Hub : Genes

Tmtc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Tmtc2 0.13 0.05 1.3e-11 0.12 0.1 0.11 0.11 7.5e-14 4.4e-12 2.5e-12 1.4e-12
2 PL gene expression Tmtc2 0.05 0.03 3.2e-03 0.01 0.02 0.01 0.02 6.1e-02 2.1e-03 1.5e-02 2.9e-03
3 Liver gene expression Tmtc2 0.15 0.08 4.6e-11 0.09 0.09 0.09 0.1 2.6e-10 1.7e-10 6.4e-10 9.8e-11
4 Adipose gene expression Tmtc2 0.12 0.05 6.6e-09 0.08 0.07 0.08 0.09 3.1e-09 2.7e-08 2.0e-09 6.0e-10
5 BLA gene expression Tmtc2 0.21 0.08 2.8e-08 0.12 0.15 0.17 0.17 5.7e-07 3.3e-08 3.2e-09 3.2e-09
6 Brain gene expression Tmtc2 0.14 0.06 1.1e-11 0.12 0.14 0.14 0.14 2.3e-11 7.2e-13 4.1e-13 4.0e-13
7 Adipose alternative polyA NM_001171177.2 0.05 0.03 4.5e-03 0.01 0.01 0 0.01 7.0e-02 2.9e-02 9.0e-02 3.7e-02
8 Adipose isoform ratio XM_039078707.1 0.03 0.02 7.9e-03 0 0.01 0 0 3.4e-01 3.3e-02 9.8e-02 8.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.5-0.70.1-0.2-0.10.00.40.20.5
Area under the delay curve2.22.34.9-1.52.21.81.11.61.51.30.5
BMI with tail0.61.95.42.3-1.6-1.00.4-1.2-1.1-0.9-1.6
BMI without tail0.40.83.11.10.51.01.80.10.4-0.1-1.0
Body weight0.10.51.91.4-0.4-0.70.8-0.30.20.60.0
Weight adjusted by age0.10.20.40.1-0.6-0.3-0.4-0.6-0.4-0.1-0.4
Bone surface0.30.61.00.00.30.9-1.0-0.9-0.6-0.7-0.9
Bone volume0.10.10.5-0.20.10.3-0.5-0.7-0.2-0.3-0.4
Breakpoint value in progressive ratio session2.52.75.9-0.60.5-1.32.01.01.82.42.3
Number of licking bursts0.50.61.4-0.21.20.90.60.71.00.60.4
Context. condit. distance diff. score1.51.85.5-2.32.01.6-0.11.21.0-0.10.5
Locomotion velocity, session 10.80.93.01.0-0.4-0.71.70.70.80.90.6
Locomotion distance, session 10.50.62.71.20.00.11.60.40.60.1-0.4
Locomotion velocity, session 20.50.61.51.20.31.10.7-0.3-0.2-0.6-1.1
Locomotion distance, session 20.81.14.72.2-0.50.31.3-0.6-0.2-0.5-1.2
Locomotion velocity, session 31.21.42.2-1.11.20.41.51.41.50.91.1
Locomotion distance, session 32.93.25.4-1.72.31.61.82.22.11.01.1
Stereotopy head waving bouts, day 30.10.10.40.20.2-0.10.3-0.70.3-0.2-0.1
Stereotopy head waving duration, day 30.50.61.71.0-0.8-0.7-0.1-1.3-0.5-0.5-0.5
Locomotion velocity, session 71.31.42.1-1.31.51.11.11.21.40.90.8
Locomotion distance, session 70.91.22.6-1.61.51.40.51.11.00.30.3
Stereotopy head waving bouts, day 71.11.22.2-0.21.50.81.40.71.51.40.6
Stereotopy head waving duration, day 71.21.53.2-0.81.81.21.11.01.51.20.7
Locomotion velocity, session 80.20.20.70.6-0.8-0.80.10.1-0.3-0.10.2
Locomotion distance, session 80.71.01.9-1.11.41.10.91.31.10.20.4
Degree of sensitization distance0.60.61.6-0.3-0.6-0.1-1.3-1.0-1.0-0.6-0.6
