Hub : Genes

Tpm2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tpm2 0.17 0.1 3.8e-10 0.1 0.04 0.1 0.08 3.7e-09 8.8e-05 1.6e-09 9.1e-08
2 IC isoform ratio NM_001024345.2 0.15 0.1 6.0e-03 0 -0 0 0 2.1e-01 5.0e-01 2.4e-01 3.2e-01
3 pVTA isoform ratio NM_001024345.2 0.04 0.03 1.5e-03 0.05 0.02 0.03 0.04 1.1e-04 1.6e-02 9.5e-04 4.9e-04
4 pVTA isoform ratio NM_001301235.1 0.04 0.03 2.5e-03 0.04 0.01 0.03 0.03 2.7e-04 4.0e-02 1.6e-03 1.1e-03
5 PL gene expression Tpm2 0.11 0.08 8.9e-09 0.08 0.07 0.08 0.08 5.1e-09 1.5e-08 2.3e-09 5.1e-09
6 pVTA alternative polyA NM_001301235.1 0.04 0.03 7.8e-03 0.04 0 0.05 0.03 5.0e-04 1.2e-01 1.3e-04 3.2e-03
7 IC gene expression Tpm2 0.2 0.13 3.9e-03 0.02 0.02 0 0.02 5.6e-02 4.0e-02 1.8e-01 5.7e-02
8 Adipose gene expression Tpm2 0.07 0.08 8.6e-03 0.01 0.02 0.01 0.01 4.3e-02 5.2e-03 1.5e-02 2.5e-02
9 IC isoform ratio NM_001301235.1 0.21 0.12 1.3e-03 0 -0 0 0 2.3e-01 4.2e-01 3.2e-01 2.2e-01
10 pVTA alternative polyA XM_008763680.2 0.04 0.03 8.3e-03 0.04 0 0.04 0.03 4.4e-04 1.3e-01 1.8e-04 2.4e-03
11 IC intron excision ratio chr5_62571228_62571383 0.31 0.17 1.5e-03 0.01 0.01 0.06 0.02 1.3e-01 1.3e-01 2.1e-03 5.4e-02
12 IC intron excision ratio chr5_62570861_62571383 0.32 0.17 1.2e-03 0.01 0.01 0.06 0.02 1.3e-01 1.3e-01 2.2e-03 6.0e-02
13 Liver gene expression Tpm2 0.08 0.05 3.3e-05 0.04 0.03 0.01 0.03 5.3e-05 5.4e-04 6.7e-02 2.2e-04
14 BLA gene expression Tpm2 0.33 0.2 2.7e-15 0.19 0.22 0.24 0.22 3.6e-10 1.0e-11 8.4e-13 1.1e-11
15 IC intron excision ratio chr5_62571899_62572044 0.32 0.16 7.9e-03 -0 -0 -0.01 -0.01 5.2e-01 3.9e-01 9.1e-01 7.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.12.9-1.51.41.4-1.4-1.7-0.80.3-0.00.20.70.3-0.1-0.8-1.4-0.7
Area under the delay curve0.30.41.20.9-0.8-0.70.71.10.10.0-0.40.1-0.1-1.01.00.70.70.3
BMI with tail0.93.18.0-2.22.52.3-2.3-2.7-1.61.1-1.01.21.50.4-0.2-0.4-2.8-0.8
BMI without tail0.84.29.0-2.63.02.7-2.7-3.0-2.11.6-0.71.71.91.4-1.1-0.2-2.50.3
Body weight2.310.118.2-3.74.34.1-4.1-3.8-3.53.4-2.33.43.31.3-0.91.3-3.61.4
Weight adjusted by age0.20.61.3-0.40.50.8-0.8-0.2-1.10.9-1.00.81.2-0.30.30.7-0.70.5
Bone surface0.40.91.8-1.21.21.3-1.3-1.3-1.00.8-0.50.70.90.2-0.00.0-1.2-0.0
Bone volume0.30.61.5-1.11.01.0-1.0-1.2-0.60.3-0.20.20.60.2-0.1-0.4-1.2-0.5
Breakpoint value in progressive ratio session1.22.28.41.2-0.1-0.10.11.5-0.31.8-2.51.90.1-1.41.42.90.51.8
Number of licking bursts1.03.27.6-2.52.52.3-2.3-2.8-1.71.1-0.11.01.61.5-1.3-0.5-2.30.1
Context. condit. distance diff. score0.10.20.50.4-0.4-0.40.40.20.5-0.50.1-0.5-0.6-0.40.4-0.4-0.3-0.7
Locomotion velocity, session 13.23.611.8-0.31.21.2-1.2-0.1-1.52.9-3.03.11.3-0.70.73.4-0.52.4
Locomotion distance, session 11.01.33.5-0.40.90.8-0.8-0.3-1.11.7-1.41.81.10.2-0.11.9-0.01.6
Locomotion velocity, session 21.21.43.3-1.71.51.7-1.7-1.8-1.40.50.10.41.50.7-0.6-0.6-0.9-0.3
Locomotion distance, session 22.33.25.9-1.82.11.8-1.8-1.7-1.92.1-0.42.12.02.0-1.81.3-0.22.4
Locomotion velocity, session 30.60.72.60.00.50.4-0.40.0-0.61.3-1.21.40.6-0.00.11.6-0.01.2
Locomotion distance, session 32.02.34.2-1.31.81.7-1.7-1.4-1.51.9-2.01.91.4-0.30.61.3-2.00.4
Stereotopy head waving bouts, day 30.50.63.00.20.00.1-0.10.5-0.11.1-0.81.10.10.3-0.31.60.51.7
Stereotopy head waving duration, day 30.20.21.00.4-0.4-0.30.30.70.30.3-0.20.3-0.40.3-0.30.80.41.0
Locomotion velocity, session 70.10.10.10.4-0.3-0.30.30.20.2-0.20.0-0.1-0.2-0.20.2-0.00.4-0.1
Locomotion distance, session 70.20.30.7-0.40.60.6-0.6-0.5-0.50.8-0.70.80.5-0.10.20.7-0.30.4
