Hub : Genes

Tmie

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	mRNA stability	Tmie	0.11	0.11	4.3e-05	0.06	0.07	0.05	0.07	2.2e-04	1.6e-04	1.5e-03	9.5e-05
2	PL	mRNA stability	Tmie	0.02	0.02	8.9e-03	0.01	0.01	0.01	0	2.8e-02	6.3e-02	4.9e-02	1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.0	0.0	0.1	-0.2
Area under the delay curve	2.0	2.2	2.4	-1.6	1.4
BMI with tail	0.2	0.7	0.9	0.9	-0.7
BMI without tail	1.5	3.2	3.3	1.8	-1.8
Body weight	6.4	26.9	28.6	5.3	-5.0
Weight adjusted by age	0.2	0.2	0.3	0.4	-0.5
Bone surface	0.1	0.1	0.2	-0.4	0.3
Bone volume	0.0	0.0	0.0	-0.2	0.1
Breakpoint value in progressive ratio session	0.3	0.3	0.5	0.7	-0.3
Number of licking bursts	0.1	0.1	0.2	-0.3	0.4
Context. condit. distance diff. score	0.0	0.0	0.0	-0.0	-0.0
Locomotion velocity, session 1	0.1	0.1	0.1	-0.4	0.3
Locomotion distance, session 1	0.5	0.7	0.7	0.8	-0.8
Locomotion velocity, session 2	0.4	0.4	0.4	-0.7	0.7
Locomotion distance, session 2	0.1	0.1	0.1	-0.4	0.3
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	-0.2
Locomotion distance, session 3	1.3	1.5	1.6	-1.3	1.2
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	0.3	-0.2
Stereotopy head waving duration, day 3	0.3	0.4	0.4	0.6	-0.6
Locomotion velocity, session 7	0.2	0.2	0.3	0.4	-0.6
Locomotion distance, session 7	0.7	0.9	1.0	-1.0	0.9
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.2
Stereotopy head waving duration, day 7	0.3	0.3	0.3	0.6	-0.5
Locomotion velocity, session 8	0.1	0.1	0.1	0.3	-0.3
Locomotion distance, session 8	0.1	0.1	0.1	0.2	-0.3
Degree of sensitization distance	1.6	1.6	1.6	1.3	-1.2
Degree of sensitization stereotypy	0.0	0.0	0.0	0.2	-0.2
Conditioned locomotion	2.8	3.3	3.5	-1.9	1.8
Cocaine response after cond. corrected	0.3	0.3	0.4	0.6	-0.5
Cocaine response after cond. not corrected	1.8	2.0	2.2	1.5	-1.3
Cocaine response before conditioning	0.8	1.0	1.0	1.0	-1.0
Saline control response	1.5	1.9	2.1	1.4	-1.4
Bone: connectivity density	0.2	0.2	0.3	-0.5	0.4
Bone: cortical apparent density	0.2	0.3	0.3	-0.5	0.6
Bone: cortical area	0.1	0.2	0.2	-0.5	0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.0
Bone: cortical porosity	0.1	0.1	0.1	-0.3	0.2
Bone: cortical thickness	0.1	0.1	0.1	0.4	-0.4
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.1
Bone: cortical tissue density	0.2	0.3	0.3	-0.5	0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	0.6	-0.6
Condit. Reinf. active responses	0.0	0.0	0.0	-0.0	0.0
Condit. Reinf. inactive responses	0.6	0.7	0.7	-0.8	0.8
Incentive salience index mean	0.1	0.1	0.1	-0.3	0.3
Condit. Reinf. lever presses	1.8	2.4	2.5	-1.6	1.6
Condit. Reinf. active minus inactive responses	1.9	2.4	2.7	1.6	-1.4
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.0	1.4	-1.2
Condit. Reinf. active responses	1.7	2.3	2.6	1.6	-1.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	0.2
Condit. Reinf. lever presses	2.3	3.2	3.5	1.9	-1.7
Condit. Reinf. lever reinforcers received	1.8	2.6	2.9	1.7	-1.5
Conditioned reinforcement - actives	0.4	0.4	0.6	-0.6	0.7
