Hub : Genes

Tpm2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tpm2 0.17 0.1 3.8e-10 0.1 0.04 0.1 0.08 3.7e-09 8.8e-05 1.6e-09 9.7e-08
2 IC isoform ratio NM_001024345.2 0.15 0.1 6.0e-03 0 -0 0 0 2.1e-01 5.0e-01 2.4e-01 3.2e-01
3 pVTA isoform ratio NM_001024345.2 0.04 0.03 1.5e-03 0.05 0.02 0.03 0.04 1.1e-04 1.6e-02 1.1e-03 5.5e-04
4 pVTA isoform ratio NM_001301235.1 0.04 0.03 2.5e-03 0.04 0.01 0.03 0.03 2.7e-04 4.0e-02 1.3e-03 1.2e-03
5 PL gene expression Tpm2 0.11 0.08 8.9e-09 0.08 0.07 0.08 0.08 5.1e-09 1.5e-08 2.3e-09 6.4e-09
6 pVTA alternative polyA NM_001301235.1 0.04 0.03 7.8e-03 0.04 0 0.05 0.03 5.0e-04 1.2e-01 1.3e-04 3.5e-03
7 IC gene expression Tpm2 0.2 0.13 3.9e-03 0.02 0.02 0 0.02 5.6e-02 4.0e-02 1.8e-01 5.7e-02
8 Adipose gene expression Tpm2 0.07 0.08 8.6e-03 0.01 0.02 0.01 0.01 4.3e-02 5.2e-03 1.5e-02 2.6e-02
9 IC isoform ratio NM_001301235.1 0.21 0.12 1.3e-03 0 -0 0 0 2.3e-01 4.2e-01 3.2e-01 2.0e-01
10 pVTA alternative polyA XM_008763680.2 0.04 0.03 8.3e-03 0.04 0 0.04 0.03 4.4e-04 1.3e-01 1.8e-04 2.4e-03
11 IC intron excision ratio chr5_62570861_62571383 0.32 0.17 1.2e-03 0.01 0.01 0.06 0.02 1.3e-01 1.3e-01 2.2e-03 6.2e-02
12 IC intron excision ratio chr5_62571228_62571383 0.31 0.17 1.5e-03 0.01 0.01 0.06 0.02 1.3e-01 1.3e-01 2.1e-03 6.4e-02
13 Liver gene expression Tpm2 0.08 0.05 3.3e-05 0.04 0.03 0.01 0.03 5.3e-05 5.4e-04 6.9e-02 2.4e-04
14 BLA gene expression Tpm2 0.33 0.2 2.7e-15 0.19 0.22 0.24 0.22 3.6e-10 1.0e-11 7.8e-13 1.1e-11
15 IC intron excision ratio chr5_62571899_62572044 0.32 0.16 7.9e-03 -0 -0 -0.01 -0.01 5.2e-01 3.9e-01 9.1e-01 7.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.12.91.5-1.4-1.41.41.70.80.3-0.00.2-0.70.2-0.30.81.5-0.7
Area under the delay curve0.40.41.2-0.90.80.7-0.7-1.1-0.10.0-0.40.10.1-1.01.0-0.7-0.70.3
BMI with tail0.93.18.12.2-2.5-2.32.32.71.61.1-1.01.2-1.50.3-0.50.42.8-0.8
BMI without tail1.44.29.02.6-3.0-2.72.73.02.11.6-0.71.7-1.91.2-1.50.22.60.3
Body weight2.310.118.23.7-4.3-4.14.13.83.53.4-2.33.4-3.31.2-1.4-1.33.61.4
Weight adjusted by age0.40.61.30.4-0.5-0.80.80.21.10.9-1.00.8-1.2-0.30.3-0.70.70.5
Bone surface0.50.91.81.2-1.2-1.31.31.31.00.8-0.50.7-0.90.1-0.2-0.01.2-0.0
Bone volume0.30.61.51.1-1.0-1.01.01.20.60.3-0.20.2-0.60.1-0.20.41.2-0.5
Breakpoint value in progressive ratio session1.82.28.4-1.20.10.1-0.1-1.50.31.8-2.51.9-0.1-1.41.4-2.9-0.51.8
Number of licking bursts2.03.27.62.5-2.5-2.32.32.81.71.1-0.11.0-1.61.4-1.50.52.30.1
Context. condit. distance diff. score0.10.20.5-0.40.40.4-0.4-0.2-0.5-0.50.1-0.50.6-0.40.40.40.3-0.7
Locomotion velocity, session 13.43.611.80.3-1.2-1.21.20.11.52.9-3.03.1-1.3-0.70.7-3.40.52.4
Locomotion distance, session 11.01.33.50.4-0.9-0.80.80.31.11.7-1.41.8-1.10.1-0.2-1.90.01.6
Locomotion velocity, session 21.21.43.31.7-1.5-1.71.71.81.40.50.10.4-1.50.7-0.70.60.9-0.3
Locomotion distance, session 22.33.25.91.8-2.1-1.81.81.71.92.1-0.42.1-2.01.8-2.0-1.30.22.4
Locomotion velocity, session 30.60.72.6-0.0-0.5-0.40.4-0.00.61.3-1.21.4-0.6-0.10.0-1.6-0.01.2
Locomotion distance, session 32.12.34.21.3-1.8-1.71.71.41.51.9-2.01.9-1.4-0.40.3-1.32.00.4
Stereotopy head waving bouts, day 30.50.63.0-0.2-0.0-0.10.1-0.50.11.1-0.81.1-0.10.3-0.3-1.6-0.51.7
Stereotopy head waving duration, day 30.20.21.0-0.40.40.3-0.3-0.7-0.30.3-0.20.30.40.3-0.3-0.8-0.41.0
Locomotion velocity, session 70.10.10.1-0.40.30.3-0.3-0.2-0.2-0.20.0-0.10.2-0.20.20.0-0.4-0.1
Locomotion distance, session 70.20.30.70.4-0.6-0.60.60.50.50.8-0.70.8-0.5-0.20.1-0.70.30.4