Stereotopy head waving bouts, day 71.11.32.8-1.11.31.4-1.4-1.0-1.11.4-1.41.30.9-0.30.40.9-1.70.5
Stereotopy head waving duration, day 70.50.71.1-0.91.01.0-1.0-0.8-0.81.0-0.50.90.80.5-0.50.6-0.80.8
Locomotion velocity, session 80.70.84.7-0.20.40.2-0.20.0-0.41.0-0.01.10.51.1-1.11.31.02.2
Locomotion distance, session 80.50.72.4-0.50.80.6-0.6-0.4-0.71.2-0.61.30.70.7-0.61.2-0.01.5
Degree of sensitization distance0.91.03.50.9-1.2-1.11.11.10.9-1.01.3-0.9-0.70.4-0.6-0.41.90.3
Degree of sensitization stereotypy1.01.13.3-1.11.21.3-1.3-1.2-1.01.0-1.20.80.9-0.50.60.2-1.8-0.3
Conditioned locomotion0.60.72.80.6-0.00.1-0.10.4-0.20.8-1.70.90.1-1.51.61.1-0.30.1
Cocaine response after cond. corrected0.81.33.21.6-1.1-1.21.21.70.80.3-1.10.5-0.9-1.01.01.80.80.7
Cocaine response after cond. not corrected0.81.13.91.3-0.9-1.01.01.50.60.6-0.80.8-0.6-0.20.22.01.21.5
Cocaine response before conditioning0.70.92.3-1.31.00.9-0.9-1.1-0.70.50.60.50.71.5-1.5-0.2-0.21.0
Saline control response1.01.32.9-0.91.41.0-1.0-0.9-0.91.7-1.11.60.80.8-0.71.7-0.41.6
Bone: connectivity density0.30.61.2-1.00.81.0-1.0-1.1-0.6-0.20.2-0.20.6-0.10.2-1.0-0.7-1.1
Bone: cortical apparent density0.40.72.7-0.2-0.1-0.20.2-0.50.5-1.21.4-1.1-0.40.7-0.7-1.60.2-1.0
Bone: cortical area1.32.15.8-2.11.91.6-1.6-2.4-1.10.10.90.01.11.6-1.4-1.4-1.4-0.4
Bone: cortical porosity0.20.20.40.4-0.6-0.40.40.60.3-0.40.3-0.5-0.3-0.40.3-0.20.5-0.1
Bone: cortical porosity0.10.10.40.0-0.10.1-0.10.2-0.10.1-0.30.00.0-0.60.60.2-0.2-0.1
Bone: cortical thickness0.71.14.0-1.10.90.6-0.6-1.6-0.2-0.81.1-0.90.20.8-0.6-2.0-1.3-1.5
Bone: cortical thickness0.50.61.40.5-0.5-0.80.80.11.1-1.11.0-0.9-1.00.1-0.0-1.20.2-0.7
Bone: cortical tissue density0.40.62.3-0.1-0.1-0.20.2-0.40.5-1.11.3-1.0-0.40.6-0.6-1.50.3-0.9
Condit. Reinf. active minus inactive responses0.30.40.9-0.90.70.8-0.8-0.8-0.50.20.40.20.60.6-0.7-0.4-0.00.3
Condit. Reinf. active-inactive response ratio0.50.61.10.8-0.9-1.01.00.71.0-0.80.6-0.8-1.0-0.20.1-0.50.7-0.3
Condit. Reinf. active responses1.72.15.1-2.31.82.0-2.0-2.1-1.50.80.40.71.61.3-1.3-0.6-0.80.6
Condit. Reinf. inactive responses2.32.96.4-2.52.12.2-2.2-2.4-1.80.70.80.61.82.1-2.0-0.9-1.00.6
Incentive salience index mean2.73.56.9-2.62.42.6-2.6-2.4-2.11.6-0.41.52.21.2-1.20.2-1.31.0
Condit. Reinf. lever presses6.910.318.9-4.14.14.4-4.4-3.8-3.83.3-1.53.23.71.8-1.51.2-2.41.9
Condit. Reinf. active minus inactive responses0.20.41.0-0.90.80.7-0.7-1.0-0.60.20.00.10.60.4-0.3-0.4-0.8-0.5
Condit. Reinf. active-inactive response ratio0.10.21.1-0.20.20.1-0.1-0.40.1-0.40.1-0.5-0.1-0.10.2-0.6-0.6-1.0
Condit. Reinf. active responses1.21.73.5-1.91.81.7-1.7-1.9-1.50.9-0.20.81.51.0-0.8-0.2-1.10.2
Condit. Reinf. inactive responses1.42.14.6-2.11.91.9-1.9-2.1-1.70.80.30.71.71.5-1.3-0.7-0.90.4
Condit. Reinf. lever presses1.52.25.0-2.21.71.7-1.7-2.2-1.50.11.0-0.11.61.7-1.6-1.4-0.7-0.4
Condit. Reinf. lever reinforcers received1.42.04.3-2.11.91.9-1.9-2.0-1.71.0-0.00.81.71.3-1.1-0.2-0.90.3
Conditioned reinforcement - actives0.20.83.20.3-0.30.5-0.50.5-1.00.3-1.20.21.0-1.71.80.60.0-0.8
Conditioned reinforcement - inactives0.30.84.00.9-0.6-0.30.30.90.10.0-1.00.1-0.2-1.92.00.60.3-0.4
Conditioned locomotion0.91.44.50.50.10.6-0.60.4-1.30.8-2.10.81.2-1.92.11.1-0.8-0.9
Patch foraging indifference point 0 sec1.23.312.1-0.10.81.2-1.20.1-1.32.3-3.52.31.1-2.22.52.6-1.60.5
Patch foraging indifference point AUC2.96.913.5-3.53.33.7-3.7-3.1-3.32.7-1.32.33.30.7-0.60.8-2.31.2
Delay disc. indifference point, 0s delay0.60.71.91.1-1.0-0.90.91.40.8-0.0-0.3-0.0-0.8-0.80.70.81.00.6
