Tnik

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Tnik	0.13	0.07	4.4e-04	0	0.04	0.04	0.04	1.4e-01	6.1e-05	1.4e-04	2.6e-04
2	Adipose	mRNA stability	Tnik	0.09	0.05	6.4e-08	0.05	0.05	0.03	0.04	5.6e-06	2.2e-06	2.0e-04	1.5e-05
3	Adipose	gene expression	Tnik	0.18	0.08	0.0e+00	0.16	0.16	0.16	0.16	4.3e-17	1.1e-17	1.3e-17	1.5e-17
4	Adipose	alternative TSS	XM_063281549.1	0.05	0.03	9.9e-07	0.03	0.04	0.04	0.04	1.5e-04	2.4e-05	5.3e-05	7.6e-05
5	IC	alternative polyA	XM_063281546.1	0.08	0.05	8.8e-03	0.04	0.02	0.04	0.01	1.1e-02	4.9e-02	1.3e-02	7.2e-02
6	Adipose	alternative TSS	NM_001106422.1	0.03	0.02	4.7e-03	0.02	0.01	0.02	0.01	4.9e-03	9.0e-03	6.1e-03	9.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.4	2.8	0.0	1.7	-0.9	0.4	-1.5	1.5
Area under the delay curve	2.4	3.7	4.6	2.1	1.3	-2.1	1.5	-2.1	2.1
BMI with tail	0.1	0.3	0.8	0.1	0.9	0.4	-0.7	0.1	-0.4
BMI without tail	0.2	0.9	1.6	0.6	1.1	-0.9	0.5	-1.3	1.1
Body weight	0.2	0.7	2.9	1.7	1.0	0.1	-0.6	-0.2	-0.0
Weight adjusted by age	0.3	0.9	4.5	-0.0	-2.1	0.6	0.3	0.3	-0.3
Bone surface	0.0	0.1	0.2	-0.1	0.2	0.4	-0.5	-0.1	0.1
Bone volume	0.3	0.6	1.4	0.4	0.0	-0.6	0.6	-1.1	1.2
Breakpoint value in progressive ratio session	0.9	1.6	2.3	1.5	1.4	-1.2	0.5	-1.3	1.4
Number of licking bursts	0.1	0.2	0.4	0.7	-0.5	-0.3	0.4	-0.2	0.2
Context. condit. distance diff. score	1.7	2.1	4.4	-1.9	2.1	0.7	-1.3	1.0	-1.1
Locomotion velocity, session 1	2.7	3.0	5.1	-1.4	-1.0	2.3	-1.8	1.8	-2.0
Locomotion distance, session 1	2.0	2.5	4.5	-1.5	-0.5	2.1	-1.9	1.5	-1.6
Locomotion velocity, session 2	0.8	1.0	1.7	-0.2	-1.3	1.0	-0.4	1.1	-1.3
Locomotion distance, session 2	0.7	1.0	2.1	-0.8	-0.9	1.4	-1.1	0.8	-0.9
Locomotion velocity, session 3	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.2	-0.1	0.0
Locomotion distance, session 3	0.3	0.3	0.7	-0.4	-0.3	0.8	-0.8	0.3	-0.4
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.3	0.4	-0.4
Stereotopy head waving duration, day 3	0.2	0.2	1.3	0.1	1.1	-0.4	-0.1	-0.0	-0.1
Locomotion velocity, session 7	0.6	0.7	2.2	-0.0	-0.0	0.5	-0.5	1.3	-1.5
Locomotion distance, session 7	0.3	0.4	1.0	0.4	-0.6	-0.8	1.0	0.1	-0.1
Stereotopy head waving bouts, day 7	1.2	1.3	2.4	-0.9	0.9	1.2	-1.6	1.1	-1.1
Stereotopy head waving duration, day 7	1.4	1.8	3.3	-1.3	1.4	1.3	-1.8	0.9	-1.0
Locomotion velocity, session 8	0.5	0.7	1.1	-0.5	0.9	0.7	-0.9	0.8	-1.0
Locomotion distance, session 8	1.0	1.4	2.4	-1.5	0.8	1.2	-1.3	1.1	-1.1
Degree of sensitization distance	0.9	1.0	2.5	1.1	-0.8	-1.3	1.6	-0.2	0.2
Degree of sensitization stereotypy	1.4	1.5	2.7	-1.1	1.6	1.0	-1.7	0.9	-0.8
Conditioned locomotion	2.4	2.8	4.8	1.1	0.3	-1.8	1.7	-2.1	2.2
