Hub : Genes

Tmem8b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr5_62735752_62735831 0.1 0.09 8.7e-03 0.01 0 0 0.01 1.6e-02 3.4e-01 2.1e-01 8.6e-02
2 Adipose gene expression Tmem8b 0.06 0.05 7.5e-07 0.07 0.06 0.05 0.07 1.4e-08 4.1e-07 2.1e-06 3.3e-08
3 PL intron excision ratio chr5_62735752_62735831 0.03 0.02 1.6e-04 0.03 0.03 0.04 0.03 3.2e-04 2.0e-04 9.8e-05 1.7e-04
4 PL gene expression Tmem8b 0.09 0.05 3.1e-12 0.12 0.12 0.12 0.12 6.0e-13 1.4e-12 1.4e-12 7.8e-13
5 PL intron excision ratio chr5_62735490_62735629 0.02 0.02 1.2e-03 0.02 0.02 0.02 0.02 2.3e-03 1.9e-03 1.5e-03 3.1e-03
6 NAcc gene expression Tmem8b 0.04 0.02 3.9e-07 0.05 0.04 0.04 0.05 4.1e-08 3.3e-06 2.0e-07 4.3e-08
7 Brain isoform ratio NM_001427449.1 0.03 0.02 4.2e-03 0.01 0.01 0.01 0.01 2.9e-02 2.3e-02 1.8e-02 2.3e-02
8 IC gene expression Tmem8b 0.23 0.1 4.8e-11 0.23 0.24 0.2 0.24 6.3e-10 1.1e-10 6.4e-09 1.9e-10
9 BLA gene expression Tmem8b 0.04 0.03 8.8e-03 0.02 0.01 0 0 4.8e-02 1.0e-01 1.7e-01 1.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.83.23.91.51.81.81.7-1.81.71.9-2.01.9
Area under the delay curve0.71.11.9-0.7-1.0-1.4-1.01.4-1.0-0.71.0-0.9
BMI with tail1.96.78.12.42.52.52.3-2.52.62.8-2.72.8
BMI without tail1.37.07.82.72.62.72.6-2.72.82.6-2.52.5
Body weight2.812.016.14.03.43.53.3-3.53.43.8-3.03.3
Weight adjusted by age0.10.20.60.60.20.40.1-0.40.30.8-0.10.1
Bone surface0.91.72.21.31.31.31.2-1.31.21.5-1.21.4
Bone volume0.81.62.11.01.31.31.2-1.31.21.4-1.41.4
Breakpoint value in progressive ratio session1.52.74.9-0.0-2.0-1.6-2.01.6-1.7-0.92.2-1.7
Number of licking bursts2.16.27.02.32.52.62.6-2.62.52.5-2.52.3
Context. condit. distance diff. score0.00.00.1-0.3-0.2-0.2-0.20.2-0.2-0.2-0.00.1
Locomotion velocity, session 10.40.51.51.2-0.3-0.5-0.40.5-0.40.41.1-0.4
Locomotion distance, session 10.10.10.60.8-0.1-0.10.00.10.10.30.5-0.4
Locomotion velocity, session 23.03.64.11.72.02.02.0-2.01.91.7-2.01.9
Locomotion distance, session 21.01.43.41.81.21.31.3-1.21.31.0-0.4-0.0
Locomotion velocity, session 30.20.20.50.4-0.4-0.4-0.30.4-0.30.00.7-0.4
Locomotion distance, session 31.72.04.21.71.11.21.2-1.21.22.0-1.11.6
Stereotopy head waving bouts, day 30.70.82.00.0-0.7-0.8-0.80.8-0.8-0.71.3-1.4
Stereotopy head waving duration, day 30.60.81.7-0.3-0.7-0.8-0.80.8-0.8-0.91.1-1.3
Locomotion velocity, session 70.10.10.1-0.3-0.4-0.4-0.30.4-0.3-0.30.3-0.2
Locomotion distance, session 70.10.10.40.60.30.30.2-0.30.30.5-0.20.5
Stereotopy head waving bouts, day 71.01.12.21.41.00.90.9-0.90.91.5-0.80.9
Stereotopy head waving duration, day 70.40.40.91.00.80.70.6-0.60.60.7-0.40.3
Locomotion velocity, session 80.40.51.70.3-0.4-0.3-0.30.4-0.4-0.71.1-1.3
