Hub : Genes

Tmprss11b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	alternative polyA	NM_001412524.1	0.72	0.12	3.0e-08	0.36	0.31	0.36	0.33	1.8e-06	1.2e-05	1.9e-06	4.8e-06
2	Eye	isoform ratio	NM_001412524.1	0.8	0.08	9.2e-11	0.39	0.37	0.32	0.32	3.8e-07	9.9e-07	7.0e-06	8.1e-06
3	Eye	isoform ratio	XM_063273446.1	0.73	0.1	1.5e-09	0.39	0.35	0.27	0.32	4.0e-07	2.1e-06	5.1e-05	7.4e-06
4	Eye	gene expression	Tmprss11b	0.5	0.18	5.1e-04	0.23	0.29	0.22	0.25	1.9e-04	1.9e-05	2.7e-04	9.7e-05
5	Eye	alternative polyA	XM_063273446.1	0.69	0.12	6.1e-08	0.36	0.3	0.35	0.32	1.7e-06	1.6e-05	2.3e-06	6.1e-06
6	OFC	gene expression	Tmprss11b	0.57	0.19	3.6e-03	0.03	0.06	0.1	0.1	6.9e-02	1.2e-02	2.4e-03	2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.4	0.5	0.5	-0.5	-0.0	-0.6	-0.3
Area under the delay curve	0.2	0.4	0.9	-0.4	-0.4	0.4	0.9	0.0	-0.9
BMI with tail	1.6	5.7	6.9	2.6	2.6	-2.6	2.4	-2.3	-1.7
BMI without tail	0.9	4.7	5.5	2.3	2.3	-2.3	2.3	-2.1	-1.3
Body weight	0.3	1.3	3.7	0.6	0.6	-0.6	1.9	-0.6	-1.6
Weight adjusted by age	0.5	1.6	2.4	1.4	1.4	-1.4	-0.9	-1.5	-0.4
Bone surface	0.1	0.3	1.3	0.3	0.3	-0.3	-1.1	-0.1	0.1
Bone volume	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.3	0.5	0.3
Breakpoint value in progressive ratio session	0.2	0.4	0.6	-0.7	-0.7	0.7	0.0	0.8	0.5
Number of licking bursts	0.1	0.3	1.0	0.5	0.5	-0.5	-0.3	-0.3	-1.0
Context. condit. distance diff. score	1.2	1.4	7.4	-0.1	-0.1	0.1	-2.7	-0.0	1.0
Locomotion velocity, session 1	1.4	1.6	6.8	0.3	0.3	-0.3	1.4	-0.8	-2.6
Locomotion distance, session 1	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.4	0.3	-0.5
Locomotion velocity, session 2	0.0	0.0	0.2	-0.0	-0.0	0.0	-0.5	-0.1	-0.1
Locomotion distance, session 2	0.1	0.1	0.6	-0.1	-0.1	0.1	-0.1	0.1	-0.8
Locomotion velocity, session 3	0.5	0.6	0.8	-0.9	-0.9	0.9	-0.1	0.9	0.4
Locomotion distance, session 3	0.1	0.2	0.6	0.3	0.3	-0.3	-0.1	0.2	0.8
Stereotopy head waving bouts, day 3	0.6	0.7	2.0	0.6	0.6	-0.6	0.6	-0.9	-1.4
Stereotopy head waving duration, day 3	0.5	0.7	3.7	-0.2	-0.2	0.2	0.2	-0.4	-1.9
Locomotion velocity, session 7	1.7	1.9	2.6	-1.6	-1.6	1.6	0.6	1.5	-0.9
Locomotion distance, session 7	1.0	1.3	1.9	-1.4	-1.4	1.4	-0.3	1.4	0.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.2	0.2	-0.2	-0.3	-0.5	-0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.9	0.4	0.4	-0.4	0.9	-0.5	-0.8
Locomotion velocity, session 8	0.2	0.2	1.4	0.1	0.1	-0.1	-1.2	-0.1	0.1
Locomotion distance, session 8	0.8	1.1	6.2	-0.4	-0.4	0.4	-2.5	0.3	0.2
Degree of sensitization distance	1.4	1.5	2.4	-1.5	-1.5	1.5	-0.5	1.1	0.4
Degree of sensitization stereotypy	0.1	0.1	0.6	-0.0	-0.0	0.0	-0.4	-0.0	0.7