Cocaine response after cond. corrected	1.5	2.2	3.0	1.7	-0.3	-1.7	1.6	-1.5	1.5
Cocaine response after cond. not corrected	0.8	1.2	2.0	1.4	-0.8	-1.1	1.2	-1.0	0.9
Cocaine response before conditioning	1.5	1.8	2.5	-1.2	0.1	1.6	-1.5	1.4	-1.5
Saline control response	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	-0.0	0.1
Bone: connectivity density	0.5	0.7	3.1	-0.6	1.8	0.3	-0.9	0.1	-0.2
Bone: cortical apparent density	0.3	0.4	0.8	-0.8	-0.1	-0.3	0.5	-0.9	0.8
Bone: cortical area	0.0	0.0	0.1	-0.2	0.2	0.2	-0.0	0.3	-0.1
Bone: cortical porosity	0.3	0.3	0.8	0.9	0.8	-0.5	0.2	0.4	-0.4
Bone: cortical porosity	0.4	0.4	1.2	1.1	0.7	-0.8	0.4	0.0	-0.1
Bone: cortical thickness	0.1	0.1	0.5	-0.3	0.7	-0.3	0.3	-0.2	0.3
Bone: cortical thickness	0.1	0.1	0.3	-0.6	0.2	0.3	-0.3	0.2	-0.1
Bone: cortical tissue density	0.3	0.4	0.9	-0.8	-0.1	-0.3	0.5	-1.0	0.8
Condit. Reinf. active minus inactive responses	1.3	1.5	3.8	2.0	-1.6	-0.7	1.1	-0.6	0.6
Condit. Reinf. active-inactive response ratio	1.8	1.9	5.3	2.3	-1.3	-1.2	1.4	-0.7	0.8
Condit. Reinf. active responses	1.3	1.7	4.7	2.2	-1.3	-1.0	1.3	-0.8	0.8
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	-0.0	-0.2	0.2	-0.3	0.2
Incentive salience index mean	2.5	3.2	6.5	2.6	-1.8	-1.3	1.8	-1.4	1.5
Condit. Reinf. lever presses	1.7	2.6	4.1	2.0	-1.1	-1.3	1.6	-1.7	1.7
Condit. Reinf. active minus inactive responses	0.5	0.8	1.5	1.0	0.1	0.5	-0.8	1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.3	0.5	2.8	1.7	0.2	-0.4	0.2	-0.2	0.2
Condit. Reinf. active responses	2.2	3.2	7.2	0.2	-1.0	1.7	-1.4	2.5	-2.7
Condit. Reinf. inactive responses	3.6	5.4	11.3	-1.2	-1.5	2.3	-1.6	3.1	-3.4
Condit. Reinf. lever presses	0.5	0.7	1.3	0.1	0.5	0.9	-1.2	0.8	-1.0
Condit. Reinf. lever reinforcers received	2.1	2.9	6.5	0.0	-0.8	1.7	-1.4	2.4	-2.6
Conditioned reinforcement - actives	0.3	1.1	2.8	1.7	-1.0	-0.8	1.0	-0.8	0.8
Conditioned reinforcement - inactives	0.0	0.1	0.2	0.4	-0.4	-0.0	-0.0	-0.1	0.1
Conditioned locomotion	0.5	0.8	2.5	1.6	-0.7	-0.5	0.6	-0.7	0.8
Patch foraging indifference point 0 sec	0.2	0.6	1.2	-1.1	1.0	0.6	-0.8	0.6	-0.6
Patch foraging indifference point AUC	4.4	10.4	15.6	-3.8	1.5	3.7	-4.0	2.9	-2.8
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	-0.1	-0.4	0.8	-0.7	0.8	-0.8
Delay disc. indifference point, 16s delay	4.5	6.4	9.2	2.2	1.9	-2.8	1.9	-3.0	3.0
Delay disc. indifference point, 2s delay	2.6	2.9	4.4	2.1	0.8	-1.9	1.5	-1.8	1.8
Delay disc. indifference point, 24s delay	0.7	1.1	3.2	0.6	1.8	-1.0	0.4	-0.9	0.9
Delay disc. indifference point, 4s delay	1.6	1.7	2.4	1.2	0.8	-1.5	1.2	-1.6	1.4
Delay disc. indifference point, 8s delay	0.4	0.7	1.8	1.3	0.4	-1.0	0.7	-0.7	0.6