Delay disc. indifference point, 16s delay0.81.23.31.4-0.8-0.90.91.40.40.5-1.30.5-0.4-1.81.81.40.30.5
Delay disc. indifference point, 2s delay0.10.10.3-0.2-0.10.0-0.0-0.10.1-0.30.3-0.4-0.1-0.20.2-0.5-0.6-0.5
Delay disc. indifference point, 24s delay0.10.10.40.2-0.4-0.50.50.40.6-0.30.5-0.3-0.6-0.10.1-0.10.30.1
Delay disc. indifference point, 4s delay0.10.10.30.4-0.4-0.30.30.5-0.5-0.0-0.1-0.00.6-0.0-0.00.20.30.1
Delay disc. indifference point, 8s delay0.00.00.2-0.20.00.2-0.2-0.0-0.30.10.20.10.5-0.20.20.10.40.2
Indifference point function ln k0.82.34.52.1-2.0-2.12.12.01.9-1.30.3-1.1-1.9-1.01.0-0.21.1-0.5
Indifference point function log k0.82.34.52.1-2.0-2.12.12.01.9-1.30.3-1.1-1.9-1.01.0-0.21.1-0.5
Patch foraging total patch changes 0 sec1.23.511.9-0.41.21.5-1.5-0.3-1.52.4-3.42.41.3-2.02.42.5-1.90.4
Patch foraging total patch changes 12 sec1.41.84.6-1.51.51.8-1.8-1.5-1.41.2-1.40.91.3-0.70.90.2-2.1-0.5
Patch foraging total patch changes 18 sec0.40.92.0-1.11.01.3-1.3-0.8-1.41.1-0.70.91.40.1-0.00.7-0.70.6
Patch foraging total patch changes 24 sec0.82.85.0-1.71.72.2-2.2-1.4-2.21.9-1.91.62.2-0.60.71.0-1.80.3
Patch foraging total patch changes 6 sec2.64.48.2-1.72.12.6-2.6-1.4-2.52.6-2.92.42.3-1.11.31.9-2.30.6
Patch foraging time to switch 0 sec0.93.55.72.0-2.2-2.42.41.82.2-2.31.9-2.1-2.10.3-0.4-1.21.9-0.9
Patch foraging water rate 0 sec0.93.28.2-1.31.91.8-1.8-1.4-1.72.1-2.92.01.5-1.21.51.3-2.7-0.1
Patch foraging water rate 12 sec0.00.20.80.10.20.0-0.00.0-0.30.6-0.90.50.3-0.10.20.7-0.30.3
Patch foraging water rate 18 sec0.20.51.9-0.40.50.4-0.4-0.8-0.1-0.1-0.6-0.10.1-0.60.8-0.7-1.3-1.4
Patch foraging water rate 24 sec0.40.62.80.3-0.3-0.20.2-0.20.2-1.00.5-1.1-0.1-1.01.0-1.40.0-1.7
Patch foraging water rate 6 sec0.40.61.4-0.81.20.7-0.7-1.1-0.50.9-0.40.90.40.8-0.70.2-0.80.6
Seeking ratio, delayed vs. immediate footshock2.23.27.8-1.92.12.3-2.3-2.2-2.81.0-1.01.12.80.6-0.4-0.2-2.0-0.7
Distance traveled before self-admin2.45.311.9-2.02.72.5-2.5-2.2-3.42.3-1.12.43.42.2-2.11.2-1.01.9
Distance traveled after self-admin0.91.64.4-1.31.21.1-1.1-1.7-1.30.11.20.21.42.1-2.1-0.80.70.5
Extensor digitorum longus weight3.012.123.2-4.54.74.8-4.8-4.6-4.13.3-1.83.34.01.3-0.80.6-3.41.1
Bone: elastic displacement4.25.38.32.7-2.8-2.92.92.42.6-2.60.9-2.5-2.7-1.91.8-1.41.0-2.2
Bone: elastic work3.64.79.71.6-2.0-2.22.21.02.3-3.12.0-3.1-2.3-1.00.9-2.90.4-3.1
Bone: endosteal estimation0.92.23.4-1.81.81.8-1.8-1.4-1.51.8-0.71.61.51.1-1.11.1-0.81.7
Bone: endosteal perimeter0.92.23.9-1.61.81.8-1.8-1.4-1.62.0-1.21.81.50.7-0.61.4-1.01.5
Epididymis fat weight0.20.92.0-1.41.21.1-1.1-1.4-0.60.40.60.40.61.3-1.3-0.5-0.80.5
Delta time in closed arm before/after self-admin1.11.03.8-0.80.60.5-0.5-1.1-0.7-0.61.1-0.50.81.9-2.0-1.2-0.6-0.6
Delta time in open arm before/after self-admin0.40.52.00.7-0.5-0.30.30.90.20.3-0.60.3-0.1-1.01.10.91.40.4
Diff in mean of infusions in LGA sessions0.30.51.80.0-0.3-0.40.40.10.8-0.91.3-0.8-0.70.8-0.9-0.90.8-0.1
Delay discount exponential model param0.30.41.0-0.80.70.6-0.6-1.0-0.0-0.10.5-0.1-0.01.0-1.0-0.7-0.6-0.3
Extinction: sum of active levers before priming1.42.16.22.1-1.8-1.81.82.11.5-0.80.2-0.5-1.4-1.01.00.62.50.3
Active lever presses in extinction session 60.40.41.10.8-0.8-0.40.40.80.2-0.2-0.5-0.3-0.3-1.01.10.20.5-0.5
Bone: final force1.32.15.8-2.01.81.4-1.4-1.9-1.00.80.90.61.12.4-2.3-0.3-0.21.2
Bone: final moment1.11.85.7-1.81.51.2-1.2-1.8-0.80.51.20.30.92.4-2.3-0.6-0.11.0
Food consumed during 24 hour testing period0.40.91.5-1.11.20.9-0.9-1.1-0.81.1-0.21.10.91.0-0.80.6-0.31.2
