Hub : Genes

Tnrc6c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr10_102914704_102927428	0.02	0.02	3.4e-03	0.01	0.02	0.01	0.01	1.8e-02	5.6e-03	1.4e-02	1.6e-02
2	PL	intron excision ratio	chr10_102936967_102945565	0.03	0.02	1.6e-03	0.01	0.02	0.01	0.01	1.1e-02	3.3e-03	7.1e-03	9.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.0	1.7	1.8	1.3	-1.3
Area under the delay curve	1.6	1.7	1.7	-1.3	1.3
BMI with tail	0.0	0.2	0.2	0.4	-0.4
BMI without tail	1.2	2.5	2.5	1.6	-1.6
Body weight	0.4	1.8	1.8	-1.4	1.3
Weight adjusted by age	0.0	0.0	0.0	-0.1	0.1
Bone surface	0.5	0.8	0.8	-0.9	0.9
Bone volume	0.0	0.0	0.0	0.0	-0.1
Breakpoint value in progressive ratio session	0.0	0.0	0.0	0.0	-0.1
Number of licking bursts	0.0	0.0	0.0	-0.2	0.2
Context. condit. distance diff. score	0.1	0.2	0.2	-0.4	0.4
Locomotion velocity, session 1	0.8	0.9	0.9	-0.9	1.0
Locomotion distance, session 1	2.9	3.7	3.7	1.9	-1.9
Locomotion velocity, session 2	0.7	0.8	0.8	0.9	-0.9
Locomotion distance, session 2	6.6	9.2	9.2	3.0	-3.0
Locomotion velocity, session 3	0.1	0.1	0.2	-0.3	0.4
Locomotion distance, session 3	0.2	0.2	0.2	0.5	-0.5
Stereotopy head waving bouts, day 3	2.0	2.3	2.4	-1.5	1.5
Stereotopy head waving duration, day 3	2.0	2.4	2.5	-1.6	1.5
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	-0.1
Locomotion distance, session 7	3.5	4.4	4.4	2.1	-2.1
Stereotopy head waving bouts, day 7	4.3	4.8	4.9	-2.2	2.2
Stereotopy head waving duration, day 7	6.9	8.4	8.4	-2.9	2.9
Locomotion velocity, session 8	0.7	0.8	0.8	-0.9	0.9
Locomotion distance, session 8	3.2	4.7	4.8	2.2	-2.2
Degree of sensitization distance	3.4	3.4	3.4	1.8	-1.8
Degree of sensitization stereotypy	1.9	2.1	2.1	-1.5	1.4
Conditioned locomotion	0.2	0.3	0.3	0.5	-0.5
Cocaine response after cond. corrected	0.2	0.2	0.2	-0.4	0.4
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.3	0.3
Cocaine response before conditioning	0.0	0.0	0.0	0.2	-0.1
Saline control response	0.0	0.1	0.1	-0.2	0.3
Bone: connectivity density	1.1	1.7	1.7	1.3	-1.3
Bone: cortical apparent density	1.8	2.3	2.4	1.5	-1.5
Bone: cortical area	2.5	3.7	3.8	-2.0	1.9
Bone: cortical porosity	2.4	2.6	2.6	-1.6	1.6
Bone: cortical porosity	3.4	3.7	3.7	-1.9	1.9
Bone: cortical thickness	0.1	0.1	0.1	-0.4	0.3
Bone: cortical thickness	0.0	0.0	0.1	-0.2	0.2
Bone: cortical tissue density	1.9	2.4	2.5	1.5	-1.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.4	-0.4
Condit. Reinf. active responses	0.5	0.6	0.6	0.8	-0.8
Condit. Reinf. inactive responses	0.7	0.9	0.9	1.0	-0.9
Incentive salience index mean	0.0	0.0	0.0	0.1	-0.0
Condit. Reinf. lever presses	0.0	0.1	0.1	0.3	-0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.5	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.5	0.5
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. inactive responses	0.6	0.8	0.8	0.9	-0.9
Condit. Reinf. lever presses	1.1	1.5	1.5	1.2	-1.2
Condit. Reinf. lever reinforcers received	0.2	0.2	0.2	0.5	-0.5
Conditioned reinforcement - actives	1.2	1.2	1.2	1.1	-1.1