Indifference point function ln k	2.6	7.8	11.4	3.2	-1.7	-3.0	3.4	-2.7	2.6
Indifference point function log k	2.6	7.8	11.4	3.2	-1.7	-3.0	3.4	-2.7	2.6
Patch foraging total patch changes 0 sec	0.2	0.6	1.6	-1.3	0.9	0.6	-0.7	0.6	-0.5
Patch foraging total patch changes 12 sec	6.5	8.7	13.0	-3.6	1.2	3.3	-3.5	2.7	-2.7
Patch foraging total patch changes 18 sec	1.5	3.6	5.1	-1.8	1.0	2.0	-2.3	2.0	-2.0
Patch foraging total patch changes 24 sec	2.5	8.7	13.9	-3.4	2.2	3.2	-3.7	2.5	-2.3
Patch foraging total patch changes 6 sec	3.5	5.9	11.4	-3.4	1.8	2.4	-2.7	1.9	-2.0
Patch foraging time to switch 0 sec	1.2	4.7	9.5	3.1	-0.6	-2.7	2.6	-1.6	1.5
Patch foraging water rate 0 sec	0.6	2.3	9.1	-3.0	0.4	1.6	-1.3	-0.0	0.2
Patch foraging water rate 12 sec	0.1	0.4	0.8	-0.4	-0.4	-0.2	0.5	-0.8	0.9
Patch foraging water rate 18 sec	0.2	0.5	1.0	-0.7	-0.8	1.0	-0.7	0.3	-0.3
Patch foraging water rate 24 sec	0.9	1.2	3.5	-1.9	1.3	0.9	-1.2	0.0	0.1
Patch foraging water rate 6 sec	0.7	1.0	2.7	-0.0	0.0	-0.7	0.8	-1.5	1.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.8	-0.8	1.3	0.6	-1.2	0.6	-0.6
Distance traveled before self-admin	1.0	2.2	3.2	-1.2	0.9	1.6	-1.8	1.7	-1.5
Distance traveled after self-admin	0.9	1.5	2.3	-1.2	0.6	1.2	-1.3	1.5	-1.4
Extensor digitorum longus weight	0.7	2.9	4.7	2.2	1.7	-1.7	0.8	-1.7	1.8
Bone: elastic displacement	0.2	0.2	0.6	0.2	0.8	-0.2	-0.2	0.7	-0.6
Bone: elastic work	0.2	0.3	0.7	-0.3	-0.2	0.5	-0.3	0.8	-0.7
Bone: endosteal estimation	0.3	0.6	1.8	1.4	-1.2	0.3	0.1	0.6	-0.4
Bone: endosteal perimeter	0.2	0.5	2.2	0.4	-1.5	0.4	0.1	0.3	-0.1
Epididymis fat weight	0.1	0.3	1.7	1.3	0.2	-0.4	0.2	-0.1	0.0
Delta time in closed arm before/after self-admin	1.3	1.2	5.7	0.4	2.4	-0.4	-0.6	-0.4	0.7
Delta time in open arm before/after self-admin	0.7	0.9	1.9	0.1	-1.3	0.5	-0.1	1.4	-1.2
Diff in mean of infusions in LGA sessions	0.2	0.4	1.3	0.6	1.2	-0.6	0.1	-0.2	0.2
Delay discount exponential model param	2.8	3.7	4.8	-2.1	-1.4	2.2	-1.5	2.1	-2.0
Extinction: sum of active levers before priming	0.2	0.3	1.1	1.1	0.2	-0.3	0.1	-0.7	0.5
Active lever presses in extinction session 6	0.8	0.8	2.5	1.6	0.7	-0.9	0.4	-0.7	0.5
Bone: final force	0.1	0.2	0.6	0.7	0.2	0.4	-0.4	0.5	-0.4
Bone: final moment	0.2	0.3	0.4	0.5	0.6	0.5	-0.7	0.6	-0.5
Food consumed during 24 hour testing period	0.0	0.1	0.2	0.5	-0.0	0.2	-0.3	0.2	-0.2
Glucose	0.4	0.7	2.5	-0.2	-1.6	-0.2	0.9	-0.4	0.6
Heart weight	0.7	1.2	2.6	-0.8	1.5	1.1	-1.6	0.3	-0.2
Delay discount hyperbolic model param	2.8	3.7	5.0	-2.2	-1.3	2.2	-1.5	2.1	-2.0
Intermittent access intake day 1-15 change	0.1	0.5	0.9	0.5	0.6	-1.0	0.7	-0.9	0.6
