-0.60.60.5-0.8
Tibia length6.117.223.3-4.84.44.5-4.5-4.2-4.4-4.4-4.34.34.24.03.8-4.2-3.7-1.3
Ambulatory time before self-admin0.30.31.4-0.10.0-0.10.10.2-0.10.6-0.20.6-0.40.3-1.0-0.3-0.6-1.2
Ambulatory time after self-admin0.10.10.40.6-0.2-0.20.20.10.20.10.6-0.3-0.2-0.4-0.10.60.60.4
Bone: tissue strength2.72.64.5-2.02.01.7-1.7-1.8-1.9-1.1-1.92.11.11.10.8-0.9-1.0-2.0
Total heroin consumption0.91.12.2-1.21.51.0-1.1-1.4-1.2-0.7-0.81.30.60.60.4-0.6-1.0-1.1
Bone: trabecular number0.71.12.21.0-1.1-0.80.81.01.00.20.8-1.3-0.3-1.40.11.41.31.5
Bone: trabecular spacing1.21.62.6-1.31.41.2-1.2-1.3-1.3-0.6-1.21.60.71.50.3-1.5-1.4-1.4
Bone: trabecular thickness0.20.31.2-0.1-0.10.2-0.20.0-0.0-0.7-0.1-0.40.6-0.71.00.60.61.1
Bone: trabecular tissue density0.20.20.8-0.50.40.5-0.5-0.6-0.4-0.8-0.30.10.70.20.9-0.10.10.6
Water consumed over 24 hours0.20.30.90.10.2-0.10.10.1-0.00.60.10.5-0.60.8-0.9-0.7-0.5-0.9
Number of responses in last shaping day0.50.51.60.5-0.6-0.80.80.70.61.10.3-0.2-1.0-0.6-1.20.60.6-0.6