Conditioned locomotion	0.8	1.0	1.9	1.0	1.0	-1.0	-0.3	-0.9	1.4
Cocaine response after cond. corrected	0.8	1.1	1.8	-1.3	-1.3	1.3	-0.2	1.2	0.3
Cocaine response after cond. not corrected	0.5	0.8	1.1	-1.1	-1.1	1.1	-0.7	0.9	0.2
Cocaine response before conditioning	0.5	0.7	0.9	1.0	1.0	-1.0	-0.7	-0.8	-0.3
Saline control response	0.4	0.6	3.0	-0.2	-0.2	0.2	0.0	0.6	1.7
Bone: connectivity density	0.6	1.0	1.4	1.2	1.2	-1.2	0.4	-1.1	-0.5
Bone: cortical apparent density	1.0	1.6	7.8	-0.1	-0.1	0.1	2.8	-0.1	-1.4
Bone: cortical area	0.4	0.6	1.5	-0.7	-0.7	0.7	0.4	0.8	-1.2
Bone: cortical porosity	1.0	1.1	1.9	1.2	1.2	-1.2	-0.9	-1.4	0.2
Bone: cortical porosity	2.0	2.2	4.1	1.7	1.7	-1.7	-0.5	-2.0	-0.6
Bone: cortical thickness	0.4	0.7	1.0	1.0	1.0	-1.0	0.4	-0.7	-0.7
Bone: cortical thickness	0.2	0.3	1.6	0.0	0.0	-0.0	-1.3	0.1	0.2
Bone: cortical tissue density	1.0	1.6	7.7	-0.1	-0.1	0.1	2.8	-0.1	-1.3
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.9	0.9	-0.9	0.6	-1.0	0.3
Condit. Reinf. active-inactive response ratio	2.8	3.0	4.6	2.1	2.1	-2.1	-0.3	-2.1	0.0
Condit. Reinf. active responses	0.0	0.1	0.2	-0.1	-0.1	0.1	0.4	-0.1	0.4
Condit. Reinf. inactive responses	1.5	1.9	3.0	-1.7	-1.7	1.7	0.2	1.5	0.4
Incentive salience index mean	0.1	0.2	0.7	0.2	0.2	-0.2	0.3	-0.4	0.8
Condit. Reinf. lever presses	0.2	0.2	1.3	0.1	0.1	-0.1	-0.3	-0.2	1.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2	-0.0	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.5	-0.5	0.5	0.5	0.1	-0.4
Condit. Reinf. active responses	0.1	0.1	0.7	-0.1	-0.1	0.1	-0.3	-0.0	0.9
Condit. Reinf. inactive responses	0.4	0.6	2.6	0.1	0.1	-0.1	-0.9	0.3	1.6
Condit. Reinf. lever presses	0.5	0.8	1.5	-0.7	-0.7	0.7	-1.2	0.5	1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	1.9	-0.2	-0.2	0.2	-0.7	0.1	1.4
Conditioned reinforcement - actives	0.0	0.1	0.3	0.0	0.0	-0.0	-0.6	-0.5	0.4
Conditioned reinforcement - inactives	0.5	1.4	1.9	-1.4	-1.4	1.4	-0.3	1.2	1.0
Conditioned locomotion	0.1	0.2	1.1	0.0	0.0	-0.0	0.1	-0.3	-1.1
Patch foraging indifference point 0 sec	0.1	0.3	0.5	-0.7	-0.7	0.7	0.1	0.5	0.7
Patch foraging indifference point AUC	1.7	4.1	5.6	-2.4	-2.4	2.4	0.9	2.2	1.4
Delay disc. indifference point, 0s delay	0.4	0.4	1.3	-0.0	-0.0	0.0	0.9	-0.6	-1.2
Delay disc. indifference point, 16s delay	0.7	1.0	2.3	0.5	0.5	-0.5	1.5	-0.7	-1.5
Delay disc. indifference point, 2s delay	3.2	3.5	5.5	-2.3	-2.3	2.3	0.3	2.1	0.6
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	0.1	0.1	-0.1	0.1	-0.4	-0.2
Delay disc. indifference point, 4s delay	1.2	1.3	2.4	-1.0	-1.0	1.0	1.3	0.9	-1.5
Delay disc. indifference point, 8s delay	0.8	1.3	2.1	1.1	1.1	-1.1	0.9	-1.4	-1.3