Stereotopy head waving bouts, day 71.21.32.81.1-1.3-1.41.41.01.11.4-1.41.3-0.9-0.30.2-0.91.70.5
Stereotopy head waving duration, day 70.60.71.10.9-1.0-1.01.00.80.81.0-0.50.9-0.80.6-0.6-0.60.80.8
Locomotion velocity, session 80.70.84.70.2-0.4-0.20.2-0.00.41.0-0.01.1-0.51.1-1.1-1.3-1.02.2
Locomotion distance, session 80.50.72.40.5-0.8-0.60.60.40.71.2-0.61.3-0.70.6-0.6-1.20.11.5
Degree of sensitization distance1.01.03.5-0.91.21.1-1.1-1.1-0.9-1.01.3-0.90.70.5-0.40.4-1.90.3
Degree of sensitization stereotypy1.01.13.31.1-1.2-1.31.31.21.01.0-1.20.8-0.9-0.50.4-0.21.8-0.3
Conditioned locomotion0.60.72.8-0.60.0-0.10.1-0.40.20.8-1.70.9-0.1-1.61.5-1.10.30.1
Cocaine response after cond. corrected1.11.33.2-1.61.11.2-1.2-1.7-0.80.3-1.10.50.9-1.01.0-1.8-0.80.7
Cocaine response after cond. not corrected1.01.13.9-1.30.91.0-1.0-1.5-0.60.6-0.80.70.6-0.20.3-2.0-1.21.5
Cocaine response before conditioning0.70.92.31.3-1.0-0.90.91.10.70.50.60.5-0.71.5-1.50.20.21.0
Saline control response1.01.32.90.9-1.4-1.01.00.90.91.7-1.11.6-0.80.8-0.8-1.70.41.6
Bone: connectivity density0.40.61.21.0-0.8-1.01.01.10.6-0.20.2-0.2-0.6-0.10.01.00.8-1.1
Bone: cortical apparent density0.50.72.70.20.10.2-0.20.5-0.5-1.21.4-1.10.40.7-0.71.6-0.2-1.0
Bone: cortical area1.42.15.82.1-1.9-1.61.62.41.10.10.90.0-1.11.5-1.71.41.4-0.4
Bone: cortical porosity0.20.20.4-0.40.60.4-0.4-0.6-0.3-0.40.3-0.50.3-0.30.40.2-0.5-0.1
Bone: cortical porosity0.10.10.4-0.00.1-0.10.1-0.20.10.1-0.30.0-0.0-0.60.6-0.20.2-0.1
Bone: cortical thickness0.71.14.01.1-0.9-0.60.61.60.2-0.81.1-0.8-0.20.6-0.92.01.3-1.5
Bone: cortical thickness0.50.61.4-0.50.50.8-0.8-0.1-1.1-1.11.0-0.91.0-0.0-0.11.2-0.2-0.7
Bone: cortical tissue density0.40.62.30.10.10.2-0.20.4-0.5-1.11.3-1.00.40.6-0.61.5-0.3-0.9
Condit. Reinf. active minus inactive responses0.30.40.90.9-0.7-0.80.80.80.50.20.40.2-0.60.7-0.60.40.00.3
Condit. Reinf. active-inactive response ratio0.50.61.1-0.80.91.0-1.0-0.7-1.0-0.80.6-0.81.0-0.20.20.5-0.7-0.3
Condit. Reinf. active responses1.72.25.12.3-1.8-2.02.02.11.50.80.40.7-1.61.4-1.30.60.80.6
Condit. Reinf. inactive responses2.43.06.42.5-2.1-2.22.22.41.80.70.80.6-1.82.1-2.10.91.00.6
Incentive salience index mean2.83.56.92.6-2.4-2.62.62.42.11.6-0.41.5-2.21.3-1.2-0.21.31.0
Condit. Reinf. lever presses7.410.418.94.1-4.1-4.44.43.83.83.3-1.53.2-3.71.8-1.8-1.22.51.9
Condit. Reinf. active minus inactive responses0.30.41.00.9-0.8-0.70.71.00.60.20.00.1-0.60.4-0.50.40.8-0.5
Condit. Reinf. active-inactive response ratio0.10.21.10.2-0.2-0.10.10.4-0.1-0.40.1-0.50.1-0.10.10.60.6-1.0
Condit. Reinf. active responses1.21.73.51.9-1.8-1.71.71.91.50.9-0.20.8-1.50.9-1.10.21.10.2
Condit. Reinf. inactive responses1.72.24.62.1-1.9-1.91.92.11.70.80.30.7-1.71.4-1.50.70.90.4
Condit. Reinf. lever presses1.62.25.02.2-1.7-1.71.72.21.50.11.0-0.1-1.61.7-1.81.40.7-0.4
Condit. Reinf. lever reinforcers received1.52.14.32.1-1.9-1.91.92.01.71.0-0.00.8-1.71.2-1.30.21.00.3
Conditioned reinforcement - actives0.50.83.1-0.30.3-0.50.5-0.51.00.3-1.20.2-1.0-1.71.7-0.6-0.0-0.8
Conditioned reinforcement - inactives0.50.74.0-0.90.60.3-0.3-0.9-0.10.0-1.00.10.2-2.01.9-0.6-0.3-0.4
Conditioned locomotion1.01.34.5-0.5-0.1-0.60.6-0.41.30.8-2.10.8-1.2-2.01.9-1.10.8-0.9
Patch foraging indifference point 0 sec1.83.312.10.1-0.8-1.21.2-0.11.32.3-3.52.3-1.1-2.42.2-2.61.50.5
Patch foraging indifference point AUC4.87.013.53.5-3.3-3.73.73.13.32.7-1.32.3-3.30.8-0.8-0.82.31.2
Delay disc. indifference point, 0s delay0.70.71.9-1.11.00.9-0.9-1.4-0.8-0.0-0.3-0.00.8-0.80.9-0.8-1.00.6
