Hub : Genes

Tob2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Tob2 0.02 0.01 1.6e-03 0.02 0.01 0.01 0.01 7.2e-04 2.0e-03 3.0e-03 2.0e-03
2 Brain mRNA stability Tob2 0.05 0.03 8.5e-06 0.04 0.04 0.04 0.04 2.9e-04 7.2e-05 1.7e-04 2.3e-04
3 PL gene expression Tob2 0.03 0.02 3.6e-04 0.04 0.03 0.04 0.03 2.8e-05 6.6e-04 5.7e-05 1.2e-04
4 Adipose mRNA stability Tob2 0.05 0.03 1.1e-05 0.03 0.03 0.03 0.03 2.1e-04 2.3e-04 2.7e-04 3.4e-04
5 RMTg mRNA stability Tob2 0.12 0.07 9.6e-04 0.06 0.06 0.03 0.03 1.1e-02 1.2e-02 6.7e-02 4.3e-02
6 PL mRNA stability Tob2 0.03 0.02 3.5e-04 0.02 0.03 0.02 0.02 2.3e-03 2.7e-04 1.7e-03 2.7e-03
7 Brain gene expression Tob2 0.06 0.03 7.3e-08 0.07 0.08 0.07 0.06 4.2e-07 1.4e-07 4.2e-07 1.1e-06
8 IL gene expression Tob2 0.2 0.14 7.1e-03 0.04 0.02 0.01 0 3.9e-02 1.0e-01 1.9e-01 2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.30.61.6-0.8-0.70.4-0.3-0.7-0.90.61.3
Area under the delay curve0.40.40.9-0.8-0.80.9-0.8-0.3-0.40.20.4
BMI with tail1.13.76.71.82.0-2.42.62.01.6-1.9-0.6
BMI without tail0.10.20.90.50.4-0.40.60.20.10.10.9
Body weight1.35.77.92.62.5-2.72.82.32.3-2.3-1.3
Weight adjusted by age0.10.10.40.50.10.6-0.40.00.40.4-0.2
Bone surface0.40.61.50.3-0.61.0-0.9-0.7-0.40.91.2
Bone volume0.10.10.60.1-0.20.3-0.2-0.2-0.20.40.8
Breakpoint value in progressive ratio session0.00.10.10.1-0.0-0.20.2-0.3-0.3-0.20.4
Number of licking bursts0.71.11.9-0.7-1.11.4-1.3-0.8-0.80.91.1
Context. condit. distance diff. score7.49.010.82.83.3-2.82.73.13.3-2.6-3.2
Locomotion velocity, session 10.30.30.80.8-0.20.9-0.9-0.10.40.50.1
Locomotion distance, session 13.14.07.0-1.4-2.12.6-2.6-1.9-1.52.11.1
Locomotion velocity, session 20.30.31.21.10.6-0.40.40.60.6-0.3-0.2
Locomotion distance, session 23.34.66.4-1.5-2.52.4-2.2-1.9-2.31.62.5
Locomotion velocity, session 30.30.31.30.60.6-0.0-0.20.30.80.0-1.1
Locomotion distance, session 31.71.83.6-1.5-1.21.7-1.9-1.3-0.61.4-0.5
Stereotopy head waving bouts, day 30.91.12.51.61.1-1.01.11.01.0-0.9-0.0
Stereotopy head waving duration, day 34.14.98.22.92.5-2.32.32.42.2-1.8-0.7
Locomotion velocity, session 70.20.20.7-0.20.4-0.30.20.20.6-0.2-0.8
Locomotion distance, session 70.20.31.5-1.2-0.50.3-0.4-0.3-0.3-0.1-0.3
Stereotopy head waving bouts, day 72.93.26.22.52.1-1.41.51.62.3-0.8-1.7
Stereotopy head waving duration, day 72.93.45.12.22.3-1.81.91.52.1-0.8-1.9
Locomotion velocity, session 82.02.56.02.51.6-1.01.01.91.7-1.5-0.5
Locomotion distance, session 80.91.31.81.31.3-0.80.81.31.3-0.9-1.2
Degree of sensitization distance2.92.95.41.31.6-2.32.31.71.1-2.1-0.5