Conditioned reinforcement - inactives	0.3	0.3	0.3	-0.5	0.5
Conditioned locomotion	1.5	1.8	1.8	1.3	-1.3
Patch foraging indifference point 0 sec	1.2	2.0	2.0	1.4	-1.4
Patch foraging indifference point AUC	1.7	1.9	2.0	1.4	-1.4
Delay disc. indifference point, 0s delay	1.7	1.9	1.9	-1.4	1.4
Delay disc. indifference point, 16s delay	0.3	0.3	0.3	0.5	-0.5
Delay disc. indifference point, 2s delay	0.5	0.6	0.6	-0.8	0.8
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	-0.1
Delay disc. indifference point, 4s delay	1.8	1.9	2.0	-1.4	1.4
Delay disc. indifference point, 8s delay	5.4	5.5	5.6	-2.3	2.4
Indifference point function ln k	0.0	0.0	0.0	-0.1	-0.0
Indifference point function log k	0.0	0.0	0.0	-0.1	-0.0
Patch foraging total patch changes 0 sec	1.8	2.8	2.9	1.7	-1.7
Patch foraging total patch changes 12 sec	4.4	5.7	5.8	2.4	-2.4
Patch foraging total patch changes 18 sec	2.4	3.1	3.2	1.8	-1.7
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.2	0.3
Patch foraging total patch changes 6 sec	2.3	3.4	3.4	1.8	-1.8
Patch foraging time to switch 0 sec	0.4	0.6	0.6	-0.8	0.8
Patch foraging water rate 0 sec	0.8	1.2	1.2	1.1	-1.1
Patch foraging water rate 12 sec	0.4	0.6	0.6	0.7	-0.8
Patch foraging water rate 18 sec	0.4	0.6	0.6	0.7	-0.8
Patch foraging water rate 24 sec	2.1	2.9	2.9	1.7	-1.7
Patch foraging water rate 6 sec	0.1	0.2	0.2	0.4	-0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.3	-0.3
Distance traveled before self-admin	1.6	1.7	1.8	-1.3	1.3
Distance traveled after self-admin	1.6	1.8	1.8	1.3	-1.4
Extensor digitorum longus weight	1.6	6.2	6.2	2.5	-2.5
Bone: elastic displacement	1.3	1.5	1.5	1.2	-1.2
Bone: elastic work	0.1	0.1	0.2	-0.4	0.4
Bone: endosteal estimation	0.6	1.3	1.3	-1.2	1.1
Bone: endosteal perimeter	4.3	8.8	9.0	-3.0	3.0
Epididymis fat weight	0.0	0.0	0.0	-0.1	0.0
Delta time in closed arm before/after self-admin	0.5	0.5	0.5	-0.7	0.7
Delta time in open arm before/after self-admin	1.2	1.2	1.2	1.1	-1.1
Diff in mean of infusions in LGA sessions	0.3	0.3	0.3	-0.6	0.5
Delay discount exponential model param	2.0	2.1	2.2	1.4	-1.5
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.0	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.3	0.5	-0.5
Bone: final force	1.1	1.8	1.9	-1.4	1.3
Bone: final moment	1.2	1.9	2.0	-1.4	1.4
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.2	0.2
Glucose	0.0	0.0	0.0	0.0	-0.1
Heart weight	0.0	0.1	0.1	-0.3	0.2
Delay discount hyperbolic model param	1.8	1.9	2.0	1.4	-1.4
Intermittent access intake day 1-15 change	0.3	0.3	0.4	-0.6	0.6
Intermittent access intake escalation	0.1	0.1	0.1	-0.3	0.4
Intermittent access intake escalation 2	0.0	0.0	0.0	0.2	-0.1
Intermitt. access day 1 inactive lever presses	2.6	2.8	2.8	-1.7	1.7
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.3	0.5	-0.5
Intermitt. access escalation Index	1.1	0.9	0.9	-1.0	1.0
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.1	0.1
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.2	0.2
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.2	-0.5	0.5