Locomotion distance, session 80.10.10.50.70.00.10.1-0.00.10.00.4-0.5
Degree of sensitization distance1.21.32.8-1.0-0.9-1.0-1.01.0-1.0-1.71.2-1.4
Degree of sensitization stereotypy1.51.73.01.21.21.11.1-1.21.11.7-1.31.5
Conditioned locomotion0.20.30.40.1-0.6-0.7-0.60.6-0.60.30.40.1
Cocaine response after cond. corrected2.13.24.0-1.3-1.9-1.9-2.01.9-1.9-1.42.0-1.6
Cocaine response after cond. not corrected2.23.24.9-1.1-1.7-1.8-1.91.8-1.8-1.62.2-2.0
Cocaine response before conditioning0.60.71.10.91.01.01.0-1.00.90.4-0.50.2
Saline control response0.20.31.01.00.50.60.6-0.50.40.50.00.3
Bone: connectivity density1.21.92.71.11.41.31.3-1.31.31.6-1.61.5
Bone: cortical apparent density0.10.20.5-0.20.60.50.5-0.50.40.0-0.70.4
Bone: cortical area2.94.75.81.62.12.42.2-2.42.31.9-2.42.1
Bone: cortical porosity0.10.10.2-0.2-0.4-0.4-0.40.4-0.2-0.30.3-0.4
Bone: cortical porosity0.00.00.10.2-0.0-0.00.00.00.10.2-0.10.1
Bone: cortical thickness1.42.44.20.51.41.61.4-1.61.51.4-2.01.8
Bone: cortical thickness0.10.10.4-0.7-0.4-0.1-0.30.1-0.4-0.60.0-0.1
Bone: cortical tissue density0.10.10.3-0.20.50.40.3-0.40.2-0.1-0.60.3
Condit. Reinf. active minus inactive responses0.60.71.00.91.00.91.0-0.90.80.6-0.70.6
Condit. Reinf. active-inactive response ratio0.50.50.8-0.9-0.6-0.7-0.70.7-0.9-0.80.6-0.6
Condit. Reinf. active responses3.34.25.42.12.32.22.3-2.12.21.7-1.81.6
Condit. Reinf. inactive responses4.05.17.02.22.52.42.5-2.42.61.8-2.11.6
Incentive salience index mean4.35.57.22.72.52.42.5-2.32.42.3-2.01.9
Condit. Reinf. lever presses8.612.919.54.43.83.53.7-3.53.73.7-2.92.9
Condit. Reinf. active minus inactive responses0.71.11.80.71.01.11.1-1.11.01.0-1.11.3
Condit. Reinf. active-inactive response ratio0.20.41.00.10.50.60.5-0.60.50.6-0.81.0
Condit. Reinf. active responses2.23.23.61.71.81.81.9-1.81.91.7-1.71.8
Condit. Reinf. inactive responses2.53.74.61.92.12.02.1-1.92.11.7-1.81.6
Condit. Reinf. lever presses3.44.96.11.72.42.32.4-2.32.51.8-2.32.1
Condit. Reinf. lever reinforcers received2.73.74.31.92.02.02.1-2.02.11.8-1.81.8
Conditioned reinforcement - actives0.00.10.50.1-0.2-0.1-0.30.00.10.7-0.20.6
Conditioned reinforcement - inactives0.20.61.0-0.1-1.0-1.0-1.00.9-0.9-0.30.7-0.2
Conditioned locomotion0.20.31.10.0-0.3-0.4-0.30.4-0.20.8-0.11.0
Patch foraging indifference point 0 sec0.20.51.81.3-0.4-0.6-0.50.5-0.21.30.30.5
Patch foraging indifference point AUC4.611.013.13.63.43.43.4-3.43.33.5-2.83.0
Delay disc. indifference point, 0s delay1.51.62.2-0.7-1.3-1.3-1.31.3-1.2-1.41.5-1.4
Delay disc. indifference point, 16s delay1.62.33.5-0.8-1.6-1.9-1.61.9-1.8-0.71.6-1.1
Delay disc. indifference point, 2s delay0.10.10.20.20.40.10.4-0.10.50.2-0.50.4
Delay disc. indifference point, 24s delay0.10.10.2-0.1-0.3-0.3-0.30.4-0.3-0.50.4-0.4