Glucose1.82.95.3-2.22.22.3-2.3-2.1-1.91.6-1.01.61.80.6-0.40.4-2.00.5
Heart weight0.61.02.1-1.31.11.1-1.1-1.2-1.10.70.30.61.21.5-1.40.0-0.00.8
Delay discount hyperbolic model param0.20.30.8-0.60.50.4-0.4-0.80.2-0.20.5-0.2-0.20.9-0.9-0.7-0.5-0.3
Intermittent access intake day 1-15 change0.10.61.5-0.90.90.9-0.9-1.2-0.80.10.10.10.80.6-0.6-0.6-1.2-0.5
Intermittent access intake escalation0.10.61.5-0.90.80.8-0.8-1.2-0.7-0.10.4-0.10.70.8-0.9-0.8-0.9-0.5
Intermittent access intake escalation 20.60.92.3-1.10.90.7-0.7-1.5-0.6-0.60.8-0.50.61.0-1.0-1.5-1.1-1.3
Intermitt. access day 1 inactive lever presses0.11.02.8-1.21.71.3-1.3-1.5-0.61.2-0.71.30.50.20.00.5-1.00.7
Intermitt. access day 15 inactive lever presses0.00.20.7-0.20.50.3-0.3-0.4-0.80.5-0.40.50.90.2-0.20.4-0.10.5
Intermitt. access escalation Index0.30.92.0-0.91.11.1-1.1-0.8-0.61.0-0.21.00.30.9-0.90.6-1.41.1
Intermittent access day 1 total infusions0.82.58.61.9-1.5-0.80.82.20.30.2-2.20.3-0.4-2.92.91.60.5-0.8
Intermittent access day 15 total infusions0.20.51.70.2-0.20.4-0.40.2-0.6-0.0-1.0-0.00.6-1.21.20.1-0.8-1.3
Intermittent access terminal intake (last 3 days)0.40.72.50.2-0.10.5-0.50.2-0.30.2-1.40.30.2-1.51.60.4-1.0-1.2
Intermittent access total infusions1.01.24.70.4-0.20.6-0.60.5-0.70.5-2.00.50.6-2.12.20.9-0.9-1.1
Intermittent access day 1 locomotion1.32.49.31.8-1.4-0.70.72.00.20.1-2.00.2-0.3-3.03.11.30.6-1.0
Intermittent access day 15 total locomotion0.41.76.21.7-1.2-0.70.71.60.1-0.1-1.8-0.0-0.2-2.42.50.9-0.0-1.3
Intermittent access total locomotion1.82.27.11.8-1.6-1.01.01.70.5-0.9-1.1-0.8-0.6-2.62.70.20.4-2.0
Intermittent access standard deviation0.10.41.0-0.40.70.7-0.7-0.6-1.00.5-1.00.61.0-0.20.30.3-0.8-0.5
Left kidney weight0.42.95.1-1.62.01.8-1.8-1.4-1.92.2-0.92.21.81.4-1.21.6-0.52.3
Right kidney weight0.21.62.7-1.51.61.4-1.4-1.5-1.31.00.31.11.41.6-1.50.40.41.3
Cocaine induced anxiety0.10.20.80.4-0.4-0.60.60.40.8-0.20.4-0.3-0.90.1-0.1-0.10.20.3
Post-drug Anxiety0.60.72.8-0.90.80.7-0.7-0.5-0.41.00.10.80.41.1-1.10.6-0.11.7
Baseline Anxiety0.50.81.6-1.21.01.0-1.0-1.1-1.00.40.70.51.11.3-1.2-0.10.20.9
Tail length1.05.49.2-2.93.02.9-2.9-2.8-2.62.1-0.12.02.72.4-2.20.4-0.92.0
Length with tail1.46.09.8-2.53.03.0-3.0-2.2-2.93.1-1.83.12.81.3-1.02.0-1.32.4
Length without tail0.21.13.6-0.10.50.6-0.60.2-0.91.6-1.81.60.9-0.50.61.9-0.31.1
Times rat made contact with spout0.20.31.0-0.60.60.5-0.5-0.8-0.2-0.10.1-0.20.1-0.00.2-0.7-1.0-0.8
Lifetime Intake1.21.55.70.6-0.20.6-0.60.7-1.00.9-2.41.00.8-2.02.11.5-0.7-0.7
Liver weight, left0.10.21.0-0.00.0-0.10.10.10.20.20.40.3-0.20.8-0.90.40.61.0
Liver weight, right0.61.01.91.3-1.3-1.41.41.10.9-1.10.5-1.0-0.9-0.60.6-0.50.9-0.7
Locomotor activity0.00.00.2-0.10.10.2-0.2-0.10.10.10.20.2-0.0-0.10.10.10.40.4
Locomotor testing distance0.10.31.40.5-0.2-0.10.10.60.10.6-0.50.7-0.1-0.30.31.10.61.2
Locomotor testing rearing0.30.92.3-1.01.01.1-1.1-0.8-0.81.2-0.11.20.80.9-0.90.7-0.01.5
Locomotion in novel chamber0.50.62.10.6-0.9-0.70.70.50.4-1.20.7-1.1-0.4-0.40.4-0.90.2-1.5
Locomotion in novel chamber post-restriction0.51.63.8-1.60.91.0-1.0-1.6-0.9-0.51.5-0.61.01.9-2.0-1.6-0.6-0.6
Fecal boli incidents, locomotor time 10.30.81.50.9-1.2-0.90.90.90.9-1.20.7-1.1-0.8-0.70.6-0.70.7-0.9
Change in fecal boli incidents, locomotor task0.91.02.4-0.61.01.1-1.1-0.6-0.81.3-1.41.20.5-0.50.61.0-1.60.6
Time >=10cm from walls, locomotor time 10.40.51.60.00.50.3-0.30.1-0.21.1-1.31.10.1-0.50.61.2-0.60.9
Bouts of movement, locomotor time 11.01.32.61.4-1.6-1.41.41.51.2-1.10.7-1.1-1.1-0.80.6-0.31.2-0.3