Indifference point function ln k	0.7	2.1	2.9	1.7	1.7	-1.7	-1.0	-1.6	-0.3
Indifference point function log k	0.7	2.1	2.9	1.7	1.7	-1.7	-1.0	-1.6	-0.3
Patch foraging total patch changes 0 sec	0.1	0.4	0.7	-0.7	-0.7	0.7	0.2	0.6	0.8
Patch foraging total patch changes 12 sec	0.5	0.7	1.8	-0.7	-0.7	0.7	1.3	0.7	0.6
Patch foraging total patch changes 18 sec	0.2	0.5	0.6	-0.7	-0.7	0.7	0.5	0.7	0.8
Patch foraging total patch changes 24 sec	0.2	0.8	1.1	-1.1	-1.1	1.1	0.1	0.9	0.9
Patch foraging total patch changes 6 sec	1.7	2.9	4.4	-2.0	-2.0	2.0	0.8	2.1	0.3
Patch foraging time to switch 0 sec	1.1	4.3	5.6	2.4	2.4	-2.4	0.7	-2.4	-1.7
Patch foraging water rate 0 sec	0.6	2.2	3.5	-1.7	-1.7	1.7	-0.1	1.9	1.0
Patch foraging water rate 12 sec	0.2	0.6	1.5	-0.4	-0.4	0.4	-1.2	0.7	1.2
Patch foraging water rate 18 sec	0.6	1.3	1.7	-1.2	-1.2	1.2	-0.8	1.2	1.3
Patch foraging water rate 24 sec	1.4	2.1	3.5	-1.1	-1.1	1.1	-1.9	1.3	1.8
Patch foraging water rate 6 sec	0.7	1.0	1.9	-1.2	-1.2	1.2	-0.2	1.4	0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.8	-0.6	-0.6	0.6	-0.3	0.4	0.9
Distance traveled before self-admin	0.2	0.5	0.9	1.0	1.0	-1.0	-0.1	-0.6	0.2
Distance traveled after self-admin	1.9	3.4	6.3	-1.6	-1.6	1.6	-1.7	1.9	2.5
Extensor digitorum longus weight	6.3	25.0	37.4	6.0	6.0	-6.0	-0.7	-6.1	-1.5
Bone: elastic displacement	0.7	0.8	3.1	0.6	0.6	-0.6	-1.8	-0.8	0.7
Bone: elastic work	0.6	0.8	3.6	0.5	0.5	-0.5	-1.9	-0.6	-0.0
Bone: endosteal estimation	1.2	3.0	4.6	-2.2	-2.2	2.2	-0.9	1.8	0.0
Bone: endosteal perimeter	0.5	1.3	1.5	-1.2	-1.2	1.2	-1.0	1.0	-1.2
Epididymis fat weight	0.5	2.4	10.7	0.1	0.1	-0.1	3.3	-0.2	-1.8
Delta time in closed arm before/after self-admin	0.7	0.7	1.1	0.9	0.9	-0.9	0.3	-1.0	-0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.7	-0.6	-0.6	0.6	0.8	0.5	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.4	1.9	0.3	0.3	-0.3	-0.6	0.2	1.4
Delay discount exponential model param	0.3	0.4	0.8	0.6	0.6	-0.6	-0.9	-0.3	0.8
Extinction: sum of active levers before priming	0.2	0.2	0.6	0.4	0.4	-0.4	-0.8	-0.4	-0.4
Active lever presses in extinction session 6	0.5	0.5	0.8	-0.8	-0.8	0.8	0.1	0.9	-0.4
Bone: final force	0.1	0.2	0.8	-0.1	-0.1	0.1	0.2	0.2	-0.9
Bone: final moment	0.2	0.3	1.3	-0.1	-0.1	0.1	0.2	0.3	-1.2
Food consumed during 24 hour testing period	1.0	2.1	3.1	-1.3	-1.3	1.3	-1.2	1.6	1.8
Glucose	1.3	2.0	3.5	-1.6	-1.6	1.6	-0.0	1.9	0.7
Heart weight	0.9	1.4	2.3	1.2	1.2	-1.2	0.4	-1.5	-1.2
Delay discount hyperbolic model param	0.5	0.6	0.8	0.9	0.9	-0.9	-0.8	-0.6	0.6
Intermittent access intake day 1-15 change	0.1	0.4	1.8	0.3	0.3	-0.3	-0.5	-0.4	1.4