Degree of sensitization stereotypy2.12.34.02.01.8-1.11.21.31.9-0.6-1.6
Conditioned locomotion0.70.81.30.41.0-0.80.91.11.1-0.6-1.1
Cocaine response after cond. corrected0.10.10.20.30.4-0.30.10.10.4-0.1-0.5
Cocaine response after cond. not corrected0.10.10.20.40.4-0.20.00.20.30.0-0.3
Cocaine response before conditioning0.10.10.2-0.2-0.20.3-0.30.1-0.40.40.5
Saline control response0.20.30.70.90.6-0.1-0.00.70.60.0-0.8
Bone: connectivity density0.10.20.8-0.3-0.40.2-0.1-0.3-0.50.30.9
Bone: cortical apparent density1.11.52.1-1.4-1.31.3-1.4-1.2-1.21.10.7
Bone: cortical area1.52.33.81.91.6-1.61.71.61.5-1.4-0.1
Bone: cortical porosity0.50.61.10.50.9-1.11.00.60.6-0.5-0.5
Bone: cortical porosity1.92.02.91.51.7-1.71.71.31.4-1.1-0.8
Bone: cortical thickness0.20.41.10.30.3-0.60.80.60.2-1.00.8
Bone: cortical thickness0.30.41.20.50.1-0.40.50.90.2-1.10.8
Bone: cortical tissue density1.01.41.9-1.4-1.31.3-1.4-1.1-1.11.10.7
Condit. Reinf. active minus inactive responses0.20.30.8-0.0-0.60.6-0.5-0.3-0.50.20.9
Condit. Reinf. active-inactive response ratio0.30.31.11.10.6-0.30.30.50.6-0.5-0.5
Condit. Reinf. active responses1.31.62.3-1.1-1.41.3-1.2-1.0-1.51.01.5
Condit. Reinf. inactive responses2.53.04.6-2.1-1.91.7-1.5-1.5-2.11.51.4
Incentive salience index mean0.60.71.5-0.5-1.00.8-0.8-0.5-1.00.41.2
Condit. Reinf. lever presses0.81.12.0-1.1-1.21.0-0.9-0.8-1.20.81.4
Condit. Reinf. active minus inactive responses0.20.20.70.6-0.50.4-0.20.1-0.3-0.40.8
Condit. Reinf. active-inactive response ratio0.20.20.90.6-0.2-0.10.2-0.0-0.2-0.60.9
Condit. Reinf. active responses0.40.52.01.40.4-0.20.31.00.6-0.90.0
Condit. Reinf. inactive responses0.81.02.21.20.9-0.40.41.51.2-0.9-0.8
Condit. Reinf. lever presses0.30.41.00.2-0.80.6-0.5-0.5-0.80.41.0
Condit. Reinf. lever reinforcers received0.20.31.31.10.1-0.10.20.70.3-0.70.3
Conditioned reinforcement - actives0.20.40.80.50.5-0.80.30.70.8-0.9-0.3
Conditioned reinforcement - inactives0.30.42.20.3-0.40.4-0.00.2-0.5-0.61.5
Conditioned locomotion1.51.93.61.11.2-1.91.61.51.1-1.70.2
Patch foraging indifference point 0 sec0.40.82.9-0.2-0.80.5-0.5-0.8-1.10.61.7
Patch foraging indifference point AUC0.60.82.5-0.3-1.11.6-1.3-0.6-0.50.70.2
Delay disc. indifference point, 0s delay1.11.22.10.61.3-1.41.31.20.9-1.1-0.7
Delay disc. indifference point, 16s delay1.41.62.4-1.3-1.51.5-1.4-1.2-1.21.00.9
Delay disc. indifference point, 2s delay0.10.10.2-0.5-0.10.20.10.30.1-0.30.0
Delay disc. indifference point, 24s delay0.60.71.8-0.5-0.81.3-1.3-0.8-0.10.60.3
Delay disc. indifference point, 4s delay0.20.20.80.2-0.40.5-0.40.3-0.3-0.30.9