Degree of sensitization stereotypy0.91.02.2-0.11.51.01.10.71.21.10.3
Conditioned locomotion0.80.92.30.5-0.9-1.0-1.2-1.5-0.9-0.4-0.4
Cocaine response after cond. corrected0.60.73.0-0.61.21.7-0.20.2-0.10.0-0.7
Cocaine response after cond. not corrected1.11.24.6-1.31.62.10.00.80.20.2-0.5
Cocaine response before conditioning0.70.92.2-1.50.90.70.61.40.90.40.6
Saline control response0.40.61.8-0.4-0.0-0.70.50.30.71.41.1
Bone: connectivity density0.10.20.6-0.80.50.5-0.4-0.20.2-0.1-0.0
Bone: cortical apparent density4.05.27.9-2.32.71.61.82.82.72.21.9
Bone: cortical area0.81.24.3-0.61.62.10.70.80.7-0.2-0.4
Bone: cortical porosity1.41.53.51.1-1.9-1.5-0.9-1.0-1.6-0.9-0.5
Bone: cortical porosity1.71.84.61.1-2.1-1.9-0.9-0.9-1.6-0.7-0.2
Bone: cortical thickness1.21.94.8-1.42.22.11.01.21.30.30.2
Bone: cortical thickness2.42.75.3-1.91.81.21.42.32.00.81.3
Bone: cortical tissue density3.85.07.3-2.32.61.51.72.72.72.21.9
Condit. Reinf. active minus inactive responses0.30.41.70.5-0.9-1.3-0.4-0.4-0.3-0.10.4
Condit. Reinf. active-inactive response ratio0.10.10.4-0.3-0.3-0.6-0.50.3-0.1-0.10.4
Condit. Reinf. active responses0.30.31.20.5-0.7-1.1-0.1-0.6-0.20.10.3
Condit. Reinf. inactive responses0.40.52.00.20.3-0.11.40.00.90.90.5
Incentive salience index mean1.01.33.01.2-1.7-1.7-0.8-1.1-1.0-0.4-0.0
Condit. Reinf. lever presses1.72.34.42.0-2.1-1.6-1.0-1.6-1.6-0.7-0.8
Condit. Reinf. active minus inactive responses1.41.74.2-0.11.00.82.11.81.51.10.9
Condit. Reinf. active-inactive response ratio1.61.74.5-0.30.80.32.11.71.51.31.2
Condit. Reinf. active responses0.40.51.30.30.50.51.11.10.70.60.5
Condit. Reinf. inactive responses0.10.10.30.10.20.4-0.60.0-0.2-0.4-0.3
Condit. Reinf. lever presses0.10.10.3-0.20.30.40.30.50.3-0.00.2
Condit. Reinf. lever reinforcers received0.40.61.50.20.70.81.21.20.80.60.3
Conditioned reinforcement - actives0.80.81.71.3-0.30.3-0.8-1.0-0.8-1.1-0.9
Conditioned reinforcement - inactives0.40.51.60.10.10.6-1.1-0.4-0.6-1.3-0.5
Conditioned locomotion0.10.20.60.40.40.5-0.3-0.10.1-0.8-0.4
Patch foraging indifference point 0 sec0.61.03.3-0.3-0.7-0.1-1.8-0.9-1.3-1.0-0.6
Patch foraging indifference point AUC0.70.93.8-0.5-0.10.1-2.0-0.6-1.0-1.0-0.7
Delay disc. indifference point, 0s delay0.80.92.2-0.10.41.1-1.0-1.1-0.7-1.1-1.5
Delay disc. indifference point, 16s delay3.73.88.8-1.63.02.21.82.02.11.50.6
Delay disc. indifference point, 2s delay0.30.41.6-1.30.40.20.00.60.30.70.3
Delay disc. indifference point, 24s delay2.82.76.6-1.12.62.11.41.91.80.60.1
Delay disc. indifference point, 4s delay0.10.10.4-0.40.00.1-0.6-0.3-0.50.0-0.1