Intermittent access intake escalation	0.1	0.5	1.3	0.7	0.7	-0.7	-0.3	-0.7	1.2
Intermittent access intake escalation 2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.1	0.5	0.7
Intermitt. access day 1 inactive lever presses	0.2	2.7	5.9	-1.6	-1.6	1.6	-0.4	1.5	2.4
Intermitt. access day 15 inactive lever presses	0.5	2.5	3.6	-1.9	-1.9	1.9	0.0	1.9	0.9
Intermitt. access escalation Index	0.2	0.7	1.3	1.1	1.1	-1.1	0.2	-0.6	-0.4
Intermittent access day 1 total infusions	0.1	0.3	0.6	-0.5	-0.5	0.5	-0.8	0.2	-0.5
Intermittent access day 15 total infusions	0.2	0.4	1.4	-0.4	-0.4	0.4	-1.2	0.2	0.8
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.2	-0.9	-0.9	0.9	-1.1	1.0	1.1
Intermittent access total infusions	0.2	0.2	0.9	-0.4	-0.4	0.4	-0.9	0.2	0.0
Intermittent access day 1 locomotion	0.2	0.4	0.6	-0.8	-0.8	0.8	-0.4	0.5	0.3
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	0.1	-0.0
Intermittent access total locomotion	0.1	0.1	0.2	-0.1	-0.1	0.1	0.4	-0.1	-0.5
Intermittent access standard deviation	0.2	1.2	1.7	-1.3	-1.3	1.3	-0.9	0.9	0.8
Left kidney weight	0.0	0.3	1.7	0.2	0.2	-0.2	0.1	-0.2	-1.3
Right kidney weight	0.2	1.1	3.2	-0.5	-0.5	0.5	1.5	0.6	-1.8
Cocaine induced anxiety	0.3	0.9	1.7	0.9	0.9	-0.9	1.0	-0.8	-1.3
Post-drug Anxiety	0.1	0.1	0.3	-0.2	-0.2	0.2	0.5	0.1	-0.5
Baseline Anxiety	1.8	3.0	6.3	-1.4	-1.4	1.4	-2.5	1.3	2.0
Tail length	0.1	0.7	1.1	-0.9	-0.9	0.9	-0.2	0.9	1.0
Length with tail	0.4	1.6	2.3	-1.5	-1.5	1.5	-0.7	1.3	0.8
Length without tail	0.2	1.3	1.8	-1.3	-1.3	1.3	-0.9	1.1	0.3
Times rat made contact with spout	0.6	0.6	1.0	-1.0	-1.0	1.0	0.5	0.9	-0.0
Lifetime Intake	0.1	0.1	0.6	-0.2	-0.2	0.2	-0.8	-0.0	-0.1
Liver weight, left	1.2	2.0	2.9	-1.3	-1.3	1.3	1.7	1.3	-1.7
Liver weight, right	0.9	1.6	2.4	-1.6	-1.6	1.6	0.7	1.4	-0.1
Locomotor activity	0.2	0.4	1.8	-0.2	-0.2	0.2	-1.4	0.3	-0.4
Locomotor testing distance	0.5	1.2	5.0	0.7	0.7	-0.7	-2.2	-0.6	-0.0
Locomotor testing rearing	0.3	1.0	4.0	0.6	0.6	-0.6	-2.0	-0.6	0.4
Locomotion in novel chamber	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2	-0.1	-0.3
Locomotion in novel chamber post-restriction	0.3	0.9	1.2	-1.1	-1.1	1.1	1.1	0.9	-0.1
Fecal boli incidents, locomotor time 1	0.5	1.4	2.2	1.5	1.5	-1.5	-0.7	-1.2	0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.3	-0.3	0.3	-0.1	0.2	-0.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	0.7	0.7	-0.7	-0.4	-0.5	-0.5
Bouts of movement, locomotor time 1	0.5	0.6	1.0	0.8	0.8	-0.8	0.2	-1.0	-0.9
Total resting periods, locomotor time 1	0.3	0.4	1.0	0.5	0.5	-0.5	0.3	-0.6	-1.0
Rest time, locomotor task time 1	0.5	0.8	2.5	-0.4	-0.4	0.4	-1.6	0.6	1.3