Delay disc. indifference point, 8s delay0.91.11.9-1.4-1.21.2-1.2-0.9-0.90.70.5
Indifference point function ln k0.91.52.81.01.5-1.71.51.01.1-1.0-0.9
Indifference point function log k0.91.52.81.01.5-1.71.51.01.1-1.0-0.9
Patch foraging total patch changes 0 sec0.51.02.9-0.4-1.00.7-0.6-0.9-1.20.71.7
Patch foraging total patch changes 12 sec0.10.10.20.4-0.20.4-0.1-0.0-0.20.00.5
Patch foraging total patch changes 18 sec0.20.41.50.1-0.60.6-0.5-0.2-0.70.11.2
Patch foraging total patch changes 24 sec0.30.50.9-0.3-0.70.9-0.9-0.6-0.60.70.4
Patch foraging total patch changes 6 sec0.71.03.90.5-0.91.1-0.9-0.4-0.90.52.0
Patch foraging time to switch 0 sec0.10.20.5-0.70.4-0.70.6-0.1-0.00.2-0.2
Patch foraging water rate 0 sec0.20.41.30.6-0.60.5-0.3-0.4-0.60.11.2
Patch foraging water rate 12 sec0.30.61.4-0.1-0.60.6-0.9-1.2-0.70.90.7
Patch foraging water rate 18 sec1.32.03.5-0.5-1.41.4-1.5-1.9-1.41.41.6
Patch foraging water rate 24 sec0.20.21.11.10.2-0.40.3-0.2-0.0-0.20.5
Patch foraging water rate 6 sec0.91.32.1-0.3-1.11.4-1.4-1.3-0.91.40.8
Seeking ratio, delayed vs. immediate footshock3.34.05.3-2.3-2.21.5-1.9-2.2-2.31.71.8
Distance traveled before self-admin0.30.40.9-0.9-0.60.70.0-0.2-0.9-0.10.7
Distance traveled after self-admin0.60.74.70.5-0.50.50.1-0.1-0.6-0.02.2
Extensor digitorum longus weight0.10.30.7-0.2-0.40.4-0.4-0.7-0.70.80.6
Bone: elastic displacement0.10.10.40.60.4-0.10.1-0.10.50.2-0.1
Bone: elastic work2.63.46.02.52.0-2.02.01.61.8-1.6-0.6
Bone: endosteal estimation0.92.05.62.41.7-1.11.01.31.6-0.4-1.0
Bone: endosteal perimeter1.83.86.12.52.4-1.91.81.72.4-0.9-1.5
Epididymis fat weight2.89.512.32.43.2-3.53.53.02.9-3.0-3.0
Delta time in closed arm before/after self-admin0.20.20.60.10.10.4-0.00.80.3-0.7-0.0
Delta time in open arm before/after self-admin0.20.20.6-0.3-0.0-0.3-0.5-0.60.00.8-0.4
Diff in mean of infusions in LGA sessions0.10.20.40.60.00.70.10.30.2-0.40.2
Delay discount exponential model param0.50.51.10.80.9-1.10.90.40.5-0.3-0.5
Extinction: sum of active levers before priming0.80.91.41.01.0-1.20.91.00.9-1.1-0.5
Active lever presses in extinction session 60.30.30.50.70.6-0.70.60.40.4-0.5-0.3
Bone: final force1.32.03.11.81.4-1.51.41.61.2-1.7-0.1
Bone: final moment1.42.34.02.01.4-1.61.51.61.3-1.70.0
Food consumed during 24 hour testing period1.31.72.51.31.3-1.41.41.61.2-1.6-0.3
Glucose0.10.10.4-0.5-0.0-0.30.50.1-0.4-0.10.6
Heart weight7.511.616.74.03.7-3.53.54.13.3-3.3-0.9
Delay discount hyperbolic model param0.30.30.80.70.7-0.90.80.20.4-0.2-0.4