Delay disc. indifference point, 8s delay1.92.05.0-1.12.22.11.01.51.20.90.2
Indifference point function ln k0.91.24.20.60.60.12.10.81.21.40.9
Indifference point function log k0.91.24.20.60.60.12.10.81.21.40.9
Patch foraging total patch changes 0 sec0.40.62.7-0.5-0.4-0.0-1.7-0.6-1.0-0.7-0.3
Patch foraging total patch changes 12 sec1.01.34.3-1.20.31.0-2.1-0.4-1.0-1.3-0.9
Patch foraging total patch changes 18 sec0.60.73.6-1.10.20.0-1.9-0.2-0.7-0.6-0.2
Patch foraging total patch changes 24 sec0.40.51.0-0.20.40.8-1.0-0.2-0.3-1.0-0.9
Patch foraging total patch changes 6 sec0.60.83.4-0.5-0.00.6-1.8-0.1-1.0-1.1-0.7
Patch foraging time to switch 0 sec0.10.10.3-0.4-0.20.20.10.3-0.3-0.6-0.5
Patch foraging water rate 0 sec0.20.41.0-0.51.00.60.00.60.70.50.6
Patch foraging water rate 12 sec0.50.83.10.90.60.51.80.21.00.80.1
Patch foraging water rate 18 sec0.71.02.90.30.1-0.31.70.11.21.51.0
Patch foraging water rate 24 sec2.23.06.0-0.92.11.72.41.72.01.60.6
Patch foraging water rate 6 sec1.01.56.00.60.50.12.41.11.51.20.9
Seeking ratio, delayed vs. immediate footshock0.50.61.9-0.21.11.40.50.80.5-0.3-0.2
Distance traveled before self-admin0.60.61.2-1.11.11.00.50.20.90.60.3
Distance traveled after self-admin0.10.20.70.6-0.1-0.0-0.2-0.8-0.2-0.2-0.3
Extensor digitorum longus weight0.21.02.90.9-1.7-1.7-0.2-0.8-0.7-0.20.1
Bone: elastic displacement0.30.30.7-0.4-0.2-0.60.40.80.50.10.8
Bone: elastic work0.30.41.10.20.30.11.00.80.90.20.5
Bone: endosteal estimation0.20.50.90.9-0.9-0.4-0.6-0.5-0.9-0.7-0.7
Bone: endosteal perimeter0.10.20.30.5-0.10.3-0.5-0.1-0.5-0.4-0.5
Epididymis fat weight0.20.51.7-0.91.01.3-0.00.60.10.2-0.2
Delta time in closed arm before/after self-admin0.80.82.8-0.7-0.9-1.7-1.1-0.5-0.50.10.5
Delta time in open arm before/after self-admin0.20.20.7-0.6-0.0-0.10.1-0.10.40.80.8
Diff in mean of infusions in LGA sessions3.94.37.2-1.50.7-1.42.52.32.22.52.7
Delay discount exponential model param2.32.44.61.4-2.1-1.6-1.4-1.8-1.6-1.4-0.7
Extinction: sum of active levers before priming1.71.73.40.8-1.4-1.6-1.8-1.5-1.4-0.6-0.2
Active lever presses in extinction session 60.80.82.5-0.7-0.5-1.40.00.30.60.61.6
Bone: final force0.50.92.9-0.71.11.7-0.80.3-0.0-1.0-0.7
Bone: final moment0.50.83.0-0.71.11.7-0.60.30.1-0.9-0.8
Food consumed during 24 hour testing period0.10.10.30.5-0.6-0.40.1-0.1-0.2-0.5-0.2
Glucose0.30.41.50.00.91.20.3-0.30.2-0.3-0.7
Heart weight0.81.23.40.80.2-0.81.80.21.41.41.0
Delay discount hyperbolic model param1.82.03.61.5-1.9-1.4-1.1-1.6-1.4-1.3-0.6
