Tnip2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Tnip2	0.07	0.04	1.5e-08	0.06	0.08	0.07	0.07	1.0e-06	1.1e-07	1.6e-07	3.0e-07
2	Adipose	gene expression	Tnip2	0.06	0.04	3.7e-07	0.04	0.06	0.05	0.04	7.4e-05	8.3e-07	5.6e-06	8.5e-06
3	LHb	mRNA stability	Tnip2	0.11	0.08	8.1e-03	0	-0	-0.01	0.05	2.3e-01	4.5e-01	8.6e-01	2.3e-02
4	NAcc	mRNA stability	Tnip2	0.03	0.02	2.0e-05	0.02	0.02	0.02	0.02	1.2e-03	2.2e-04	5.1e-04	4.7e-04
5	NAcc	gene expression	Tnip2	0.08	0.05	0.0e+00	0.1	0.12	0.12	0.12	2.9e-15	3.0e-17	5.8e-17	2.6e-17
6	Adipose	mRNA stability	Tnip2	0.03	0.03	9.3e-03	0.01	0.01	0.01	0	6.1e-02	9.3e-03	2.7e-02	9.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.2	2.0	3.9	1.3	-1.3	1.1	1.4	2.0	1.3
Area under the delay curve	0.4	0.4	1.0	-0.6	0.2	-0.7	-0.8	-0.4	-1.0
BMI with tail	2.5	8.6	11.9	-2.9	2.8	-1.8	-3.3	-3.0	-3.5
BMI without tail	1.8	5.4	7.2	-2.3	2.4	-1.3	-2.6	-2.4	-2.7
Body weight	6.6	28.7	31.4	-5.6	5.3	-4.9	-5.5	-5.3	-5.4
Weight adjusted by age	2.7	4.1	4.9	-2.1	1.9	-1.9	-2.2	-1.7	-2.2
Bone surface	0.2	0.3	0.8	-0.4	0.2	-0.9	-0.2	0.9	-0.2
Bone volume	0.2	0.4	2.0	0.2	-0.3	-0.1	0.3	1.4	0.3
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	-0.2	0.5	0.2	-0.2	0.1
Number of licking bursts	1.2	1.9	3.3	-1.5	1.5	-1.8	-1.1	-1.3	-0.9
Context. condit. distance diff. score	0.2	0.2	0.4	0.6	-0.6	0.3	0.5	-0.3	0.4
Locomotion velocity, session 1	1.2	1.3	1.6	1.3	-1.1	1.1	1.3	0.6	1.3
Locomotion distance, session 1	0.5	0.7	1.0	0.8	-0.8	0.8	0.8	1.0	0.7
Locomotion velocity, session 2	5.5	6.4	9.1	2.8	-2.5	2.1	2.9	1.6	3.0
Locomotion distance, session 2	3.0	4.2	5.6	2.2	-2.4	1.9	2.1	1.8	1.9
Locomotion velocity, session 3	0.1	0.2	0.4	0.4	-0.7	0.0	0.4	0.2	0.3
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.1	-0.3	-0.2
Stereotopy head waving bouts, day 3	0.8	1.0	2.7	1.1	-0.7	1.6	0.8	0.2	0.8
Stereotopy head waving duration, day 3	0.7	0.8	2.6	1.0	-0.7	1.6	0.7	0.1	0.6
Locomotion velocity, session 7	1.3	1.4	3.7	-1.0	0.9	-1.9	-0.6	-1.5	-0.4
Locomotion distance, session 7	0.2	0.2	0.4	0.3	-0.6	-0.5	0.5	-0.3	0.4
Stereotopy head waving bouts, day 7	1.4	1.6	2.5	-1.1	1.1	-0.5	-1.5	-1.5	-1.6
Stereotopy head waving duration, day 7	2.5	3.0	4.0	-1.7	1.6	-1.2	-1.9	-1.9	-2.0
Locomotion velocity, session 8	1.6	1.9	3.0	1.5	-1.4	0.9	1.7	0.8	1.7
Locomotion distance, session 8	1.9	2.8	3.8	1.9	-1.9	1.4	1.9	0.9	1.8
Degree of sensitization distance	1.0	1.0	2.0	1.0	-0.9	0.4	1.3	0.7	1.4
Degree of sensitization stereotypy	2.2	2.4	3.4	-1.5	1.5	-1.2	-1.8	-1.5	-1.8
Conditioned locomotion	0.2	0.2	0.4	-0.4	-0.0	-0.5	-0.5	-0.1	-0.7
Cocaine response after cond. corrected	1.4	1.6	2.9	1.4	-1.4	1.7	1.1	0.8	0.9