Conditioned reinforcement - inactives	0.9	1.0	1.0	-1.0	1.0
Conditioned locomotion	0.5	0.6	0.7	-0.7	0.8
Patch foraging indifference point 0 sec	0.9	1.5	1.5	1.2	-1.2
Patch foraging indifference point AUC	0.1	0.1	0.2	0.4	-0.2
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.1	0.2
Delay disc. indifference point, 16s delay	1.1	1.1	1.4	-1.2	0.9
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	-0.6	0.5
Delay disc. indifference point, 24s delay	0.9	0.8	1.0	-1.0	0.8
Delay disc. indifference point, 4s delay	2.1	2.2	2.3	-1.5	1.4
Delay disc. indifference point, 8s delay	2.0	2.1	2.4	-1.5	1.3
Indifference point function ln k	0.4	0.6	0.6	-0.8	0.7
Indifference point function log k	0.4	0.6	0.6	-0.8	0.7
Patch foraging total patch changes 0 sec	1.1	1.7	1.8	1.3	-1.3
Patch foraging total patch changes 12 sec	1.0	1.3	1.4	1.2	-1.1
Patch foraging total patch changes 18 sec	2.8	3.6	4.0	2.0	-1.8
Patch foraging total patch changes 24 sec	3.3	4.0	4.1	2.0	-2.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.2	0.5	-0.4
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.4	0.2
Patch foraging water rate 0 sec	0.1	0.1	0.1	0.4	-0.2
Patch foraging water rate 12 sec	0.2	0.3	0.4	0.6	-0.4
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.1	-0.0
Patch foraging water rate 24 sec	0.7	1.0	1.3	1.2	-0.8
Patch foraging water rate 6 sec	0.2	0.3	0.3	0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	2.4	2.7	3.1	-1.6	1.7
Distance traveled before self-admin	0.0	0.0	0.1	-0.3	-0.1
Distance traveled after self-admin	0.4	0.4	0.6	-0.8	0.5
Extensor digitorum longus weight	0.2	0.7	0.7	-0.8	0.9
Bone: elastic displacement	0.1	0.1	0.1	0.3	-0.2
Bone: elastic work	0.4	0.5	0.5	0.7	-0.7
Bone: endosteal estimation	0.1	0.2	0.2	0.4	-0.5
Bone: endosteal perimeter	1.4	2.9	3.0	-1.7	1.7
Epididymis fat weight	0.4	1.0	1.1	1.0	-0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	-0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0
Delay discount exponential model param	2.4	2.5	2.8	1.7	-1.5
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.3	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.3	0.3	-0.5
Bone: final force	0.8	1.3	1.3	1.1	-1.1
Bone: final moment	1.0	1.7	1.7	1.3	-1.3
Food consumed during 24 hour testing period	1.3	1.5	1.5	1.2	-1.2
Glucose	0.3	0.4	0.5	0.7	-0.6
Heart weight	2.3	3.3	3.7	1.9	-1.7
Delay discount hyperbolic model param	2.3	2.5	2.8	1.7	-1.5
Intermittent access intake day 1-15 change	0.6	0.6	0.7	-0.8	0.8
Intermittent access intake escalation	0.5	0.5	0.5	-0.7	0.7
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.0	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.2	0.0
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	-0.9	0.8
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	-0.0
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	0.2
Intermittent access day 15 total infusions	0.4	0.4	0.4	-0.7	0.7
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	-0.5	0.5
