Hub : Genes

Tmem86b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tmem86b 0.03 0.02 2.7e-03 0.02 0.02 0.02 0.02 1.1e-02 2.9e-03 4.4e-03 9.0e-03
2 IL gene expression Tmem86b 0.2 0.13 1.0e-03 0.12 0.08 0.1 0.1 7.2e-04 5.3e-03 2.4e-03 2.5e-03
3 PL gene expression Tmem86b 0.04 0.03 7.5e-03 0.02 0.01 0.02 0.01 1.6e-03 3.9e-02 4.4e-03 8.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.10.1-0.30.20.0
Area under the delay curve0.30.51.00.6-1.00.1
BMI with tail0.41.32.01.4-1.2-0.6
BMI without tail0.00.20.3-0.30.60.5
Body weight1.14.96.6-2.22.61.8
Weight adjusted by age0.20.51.0-1.00.5-0.4
Bone surface2.24.46.6-2.42.61.0
Bone volume1.73.34.5-2.12.11.0
Breakpoint value in progressive ratio session0.10.20.50.70.10.0
Number of licking bursts0.00.00.10.3-0.1-0.1
Context. condit. distance diff. score0.30.30.90.20.0-1.0
Locomotion velocity, session 11.61.84.7-0.1-0.9-2.2
Locomotion distance, session 11.41.83.2-1.81.5-0.3
Locomotion velocity, session 20.40.51.00.2-0.6-1.0
Locomotion distance, session 20.91.22.7-1.70.90.4
Locomotion velocity, session 30.00.00.10.2-0.10.2
Locomotion distance, session 30.10.20.2-0.50.5-0.1
Stereotopy head waving bouts, day 30.20.20.40.40.3-0.7
Stereotopy head waving duration, day 30.10.20.30.40.2-0.6
Locomotion velocity, session 70.20.20.3-0.20.4-0.5
Locomotion distance, session 70.40.51.3-0.1-0.3-1.2
Stereotopy head waving bouts, day 70.50.61.5-0.31.20.3
Stereotopy head waving duration, day 70.40.51.1-0.41.10.3
Locomotion velocity, session 80.30.30.9-0.00.2-0.9
Locomotion distance, session 80.20.30.5-0.50.3-0.7
Degree of sensitization distance0.10.10.4-0.00.1-0.6
Degree of sensitization stereotypy0.20.20.5-0.10.70.5
Conditioned locomotion0.50.61.5-0.20.5-1.2
Cocaine response after cond. corrected1.21.92.31.5-1.51.0
Cocaine response after cond. not corrected0.40.61.8-0.1-0.21.4
Cocaine response before conditioning4.95.99.8-3.12.80.5
Saline control response0.71.02.5-0.30.6-1.6
Bone: connectivity density0.00.10.10.2-0.3-0.2
Bone: cortical apparent density0.30.51.1-0.2-1.1-0.7
Bone: cortical area0.81.32.4-1.21.60.3
Bone: cortical porosity0.30.30.70.90.40.3
Bone: cortical porosity0.50.60.90.51.00.8
Bone: cortical thickness0.30.50.80.7-0.4-0.9
Bone: cortical thickness0.20.30.5-0.4-0.4-0.7
Bone: cortical tissue density0.30.51.2-0.2-1.1-0.5
Condit. Reinf. active minus inactive responses0.30.40.80.50.10.9
Condit. Reinf. active-inactive response ratio1.01.02.01.4-1.00.5
Condit. Reinf. active responses0.30.41.0-0.31.00.5
Condit. Reinf. inactive responses2.43.15.1-2.02.3-0.1
Incentive salience index mean0.40.51.1-0.30.41.1
Condit. Reinf. lever presses0.50.71.1-1.10.40.9
Condit. Reinf. active minus inactive responses2.74.16.5-2.42.60.4
Condit. Reinf. active-inactive response ratio3.14.96.8-2.62.61.1
Condit. Reinf. active responses2.84.07.0-2.22.7-0.1
Condit. Reinf. inactive responses0.30.40.9-0.20.9-0.5
Condit. Reinf. lever presses1.42.03.4-0.81.81.4
Condit. Reinf. lever reinforcers received3.55.08.6-2.52.9-0.1
Conditioned reinforcement - actives0.10.20.4-0.4-0.60.4
Conditioned reinforcement - inactives0.51.33.6-1.90.50.4
Conditioned locomotion0.00.10.1-0.3-0.10.3
Patch foraging indifference point 0 sec0.30.71.10.6-0.9-1.0
Patch foraging indifference point AUC0.30.71.01.0-0.9-0.5
Delay disc. indifference point, 0s delay0.30.30.7-0.1-0.5-0.8
Delay disc. indifference point, 16s delay0.50.61.11.0-0.30.9
