Tnrc6c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	intron excision ratio	chr10_103369293_103412284	0.14	0.12	6.5e-03	0.06	0.06	0.06	0.06	1.3e-02	1.4e-02	1.5e-02	1.3e-02
2	LHb	intron excision ratio	chr10_103387839_103412284	0.16	0.13	4.4e-03	0.07	0.06	0.04	0.06	1.1e-02	1.3e-02	5.1e-02	1.2e-02
3	PL	intron excision ratio	chr10_103413413_103426137	0.02	0.02	3.4e-03	0.01	0.02	0.01	0.01	1.2e-02	4.3e-03	7.4e-03	9.5e-03
4	PL	intron excision ratio	chr10_103435676_103444269	0.03	0.03	1.1e-03	0.02	0.02	0.02	0.02	1.5e-03	1.4e-03	1.3e-03	2.2e-03
5	Liver	intron excision ratio	chr10_103369293_103412284	0.05	0.13	4.3e-03	0.02	0.01	0.02	0.02	1.9e-03	2.9e-02	1.3e-03	3.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.9	1.6	2.7	1.1	-1.1	1.4	1.6	-1.0
Area under the delay curve	0.6	0.8	1.7	-0.6	0.6	-1.2	-1.3	0.7
BMI with tail	0.3	1.0	1.8	-1.3	1.3	-0.2	0.2	-1.2
BMI without tail	0.2	1.2	2.8	0.7	-0.7	1.1	1.1	1.7
Body weight	0.6	2.8	5.0	-2.2	2.2	-1.5	-1.2	-0.6
Weight adjusted by age	0.0	0.1	0.2	-0.3	0.3	-0.0	-0.0	-0.4
Bone surface	0.5	0.9	1.8	-0.9	0.9	-0.9	-0.7	-1.3
Bone volume	0.2	0.5	2.0	-0.4	0.4	0.0	0.2	-1.4
Breakpoint value in progressive ratio session	0.4	0.8	1.4	-1.1	1.1	-0.0	0.3	-1.2
Number of licking bursts	0.0	0.1	0.3	-0.2	0.2	-0.2	-0.2	0.5
Context. condit. distance diff. score	0.3	0.3	0.4	-0.7	0.7	-0.5	-0.4	-0.6
Locomotion velocity, session 1	0.5	0.6	1.3	-0.4	0.4	-1.0	-1.1	0.6
Locomotion distance, session 1	2.3	3.0	3.7	1.8	-1.8	1.9	1.8	1.4
Locomotion velocity, session 2	0.4	0.5	0.8	0.7	-0.7	0.9	0.8	0.1
Locomotion distance, session 2	5.2	7.2	9.5	2.9	-2.9	3.1	3.0	1.2
Locomotion velocity, session 3	0.6	0.7	2.3	0.4	-0.4	-0.4	-0.7	1.5
Locomotion distance, session 3	0.3	0.3	0.7	0.4	-0.4	0.5	0.4	0.8
Stereotopy head waving bouts, day 3	2.5	3.0	3.6	-1.9	1.9	-1.6	-1.4	-1.8
Stereotopy head waving duration, day 3	2.3	2.8	3.4	-1.8	1.8	-1.5	-1.4	-1.7
Locomotion velocity, session 7	0.2	0.2	0.5	0.5	-0.5	0.1	-0.0	0.7
Locomotion distance, session 7	2.8	3.6	4.7	2.0	-2.0	2.2	2.2	0.8
Stereotopy head waving bouts, day 7	4.4	5.1	5.9	-2.4	2.4	-2.4	-2.3	-1.5
Stereotopy head waving duration, day 7	5.8	7.2	8.5	-2.8	2.8	-2.9	-2.8	-1.9
Locomotion velocity, session 8	0.4	0.5	0.9	-0.6	0.6	-0.8	-0.9	-0.2
Locomotion distance, session 8	2.0	3.0	4.6	1.6	-1.6	2.2	2.1	0.5
Degree of sensitization distance	2.9	3.1	3.9	2.0	-2.0	1.9	1.9	0.7
Degree of sensitization stereotypy	1.4	1.6	2.2	-1.3	1.3	-1.5	-1.4	-0.4
Conditioned locomotion	0.6	0.7	1.5	0.8	-0.8	0.6	0.6	1.2
Cocaine response after cond. corrected	0.2	0.3	0.6	-0.5	0.5	-0.4	-0.3	-0.8
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.1	0.1	-0.3	-0.3	-0.5
Cocaine response before conditioning	0.3	0.3	0.7	0.8	-0.8	0.2	-0.0	0.5
Saline control response	1.5	2.1	6.7	1.4	-1.4	0.2	-0.3	2.6
Bone: connectivity density	1.1	1.7	2.4	1.5	-1.5	1.4	1.4	-0.0