Intermittent access intake day 1-15 change0.10.30.7-0.8-0.50.3-0.3-0.4-0.70.50.6
Intermittent access intake escalation0.20.50.7-0.8-0.70.7-0.7-0.6-0.80.70.6
Intermittent access intake escalation 20.40.51.4-1.2-0.60.5-0.6-0.8-0.80.70.3
Intermitt. access day 1 inactive lever presses0.31.01.80.80.5-1.21.31.10.0-1.30.9
Intermitt. access day 15 inactive lever presses0.30.62.30.4-0.30.10.50.8-0.6-1.01.5
Intermitt. access escalation Index0.40.51.5-0.2-0.71.2-0.6-0.4-0.60.41.1
Intermittent access day 1 total infusions0.30.51.40.80.6-0.30.80.90.7-1.2-0.1
Intermittent access day 15 total infusions0.10.10.3-0.4-0.30.6-0.4-0.1-0.30.10.3
Intermittent access terminal intake (last 3 days)0.10.10.4-0.6-0.10.2-0.30.0-0.00.0-0.3
Intermittent access total infusions0.10.10.3-0.00.3-0.10.30.40.3-0.6-0.2
Intermittent access day 1 locomotion0.20.20.40.10.1-0.60.50.3-0.1-0.70.6
Intermittent access day 15 total locomotion0.10.20.60.10.4-0.80.50.20.2-0.5-0.1
Intermittent access total locomotion0.20.30.80.20.4-0.90.70.40.2-0.7-0.2
Intermittent access standard deviation0.40.92.2-0.10.9-1.41.51.00.4-1.1-0.3
Left kidney weight11.051.471.08.47.6-7.07.17.97.3-7.1-4.2
Right kidney weight12.757.872.08.57.9-7.88.18.37.4-7.8-4.3
Cocaine induced anxiety0.71.02.00.60.8-1.31.40.50.7-1.2-0.9
Post-drug Anxiety0.10.10.3-0.3-0.10.10.2-0.5-0.00.0-0.4
Baseline Anxiety1.82.13.7-1.4-1.41.9-1.7-1.3-1.11.70.8
Tail length0.41.63.1-0.7-1.01.6-1.4-1.5-0.91.80.6
Length with tail0.20.91.91.41.1-0.60.90.81.2-0.5-1.0
Length without tail2.27.08.72.82.7-2.93.02.62.5-2.7-1.9
Times rat made contact with spout0.40.41.00.80.4-0.20.21.00.7-1.00.1
Lifetime Intake0.40.51.60.40.5-0.50.81.00.5-1.30.1
Liver weight, left1.22.06.00.81.5-0.90.81.31.9-0.7-2.4
Liver weight, right2.74.710.31.42.5-2.01.72.02.5-1.4-3.2
Locomotor activity2.33.55.92.42.1-2.02.01.62.0-1.4-1.3
Locomotor testing distance0.00.10.2-0.2-0.30.2-0.2-0.4-0.30.30.2
Locomotor testing rearing1.22.33.01.41.7-1.51.41.71.7-1.4-1.4
Locomotion in novel chamber0.20.21.2-0.2-0.20.2-0.7-0.3-0.01.10.1
Locomotion in novel chamber post-restriction0.61.02.1-1.4-0.90.8-1.0-1.1-0.91.2-0.1
Fecal boli incidents, locomotor time 10.20.30.5-0.3-0.60.6-0.4-0.4-0.50.50.7
Change in fecal boli incidents, locomotor task0.50.51.40.90.6-0.10.10.41.2-0.4-0.9
Time >=10cm from walls, locomotor time 10.10.10.30.20.4-0.60.40.10.3-0.4-0.3
Bouts of movement, locomotor time 10.50.52.2-0.20.5-0.70.50.10.6-0.7-1.5
Total resting periods, locomotor time 10.20.30.8-0.50.2-0.60.5-0.10.2-0.6-0.9
Rest time, locomotor task time 10.50.71.6-0.10.5-1.11.30.70.4-1.3-0.4