Intermittent access intake escalation	0.0	0.2	0.4	0.1	0.5	-0.6	0.4	-0.6	0.3
Intermittent access intake escalation 2	0.1	0.2	0.6	-0.3	-0.1	0.2	-0.1	0.6	-0.8
Intermitt. access day 1 inactive lever presses	0.1	1.0	1.7	0.8	-0.2	-1.1	1.2	-1.3	1.2
Intermitt. access day 15 inactive lever presses	0.1	0.6	3.2	-0.3	-1.8	0.5	0.3	-0.3	0.3
Intermitt. access escalation Index	0.4	1.2	3.2	-1.8	0.2	1.1	-1.0	0.9	-0.9
Intermittent access day 1 total infusions	0.9	2.6	12.9	1.0	-3.6	0.1	1.1	0.2	-0.1
Intermittent access day 15 total infusions	0.2	0.5	1.8	-0.2	-1.4	0.4	0.0	0.6	-0.8
Intermittent access terminal intake (last 3 days)	0.7	1.2	6.2	0.0	-2.5	0.5	0.4	0.5	-0.6
Intermittent access total infusions	1.0	1.2	4.8	-0.1	-2.2	0.9	-0.1	0.8	-0.9
Intermittent access day 1 locomotion	0.7	1.3	6.5	0.9	-2.5	0.0	0.8	-0.1	0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.8	0.9	-0.3	-0.4	0.4	0.1	-0.2
Intermittent access total locomotion	0.5	0.5	1.7	1.0	-1.3	-0.3	0.7	-0.0	0.0
Intermittent access standard deviation	0.1	0.6	1.0	1.0	-0.5	-0.8	0.8	-0.9	0.7
Left kidney weight	0.0	0.1	0.2	0.2	0.5	0.3	-0.4	-0.0	0.1
Right kidney weight	0.1	0.6	2.7	-0.1	1.6	0.3	-0.8	0.0	-0.0
Cocaine induced anxiety	0.1	0.1	0.4	-0.0	0.2	0.5	-0.7	-0.3	-0.1
Post-drug Anxiety	0.4	0.5	1.3	0.6	-0.5	-0.2	0.3	-1.1	1.0
Baseline Anxiety	0.1	0.2	0.6	-0.2	-0.8	-0.1	0.4	0.4	-0.1
Tail length	0.2	1.0	1.5	1.2	0.4	-1.1	0.8	-1.2	1.1
Length with tail	0.2	0.8	4.3	2.1	0.2	0.2	-0.5	0.3	-0.2
Length without tail	0.6	3.0	5.0	1.0	0.9	1.7	-2.2	2.0	-2.0
Times rat made contact with spout	0.4	0.5	1.0	0.1	-1.0	0.8	-0.4	0.8	-0.8
Lifetime Intake	1.2	1.5	6.7	-0.1	-2.6	1.0	-0.1	0.8	-0.9
Liver weight, left	1.3	2.2	7.4	0.1	-2.7	1.3	-0.2	1.4	-1.5
Liver weight, right	1.0	1.8	2.6	-1.3	-1.6	1.1	-0.3	1.6	-1.6
Locomotor activity	2.2	3.5	6.2	0.0	-0.2	2.1	-2.1	2.5	-2.4
Locomotor testing distance	1.4	3.5	6.4	0.5	0.3	1.9	-2.1	2.5	-2.4
Locomotor testing rearing	1.2	4.3	6.1	-1.4	0.6	2.4	-2.5	2.5	-2.4
Locomotion in novel chamber	1.5	2.0	3.2	-1.1	0.0	1.5	-1.4	1.8	-1.8
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	-0.2	-0.2	0.5	-0.3	-0.1	0.1
Fecal boli incidents, locomotor time 1	0.1	0.3	0.5	0.4	-0.7	0.1	0.1	-0.7	0.7
Change in fecal boli incidents, locomotor task	2.8	3.0	4.5	-1.3	1.8	1.2	-1.9	1.9	-2.1
Time >=10cm from walls, locomotor time 1	0.9	1.1	1.6	-1.1	0.6	1.0	-1.2	1.0	-1.1
Bouts of movement, locomotor time 1	0.7	0.9	2.2	-0.2	-0.9	-0.2	0.8	-1.4	1.5
Total resting periods, locomotor time 1	0.8	0.9	2.0	0.0	-1.0	-0.3	0.8	-1.3	1.4
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.1	-0.4	0.6	-0.4	0.5	-0.3
Distance moved, locomotor task time 1	0.3	0.7	1.2	-0.8	1.1	0.5	-0.9	0.8	-0.9