Total resting periods, locomotor time 11.72.03.71.5-1.9-1.71.71.61.5-1.61.2-1.6-1.4-0.60.3-0.81.4-0.8
Rest time, locomotor task time 12.03.27.80.8-1.8-1.61.60.91.8-2.62.8-2.7-1.70.2-0.5-2.41.5-1.5
Distance moved, locomotor task time 11.13.06.5-1.12.01.7-1.7-1.2-1.72.5-2.42.61.60.20.12.1-1.51.5
Vertical activity count, locomotor time 10.43.07.4-0.81.61.3-1.3-0.6-1.52.6-2.22.71.40.8-0.72.6-0.92.4
Time >=10cm from walls, locomotor time 20.20.41.1-0.40.50.5-0.5-0.3-1.00.5-0.10.61.10.8-0.90.40.80.7
Bouts of movement, locomotor time 20.20.51.9-0.70.71.0-1.0-0.7-1.30.6-0.30.51.4-0.20.30.2-0.30.3
Total resting periods, locomotor time 20.10.20.7-0.30.30.6-0.6-0.3-0.80.3-0.30.20.8-0.60.70.0-0.1-0.1
Rest time, locomotor task time 20.71.23.01.0-1.4-1.31.31.11.6-1.10.6-1.2-1.7-0.80.7-0.70.4-0.7
Distance moved, locomotor task time 20.81.14.5-1.00.80.6-0.6-1.1-0.9-0.01.10.11.12.1-2.1-0.60.50.4
Vertical activity count, locomotor time 20.81.86.6-1.11.20.8-0.8-1.0-1.21.00.21.11.42.5-2.60.60.21.6
Light reinforcement 11.04.513.5-0.92.01.4-1.4-0.8-1.63.2-2.13.41.51.1-0.93.40.33.7
Light reinforcement 21.53.412.2-0.20.91.1-1.10.4-1.12.9-2.32.90.9-0.30.33.50.23.3
Bone: marrow area0.92.13.5-1.91.81.8-1.8-1.5-1.51.7-0.51.51.51.2-1.20.8-0.91.5
Bone: maximum diameter1.32.76.0-2.42.22.1-2.1-2.4-1.70.90.40.71.71.7-1.6-0.6-1.30.4
Bone: maximum force1.93.77.7-2.82.52.2-2.2-2.8-1.71.10.80.91.82.6-2.5-0.5-0.71.1
Bone: maximum moment1.52.96.4-2.52.21.9-1.9-2.5-1.40.81.10.61.52.5-2.3-0.7-0.50.9
Mean time between licks in bursts0.21.23.70.3-0.7-0.70.70.70.6-0.61.8-0.6-0.41.7-1.9-0.31.91.3
Mean num. licks in bursts0.61.73.31.7-1.8-1.71.71.81.3-1.10.5-1.1-1.2-1.11.0-0.21.5-0.5
Cd content in liver0.70.81.5-1.11.21.0-1.0-1.0-0.51.0-0.11.00.51.0-0.90.5-0.61.2
Co content in liver0.40.41.20.8-0.5-0.80.80.90.60.4-0.40.4-0.70.1-0.21.00.51.1
Cu content in liver1.31.52.51.3-1.5-1.61.61.31.5-1.21.3-1.1-1.40.5-0.6-0.51.50.2
Fe content in liver0.70.93.31.2-0.7-1.11.11.20.50.3-0.00.4-0.5-0.0-0.11.11.81.6
K content in liver0.20.20.80.5-0.2-0.30.30.70.10.4-0.50.4-0.2-0.10.10.90.40.6
Mg content in liver0.40.41.30.9-1.0-0.70.71.10.5-0.4-0.4-0.4-0.6-0.70.70.3-0.0-0.5
Mn content in liver0.70.81.8-1.31.01.0-1.0-1.3-0.8-0.10.7-0.10.81.2-1.1-0.8-0.7-0.3
Na content in liver1.61.83.61.0-1.2-1.61.61.11.4-1.01.7-0.8-1.21.6-1.8-0.31.91.1
Rb content in liver3.33.89.02.7-2.5-3.03.02.62.3-1.40.6-1.3-2.3-0.60.50.21.8-0.0
Se content in liver1.51.84.2-2.01.62.0-2.0-1.9-1.40.50.70.51.41.4-1.3-0.6-0.50.3
Sr content in liver0.70.61.8-1.00.61.3-1.3-0.5-1.30.6-0.10.51.30.4-0.50.3-0.10.5
Zn content in liver0.20.20.9-0.30.20.1-0.1-0.30.2-0.20.8-0.2-0.20.9-0.9-0.30.40.3
Bone: minimum diameter0.10.10.50.0-0.3-0.10.10.10.3-0.60.5-0.7-0.3-0.1-0.0-0.70.1-0.6
Time in familiar zone, hab. session 12.02.28.20.5-0.9-0.90.90.01.3-2.21.3-2.2-1.3-0.70.6-2.5-0.7-2.9
Time in novel zone, hab. session 11.71.98.41.1-0.8-0.90.91.70.11.0-0.41.10.10.5-0.62.32.42.9
Total zone transitions, hab. session 10.10.10.5-0.20.10.1-0.1-0.1-0.2-0.00.5-0.00.30.6-0.7-0.10.30.4
Total locomotion distance, hab. session 10.60.82.2-1.10.40.6-0.6-1.0-0.3-0.71.5-0.70.41.3-1.3-1.4-0.2-0.4
Locomotion velocity, hab. session 11.11.63.6-1.91.31.5-1.5-1.8-1.10.01.1-0.01.21.6-1.6-1.1-0.8-0.0
Time in familiar zone, hab. session 21.21.43.30.6-1.1-1.01.00.41.1-1.81.5-1.8-1.10.0-0.1-1.80.6-1.5
Time in novel zone, hab. session 21.01.13.11.3-0.8-0.90.91.50.40.7-1.20.8-0.5-0.90.91.80.81.1