Intermittent access intake day 1-15 change0.20.20.80.10.30.9-0.20.1-0.4-0.5-0.7
Intermittent access intake escalation0.30.31.0-0.20.51.0-0.20.3-0.3-0.3-0.6
Intermittent access intake escalation 20.10.10.40.6-0.20.40.30.2-0.4-0.1-0.4
Intermitt. access day 1 inactive lever presses0.40.40.9-0.6-0.20.3-1.0-0.7-0.7-0.6-0.6
Intermitt. access day 15 inactive lever presses0.91.03.00.4-1.7-1.3-0.8-0.8-1.2-0.2-0.3
Intermitt. access escalation Index0.40.30.80.7-0.2-0.60.90.70.50.30.3
Intermittent access day 1 total infusions0.50.61.30.11.01.2-0.7-0.6-0.0-1.0-0.7
Intermittent access day 15 total infusions0.70.82.7-0.10.91.6-0.8-0.3-0.4-1.1-0.9
Intermittent access terminal intake (last 3 days)0.91.01.80.70.11.0-1.0-0.9-0.9-1.4-1.3
Intermittent access total infusions0.80.91.70.60.51.2-1.1-1.0-0.6-1.3-1.1
Intermittent access day 1 locomotion0.70.82.1-1.01.51.4-0.60.30.5-0.7-0.1
Intermittent access day 15 total locomotion1.41.54.1-2.01.91.5-0.21.11.0-0.20.4
Intermittent access total locomotion0.80.92.5-1.21.61.4-0.40.50.7-0.6-0.1
Intermittent access standard deviation0.70.71.50.7-0.40.7-0.6-1.0-0.9-1.0-1.2
Left kidney weight1.02.77.4-0.50.5-0.92.00.82.02.72.1
Right kidney weight0.51.52.7-1.11.40.31.00.91.61.61.4
Cocaine induced anxiety2.63.07.40.6-1.8-0.6-2.7-1.4-2.5-1.6-1.3
Post-drug Anxiety2.83.15.61.4-1.8-0.8-2.0-2.1-2.4-1.3-1.6
Baseline Anxiety2.02.25.3-0.21.50.42.30.62.01.91.2
Tail length1.54.58.7-1.62.92.12.12.02.61.71.4
Length with tail0.31.22.3-0.61.50.80.50.91.41.41.3
Length without tail0.30.61.70.5-0.7-1.1-1.3-0.6-0.60.00.3
Times rat made contact with spout0.91.12.61.6-1.5-1.60.3-1.0-0.30.10.1
Lifetime Intake1.11.32.50.50.71.4-1.1-1.1-0.6-1.6-1.4
Liver weight, left0.81.33.61.60.51.50.5-1.0-0.3-0.8-1.9
Liver weight, right0.50.72.60.9-0.2-0.61.60.20.71.10.5
Locomotor activity0.20.30.7-0.30.50.20.80.70.80.30.4
Locomotor testing distance0.20.40.7-0.50.80.70.70.80.70.00.1
Locomotor testing rearing0.20.41.1-1.10.60.60.10.80.60.00.4
Locomotion in novel chamber3.24.08.9-1.93.02.21.32.22.41.01.2
Locomotion in novel chamber post-restriction0.10.10.3-0.20.10.2-0.10.30.2-0.50.1
Fecal boli incidents, locomotor time 10.60.71.8-0.9-0.2-0.70.00.50.41.31.4
Change in fecal boli incidents, locomotor task1.21.12.0-0.91.41.01.01.31.40.40.7
Time >=10cm from walls, locomotor time 10.20.20.30.5-0.40.1-0.4-0.4-0.5-0.3-0.3
Bouts of movement, locomotor time 11.92.13.5-1.01.40.21.41.71.71.91.6
Total resting periods, locomotor time 10.70.81.9-0.60.7-0.10.90.81.01.41.1
Rest time, locomotor task time 10.10.10.20.1-0.4-0.5-0.2-0.1-0.3-0.1-0.0