Delay disc. indifference point, 16s delay1.11.23.3-1.40.80.9-0.9-1.4-0.40.5-1.30.50.4-1.81.7-1.4-0.30.5
Delay disc. indifference point, 2s delay0.10.10.30.20.1-0.00.00.1-0.1-0.30.3-0.40.1-0.20.20.50.6-0.5
Delay disc. indifference point, 24s delay0.10.10.4-0.20.40.5-0.5-0.4-0.6-0.30.5-0.30.6-0.10.10.1-0.30.1
Delay disc. indifference point, 4s delay0.10.10.3-0.40.40.3-0.3-0.50.5-0.0-0.1-0.0-0.60.00.0-0.2-0.30.1
Delay disc. indifference point, 8s delay0.00.00.20.2-0.0-0.20.20.00.30.10.20.1-0.5-0.20.1-0.1-0.30.2
Indifference point function ln k1.42.44.5-2.12.02.1-2.1-2.0-1.9-1.30.3-1.11.9-1.11.10.2-1.1-0.5
Indifference point function log k1.42.44.5-2.12.02.1-2.1-2.0-1.9-1.30.3-1.11.9-1.11.10.2-1.1-0.5
Patch foraging total patch changes 0 sec1.83.511.90.4-1.2-1.51.50.31.52.4-3.42.4-1.3-2.22.0-2.51.90.4
Patch foraging total patch changes 12 sec1.41.84.61.5-1.5-1.81.81.51.41.2-1.41.0-1.3-0.70.7-0.22.1-0.5
Patch foraging total patch changes 18 sec0.60.92.01.1-1.0-1.31.30.81.41.1-0.70.9-1.40.1-0.1-0.70.70.6
Patch foraging total patch changes 24 sec1.62.85.01.7-1.7-2.22.21.42.21.9-1.91.6-2.2-0.60.5-1.01.80.3
Patch foraging total patch changes 6 sec2.94.48.21.7-2.1-2.62.61.42.52.6-2.92.4-2.3-1.11.0-1.92.30.6
Patch foraging time to switch 0 sec1.73.55.7-2.02.22.4-2.4-1.8-2.2-2.31.9-2.12.10.3-0.21.2-1.9-0.9
Patch foraging water rate 0 sec1.53.28.21.3-1.9-1.81.81.41.72.1-2.92.0-1.5-1.31.1-1.32.7-0.1
Patch foraging water rate 12 sec0.10.20.8-0.1-0.2-0.00.0-0.00.30.6-0.90.5-0.3-0.20.0-0.70.30.3
Patch foraging water rate 18 sec0.30.41.90.4-0.5-0.40.40.80.1-0.1-0.6-0.1-0.1-0.80.60.71.3-1.4
Patch foraging water rate 24 sec0.50.62.8-0.30.30.2-0.20.2-0.2-1.00.5-1.10.1-1.00.91.4-0.0-1.7
Patch foraging water rate 6 sec0.40.61.40.8-1.2-0.70.71.10.50.9-0.40.9-0.40.7-0.8-0.20.80.6
Seeking ratio, delayed vs. immediate footshock2.63.27.81.9-2.1-2.32.32.22.81.0-1.01.1-2.80.6-0.70.22.0-0.7
Distance traveled before self-admin4.15.411.92.0-2.7-2.52.52.23.42.3-1.12.4-3.42.2-2.2-1.21.01.9
Distance traveled after self-admin1.31.64.61.3-1.2-1.11.11.71.30.11.20.2-1.42.1-2.10.8-0.70.5
Extensor digitorum longus weight3.112.223.24.5-4.7-4.84.84.64.13.3-1.83.3-4.01.1-1.4-0.63.41.1
Bone: elastic displacement4.65.48.3-2.72.82.9-2.9-2.4-2.6-2.60.9-2.52.7-1.91.91.4-1.0-2.2
Bone: elastic work3.64.79.7-1.62.02.2-2.2-1.0-2.3-3.12.0-3.12.3-1.01.02.9-0.4-3.1
Bone: endosteal estimation1.02.23.41.8-1.8-1.81.81.41.51.8-0.71.6-1.51.2-1.1-1.10.81.7
Bone: endosteal perimeter1.12.33.91.6-1.8-1.81.81.41.62.0-1.21.8-1.50.7-0.7-1.41.01.5
Epididymis fat weight0.30.92.01.4-1.2-1.11.11.40.60.40.60.4-0.61.3-1.30.50.80.5
Delta time in closed arm before/after self-admin1.11.04.00.8-0.6-0.50.51.10.7-0.61.1-0.5-0.82.0-2.01.20.6-0.6
Delta time in open arm before/after self-admin0.50.52.0-0.70.50.3-0.3-0.9-0.20.3-0.60.30.1-1.11.1-0.9-1.40.4
Diff in mean of infusions in LGA sessions0.40.51.8-0.00.30.4-0.4-0.1-0.8-0.91.3-0.80.70.8-0.80.9-0.8-0.1
Delay discount exponential model param0.30.41.00.8-0.7-0.60.61.00.0-0.10.5-0.10.01.0-1.00.70.6-0.3
Extinction: sum of active levers before priming2.02.26.3-2.11.81.8-1.8-2.1-1.5-0.80.2-0.51.4-1.11.0-0.6-2.50.3
Active lever presses in extinction session 60.40.41.2-0.80.80.4-0.4-0.8-0.2-0.2-0.5-0.30.3-1.11.0-0.2-0.5-0.5
Bone: final force1.32.15.92.0-1.8-1.41.41.91.00.80.90.6-1.12.3-2.40.30.21.2
Bone: final moment1.11.85.81.8-1.5-1.21.21.80.80.51.20.3-0.92.3-2.40.60.11.0
Food consumed during 24 hour testing period0.60.91.51.1-1.2-0.90.91.10.81.1-0.21.1-0.90.8-1.0-0.60.31.2