Bone: cortical apparent density	0.9	1.5	3.0	0.8	-0.8	1.6	1.7	-0.7
Bone: cortical area	3.8	6.1	8.2	-2.9	2.9	-2.2	-1.9	-2.3
Bone: cortical porosity	1.9	2.0	2.5	-1.3	1.3	-1.6	-1.5	-1.3
Bone: cortical porosity	2.6	2.9	3.8	-1.7	1.7	-2.0	-1.9	-1.2
Bone: cortical thickness	0.4	0.6	0.9	-0.9	0.9	-0.6	-0.5	-1.0
Bone: cortical thickness	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.1	-0.1
Bone: cortical tissue density	1.0	1.6	3.2	0.8	-0.8	1.7	1.8	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.5	-0.5	0.3	0.2	0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.4	-0.4	0.4	0.4	-0.9
Condit. Reinf. active responses	0.9	1.1	2.1	1.2	-1.2	0.8	0.5	1.4
Condit. Reinf. inactive responses	1.3	1.7	4.5	1.2	-1.2	0.8	0.6	2.1
Incentive salience index mean	0.1	0.1	0.3	0.3	-0.3	0.1	-0.1	0.5
Condit. Reinf. lever presses	0.3	0.5	1.3	0.7	-0.7	0.4	0.3	1.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	0.0	-0.0	-0.5	-0.7	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.2	-0.2	-0.4	-0.6	0.3
Condit. Reinf. active responses	0.1	0.2	0.3	0.4	-0.4	0.5	0.4	-0.5
Condit. Reinf. inactive responses	0.5	0.7	1.3	0.8	-0.8	1.1	1.1	0.0
Condit. Reinf. lever presses	0.7	1.0	1.7	0.9	-0.9	1.3	1.2	0.3
Condit. Reinf. lever reinforcers received	0.3	0.5	0.8	0.4	-0.4	0.7	0.8	-0.9
Conditioned reinforcement - actives	0.2	0.7	1.7	0.4	-0.4	1.0	1.3	-0.3
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	-0.2
Conditioned locomotion	0.8	1.2	2.8	0.8	-0.8	1.4	1.7	-0.4
Patch foraging indifference point 0 sec	0.5	1.3	2.3	0.9	-0.9	1.5	1.4	0.5
Patch foraging indifference point AUC	0.9	2.1	3.5	1.7	-1.7	1.1	0.7	1.9
Delay disc. indifference point, 0s delay	0.6	0.7	1.6	-0.4	0.4	-1.2	-1.2	0.3
Delay disc. indifference point, 16s delay	0.2	0.3	0.7	0.5	-0.5	0.4	0.4	0.8
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	-0.1	0.1	-0.7	-0.7	0.9
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.1
Delay disc. indifference point, 4s delay	0.9	1.0	2.1	-0.6	0.6	-1.3	-1.5	0.6
Delay disc. indifference point, 8s delay	2.0	3.3	5.6	-1.6	1.6	-2.4	-2.4	0.1
Indifference point function ln k	0.2	0.7	2.3	-0.7	0.7	0.2	0.6	-1.5
Indifference point function log k	0.2	0.7	2.3	-0.7	0.7	0.2	0.6	-1.5
Patch foraging total patch changes 0 sec	0.6	1.7	3.1	1.1	-1.1	1.8	1.7	0.4
Patch foraging total patch changes 12 sec	3.7	5.0	5.5	2.3	-2.3	2.3	1.9	2.3
Patch foraging total patch changes 18 sec	1.4	3.4	4.6	1.8	-1.8	1.8	1.6	2.1
Patch foraging total patch changes 24 sec	0.1	0.2	0.5	-0.2	0.2	-0.4	-0.7	0.4
Patch foraging total patch changes 6 sec	1.4	2.3	3.2	1.5	-1.5	1.8	1.6	1.3
Patch foraging time to switch 0 sec	0.1	0.3	0.4	-0.5	0.5	-0.7	-0.6	-0.0
Patch foraging water rate 0 sec	0.3	1.3	1.5	1.2	-1.2	1.2	1.0	1.0
Patch foraging water rate 12 sec	0.2	0.6	1.2	0.2	-0.2	0.9	1.1	-1.1