Vertical activity count, locomotor time 1	0.0	0.3	1.1	0.2	1.0	-0.3	-0.3	0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.7	2.1	3.6	-0.3	0.4	1.6	-1.9	1.8	-1.8
Bouts of movement, locomotor time 2	0.1	0.2	0.8	-0.9	-0.2	0.4	-0.1	-0.4	0.4
Total resting periods, locomotor time 2	0.1	0.3	1.1	-1.0	-0.2	0.5	-0.2	-0.3	0.4
Rest time, locomotor task time 2	0.3	0.5	1.8	-1.3	0.6	0.7	-0.6	0.4	-0.1
Distance moved, locomotor task time 2	0.1	0.2	0.8	0.9	-0.2	-0.4	0.3	0.2	-0.2
Vertical activity count, locomotor time 2	0.5	1.1	3.0	1.7	-0.5	-1.2	1.1	-0.4	0.4
Light reinforcement 1	0.3	1.2	1.8	-1.2	0.2	1.4	-1.3	0.9	-1.0
Light reinforcement 2	0.3	0.6	1.2	-0.9	0.7	0.8	-1.1	0.5	-0.4
Bone: marrow area	0.2	0.6	1.9	1.4	-1.0	0.2	0.1	0.5	-0.3
Bone: maximum diameter	0.1	0.3	0.5	-0.7	-0.3	0.7	-0.4	0.5	-0.4
Bone: maximum force	0.1	0.2	0.5	0.7	-0.6	0.4	-0.0	0.0	0.1
Bone: maximum moment	0.1	0.2	0.4	0.4	-0.2	0.6	-0.4	0.3	-0.2
Mean time between licks in bursts	1.0	6.2	8.8	3.0	-1.7	-2.4	2.8	-2.5	2.5
Mean num. licks in bursts	0.1	0.4	0.5	-0.6	0.2	0.7	-0.7	0.7	-0.7
Cd content in liver	0.7	0.8	3.9	-0.4	-2.0	0.7	0.2	0.1	-0.0
Co content in liver	0.3	0.4	0.7	-0.3	-0.4	0.8	-0.8	0.7	-0.6
Cu content in liver	3.6	4.3	6.9	-1.6	-0.5	2.4	-2.2	2.3	-2.6
Fe content in liver	0.4	0.5	0.9	-0.3	-0.2	1.0	-0.9	0.8	-0.7
K content in liver	0.8	0.8	1.2	-1.0	0.4	1.0	-1.1	0.8	-0.8
Mg content in liver	1.4	1.6	2.5	-0.8	0.9	1.3	-1.6	1.4	-1.4
Mn content in liver	0.1	0.1	0.1	0.3	0.3	-0.4	0.2	-0.0	0.1
Na content in liver	0.9	1.0	1.4	-1.0	0.5	1.0	-1.0	1.2	-1.0
Rb content in liver	0.5	0.6	2.8	0.6	1.7	-0.6	-0.2	0.2	-0.2
Se content in liver	0.4	0.5	1.2	-0.2	-1.1	0.9	-0.5	0.7	-0.6
Sr content in liver	0.4	0.3	0.7	-0.2	0.5	0.4	-0.6	0.7	-0.8
Zn content in liver	0.6	0.7	1.0	-0.8	-0.4	1.0	-0.9	1.0	-1.0
Bone: minimum diameter	0.4	0.8	2.4	1.5	-1.2	-0.4	0.8	0.3	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.4	0.0	0.0	-0.0	-0.4	0.5
Time in novel zone, hab. session 1	0.8	0.8	2.9	-0.9	1.7	0.1	-0.7	0.6	-0.7
Total zone transitions, hab. session 1	0.5	0.6	1.9	0.7	1.4	-0.5	-0.2	-0.9	0.7
Total locomotion distance, hab. session 1	1.1	1.6	3.9	0.5	2.0	-0.9	0.1	-1.5	1.5
Locomotion velocity, hab. session 1	1.1	1.6	2.8	1.0	1.7	-1.0	0.2	-1.5	1.5
Time in familiar zone, hab. session 2	0.1	0.2	0.7	-0.3	-0.9	0.1	0.3	-0.0	-0.0
Time in novel zone, hab. session 2	2.2	2.4	5.8	-0.9	2.4	1.2	-2.2	0.9	-0.9
Total zone transitions, hab. session 2	1.6	2.1	4.0	-1.4	-0.1	2.0	-1.8	1.2	-1.2
Total locomotion distance, hab. session 2	0.6	0.7	1.8	-0.6	0.8	1.1	-1.3	0.4	-0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.9	-0.5	0.4	0.8	-0.9	0.3	-0.3
