Tnnt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	NM_134388.2	0.02	0.02	4.9e-03	0.02	0.01	0.02	0.01	9.1e-03	1.5e-02	9.6e-03	3.3e-02
2	NAcc	intron excision ratio	chr1_78350613_78350777	0.02	0.02	4.2e-04	0.02	0.02	0.01	0.01	2.9e-04	1.1e-03	7.1e-03	2.5e-03
3	NAcc	gene expression	Tnnt1	0.12	0.08	0.0e+00	0.12	0.12	0.12	0.12	5.9e-18	5.4e-18	1.3e-17	1.1e-17
4	Brain	gene expression	Tnnt1	0.25	0.12	0.0e+00	0.28	0.33	0.33	0.33	8.1e-26	3.4e-31	2.8e-31	1.4e-31
5	Brain	alternative TSS	XM_063276629.1	0.03	0.02	4.2e-04	0.02	0.01	0.07	0.01	8.7e-03	1.7e-02	1.6e-07	2.9e-02
6	Brain	intron excision ratio	chr1_78349079_78350777	0.03	0.03	9.4e-03	-0	0	0.01	-0	8.1e-01	1.6e-01	5.9e-02	7.9e-01
7	Adipose	gene expression	Tnnt1	0.17	0.12	7.3e-09	0.06	0.07	0.08	0.06	3.6e-07	6.6e-08	8.1e-09	1.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.5	0.4	-0.0	0.3
Area under the delay curve	0.3	0.4	1.2	-0.6	0.6	0.6	0.7	-0.4	1.1	0.1
BMI with tail	0.4	1.4	2.2	-1.3	1.3	1.4	1.5	-1.5	0.8	-0.3
BMI without tail	0.0	0.2	0.4	0.4	-0.5	-0.4	-0.5	0.2	-0.6	-0.6
Body weight	1.0	4.5	6.9	2.6	-2.5	-2.4	-2.2	1.6	-1.8	-1.1
Weight adjusted by age	0.2	0.7	1.4	0.8	-0.8	-0.9	-0.8	1.2	0.1	0.9
Bone surface	2.3	4.6	6.4	2.5	-2.5	-2.4	-2.4	2.1	-1.8	-0.5
Bone volume	1.8	3.5	5.0	2.2	-2.1	-2.1	-2.2	1.9	-1.4	-0.2
Breakpoint value in progressive ratio session	0.3	0.5	0.9	-0.6	0.7	0.7	0.8	-1.0	-0.8	-0.1
Number of licking bursts	0.0	0.0	0.1	-0.3	0.3	0.3	0.2	-0.2	-0.1	-0.0
Context. condit. distance diff. score	0.1	0.2	0.5	-0.4	0.4	0.3	0.3	-0.3	-0.4	0.7
Locomotion velocity, session 1	1.2	1.4	7.1	-0.4	0.4	0.2	0.0	0.8	1.2	2.7
Locomotion distance, session 1	1.8	2.3	3.8	1.4	-1.4	-1.6	-1.7	2.0	-0.9	1.6
Locomotion velocity, session 2	0.4	0.5	2.3	-0.5	0.6	0.4	0.2	0.2	0.8	1.5
Locomotion distance, session 2	1.4	2.0	3.8	1.4	-1.5	-1.5	-1.7	2.0	-0.0	1.0
Locomotion velocity, session 3	0.1	0.1	0.2	-0.3	0.3	0.3	0.2	-0.1	0.0	0.5
Locomotion distance, session 3	0.2	0.2	0.7	0.3	-0.3	-0.4	-0.4	0.6	-0.4	0.8
Stereotopy head waving bouts, day 3	0.2	0.3	0.8	-0.3	0.3	0.3	0.4	-0.7	-0.9	-0.4
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.3	0.3	0.3	0.4	-0.6	-0.7	-0.4
Locomotion velocity, session 7	0.1	0.2	0.6	-0.0	-0.1	-0.1	-0.1	0.2	-0.6	0.8
Locomotion distance, session 7	0.2	0.3	1.6	-0.2	0.1	-0.0	0.1	0.3	0.4	1.3
Stereotopy head waving bouts, day 7	0.5	0.6	2.6	0.5	-0.5	-0.4	-0.5	-0.0	-1.6	-0.8
Stereotopy head waving duration, day 7	0.4	0.4	1.7	0.6	-0.5	-0.4	-0.5	0.1	-1.3	-0.7
Locomotion velocity, session 8	0.3	0.3	1.6	-0.4	0.3	0.2	-0.0	0.2	-0.6	1.3
Locomotion distance, session 8	0.2	0.3	1.3	0.2	-0.3	-0.4	-0.4	0.6	-0.3	1.2
Degree of sensitization distance	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.0	0.0	-0.1	0.2
Degree of sensitization stereotypy	0.2	0.3	1.0	0.3	-0.2	-0.2	-0.2	-0.2	-1.0	-0.8