Delay disc. indifference point, 4s delay0.20.30.9-0.9-0.3-0.7-0.30.6-0.2-0.30.4-0.3
Delay disc. indifference point, 8s delay0.00.00.10.20.1-0.10.10.10.10.0-0.0-0.1
Indifference point function ln k1.44.35.0-1.9-2.2-2.2-2.22.2-2.1-2.01.8-1.9
Indifference point function log k1.44.35.0-1.9-2.2-2.2-2.22.2-2.1-2.01.8-1.9
Patch foraging total patch changes 0 sec0.30.73.01.70.0-0.1-0.00.00.21.7-0.20.9
Patch foraging total patch changes 12 sec2.73.65.71.91.61.71.6-1.81.82.4-1.92.2
Patch foraging total patch changes 18 sec0.40.81.31.20.90.90.9-0.91.01.0-0.70.8
Patch foraging total patch changes 24 sec0.93.15.82.01.61.61.6-1.71.62.4-1.51.9
Patch foraging total patch changes 6 sec1.93.26.82.51.41.31.3-1.31.72.6-1.42.0
Patch foraging time to switch 0 sec1.03.75.8-2.4-1.9-1.8-1.81.8-1.6-2.41.5-2.0
Patch foraging water rate 0 sec0.72.66.71.81.21.11.1-1.21.12.6-1.42.3
Patch foraging water rate 12 sec0.00.10.1-0.2-0.2-0.3-0.30.3-0.30.10.20.2
Patch foraging water rate 18 sec0.51.03.10.40.60.80.7-0.90.61.4-1.31.8
Patch foraging water rate 24 sec0.20.31.1-0.20.30.30.2-0.40.20.6-0.81.1
Patch foraging water rate 6 sec0.40.60.90.60.70.90.8-0.90.40.8-0.50.7
Seeking ratio, delayed vs. immediate footshock3.24.66.31.52.02.11.9-2.12.32.5-2.32.4
Distance traveled before self-admin1.02.13.41.41.51.61.6-1.61.41.8-1.01.0
Distance traveled after self-admin0.71.32.00.71.41.21.4-1.21.30.8-1.10.9
Extensor digitorum longus weight4.618.524.54.94.24.24.3-4.24.34.7-3.93.9
Bone: elastic displacement3.54.48.1-2.8-2.3-2.2-2.22.1-2.2-2.11.4-1.2
Bone: elastic work0.81.04.5-2.1-0.9-0.8-0.90.7-0.8-1.0-0.20.3
Bone: endosteal estimation0.71.83.21.81.41.61.4-1.51.31.1-0.70.8
Bone: endosteal perimeter0.61.53.21.81.21.31.2-1.31.21.3-0.71.0
Epididymis fat weight0.31.52.11.21.41.41.4-1.31.40.6-1.10.8
Delta time in closed arm before/after self-admin1.01.01.5-0.11.01.21.0-1.21.20.4-1.10.9
Delta time in open arm before/after self-admin0.50.61.10.0-0.9-1.1-0.81.1-0.7-0.30.9-0.6
Diff in mean of infusions in LGA sessions0.00.10.5-0.10.10.20.0-0.20.1-0.70.0-0.3
Delay discount exponential model param0.70.91.70.60.91.30.9-1.30.90.6-0.90.7
Extinction: sum of active levers before priming3.14.86.5-1.3-2.3-2.5-2.32.6-1.8-2.22.2-2.2
Active lever presses in extinction session 60.30.30.5-0.5-0.7-0.6-0.70.6-0.4-0.20.4-0.2
Bone: final force1.42.33.41.51.61.91.8-1.81.71.1-1.30.8
Bone: final moment1.32.03.21.21.61.81.7-1.71.60.9-1.20.7
Food consumed during 24 hour testing period0.20.50.91.00.80.80.8-0.80.70.6-0.40.2
Glucose2.74.25.32.32.02.02.0-2.02.22.1-1.82.1
Heart weight0.50.91.71.01.10.91.0-0.91.30.7-0.80.4
Delay discount hyperbolic model param0.50.61.20.50.81.10.8-1.10.70.4-0.80.5