Delay disc. indifference point, 2s delay1.31.53.80.7-1.9-0.3
Delay disc. indifference point, 24s delay0.30.50.90.9-0.50.7
Delay disc. indifference point, 4s delay0.20.20.4-0.2-0.30.6
Delay disc. indifference point, 8s delay0.10.10.40.3-0.6-0.1
Indifference point function ln k1.85.59.0-3.02.70.4
Indifference point function log k1.85.59.0-3.02.70.4
Patch foraging total patch changes 0 sec0.20.71.10.6-0.8-1.0
Patch foraging total patch changes 12 sec0.20.20.40.6-0.50.1
Patch foraging total patch changes 18 sec0.30.61.00.9-1.0-0.4
Patch foraging total patch changes 24 sec0.10.41.20.10.21.1
Patch foraging total patch changes 6 sec0.61.01.51.2-1.1-0.6
Patch foraging time to switch 0 sec1.14.45.82.2-1.62.4
Patch foraging water rate 0 sec0.31.32.1-1.10.8-1.4
Patch foraging water rate 12 sec0.62.54.1-2.01.6-1.0
Patch foraging water rate 18 sec0.71.51.8-1.31.1-1.3
Patch foraging water rate 24 sec0.71.01.5-1.20.9-0.8
Patch foraging water rate 6 sec4.46.59.0-3.02.91.4
Seeking ratio, delayed vs. immediate footshock0.50.82.0-0.40.4-1.4
Distance traveled before self-admin0.81.83.1-1.81.1-1.0
Distance traveled after self-admin0.61.02.80.30.5-1.7
Extensor digitorum longus weight0.20.91.3-0.91.20.7
Bone: elastic displacement0.30.30.60.60.2-0.8
Bone: elastic work0.30.40.7-0.80.5-0.3
Bone: endosteal estimation1.94.56.9-2.62.31.3
Bone: endosteal perimeter1.33.24.5-2.12.10.8
Epididymis fat weight0.20.92.60.20.31.6
Delta time in closed arm before/after self-admin0.40.41.00.3-1.0-0.3
Delta time in open arm before/after self-admin1.82.14.3-1.42.1-0.4
Diff in mean of infusions in LGA sessions0.20.30.4-0.3-0.6-0.7
Delay discount exponential model param0.30.30.8-0.50.9-0.2
Extinction: sum of active levers before priming0.00.10.10.20.3-0.3
Active lever presses in extinction session 60.20.20.50.40.30.7
Bone: final force1.11.74.0-2.01.00.5
Bone: final moment1.32.25.1-2.31.10.3
Food consumed during 24 hour testing period0.81.52.6-1.61.30.6
Glucose1.72.62.81.6-1.7-1.6
Heart weight1.32.12.6-1.41.61.4
Delay discount hyperbolic model param0.40.51.2-0.61.1-0.2
Intermittent access intake day 1-15 change0.10.61.1-1.00.80.5
Intermittent access intake escalation0.21.21.6-1.31.10.8
Intermittent access intake escalation 20.10.20.2-0.50.4-0.3
Intermitt. access day 1 inactive lever presses0.11.61.9-1.41.31.1
Intermitt. access day 15 inactive lever presses0.52.73.7-1.81.91.1
Intermitt. access escalation Index0.20.60.70.7-0.8-0.7
Intermittent access day 1 total infusions0.10.20.5-0.70.10.2
Intermittent access day 15 total infusions0.20.61.2-1.10.40.6
Intermittent access terminal intake (last 3 days)0.30.41.1-1.00.10.5
Intermittent access total infusions0.60.71.7-1.30.20.5
Intermittent access day 1 locomotion0.30.51.5-1.20.10.4
Intermittent access day 15 total locomotion0.20.92.3-1.50.2-0.5
Intermittent access total locomotion1.41.64.2-2.00.70.4
Intermittent access standard deviation0.10.40.60.4-0.8-0.7
Left kidney weight2.519.728.6-5.15.32.1
Right kidney weight3.020.929.9-5.05.52.8
Cocaine induced anxiety0.61.63.6-1.11.90.2
Post-drug Anxiety1.21.33.3-0.61.80.6
Baseline Anxiety0.40.61.10.9-1.00.1
Tail length2.010.814.4-3.73.82.1
Length with tail2.812.515.8-3.74.02.9
Length without tail1.05.25.8-2.02.42.4
Times rat made contact with spout0.10.10.20.3-0.10.5
Lifetime Intake0.30.41.1-1.0-0.10.4
Liver weight, left0.91.52.1-1.31.40.8
Liver weight, right0.00.10.2-0.10.20.4