Cocaine response after cond. not corrected	0.5	0.6	1.2	0.9	-0.9	1.1	0.7	0.4	0.6
Cocaine response before conditioning	0.8	0.9	1.7	-1.1	1.1	-1.3	-0.8	-0.7	-0.6
Saline control response	0.2	0.3	0.4	0.5	-0.5	0.4	0.6	0.6	0.6
Bone: connectivity density	0.7	1.1	2.1	1.0	-1.1	0.6	1.0	1.4	1.0
Bone: cortical apparent density	0.3	0.4	1.1	-0.5	0.5	0.2	-0.9	0.3	-1.0
Bone: cortical area	5.9	9.1	12.8	-3.2	3.0	-3.6	-2.9	-2.6	-2.7
Bone: cortical porosity	0.3	0.4	0.5	0.7	-0.7	0.5	0.7	-0.5	0.6
Bone: cortical porosity	0.2	0.2	1.0	0.2	-0.2	0.0	0.1	-1.0	0.0
Bone: cortical thickness	4.3	7.1	8.8	-2.6	2.5	-3.0	-2.7	-2.5	-2.6
Bone: cortical thickness	0.2	0.2	0.6	-0.3	-0.0	-0.1	-0.6	-0.4	-0.8
Bone: cortical tissue density	0.3	0.4	1.0	-0.4	0.5	0.4	-0.8	0.4	-1.0
Condit. Reinf. active minus inactive responses	1.2	1.4	2.5	1.3	-1.2	1.6	1.0	0.9	0.8
Condit. Reinf. active-inactive response ratio	3.0	3.2	4.9	1.9	-1.9	2.2	1.7	1.4	1.6
Condit. Reinf. active responses	0.4	0.5	1.1	0.8	-0.8	1.1	0.6	0.6	0.5
Condit. Reinf. inactive responses	1.2	1.4	2.1	-1.3	1.3	-1.4	-1.2	-0.8	-1.0
Incentive salience index mean	0.1	0.1	0.3	0.3	-0.3	0.6	0.2	0.5	0.1
Condit. Reinf. lever presses	0.6	0.9	1.2	-1.1	1.0	-0.9	-1.0	-0.2	-1.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	-0.7	0.8	-1.0	-0.4	-0.7	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	-0.3	0.2	0.1	0.3	-0.0
Condit. Reinf. active responses	0.1	0.1	0.3	0.1	-0.1	-0.4	0.4	0.1	0.6
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.4	-0.2	0.0	0.6	0.3	0.7
Condit. Reinf. lever presses	0.4	0.5	0.6	-0.7	0.7	-0.8	-0.7	-0.8	-0.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	-0.1	0.1	-0.6	0.1	-0.2	0.2
Conditioned reinforcement - actives	0.4	0.7	1.1	-0.9	0.6	-0.8	-0.9	-0.4	-1.0
Conditioned reinforcement - inactives	0.5	0.8	1.0	-1.0	1.0	-1.0	-0.9	-0.5	-0.9
Conditioned locomotion	1.2	1.6	1.8	-1.3	1.1	-1.2	-1.3	-1.3	-1.3
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.1	0.1	0.2	-0.0	-0.2	0.0
Patch foraging indifference point AUC	0.3	0.5	0.7	0.6	-0.5	0.8	0.7	0.8	0.8
Delay disc. indifference point, 0s delay	1.0	1.1	2.7	-0.8	0.0	-0.9	-1.2	-1.1	-1.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.3	-0.4	0.3	0.2	0.5	0.0
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	-0.0	-0.4	-0.2	-0.3	-0.6	-0.6
Delay disc. indifference point, 24s delay	0.3	0.3	1.0	-0.4	-0.0	-0.4	-0.7	-0.0	-1.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.4	-0.6	0.2	0.2	0.5	0.1
Delay disc. indifference point, 8s delay	0.8	0.9	1.2	-1.0	0.9	-1.1	-1.0	-0.4	-1.0
Indifference point function ln k	0.2	0.3	0.5	0.6	-0.5	0.4	0.7	0.3	0.7