Total zone transitions, hab. session 20.81.01.8-0.81.11.0-1.0-0.7-1.11.3-0.71.31.20.8-0.81.1-0.21.3
Total locomotion distance, hab. session 20.60.81.4-1.21.11.2-1.2-1.1-0.90.60.00.60.90.9-0.90.0-0.60.5
Locomotion velocity, hab. session 20.71.01.9-1.41.31.4-1.4-1.3-1.00.70.00.61.00.9-0.9-0.1-0.80.4
Novel to familiar place preference ratio1.52.05.42.1-1.8-1.81.82.31.1-0.1-0.7-0.1-1.2-1.31.11.31.40.6
Novelty place preference2.12.76.82.5-2.1-2.22.22.61.5-0.5-0.5-0.4-1.5-1.41.31.11.50.4
Time in novel zone, NPP test2.63.28.22.7-2.4-2.52.52.91.7-0.6-0.4-0.5-1.7-1.41.31.21.80.5
Total zone transitions, NPP test1.11.63.1-1.01.31.2-1.2-0.9-1.41.6-0.71.71.41.1-1.01.40.01.8
Total locomotion distance, NPP test1.82.43.9-1.61.92.0-2.0-1.5-1.81.9-1.31.91.70.5-0.41.3-1.21.2
Locomotion velocity, NPP test2.02.84.9-1.92.12.2-2.2-1.8-1.91.9-1.31.91.90.4-0.31.0-1.60.8
Intraocular pressure1.93.05.5-1.82.22.3-2.3-1.8-1.82.0-1.82.01.60.20.01.0-2.30.6
Delta distance traveled before/after self-admin0.50.61.60.1-0.4-0.60.60.01.3-0.81.3-0.8-1.30.1-0.2-0.81.0-0.0
Delta ambulatory time before/after self-admin0.81.43.40.6-1.1-1.21.20.61.8-1.21.7-1.3-1.8-0.0-0.1-0.91.5-0.1
Parametrial fat weight0.20.52.60.30.2-0.20.20.2-0.50.7-0.20.90.60.9-0.81.10.81.6
Pavlov. Cond. lever latency4.65.811.03.2-3.1-3.33.32.92.8-2.31.0-2.3-2.8-1.51.3-0.71.8-1.2
Pavlov. Cond. magazine entry latency0.50.71.2-1.10.91.0-1.0-0.9-0.90.40.50.41.01.1-1.1-0.10.30.6
Pavlov. Cond. change in total contacts1.92.03.8-1.81.82.0-2.0-1.7-1.71.5-0.81.41.70.7-0.60.5-0.90.7
Pavlov. Cond. index score2.32.95.6-2.42.12.3-2.3-2.1-2.01.30.11.22.11.6-1.60.0-0.70.9
Pavlov. Cond. latency score2.02.65.0-2.22.02.2-2.2-2.0-2.01.3-0.11.22.01.4-1.30.1-0.80.8
Pavlov. Cond. lever contacts4.14.99.6-3.02.93.1-3.1-2.8-2.62.0-0.82.02.61.3-1.20.4-1.70.9
Pavlov. Cond. magazine entry number0.50.61.31.1-1.0-1.01.01.10.9-0.3-0.4-0.3-0.9-0.90.90.40.2-0.2
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.70.40.6-0.6-0.5-0.40.20.20.10.50.4-0.5-0.20.00.3
Pavlov. Cond. lever-magazine prob. diff.2.22.75.6-2.42.02.2-2.2-2.2-1.91.00.31.02.01.7-1.6-0.2-0.70.7
Pavlov. Cond. response bias2.73.46.3-2.52.42.5-2.5-2.4-2.11.6-0.21.52.21.6-1.50.2-0.91.0
Pavlov. Cond. lever latency1.52.14.92.2-1.7-1.81.82.11.5-0.2-1.0-0.0-1.6-1.71.61.20.60.0
Pavlov. Cond. magazine entry latency0.50.72.30.3-0.6-0.70.70.30.4-0.91.5-0.9-0.21.2-1.3-0.71.40.2
Pavlov. Cond. change in total contacts0.81.95.2-1.50.70.6-0.6-1.5-0.5-1.02.3-1.20.72.2-2.2-2.10.4-0.4
Pavlov. Cond. index score0.71.13.3-0.90.30.2-0.2-0.9-0.3-0.81.8-1.00.41.7-1.8-1.50.6-0.2
Pavlov. Cond. latency score0.61.02.9-0.90.40.3-0.3-1.0-0.3-0.91.7-1.00.51.5-1.6-1.60.3-0.5
Pavlov. Cond. lever contacts1.21.84.0-2.01.41.5-1.5-1.9-1.40.11.2-0.11.51.8-1.8-1.2-0.20.1
Pavlov. Cond. magazine entry number0.81.13.80.6-0.10.1-0.10.7-0.01.2-2.01.3-0.1-1.61.61.7-0.60.6
Pavlov. Cond. intertrial magazine entries0.20.51.9-0.50.60.7-0.7-0.5-0.50.7-1.00.60.3-0.60.70.4-1.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.81.23.8-0.90.30.2-0.2-0.9-0.2-0.92.0-1.10.31.8-1.9-1.60.6-0.3
Pavlov. Cond. response bias1.01.43.6-1.40.90.8-0.8-1.3-0.8-0.41.7-0.61.01.9-1.9-1.50.40.0
Time in closed arm before self-admin0.61.03.91.0-0.9-0.90.90.80.8-0.5-0.5-0.7-0.9-1.92.0-0.1-0.2-1.2
Time in closed arm after self-admin0.60.71.80.3-0.6-0.70.70.00.7-1.31.1-1.3-0.70.6-0.6-1.4-0.5-1.2
Time in open arm before self-admin1.11.42.3-1.21.41.4-1.4-0.9-1.11.5-0.71.51.00.9-0.81.1-0.51.5
Time in open arm after self-admin1.21.32.6-0.81.11.3-1.3-0.5-1.21.6-1.61.61.1-0.60.71.4-0.20.9