Intermittent access total infusions	0.6	0.7	0.7	-0.8	0.8
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 15 total locomotion	0.7	0.8	0.8	-0.9	0.8
Intermittent access total locomotion	1.4	1.6	1.6	-1.3	1.2
Intermittent access standard deviation	0.2	0.2	0.2	0.4	-0.4
Left kidney weight	0.6	1.6	2.0	1.4	-1.1
Right kidney weight	0.1	0.3	0.3	0.6	-0.4
Cocaine induced anxiety	0.6	0.7	0.7	-0.8	0.8
Post-drug Anxiety	0.2	0.2	0.2	-0.5	0.4
Baseline Anxiety	0.1	0.1	0.1	-0.3	0.3
Tail length	7.4	22.4	22.4	4.7	-4.7
Length with tail	9.9	36.3	37.4	6.1	-5.9
Length without tail	6.4	14.0	15.1	3.9	-3.6
Times rat made contact with spout	0.4	0.5	0.5	0.7	-0.7
Lifetime Intake	0.4	0.5	0.5	-0.7	0.7
Liver weight, left	0.1	0.2	0.2	0.4	-0.5
Liver weight, right	1.4	2.3	2.4	1.5	-1.6
Locomotor activity	5.4	8.6	9.5	3.1	-2.8
Locomotor testing distance	5.3	8.9	9.5	3.1	-2.9
Locomotor testing rearing	0.2	0.4	0.4	0.6	-0.6
Locomotion in novel chamber	0.2	0.3	0.4	-0.3	0.6
Locomotion in novel chamber post-restriction	0.8	0.9	1.1	1.1	-0.8
Fecal boli incidents, locomotor time 1	0.4	0.5	0.6	0.7	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.3	-0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.2	-0.1
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.2	-0.1
Rest time, locomotor task time 1	0.5	0.6	0.7	-0.6	0.9
Distance moved, locomotor task time 1	1.7	1.8	1.9	1.3	-1.4
Vertical activity count, locomotor time 1	0.8	0.9	0.9	0.9	-1.0
Time >=10cm from walls, locomotor time 2	1.6	1.7	1.8	1.3	-1.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	-0.0
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.2	0.2
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	0.2
Distance moved, locomotor task time 2	0.9	1.1	1.2	1.0	-1.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	-0.3
Light reinforcement 1	0.7	1.3	1.4	1.2	-1.1
Light reinforcement 2	0.1	0.2	0.2	-0.4	0.4
Bone: marrow area	0.1	0.2	0.2	0.4	-0.5
Bone: maximum diameter	0.5	0.9	1.0	-1.0	1.0
Bone: maximum force	0.7	1.2	1.2	1.1	-1.1
Bone: maximum moment	0.8	1.3	1.4	1.2	-1.2
Mean time between licks in bursts	1.3	1.9	1.9	-1.4	1.4
Mean num. licks in bursts	0.5	0.6	0.7	0.7	-0.8
Cd content in liver	2.7	3.0	3.2	1.8	-1.7
Co content in liver	0.0	0.0	0.0	-0.1	-0.1
Cu content in liver	4.3	5.2	5.6	2.4	-2.2
Fe content in liver	2.2	2.6	2.8	1.7	-1.5
K content in liver	0.7	0.7	0.7	0.9	-0.8
Mg content in liver	0.0	0.0	0.0	-0.1	0.1
Mn content in liver	0.4	0.5	0.5	0.6	-0.7
Na content in liver	0.5	0.5	0.6	0.7	-0.7
Rb content in liver	1.6	2.0	2.0	1.4	-1.4
Se content in liver	0.0	0.1	0.1	0.3	-0.2
Sr content in liver	0.0	0.0	0.0	-0.1	0.1
Zn content in liver	4.2	4.6	5.0	2.2	-2.1
Bone: minimum diameter	0.4	0.8	0.9	-0.9	0.8
Time in familiar zone, hab. session 1	1.2	1.1	1.2	-1.1	1.0
Time in novel zone, hab. session 1	0.6	0.6	0.6	0.7	-0.8
Total zone transitions, hab. session 1	0.3	0.5	0.5	0.6	-0.7
Total locomotion distance, hab. session 1	0.2	0.2	0.3	0.5	-0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.3	0.5	-0.5