Locomotor activity0.10.10.10.4-0.30.4
Locomotor testing distance0.10.20.70.00.20.8
Locomotor testing rearing0.20.71.1-0.81.10.5
Locomotion in novel chamber1.11.52.01.2-1.4-1.0
Locomotion in novel chamber post-restriction0.41.12.50.9-1.6-0.1
Fecal boli incidents, locomotor time 10.10.20.4-0.70.1-0.1
Change in fecal boli incidents, locomotor task2.83.04.91.7-2.2-1.0
Time >=10cm from walls, locomotor time 10.00.00.00.2-0.20.1
Bouts of movement, locomotor time 10.81.02.3-0.80.3-1.5
Total resting periods, locomotor time 10.50.61.7-0.2-0.2-1.3
Rest time, locomotor task time 10.50.81.6-1.30.60.6
Distance moved, locomotor task time 10.30.81.81.3-0.5-0.6
Vertical activity count, locomotor time 10.42.83.51.7-1.5-1.9
Time >=10cm from walls, locomotor time 20.20.71.11.1-0.9-0.2
Bouts of movement, locomotor time 20.00.00.0-0.10.00.1
Total resting periods, locomotor time 20.00.00.0-0.2-0.2-0.0
Rest time, locomotor task time 20.10.10.2-0.2-0.3-0.4
Distance moved, locomotor task time 20.10.10.20.50.1-0.3
Vertical activity count, locomotor time 20.10.30.60.4-0.4-0.7
Light reinforcement 10.20.71.80.0-0.5-1.3
Light reinforcement 21.02.32.71.4-1.6-1.5
Bone: marrow area1.94.66.9-2.62.31.3
Bone: maximum diameter1.02.03.2-1.41.81.0
Bone: maximum force1.73.46.1-2.51.80.9
Bone: maximum moment2.03.77.1-2.71.90.7
Mean time between licks in bursts0.21.11.60.8-1.0-1.3
Mean num. licks in bursts0.10.20.5-0.30.10.7
Cd content in liver1.61.72.8-1.71.5-0.5
Co content in liver1.01.22.5-1.1-0.2-1.6
Cu content in liver0.50.61.1-1.00.8-0.3
Fe content in liver0.20.20.4-0.60.5-0.2
K content in liver0.10.10.10.00.4-0.3
Mg content in liver0.10.10.20.40.10.1
Mn content in liver0.50.50.90.21.00.8
Na content in liver1.61.83.61.9-1.0-0.8
Rb content in liver2.93.45.4-1.72.31.4
Se content in liver1.01.22.91.7-0.7-0.6
Sr content in liver6.25.37.32.1-2.7-2.1
Zn content in liver0.40.40.70.8-0.70.3
Bone: minimum diameter2.85.37.9-2.62.81.1
Time in familiar zone, hab. session 11.92.14.2-2.10.7-1.3
Time in novel zone, hab. session 11.11.23.31.8-0.7-0.0
Total zone transitions, hab. session 10.40.61.1-1.00.3-0.8
Total locomotion distance, hab. session 10.30.41.0-0.6-0.1-1.0
Locomotion velocity, hab. session 10.10.20.4-0.5-0.1-0.6
Time in familiar zone, hab. session 22.22.53.1-1.81.51.4
Time in novel zone, hab. session 21.31.42.21.5-1.0-1.0
Total zone transitions, hab. session 21.72.13.2-1.81.80.2
Total locomotion distance, hab. session 20.10.10.2-0.2-0.0-0.5
Locomotion velocity, hab. session 20.10.10.4-0.1-0.1-0.6
Novel to familiar place preference ratio0.10.10.2-0.10.40.2
Novelty place preference0.10.20.4-0.40.60.2
Time in novel zone, NPP test0.20.20.4-0.40.60.2
Total zone transitions, NPP test0.10.20.5-0.70.20.0
Total locomotion distance, NPP test0.30.40.5-0.70.70.6
Locomotion velocity, NPP test0.30.40.6-0.70.80.4
Intraocular pressure0.10.10.20.2-0.30.5
Delta distance traveled before/after self-admin1.01.12.71.6-0.7-0.4
Delta ambulatory time before/after self-admin0.61.02.01.4-0.9-0.6
Parametrial fat weight1.22.84.52.1-1.9-0.6
Pavlov. Cond. lever latency0.20.20.40.3-0.2-0.7
Pavlov. Cond. magazine entry latency0.50.71.01.0-0.90.4
Pavlov. Cond. change in total contacts0.30.30.60.5-0.7-0.1
Pavlov. Cond. index score0.30.30.60.6-0.80.2
Pavlov. Cond. latency score0.20.30.50.5-0.70.3
Pavlov. Cond. lever contacts0.40.41.1-0.30.41.0