Bone: periosteal estimation1.02.44.9-2.22.11.9-1.9-2.2-1.41.20.21.01.51.8-1.7-0.1-1.10.9
Bone: periosteal perimeter0.40.71.4-1.01.21.0-1.0-1.0-0.91.1-0.61.00.80.5-0.40.6-0.60.7
Bone: post-yield work1.83.14.5-2.12.12.1-2.1-1.8-1.92.0-0.61.92.01.5-1.51.2-0.62.0
Progressive ratio test 1 active lever presses1.22.27.91.4-0.7-0.20.21.4-0.10.8-2.80.9-0.1-2.62.71.9-0.6-0.8
Progressive ratio test 1 breakpoint1.11.97.21.3-0.6-0.10.11.3-0.20.8-2.70.9-0.0-2.52.61.7-0.7-0.9
Progressive ratio test 1 inactive lever presses0.82.15.7-0.41.21.3-1.3-0.4-1.42.1-2.42.11.3-1.01.22.1-0.91.0
Progressive ratio test 2 active lever presses1.52.16.91.4-1.0-0.10.11.8-0.50.7-2.50.80.4-2.62.62.00.2-0.4
Progressive ratio test 2 breakpoint1.72.16.91.5-1.0-0.20.21.8-0.50.7-2.50.80.4-2.62.62.00.3-0.4
Progressive ratio test 2 inactive lever presses0.20.83.30.1-0.20.6-0.60.3-0.60.6-1.50.40.5-1.81.80.8-0.4-0.6
Incentive Sensitization - Responses0.20.51.30.9-0.6-0.20.21.0-0.30.4-1.00.40.3-1.11.21.00.40.2
Incentive Sensitization - Breakpoint0.20.61.50.9-0.7-0.30.31.0-0.30.3-1.10.30.3-1.21.21.00.40.2
Sum of active levers in priming session hrs 5-62.12.04.62.0-1.4-1.41.42.11.20.0-1.10.2-1.3-1.91.81.41.30.3
Progressive ratio0.00.10.20.1-0.00.1-0.10.2-0.20.2-0.10.20.2-0.30.40.40.40.2
Food seeking constrained by brief footshock6.68.313.7-2.73.43.6-3.6-2.6-3.73.4-3.03.33.5-0.10.62.1-2.81.4
Seeking ratio, punishment vs. effort0.91.93.2-1.61.71.8-1.8-1.5-1.61.5-1.21.41.50.3-0.10.6-1.80.5
Retroperitoneal fat weight0.31.42.31.0-1.2-1.41.40.91.3-1.51.5-1.3-1.21.0-1.1-1.10.9-0.3
Reaction time number correct0.10.31.0-0.10.40.4-0.4-0.1-0.40.8-1.00.90.4-0.40.50.80.00.3
Reaction time mean minus median0.31.96.8-1.10.20.3-0.3-1.20.1-1.72.5-1.60.11.7-1.7-2.60.2-1.2
Reaction time mean minus median AUC0.21.43.9-1.40.70.9-0.9-1.4-0.6-0.91.9-0.90.71.6-1.6-2.0-0.1-0.7
Reaction time num false alarms0.10.20.8-0.2-0.1-0.10.1-0.10.2-0.50.9-0.4-0.10.3-0.3-0.80.5-0.3
Reaction time num false alarms AUC0.10.20.4-0.70.60.6-0.6-0.7-0.50.30.10.40.50.3-0.2-0.1-0.00.1
Reaction time trials correct on left0.10.31.0-0.10.40.4-0.4-0.1-0.40.8-1.00.90.4-0.40.50.80.00.3
Reaction time trials on left0.10.20.8-0.00.30.3-0.3-0.0-0.30.7-0.90.80.3-0.40.50.80.10.3
Reaction time mean1.43.18.90.8-1.5-1.61.60.61.5-2.53.0-2.5-1.31.2-1.4-2.41.5-1.0
Reaction time mean AUC1.43.49.11.0-1.6-1.71.70.71.6-2.73.0-2.6-1.41.0-1.2-2.51.7-1.1
Median of all reaction times2.23.46.41.6-2.0-2.22.21.51.9-2.42.5-2.3-1.70.7-0.9-1.71.9-0.6
Reaction time omissions0.91.53.01.4-1.6-1.51.51.51.4-1.21.1-1.2-1.2-0.0-0.2-0.41.70.1
Reaction time false alarm rate0.10.20.7-0.0-0.3-0.20.20.00.2-0.60.8-0.6-0.20.2-0.2-0.70.3-0.4
Reaction time premature initiation rate1.82.84.81.8-1.8-2.12.11.32.0-2.10.6-1.9-2.1-0.90.8-1.20.0-2.2
Reaction time premature initiations0.61.73.31.6-1.4-1.71.71.11.6-1.5-0.0-1.2-1.6-1.11.1-0.7-0.0-1.8
Std. dev. reaction times0.72.28.7-0.3-0.5-0.50.5-0.40.7-2.03.0-2.0-0.41.6-1.8-2.71.0-0.8
Reaction time trials completed0.10.20.8-0.00.30.3-0.3-0.0-0.30.7-0.90.80.3-0.40.50.80.10.3
Reaction time trials AUC0.10.20.8-0.00.30.2-0.2-0.0-0.20.7-0.90.80.2-0.30.50.80.10.2
Run reversals in cocaine runway, females0.50.63.0-0.3-0.1-0.30.3-0.31.6-0.61.0-0.6-1.7-0.00.1-0.8-0.3-0.3
Run reversals in cocaine runway, males0.10.10.20.3-0.30.0-0.00.3-0.4-0.3-0.1-0.20.3-0.20.2-0.10.1-0.5
Latency to leave start box in cocaine runway0.30.41.1-0.81.00.8-0.8-1.1-0.80.3-0.10.30.70.3-0.3-0.3-0.9-0.2
Latency to leave start box in cocaine runway, F0.10.10.40.5-0.0-0.10.10.3-0.40.2-0.60.30.4-0.40.40.50.3-0.1