Distance moved, locomotor task time 10.40.51.00.91.0-0.50.11.00.9-0.3-0.7
Vertical activity count, locomotor time 10.00.10.20.40.20.0-0.30.20.00.20.2
Time >=10cm from walls, locomotor time 20.20.20.6-0.6-0.40.3-0.1-0.6-0.30.50.8
Bouts of movement, locomotor time 20.20.30.9-0.10.3-0.90.90.40.2-0.9-0.3
Total resting periods, locomotor time 20.10.20.7-0.20.1-0.70.80.30.1-0.8-0.1
Rest time, locomotor task time 20.10.10.3-0.4-0.60.4-0.2-0.2-0.40.00.3
Distance moved, locomotor task time 20.70.91.50.71.2-0.90.71.11.1-0.7-0.8
Vertical activity count, locomotor time 20.20.20.40.50.7-0.50.40.60.6-0.2-0.2
Light reinforcement 10.10.21.01.00.40.1-0.30.20.50.20.2
Light reinforcement 20.71.11.50.61.2-1.21.11.11.1-0.9-1.2
Bone: marrow area1.02.26.22.51.7-1.21.01.31.7-0.4-1.0
Bone: maximum diameter3.97.312.53.52.9-2.72.82.72.8-2.3-0.8
Bone: maximum force2.03.55.52.41.8-1.91.92.21.7-2.1-0.1
Bone: maximum moment2.34.06.82.62.0-2.02.02.31.8-2.2-0.1
Mean time between licks in bursts0.30.71.8-1.4-0.80.7-0.5-0.9-0.90.80.8
Mean num. licks in bursts1.62.52.81.51.6-1.61.51.71.6-1.6-1.5
Cd content in liver0.70.81.60.90.8-0.40.51.21.3-1.1-0.6
Co content in liver0.30.31.90.3-0.40.3-0.00.1-0.3-0.31.4
Cu content in liver6.37.58.4-2.1-2.82.8-2.7-2.9-2.92.82.8
Fe content in liver1.11.33.31.81.2-1.21.31.00.8-0.70.4
K content in liver1.31.31.9-0.7-1.21.4-1.2-1.1-1.21.01.1
Mg content in liver1.41.42.2-1.2-1.31.2-1.0-1.1-1.30.81.5
Mn content in liver0.10.10.2-0.00.00.4-0.50.40.30.1-0.5
Na content in liver2.12.33.0-1.6-1.51.3-1.2-1.7-1.61.61.4
Rb content in liver0.10.20.50.6-0.00.1-0.10.40.1-0.50.7
Se content in liver0.50.61.1-0.8-0.60.7-0.9-1.0-0.50.90.1
Sr content in liver2.62.23.9-2.0-1.61.5-1.5-1.4-1.61.20.9
Zn content in liver0.10.10.50.1-0.20.7-0.4-0.3-0.00.40.3
Bone: minimum diameter0.61.02.21.51.2-1.01.00.81.2-0.5-0.6
Time in familiar zone, hab. session 10.10.10.2-0.2-0.10.3-0.30.10.4-0.00.1
Time in novel zone, hab. session 10.90.91.71.11.2-1.21.30.80.7-0.5-0.6
Total zone transitions, hab. session 14.05.69.5-1.8-2.53.1-3.1-2.2-1.92.51.0
Total locomotion distance, hab. session 11.92.65.4-0.8-1.42.3-2.3-1.5-0.92.20.1
Locomotion velocity, hab. session 12.23.26.1-1.0-1.72.4-2.5-1.7-1.22.20.5
Time in familiar zone, hab. session 20.30.31.2-0.80.3-0.1-0.1-0.20.50.4-1.1
Time in novel zone, hab. session 20.30.31.41.2-0.00.00.20.3-0.2-0.40.8
Total zone transitions, hab. session 21.51.93.8-0.1-1.62.0-1.7-0.8-1.21.11.8
Total locomotion distance, hab. session 21.01.32.5-0.3-1.21.5-1.2-0.8-1.11.01.6
Locomotion velocity, hab. session 21.72.33.6-0.7-1.61.9-1.7-1.2-1.51.41.9