Intermittent access intake day 1-15 change0.21.31.80.61.21.31.2-1.31.10.9-1.31.3
Intermittent access intake escalation0.21.21.70.41.21.31.2-1.31.00.7-1.21.2
Intermittent access intake escalation 21.42.33.20.41.51.71.5-1.71.51.1-1.81.7
Intermitt. access day 1 inactive lever presses0.11.33.92.01.01.01.1-1.01.01.1-0.81.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.1-0.10.1-0.1-0.10.00.10.1-0.1
Intermitt. access escalation Index0.10.41.51.20.60.60.6-0.50.50.2-0.2-0.2
Intermittent access day 1 total infusions0.82.54.5-0.9-2.0-1.9-2.11.8-1.8-0.41.5-0.7
Intermittent access day 15 total infusions0.10.21.00.00.00.2-0.1-0.30.10.7-0.51.0
Intermittent access terminal intake (last 3 days)0.20.31.20.4-0.00.3-0.1-0.40.10.9-0.51.1
Intermittent access total infusions0.20.31.00.4-0.3-0.1-0.4-0.0-0.10.9-0.31.0
Intermittent access day 1 locomotion1.12.03.6-0.7-1.8-1.9-1.81.8-1.5-0.41.1-0.2
Intermittent access day 15 total locomotion0.41.42.5-1.1-1.6-1.3-1.61.2-1.5-0.20.9-0.0
Intermittent access total locomotion1.11.32.2-1.3-1.4-1.3-1.51.3-1.3-0.50.60.2
Intermittent access standard deviation0.10.31.00.30.30.40.3-0.40.61.0-0.60.9
Left kidney weight0.11.03.01.70.91.11.0-1.01.10.9-0.30.3
Right kidney weight0.21.42.71.61.31.21.3-1.21.50.7-0.80.6
Cocaine induced anxiety0.10.31.0-0.5-0.3-0.4-0.30.5-0.7-1.00.5-0.4
Post-drug Anxiety0.20.20.80.90.60.50.6-0.40.3-0.20.1-0.3
Baseline Anxiety0.50.81.41.11.00.91.0-0.81.20.6-0.70.2
Tail length1.16.07.92.72.62.82.7-2.72.62.0-1.81.6
Length with tail0.93.98.42.91.92.02.0-2.01.92.1-1.21.4
Length without tail0.00.10.30.4-0.4-0.3-0.30.3-0.40.30.6-0.2
Times rat made contact with spout0.60.61.10.50.70.80.7-0.80.70.8-1.00.9
Lifetime Intake0.20.30.70.2-0.6-0.3-0.70.3-0.40.80.20.7
Liver weight, left0.10.21.00.2-0.3-0.2-0.30.3-0.2-0.60.6-1.0
Liver weight, right0.71.22.1-1.5-1.2-1.1-1.11.1-1.0-1.10.8-0.7
Locomotor activity0.00.00.30.5-0.0-0.0-0.00.1-0.0-0.10.1-0.2
Locomotor testing distance0.30.71.30.1-0.9-0.8-0.90.9-0.8-0.71.1-1.1
Locomotor testing rearing0.10.51.71.30.60.70.6-0.70.60.3-0.10.1
Locomotion in novel chamber0.10.20.7-0.8-0.2-0.5-0.20.4-0.1-0.3-0.20.2
Locomotion in novel chamber post-restriction1.03.04.90.41.92.21.9-2.21.71.1-1.91.5
Fecal boli incidents, locomotor time 10.20.40.8-0.7-0.6-0.9-0.60.9-0.4-0.80.4-0.4
Change in fecal boli incidents, locomotor task0.30.40.80.90.50.70.5-0.70.30.6-0.30.6
Time >=10cm from walls, locomotor time 10.10.20.30.4-0.4-0.4-0.30.4-0.50.10.5-0.4
Bouts of movement, locomotor time 11.51.92.2-1.3-1.2-1.5-1.31.5-1.4-1.51.2-1.5
Total resting periods, locomotor time 11.72.02.9-1.7-1.3-1.4-1.31.4-1.3-1.61.1-1.4