Novel to familiar place preference ratio	2.0	2.6	13.3	-0.7	3.6	-0.1	-1.3	-0.2	0.2
Novelty place preference	2.4	3.1	15.9	-0.8	4.0	-0.0	-1.5	-0.1	0.1
Time in novel zone, NPP test	3.2	3.9	18.3	-1.1	4.3	0.3	-1.9	0.3	-0.3
Total zone transitions, NPP test	0.9	1.3	2.5	-0.9	-1.1	1.6	-1.1	1.1	-1.1
Total locomotion distance, NPP test	0.3	0.4	0.9	-0.6	-0.7	0.9	-0.6	0.4	-0.4
Locomotion velocity, NPP test	0.3	0.4	0.9	-0.3	-0.9	0.7	-0.4	0.5	-0.5
Intraocular pressure	0.2	0.3	0.8	0.2	-0.6	-0.1	0.3	-0.8	0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.3	-0.1	0.1	-0.1	0.6	-0.7
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	0.4	0.3	-0.9	0.7	-0.3	0.2
Parametrial fat weight	1.7	4.0	5.1	2.3	-1.1	-1.9	2.2	-2.2	2.0
Pavlov. Cond. lever latency	2.4	3.0	4.4	-2.1	1.8	1.2	-1.7	1.8	-1.7
Pavlov. Cond. magazine entry latency	0.9	1.1	3.2	1.8	-0.7	-1.1	1.1	-0.4	0.5
Pavlov. Cond. change in total contacts	2.8	3.0	4.2	1.3	-1.8	-1.4	2.0	-1.8	1.9
Pavlov. Cond. index score	1.5	1.9	3.3	1.8	-1.5	-1.0	1.4	-1.1	1.1
Pavlov. Cond. latency score	1.8	2.3	3.6	1.9	-1.8	-1.0	1.6	-1.3	1.3
Pavlov. Cond. lever contacts	3.6	4.3	5.4	2.3	-2.0	-1.5	2.1	-2.2	2.2
Pavlov. Cond. magazine entry number	0.8	1.0	2.3	-1.5	0.7	1.2	-1.3	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	-0.5	-1.1	1.1	-0.6	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.4	1.9	-1.6	-1.2	1.7	-1.4	1.4
Pavlov. Cond. response bias	1.0	1.2	2.9	1.7	-0.8	-1.1	1.2	-0.8	0.8
Pavlov. Cond. lever latency	0.8	1.1	2.4	1.0	-0.9	-1.2	1.5	-0.6	0.7
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.5	-0.5	0.6	-0.4	-0.0	-0.2
Pavlov. Cond. change in total contacts	0.7	1.6	2.9	-0.1	0.0	1.5	-1.7	1.5	-1.6
Pavlov. Cond. index score	0.3	0.4	1.1	-0.3	0.2	0.9	-1.1	0.4	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.7	-0.3	0.0	0.8	-0.8	0.3	-0.4
Pavlov. Cond. lever contacts	0.7	1.0	2.1	-1.0	0.9	1.1	-1.5	0.4	-0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	0.1	-0.2	-0.7	0.8	-0.4	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.5	1.2	0.1	0.2	0.5	-0.5	1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	1.2	-0.3	0.1	1.0	-1.1	0.5	-0.6
Pavlov. Cond. response bias	0.5	0.7	1.8	-0.6	0.6	1.1	-1.3	0.5	-0.7
Time in closed arm before self-admin	0.3	0.6	1.5	-0.5	-0.8	-0.8	1.2	-0.6	0.3
Time in closed arm after self-admin	0.4	0.4	0.9	-0.6	0.5	-0.4	0.4	-1.0	0.9
Time in open arm before self-admin	0.7	0.8	3.8	0.4	1.9	-0.1	-0.7	-0.5	0.4
Time in open arm after self-admin	1.4	1.6	3.3	-0.2	0.8	1.0	-1.5	1.8	-1.5
Bone: periosteal estimation	0.2	0.4	1.3	1.1	-0.7	-0.1	0.4	0.4	-0.2
Bone: periosteal perimeter	0.1	0.1	0.3	-0.3	-0.5	0.5	-0.2	0.2	-0.0