Patch foraging water rate 18 sec	0.1	0.3	0.9	0.1	-0.1	0.8	0.9	-0.2
Patch foraging water rate 24 sec	1.4	2.0	2.9	1.2	-1.2	1.7	1.7	1.0
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.2	-0.2	0.5	0.5	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.5	-0.5	0.0	-0.2	-0.1
Distance traveled before self-admin	0.2	0.4	0.9	-0.2	0.2	-0.8	-1.0	0.3
Distance traveled after self-admin	0.8	1.3	2.3	1.1	-1.1	1.4	1.5	0.2
Extensor digitorum longus weight	1.3	5.0	6.0	2.1	-2.1	2.4	2.4	2.1
Bone: elastic displacement	1.0	1.3	1.8	1.2	-1.2	1.3	1.3	0.4
Bone: elastic work	0.6	0.8	1.6	-1.0	1.0	-0.5	-0.2	-1.3
Bone: endosteal estimation	1.1	2.7	3.9	-2.0	2.0	-1.3	-0.9	-1.8
Bone: endosteal perimeter	4.2	10.3	13.5	-3.7	3.7	-3.2	-2.7	-2.6
Epididymis fat weight	0.1	0.3	0.4	-0.6	0.6	0.2	0.6	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	0.3	-0.3	0.0	-0.1	0.7
Delta time in open arm before/after self-admin	0.9	1.0	1.2	1.1	-1.1	0.9	0.9	1.0
Diff in mean of infusions in LGA sessions	0.8	1.5	2.5	-1.6	1.6	-0.8	-0.5	-1.3
Delay discount exponential model param	0.8	1.1	2.1	0.7	-0.7	1.4	1.4	-0.6
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	0.2	0.4	0.5	-0.3
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.3	0.3	0.4	0.6	-0.2
Bone: final force	1.9	3.1	4.6	-2.0	2.0	-1.4	-1.2	-2.1
Bone: final moment	2.4	3.8	5.9	-2.1	2.1	-1.5	-1.3	-2.4
Food consumed during 24 hour testing period	0.1	0.3	0.9	0.1	-0.1	-0.3	-0.5	0.9
Glucose	0.5	0.7	1.1	-1.0	1.0	-0.9	-0.6	-0.7
Heart weight	0.6	1.0	1.9	-1.4	1.4	-0.8	-0.5	-0.7
Delay discount hyperbolic model param	0.8	1.1	2.1	0.7	-0.7	1.4	1.4	-0.6
Intermittent access intake day 1-15 change	0.1	0.3	0.8	-0.2	0.2	-0.8	-0.9	0.6
Intermittent access intake escalation	0.0	0.2	0.4	-0.0	0.0	-0.6	-0.7	0.1
Intermittent access intake escalation 2	0.1	0.2	0.3	-0.1	0.1	-0.5	-0.5	0.6
Intermitt. access day 1 inactive lever presses	0.1	1.0	2.1	-0.9	0.9	-0.8	-0.7	-1.5
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.3	0.6	-0.6	0.5	0.5	0.6
Intermitt. access escalation Index	0.1	0.2	0.6	-0.2	0.2	-0.7	-0.8	0.2
Intermittent access day 1 total infusions	0.3	0.8	2.5	-0.7	0.7	0.3	0.7	-1.6
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.1	-0.1	0.2	0.3	-0.5
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.9	-0.6	0.6	-0.3	-0.2	-0.9
Intermittent access total infusions	0.6	0.7	2.3	-0.8	0.8	-0.1	0.2	-1.5
Intermittent access day 1 locomotion	0.5	0.9	1.9	0.4	-0.4	1.2	1.4	-0.9
Intermittent access day 15 total locomotion	0.0	0.2	0.7	-0.2	0.2	0.2	0.3	-0.8
Intermittent access total locomotion	0.5	0.6	1.8	-0.2	0.2	0.6	0.8	-1.3
Intermittent access standard deviation	1.4	7.3	9.8	-3.1	3.1	-2.8	-2.5	-1.8
Left kidney weight	0.7	5.7	8.5	-2.9	2.9	-2.4	-2.1	-1.3
Right kidney weight	0.2	1.4	2.5	-1.6	1.6	-1.1	-0.9	-0.6
Cocaine induced anxiety	0.1	0.4	0.8	-0.2	0.2	-0.8	-0.9	0.5