Glucose1.82.95.32.2-2.2-2.32.32.11.91.6-1.01.6-1.80.6-0.7-0.42.00.5
Heart weight0.71.02.21.3-1.1-1.11.11.21.10.70.30.6-1.21.4-1.5-0.00.10.8
Delay discount hyperbolic model param0.30.30.90.6-0.5-0.40.40.8-0.2-0.20.5-0.20.20.9-0.90.70.5-0.3
Intermittent access intake day 1-15 change0.30.61.50.9-0.9-0.90.91.20.80.10.10.1-0.80.6-0.60.61.2-0.5
Intermittent access intake escalation0.30.61.50.9-0.8-0.80.81.20.7-0.10.4-0.1-0.70.9-0.80.81.0-0.5
Intermittent access intake escalation 20.81.02.31.1-0.9-0.70.71.50.6-0.60.8-0.5-0.61.1-1.01.51.1-1.3
Intermitt. access day 1 inactive lever presses0.31.02.81.2-1.7-1.31.31.50.61.2-0.71.3-0.50.1-0.2-0.51.00.7
Intermitt. access day 15 inactive lever presses0.10.20.70.2-0.5-0.30.30.40.80.5-0.40.5-0.90.2-0.2-0.40.10.5
Intermitt. access escalation Index0.60.92.00.9-1.1-1.11.10.80.61.0-0.21.0-0.30.9-1.0-0.61.41.1
Intermittent access day 1 total infusions1.62.58.6-1.91.50.8-0.8-2.2-0.30.2-2.20.30.4-2.92.9-1.6-0.5-0.8
Intermittent access day 15 total infusions0.30.51.7-0.20.2-0.40.4-0.20.6-0.0-1.0-0.0-0.6-1.21.2-0.10.8-1.3
Intermittent access terminal intake (last 3 days)0.50.72.3-0.20.1-0.50.5-0.20.30.2-1.40.3-0.2-1.51.5-0.41.0-1.2
Intermittent access total infusions1.01.24.4-0.40.2-0.60.6-0.50.70.5-2.00.5-0.6-2.12.0-0.90.9-1.1
Intermittent access day 1 locomotion1.92.49.2-1.81.40.7-0.7-2.0-0.20.1-2.00.20.3-3.03.0-1.3-0.7-1.0
Intermittent access day 15 total locomotion0.91.76.2-1.71.20.7-0.7-1.6-0.1-0.1-1.8-0.00.2-2.52.4-0.90.0-1.3
Intermittent access total locomotion1.82.27.1-1.81.61.0-1.0-1.7-0.5-0.9-1.1-0.80.6-2.72.6-0.2-0.4-2.0
Intermittent access standard deviation0.20.41.00.4-0.7-0.70.70.61.00.5-1.00.6-1.0-0.20.2-0.30.8-0.5
Left kidney weight0.62.95.11.6-2.0-1.81.81.41.92.2-0.92.2-1.81.3-1.4-1.60.52.3
Right kidney weight0.41.62.81.5-1.6-1.41.41.51.31.00.31.2-1.41.6-1.7-0.4-0.31.3
Cocaine induced anxiety0.10.20.8-0.40.40.6-0.6-0.4-0.8-0.20.4-0.30.90.1-0.00.1-0.20.3
Post-drug Anxiety0.60.72.80.9-0.8-0.70.70.50.41.00.10.8-0.41.1-1.1-0.60.11.7
Baseline Anxiety0.70.81.61.2-1.0-1.01.01.11.00.40.70.5-1.11.2-1.30.1-0.20.9
Tail length1.45.59.22.9-3.0-2.92.92.82.62.1-0.12.0-2.72.3-2.4-0.41.02.0
Length with tail1.46.19.82.5-3.0-3.03.02.22.93.1-1.83.1-2.81.1-1.3-2.01.32.4
Length without tail0.31.13.60.1-0.5-0.60.6-0.20.91.6-1.81.6-0.9-0.60.6-1.90.31.1
Times rat made contact with spout0.20.31.00.6-0.6-0.50.50.80.2-0.10.1-0.2-0.1-0.10.00.71.0-0.8
Lifetime Intake1.21.55.7-0.60.2-0.60.6-0.71.00.9-2.41.0-0.8-2.02.0-1.50.7-0.7
Liver weight, left0.10.21.00.0-0.00.1-0.1-0.1-0.20.20.40.30.20.8-0.8-0.4-0.61.0
Liver weight, right0.61.01.9-1.31.31.4-1.4-1.1-0.9-1.10.5-1.00.9-0.60.70.5-0.9-0.7
Locomotor activity0.00.00.20.1-0.1-0.20.20.1-0.10.10.20.20.0-0.10.1-0.1-0.40.4
Locomotor testing distance0.20.31.4-0.50.20.1-0.1-0.6-0.10.6-0.50.70.1-0.30.3-1.1-0.71.2
Locomotor testing rearing0.50.92.31.0-1.0-1.11.10.80.81.2-0.11.2-0.80.9-0.9-0.70.01.5
Locomotion in novel chamber0.50.62.1-0.60.90.7-0.7-0.5-0.4-1.20.7-1.10.4-0.40.40.9-0.2-1.5
Locomotion in novel chamber post-restriction1.01.63.91.6-0.9-1.01.01.60.9-0.51.5-0.6-1.02.0-1.91.60.6-0.6
Fecal boli incidents, locomotor time 10.60.81.5-0.91.20.9-0.9-0.9-0.9-1.20.7-1.10.8-0.60.70.7-0.7-0.9
Change in fecal boli incidents, locomotor task1.01.02.40.6-1.0-1.11.10.60.81.3-1.41.2-0.5-0.60.5-1.01.60.6
Time >=10cm from walls, locomotor time 10.50.51.6-0.0-0.5-0.30.3-0.10.21.1-1.31.1-0.1-0.60.5-1.20.60.9
Bouts of movement, locomotor time 11.21.32.6-1.41.61.4-1.4-1.5-1.2-1.10.7-1.11.1-0.70.90.3-1.3-0.3