Distance moved, locomotor task time 1	0.0	0.1	0.3	0.3	0.3	-0.3	0.3	-0.0	-0.5
Vertical activity count, locomotor time 1	0.2	1.5	5.0	-0.4	-0.4	0.4	2.2	0.7	-1.7
Time >=10cm from walls, locomotor time 2	0.1	0.3	1.4	0.4	0.4	-0.4	-1.2	-0.5	0.3
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.4	-0.4	0.4	-0.2	0.3	-0.0
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.0	0.2	-0.1
Rest time, locomotor task time 2	0.6	1.0	3.1	-0.0	-0.0	0.0	-1.8	0.5	1.7
Distance moved, locomotor task time 2	0.9	1.2	1.5	1.2	1.2	-1.2	0.9	-1.1	-0.9
Vertical activity count, locomotor time 2	0.4	1.0	4.3	0.1	0.1	-0.1	2.1	0.0	-1.2
Light reinforcement 1	0.1	0.3	0.4	-0.6	-0.6	0.6	0.4	0.4	0.4
Light reinforcement 2	0.1	0.2	0.6	0.2	0.2	-0.2	0.2	-0.8	-0.7
Bone: marrow area	1.2	3.0	4.5	-2.1	-2.1	2.1	-1.0	1.8	0.1
Bone: maximum diameter	0.6	1.2	4.3	-0.8	-0.8	0.8	0.8	0.6	-2.1
Bone: maximum force	0.1	0.2	0.5	-0.4	-0.4	0.4	-0.3	0.5	-0.7
Bone: maximum moment	0.2	0.4	1.1	-0.5	-0.5	0.5	-0.3	0.6	-1.0
Mean time between licks in bursts	0.7	4.1	5.3	2.2	2.2	-2.2	0.4	-2.3	-2.1
Mean num. licks in bursts	0.5	1.4	1.9	-1.4	-1.4	1.4	0.8	1.1	1.0
Cd content in liver	2.2	2.4	4.1	1.8	1.8	-1.8	-0.3	-2.0	-1.0
Co content in liver	0.2	0.2	0.4	0.5	0.5	-0.5	0.0	-0.5	-0.6
Cu content in liver	0.1	0.1	0.1	0.3	0.3	-0.3	0.2	-0.2	0.2
Fe content in liver	1.2	1.4	2.5	1.2	1.2	-1.2	1.6	-1.1	-1.0
K content in liver	0.5	0.5	1.9	-0.1	-0.1	0.1	1.4	0.6	0.8
Mg content in liver	0.3	0.4	1.9	-0.2	-0.2	0.2	1.4	0.4	-0.1
Mn content in liver	0.4	0.4	1.3	0.5	0.5	-0.5	-0.3	-0.4	1.1
Na content in liver	0.5	0.6	1.3	-0.6	-0.6	0.6	1.2	1.0	-0.3
Rb content in liver	1.1	1.3	1.5	1.2	1.2	-1.2	0.8	-1.2	-0.9
Se content in liver	0.4	0.5	2.5	-0.2	-0.2	0.2	0.5	0.3	1.6
Sr content in liver	1.1	0.9	3.0	0.7	0.7	-0.7	-1.7	-0.9	-0.1
Zn content in liver	0.2	0.2	0.7	0.3	0.3	-0.3	0.0	-0.3	0.9
Bone: minimum diameter	2.9	5.6	8.6	-2.9	-2.9	2.9	0.1	2.8	-0.5
Time in familiar zone, hab. session 1	0.2	0.3	1.1	-0.0	-0.0	0.0	-1.0	0.3	0.7
Time in novel zone, hab. session 1	1.0	1.1	3.9	0.3	0.3	-0.3	2.0	-0.6	-1.4
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.4	-0.4	0.4	-0.2	-0.0	0.3
Total locomotion distance, hab. session 1	1.0	1.5	1.8	-1.3	-1.3	1.3	-1.3	1.0	1.0
Locomotion velocity, hab. session 1	1.1	1.6	2.9	-1.2	-1.2	1.2	-1.7	0.9	1.2
Time in familiar zone, hab. session 2	0.2	0.3	0.5	0.7	0.7	-0.7	-0.2	-0.4	-0.3
Time in novel zone, hab. session 2	0.5	0.6	2.4	-0.3	-0.3	0.3	1.5	0.1	-1.0
Total zone transitions, hab. session 2	0.4	0.5	1.4	0.0	0.0	-0.0	-1.1	-0.2	-1.2
Total locomotion distance, hab. session 2	0.5	0.6	1.9	-0.7	-0.7	0.7	-1.4	0.5	-0.4
Locomotion velocity, hab. session 2	0.5	0.7	2.4	-0.7	-0.7	0.7	-1.5	0.5	-0.2