Post-drug Anxiety	0.1	0.2	0.6	0.2	-0.2	-0.1	-0.2	0.8
Baseline Anxiety	0.2	0.3	0.7	0.2	-0.2	0.7	0.8	-0.5
Tail length	0.2	1.2	5.3	0.6	-0.6	-0.1	-0.5	2.3
Length with tail	0.9	3.8	5.4	-2.1	2.1	-2.3	-2.3	0.0
Length without tail	1.5	7.9	9.7	-3.1	3.1	-2.8	-2.5	-2.4
Times rat made contact with spout	0.4	0.5	1.1	0.6	-0.6	0.6	0.6	1.0
Lifetime Intake	0.8	0.9	2.8	-1.0	1.0	-0.1	0.2	-1.7
Liver weight, left	1.6	2.8	3.9	-2.0	2.0	-1.5	-1.4	-1.3
Liver weight, right	0.8	1.4	2.1	-1.2	1.2	-1.4	-1.3	-0.5
Locomotor activity	0.1	0.1	0.2	0.2	-0.2	0.2	0.3	-0.5
Locomotor testing distance	0.1	0.4	1.3	-0.1	0.1	0.3	0.5	-1.2
Locomotor testing rearing	0.4	1.4	2.0	1.4	-1.4	1.2	1.2	0.0
Locomotion in novel chamber	0.5	0.7	1.3	0.9	-0.9	0.5	0.4	1.2
Locomotion in novel chamber post-restriction	0.1	0.4	0.8	-0.7	0.7	-0.5	-0.4	-0.9
Fecal boli incidents, locomotor time 1	0.1	0.4	0.8	0.0	-0.0	0.7	0.9	-0.8
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.0	0.0	0.1	0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.0	-0.0	-0.3	-0.5	-0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	0.2	0.3	-0.1
Total resting periods, locomotor time 1	0.1	0.2	0.2	0.5	-0.5	0.3	0.5	-0.0
Rest time, locomotor task time 1	0.4	0.7	1.6	-0.9	0.9	-0.5	-0.2	-1.3
Distance moved, locomotor task time 1	0.1	0.4	1.3	0.5	-0.5	0.2	0.0	1.1
Vertical activity count, locomotor time 1	0.4	2.5	5.0	1.6	-1.6	1.1	0.9	2.2
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	0.7	-0.7	0.4	0.3	0.4
Bouts of movement, locomotor time 2	0.1	0.3	0.5	-0.6	0.6	-0.4	-0.1	-0.7
Total resting periods, locomotor time 2	0.1	0.4	0.9	-0.6	0.6	-0.4	-0.1	-0.9
Rest time, locomotor task time 2	0.7	1.2	2.8	-1.1	1.1	-0.7	-0.4	-1.7
Distance moved, locomotor task time 2	0.3	0.5	1.3	0.6	-0.6	0.4	0.1	1.1
Vertical activity count, locomotor time 2	0.2	0.5	1.2	0.6	-0.6	0.5	0.5	1.1
Light reinforcement 1	1.0	4.6	5.0	2.2	-2.2	2.2	1.9	2.2
Light reinforcement 2	0.3	0.8	2.8	0.7	-0.7	0.4	0.1	1.7
Bone: marrow area	1.1	2.6	3.8	-1.9	1.9	-1.3	-0.9	-1.8
Bone: maximum diameter	7.9	15.9	20.2	-4.5	4.5	-3.9	-3.4	-3.5
Bone: maximum force	1.9	3.8	6.9	-2.2	2.2	-1.4	-1.0	-2.6
Bone: maximum moment	2.4	4.5	8.5	-2.3	2.3	-1.5	-1.1	-2.9
Mean time between licks in bursts	0.0	0.1	0.5	-0.3	0.3	-0.2	-0.1	-0.7
Mean num. licks in bursts	0.2	0.6	1.0	0.8	-0.8	1.0	1.0	0.2
Cd content in liver	1.1	1.2	2.2	1.0	-1.0	1.4	1.5	-0.3
Co content in liver	0.1	0.1	0.3	-0.1	0.1	0.1	0.1	-0.6
Cu content in liver	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3	-0.0
Fe content in liver	0.1	0.1	0.6	0.2	-0.2	-0.1	-0.2	0.8
K content in liver	0.3	0.3	0.6	0.8	-0.8	0.4	0.2	-0.0
Mg content in liver	2.1	2.3	3.1	1.8	-1.8	1.7	1.5	0.2
Mn content in liver	0.1	0.1	0.2	-0.0	0.0	-0.4	-0.5	0.1
Na content in liver	0.2	0.2	1.0	-0.3	0.3	-0.1	-0.1	-1.0