Indifference point function log k	0.2	0.3	0.5	0.6	-0.5	0.4	0.7	0.3	0.7
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.0	0.2	0.2	-0.1	-0.3	-0.0
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	-0.7	0.7	-0.5	-0.7	-0.5	-0.7
Patch foraging total patch changes 18 sec	0.0	0.0	0.2	0.0	0.1	0.4	-0.0	0.0	0.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	-0.1	0.1	0.1	-0.4	-0.5	-0.6
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	-0.1	0.5	0.2	-0.1	-0.2	0.1
Patch foraging time to switch 0 sec	1.1	2.3	3.6	-1.5	1.1	-1.3	-1.7	-1.5	-1.9
Patch foraging water rate 0 sec	0.2	0.3	0.9	-0.6	1.0	-0.8	-0.1	-0.2	0.3
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.4	-0.0	0.6	0.4	0.0	0.5
Patch foraging water rate 18 sec	0.1	0.1	0.3	-0.1	0.5	0.1	-0.1	-0.6	0.0
Patch foraging water rate 24 sec	0.3	0.4	1.4	-0.6	1.2	-0.2	-0.4	-0.6	-0.0
Patch foraging water rate 6 sec	0.8	1.1	2.3	-1.1	1.5	-0.9	-0.9	-1.1	-0.5
Seeking ratio, delayed vs. immediate footshock	3.0	3.7	5.2	1.8	-1.5	1.8	2.0	2.3	2.1
Distance traveled before self-admin	1.0	1.3	1.9	1.3	-1.4	1.2	1.2	0.3	1.1
Distance traveled after self-admin	0.1	0.1	0.3	0.2	-0.5	0.2	-0.0	0.2	-0.3
Extensor digitorum longus weight	2.6	10.4	12.8	-3.3	3.6	-2.6	-3.3	-3.5	-3.0
Bone: elastic displacement	0.8	0.9	1.2	-1.1	1.1	-1.0	-0.9	-0.8	-0.8
Bone: elastic work	3.6	4.7	5.9	-2.3	2.4	-2.1	-2.1	-2.2	-1.8
Bone: endosteal estimation	0.9	2.0	4.2	-1.5	1.4	-2.1	-1.0	-1.3	-0.7
Bone: endosteal perimeter	0.8	1.8	3.7	-1.5	1.5	-1.9	-1.1	-0.8	-0.8
Epididymis fat weight	2.1	7.3	8.3	-2.9	2.6	-2.6	-2.8	-2.5	-2.8
Delta time in closed arm before/after self-admin	0.7	0.7	1.0	0.9	-1.0	0.9	0.8	0.6	0.6
Delta time in open arm before/after self-admin	1.8	1.8	1.9	-1.4	1.2	-1.3	-1.4	-1.4	-1.3
Diff in mean of infusions in LGA sessions	1.1	1.3	2.1	1.2	-1.4	1.2	1.0	1.3	0.7
Delay discount exponential model param	0.3	0.3	0.8	0.5	-0.1	0.6	0.7	0.3	0.9
Extinction: sum of active levers before priming	0.8	0.9	1.3	-1.1	0.9	-1.0	-1.1	-0.3	-1.2
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.1	-0.1	-0.0	-0.4	-0.4	-0.6
Bone: final force	5.4	8.7	14.0	-3.0	2.8	-3.7	-2.6	-2.9	-2.4
Bone: final moment	4.6	7.3	11.6	-2.6	2.6	-3.4	-2.4	-2.9	-2.1
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.2	0.1	-0.0	0.4	-0.1	0.7
Glucose	0.2	0.3	0.8	-0.0	0.2	-0.9	0.4	-0.3	0.7
Heart weight	1.2	1.8	2.6	-1.4	1.4	-1.6	-1.2	-1.3	-1.0
Delay discount hyperbolic model param	0.2	0.3	0.7	0.4	-0.0	0.6	0.6	0.2	0.8
Intermittent access intake day 1-15 change	2.5	5.1	6.1	2.5	-2.4	2.3	2.3	1.8	2.2
Intermittent access intake escalation	1.6	3.4	4.1	2.0	-2.0	1.9	1.9	1.4	1.8