Novel to familiar place preference ratio	0.4	0.6	2.5	-0.5	-0.5	0.5	1.6	0.4	-0.3
Novelty place preference	0.6	0.7	3.5	-0.3	-0.3	0.3	1.9	0.2	-0.7
Time in novel zone, NPP test	0.8	0.9	4.4	-0.5	-0.5	0.5	2.1	0.4	-0.6
Total zone transitions, NPP test	0.3	0.4	2.3	-0.0	-0.0	0.0	0.2	0.1	-1.5
Total locomotion distance, NPP test	0.2	0.3	1.5	-0.1	-0.1	0.1	-1.2	0.1	-0.5
Locomotion velocity, NPP test	0.3	0.4	1.9	0.2	0.2	-0.2	-1.4	-0.1	-0.5
Intraocular pressure	0.7	1.1	5.8	0.1	0.1	-0.1	0.6	-0.5	-2.4
Delta distance traveled before/after self-admin	3.2	3.5	4.0	-2.0	-2.0	2.0	-1.3	1.9	1.9
Delta ambulatory time before/after self-admin	0.9	1.5	1.7	-1.3	-1.3	1.3	-1.0	1.1	1.2
Parametrial fat weight	1.4	3.4	4.4	-2.0	-2.0	2.0	1.6	2.1	-0.8
Pavlov. Cond. lever latency	0.7	0.8	2.6	0.6	0.6	-0.6	-1.0	-0.7	-1.6
Pavlov. Cond. magazine entry latency	0.6	0.8	4.3	0.2	0.2	-0.2	-0.7	-0.1	2.1
Pavlov. Cond. change in total contacts	0.4	0.4	2.0	0.2	0.2	-0.2	0.6	0.0	1.4
Pavlov. Cond. index score	0.7	0.9	4.8	-0.1	-0.1	0.1	0.5	0.2	2.2
Pavlov. Cond. latency score	0.7	0.8	4.5	-0.3	-0.3	0.3	0.4	0.4	2.1
Pavlov. Cond. lever contacts	0.6	0.7	2.8	-0.5	-0.5	0.5	0.7	0.6	1.7
Pavlov. Cond. magazine entry number	0.4	0.5	2.7	-0.1	-0.1	0.1	0.1	0.0	-1.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.2	0.0	0.0	-0.0	1.5	0.2	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	5.0	-0.2	-0.2	0.2	0.5	0.4	2.2
Pavlov. Cond. response bias	0.5	0.6	3.2	-0.2	-0.2	0.2	0.4	0.4	1.8
Pavlov. Cond. lever latency	0.6	0.9	3.1	-0.6	-0.6	0.6	1.7	0.8	-0.8
Pavlov. Cond. magazine entry latency	1.0	1.4	2.3	1.2	1.2	-1.2	-1.5	-1.4	-0.5
Pavlov. Cond. change in total contacts	0.4	1.1	2.9	0.9	0.9	-0.9	-1.7	-0.9	0.5
Pavlov. Cond. index score	0.9	1.5	4.1	1.0	1.0	-1.0	-2.0	-1.1	0.4
Pavlov. Cond. latency score	1.3	2.0	4.9	1.3	1.3	-1.3	-2.2	-1.4	0.4
Pavlov. Cond. lever contacts	0.3	0.5	2.3	0.2	0.2	-0.2	-1.5	-0.4	0.7
Pavlov. Cond. magazine entry number	2.0	2.5	3.6	-1.6	-1.6	1.6	1.9	1.8	0.5
Pavlov. Cond. intertrial magazine entries	1.0	2.2	2.7	-1.6	-1.6	1.6	1.6	1.4	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.4	3.6	1.0	1.0	-1.0	-1.9	-1.1	0.5
Pavlov. Cond. response bias	0.6	0.8	2.8	0.7	0.7	-0.7	-1.7	-0.9	0.4
Time in closed arm before self-admin	0.3	0.5	1.1	-0.7	-0.7	0.7	-0.2	0.6	1.0
Time in closed arm after self-admin	0.5	0.6	1.8	0.3	0.3	-0.3	-1.0	-0.6	1.3
Time in open arm before self-admin	0.8	0.9	2.4	1.0	1.0	-1.0	-1.5	-0.7	0.0
Time in open arm after self-admin	1.0	1.1	1.5	-0.9	-0.9	0.9	1.2	1.1	-1.1
Bone: periosteal estimation	0.7	1.8	2.6	-1.6	-1.6	1.6	-0.3	1.4	-0.8