Rb content in liver	1.6	1.9	2.3	1.5	-1.5	1.5	1.4	0.8
Se content in liver	1.2	1.4	2.1	1.4	-1.4	1.0	0.8	1.1
Sr content in liver	0.2	0.2	0.7	-0.1	0.1	0.1	0.2	-0.8
Zn content in liver	0.1	0.1	0.1	-0.3	0.3	-0.2	-0.2	-0.4
Bone: minimum diameter	3.6	6.9	8.1	-2.8	2.8	-2.4	-2.1	-2.8
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	-0.4	0.3	0.2	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.3	0.3	-0.7	-0.8	-0.5
Total zone transitions, hab. session 1	1.5	2.1	3.0	1.4	-1.4	1.7	1.6	0.9
Total locomotion distance, hab. session 1	1.6	2.2	2.8	1.5	-1.5	1.7	1.6	1.1
Locomotion velocity, hab. session 1	2.0	2.8	3.9	1.6	-1.6	2.0	1.9	1.3
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.1	0.1	0.3	0.3	-0.2
Time in novel zone, hab. session 2	0.3	0.4	0.6	-0.4	0.4	-0.7	-0.6	-0.8
Total zone transitions, hab. session 2	4.9	6.3	9.1	2.5	-2.5	3.0	3.0	1.0
Total locomotion distance, hab. session 2	5.5	7.2	9.5	2.8	-2.8	3.1	3.0	1.3
Locomotion velocity, hab. session 2	5.5	7.4	9.6	2.9	-2.9	3.1	3.0	1.6
Novel to familiar place preference ratio	1.4	1.8	3.3	1.2	-1.2	1.7	1.8	-0.1
Novelty place preference	1.0	1.3	2.5	1.0	-1.0	1.5	1.6	-0.1
Time in novel zone, NPP test	1.4	1.7	3.0	1.2	-1.2	1.6	1.7	-0.1
Total zone transitions, NPP test	3.2	4.8	6.6	2.2	-2.2	2.6	2.4	1.6
Total locomotion distance, NPP test	6.6	9.2	12.4	3.0	-3.0	3.5	3.4	1.9
Locomotion velocity, NPP test	5.6	8.0	10.8	2.8	-2.8	3.3	3.2	1.8
Intraocular pressure	0.3	0.5	1.3	0.2	-0.2	0.9	1.1	0.7
Delta distance traveled before/after self-admin	1.7	1.9	3.7	1.1	-1.1	1.7	1.9	0.1
Delta ambulatory time before/after self-admin	1.2	2.1	4.2	1.2	-1.2	1.8	2.1	0.0
Parametrial fat weight	0.0	0.0	0.1	-0.3	0.3	0.1	0.2	0.1
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.3	-0.3	0.6	0.7	0.0
Pavlov. Cond. magazine entry latency	2.1	2.8	4.1	-1.5	1.5	-2.0	-2.0	-1.2
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	0.4	-0.4	0.6	0.7	-0.8
Pavlov. Cond. index score	1.1	1.4	2.0	-1.1	1.1	-1.4	-1.4	-0.8
Pavlov. Cond. latency score	1.3	1.7	2.7	-1.2	1.2	-1.6	-1.7	-0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.3	0.0
Pavlov. Cond. magazine entry number	2.6	3.2	3.9	1.7	-1.7	2.0	2.0	1.5
Pavlov. Cond. intertrial magazine entries	2.0	2.4	2.7	1.6	-1.6	1.7	1.6	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	0.9	1.3	-0.9	0.9	-1.1	-1.1	-0.9
Pavlov. Cond. response bias	1.4	1.7	2.0	-1.3	1.3	-1.4	-1.4	-1.2
Pavlov. Cond. lever latency	0.4	0.6	1.0	-0.7	0.7	-1.0	-1.0	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	-0.0	0.0	0.7	0.9	-0.5
Pavlov. Cond. change in total contacts	0.4	1.0	2.1	0.8	-0.8	1.3	1.4	-0.1
Pavlov. Cond. index score	0.3	0.5	1.2	0.4	-0.4	1.0	1.1	0.0
Pavlov. Cond. latency score	0.2	0.2	0.7	0.2	-0.2	0.7	0.8	-0.1