Intermittent access intake escalation 2	2.8	3.2	3.7	1.9	-1.7	1.8	1.9	1.4	1.9
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.6	0.8	-0.7	0.8	0.8	1.3	0.8
Intermitt. access day 15 inactive lever presses	0.4	0.8	0.9	1.0	-0.8	0.9	1.0	0.8	1.0
Intermitt. access escalation Index	0.7	0.9	1.2	1.1	-1.0	1.0	1.1	0.4	1.0
Intermittent access day 1 total infusions	0.8	1.3	2.2	-1.2	0.9	-1.1	-1.3	-0.5	-1.5
Intermittent access day 15 total infusions	0.0	0.0	0.2	0.1	-0.2	0.0	-0.0	0.4	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.3	-0.3	0.3	0.3	0.6	0.2
Intermittent access total infusions	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.4	0.3	-0.4
Intermittent access day 1 locomotion	0.7	0.8	1.2	-1.0	0.8	-0.9	-1.0	-0.6	-1.1
Intermittent access day 15 total locomotion	0.2	0.4	0.9	-0.6	0.3	-0.6	-0.8	-0.4	-1.0
Intermittent access total locomotion	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.2	0.1	-0.3
Intermittent access standard deviation	0.3	0.7	0.8	0.9	-0.8	0.8	0.9	0.5	0.8
Left kidney weight	4.7	22.0	24.3	-4.8	4.9	-4.3	-4.7	-4.9	-4.5
Right kidney weight	3.9	17.6	19.4	-4.3	4.1	-3.7	-4.3	-4.4	-4.3
Cocaine induced anxiety	0.5	0.7	1.0	0.9	-0.8	0.9	1.0	0.3	1.0
Post-drug Anxiety	0.1	0.1	0.4	0.4	-0.6	0.4	0.3	0.1	0.1
Baseline Anxiety	2.1	2.4	4.2	-1.6	1.1	-1.4	-1.8	-1.0	-2.1
Tail length	0.8	3.2	4.5	-1.9	2.1	-1.9	-1.6	-1.7	-1.3
Length with tail	3.6	15.7	19.1	-4.3	4.4	-4.1	-3.7	-3.9	-3.3
Length without tail	3.2	10.3	12.0	-3.5	3.4	-3.3	-3.1	-3.1	-2.8
Times rat made contact with spout	1.2	1.4	2.2	1.2	-1.0	1.0	1.4	1.1	1.5
Lifetime Intake	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4	0.4	-0.4
Liver weight, left	0.5	0.9	1.1	-1.0	0.9	-1.1	-0.9	-0.9	-0.9
Liver weight, right	3.0	5.3	6.5	-2.5	2.5	-1.6	-2.5	-2.1	-2.4
Locomotor activity	0.1	0.2	0.4	-0.2	0.5	-0.6	0.3	-0.0	0.6
Locomotor testing distance	0.6	1.0	1.4	-1.1	1.2	-1.0	-0.9	-1.1	-0.7
Locomotor testing rearing	1.1	2.1	3.0	-1.5	1.7	-1.5	-1.2	-1.6	-1.0
Locomotion in novel chamber	0.4	0.5	0.8	0.9	-0.9	0.7	0.7	-0.4	0.6
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	0.3	-0.5	0.1	0.2	0.1	0.0
Fecal boli incidents, locomotor time 1	0.3	0.5	0.7	0.8	-0.6	0.8	0.8	0.2	0.9
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	0.7	-0.6	0.4	0.8	0.4	0.9
Time >=10cm from walls, locomotor time 1	2.3	2.4	3.5	-1.5	1.1	-1.4	-1.7	-1.7	-1.9
Bouts of movement, locomotor time 1	0.2	0.2	0.5	-0.4	0.3	-0.3	-0.6	-0.3	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.4	0.3	-0.3	-0.6	-0.7	-0.7
Rest time, locomotor task time 1	1.8	2.2	3.2	-1.5	1.7	-1.5	-1.3	-1.8	-1.0