Bone: post-yield work	0.3	0.5	1.6	0.7	-1.3	0.2	0.2	-0.6	0.7
Progressive ratio test 1 active lever presses	0.5	0.9	2.1	-0.2	-1.4	1.2	-0.7	0.8	-0.7
Progressive ratio test 1 breakpoint	0.5	0.8	2.1	-0.2	-1.5	1.2	-0.7	0.8	-0.6
Progressive ratio test 1 inactive lever presses	0.4	0.9	1.6	1.0	-1.3	-0.5	0.9	-0.9	1.0
Progressive ratio test 2 active lever presses	1.8	2.6	4.3	-0.5	-1.4	1.8	-1.3	2.0	-2.1
Progressive ratio test 2 breakpoint	2.0	2.6	4.5	-0.5	-1.3	1.7	-1.3	2.1	-2.1
Progressive ratio test 2 inactive lever presses	0.1	0.3	1.6	0.3	-1.3	0.3	0.1	0.1	-0.2
Incentive Sensitization - Responses	0.4	1.1	2.0	1.0	-1.2	0.4	-0.1	1.4	-1.4
Incentive Sensitization - Breakpoint	0.5	1.1	2.1	1.0	-1.2	0.4	-0.1	1.4	-1.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.8	1.3	0.1	-0.7	0.4	-0.8	0.6
Progressive ratio	0.7	1.9	2.4	-1.6	1.2	1.1	-1.5	1.4	-1.4
Food seeking constrained by brief footshock	2.5	3.1	5.8	2.2	1.0	-2.4	1.8	-1.3	1.3
Seeking ratio, punishment vs. effort	1.8	3.9	6.4	2.5	-0.0	-2.3	2.1	-1.9	1.9
Retroperitoneal fat weight	0.1	0.4	2.1	1.4	0.1	-0.4	0.2	0.1	-0.4
Reaction time number correct	0.2	0.6	2.4	-0.6	-1.6	0.6	0.1	0.4	-0.1
Reaction time mean minus median	0.8	5.3	9.0	3.0	-0.1	-2.5	2.2	-2.4	2.3
Reaction time mean minus median AUC	0.5	3.0	4.4	2.1	0.3	-1.8	1.5	-2.0	2.0
Reaction time num false alarms	0.7	1.2	2.8	-0.5	1.0	1.2	-1.7	1.0	-0.8
Reaction time num false alarms AUC	0.4	1.0	2.0	-0.7	0.4	1.3	-1.4	1.0	-0.8
Reaction time trials correct on left	0.2	0.6	2.4	-0.6	-1.6	0.6	0.1	0.4	-0.1
Reaction time trials on left	0.2	0.6	2.7	-0.5	-1.6	0.6	0.2	0.3	-0.0
Reaction time mean	2.7	5.9	13.6	3.7	-0.9	-2.5	2.4	-2.2	2.0
Reaction time mean AUC	2.7	6.5	14.4	3.8	-0.7	-2.7	2.5	-2.4	2.3
Median of all reaction times	3.3	5.2	12.1	3.5	-0.9	-2.4	2.3	-2.0	1.9
Reaction time omissions	4.1	6.6	13.3	3.6	-0.9	-2.6	2.6	-2.5	2.5
Reaction time false alarm rate	0.7	1.0	2.0	-0.5	1.3	0.8	-1.4	0.7	-0.7
Reaction time premature initiation rate	0.8	1.2	3.9	-2.0	-0.5	1.1	-0.5	0.8	-0.9
Reaction time premature initiations	0.6	1.8	4.9	-2.2	-1.4	1.4	-0.5	1.0	-0.9
Std. dev. reaction times	1.5	5.0	10.7	3.3	-0.1	-2.5	2.1	-2.1	2.0
Reaction time trials completed	0.2	0.6	2.7	-0.5	-1.6	0.6	0.2	0.3	-0.0
Reaction time trials AUC	0.1	0.5	2.5	-0.4	-1.6	0.5	0.3	0.2	0.1
Run reversals in cocaine runway, females	0.3	0.4	2.1	-1.5	0.1	-0.0	0.3	-0.1	0.1
Run reversals in cocaine runway, males	3.2	3.5	7.4	2.7	-1.0	-1.9	2.0	-1.6	1.6
Latency to leave start box in cocaine runway	0.9	1.2	2.8	1.7	0.0	-1.3	1.1	-0.9	0.9
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.0	0.2	-0.2