Rest time, locomotor task time 10.30.52.4-1.5-0.1-0.1-0.10.1-0.1-1.2-0.0-0.5
Distance moved, locomotor task time 10.30.82.71.60.60.70.6-0.70.41.5-0.30.8
Vertical activity count, locomotor time 10.00.31.51.20.00.20.1-0.1-0.30.80.6-0.5
Time >=10cm from walls, locomotor time 20.00.00.10.00.10.30.1-0.20.20.40.1-0.1
Bouts of movement, locomotor time 20.10.40.80.90.70.20.6-0.20.90.7-0.60.5
Total resting periods, locomotor time 20.00.20.40.70.4-0.10.40.00.60.4-0.40.3
Rest time, locomotor task time 20.30.51.2-1.1-0.7-0.6-0.60.6-0.8-0.90.6-0.5
Distance moved, locomotor task time 20.50.71.10.21.01.01.0-1.00.80.6-0.70.4
Vertical activity count, locomotor time 20.10.30.80.30.70.90.6-0.80.50.5-0.1-0.5
Light reinforcement 10.10.62.81.7-0.3-0.2-0.10.3-0.00.11.2-1.0
Light reinforcement 20.41.02.51.3-0.7-0.5-0.50.6-0.7-0.11.6-1.6
Bone: marrow area0.92.13.41.81.61.71.6-1.71.41.2-0.90.9
Bone: maximum diameter2.65.26.22.12.32.52.4-2.52.42.0-2.21.9
Bone: maximum force2.85.67.02.32.52.62.6-2.62.62.0-2.11.7
Bone: maximum moment2.54.76.22.02.32.52.5-2.42.41.8-2.01.5
Mean time between licks in bursts0.21.13.4-0.7-0.7-0.6-0.70.7-0.7-1.71.2-1.8
Mean num. licks in bursts1.02.62.9-1.6-1.6-1.7-1.61.7-1.7-1.71.5-1.5
Cd content in liver0.50.61.11.00.81.10.7-1.00.60.5-0.40.2
Co content in liver1.11.31.9-0.7-1.3-1.0-0.91.1-1.2-1.21.4-1.4
Cu content in liver1.92.33.9-1.7-1.3-1.2-1.31.2-1.5-2.01.4-1.7
Fe content in liver2.02.53.7-1.1-1.7-1.4-1.41.5-1.6-1.81.9-1.7
K content in liver0.50.50.8-0.4-0.7-0.7-0.60.7-0.8-0.50.9-0.9
Mg content in liver0.50.60.8-0.8-0.9-0.9-0.70.8-0.8-0.50.6-0.6
Mn content in liver1.61.82.20.81.51.51.5-1.51.51.1-1.51.1
Na content in liver2.32.55.7-1.6-1.4-1.1-1.11.2-1.4-2.41.7-1.9
Rb content in liver6.77.89.9-3.1-3.0-2.6-2.52.6-2.9-2.82.6-2.8
Se content in liver2.93.55.22.02.32.01.7-1.92.21.3-1.71.5
Sr content in liver0.60.61.61.31.00.60.4-0.61.00.5-0.50.3
Zn content in liver0.10.10.40.10.30.40.6-0.40.3-0.2-0.2-0.0
Bone: minimum diameter0.00.10.1-0.20.10.30.1-0.30.1-0.1-0.30.4
Time in familiar zone, hab. session 10.40.41.4-0.80.30.30.2-0.40.20.1-1.21.1
Time in novel zone, hab. session 13.94.48.6-0.9-1.9-1.9-1.82.0-1.8-2.12.8-2.9
Total zone transitions, hab. session 10.00.00.20.10.20.10.2-0.10.3-0.10.0-0.4
Total locomotion distance, hab. session 10.81.11.70.61.31.21.2-1.21.30.5-1.20.4
Locomotion velocity, hab. session 12.23.14.21.52.11.92.0-1.92.01.3-1.81.0
Time in familiar zone, hab. session 20.20.21.1-1.1-0.2-0.3-0.30.3-0.4-0.6-0.1-0.1
Time in novel zone, hab. session 22.32.53.6-0.9-1.7-1.6-1.71.7-1.6-1.21.9-1.6
Total zone transitions, hab. session 20.20.30.91.00.50.50.6-0.50.60.6-0.1-0.0
Total locomotion distance, hab. session 20.81.11.41.21.21.11.1-1.11.10.9-0.90.6