Novel to familiar place preference ratio2.83.06.42.51.9-1.61.61.41.9-1.2-1.5
Novelty place preference3.74.07.32.72.2-1.81.81.72.2-1.4-1.8
Time in novel zone, NPP test4.64.99.13.02.4-2.02.01.92.5-1.6-1.9
Total zone transitions, NPP test3.85.410.2-1.5-2.53.2-3.0-2.1-1.82.31.6
Total locomotion distance, NPP test1.82.54.3-0.8-1.72.1-2.0-1.4-1.41.61.4
Locomotion velocity, NPP test2.63.75.6-1.5-2.12.4-2.3-1.8-1.72.01.4
Intraocular pressure0.30.41.40.10.5-0.30.20.40.8-0.5-1.2
Delta distance traveled before/after self-admin0.70.83.51.90.7-0.30.40.81.1-0.40.4
Delta ambulatory time before/after self-admin0.91.15.02.20.8-0.10.30.91.2-0.50.5
Parametrial fat weight0.20.42.0-0.80.3-0.20.10.10.40.2-1.4
Pavlov. Cond. lever latency0.50.61.00.80.9-0.60.70.61.0-0.5-0.9
Pavlov. Cond. magazine entry latency0.81.02.3-1.5-1.20.9-1.0-0.7-1.10.41.0
Pavlov. Cond. change in total contacts1.61.73.9-1.2-1.61.3-1.2-0.8-1.50.52.0
Pavlov. Cond. index score0.50.61.2-1.1-1.00.5-0.6-0.4-1.00.11.0
Pavlov. Cond. latency score0.40.50.9-0.9-0.90.4-0.5-0.4-0.90.10.9
Pavlov. Cond. lever contacts1.61.92.8-1.7-1.61.2-1.2-1.2-1.71.01.3
Pavlov. Cond. magazine entry number0.91.22.81.71.3-1.01.00.71.2-0.3-0.9
Pavlov. Cond. intertrial magazine entries1.01.22.1-0.3-1.21.1-1.0-1.3-1.21.01.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.7-1.3-1.10.7-0.8-0.5-1.00.20.9
Pavlov. Cond. response bias1.11.43.1-1.8-1.41.0-1.1-0.8-1.40.51.1
Pavlov. Cond. lever latency0.71.03.4-0.20.9-0.60.40.91.3-0.7-1.9
Pavlov. Cond. magazine entry latency3.44.16.8-1.2-2.31.7-1.5-2.3-2.61.42.6
Pavlov. Cond. change in total contacts0.71.26.30.7-0.90.2-0.0-0.5-1.3-0.02.5
Pavlov. Cond. index score1.72.35.3-0.5-1.71.1-1.0-1.6-2.11.02.3
Pavlov. Cond. latency score2.43.26.7-0.8-2.01.5-1.3-1.9-2.41.22.6
Pavlov. Cond. lever contacts0.91.23.80.1-1.10.7-0.5-1.0-1.50.92.0
Pavlov. Cond. magazine entry number1.92.34.10.71.8-1.21.11.82.0-1.0-2.0
Pavlov. Cond. intertrial magazine entries1.92.95.81.11.6-1.51.62.41.6-2.2-0.9
Pavlov. Cond. lever-magazine prob. diff.1.92.55.3-0.6-1.81.1-1.0-1.7-2.11.12.3
Pavlov. Cond. response bias1.11.44.6-0.1-1.20.7-0.5-1.2-1.60.82.2
Time in closed arm before self-admin4.55.78.0-2.3-2.22.0-2.0-2.8-2.62.72.3
Time in closed arm after self-admin0.10.10.2-0.50.00.4-0.10.2-0.00.1-0.1
Time in open arm before self-admin0.10.10.9-0.10.00.2-0.00.10.2-0.0-1.0
Time in open arm after self-admin0.20.30.6-0.4-0.1-0.3-0.5-0.70.10.8-0.7
Bone: periosteal estimation1.53.27.52.72.1-1.71.71.72.0-1.0-0.8
Bone: periosteal perimeter3.96.79.13.03.0-2.72.72.43.0-1.8-1.7