Total resting periods, locomotor time 11.82.03.7-1.51.91.7-1.7-1.6-1.5-1.61.2-1.61.4-0.50.60.8-1.4-0.8
Rest time, locomotor task time 12.63.27.8-0.81.81.6-1.6-0.9-1.8-2.62.8-2.71.70.4-0.22.4-1.4-1.5
Distance moved, locomotor task time 12.03.06.51.1-2.0-1.71.71.21.72.5-2.42.6-1.60.0-0.2-2.11.51.5
Vertical activity count, locomotor time 11.23.07.30.8-1.6-1.31.30.61.52.6-2.22.7-1.40.7-0.8-2.60.92.4
Time >=10cm from walls, locomotor time 20.30.41.10.4-0.5-0.50.50.31.00.5-0.10.6-1.10.8-0.8-0.4-0.80.7
Bouts of movement, locomotor time 20.30.51.90.7-0.7-1.01.00.71.30.6-0.30.5-1.4-0.20.2-0.20.30.3
Total resting periods, locomotor time 20.10.20.70.3-0.3-0.60.60.30.80.3-0.30.2-0.8-0.60.6-0.00.2-0.1
Rest time, locomotor task time 21.01.23.0-1.01.41.3-1.3-1.1-1.6-1.10.6-1.21.7-0.70.90.7-0.4-0.7
Distance moved, locomotor task time 20.91.14.51.0-0.8-0.60.61.10.9-0.01.10.1-1.12.1-2.10.6-0.50.4
Vertical activity count, locomotor time 21.31.76.61.1-1.2-0.80.81.01.21.00.21.1-1.42.6-2.5-0.6-0.21.6
Light reinforcement 11.84.513.50.9-2.0-1.41.40.81.63.2-2.13.4-1.50.9-1.1-3.4-0.33.7
Light reinforcement 22.23.412.20.2-0.9-1.11.1-0.41.12.9-2.32.9-0.9-0.20.3-3.5-0.23.3
Bone: marrow area1.02.13.51.9-1.8-1.81.81.51.51.7-0.51.5-1.51.2-1.2-0.80.91.5
Bone: maximum diameter1.52.76.02.4-2.2-2.12.12.41.70.90.40.7-1.71.7-1.70.61.30.4
Bone: maximum force2.13.77.72.8-2.5-2.22.22.81.71.10.80.9-1.82.5-2.60.50.71.1
Bone: maximum moment1.73.06.42.5-2.2-1.91.92.51.40.81.10.6-1.52.4-2.50.70.60.9
Mean time between licks in bursts0.51.23.5-0.30.70.7-0.7-0.7-0.6-0.61.8-0.60.41.8-1.70.3-1.91.3
Mean num. licks in bursts1.11.83.3-1.71.81.7-1.7-1.8-1.3-1.10.5-1.11.2-1.11.20.2-1.5-0.5
Cd content in liver0.70.81.51.1-1.2-1.01.01.00.51.0-0.11.0-0.51.0-1.0-0.50.61.2
Co content in liver0.40.41.2-0.80.50.8-0.8-0.9-0.60.4-0.40.40.70.1-0.1-1.0-0.51.1
Cu content in liver1.31.52.5-1.31.51.6-1.6-1.3-1.5-1.21.3-1.11.40.5-0.40.5-1.50.2
Fe content in liver0.70.93.3-1.20.71.1-1.1-1.2-0.50.3-0.00.40.50.00.1-1.1-1.81.6
K content in liver0.20.20.8-0.50.20.3-0.3-0.7-0.10.4-0.50.40.2-0.10.2-0.9-0.40.6
Mg content in liver0.40.41.3-0.91.00.7-0.7-1.1-0.5-0.4-0.4-0.40.6-0.70.7-0.3-0.0-0.5
Mn content in liver0.80.81.81.3-1.0-1.01.01.30.8-0.10.7-0.1-0.81.2-1.20.80.7-0.3
Na content in liver1.61.83.6-1.01.21.6-1.6-1.1-1.4-1.01.7-0.81.21.6-1.50.3-1.91.1
Rb content in liver3.33.89.0-2.72.53.0-3.0-2.6-2.3-1.40.6-1.32.3-0.70.6-0.2-1.8-0.0
Se content in liver1.61.84.22.0-1.6-2.02.01.91.40.50.70.5-1.41.4-1.40.60.60.3
Sr content in liver0.70.61.81.0-0.6-1.31.30.51.30.6-0.10.5-1.30.5-0.4-0.30.10.5
Zn content in liver0.20.20.90.3-0.2-0.10.10.3-0.2-0.20.8-0.20.20.9-0.80.3-0.40.3
Bone: minimum diameter0.10.10.5-0.00.30.1-0.1-0.1-0.3-0.60.5-0.70.30.00.10.7-0.0-0.6
Time in familiar zone, hab. session 12.32.28.2-0.50.90.9-0.9-0.0-1.3-2.21.3-2.21.3-0.70.72.50.7-2.9
Time in novel zone, hab. session 11.91.98.4-1.10.80.9-0.9-1.6-0.11.0-0.41.1-0.10.6-0.4-2.3-2.42.9
Total zone transitions, hab. session 10.10.10.40.2-0.1-0.10.10.10.2-0.00.5-0.0-0.30.7-0.60.1-0.30.4
Total locomotion distance, hab. session 10.60.82.21.1-0.4-0.60.61.00.3-0.71.5-0.7-0.41.3-1.31.40.3-0.4
Locomotion velocity, hab. session 11.21.63.61.9-1.3-1.51.51.71.10.01.1-0.0-1.21.7-1.71.10.8-0.0
Time in familiar zone, hab. session 21.31.43.3-0.61.11.0-1.0-0.4-1.1-1.81.5-1.81.10.1-0.01.8-0.6-1.5
Time in novel zone, hab. session 21.01.13.1-1.30.80.9-0.9-1.5-0.40.7-1.20.80.5-0.90.9-1.8-0.81.1
Total zone transitions, hab. session 20.81.01.80.8-1.1-1.01.00.71.11.3-0.71.3-1.20.8-0.8-1.10.21.3