Locomotion velocity, hab. session 21.21.61.91.41.41.41.3-1.31.31.1-1.10.8
Novel to familiar place preference ratio3.95.16.0-1.9-2.5-2.4-2.32.4-2.3-2.02.4-2.2
Novelty place preference4.96.37.5-2.2-2.7-2.6-2.62.6-2.6-2.32.6-2.3
Time in novel zone, NPP test6.57.99.1-2.5-3.0-2.9-2.82.9-2.9-2.62.9-2.7
Total zone transitions, NPP test0.30.41.41.20.60.50.6-0.50.60.60.0-0.2
Total locomotion distance, NPP test1.41.94.02.01.41.31.4-1.31.41.6-0.91.0
Locomotion velocity, NPP test2.23.15.02.21.81.71.7-1.71.72.0-1.41.4
Intraocular pressure1.93.14.92.11.61.61.5-1.71.62.2-1.51.9
Delta distance traveled before/after self-admin0.00.10.30.20.1-0.10.10.1-0.1-0.50.1-0.4
Delta ambulatory time before/after self-admin0.30.41.3-0.3-0.4-0.5-0.50.6-0.6-1.10.6-0.9
Parametrial fat weight0.30.81.7-0.6-0.8-0.7-0.80.7-0.7-0.91.2-1.3
Pavlov. Cond. lever latency6.38.011.1-3.3-3.0-2.8-2.82.8-2.9-2.92.4-2.4
Pavlov. Cond. magazine entry latency0.50.71.01.01.00.90.9-0.90.90.5-0.60.5
Pavlov. Cond. change in total contacts2.42.63.71.91.71.61.6-1.61.51.7-1.31.5
Pavlov. Cond. index score3.24.15.22.32.32.12.1-2.12.21.8-1.71.6
Pavlov. Cond. latency score3.03.84.82.22.22.02.0-2.02.11.8-1.61.6
Pavlov. Cond. lever contacts6.27.49.53.12.92.72.7-2.72.82.8-2.42.4
Pavlov. Cond. magazine entry number0.81.11.3-1.0-1.2-1.1-1.11.1-1.1-0.81.0-0.9
Pavlov. Cond. intertrial magazine entries0.30.30.50.60.70.60.7-0.60.70.5-0.50.3
Pavlov. Cond. lever-magazine prob. diff.3.54.35.52.22.32.22.2-2.12.21.8-1.81.7
Pavlov. Cond. response bias3.84.76.32.52.42.22.3-2.22.22.0-1.81.7
Pavlov. Cond. lever latency3.14.45.7-1.7-2.3-2.2-2.32.2-2.4-1.62.1-1.9
Pavlov. Cond. magazine entry latency0.20.31.1-0.8-0.3-0.3-0.30.4-0.2-1.00.5-0.9
Pavlov. Cond. change in total contacts0.81.93.00.51.71.61.6-1.61.70.6-1.61.0
Pavlov. Cond. index score0.40.71.10.11.01.01.0-0.91.10.1-0.90.4
Pavlov. Cond. latency score0.61.01.50.21.21.11.1-1.11.20.3-1.10.7
Pavlov. Cond. lever contacts2.33.34.61.42.12.02.0-2.02.11.3-1.81.5
Pavlov. Cond. magazine entry number0.30.40.70.2-0.8-0.7-0.80.7-0.80.10.8-0.3
Pavlov. Cond. intertrial magazine entries0.20.51.10.70.40.60.5-0.60.51.0-0.70.9
Pavlov. Cond. lever-magazine prob. diff.0.50.71.20.11.11.01.0-1.01.10.0-0.90.5
Pavlov. Cond. response bias1.11.62.50.71.51.41.5-1.41.60.6-1.30.8
Time in closed arm before self-admin0.30.41.0-0.8-0.6-1.0-0.60.9-0.8-0.20.20.2
Time in closed arm after self-admin0.20.21.2-1.10.10.30.0-0.3-0.0-0.4-0.40.1
Time in open arm before self-admin0.60.82.21.50.71.10.7-1.10.80.7-0.20.1
Time in open arm after self-admin0.60.62.51.60.40.30.5-0.30.61.2-0.30.6
Bone: periosteal estimation1.53.65.01.92.02.22.0-2.22.01.6-1.71.5
Bone: periosteal perimeter0.30.71.21.10.70.90.8-0.90.80.8-0.60.7