Conditioned locomotion	0.2	0.2	1.0	0.0	0.0	-0.1	0.0	0.1	-0.7	1.0
Cocaine response after cond. corrected	1.2	1.8	2.1	-1.3	1.3	1.4	1.3	-1.4	1.3	-1.4
Cocaine response after cond. not corrected	0.2	0.3	1.3	0.3	-0.3	-0.2	-0.4	0.2	0.6	-1.2
Cocaine response before conditioning	6.0	7.3	10.0	3.1	-3.1	-3.1	-3.2	3.1	-1.7	0.4
Saline control response	0.3	0.5	2.6	-0.1	0.2	-0.0	-0.2	0.4	-0.7	1.6
Bone: connectivity density	0.0	0.1	0.2	-0.2	0.3	0.2	0.1	-0.1	0.4	0.0
Bone: cortical apparent density	0.6	0.9	3.7	-0.0	0.0	-0.1	-0.2	0.8	1.9	1.4
Bone: cortical area	0.7	1.2	1.9	1.3	-1.3	-1.2	-1.0	0.8	-1.4	-0.3
Bone: cortical porosity	0.8	0.8	1.9	-0.7	0.8	0.8	0.7	-1.2	-1.4	-0.6
Bone: cortical porosity	0.8	0.9	3.9	-0.2	0.3	0.4	0.3	-0.9	-2.0	-1.1
Bone: cortical thickness	0.3	0.5	0.8	-0.9	0.8	0.8	0.9	-0.7	-0.0	0.5
Bone: cortical thickness	0.3	0.4	1.1	0.2	-0.2	-0.3	-0.3	0.7	1.0	0.8
Bone: cortical tissue density	0.6	0.9	3.8	-0.0	0.0	-0.1	-0.2	0.8	1.9	1.3
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.5	0.5	0.5	0.5	-0.7	-0.6	-0.3
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.3	-1.3	1.4	1.4	1.5	-1.5	0.3	-0.4
Condit. Reinf. active responses	0.3	0.3	1.8	0.3	-0.3	-0.3	-0.4	0.1	-1.3	-0.3
Condit. Reinf. inactive responses	2.6	3.4	4.6	1.9	-2.0	-2.0	-2.1	1.9	-2.0	0.2
Incentive salience index mean	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.2	0.1	-0.4	-0.1
Condit. Reinf. lever presses	0.5	0.8	1.3	1.0	-1.0	-1.1	-0.9	1.1	0.3	0.2
Condit. Reinf. active minus inactive responses	2.8	4.4	5.8	2.4	-2.4	-2.4	-2.2	2.0	-2.0	0.1
Condit. Reinf. active-inactive response ratio	3.5	5.6	8.0	2.8	-2.8	-2.7	-2.6	2.3	-1.8	-0.6
Condit. Reinf. active responses	2.8	4.0	5.9	2.2	-2.1	-2.2	-2.1	1.9	-2.4	0.5
Condit. Reinf. inactive responses	0.2	0.4	2.4	0.0	-0.0	-0.1	-0.1	-0.0	-1.6	0.4
Condit. Reinf. lever presses	1.2	1.7	5.2	1.1	-1.1	-1.0	-0.9	0.2	-2.3	-1.5
Condit. Reinf. lever reinforcers received	3.6	5.0	6.8	2.4	-2.4	-2.5	-2.3	2.1	-2.6	0.5
Conditioned reinforcement - actives	0.2	0.7	2.7	0.8	-0.6	-0.5	-0.6	0.8	1.6	-0.2
Conditioned reinforcement - inactives	1.1	2.9	5.0	1.8	-1.9	-1.9	-1.9	2.2	0.9	0.6
Conditioned locomotion	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.4	0.4	0.6	-0.3
Patch foraging indifference point 0 sec	0.3	0.8	1.7	-0.8	1.0	0.8	0.7	-0.3	0.9	1.3
Patch foraging indifference point AUC	0.3	0.7	1.1	-1.0	0.9	1.0	0.9	-1.0	0.4	-0.1
Delay disc. indifference point, 0s delay	0.3	0.4	1.9	-0.3	0.3	0.0	0.2	0.4	0.6	1.4
Delay disc. indifference point, 16s delay	0.6	0.8	1.9	-0.6	0.6	0.9	0.8	-1.2	-0.1	-1.4
Delay disc. indifference point, 2s delay	1.2	1.4	6.6	-0.8	0.9	0.7	0.7	-0.1	2.6	0.8
Delay disc. indifference point, 24s delay	0.3	0.5	0.9	-0.7	0.7	0.9	0.7	-1.0	0.1	-0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.8	0.4	-0.3	-0.3	-0.2	0.4	0.9	-0.2