Intermittent access total infusions	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 1 locomotion	0.8	0.8	0.8	0.9	-0.9
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.1	0.1
Intermittent access total locomotion	0.4	0.4	0.4	0.6	-0.7
Intermittent access standard deviation	5.0	5.3	5.3	-2.3	2.3
Left kidney weight	3.3	9.3	9.4	-3.1	3.0
Right kidney weight	1.2	3.3	3.3	-1.8	1.8
Cocaine induced anxiety	0.7	0.8	0.8	-0.9	0.9
Post-drug Anxiety	0.0	0.0	0.0	-0.1	0.1
Baseline Anxiety	0.1	0.1	0.1	0.2	-0.2
Tail length	0.1	0.2	0.2	0.5	-0.4
Length with tail	1.4	5.0	5.0	-2.2	2.2
Length without tail	4.2	9.1	9.2	-3.0	3.0
Times rat made contact with spout	0.2	0.3	0.3	0.5	-0.5
Lifetime Intake	0.1	0.2	0.2	-0.4	0.4
Liver weight, left	3.3	5.2	5.3	-2.3	2.3
Liver weight, right	1.1	1.8	1.8	-1.3	1.3
Locomotor activity	0.0	0.0	0.0	0.2	-0.2
Locomotor testing distance	0.0	0.0	0.0	0.0	-0.1
Locomotor testing rearing	1.0	1.5	1.5	1.2	-1.2
Locomotion in novel chamber	0.3	0.3	0.3	0.6	-0.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	-0.3	0.3
Fecal boli incidents, locomotor time 1	0.7	0.7	0.7	0.8	-0.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.2	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.3	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.3	0.3
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.3	-0.3
Vertical activity count, locomotor time 1	1.2	1.2	1.3	1.1	-1.1
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.3	0.5	-0.5
Bouts of movement, locomotor time 2	0.2	0.2	0.2	-0.4	0.4
Total resting periods, locomotor time 2	0.2	0.2	0.2	-0.4	0.4
Rest time, locomotor task time 2	0.4	0.4	0.5	-0.7	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.4	-0.3
Vertical activity count, locomotor time 2	0.2	0.3	0.3	0.5	-0.5
Light reinforcement 1	2.2	4.0	4.1	2.0	-2.0
Light reinforcement 2	0.1	0.1	0.1	0.3	-0.3
Bone: marrow area	0.6	1.4	1.4	-1.2	1.2
Bone: maximum diameter	7.0	12.8	13.0	-3.6	3.5
Bone: maximum force	1.0	1.7	1.7	-1.3	1.3
Bone: maximum moment	1.0	1.7	1.8	-1.4	1.3
Mean time between licks in bursts	0.0	0.0	0.0	-0.0	0.0
Mean num. licks in bursts	0.7	0.8	0.8	0.9	-0.9
Cd content in liver	1.0	1.1	1.1	1.0	-1.1
Co content in liver	0.7	0.8	0.8	0.9	-0.9
Cu content in liver	0.0	0.0	0.0	-0.1	0.1
Fe content in liver	0.1	0.1	0.1	-0.4	0.4
K content in liver	0.0	0.0	0.0	-0.0	0.1
Mg content in liver	1.9	1.9	1.9	1.4	-1.4
Mn content in liver	1.1	1.2	1.2	-1.1	1.1
Na content in liver	0.5	0.6	0.6	-0.7	0.8
Rb content in liver	3.0	3.7	3.8	1.9	-1.9
Se content in liver	0.2	0.2	0.2	0.5	-0.4
Sr content in liver	0.0	0.0	0.0	-0.2	0.2
Zn content in liver	1.4	1.6	1.6	-1.3	1.2
Bone: minimum diameter	2.3	4.4	4.5	-2.1	2.1
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.2	-0.2
Time in novel zone, hab. session 1	0.5	0.5	0.5	-0.7	0.7
Total zone transitions, hab. session 1	2.4	3.4	3.4	1.8	-1.8
Total locomotion distance, hab. session 1	2.1	2.9	2.9	1.7	-1.7
Locomotion velocity, hab. session 1	2.8	4.0	4.0	2.0	-2.0
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3