Bone: post-yield work1.32.34.82.21.61.61.6-1.51.61.5-0.90.7
Progressive ratio test 1 active lever presses0.61.12.7-0.4-1.5-1.1-1.61.1-1.40.10.90.1
Progressive ratio test 1 breakpoint0.50.92.2-0.3-1.4-1.0-1.50.9-1.20.20.80.2
Progressive ratio test 1 inactive lever presses0.10.31.81.3-0.00.2-0.1-0.2-0.01.00.20.5
Progressive ratio test 2 active lever presses1.11.53.1-0.4-1.7-1.4-1.81.3-1.4-0.01.3-0.5
Progressive ratio test 2 breakpoint1.31.63.3-0.5-1.7-1.4-1.81.4-1.5-0.11.3-0.5
Progressive ratio test 2 inactive lever presses0.10.30.90.6-0.10.3-0.1-0.30.11.0-0.30.9
Incentive Sensitization - Responses0.30.71.3-0.4-1.1-0.9-1.00.9-1.0-0.31.0-0.6
Incentive Sensitization - Breakpoint0.30.81.4-0.5-1.2-1.0-1.01.0-1.0-0.31.0-0.7
Sum of active levers in priming session hrs 5-64.34.05.6-0.9-2.3-2.4-2.32.3-1.9-1.52.1-1.9
Progressive ratio0.00.00.10.3-0.2-0.3-0.20.30.1-0.00.1-0.0
Food seeking constrained by brief footshock4.86.012.03.42.21.82.2-1.92.33.5-2.02.3
Seeking ratio, punishment vs. effort0.92.03.11.61.51.31.4-1.41.21.8-1.21.3
Retroperitoneal fat weight0.31.43.1-1.6-1.1-0.9-1.00.9-0.9-1.80.8-1.1
Reaction time number correct0.00.10.40.5-0.1-0.00.10.0-0.10.7-0.00.3
Reaction time mean minus median0.21.62.80.51.31.31.5-1.31.70.6-1.70.9
Reaction time mean minus median AUC0.32.33.71.01.51.61.8-1.61.91.0-1.81.2
Reaction time num false alarms0.10.10.40.10.50.40.6-0.40.40.0-0.40.2
Reaction time num false alarms AUC0.20.50.90.70.70.70.9-0.70.80.6-0.70.6
Reaction time trials correct on left0.00.10.40.5-0.1-0.00.10.0-0.10.7-0.00.3
Reaction time trials on left0.00.10.30.4-0.2-0.10.00.1-0.20.60.10.2
Reaction time mean0.30.82.5-1.6-0.6-0.4-0.40.5-0.4-1.50.3-1.0
Reaction time mean AUC0.30.82.8-1.7-0.7-0.5-0.50.5-0.4-1.50.3-1.0
Median of all reaction times1.82.85.3-2.3-1.5-1.3-1.41.3-1.4-2.21.3-1.9
Reaction time omissions1.42.33.2-1.4-1.4-1.5-1.51.5-1.3-1.81.5-1.7
Reaction time false alarm rate0.00.10.1-0.20.30.20.3-0.20.3-0.3-0.20.0
Reaction time premature initiation rate1.31.94.4-2.1-1.5-1.5-1.51.4-1.5-1.30.6-0.4
Reaction time premature initiations0.51.42.7-1.7-1.4-1.4-1.31.3-1.3-0.70.6-0.2
Std. dev. reaction times0.10.30.7-0.30.50.60.7-0.50.8-0.5-0.7-0.1
Reaction time trials completed0.00.10.30.4-0.2-0.10.00.1-0.20.60.10.2
Reaction time trials AUC0.00.10.30.4-0.2-0.10.00.1-0.10.60.00.2
Run reversals in cocaine runway, females0.20.20.70.80.60.50.5-0.50.0-0.1-0.40.1
Run reversals in cocaine runway, males0.00.00.2-0.4-0.3-0.2-0.30.20.1-0.10.00.0
Latency to leave start box in cocaine runway0.50.71.00.50.90.80.8-0.80.70.9-1.00.9
Latency to leave start box in cocaine runway, F0.20.20.3-0.6-0.5-0.5-0.60.5-0.5-0.00.4-0.1