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	-0.3	0.3	0.3	0.4	-0.1	0.7	0.3
Indifference point function ln k	2.1	6.4	8.7	2.9	-2.8	-2.9	-2.8	2.9	-1.7	1.0
Indifference point function log k	2.1	6.4	8.7	2.9	-2.8	-2.9	-2.8	2.9	-1.7	1.0
Patch foraging total patch changes 0 sec	0.2	0.7	1.6	-0.8	0.9	0.7	0.7	-0.3	0.8	1.3
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	-0.6	0.6	0.6	0.5	-0.5	0.4	-0.1
Patch foraging total patch changes 18 sec	0.3	0.7	1.0	-0.9	1.0	1.0	0.9	-0.7	1.0	0.3
Patch foraging total patch changes 24 sec	0.0	0.1	0.9	0.0	-0.1	-0.0	-0.2	-0.2	-0.3	-0.9
Patch foraging total patch changes 6 sec	0.6	1.1	1.6	-1.2	1.2	1.2	1.1	-1.0	0.8	0.2
Patch foraging time to switch 0 sec	1.0	3.8	9.2	-1.5	1.5	1.9	1.7	-2.4	1.0	-3.0
Patch foraging water rate 0 sec	0.3	1.0	2.6	0.7	-0.7	-0.9	-0.8	1.1	-0.5	1.6
Patch foraging water rate 12 sec	0.7	3.0	5.0	1.6	-1.6	-1.8	-1.8	2.2	-0.8	1.8
Patch foraging water rate 18 sec	0.5	1.2	1.8	0.9	-1.0	-1.2	-1.0	1.3	-0.9	1.4
Patch foraging water rate 24 sec	0.7	1.0	1.5	1.0	-1.0	-1.1	-1.0	1.2	-0.6	1.0
Patch foraging water rate 6 sec	4.8	7.0	9.6	3.0	-3.1	-3.1	-3.1	2.8	-1.9	-0.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	2.5	-0.0	0.1	-0.2	0.1	0.3	-0.6	1.6
Distance traveled before self-admin	1.0	2.1	5.3	1.0	-1.1	-1.5	-1.2	1.9	-0.5	2.3
Distance traveled after self-admin	0.6	1.0	2.5	-0.8	0.8	0.5	0.8	-0.5	-1.4	1.6
Extensor digitorum longus weight	0.2	0.8	1.3	1.2	-1.1	-1.0	-0.8	0.5	-0.9	-0.8
Bone: elastic displacement	0.5	0.7	1.7	-0.7	0.7	0.7	0.8	-0.9	-1.3	0.5
Bone: elastic work	0.4	0.5	0.6	0.8	-0.8	-0.8	-0.7	0.8	-0.3	0.6
Bone: endosteal estimation	2.2	5.4	8.3	2.9	-2.9	-2.8	-2.6	2.3	-1.1	-0.8
Bone: endosteal perimeter	1.4	3.4	5.1	2.2	-2.2	-2.2	-1.9	1.7	-1.4	-0.5
Epididymis fat weight	0.1	0.7	4.2	0.3	-0.4	-0.0	0.1	-0.7	-0.4	-2.0
Delta time in closed arm before/after self-admin	0.4	0.4	2.0	-0.4	0.3	0.3	0.1	0.2	1.4	0.3
Delta time in open arm before/after self-admin	1.5	1.8	5.0	1.3	-1.2	-1.3	-1.2	1.0	-2.2	0.4
Diff in mean of infusions in LGA sessions	0.2	0.4	1.2	0.1	0.0	-0.1	-0.0	0.6	1.1	1.1
Delay discount exponential model param	0.2	0.3	1.0	0.4	-0.5	-0.5	-0.6	0.3	-1.0	-0.1
Extinction: sum of active levers before priming	0.2	0.3	1.0	-0.5	0.3	0.3	0.4	-0.4	-1.0	0.4
Active lever presses in extinction session 6	0.5	0.5	2.5	0.1	0.0	0.2	0.1	-0.8	-0.7	-1.6
Bone: final force	1.8	3.0	4.3	2.1	-2.1	-2.0	-1.9	2.1	0.3	0.1
Bone: final moment	2.3	3.8	5.6	2.3	-2.3	-2.3	-2.2	2.4	0.3	0.3
Food consumed during 24 hour testing period	1.0	2.1	3.1	1.7	-1.6	-1.6	-1.8	1.6	-0.6	0.0
Glucose	1.5	2.4	3.3	-1.8	1.8	1.7	1.8	-1.4	1.2	1.0
Heart weight	1.2	2.0	2.7	1.6	-1.6	-1.5	-1.6	1.2	-1.2	-1.0
Delay discount hyperbolic model param	0.4	0.5	1.8	0.5	-0.6	-0.6	-0.7	0.3	-1.3	-0.2
Intermittent access intake day 1-15 change	0.1	0.7	1.3	1.1	-1.1	-1.1	-0.9	0.8	-0.3	-0.0