Latency to leave start box in cocaine runway, M	5.8	5.5	12.7	3.6	0.4	-2.7	2.2	-2.0	2.0
Std. dev. time between licks in bursts	0.2	0.3	1.1	0.7	-1.0	-0.2	0.5	-0.3	0.3
Total sessions with >9 infusions	1.1	1.4	6.8	0.8	-2.6	0.1	0.8	-0.4	0.4
Short access day 1 total inactive lever presses	0.4	0.7	1.1	0.8	-0.9	-0.6	0.8	-1.0	1.0
Short access day 10 total inactive lever presses	0.4	2.7	4.0	0.8	1.8	-2.0	1.4	-1.9	1.8
Short access day 1 total infusions	0.9	1.7	8.1	1.0	-2.8	0.2	0.8	-0.6	0.4
Short access day 10 total infusions	0.6	1.0	5.5	0.1	-2.3	0.5	0.4	0.2	-0.2
Short access total infusions	1.4	2.0	10.8	0.5	-3.3	0.7	0.5	0.3	-0.3
Short access day 1 locomotion	0.2	0.3	0.7	0.0	-0.2	0.8	-0.8	0.5	-0.6
Short access day 10 total locomotion	0.6	2.2	4.6	2.1	0.1	-1.9	1.6	-1.2	1.1
Short access total locomotion	0.2	0.3	1.2	0.4	-1.1	0.3	0.1	0.3	-0.3
One hour access (0.3 mA shock)	1.0	1.2	2.9	0.0	-0.7	0.9	-0.8	1.5	-1.7
Compulsive drug intake	0.4	0.5	1.4	1.2	0.2	-1.0	0.8	-0.3	0.3
One hour access (shock baseline)	0.6	1.5	1.9	-1.1	-1.4	1.4	-0.8	1.3	-1.4
Social response proportion	1.4	1.7	2.9	0.6	-1.4	-0.9	1.4	-1.5	1.7
Social responses	0.2	0.3	0.6	-0.7	0.4	-0.1	0.0	-0.6	0.8
Social time	0.8	1.3	4.1	1.4	-2.0	-0.3	0.9	-0.6	0.6
Soleus weight	3.3	9.7	29.9	0.3	5.5	-2.5	0.4	-3.3	3.3
Bone: stiffness	0.1	0.2	0.6	0.5	-0.8	0.3	0.1	-0.4	0.4
Tibialis anterior weight	0.4	1.4	2.9	1.7	1.7	-0.8	0.1	-0.8	1.0
Time to tail flick, vehicle, before self-admin	0.7	0.9	2.8	0.1	-1.7	-0.0	0.8	-0.9	1.0
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.3	-0.1	-1.1	0.8	-0.4	1.0	-0.8
Time to tail flick, test, before self-admin	1.4	1.6	3.5	0.7	1.9	-1.6	0.8	-1.4	0.7
Time to tail flick, test, after self-admin	1.0	1.1	5.1	-0.7	2.3	-0.8	0.0	-0.4	0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.3	-0.2	0.3	-0.3	0.7	-0.7
Delta time to tail flick, test, before/after SA	0.6	0.8	1.2	-1.1	0.8	0.7	-1.0	1.1	-0.4
Tibia length	1.2	3.2	9.8	-0.9	-3.1	2.1	-0.7	1.3	-1.4
Ambulatory time before self-admin	0.9	2.8	4.0	-1.6	0.2	2.0	-1.9	2.0	-1.8
Ambulatory time after self-admin	0.7	1.1	2.2	-0.9	0.1	0.9	-0.9	1.5	-1.5
Bone: tissue strength	0.1	0.1	0.2	0.3	-0.0	0.3	-0.4	0.4	-0.3
Total heroin consumption	0.6	0.7	3.1	-0.5	1.8	0.1	-0.9	0.2	-0.1
Bone: trabecular number	0.9	1.7	8.0	-0.7	2.8	-0.6	-0.4	-0.9	0.8
Bone: trabecular spacing	2.6	3.9	6.1	-0.7	-2.4	2.0	-1.2	2.5	-2.4
Bone: trabecular thickness	2.9	4.0	8.3	0.6	-0.0	-2.0	2.0	-2.7	2.9
Bone: trabecular tissue density	1.9	3.3	5.4	0.2	-2.3	-1.0	2.0	-2.2	2.1
Water consumed over 24 hours	0.7	1.3	2.3	-0.6	0.0	1.3	-1.2	1.5	-1.5
Number of responses in last shaping day	1.0	1.3	1.8	-1.2	-0.1	1.3	-1.3	1.2	-1.2