Latency to leave start box in cocaine runway, M1.71.62.21.41.51.31.5-1.31.11.2-1.21.0
Std. dev. time between licks in bursts0.20.40.7-0.6-0.6-0.6-0.60.6-0.6-0.80.6-0.7
Total sessions with >9 infusions0.30.40.80.2-0.8-0.8-0.90.7-0.80.30.70.2
Short access day 1 total inactive lever presses0.20.31.21.1-0.00.1-0.0-0.1-0.30.9-0.00.9
Short access day 10 total inactive lever presses0.10.81.01.01.00.91.0-0.91.00.7-1.00.8
Short access day 1 total infusions0.20.40.80.4-0.9-0.6-0.90.5-0.70.30.80.2
Short access day 10 total infusions0.40.61.20.2-1.0-0.8-1.10.8-1.00.20.9-0.1
Short access total infusions0.81.12.2-0.2-1.4-1.1-1.51.0-1.30.01.2-0.3
Short access day 1 locomotion1.52.43.9-1.0-1.9-2.0-2.01.9-1.6-0.91.5-0.5
Short access day 10 total locomotion0.20.91.6-1.3-0.9-1.3-0.91.2-0.6-0.90.40.1
Short access total locomotion0.60.91.9-0.2-1.1-1.4-1.11.3-1.0-0.50.9-0.0
One hour access (0.3 mA shock)0.10.10.50.4-0.10.3-0.1-0.30.00.7-0.00.4
Compulsive drug intake0.40.61.1-0.20.80.90.9-0.91.10.2-0.90.2
One hour access (shock baseline)0.10.30.80.3-0.8-0.4-0.90.4-0.50.70.60.3
Social response proportion1.82.36.4-1.7-1.1-1.0-1.11.1-1.4-2.51.4-1.8
Social responses0.60.81.21.11.11.01.1-1.01.00.3-0.60.5
Social time0.50.83.20.1-0.2-0.2-0.20.3-0.3-1.51.1-1.8
Soleus weight0.51.43.80.5-0.9-0.8-0.90.9-0.9-1.01.9-1.9
Bone: stiffness3.46.18.52.62.82.92.9-2.82.71.8-1.91.3
Tibialis anterior weight6.221.530.85.54.64.84.7-4.84.64.9-3.83.8
Time to tail flick, vehicle, before self-admin0.30.32.2-1.5-0.5-0.3-0.50.3-0.2-0.2-0.10.2
Time to tail flick, vehicle, after self-admin0.20.31.2-1.10.10.50.2-0.50.30.5-0.50.8
Time to tail flick, test, before self-admin0.40.50.70.90.80.60.8-0.60.70.6-0.70.7
Time to tail flick, test, after self-admin4.04.36.41.42.02.02.0-2.12.11.8-2.42.5
Delta time to tail flick, vehicle, before/after SA0.10.10.30.40.40.60.4-0.50.3-0.0-0.10.0
Delta time to tail flick, test, before/after SA0.20.20.7-0.40.30.40.3-0.40.40.3-0.70.8
Tibia length0.41.04.4-0.1-0.8-0.3-0.50.4-0.6-1.01.5-2.1
Ambulatory time before self-admin0.51.63.11.31.21.41.3-1.41.11.8-0.81.0
Ambulatory time after self-admin0.20.30.40.60.60.70.7-0.60.50.5-0.30.3
Bone: tissue strength0.20.20.70.20.40.40.5-0.30.5-0.50.1-0.8
Total heroin consumption2.52.93.9-0.8-1.9-1.9-2.01.9-1.9-1.21.9-1.5
Bone: trabecular number1.42.63.11.41.81.61.6-1.61.61.6-1.71.4
Bone: trabecular spacing0.00.00.1-0.10.00.20.2-0.20.1-0.2-0.30.2
Bone: trabecular thickness0.00.00.1-0.30.1-0.2-0.20.20.0-0.0-0.10.0
Bone: trabecular tissue density1.83.24.92.22.12.12.1-2.02.01.1-1.10.7
Water consumed over 24 hours0.61.21.60.81.01.11.0-1.10.91.2-1.21.3
Number of responses in last shaping day1.41.93.4-0.2-1.4-1.5-1.51.5-1.5-0.61.9-1.4