Distance moved, locomotor task time 10.10.10.3-0.20.20.50.10.30.0-0.3-0.2
Vertical activity count, locomotor time 10.30.30.7-0.60.50.40.30.80.40.40.5
Time >=10cm from walls, locomotor time 20.20.20.50.7-0.6-0.4-0.1-0.7-0.2-0.0-0.1
Bouts of movement, locomotor time 20.10.10.60.1-0.2-0.50.7-0.10.30.40.2
Total resting periods, locomotor time 20.10.10.50.2-0.3-0.70.4-0.20.00.20.0
Rest time, locomotor task time 20.20.30.9-0.7-0.1-1.0-0.30.2-0.00.60.6
Distance moved, locomotor task time 20.40.51.40.70.21.20.4-0.4-0.1-0.7-1.1
Vertical activity count, locomotor time 20.50.51.9-0.00.81.40.70.70.5-0.2-0.2
Light reinforcement 10.81.42.31.4-1.4-0.9-0.8-1.5-1.1-0.9-1.1
Light reinforcement 20.71.02.71.2-1.4-1.6-0.1-1.1-0.50.30.3
Bone: marrow area0.20.50.70.8-0.8-0.3-0.6-0.5-0.8-0.7-0.7
Bone: maximum diameter0.30.51.11.00.20.90.0-0.8-0.4-0.5-0.9
Bone: maximum force0.40.72.5-0.61.11.6-0.40.30.2-0.7-0.6
Bone: maximum moment0.40.72.7-0.51.21.7-0.20.20.3-0.6-0.7
Mean time between licks in bursts1.82.64.3-0.51.81.22.11.92.01.41.3
Mean num. licks in bursts0.80.92.60.7-1.6-1.5-0.1-1.0-0.9-0.2-0.2
Cd content in liver0.60.61.90.1-0.50.2-1.0-0.3-0.9-1.4-0.9
Co content in liver0.20.20.5-0.20.40.70.40.20.2-0.3-0.5
Cu content in liver0.40.41.51.10.20.21.20.40.50.5-0.0
Fe content in liver1.21.42.71.4-1.7-1.0-0.8-0.4-1.6-1.3-0.8
K content in liver2.52.56.52.3-1.9-2.61.1-1.1-0.11.10.7
Mg content in liver0.90.92.51.6-1.3-1.0-0.1-1.2-0.7-0.4-0.5
Mn content in liver0.10.20.50.4-0.20.40.1-0.2-0.1-0.7-0.6
Na content in liver1.51.55.32.3-1.4-0.9-0.2-1.6-1.0-0.4-0.8
Rb content in liver0.60.81.70.7-0.20.3-0.7-1.3-1.0-1.0-1.3
Se content in liver0.20.20.50.70.20.7-0.2-0.0-0.5-0.5-0.6
Sr content in liver0.10.10.30.00.20.50.30.30.1-0.3-0.3
Zn content in liver0.91.03.01.7-1.5-1.2-0.1-0.7-0.9-0.4-0.4
Bone: minimum diameter0.50.93.9-0.11.42.00.20.90.2-0.4-0.7
Time in familiar zone, hab. session 11.11.03.90.9-1.5-2.00.3-0.2-0.20.50.9
Time in novel zone, hab. session 11.11.13.5-1.31.51.9-0.40.20.1-0.6-0.8
Total zone transitions, hab. session 10.60.82.11.4-0.9-1.01.40.20.30.50.4
Total locomotion distance, hab. session 10.71.03.01.7-0.9-1.41.20.10.40.80.7
Locomotion velocity, hab. session 10.71.13.61.9-1.0-1.21.2-0.20.40.80.5
Time in familiar zone, hab. session 20.80.82.6-0.20.60.31.60.71.21.00.8
Time in novel zone, hab. session 21.11.12.30.4-0.6-0.1-1.5-0.8-1.3-1.5-1.2
Total zone transitions, hab. session 20.20.30.80.9-0.5-0.10.60.7-0.1-0.5-0.5
Total locomotion distance, hab. session 20.30.41.21.1-0.6-0.80.60.80.30.10.2