Intermittent access intake escalation	0.2	1.2	2.1	1.4	-1.5	-1.4	-1.2	1.0	-0.5	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.4	0.3	-0.3	-0.4	-0.2	0.4	-0.3	0.6
Intermitt. access day 1 inactive lever presses	0.1	1.7	2.7	1.5	-1.6	-1.5	-1.5	1.2	-0.8	-0.7
Intermitt. access day 15 inactive lever presses	0.6	3.1	4.6	2.1	-2.1	-1.9	-2.1	1.7	-1.4	-0.7
Intermitt. access escalation Index	0.2	0.5	0.8	-0.7	0.7	0.7	0.9	-0.7	0.6	0.4
Intermittent access day 1 total infusions	0.2	0.6	0.9	1.0	-0.9	-0.8	-0.8	0.8	0.8	-0.3
Intermittent access day 15 total infusions	0.5	1.2	1.9	1.4	-1.4	-1.2	-1.1	1.0	0.6	-0.6
Intermittent access terminal intake (last 3 days)	0.6	1.1	1.6	1.2	-1.3	-1.2	-1.0	1.0	0.9	-0.4
Intermittent access total infusions	1.4	1.6	2.3	1.5	-1.5	-1.4	-1.3	1.4	1.1	-0.3
Intermittent access day 1 locomotion	0.8	1.5	2.0	1.4	-1.3	-1.3	-1.2	1.4	1.1	-0.0
Intermittent access day 15 total locomotion	0.5	1.8	2.7	1.5	-1.4	-1.5	-1.1	1.6	1.0	1.0
Intermittent access total locomotion	2.7	3.2	5.0	2.2	-2.1	-2.1	-1.9	2.1	0.8	0.3
Intermittent access standard deviation	0.1	0.3	0.8	-0.5	0.5	0.5	0.7	-0.5	0.9	0.3
Left kidney weight	2.6	20.9	29.9	5.5	-5.4	-5.3	-5.0	4.3	-3.7	-1.0
Right kidney weight	3.0	20.9	29.3	5.4	-5.3	-5.2	-5.1	4.2	-4.0	-1.7
Cocaine induced anxiety	0.5	1.4	4.1	1.2	-1.1	-1.1	-1.2	0.8	-2.0	-0.2
Post-drug Anxiety	1.1	1.3	5.4	0.8	-0.9	-0.7	-0.8	0.1	-2.3	-1.1
Baseline Anxiety	0.4	0.7	0.9	-0.9	0.8	0.9	0.9	-0.9	0.8	-0.3
Tail length	2.0	10.8	14.6	3.8	-3.8	-3.8	-3.8	3.3	-2.6	-0.7
Length with tail	2.6	11.7	17.2	4.2	-4.1	-3.9	-3.8	3.0	-2.7	-1.5
Length without tail	0.9	4.5	7.1	2.7	-2.5	-2.3	-2.1	1.3	-1.6	-2.1
Times rat made contact with spout	0.1	0.1	0.4	-0.1	0.2	0.2	0.1	-0.3	-0.0	-0.6
Lifetime Intake	1.0	1.3	1.7	1.3	-1.2	-1.1	-1.1	1.3	1.3	-0.2
Liver weight, left	0.9	1.6	2.5	1.6	-1.4	-1.4	-1.4	1.2	-0.9	-0.5
Liver weight, right	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.0	-0.1	-0.2
Locomotor activity	0.1	0.1	0.3	-0.1	0.2	0.3	0.2	-0.3	0.3	-0.6
Locomotor testing distance	0.1	0.2	1.1	0.3	-0.3	-0.1	-0.3	-0.0	-0.1	-1.1
Locomotor testing rearing	0.2	0.7	1.0	1.0	-0.9	-0.9	-0.9	0.7	-0.7	-0.6
Locomotion in novel chamber	1.1	1.5	2.2	-1.2	1.5	1.3	1.5	-1.1	1.3	0.5
Locomotion in novel chamber post-restriction	0.4	1.1	3.9	-0.8	0.9	0.9	0.9	-0.6	2.0	0.1
Fecal boli incidents, locomotor time 1	0.1	0.3	0.5	0.6	-0.6	-0.6	-0.5	0.7	0.4	0.3
Change in fecal boli incidents, locomotor task	2.7	2.8	3.8	-1.9	1.9	1.8	1.8	-1.4	1.9	0.7
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.2	0.1	0.2	0.1	-0.2	0.2	-0.2
Bouts of movement, locomotor time 1	0.5	0.7	3.3	0.1	-0.3	-0.6	-0.3	0.9	-0.2	1.8
Total resting periods, locomotor time 1	0.3	0.3	1.8	-0.2	0.1	-0.1	0.2	0.3	0.3	1.4
Rest time, locomotor task time 1	0.8	1.2	1.9	1.3	-1.4	-1.3	-1.2	1.3	0.2	-0.1