Bone: periosteal perimeter	0.6	1.2	2.2	-1.2	-1.2	1.2	-0.6	0.9	-1.5
Bone: post-yield work	0.2	0.3	1.4	-0.1	-0.1	0.1	0.6	0.3	-1.2
Progressive ratio test 1 active lever presses	0.3	0.5	0.9	0.7	0.7	-0.7	-0.6	-0.9	-0.4
Progressive ratio test 1 breakpoint	0.2	0.4	0.6	0.6	0.6	-0.6	-0.7	-0.8	-0.2
Progressive ratio test 1 inactive lever presses	1.0	2.7	4.1	-1.8	-1.8	1.8	-0.6	1.6	2.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	-0.2	-0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.2	-0.0	-0.0	0.0	-0.4	-0.3	-0.2
Progressive ratio test 2 inactive lever presses	0.3	1.1	1.6	-1.1	-1.1	1.1	-0.5	0.9	1.3
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.2	-0.2	0.2	0.1	-0.0	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.0	-0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.6	0.2	0.2	-0.2	-0.5	0.3	0.8
Progressive ratio	0.1	0.4	1.4	-0.1	-0.1	0.1	-1.0	0.1	1.2
Food seeking constrained by brief footshock	0.3	0.4	0.9	0.6	0.6	-0.6	0.0	-0.9	0.2
Seeking ratio, punishment vs. effort	0.3	0.6	2.1	-0.2	-0.2	0.2	1.4	0.1	-1.1
Retroperitoneal fat weight	0.5	2.4	5.7	-1.0	-1.0	1.0	2.4	1.0	-2.1
Reaction time number correct	0.0	0.1	0.2	0.3	0.3	-0.3	-0.4	-0.0	-0.5
Reaction time mean minus median	0.1	0.7	2.0	0.6	0.6	-0.6	1.1	-0.4	-1.4
Reaction time mean minus median AUC	0.2	1.1	3.8	0.5	0.5	-0.5	1.9	-0.1	-1.5
Reaction time num false alarms	0.2	0.4	2.1	-0.2	-0.2	0.2	1.4	0.1	-0.2
Reaction time num false alarms AUC	0.2	0.4	2.2	0.2	0.2	-0.2	1.5	-0.2	-0.4
Reaction time trials correct on left	0.0	0.1	0.2	0.3	0.3	-0.3	-0.4	-0.0	-0.5
Reaction time trials on left	0.0	0.1	0.3	0.3	0.3	-0.3	-0.4	-0.1	-0.5
Reaction time mean	0.3	0.6	0.7	0.7	0.7	-0.7	0.9	-0.7	-0.7
Reaction time mean AUC	0.3	0.8	1.2	0.9	0.9	-0.9	1.1	-0.8	-0.6
Median of all reaction times	0.3	0.5	0.6	0.7	0.7	-0.7	0.7	-0.8	-0.3
Reaction time omissions	0.7	1.2	1.7	1.3	1.3	-1.3	-0.2	-1.3	-0.7
Reaction time false alarm rate	0.3	0.4	2.2	-0.0	-0.0	0.0	1.5	-0.2	-0.1
Reaction time premature initiation rate	0.4	0.7	2.9	-0.5	-0.5	0.5	0.5	0.5	1.7
Reaction time premature initiations	0.1	0.4	1.4	-0.4	-0.4	0.4	0.6	0.6	1.2
Std. dev. reaction times	0.2	0.6	1.4	0.7	0.7	-0.7	0.8	-0.5	-1.2
Reaction time trials completed	0.0	0.1	0.3	0.3	0.3	-0.3	-0.4	-0.1	-0.5
Reaction time trials AUC	0.0	0.2	0.6	0.3	0.3	-0.3	-0.2	-0.1	-0.8
Run reversals in cocaine runway, females	0.7	0.8	1.2	-1.0	-1.0	1.0	-0.1	1.1	-1.0
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	-0.3	0.2
Latency to leave start box in cocaine runway	2.4	3.3	5.3	-2.1	-2.1	2.1	0.5	2.3	-1.0
Latency to leave start box in cocaine runway, F	5.1	6.3	9.2	-3.0	-3.0	3.0	0.7	3.0	-1.0