Distance moved, locomotor task time 1	0.1	0.2	0.5	0.4	-0.4	0.3	0.3	0.7	0.2
Vertical activity count, locomotor time 1	0.7	1.7	2.5	1.3	-1.3	1.2	1.2	1.6	1.1
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.0	-1.0	0.8	-0.9	-1.0	-0.8	-1.0
Bouts of movement, locomotor time 2	0.0	0.1	0.2	0.1	-0.2	0.3	-0.1	0.4	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.2	0.1	-0.0	-0.4	0.2	-0.5
Rest time, locomotor task time 2	1.0	1.2	1.8	-1.3	1.3	-1.2	-1.1	-0.8	-0.9
Distance moved, locomotor task time 2	0.5	0.6	0.8	0.9	-0.9	0.8	0.7	0.6	0.6
Vertical activity count, locomotor time 2	1.4	1.9	2.8	1.5	-1.7	1.4	1.4	1.0	1.3
Light reinforcement 1	2.0	4.9	5.4	-2.3	2.3	-1.9	-2.3	-2.2	-2.2
Light reinforcement 2	2.7	4.2	5.0	-2.1	2.2	-1.9	-2.0	-2.1	-1.8
Bone: marrow area	0.8	1.7	3.8	-1.4	1.3	-2.0	-0.9	-1.3	-0.7
Bone: maximum diameter	3.7	6.9	8.7	-2.8	3.0	-2.8	-2.6	-2.2	-2.4
Bone: maximum force	3.6	6.4	10.0	-2.6	2.6	-3.2	-2.3	-2.2	-2.1
Bone: maximum moment	2.9	5.1	7.8	-2.3	2.4	-2.8	-2.0	-2.2	-1.8
Mean time between licks in bursts	0.9	2.1	3.7	1.5	-1.1	1.2	1.7	1.2	1.9
Mean num. licks in bursts	3.0	4.6	5.8	2.3	-2.2	2.4	2.1	2.1	1.9
Cd content in liver	0.1	0.1	0.2	0.2	-0.2	0.1	0.4	0.2	0.5
Co content in liver	0.5	0.6	1.7	-0.6	0.3	-1.3	-0.4	-1.1	-0.3
Cu content in liver	0.9	1.1	1.7	1.2	-1.3	0.6	1.2	0.7	1.1
Fe content in liver	3.2	3.9	6.4	2.4	-2.5	1.6	2.1	0.7	1.9
K content in liver	0.1	0.1	0.1	-0.1	-0.3	-0.4	-0.1	0.4	-0.3
Mg content in liver	1.3	1.3	1.5	-1.2	1.0	-1.2	-1.2	-1.1	-1.2
Mn content in liver	0.5	0.6	1.1	0.6	-0.6	0.3	0.8	1.1	0.9
Na content in liver	0.2	0.2	0.7	0.5	-0.9	-0.3	0.4	0.1	0.2
Rb content in liver	0.3	0.4	1.1	-0.4	0.3	-1.0	-0.3	-0.8	-0.3
Se content in liver	0.1	0.2	0.6	0.4	-0.2	0.8	0.1	0.4	0.0
Sr content in liver	1.9	1.6	2.5	-1.4	1.6	-1.0	-1.3	-1.2	-1.1
Zn content in liver	0.1	0.1	0.3	-0.1	0.5	0.5	-0.2	-0.2	-0.2
Bone: minimum diameter	1.2	2.2	5.4	-1.6	1.5	-2.3	-1.1	-1.1	-0.9
Time in familiar zone, hab. session 1	0.7	0.7	1.0	1.0	-0.9	0.9	0.8	0.2	0.8
Time in novel zone, hab. session 1	0.4	0.4	0.7	-0.7	0.9	-0.3	-0.7	-0.1	-0.6
Total zone transitions, hab. session 1	0.2	0.2	0.4	0.4	-0.5	0.3	0.5	0.6	0.5
Total locomotion distance, hab. session 1	0.8	1.2	2.2	1.0	-1.0	0.7	1.1	1.5	1.1
Locomotion velocity, hab. session 1	0.4	0.6	1.5	0.5	-0.7	0.1	0.8	1.2	0.8
Time in familiar zone, hab. session 2	3.5	3.6	4.5	2.1	-2.1	2.1	1.8	1.7	1.5
Time in novel zone, hab. session 2	6.1	6.1	8.5	-2.7	2.9	-2.2	-2.5	-2.3	-2.1
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1	-0.1	-0.0
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.1	0.1	0.3	0.2	0.2	0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.1	0.1	0.2	0.2	0.2	0.2