Pavlov. Cond. lever contacts	0.8	1.2	1.8	1.0	-1.0	1.3	1.3	0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.9	-0.2	0.2	-0.8	-0.9	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.8	0.5	-0.5	0.1	-0.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	0.4	-0.4	0.9	1.1	0.0
Pavlov. Cond. response bias	0.8	1.1	2.1	0.8	-0.8	1.4	1.5	0.5
Time in closed arm before self-admin	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.0	-0.1
Time in closed arm after self-admin	1.0	1.1	1.6	-1.2	1.2	-0.8	-0.6	-1.3
Time in open arm before self-admin	0.0	0.1	0.2	-0.1	0.1	-0.2	-0.3	-0.4
Time in open arm after self-admin	0.7	0.8	0.9	1.0	-1.0	0.9	0.9	0.6
Bone: periosteal estimation	3.1	7.3	10.0	-3.2	3.2	-2.4	-1.9	-2.6
Bone: periosteal perimeter	7.0	13.7	17.7	-4.2	4.2	-3.7	-3.3	-2.9
Bone: post-yield work	0.3	0.6	1.2	0.1	-0.1	0.8	1.0	-1.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.6	0.1	-0.1	0.6	0.8	-0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.6	0.0	-0.0	0.6	0.7	-0.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.1	-0.3
Progressive ratio test 2 active lever presses	0.4	0.6	1.1	0.2	-0.2	0.9	1.1	-0.9
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	0.2	-0.2	0.8	0.9	-0.9
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	0.2	0.0	0.1	-0.3
Incentive Sensitization - Responses	0.2	0.5	1.1	-0.7	0.7	-0.4	-0.3	-1.1
Incentive Sensitization - Breakpoint	0.3	0.6	1.3	-0.8	0.8	-0.6	-0.4	-1.1
Sum of active levers in priming session hrs 5-6	0.6	0.5	1.7	-0.6	0.6	-0.0	0.3	-1.3
Progressive ratio	0.2	0.6	2.0	-0.5	0.5	0.2	0.5	-1.4
Food seeking constrained by brief footshock	1.0	1.2	1.9	-1.1	1.1	-1.0	-0.9	-1.4
Seeking ratio, punishment vs. effort	0.1	0.3	0.7	-0.2	0.2	-0.7	-0.8	0.5
Retroperitoneal fat weight	0.0	0.1	0.3	-0.2	0.2	0.0	0.0	0.5
Reaction time number correct	1.2	4.3	4.5	2.1	-2.1	2.1	1.9	2.1
Reaction time mean minus median	0.1	0.4	0.6	-0.8	0.8	-0.7	-0.7	-0.2
Reaction time mean minus median AUC	0.1	0.9	1.7	-0.9	0.9	-1.2	-1.3	-0.2
Reaction time num false alarms	0.0	0.0	0.1	0.0	-0.0	0.1	0.1	-0.3
Reaction time num false alarms AUC	0.0	0.1	0.2	0.2	-0.2	0.4	0.4	-0.4
Reaction time trials correct on left	1.2	4.3	4.5	2.1	-2.1	2.1	1.9	2.1
Reaction time trials on left	1.2	4.2	4.4	2.1	-2.1	2.1	1.9	2.1
Reaction time mean	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1	-0.2
Reaction time mean AUC	0.0	0.0	0.1	-0.0	0.0	0.2	0.3	-0.2
Median of all reaction times	0.0	0.0	0.1	0.0	-0.0	0.0	0.2	-0.3
Reaction time omissions	0.9	1.5	1.9	-1.4	1.4	-1.3	-1.3	0.3
Reaction time false alarm rate	0.6	0.8	2.0	-0.8	0.8	-0.7	-0.6	-1.4
Reaction time premature initiation rate	2.3	3.6	5.8	1.8	-1.8	2.3	2.4	0.0
Reaction time premature initiations	2.4	7.3	10.6	2.7	-2.7	3.2	3.3	0.9
Std. dev. reaction times	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.1	-0.0
Reaction time trials completed	1.2	4.2	4.4	2.1	-2.1	2.1	1.9	2.1
Reaction time trials AUC	1.4	5.0	5.3	2.3	-2.3	2.3	2.1	2.1