Total locomotion distance, hab. session 20.60.81.41.2-1.1-1.21.21.10.90.60.00.6-0.90.9-0.9-0.00.60.5
Locomotion velocity, hab. session 20.71.01.91.4-1.3-1.41.41.31.00.70.00.7-1.00.9-0.90.10.80.4
Novel to familiar place preference ratio1.92.05.4-2.11.81.8-1.8-2.3-1.1-0.1-0.7-0.11.2-1.21.3-1.3-1.40.6
Novelty place preference2.52.76.8-2.52.12.2-2.2-2.6-1.5-0.5-0.5-0.41.5-1.41.5-1.1-1.50.4
Time in novel zone, NPP test3.03.28.2-2.72.42.5-2.5-2.9-1.7-0.6-0.4-0.51.7-1.41.5-1.2-1.90.5
Total zone transitions, NPP test1.11.63.11.0-1.3-1.21.20.91.41.6-0.71.7-1.41.0-1.0-1.4-0.01.8
Total locomotion distance, NPP test1.82.53.91.6-1.9-2.02.01.51.81.9-1.31.9-1.70.5-0.5-1.31.21.2
Locomotion velocity, NPP test2.02.84.91.9-2.1-2.22.21.81.91.9-1.31.9-1.90.4-0.4-1.01.60.8
Intraocular pressure2.13.05.51.8-2.2-2.32.31.81.82.0-1.82.0-1.60.1-0.2-1.02.30.6
Delta distance traveled before/after self-admin0.50.61.6-0.10.40.6-0.6-0.0-1.3-0.81.3-0.81.30.1-0.10.8-0.9-0.0
Delta ambulatory time before/after self-admin1.11.43.4-0.61.11.2-1.2-0.6-1.8-1.21.7-1.31.8-0.00.10.9-1.5-0.1
Parametrial fat weight0.20.52.6-0.3-0.20.2-0.2-0.20.50.7-0.20.9-0.60.8-0.9-1.1-0.81.6
Pavlov. Cond. lever latency4.65.811.0-3.23.13.3-3.3-2.9-2.8-2.31.0-2.32.8-1.51.50.7-1.8-1.2
Pavlov. Cond. magazine entry latency0.50.71.31.1-0.9-1.01.00.90.90.40.50.4-1.01.1-1.10.1-0.20.6
Pavlov. Cond. change in total contacts1.92.03.81.8-1.8-2.02.01.71.71.5-0.81.4-1.70.7-0.7-0.50.90.7
Pavlov. Cond. index score2.32.95.62.4-2.1-2.32.32.12.01.30.11.2-2.11.7-1.7-0.00.70.9
Pavlov. Cond. latency score2.12.65.02.2-2.0-2.22.22.02.01.3-0.11.2-2.01.4-1.4-0.10.80.8
Pavlov. Cond. lever contacts4.14.99.63.0-2.9-3.13.12.82.62.0-0.82.0-2.61.3-1.4-0.41.70.9
Pavlov. Cond. magazine entry number0.50.61.3-1.11.01.0-1.0-1.1-0.9-0.3-0.4-0.30.9-0.90.9-0.4-0.2-0.2
Pavlov. Cond. intertrial magazine entries0.10.20.40.7-0.4-0.60.60.50.40.20.20.1-0.50.5-0.40.2-0.00.3
Pavlov. Cond. lever-magazine prob. diff.2.22.75.62.4-2.0-2.22.22.21.91.00.31.0-2.01.7-1.70.20.70.7
Pavlov. Cond. response bias2.83.46.32.5-2.4-2.52.52.42.11.6-0.21.5-2.21.6-1.6-0.20.91.0
Pavlov. Cond. lever latency1.62.24.9-2.21.71.8-1.8-2.1-1.5-0.2-1.0-0.01.6-1.71.7-1.2-0.60.0
Pavlov. Cond. magazine entry latency0.60.72.3-0.30.60.7-0.7-0.3-0.4-0.91.5-0.90.21.2-1.20.7-1.40.2
Pavlov. Cond. change in total contacts1.21.95.21.5-0.7-0.60.61.50.5-1.02.3-1.1-0.72.2-2.22.1-0.3-0.4
Pavlov. Cond. index score0.81.03.30.9-0.3-0.20.20.90.3-0.81.8-1.0-0.41.8-1.81.5-0.6-0.2
Pavlov. Cond. latency score0.81.02.90.9-0.4-0.30.31.00.3-0.91.7-1.0-0.51.6-1.51.6-0.3-0.5
Pavlov. Cond. lever contacts1.31.94.02.0-1.4-1.51.51.91.40.11.2-0.1-1.51.8-1.81.20.30.1
Pavlov. Cond. magazine entry number0.91.13.8-0.60.1-0.10.1-0.70.01.2-2.01.20.1-1.61.6-1.70.60.6
Pavlov. Cond. intertrial magazine entries0.30.51.80.5-0.6-0.70.70.50.50.7-1.00.6-0.3-0.60.5-0.41.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.91.23.80.9-0.3-0.20.20.90.2-0.92.0-1.1-0.31.9-1.91.6-0.6-0.3
Pavlov. Cond. response bias1.01.43.71.4-0.9-0.80.81.30.8-0.41.7-0.6-1.01.9-1.91.5-0.30.0
Time in closed arm before self-admin0.81.03.9-1.00.90.9-0.9-0.8-0.8-0.5-0.5-0.70.9-2.01.90.10.2-1.2
Time in closed arm after self-admin0.70.71.8-0.30.60.7-0.7-0.0-0.7-1.31.1-1.30.70.6-0.61.40.5-1.2
Time in open arm before self-admin1.31.42.31.2-1.4-1.41.40.91.11.5-0.71.5-1.00.9-0.9-1.10.61.5
Time in open arm after self-admin1.21.32.60.8-1.1-1.31.30.51.21.6-1.61.6-1.1-0.60.6-1.40.20.9