Distance moved, locomotor task time 1	0.5	1.4	2.1	-1.3	1.4	1.4	1.4	-1.5	-0.5	0.1
Vertical activity count, locomotor time 1	0.4	3.0	4.6	-2.0	2.2	1.9	2.1	-1.6	0.6	1.3
Time >=10cm from walls, locomotor time 2	0.3	0.7	1.1	-1.0	0.9	1.0	0.9	-1.0	0.5	-0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.1	0.1	-0.0
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.1	-0.2	-0.2	-0.1	0.3	0.4	0.2
Rest time, locomotor task time 2	0.1	0.2	0.7	-0.0	-0.0	-0.1	-0.0	0.4	0.5	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.4	-0.5	0.5	0.5	0.4	-0.6	-0.6	-0.1
Vertical activity count, locomotor time 2	0.1	0.2	0.4	-0.4	0.5	0.4	0.6	-0.4	0.3	0.4
Light reinforcement 1	0.2	0.7	3.9	-0.5	0.6	0.3	0.2	0.3	0.6	2.0
Light reinforcement 2	0.9	2.1	2.8	-1.7	1.7	1.5	1.6	-1.2	1.2	1.2
Bone: marrow area	2.2	5.4	8.4	2.9	-2.9	-2.8	-2.6	2.3	-1.1	-0.9
Bone: maximum diameter	0.9	1.9	2.6	1.6	-1.6	-1.5	-1.3	0.9	-1.4	-1.0
Bone: maximum force	2.3	4.6	7.0	2.6	-2.6	-2.6	-2.4	2.3	-0.6	-0.4
Bone: maximum moment	2.8	5.2	7.8	2.8	-2.8	-2.7	-2.6	2.6	-0.5	-0.1
Mean time between licks in bursts	0.1	0.8	1.2	-1.0	1.0	0.9	0.8	-0.5	0.8	1.1
Mean num. licks in bursts	0.1	0.1	0.3	0.5	-0.4	-0.4	-0.3	0.2	0.2	-0.5
Cd content in liver	1.8	2.0	2.8	1.6	-1.6	-1.6	-1.7	1.6	-0.8	0.2
Co content in liver	1.3	1.5	3.3	0.7	-0.7	-0.9	-1.1	1.7	1.3	1.8
Cu content in liver	0.7	0.9	1.6	1.1	-1.0	-1.0	-1.2	1.2	-0.1	-0.1
Fe content in liver	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.6	0.6	-0.2	0.1
K content in liver	0.1	0.1	0.3	-0.1	0.1	0.1	-0.3	0.0	-0.6	-0.1
Mg content in liver	0.2	0.2	0.6	-0.2	0.3	0.3	0.1	-0.5	-0.3	-0.8
Mn content in liver	0.5	0.6	2.8	-0.0	0.1	0.2	0.1	-0.6	-1.7	-0.9
Na content in liver	2.2	2.5	4.1	-2.0	2.0	2.0	1.6	-1.8	-0.1	0.1
Rb content in liver	2.6	3.0	4.5	1.9	-1.8	-1.8	-1.9	1.3	-2.1	-1.1
Se content in liver	1.9	2.3	4.6	-1.5	1.5	1.6	1.8	-2.1	-0.4	-0.9
Sr content in liver	6.0	5.2	7.0	-2.6	2.6	2.4	2.5	-1.6	2.2	1.8
Zn content in liver	0.5	0.6	1.5	-0.5	0.6	0.7	0.5	-0.8	0.7	-1.2
Bone: minimum diameter	2.8	5.4	7.2	2.7	-2.7	-2.7	-2.6	2.2	-2.1	-0.4
Time in familiar zone, hab. session 1	2.9	3.2	5.5	1.8	-1.8	-1.9	-1.8	2.3	0.7	1.8
Time in novel zone, hab. session 1	2.2	2.4	3.9	-1.7	1.8	1.8	1.6	-2.0	-0.6	-0.7
Total zone transitions, hab. session 1	0.8	1.2	4.2	0.6	-0.5	-0.8	-0.8	1.4	0.2	2.1
Total locomotion distance, hab. session 1	0.4	0.6	3.1	0.2	-0.2	-0.4	-0.3	0.9	0.4	1.8
Locomotion velocity, hab. session 1	0.3	0.4	1.9	0.1	-0.1	-0.3	-0.3	0.8	0.4	1.4
Time in familiar zone, hab. session 2	2.5	2.9	4.2	2.0	-2.0	-1.9	-2.0	1.6	-0.6	-1.1
Time in novel zone, hab. session 2	1.6	1.8	2.6	-1.6	1.6	1.5	1.6	-1.5	0.2	0.5
Total zone transitions, hab. session 2	1.8	2.3	3.1	1.6	-1.5	-1.7	-1.7	1.7	-1.4	0.9
Total locomotion distance, hab. session 2	0.2	0.2	1.4	-0.0	0.0	-0.1	-0.0	0.4	0.1	1.2