Time in familiar zone, hab. session 2	0.5	0.6	0.6	-0.7	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	-0.2
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.0	-0.0
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.5	-0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.4	-0.3
Novel to familiar place preference ratio	0.7	0.7	0.8	0.8	-0.9
Novelty place preference	0.7	0.8	0.8	0.8	-0.9
Time in novel zone, NPP test	1.0	1.1	1.1	1.0	-1.0
Total zone transitions, NPP test	1.5	2.2	2.2	1.5	-1.5
Total locomotion distance, NPP test	0.8	1.1	1.2	1.1	-1.0
Locomotion velocity, NPP test	0.8	1.2	1.3	1.1	-1.0
Intraocular pressure	1.4	1.9	2.0	1.4	-1.3
Delta distance traveled before/after self-admin	0.2	0.3	0.3	-0.5	0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.2	0.5	-0.5
Parametrial fat weight	1.1	2.1	2.3	1.5	-1.4
Pavlov. Cond. lever latency	6.0	7.6	7.7	2.8	-2.8
Pavlov. Cond. magazine entry latency	7.3	9.4	9.6	-3.1	3.0
Pavlov. Cond. change in total contacts	1.8	2.0	2.0	-1.4	1.4
Pavlov. Cond. index score	7.3	9.3	9.3	-3.0	3.0
Pavlov. Cond. latency score	7.2	9.2	9.2	-3.0	3.0
Pavlov. Cond. lever contacts	3.7	4.3	4.4	-2.1	2.1
Pavlov. Cond. magazine entry number	8.3	10.3	10.4	3.2	-3.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.6	0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	6.5	8.1	8.1	-2.8	2.9
Pavlov. Cond. response bias	7.9	9.6	9.6	-3.1	3.1
Pavlov. Cond. lever latency	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	-0.5	0.5
Pavlov. Cond. change in total contacts	2.1	3.0	3.1	1.8	-1.7
Pavlov. Cond. index score	0.0	0.0	0.0	0.2	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. lever contacts	0.8	1.1	1.2	1.1	-1.0
Pavlov. Cond. magazine entry number	0.5	0.7	0.7	0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	0.1	-0.1
Time in closed arm before self-admin	1.3	1.5	1.5	1.2	-1.2
Time in closed arm after self-admin	0.1	0.1	0.1	0.4	-0.1
Time in open arm before self-admin	0.9	1.0	1.1	-1.1	0.9
Time in open arm after self-admin	0.4	0.4	0.7	-0.8	0.4
Bone: periosteal estimation	0.0	0.0	0.0	0.0	-0.1
Bone: periosteal perimeter	1.4	2.3	2.4	-1.6	1.5
Bone: post-yield work	0.0	0.0	0.0	0.1	-0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.2	0.2
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.5	-0.5	0.7
Progressive ratio test 2 active lever presses	1.1	1.2	1.2	-1.1	1.1
Progressive ratio test 2 breakpoint	0.9	1.0	1.1	-1.0	1.0
Progressive ratio test 2 inactive lever presses	2.4	2.8	2.9	-1.7	1.6
Incentive Sensitization - Responses	1.9	1.9	1.9	-1.4	1.4
Incentive Sensitization - Breakpoint	1.9	1.9	1.9	-1.4	1.4
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.6	0.6	-0.7
Progressive ratio	3.5	4.0	4.2	2.0	-2.0
Food seeking constrained by brief footshock	1.0	1.3	1.3	-1.1	1.1
Seeking ratio, punishment vs. effort	6.2	7.5	7.6	-2.8	2.7
Retroperitoneal fat weight	0.6	2.0	2.1	1.4	-1.4
Reaction time number correct	0.4	0.6	0.6	-0.8	0.8
Reaction time mean minus median	0.0	0.1	0.1	0.3	-0.1