Locomotion velocity, hab. session 20.30.41.21.1-0.6-0.80.50.60.30.20.2
Novel to familiar place preference ratio0.50.51.80.0-0.30.1-1.3-0.4-0.9-0.8-0.7
Novelty place preference0.30.31.3-0.1-0.3-0.1-1.1-0.2-0.7-0.5-0.3
Time in novel zone, NPP test0.20.20.9-0.30.00.1-0.90.1-0.5-0.3-0.2
Total zone transitions, NPP test0.20.31.11.0-0.7-0.30.40.5-0.4-0.4-0.5
Total locomotion distance, NPP test0.60.93.82.0-1.0-1.01.00.5-0.00.10.0
Locomotion velocity, NPP test0.60.93.21.8-1.1-1.30.80.4-0.10.10.2
Intraocular pressure0.71.02.8-1.31.41.7-0.60.30.1-0.9-0.7
Delta distance traveled before/after self-admin0.20.20.50.6-0.5-0.7-0.2-0.2-0.3-0.2-0.0
Delta ambulatory time before/after self-admin1.41.62.51.4-1.0-0.5-1.3-1.1-1.5-1.6-1.3
Parametrial fat weight0.20.51.11.00.70.71.0-0.20.60.4-0.1
Pavlov. Cond. lever latency0.20.20.7-0.00.10.6-0.20.1-0.3-0.8-0.6
Pavlov. Cond. magazine entry latency0.40.61.3-1.20.80.30.50.70.60.90.7
Pavlov. Cond. change in total contacts0.10.10.7-0.80.20.0-0.10.50.00.20.2
Pavlov. Cond. index score0.81.12.4-0.80.9-0.01.11.01.21.51.1
Pavlov. Cond. latency score0.50.71.7-0.60.6-0.20.80.60.91.31.0
Pavlov. Cond. lever contacts0.20.20.80.0-0.2-0.70.40.10.20.90.6
Pavlov. Cond. magazine entry number1.72.13.21.7-1.4-0.3-1.3-1.4-1.6-1.8-1.4
Pavlov. Cond. intertrial magazine entries0.30.30.9-0.4-0.4-0.9-0.50.5-0.10.31.0
Pavlov. Cond. lever-magazine prob. diff.0.50.71.5-0.50.80.10.90.81.01.20.8
Pavlov. Cond. response bias0.50.61.5-0.60.80.20.70.50.81.20.6
Pavlov. Cond. lever latency0.20.31.10.5-0.9-1.10.0-0.2-0.3-0.10.0
Pavlov. Cond. magazine entry latency1.31.53.2-1.31.81.41.00.61.21.40.7
Pavlov. Cond. change in total contacts1.11.63.1-1.11.71.51.11.21.31.10.7
Pavlov. Cond. index score0.91.22.5-1.11.61.20.70.81.11.10.7
Pavlov. Cond. latency score1.11.42.5-1.11.61.10.90.81.21.50.9
Pavlov. Cond. lever contacts0.20.30.7-0.50.80.80.20.20.40.40.2
Pavlov. Cond. magazine entry number2.12.66.61.8-2.6-2.0-0.9-1.1-1.7-1.3-0.8
Pavlov. Cond. intertrial magazine entries0.81.02.00.6-1.0-0.3-1.3-0.6-1.4-1.3-1.0
Pavlov. Cond. lever-magazine prob. diff.1.11.43.0-1.31.71.30.80.91.21.30.9
Pavlov. Cond. response bias0.60.82.6-0.81.51.60.40.40.80.4-0.0
Time in closed arm before self-admin0.91.03.0-0.71.51.70.71.00.80.40.0
Time in closed arm after self-admin0.20.20.5-0.70.2-0.3-0.10.50.20.70.6
Time in open arm before self-admin0.50.51.00.6-1.0-0.9-0.5-0.8-0.6-0.7-0.3
Time in open arm after self-admin0.20.20.5-0.1-0.7-0.6-0.4-0.6-0.20.10.5
Bone: periosteal estimation0.10.20.70.30.40.80.30.20.0-0.4-0.5
Bone: periosteal perimeter0.20.31.6-0.10.81.30.10.2-0.1-0.3-0.6