Time in novel zone, hab. session 2	0.5	0.5	0.5	-0.7	0.7
Total zone transitions, hab. session 2	7.4	9.6	9.6	3.1	-3.1
Total locomotion distance, hab. session 2	7.1	9.4	9.4	3.1	-3.1
Locomotion velocity, hab. session 2	7.1	9.5	9.5	3.1	-3.1
Novel to familiar place preference ratio	2.9	3.0	3.0	1.7	-1.7
Novelty place preference	2.2	2.2	2.2	1.5	-1.5
Time in novel zone, NPP test	2.6	2.7	2.7	1.6	-1.7
Total zone transitions, NPP test	5.1	7.2	7.3	2.7	-2.7
Total locomotion distance, NPP test	9.2	12.6	12.6	3.6	-3.5
Locomotion velocity, NPP test	7.8	11.0	11.1	3.3	-3.3
Intraocular pressure	0.7	1.0	1.0	1.0	-1.0
Delta distance traveled before/after self-admin	4.1	4.4	4.5	2.1	-2.1
Delta ambulatory time before/after self-admin	4.4	4.9	4.9	2.2	-2.2
Parametrial fat weight	0.0	0.0	0.0	-0.0	0.0
Pavlov. Cond. lever latency	0.5	0.6	0.6	0.8	-0.8
Pavlov. Cond. magazine entry latency	2.7	3.5	3.6	-1.9	1.9
Pavlov. Cond. change in total contacts	0.3	0.3	0.3	0.5	-0.6
Pavlov. Cond. index score	1.6	2.0	2.0	-1.4	1.4
Pavlov. Cond. latency score	2.1	2.7	2.8	-1.6	1.7
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. magazine entry number	3.6	4.4	4.4	2.1	-2.1
Pavlov. Cond. intertrial magazine entries	2.3	2.8	2.8	1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	1.4	-1.2	1.2
Pavlov. Cond. response bias	1.5	1.8	1.8	-1.4	1.4
Pavlov. Cond. lever latency	1.3	1.7	1.8	-1.3	1.3
Pavlov. Cond. magazine entry latency	0.5	0.6	0.6	0.7	-0.8
Pavlov. Cond. change in total contacts	1.1	1.6	1.6	1.2	-1.3
Pavlov. Cond. index score	0.9	1.1	1.2	1.1	-1.1
Pavlov. Cond. latency score	0.5	0.6	0.7	0.8	-0.8
Pavlov. Cond. lever contacts	1.3	1.7	1.7	1.3	-1.3
Pavlov. Cond. magazine entry number	1.0	1.3	1.3	-1.1	1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.3	1.1	-1.1
Pavlov. Cond. response bias	1.1	1.5	1.5	1.2	-1.2
Time in closed arm before self-admin	0.0	0.0	0.0	0.2	-0.2
Time in closed arm after self-admin	2.4	2.4	2.5	-1.6	1.5
Time in open arm before self-admin	0.4	0.4	0.4	-0.7	0.7
Time in open arm after self-admin	0.6	0.7	0.7	0.8	-0.8
Bone: periosteal estimation	2.1	4.3	4.4	-2.1	2.0
Bone: periosteal perimeter	6.0	10.1	10.2	-3.2	3.1
Bone: post-yield work	0.7	0.9	0.9	0.9	-1.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.2	-0.3
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.3	-0.6	0.6
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.5	-0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.3	0.5	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.1	0.1
Incentive Sensitization - Responses	0.5	0.5	0.5	-0.7	0.7
Incentive Sensitization - Breakpoint	0.7	0.7	0.7	-0.9	0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.3	0.3
Progressive ratio	0.0	0.0	0.0	0.1	-0.2
Food seeking constrained by brief footshock	0.6	0.7	0.7	-0.8	0.8
Seeking ratio, punishment vs. effort	0.4	0.5	0.5	-0.7	0.7
Retroperitoneal fat weight	0.4	1.3	1.3	-1.1	1.1
Reaction time number correct	3.5	5.1	5.2	2.3	-2.2
Reaction time mean minus median	0.6	0.8	0.8	-0.9	0.9