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.3	-0.2
Std. dev. time between licks in bursts	1.0	1.8	3.0	1.6	1.6	-1.6	-0.6	-1.7	0.3
Total sessions with >9 infusions	1.1	1.4	1.9	1.3	1.3	-1.3	0.1	-1.4	-1.0
Short access day 1 total inactive lever presses	1.0	2.0	2.5	-1.4	-1.4	1.4	-1.4	1.6	1.3
Short access day 10 total inactive lever presses	0.2	1.5	1.8	-1.3	-1.3	1.3	-0.9	1.3	1.2
Short access day 1 total infusions	0.1	0.1	0.4	-0.4	-0.4	0.4	0.1	0.6	-0.3
Short access day 10 total infusions	0.2	0.2	0.6	0.4	0.4	-0.4	-0.8	-0.5	-0.4
Short access total infusions	0.2	0.3	0.6	0.5	0.5	-0.5	-0.4	-0.6	-0.8
Short access day 1 locomotion	0.4	0.6	1.5	0.8	0.8	-0.8	-0.3	-0.3	-1.2
Short access day 10 total locomotion	0.0	0.0	0.2	0.0	0.0	-0.0	-0.2	-0.2	0.4
Short access total locomotion	0.3	0.5	1.2	0.7	0.7	-0.7	0.1	-0.6	-1.1
One hour access (0.3 mA shock)	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.7	0.6	0.2
Compulsive drug intake	0.4	0.5	1.3	-0.7	-0.7	0.7	-0.2	0.8	1.1
One hour access (shock baseline)	0.0	0.1	0.6	-0.1	-0.1	0.1	0.1	0.1	-0.8
Social response proportion	1.9	2.4	3.3	-1.8	-1.8	1.8	1.2	1.8	0.6
Social responses	1.4	1.9	2.8	-1.7	-1.7	1.7	0.6	1.5	0.7
Social time	0.6	0.9	1.2	-1.1	-1.1	1.1	0.5	0.9	0.8
Soleus weight	0.5	1.5	6.7	0.3	0.3	-0.3	-2.6	-0.8	1.1
Bone: stiffness	0.6	1.0	2.0	-1.0	-1.0	1.0	1.4	1.1	-0.5
Tibialis anterior weight	2.4	8.3	12.3	3.5	3.5	-3.5	0.5	-3.5	-0.7
Time to tail flick, vehicle, before self-admin	1.2	1.5	2.1	-1.4	-1.4	1.4	-0.7	1.5	0.5
Time to tail flick, vehicle, after self-admin	1.1	2.3	5.6	-1.1	-1.1	1.1	-2.4	0.9	1.8
Time to tail flick, test, before self-admin	0.2	0.2	0.8	0.3	0.3	-0.3	-0.6	-0.1	0.9
Time to tail flick, test, after self-admin	0.8	0.8	1.4	-1.0	-1.0	1.0	0.2	1.2	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.3	-0.1	0.4
Delta time to tail flick, test, before/after SA	0.8	1.0	1.3	-1.1	-1.1	1.1	1.0	1.1	-0.2
Tibia length	0.2	0.7	0.9	-0.9	-0.9	0.9	0.4	0.8	-1.0
Ambulatory time before self-admin	0.1	0.3	0.5	0.7	0.7	-0.7	0.0	-0.4	0.1
Ambulatory time after self-admin	1.6	2.6	3.9	-1.5	-1.5	1.5	-1.4	1.7	2.0
Bone: tissue strength	0.7	0.8	1.3	-1.1	-1.1	1.1	0.1	0.9	-0.1
Total heroin consumption	0.9	1.1	1.6	-1.1	-1.1	1.1	-1.3	1.0	0.0
Bone: trabecular number	0.1	0.2	0.7	0.2	0.2	-0.2	0.9	-0.3	-0.2
Bone: trabecular spacing	0.4	0.5	2.7	0.2	0.2	-0.2	1.6	-0.0	-0.6
Bone: trabecular thickness	0.1	0.2	0.6	-0.4	-0.4	0.4	-0.8	0.0	0.4
Bone: trabecular tissue density	0.6	1.0	2.7	0.7	0.7	-0.7	1.0	-0.9	-1.6
Water consumed over 24 hours	0.7	1.4	2.1	-1.4	-1.4	1.4	-0.4	1.3	0.2
Number of responses in last shaping day	0.4	0.5	0.8	0.9	0.9	-0.9	0.7	-0.6	0.2