Latency to leave start box in cocaine runway, M1.51.53.0-1.61.71.5-1.5-1.7-1.41.0-0.31.01.20.8-0.60.1-1.50.6
Std. dev. time between licks in bursts0.20.31.30.6-0.8-0.60.60.70.5-0.60.7-0.6-0.40.1-0.2-0.31.10.1
Total sessions with >9 infusions1.11.45.00.60.10.5-0.50.7-1.01.3-2.21.40.9-1.61.71.90.00.2
Short access day 1 total inactive lever presses0.81.65.7-0.11.30.8-0.8-0.6-0.51.7-2.41.90.3-1.11.41.8-1.50.4
Short access day 10 total inactive lever presses0.10.61.9-1.01.30.9-0.9-1.4-0.70.4-0.10.50.70.6-0.5-0.3-1.20.1
Short access day 1 total infusions0.81.56.10.50.40.5-0.50.5-0.71.5-2.51.70.6-1.51.62.2-0.30.5
Short access day 10 total infusions0.81.35.20.7-0.10.3-0.30.9-0.51.2-2.31.30.4-1.61.72.0-0.40.3
Short access total infusions1.21.66.61.1-0.30.1-0.11.2-0.71.2-2.61.40.5-1.71.72.3-0.10.2
Short access day 1 locomotion0.81.33.21.8-1.0-0.80.81.60.20.1-1.50.5-0.3-1.61.61.61.2-0.5
Short access day 10 total locomotion0.31.12.01.3-1.4-1.01.01.10.4-1.20.3-1.1-0.4-1.01.0-0.51.3-1.4
Short access total locomotion0.60.82.81.1-0.6-0.20.21.0-0.20.4-1.40.50.0-1.61.71.20.7-0.2
One hour access (0.3 mA shock)0.91.13.4-0.0-0.10.9-0.90.6-1.31.1-1.80.91.2-1.31.41.3-0.7-0.0
Compulsive drug intake0.40.62.2-0.80.20.2-0.2-0.6-0.3-0.51.1-0.60.41.5-1.5-1.00.0-0.2
One hour access (shock baseline)0.82.07.70.5-0.00.9-0.90.8-1.51.5-2.81.51.3-1.91.92.1-0.80.1
Social response proportion2.12.75.61.1-1.5-1.81.81.11.9-1.82.4-1.7-1.91.6-1.8-1.21.70.1
Social responses0.71.02.6-1.21.21.0-1.0-1.2-0.70.50.50.70.71.6-1.6-0.0-0.20.8
Social time0.81.34.3-0.2-0.1-0.20.20.10.4-0.11.80.0-0.21.9-2.00.01.92.1
Soleus weight0.82.412.1-0.00.50.4-0.40.4-0.82.2-1.22.20.80.7-0.72.71.43.5
Bone: stiffness3.05.512.6-3.22.82.5-2.5-3.0-2.01.41.31.22.23.6-3.4-0.3-0.22.1
Tibialis anterior weight5.418.633.5-5.35.85.6-5.6-5.3-4.84.6-2.34.54.62.4-1.91.5-3.82.7
Time to tail flick, vehicle, before self-admin0.50.61.90.9-1.1-0.50.50.8-0.2-0.9-0.1-0.90.2-0.90.8-0.6-0.4-1.4
Time to tail flick, vehicle, after self-admin0.10.20.7-0.10.00.0-0.0-0.2-0.8-0.3-0.2-0.20.80.7-0.8-0.3-0.4-0.9
Time to tail flick, test, before self-admin0.30.31.2-0.60.30.7-0.7-0.3-0.50.4-0.40.20.4-0.70.70.0-1.1-0.0
Time to tail flick, test, after self-admin1.11.22.7-1.60.91.4-1.4-1.6-0.8-0.20.3-0.40.7-0.00.2-1.4-1.7-1.5
Delta time to tail flick, vehicle, before/after SA0.40.52.4-0.60.60.2-0.2-0.60.00.20.50.30.11.5-1.5-0.00.40.7
Delta time to tail flick, test, before/after SA0.30.31.5-0.10.0-0.20.2-0.40.2-0.90.6-0.7-0.20.3-0.3-1.00.2-1.2
Tibia length0.61.79.2-0.10.60.1-0.1-0.0-0.61.40.01.50.81.6-1.61.71.33.0
Ambulatory time before self-admin1.34.08.7-1.72.42.2-2.2-1.8-2.92.1-1.42.32.91.6-1.51.3-0.91.5
Ambulatory time after self-admin0.40.71.3-0.70.80.8-0.8-0.8-1.00.60.30.61.11.0-1.10.10.90.9
Bone: tissue strength1.21.26.0-0.80.40.2-0.2-0.5-0.3-0.11.5-0.10.52.4-2.5-0.31.11.3
Total heroin consumption1.11.33.11.5-0.8-0.90.91.60.50.6-1.50.8-0.6-1.31.41.81.10.7
Bone: trabecular number0.50.82.2-1.51.21.3-1.3-1.5-0.70.10.40.00.70.6-0.5-0.9-0.8-0.5
Bone: trabecular spacing0.10.10.40.0-0.0-0.20.2-0.20.3-0.50.5-0.4-0.30.1-0.1-0.6-0.2-0.5
Bone: trabecular thickness0.20.20.60.2-0.6-0.20.20.40.2-0.70.5-0.8-0.1-0.30.2-0.60.5-0.6
Bone: trabecular tissue density2.54.48.0-2.52.42.3-2.3-2.4-2.21.60.61.72.32.8-2.70.4-0.02.3
Water consumed over 24 hours0.30.52.2-0.91.00.8-0.8-1.1-0.40.4-0.50.40.4-0.10.3-0.3-1.5-0.6
Number of responses in last shaping day1.62.18.90.70.30.3-0.30.8-1.12.0-2.42.20.9-0.20.33.00.02.0