Novel to familiar place preference ratio	0.2	0.2	0.7	0.3	-0.4	0.2	0.3	0.8	0.2
Novelty place preference	0.1	0.1	0.5	0.1	-0.2	-0.0	0.2	0.7	0.1
Time in novel zone, NPP test	0.1	0.1	0.4	0.0	-0.1	-0.0	0.1	0.7	0.1
Total zone transitions, NPP test	0.1	0.1	0.2	0.2	-0.3	0.3	0.2	0.5	0.1
Total locomotion distance, NPP test	0.4	0.6	1.0	0.8	-0.9	0.8	0.6	1.0	0.5
Locomotion velocity, NPP test	0.7	0.9	1.4	1.0	-1.2	0.9	0.8	1.1	0.6
Intraocular pressure	0.2	0.3	0.5	-0.6	0.7	-0.3	-0.6	-0.5	-0.6
Delta distance traveled before/after self-admin	0.7	0.8	1.6	-0.9	0.6	-0.8	-1.1	-0.1	-1.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	0.2	-0.4	0.2	0.0	0.7	-0.1
Parametrial fat weight	0.2	0.4	0.7	0.8	-0.8	0.8	0.5	0.2	0.4
Pavlov. Cond. lever latency	0.8	1.0	1.5	1.2	-1.0	1.2	1.1	-0.0	1.0
Pavlov. Cond. magazine entry latency	1.0	1.3	2.6	1.0	-0.8	1.3	0.9	1.6	0.9
Pavlov. Cond. change in total contacts	0.2	0.2	1.2	0.0	-0.1	0.2	0.0	1.1	0.0
Pavlov. Cond. index score	0.3	0.3	1.9	0.2	-0.3	0.2	0.2	1.4	0.2
Pavlov. Cond. latency score	0.2	0.2	1.5	-0.1	-0.0	-0.1	-0.0	1.2	-0.0
Pavlov. Cond. lever contacts	0.5	0.6	1.1	-0.9	0.7	-1.1	-0.8	0.1	-0.7
Pavlov. Cond. magazine entry number	1.4	1.8	3.1	-1.3	1.2	-1.4	-1.2	-1.8	-1.2
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.0	-0.6	0.6	-0.2	-0.8	-1.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.5	0.1	-0.1	0.1	0.1	1.2	0.1
Pavlov. Cond. response bias	0.3	0.3	1.2	0.4	-0.4	0.5	0.4	1.1	0.4
Pavlov. Cond. lever latency	0.6	0.8	1.2	-0.8	0.8	-0.6	-0.9	-1.1	-1.0
Pavlov. Cond. magazine entry latency	1.4	1.7	2.1	-1.4	1.3	-1.2	-1.3	-1.4	-1.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.2	-0.1
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1	0.2	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0	0.2	0.0
Pavlov. Cond. lever contacts	1.0	1.4	2.1	1.1	-1.1	1.0	1.2	1.4	1.2
Pavlov. Cond. magazine entry number	1.8	2.2	2.8	1.6	-1.7	1.4	1.5	1.4	1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.2	1.5	1.1	-1.1	0.7	1.2	1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	0.3	-0.0	-0.1	0.1	-0.1
Pavlov. Cond. response bias	0.0	0.1	0.1	0.2	-0.2	0.1	0.2	0.3	0.3
Time in closed arm before self-admin	0.1	0.1	0.2	-0.3	0.5	-0.3	-0.2	0.2	-0.1
Time in closed arm after self-admin	0.3	0.3	0.6	0.6	-0.6	0.7	0.6	0.4	0.5
Time in open arm before self-admin	0.2	0.2	0.4	-0.4	0.5	-0.5	-0.3	-0.7	-0.2
Time in open arm after self-admin	1.7	1.9	2.2	-1.4	1.4	-1.5	-1.3	-1.3	-1.3
Bone: periosteal estimation	3.3	7.1	12.1	-2.8	2.7	-3.5	-2.4	-2.2	-2.1
Bone: periosteal perimeter	3.8	6.5	10.2	-2.8	2.6	-3.2	-2.4	-2.0	-2.2