Locomotion velocity, hab. session 2	0.2	0.3	1.7	-0.2	0.2	0.0	0.1	0.3	0.2	1.3
Novel to familiar place preference ratio	0.1	0.1	0.3	0.2	-0.2	-0.1	-0.1	-0.1	-0.6	-0.4
Novelty place preference	0.1	0.2	0.4	0.4	-0.4	-0.4	-0.3	0.2	-0.7	-0.2
Time in novel zone, NPP test	0.1	0.2	0.4	0.5	-0.5	-0.4	-0.3	0.2	-0.6	-0.3
Total zone transitions, NPP test	0.3	0.4	1.0	0.5	-0.5	-0.6	-0.8	1.0	0.2	0.8
Total locomotion distance, NPP test	0.2	0.3	0.5	0.6	-0.6	-0.6	-0.7	0.6	-0.6	-0.0
Locomotion velocity, NPP test	0.3	0.4	0.5	0.6	-0.6	-0.7	-0.7	0.7	-0.7	0.3
Intraocular pressure	0.0	0.1	0.2	-0.3	0.3	0.2	0.1	-0.0	0.3	0.4
Delta distance traveled before/after self-admin	1.7	1.9	3.2	-1.5	1.6	1.6	1.6	-1.8	-0.3	-0.4
Delta ambulatory time before/after self-admin	0.8	1.3	2.0	-1.3	1.4	1.4	1.3	-1.4	0.1	-0.1
Parametrial fat weight	1.4	3.2	4.7	-2.0	2.0	2.1	2.2	-2.1	1.2	-0.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.5	0.4	0.4	0.3	-0.3	-0.1	0.5
Pavlov. Cond. magazine entry latency	0.6	0.7	1.0	-0.9	0.9	0.9	0.9	-1.0	0.6	-0.8
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	-0.5	0.6	0.5	0.5	-0.3	0.8	0.1
Pavlov. Cond. index score	0.2	0.3	0.5	-0.5	0.6	0.6	0.6	-0.5	0.7	-0.3
Pavlov. Cond. latency score	0.2	0.2	0.5	-0.4	0.4	0.5	0.5	-0.4	0.7	-0.4
Pavlov. Cond. lever contacts	0.2	0.3	1.0	0.5	-0.5	-0.4	-0.4	0.1	-0.2	-1.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.5	-0.5	-0.5	-0.5	0.5	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.6	3.2	-0.3	0.4	0.2	0.1	0.2	-0.6	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	-0.5	0.6	0.6	0.6	-0.6	0.6	-0.3
Pavlov. Cond. response bias	0.1	0.2	1.0	0.0	0.0	0.1	0.0	-0.2	0.2	-1.0
Pavlov. Cond. lever latency	0.4	0.5	1.1	0.6	-0.6	-0.6	-0.8	1.0	1.1	0.1
Pavlov. Cond. magazine entry latency	0.7	0.9	2.0	-0.9	0.9	1.0	1.2	-1.4	-0.4	-0.5
Pavlov. Cond. change in total contacts	0.2	0.5	2.8	0.4	-0.3	-0.4	-0.2	0.1	-1.7	0.5
Pavlov. Cond. index score	0.2	0.4	1.6	-0.2	0.2	0.3	0.4	-0.7	-1.3	-0.3
Pavlov. Cond. latency score	0.4	0.6	1.3	-0.6	0.7	0.7	0.8	-1.1	-1.0	-0.3
Pavlov. Cond. lever contacts	0.3	0.4	1.8	-0.2	0.3	0.3	0.4	-0.7	-1.3	-0.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	0.7	-0.7	-0.8	-0.9	1.0	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	1.8	3.8	5.3	2.2	-2.3	-2.3	-2.3	2.1	-1.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.0	-0.3	0.4	0.4	0.5	-0.8	-1.0	-0.1
Pavlov. Cond. response bias	0.3	0.4	2.4	0.4	-0.4	-0.4	-0.2	-0.1	-1.6	-0.3
Time in closed arm before self-admin	0.5	0.9	1.5	1.2	-1.0	-1.0	-1.0	0.8	-1.0	-0.2
Time in closed arm after self-admin	0.2	0.2	0.4	0.5	-0.3	-0.2	-0.4	0.3	0.5	-0.6
Time in open arm before self-admin	1.9	2.3	3.4	-1.8	1.7	1.6	1.5	-1.2	1.8	0.3
Time in open arm after self-admin	0.3	0.3	0.5	-0.6	0.6	0.4	0.6	-0.5	-0.6	0.7
Bone: periosteal estimation	1.7	4.0	6.0	2.5	-2.4	-2.4	-2.1	1.9	-1.4	-0.6