Reaction time mean minus median AUC	1.2	1.5	1.5	-1.2	1.2
Reaction time num false alarms	0.1	0.2	0.2	0.4	-0.4
Reaction time num false alarms AUC	0.4	0.5	0.5	0.7	-0.7
Reaction time trials correct on left	3.5	5.1	5.2	2.3	-2.2
Reaction time trials on left	3.5	5.0	5.1	2.2	-2.2
Reaction time mean	0.0	0.1	0.1	-0.2	0.2
Reaction time mean AUC	0.0	0.0	0.0	-0.0	-0.0
Median of all reaction times	0.0	0.0	0.0	-0.1	0.1
Reaction time omissions	0.7	1.0	1.0	-1.0	1.0
Reaction time false alarm rate	0.2	0.3	0.3	-0.5	0.5
Reaction time premature initiation rate	3.3	4.5	4.5	2.1	-2.1
Reaction time premature initiations	6.9	9.8	9.9	3.1	-3.1
Std. dev. reaction times	0.1	0.1	0.1	-0.3	0.3
Reaction time trials completed	3.5	5.0	5.1	2.2	-2.2
Reaction time trials AUC	4.2	6.1	6.1	2.5	-2.5
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.3	0.3
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.0	-0.0
Latency to leave start box in cocaine runway	0.5	0.5	0.5	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.6	0.7	0.7	0.8	-0.8
Latency to leave start box in cocaine runway, M	1.1	1.1	1.1	1.0	-1.0
Std. dev. time between licks in bursts	1.7	2.0	2.0	1.4	-1.4
Total sessions with >9 infusions	0.7	0.8	0.9	-0.9	0.9
Short access day 1 total inactive lever presses	0.3	0.3	0.3	-0.6	0.6
Short access day 10 total inactive lever presses	1.3	1.4	1.4	-1.2	1.2
Short access day 1 total infusions	1.1	1.1	1.2	-1.1	1.0
Short access day 10 total infusions	1.2	1.3	1.3	-1.2	1.1
Short access total infusions	0.1	0.1	0.2	-0.4	0.4
Short access day 1 locomotion	0.3	0.3	0.3	-0.6	0.5
Short access day 10 total locomotion	0.3	0.3	0.3	-0.6	0.6
Short access total locomotion	0.7	0.7	0.7	-0.8	0.8
One hour access (0.3 mA shock)	0.2	0.3	0.3	0.5	-0.5
Compulsive drug intake	0.7	0.7	0.7	0.8	-0.9
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	0.1
Social response proportion	0.6	0.6	0.6	0.8	-0.8
Social responses	0.1	0.1	0.1	0.4	-0.3
Social time	0.7	0.9	0.9	1.0	-1.0
Soleus weight	0.7	2.1	2.1	1.4	-1.4
Bone: stiffness	1.4	2.3	2.3	-1.5	1.5
Tibialis anterior weight	0.2	0.6	0.6	0.8	-0.8
Time to tail flick, vehicle, before self-admin	0.7	0.7	0.7	0.8	-0.8
Time to tail flick, vehicle, after self-admin	1.1	1.1	1.2	-1.1	1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.4	-0.4
Time to tail flick, test, after self-admin	0.7	0.7	0.7	-0.8	0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	0.3
Delta time to tail flick, test, before/after SA	1.4	1.2	1.3	-1.1	1.1
Tibia length	14.8	41.6	41.8	-6.4	6.5
Ambulatory time before self-admin	2.5	2.6	2.7	-1.6	1.6
Ambulatory time after self-admin	0.5	0.5	0.6	0.7	-0.7
Bone: tissue strength	1.0	1.0	1.0	1.0	-1.0
Total heroin consumption	2.6	3.0	3.1	-1.8	1.7
Bone: trabecular number	0.2	0.3	0.3	0.6	-0.6
Bone: trabecular spacing	0.2	0.3	0.3	-0.5	0.5
Bone: trabecular thickness	0.6	0.7	0.7	0.8	-0.8
Bone: trabecular tissue density	0.1	0.1	0.1	-0.3	0.4
Water consumed over 24 hours	0.1	0.1	0.2	0.4	-0.3
Number of responses in last shaping day	2.2	2.3	2.3	-1.5	1.5