Run reversals in cocaine runway, females	0.4	0.4	1.3	-0.3	0.3	-0.5	-0.5	1.1
Run reversals in cocaine runway, males	0.2	0.3	1.1	-0.3	0.3	0.1	0.3	-1.0
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.2	-0.2	0.6	0.7	-0.6
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	0.7	-0.7	0.8	0.8	-0.0
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	-0.3	0.3	0.4	0.6	-0.8
Std. dev. time between licks in bursts	1.1	2.1	2.7	1.6	-1.6	1.4	1.2	1.3
Total sessions with >9 infusions	2.2	2.8	6.0	-1.9	1.9	-0.7	-0.3	-2.4
Short access day 1 total inactive lever presses	1.3	2.5	3.3	-1.8	1.8	-1.3	-1.1	-1.7
Short access day 10 total inactive lever presses	0.1	0.7	1.7	-0.5	0.5	-1.1	-1.3	-0.1
Short access day 1 total infusions	1.2	2.3	4.2	-1.8	1.8	-0.8	-0.4	-2.0
Short access day 10 total infusions	1.8	3.0	5.9	-2.0	2.0	-0.9	-0.5	-2.4
Short access total infusions	1.2	1.7	4.4	-1.4	1.4	-0.4	-0.0	-2.1
Short access day 1 locomotion	0.7	1.2	2.7	-1.3	1.3	-0.4	-0.2	-1.6
Short access day 10 total locomotion	0.3	1.2	2.2	-1.3	1.3	-0.7	-0.5	-1.5
Short access total locomotion	1.9	2.9	5.9	-1.9	1.9	-1.0	-0.7	-2.4
One hour access (0.3 mA shock)	0.3	0.4	1.2	0.3	-0.3	0.8	1.1	-0.2
Compulsive drug intake	0.3	0.5	0.6	0.7	-0.7	0.7	0.7	0.7
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	0.0	0.2	-0.0
Social response proportion	0.4	0.5	1.1	0.5	-0.5	0.6	0.6	1.0
Social responses	0.4	0.5	1.9	0.5	-0.5	0.3	0.2	1.4
Social time	0.2	0.3	0.5	0.5	-0.5	0.6	0.5	0.7
Soleus weight	0.6	1.8	3.2	1.2	-1.2	1.2	1.1	1.8
Bone: stiffness	1.4	2.5	3.6	-1.7	1.7	-1.4	-1.2	-1.9
Tibialis anterior weight	0.1	0.5	0.9	0.4	-0.4	0.8	0.9	0.8
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.6	0.8	-0.8	0.5	0.4	0.7
Time to tail flick, vehicle, after self-admin	0.8	1.6	2.0	-1.4	1.4	-1.2	-1.2	-1.1
Time to tail flick, test, before self-admin	1.0	1.2	1.7	1.3	-1.3	0.8	0.6	1.2
Time to tail flick, test, after self-admin	1.7	1.8	2.4	-1.4	1.4	-1.6	-1.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	1.1	-1.0	1.0	-0.8	-0.9	-0.9
Delta time to tail flick, test, before/after SA	2.5	3.1	3.8	-2.0	2.0	-1.9	-1.7	-1.2
Tibia length	11.0	30.7	41.8	-5.8	5.8	-6.5	-6.3	-2.1
Ambulatory time before self-admin	0.3	0.9	2.1	-0.5	0.5	-1.2	-1.4	0.4
Ambulatory time after self-admin	0.3	0.5	0.9	0.6	-0.6	1.0	1.0	-0.1
Bone: tissue strength	0.7	0.7	2.2	-0.0	0.0	0.8	0.9	-1.5
Total heroin consumption	3.1	3.6	4.8	-2.2	2.2	-1.6	-1.4	-2.0
Bone: trabecular number	0.2	0.3	0.5	0.7	-0.7	0.5	0.5	-0.3
Bone: trabecular spacing	0.2	0.3	0.6	-0.5	0.5	-0.4	-0.5	0.8
Bone: trabecular thickness	0.2	0.3	0.6	0.3	-0.3	0.6	0.8	-0.8
Bone: trabecular tissue density	0.3	0.5	2.0	-0.2	0.2	-0.3	-0.6	1.4
Water consumed over 24 hours	0.3	0.6	1.7	0.7	-0.7	0.5	0.3	1.3
Number of responses in last shaping day	1.8	2.4	3.3	-1.8	1.8	-1.2	-1.0	-1.8