Bone: post-yield work0.40.51.60.80.30.6-0.2-1.3-0.2-0.5-1.0
Progressive ratio test 1 active lever presses0.20.31.1-0.41.00.60.10.00.70.00.2
Progressive ratio test 1 breakpoint0.20.20.8-0.20.90.40.2-0.20.70.00.1
Progressive ratio test 1 inactive lever presses0.30.40.9-0.10.61.0-0.1-0.70.0-0.7-0.8
Progressive ratio test 2 active lever presses0.60.71.50.9-0.2-0.0-0.9-1.0-0.7-1.2-0.8
Progressive ratio test 2 breakpoint0.50.61.50.8-0.10.1-0.9-0.8-0.6-1.2-0.7
Progressive ratio test 2 inactive lever presses0.10.10.40.3-0.00.0-0.7-0.4-0.4-0.6-0.2
Incentive Sensitization - Responses1.21.22.61.0-0.7-0.1-1.4-0.9-1.3-1.6-1.0
Incentive Sensitization - Breakpoint0.91.02.30.8-0.60.0-1.3-0.8-1.2-1.5-1.0
Sum of active levers in priming session hrs 5-62.92.96.1-0.50.7-1.02.11.31.92.52.3
Progressive ratio2.52.98.1-2.22.72.9-0.41.30.8-0.3-0.3
Food seeking constrained by brief footshock1.51.84.7-0.60.1-0.81.51.11.42.21.8
Seeking ratio, punishment vs. effort2.02.55.31.2-1.4-2.31.90.00.82.11.6
Retroperitoneal fat weight0.20.82.1-0.20.4-0.21.40.61.01.40.8
Reaction time number correct2.02.99.73.1-1.6-0.70.1-2.6-1.2-0.7-1.4
Reaction time mean minus median1.11.56.2-1.31.82.5-0.50.6-0.0-0.3-0.6
Reaction time mean minus median AUC1.52.07.1-0.51.32.7-1.3-0.4-0.9-1.2-1.6
Reaction time num false alarms0.71.02.7-0.6-0.5-1.70.80.40.61.21.4
Reaction time num false alarms AUC0.71.02.2-1.0-0.3-1.50.60.60.61.21.5
Reaction time trials correct on left2.02.99.73.1-1.6-0.70.1-2.6-1.2-0.7-1.4
Reaction time trials on left1.92.78.72.9-1.6-0.70.1-2.5-1.2-0.6-1.3
Reaction time mean5.98.225.9-5.13.32.00.23.42.11.82.4
Reaction time mean AUC5.27.021.9-4.73.01.70.33.11.91.82.4
Median of all reaction times8.211.232.2-5.73.61.50.84.12.92.53.3
Reaction time omissions0.70.94.8-2.20.80.5-1.10.8-0.20.20.3
Reaction time false alarm rate1.21.75.0-2.20.3-1.00.41.60.91.11.8
Reaction time premature initiation rate4.35.710.3-1.82.00.13.02.93.22.32.5
Reaction time premature initiations1.62.37.20.20.8-0.42.71.12.21.61.4
Std. dev. reaction times2.84.011.1-3.32.72.40.12.21.10.80.9
Reaction time trials completed1.92.78.72.9-1.6-0.70.1-2.5-1.2-0.6-1.3
Reaction time trials AUC1.82.68.62.9-1.7-0.90.2-2.4-1.1-0.5-1.1
Run reversals in cocaine runway, females0.50.51.2-1.10.91.00.30.90.50.0-0.2
Run reversals in cocaine runway, males0.20.20.6-0.3-0.5-0.7-0.20.1-0.10.50.8
Latency to leave start box in cocaine runway0.70.82.10.50.81.4-0.3-0.8-0.3-0.8-1.4
Latency to leave start box in cocaine runway, F1.01.11.90.8-0.7-0.3-1.4-1.3-1.3-1.0-1.1