Bone: periosteal perimeter	1.3	2.6	3.8	2.0	-2.0	-1.9	-1.6	1.5	-1.5	-0.2
Bone: post-yield work	2.4	4.2	5.9	2.4	-2.4	-2.3	-2.3	1.7	-1.6	-1.2
Progressive ratio test 1 active lever presses	0.5	0.9	1.6	0.9	-0.8	-0.9	-0.8	1.3	0.8	1.0
Progressive ratio test 1 breakpoint	0.5	0.9	1.6	0.9	-0.8	-0.9	-0.8	1.3	0.9	1.0
Progressive ratio test 1 inactive lever presses	1.2	3.2	5.4	2.0	-2.0	-2.0	-2.1	2.3	0.5	0.5
Progressive ratio test 2 active lever presses	0.5	0.7	1.0	1.0	-1.0	-0.8	-0.8	0.7	0.5	-0.7
Progressive ratio test 2 breakpoint	0.6	0.8	1.2	1.1	-1.1	-0.9	-0.9	0.7	0.4	-0.8
Progressive ratio test 2 inactive lever presses	1.2	3.7	5.4	2.3	-2.3	-2.2	-2.2	2.3	-0.1	0.1
Incentive Sensitization - Responses	0.7	1.9	2.9	1.7	-1.7	-1.4	-1.4	0.8	-0.9	-1.4
Incentive Sensitization - Breakpoint	0.6	1.4	2.0	1.4	-1.4	-1.2	-1.1	0.6	-0.9	-1.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.5	-0.1	0.2	0.1	0.3	-0.3	-1.2	0.5
Progressive ratio	0.1	0.2	1.2	-0.2	-0.0	-0.0	0.0	-0.0	-1.1	0.4
Food seeking constrained by brief footshock	1.8	2.3	14.1	-0.5	0.4	-0.2	0.1	1.2	0.1	3.8
Seeking ratio, punishment vs. effort	0.3	0.6	1.2	0.6	-0.6	-0.8	-0.7	1.1	0.4	1.1
Retroperitoneal fat weight	3.2	14.1	20.3	-4.1	4.0	4.3	4.3	-4.5	2.4	-1.6
Reaction time number correct	0.0	0.2	0.3	-0.4	0.4	0.4	0.6	-0.4	0.1	0.4
Reaction time mean minus median	0.0	0.0	0.0	0.2	-0.0	-0.0	0.1	-0.0	0.0	0.0
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	0.0	0.1	0.2	-0.2	0.1	-0.2
Reaction time num false alarms	0.0	0.0	0.2	0.1	0.1	-0.0	0.1	0.1	0.4	0.3
Reaction time num false alarms AUC	0.2	0.4	1.2	-0.4	0.7	0.4	0.5	-0.1	0.9	1.1
Reaction time trials correct on left	0.0	0.2	0.3	-0.4	0.4	0.4	0.6	-0.4	0.1	0.4
Reaction time trials on left	0.0	0.2	0.3	-0.4	0.4	0.4	0.6	-0.4	0.1	0.5
Reaction time mean	0.4	0.8	1.2	1.1	-1.0	-0.9	-1.1	0.8	-0.5	-0.7
Reaction time mean AUC	0.1	0.3	0.7	0.7	-0.6	-0.5	-0.7	0.4	-0.3	-0.8
Median of all reaction times	0.5	0.8	1.3	1.0	-1.0	-0.9	-1.1	0.8	-0.5	-0.8
Reaction time omissions	0.2	0.3	1.3	-0.1	0.3	0.2	0.3	0.1	0.6	1.1
Reaction time false alarm rate	0.2	0.2	0.7	-0.1	0.4	0.2	0.2	0.2	0.7	0.8
Reaction time premature initiation rate	0.0	0.0	0.2	0.2	-0.2	-0.1	-0.3	0.2	0.0	-0.4
Reaction time premature initiations	0.0	0.0	0.1	-0.1	0.1	0.2	0.1	-0.2	0.1	-0.4
Std. dev. reaction times	0.2	0.5	1.0	1.0	-0.8	-0.8	-0.8	0.6	-0.5	-0.5
Reaction time trials completed	0.0	0.2	0.3	-0.4	0.4	0.4	0.6	-0.4	0.1	0.5
Reaction time trials AUC	0.0	0.1	0.3	-0.3	0.3	0.3	0.5	-0.4	0.0	0.2
Run reversals in cocaine runway, females	0.3	0.4	0.6	0.7	-0.6	-0.5	-0.7	0.4	-0.6	-0.8
Run reversals in cocaine runway, males	0.1	0.2	0.9	0.1	-0.1	-0.1	-0.2	0.3	0.9	0.3
Latency to leave start box in cocaine runway	0.3	0.5	0.7	0.8	-0.8	-0.8	-0.8	0.8	-0.2	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.2	-0.3	-0.2	-0.3	0.4	0.3	0.1