Bone: post-yield work0.20.30.60.60.1-0.10.30.70.3-0.80.7
Progressive ratio test 1 active lever presses0.10.10.70.10.00.20.00.50.1-0.8-0.1
Progressive ratio test 1 breakpoint0.10.10.5-0.0-0.10.3-0.20.30.1-0.7-0.1
Progressive ratio test 1 inactive lever presses0.50.72.30.30.2-0.81.01.1-0.2-1.50.8
Progressive ratio test 2 active lever presses0.10.10.40.0-0.30.4-0.30.2-0.1-0.60.2
Progressive ratio test 2 breakpoint0.10.10.3-0.1-0.30.5-0.40.2-0.1-0.50.2
Progressive ratio test 2 inactive lever presses0.40.61.1-0.8-1.01.0-0.9-0.4-1.10.10.4
Incentive Sensitization - Responses0.10.20.6-0.2-0.50.8-0.6-0.2-0.30.00.3
Incentive Sensitization - Breakpoint0.10.10.3-0.1-0.40.6-0.4-0.0-0.2-0.20.3
Sum of active levers in priming session hrs 5-60.00.00.10.10.3-0.30.3-0.00.1-0.0-0.2
Progressive ratio0.00.00.3-0.1-0.2-0.10.1-0.0-0.50.10.1
Food seeking constrained by brief footshock1.41.73.41.21.2-1.11.81.31.3-1.4-0.6
Seeking ratio, punishment vs. effort0.40.61.00.60.7-0.71.00.71.0-1.0-0.3
Retroperitoneal fat weight4.418.922.13.94.6-4.74.64.44.4-4.2-3.8
Reaction time number correct0.91.83.6-1.3-1.11.5-1.9-1.5-0.71.6-0.1
Reaction time mean minus median0.10.30.60.50.7-0.60.50.70.5-0.2-0.8
Reaction time mean minus median AUC0.51.42.40.71.3-1.31.31.11.1-0.9-1.6
Reaction time num false alarms0.00.10.30.00.30.00.00.10.30.5-0.2
Reaction time num false alarms AUC0.10.10.50.10.10.4-0.4-0.10.20.7-0.3
Reaction time trials correct on left0.91.83.6-1.3-1.11.5-1.9-1.5-0.71.6-0.1
Reaction time trials on left1.01.93.9-1.3-1.21.5-2.0-1.6-0.81.7-0.1
Reaction time mean0.00.10.2-0.2-0.20.0-0.2-0.4-0.50.30.2
Reaction time mean AUC0.00.10.2-0.2-0.20.1-0.2-0.4-0.40.30.1
Median of all reaction times0.20.30.6-0.5-0.50.3-0.5-0.8-0.80.50.5
Reaction time omissions0.10.20.5-0.3-0.30.6-0.7-0.3-0.10.7-0.3
Reaction time false alarm rate0.20.30.50.50.7-0.50.70.70.5-0.3-0.3
Reaction time premature initiation rate0.40.63.40.6-0.60.3-0.1-0.4-0.80.11.8
Reaction time premature initiations0.40.72.0-0.0-0.90.7-0.7-0.8-0.90.61.4
Std. dev. reaction times0.30.60.90.90.9-0.80.70.80.7-0.5-0.8
Reaction time trials completed1.01.93.9-1.3-1.21.5-2.0-1.6-0.81.7-0.1
Reaction time trials AUC0.71.43.0-1.1-1.01.3-1.7-1.4-0.61.5-0.1
Run reversals in cocaine runway, females0.50.50.9-0.7-0.40.9-0.8-0.7-0.20.90.2
Run reversals in cocaine runway, males1.01.03.71.20.90.10.10.61.4-0.6-1.9
Latency to leave start box in cocaine runway0.30.30.9-0.00.5-0.90.50.30.3-0.5-0.9
Latency to leave start box in cocaine runway, F0.10.10.2-0.3-0.2-0.0-0.5-0.5-0.30.40.0