Bone: periosteal estimation1.12.44.92.2-2.1-1.91.92.21.41.20.21.0-1.51.7-1.80.11.10.9
Bone: periosteal perimeter0.40.71.41.0-1.2-1.01.01.00.91.1-0.61.0-0.80.5-0.5-0.60.60.7
Bone: post-yield work2.23.24.52.1-2.1-2.12.11.81.92.0-0.61.9-2.01.6-1.5-1.20.72.0
Progressive ratio test 1 active lever presses1.72.17.9-1.40.70.2-0.2-1.40.10.8-2.80.90.1-2.72.6-1.90.6-0.8
Progressive ratio test 1 breakpoint1.61.97.2-1.30.60.1-0.1-1.30.20.8-2.70.90.0-2.52.4-1.70.6-0.9
Progressive ratio test 1 inactive lever presses1.52.15.70.4-1.2-1.31.30.41.42.1-2.42.1-1.3-1.11.0-2.10.91.0
Progressive ratio test 2 active lever presses1.82.16.8-1.41.00.1-0.1-1.80.50.7-2.50.8-0.4-2.62.6-2.0-0.2-0.4
Progressive ratio test 2 breakpoint1.92.16.8-1.51.00.2-0.2-1.80.50.7-2.50.8-0.4-2.62.6-2.0-0.3-0.4
Progressive ratio test 2 inactive lever presses0.50.73.0-0.10.2-0.60.6-0.30.60.6-1.50.4-0.5-1.71.7-0.80.4-0.6
Incentive Sensitization - Responses0.40.51.4-0.90.60.2-0.2-1.00.30.4-1.00.4-0.3-1.21.2-1.0-0.50.2
Incentive Sensitization - Breakpoint0.40.61.6-0.90.70.3-0.3-1.00.30.3-1.10.3-0.3-1.31.2-1.0-0.40.2
Sum of active levers in priming session hrs 5-62.22.04.6-2.01.41.4-1.4-2.1-1.20.0-1.10.21.3-1.91.9-1.4-1.40.3
Progressive ratio0.00.10.2-0.10.0-0.10.1-0.20.20.2-0.10.2-0.2-0.40.3-0.4-0.40.2
Food seeking constrained by brief footshock6.88.313.72.7-3.4-3.63.62.63.73.4-3.03.3-3.5-0.30.0-2.12.81.4
Seeking ratio, punishment vs. effort1.31.93.21.6-1.7-1.81.81.51.61.5-1.21.4-1.50.2-0.3-0.61.80.5
Retroperitoneal fat weight0.31.42.3-1.01.21.4-1.4-0.9-1.3-1.51.5-1.31.21.0-1.01.1-0.9-0.3
Reaction time number correct0.10.31.00.1-0.4-0.40.40.10.40.8-1.00.9-0.4-0.50.3-0.8-0.00.3
Reaction time mean minus median0.81.96.81.1-0.2-0.30.31.2-0.1-1.72.5-1.6-0.11.6-1.72.6-0.1-1.2
Reaction time mean minus median AUC0.61.43.91.4-0.7-0.90.91.40.6-0.91.9-0.9-0.71.6-1.72.00.1-0.7
Reaction time num false alarms0.10.20.80.20.10.1-0.10.1-0.2-0.50.9-0.40.10.3-0.30.8-0.5-0.3
Reaction time num false alarms AUC0.10.20.40.7-0.6-0.60.60.70.50.30.10.4-0.50.2-0.20.10.00.1
Reaction time trials correct on left0.10.31.00.1-0.4-0.40.40.10.40.8-1.00.9-0.4-0.50.3-0.8-0.00.3
Reaction time trials on left0.10.20.80.0-0.3-0.30.30.00.30.7-0.90.8-0.3-0.50.4-0.8-0.10.3
Reaction time mean1.93.18.9-0.81.51.6-1.6-0.6-1.5-2.53.0-2.51.31.2-1.22.4-1.5-1.0
Reaction time mean AUC2.13.49.1-1.01.61.7-1.7-0.7-1.6-2.73.0-2.61.41.0-0.92.5-1.7-1.1
Median of all reaction times2.43.46.4-1.62.02.2-2.2-1.5-1.9-2.42.5-2.31.70.7-0.61.7-1.9-0.6
Reaction time omissions1.01.53.0-1.41.61.5-1.5-1.5-1.4-1.21.1-1.21.20.10.00.4-1.70.1
Reaction time false alarm rate0.10.20.70.00.30.2-0.2-0.0-0.2-0.60.8-0.60.20.2-0.10.7-0.3-0.4
Reaction time premature initiation rate2.02.84.8-1.81.82.1-2.1-1.3-2.0-2.10.6-1.92.1-1.01.01.2-0.0-2.2
Reaction time premature initiations1.01.73.3-1.61.41.7-1.7-1.1-1.6-1.5-0.0-1.21.6-1.21.10.7-0.0-1.8
Std. dev. reaction times1.22.28.70.30.50.5-0.50.4-0.7-2.03.0-2.00.41.7-1.62.7-1.0-0.8
Reaction time trials completed0.10.20.80.0-0.3-0.30.30.00.30.7-0.90.8-0.3-0.50.4-0.8-0.10.3
Reaction time trials AUC0.10.20.80.0-0.3-0.20.20.00.20.7-0.90.8-0.2-0.40.3-0.8-0.10.2
Run reversals in cocaine runway, females0.60.63.00.30.10.3-0.30.3-1.6-0.61.0-0.61.7-0.10.00.80.3-0.3
Run reversals in cocaine runway, males0.10.10.2-0.30.3-0.00.0-0.30.4-0.3-0.1-0.2-0.3-0.20.20.1-0.1-0.5
Latency to leave start box in cocaine runway0.40.41.10.8-1.0-0.80.81.10.80.3-0.10.3-0.70.3-0.30.30.9-0.2
Latency to leave start box in cocaine runway, F0.10.10.4-0.50.00.1-0.1-0.30.40.2-0.60.3-0.4-0.40.4-0.5-0.3-0.1