Reaction time mean minus median AUC	0.2	0.3	0.4	0.7	-0.4
Reaction time num false alarms	0.3	0.4	0.4	-0.7	0.6
Reaction time num false alarms AUC	0.1	0.1	0.1	-0.3	0.2
Reaction time trials correct on left	0.4	0.6	0.6	-0.8	0.8
Reaction time trials on left	0.4	0.6	0.7	-0.8	0.8
Reaction time mean	0.0	0.0	0.0	0.2	-0.1
Reaction time mean AUC	0.0	0.0	0.0	0.1	-0.0
Median of all reaction times	0.0	0.0	0.0	0.1	-0.2
Reaction time omissions	0.1	0.1	0.2	-0.3	0.4
Reaction time false alarm rate	0.0	0.0	0.0	-0.2	0.1
Reaction time premature initiation rate	2.2	3.0	3.5	1.9	-1.6
Reaction time premature initiations	1.0	1.3	1.7	1.3	-1.0
Std. dev. reaction times	0.1	0.1	0.2	0.5	-0.2
Reaction time trials completed	0.4	0.6	0.7	-0.8	0.8
Reaction time trials AUC	0.5	0.8	0.8	-0.9	0.9
Run reversals in cocaine runway, females	1.8	1.8	2.1	-1.5	1.2
Run reversals in cocaine runway, males	0.6	0.6	0.6	0.8	-0.8
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.7	-0.8
Latency to leave start box in cocaine runway, F	1.3	1.4	1.5	1.2	-1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	0.2
Std. dev. time between licks in bursts	4.4	5.3	5.3	-2.3	2.3
Total sessions with >9 infusions	0.1	0.1	0.1	0.0	0.3
Short access day 1 total inactive lever presses	3.6	4.0	4.1	-2.0	2.0
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.0	-0.0
Short access day 1 total infusions	0.7	0.8	1.0	-0.8	1.0
Short access day 10 total infusions	0.1	0.1	0.1	-0.3	0.3
Short access total infusions	0.5	0.6	0.6	-0.7	0.8
Short access day 1 locomotion	0.0	0.0	0.1	-0.2	0.3
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	-0.1
Short access total locomotion	0.0	0.0	0.0	-0.1	0.2
One hour access (0.3 mA shock)	0.2	0.2	0.2	-0.5	0.5
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.0
One hour access (shock baseline)	0.1	0.2	0.2	-0.4	0.4
Social response proportion	0.5	0.6	0.6	0.8	-0.8
Social responses	0.3	0.4	0.4	0.6	-0.6
Social time	0.4	0.6	0.8	-0.9	0.6
Soleus weight	3.8	11.0	11.2	3.4	-3.3
Bone: stiffness	0.2	0.3	0.3	0.5	-0.5
Tibialis anterior weight	0.0	0.0	0.0	0.2	-0.1
Time to tail flick, vehicle, before self-admin	2.7	2.8	2.8	1.7	-1.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	0.5	-0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.2	-0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.4	0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	0.9	-0.9	0.9
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	-0.5	0.6
Tibia length	6.2	17.4	18.0	4.2	-4.1
Ambulatory time before self-admin	0.1	0.1	0.1	-0.3	0.2
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	0.1
Bone: tissue strength	3.1	3.0	3.2	1.8	-1.7
Total heroin consumption	1.2	1.4	1.5	1.2	-1.1
Bone: trabecular number	0.7	1.0	1.1	-1.1	1.0
Bone: trabecular spacing	1.6	2.1	2.2	1.5	-1.4
Bone: trabecular thickness	0.0	0.0	0.0	0.1	-0.1
Bone: trabecular tissue density	0.2	0.3	0.3	0.6	-0.5
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	0.2
Number of responses in last shaping day	0.7	0.7	0.8	-0.8	0.9