Latency to leave start box in cocaine runway, M1.41.32.30.51.1-1.51.31.00.9-1.2-1.3
Std. dev. time between licks in bursts1.41.94.9-0.5-1.51.4-0.9-1.2-1.61.12.2
Total sessions with >9 infusions3.74.58.72.21.8-1.92.22.71.8-2.90.1
Short access day 1 total inactive lever presses1.62.04.72.20.8-1.21.11.60.6-1.61.6
Short access day 10 total inactive lever presses0.51.32.01.11.2-1.41.31.21.1-1.0-0.9
Short access day 1 total infusions1.62.13.51.91.2-1.21.31.91.0-1.90.8
Short access day 10 total infusions1.01.22.50.71.0-1.21.31.40.8-1.6-0.1
Short access total infusions2.02.55.71.61.2-1.31.72.11.1-2.40.6
Short access day 1 locomotion0.60.81.50.70.8-1.01.11.20.4-1.10.6
Short access day 10 total locomotion0.20.40.8-0.7-0.1-0.90.80.2-0.6-0.30.7
Short access total locomotion1.11.32.40.50.9-1.61.51.30.5-1.50.5
One hour access (0.3 mA shock)0.20.31.4-1.2-0.4-0.0-0.1-0.4-0.50.20.1
Compulsive drug intake0.40.51.1-0.0-1.00.9-0.9-0.4-0.50.30.9
One hour access (shock baseline)0.10.21.1-1.00.2-0.40.4-0.2-0.20.1-0.3
Social response proportion0.40.51.40.40.5-1.11.20.5-0.1-0.50.7
Social responses0.10.10.20.2-0.20.4-0.3-0.1-0.00.50.2
Social time1.82.53.2-1.8-1.71.6-1.5-1.4-1.71.41.4
Soleus weight0.20.61.7-0.1-0.91.0-1.0-0.1-0.60.21.3
Bone: stiffness1.22.02.71.51.4-1.61.61.61.2-1.60.1
Tibialis anterior weight0.82.63.5-1.7-1.81.5-1.4-1.7-1.91.21.6
Time to tail flick, vehicle, before self-admin0.10.10.50.70.3-0.3-0.00.30.2-0.00.2
Time to tail flick, vehicle, after self-admin0.71.02.4-0.5-0.61.4-1.1-1.3-0.51.60.1
Time to tail flick, test, before self-admin0.80.82.40.20.9-0.50.90.81.1-0.7-1.6
Time to tail flick, test, after self-admin0.20.20.9-0.7-0.40.9-0.0-0.0-0.20.60.1
Delta time to tail flick, vehicle, before/after SA0.00.00.10.20.10.20.3-0.20.00.00.0
Delta time to tail flick, test, before/after SA2.32.43.3-1.1-1.61.7-1.6-1.2-1.61.61.8
Tibia length0.61.73.41.91.3-1.00.91.41.6-1.4-0.6
Ambulatory time before self-admin0.30.41.0-0.8-0.61.0-0.1-0.1-0.80.00.7
Ambulatory time after self-admin1.31.65.20.1-1.21.6-0.8-0.9-1.11.02.3
Bone: tissue strength0.20.20.70.80.4-0.30.3-0.00.5-0.2-0.2
Total heroin consumption0.20.20.60.70.20.30.20.50.3-0.70.2
Bone: trabecular number0.00.10.4-0.6-0.00.10.0-0.10.10.3-0.3
Bone: trabecular spacing1.11.42.21.41.1-1.31.21.31.1-1.5-0.4
Bone: trabecular thickness0.10.20.5-0.7-0.30.2-0.1-0.4-0.60.50.3
Bone: trabecular tissue density1.82.64.5-1.3-1.61.2-1.2-1.7-2.11.42.0
Water consumed over 24 hours0.30.51.41.20.5-0.30.20.90.7-0.80.2
Number of responses in last shaping day1.11.24.7-1.0-1.00.5-0.3-0.2-1.6-0.12.2