Latency to leave start box in cocaine runway, M1.61.53.01.6-1.7-1.51.51.71.41.0-0.31.0-1.20.7-0.8-0.11.50.6
Std. dev. time between licks in bursts0.30.31.3-0.60.80.6-0.6-0.7-0.5-0.60.7-0.60.40.1-0.00.3-1.10.1
Total sessions with >9 infusions1.11.45.0-0.6-0.1-0.50.5-0.71.01.3-2.21.4-0.9-1.61.6-1.9-0.10.2
Short access day 1 total inactive lever presses1.21.65.70.1-1.3-0.80.80.60.51.7-2.41.9-0.3-1.31.1-1.81.50.4
Short access day 10 total inactive lever presses0.30.61.91.0-1.3-0.90.91.40.70.4-0.10.5-0.70.5-0.60.31.20.1
Short access day 1 total infusions1.11.56.1-0.5-0.4-0.50.5-0.50.71.5-2.51.7-0.6-1.51.5-2.20.30.5
Short access day 10 total infusions1.01.35.2-0.70.1-0.30.3-0.90.51.2-2.31.3-0.4-1.71.6-2.00.30.3
Short access total infusions1.31.66.6-1.10.3-0.10.1-1.20.71.2-2.61.4-0.5-1.71.7-2.30.00.2
Short access day 1 locomotion1.11.33.2-1.81.00.8-0.8-1.6-0.20.1-1.50.50.3-1.61.6-1.6-1.2-0.5
Short access day 10 total locomotion0.61.12.0-1.31.41.0-1.0-1.1-0.4-1.20.3-1.10.4-1.01.00.5-1.3-1.4
Short access total locomotion0.70.82.6-1.10.60.2-0.2-1.00.20.4-1.40.5-0.0-1.61.6-1.2-0.7-0.2
One hour access (0.3 mA shock)1.01.13.40.00.1-0.90.9-0.61.31.1-1.80.9-1.2-1.41.3-1.30.7-0.0
Compulsive drug intake0.50.62.30.8-0.2-0.20.20.60.3-0.51.1-0.6-0.41.5-1.51.0-0.0-0.2
One hour access (shock baseline)1.32.07.7-0.50.0-0.90.9-0.81.51.5-2.81.5-1.3-1.81.9-2.10.70.1
Social response proportion2.32.65.6-1.11.51.8-1.8-1.1-1.9-1.82.4-1.71.91.6-1.51.2-1.70.1
Social responses0.71.02.71.2-1.2-1.01.01.20.70.50.50.7-0.71.6-1.60.00.20.8
Social time0.91.34.30.20.10.2-0.2-0.1-0.4-0.11.80.00.22.0-1.9-0.0-1.92.1
Soleus weight0.82.412.10.0-0.5-0.40.4-0.40.82.2-1.22.2-0.80.7-0.6-2.7-1.43.5
Bone: stiffness3.45.512.73.2-2.8-2.52.53.02.01.41.31.3-2.23.5-3.60.30.22.1
Tibialis anterior weight5.518.733.55.3-5.8-5.65.65.34.84.6-2.34.6-4.62.1-2.5-1.53.92.7
Time to tail flick, vehicle, before self-admin0.60.61.9-0.91.10.5-0.5-0.80.2-0.9-0.1-1.0-0.2-0.80.80.60.4-1.4
Time to tail flick, vehicle, after self-admin0.20.20.70.1-0.0-0.00.00.20.8-0.3-0.2-0.2-0.80.8-0.70.30.4-0.9
Time to tail flick, test, before self-admin0.30.31.20.6-0.3-0.70.70.30.50.4-0.40.2-0.4-0.70.6-0.01.1-0.0
Time to tail flick, test, after self-admin1.21.22.81.6-0.9-1.41.41.60.8-0.20.3-0.4-0.7-0.1-0.01.41.7-1.5
Delta time to tail flick, vehicle, before/after SA0.50.52.40.6-0.6-0.20.20.6-0.00.20.50.3-0.11.5-1.50.0-0.40.7
Delta time to tail flick, test, before/after SA0.30.31.50.1-0.00.2-0.20.4-0.2-0.90.6-0.70.20.3-0.31.0-0.2-1.2
Tibia length0.61.79.20.1-0.6-0.10.10.00.61.40.01.5-0.81.6-1.6-1.7-1.33.0
Ambulatory time before self-admin2.74.18.71.7-2.4-2.22.21.82.92.1-1.42.3-2.91.6-1.6-1.30.91.5
Ambulatory time after self-admin0.60.71.30.7-0.8-0.80.80.91.00.60.30.6-1.11.1-1.0-0.1-0.90.9
Bone: tissue strength1.21.25.80.8-0.4-0.20.20.50.3-0.11.5-0.1-0.52.4-2.30.3-1.01.3
Total heroin consumption1.11.33.1-1.50.80.9-0.9-1.6-0.50.6-1.50.80.6-1.41.3-1.8-1.10.7
Bone: trabecular number0.50.92.21.5-1.2-1.31.31.50.70.10.40.0-0.70.6-0.60.90.8-0.5
Bone: trabecular spacing0.10.10.4-0.00.00.2-0.20.2-0.3-0.50.5-0.40.30.1-0.10.60.2-0.5
Bone: trabecular thickness0.20.20.6-0.20.60.2-0.2-0.4-0.2-0.70.5-0.80.1-0.20.30.6-0.5-0.6
Bone: trabecular tissue density3.04.48.02.5-2.4-2.32.32.42.21.60.61.7-2.32.8-2.8-0.40.12.3
Water consumed over 24 hours0.40.52.20.9-1.0-0.80.81.10.40.4-0.50.4-0.4-0.20.00.31.5-0.6
Number of responses in last shaping day1.92.18.9-0.7-0.3-0.30.3-0.81.12.0-2.42.2-0.9-0.30.3-3.0-0.02.0