Latency to leave start box in cocaine runway, M	1.2	1.1	1.7	1.3	-1.2	-1.3	-1.2	1.1	-0.5	-0.4
Std. dev. time between licks in bursts	0.4	0.7	4.2	-0.5	0.5	0.3	0.2	0.2	0.0	2.1
Total sessions with >9 infusions	0.9	1.2	2.0	1.2	-1.0	-1.1	-1.0	1.4	0.8	0.9
Short access day 1 total inactive lever presses	0.4	0.9	1.4	1.2	-1.1	-1.0	-1.0	0.8	0.3	-0.8
Short access day 10 total inactive lever presses	0.0	0.2	0.3	0.5	-0.6	-0.5	-0.5	0.5	0.3	-0.2
Short access day 1 total infusions	0.2	0.3	1.8	0.1	-0.0	-0.1	-0.1	0.4	1.3	0.5
Short access day 10 total infusions	0.2	0.3	1.9	-0.1	0.1	0.1	0.1	0.3	1.4	0.5
Short access total infusions	0.5	0.7	4.1	-0.2	0.2	0.2	0.2	0.2	2.0	0.5
Short access day 1 locomotion	0.4	0.7	1.5	0.9	-0.7	-0.7	-0.7	0.9	1.2	-0.0
Short access day 10 total locomotion	0.3	1.2	2.4	0.9	-0.8	-1.0	-0.8	1.4	0.8	1.6
Short access total locomotion	0.8	1.2	3.3	0.5	-0.3	-0.5	-0.3	1.2	1.7	1.8
One hour access (0.3 mA shock)	3.3	3.9	6.2	2.5	-2.5	-2.4	-2.2	2.1	-0.5	-0.3
Compulsive drug intake	1.5	2.2	3.6	1.7	-1.7	-1.6	-1.4	1.1	-1.9	-0.2
One hour access (shock baseline)	0.2	0.6	1.2	0.7	-0.7	-0.6	-0.7	0.7	1.1	-0.7
Social response proportion	0.8	1.0	1.4	1.0	-1.1	-0.9	-1.1	0.7	-0.7	-1.2
Social responses	2.5	3.2	4.9	2.0	-2.0	-2.0	-2.2	1.9	-1.3	-0.6
Social time	2.4	3.8	5.9	2.0	-2.0	-2.2	-2.2	2.4	-1.3	1.1
Soleus weight	0.0	0.1	0.2	0.5	-0.4	-0.4	-0.2	0.1	-0.3	-0.2
Bone: stiffness	2.0	3.6	5.3	2.3	-2.3	-2.2	-2.2	2.1	-0.6	-0.3
Tibialis anterior weight	0.6	2.1	3.9	-1.3	1.3	1.5	1.9	-2.0	0.7	-1.2
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.7	0.6	-0.6	-0.7	-0.6	0.8	-0.4	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.9	0.8	-0.8	-0.6	-0.6	0.3	0.0	-0.9
Time to tail flick, test, before self-admin	0.8	0.9	2.8	-0.4	0.5	0.2	0.5	0.3	1.7	1.7
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.4	0.5	0.5	0.4	-0.6	-0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	2.2	-0.0	0.0	0.2	0.2	-0.3	1.5	-1.1
Delta time to tail flick, test, before/after SA	0.6	0.7	3.0	0.4	-0.4	-0.2	-0.5	-0.2	-1.7	-1.2
Tibia length	3.2	9.0	12.7	3.6	-3.5	-3.4	-3.4	2.7	-2.6	-1.1
Ambulatory time before self-admin	0.6	1.8	3.1	1.1	-1.1	-1.4	-1.1	1.6	-1.1	1.8
Ambulatory time after self-admin	0.6	0.9	3.5	-0.1	0.2	-0.1	0.1	0.2	-1.9	1.6
Bone: tissue strength	0.6	0.6	2.2	0.3	-0.3	-0.4	-0.2	0.8	1.0	1.5
Total heroin consumption	0.2	0.2	1.2	-0.3	0.1	0.1	0.3	-0.4	-1.1	0.3
Bone: trabecular number	0.1	0.2	0.6	-0.5	0.5	0.5	0.4	-0.2	0.8	0.4
Bone: trabecular spacing	0.0	0.0	0.2	0.0	-0.1	-0.0	0.1	-0.1	-0.1	-0.4
Bone: trabecular thickness	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	0.1	0.1
Bone: trabecular tissue density	0.5	0.9	1.7	-0.9	0.9	1.1	0.9	-1.3	-0.3	-1.1
Water consumed over 24 hours	0.5	1.1	1.8	1.1	-1.1	-1.1	-1.2	1.4	0.1	0.7
Number of responses in last shaping day	0.2	0.3	1.8	0.1	-0.0	0.0	-0.2	0.3	1.3	-0.3