Latency to leave start box in cocaine runway, M3.63.48.1-1.62.92.81.51.32.00.90.0
Std. dev. time between licks in bursts0.60.72.2-0.80.3-0.70.10.60.91.01.5
Total sessions with >9 infusions0.91.02.30.50.10.9-1.0-1.0-0.8-1.5-1.3
Short access day 1 total inactive lever presses0.50.61.2-1.10.81.1-1.0-0.2-0.1-0.7-0.2
Short access day 10 total inactive lever presses1.11.24.10.5-1.6-2.00.9-0.10.11.10.8
Short access day 1 total infusions0.40.51.00.30.80.9-0.2-0.9-0.1-0.6-1.0
Short access day 10 total infusions0.91.03.2-0.71.61.8-0.50.10.4-0.9-0.8
Short access total infusions0.60.71.20.50.60.8-0.7-1.1-0.4-1.1-1.1
Short access day 1 locomotion0.70.83.40.31.41.80.50.10.60.2-0.4
Short access day 10 total locomotion1.41.53.1-1.81.71.60.31.31.20.50.5
Short access total locomotion0.20.20.6-0.20.70.80.10.00.50.1-0.1
One hour access (0.3 mA shock)0.60.72.2-0.30.50.7-1.5-0.1-0.5-1.2-0.6
Compulsive drug intake0.20.20.9-0.0-0.6-0.9-0.3-0.1-0.40.10.0
One hour access (shock baseline)0.70.81.8-0.00.61.4-1.3-0.2-0.5-1.2-0.8
Social response proportion1.41.53.9-0.6-0.8-2.00.60.40.71.52.0
Social responses0.50.62.50.7-1.2-1.60.3-0.6-0.1-0.10.4
Social time0.20.20.5-0.70.60.50.10.50.40.30.2
Soleus weight0.82.34.62.1-1.6-0.4-1.0-1.8-1.6-1.5-1.5
Bone: stiffness0.50.82.4-0.51.51.50.50.80.90.1-0.2
Tibialis anterior weight0.10.30.8-0.4-0.5-0.9-0.10.20.00.60.9
Time to tail flick, vehicle, before self-admin1.21.32.0-1.10.4-0.71.31.01.41.21.4
Time to tail flick, vehicle, after self-admin0.90.91.9-0.61.21.21.40.61.10.8-0.1
Time to tail flick, test, before self-admin1.31.35.11.10.2-0.22.30.61.21.30.5
Time to tail flick, test, after self-admin1.51.63.50.41.31.11.91.61.61.00.6
Delta time to tail flick, vehicle, before/after SA0.70.71.50.50.31.2-0.8-0.7-0.8-0.7-1.2
Delta time to tail flick, test, before/after SA0.30.30.9-0.30.60.9-0.30.60.0-0.4-0.4
Tibia length1.02.74.71.0-0.51.3-2.2-1.4-2.2-1.8-2.0
Ambulatory time before self-admin1.01.12.0-1.41.41.30.70.51.20.80.4
Ambulatory time after self-admin0.00.00.20.30.20.1-0.0-0.50.1-0.0-0.0
Bone: tissue strength0.40.41.10.7-1.0-1.0-0.1-0.4-0.40.00.0
Total heroin consumption0.20.31.00.1-0.5-1.00.4-0.20.10.60.6
Bone: trabecular number0.40.62.4-1.60.90.8-0.60.00.3-0.3-0.0
Bone: trabecular spacing1.51.94.91.6-0.21.1-0.5-1.2-1.2-1.7-2.2
Bone: trabecular thickness1.82.24.1-0.3-0.2-1.61.91.01.42.02.0
Bone: trabecular tissue density0.81.22.21.1-0.8-1.51.40.70.51.21.0
Water consumed over 24 hours0.50.61.10.9-0.7-1.11.00.20.50.60.7
Number of responses in last shaping day0.50.61.10.3-0.4-1.00.90.30.70.81.0