Bone: post-yield work	0.5	0.8	1.1	0.9	-0.7	1.0	0.9	1.0	0.9
Progressive ratio test 1 active lever presses	0.8	1.0	1.4	-1.1	1.0	-1.0	-1.1	-0.0	-1.2
Progressive ratio test 1 breakpoint	0.8	1.0	1.4	-1.1	0.9	-1.0	-1.1	0.0	-1.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	-0.1	-0.5
Progressive ratio test 2 active lever presses	0.1	0.2	0.7	-0.2	0.0	-0.2	-0.3	0.8	-0.4
Progressive ratio test 2 breakpoint	0.1	0.2	0.5	-0.2	0.0	-0.2	-0.3	0.7	-0.5
Progressive ratio test 2 inactive lever presses	0.3	0.5	0.8	-0.8	0.6	-0.8	-0.9	-0.1	-0.9
Incentive Sensitization - Responses	0.1	0.2	0.6	0.3	-0.4	0.3	0.1	0.8	0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.2	-0.3	0.2	0.1	0.7	0.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.0	-0.2	0.2	-0.2	0.4	-0.4
Progressive ratio	0.1	0.2	0.4	-0.5	0.4	-0.6	-0.4	-0.3	-0.4
Food seeking constrained by brief footshock	1.2	1.5	2.4	-1.5	1.3	-1.2	-1.3	-0.2	-1.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.5	-0.1	0.1	0.2	0.0	0.7	0.1
Retroperitoneal fat weight	0.5	2.0	3.0	-1.4	1.1	-1.4	-1.6	-1.3	-1.7
Reaction time number correct	0.4	0.9	2.4	-0.9	1.6	-0.5	-0.6	-1.1	-0.2
Reaction time mean minus median	0.7	1.7	2.1	1.4	-1.3	1.4	1.3	1.1	1.3
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.3	0.2	0.0	-0.4	-0.5	-0.5
Reaction time num false alarms	1.3	1.8	3.2	-1.3	0.8	-1.2	-1.5	-1.2	-1.8
Reaction time num false alarms AUC	1.9	2.9	4.8	-1.6	1.2	-1.4	-2.0	-1.6	-2.2
Reaction time trials correct on left	0.4	0.9	2.4	-0.9	1.6	-0.5	-0.6	-1.1	-0.2
Reaction time trials on left	0.4	0.7	2.2	-0.8	1.5	-0.4	-0.5	-1.0	-0.1
Reaction time mean	1.0	1.5	2.4	1.3	-1.5	1.2	1.2	1.2	1.0
Reaction time mean AUC	0.9	1.4	2.2	1.3	-1.5	1.2	1.1	1.1	0.9
Median of all reaction times	0.8	1.2	2.0	1.2	-1.4	0.9	1.0	1.1	0.8
Reaction time omissions	0.5	0.7	1.7	0.9	-0.8	1.3	0.6	0.7	0.5
Reaction time false alarm rate	1.1	1.5	3.6	-1.1	0.4	-1.0	-1.5	-0.9	-1.9
Reaction time premature initiation rate	0.1	0.1	0.2	-0.2	0.1	0.1	-0.4	-0.4	-0.5
Reaction time premature initiations	0.2	0.4	0.9	-0.6	0.9	-0.1	-0.6	-0.9	-0.5
Std. dev. reaction times	0.5	0.9	1.5	1.1	-1.1	1.2	0.8	0.8	0.7
Reaction time trials completed	0.4	0.7	2.2	-0.8	1.5	-0.4	-0.5	-1.0	-0.1
Reaction time trials AUC	0.3	0.6	2.0	-0.8	1.4	-0.4	-0.5	-0.9	-0.0
Run reversals in cocaine runway, females	1.0	1.0	2.2	1.0	-1.5	1.0	0.7	1.0	0.3
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.6	0.5	-0.2	-0.6	0.1	-0.6
Latency to leave start box in cocaine runway	1.8	2.1	5.1	-1.2	1.0	-1.4	-1.2	-2.2	-1.3
Latency to leave start box in cocaine runway, F	3.2	3.7	5.6	-1.9	1.7	-1.8	-1.9	-2.4	-1.9
Latency to leave start box in cocaine runway, M	0.2	0.2	1.2	0.1	-0.1	-0.2	0.1	-1.1	0.0
Std. dev. time between licks in bursts	0.3	0.4	0.8	0.5	-0.4	0.0	0.8	0.6	0.9
Total sessions with >9 infusions	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.4	0.2	-0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.2	0.3	-0.2	-0.1	-0.6	-0.1
Short access day 10 total inactive lever presses	0.5	1.3	2.5	1.2	-0.7	1.1	1.4	0.6	1.6
Short access day 1 total infusions	0.0	0.1	0.2	-0.2	0.0	-0.2	-0.3	0.2	-0.4
Short access day 10 total infusions	0.1	0.2	0.9	-0.1	0.1	-0.1	-0.0	1.0	-0.0
Short access total infusions	0.1	0.1	0.7	0.0	-0.0	-0.0	0.0	0.8	0.0
Short access day 1 locomotion	0.4	0.4	0.6	-0.8	0.7	-0.7	-0.8	-0.0	-0.8
Short access day 10 total locomotion	1.3	2.5	2.9	1.7	-1.5	1.6	1.7	1.2	1.7
Short access total locomotion	0.5	0.6	0.7	0.8	-0.7	0.8	0.8	0.8	0.8
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.1	-0.2	0.0
Compulsive drug intake	0.1	0.1	0.2	0.4	-0.4	0.4	0.4	-0.4	0.3
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.1	0.1	-0.1
Social response proportion	1.5	1.7	2.3	1.3	-1.0	1.4	1.4	1.2	1.5
Social responses	0.1	0.1	0.2	0.0	0.4	0.2	0.2	-0.2	0.4
Social time	1.3	1.8	2.0	1.4	-1.4	1.2	1.4	1.3	1.4
Soleus weight	2.5	7.3	11.2	-2.8	3.3	-2.0	-2.6	-3.1	-2.2
Bone: stiffness	1.0	1.7	4.1	-1.3	0.9	-2.0	-1.1	-1.0	-1.1
Tibialis anterior weight	1.4	4.9	6.0	-2.3	2.5	-1.7	-2.3	-2.3	-2.1
Time to tail flick, vehicle, before self-admin	0.4	0.5	0.8	0.8	-0.9	0.9	0.5	0.2	0.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.7	0.7	-0.7	0.8	0.6	0.5	0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	0.4	-0.2	-0.2	-0.3	-0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.8	-0.6	0.9	-0.7	-0.3	0.0	-0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	0.4	-0.4	-0.2	0.1	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	0.0	0.2	-0.1	0.2	0.7	0.4
Tibia length	1.4	4.0	9.6	-1.9	1.6	-3.1	-1.7	-1.6	-1.6
Ambulatory time before self-admin	0.5	0.8	1.5	1.0	-1.2	1.0	0.9	-0.1	0.7
Ambulatory time after self-admin	0.8	0.9	2.0	1.1	-1.4	1.0	0.8	0.7	0.5
Bone: tissue strength	1.4	1.4	2.6	-1.2	1.6	-1.3	-0.8	-1.3	-0.5
Total heroin consumption	0.5	0.6	0.9	-0.8	0.9	-0.5	-0.7	-1.0	-0.6
Bone: trabecular number	0.5	0.8	1.4	0.9	-0.8	1.0	0.7	1.2	0.6
Bone: trabecular spacing	1.5	2.0	3.4	-1.5	1.5	-1.9	-1.2	-1.2	-1.0
Bone: trabecular thickness	1.5	1.8	3.4	1.2	-1.2	1.5	1.1	1.8	1.0
Bone: trabecular tissue density	0.2	0.4	0.6	0.5	-0.7	0.1	0.6	0.8	0.5
Water consumed over 24 hours	1.3	1.8	3.5	1.3	-0.9	1.0	1.6	1.1	1.9
Number of responses in last shaping day	0.1	0.1	0.4	0.0	-0.5	0.0	-0.3	0.4	-0.6