Pavlov. Cond. magazine entry number0.30.30.4-0.60.6-0.5
Pavlov. Cond. intertrial magazine entries1.21.44.2-0.00.2-2.1
Pavlov. Cond. lever-magazine prob. diff.0.30.30.50.6-0.70.2
Pavlov. Cond. response bias0.30.41.10.2-0.21.0
Pavlov. Cond. lever latency0.10.20.4-0.6-0.20.3
Pavlov. Cond. magazine entry latency0.40.51.21.1-0.4-0.5
Pavlov. Cond. change in total contacts0.30.71.3-0.41.2-0.7
Pavlov. Cond. index score0.10.10.30.30.5-0.2
Pavlov. Cond. latency score0.10.20.60.80.1-0.3
Pavlov. Cond. lever contacts0.10.10.30.30.5-0.2
Pavlov. Cond. magazine entry number0.30.40.6-0.80.50.6
Pavlov. Cond. intertrial magazine entries1.63.45.0-2.22.10.9
Pavlov. Cond. lever-magazine prob. diff.0.10.20.20.40.3-0.5
Pavlov. Cond. response bias0.30.41.0-0.31.00.0
Time in closed arm before self-admin0.61.01.6-1.01.20.7
Time in closed arm after self-admin0.30.30.8-0.1-0.10.9
Time in open arm before self-admin2.02.54.21.6-2.1-0.7
Time in open arm after self-admin0.50.51.50.30.1-1.2
Bone: periosteal estimation1.53.75.2-2.32.30.8
Bone: periosteal perimeter1.32.64.1-1.92.00.3
Bone: post-yield work2.23.95.5-2.12.41.2
Progressive ratio test 1 active lever presses0.30.41.0-1.00.0-0.6
Progressive ratio test 1 breakpoint0.20.41.0-1.0-0.0-0.5
Progressive ratio test 1 inactive lever presses0.61.64.0-2.00.80.4
Progressive ratio test 2 active lever presses0.20.40.5-0.70.20.7
Progressive ratio test 2 breakpoint0.40.50.7-0.80.30.8
Progressive ratio test 2 inactive lever presses0.72.34.8-2.21.30.5
Incentive Sensitization - Responses0.61.82.0-1.21.41.3
Incentive Sensitization - Breakpoint0.61.31.5-1.01.21.2
Sum of active levers in priming session hrs 5-60.10.10.40.00.6-0.1
Progressive ratio0.10.30.6-0.10.6-0.8
Food seeking constrained by brief footshock2.22.77.7-0.7-0.2-2.8
Seeking ratio, punishment vs. effort0.10.30.9-0.90.2-0.0
Retroperitoneal fat weight2.711.920.54.5-3.90.1
Reaction time number correct0.30.92.50.4-0.4-1.6
Reaction time mean minus median0.00.00.0-0.00.00.1
Reaction time mean minus median AUC0.00.00.00.1-0.1-0.1
Reaction time num false alarms0.00.10.1-0.0-0.2-0.4
Reaction time num false alarms AUC0.30.61.20.3-0.7-1.1
Reaction time trials correct on left0.30.92.50.4-0.4-1.6
Reaction time trials on left0.31.02.60.4-0.4-1.6
Reaction time mean0.51.11.7-0.90.91.3
Reaction time mean AUC0.30.71.5-0.40.51.2
Median of all reaction times0.71.11.9-0.80.91.4
Reaction time omissions0.30.41.00.1-0.5-1.0
Reaction time false alarm rate0.10.10.20.1-0.5-0.3
Reaction time premature initiation rate0.30.41.2-0.10.21.1
Reaction time premature initiations0.00.10.20.2-0.10.4
Std. dev. reaction times0.20.70.8-0.70.80.9
Reaction time trials completed0.31.02.60.4-0.4-1.6
Reaction time trials AUC0.20.61.70.3-0.3-1.3
Run reversals in cocaine runway, females0.70.71.6-0.40.71.2
Run reversals in cocaine runway, males0.10.10.2-0.1-0.50.3
Latency to leave start box in cocaine runway0.30.40.6-0.80.50.6
Latency to leave start box in cocaine runway, F0.00.10.1-0.3-0.00.3
Latency to leave start box in cocaine runway, M1.31.21.5-1.21.11.0
Std. dev. time between licks in bursts0.81.54.30.1-0.3-2.1
Total sessions with >9 infusions0.40.51.3-1.20.2-0.1
Short access day 1 total inactive lever presses0.40.91.7-0.90.51.3
Short access day 10 total inactive lever presses0.00.20.5-0.50.10.7
Short access day 1 total infusions0.10.20.6-0.1-0.80.0
Short access day 10 total infusions0.20.30.80.1-0.9-0.3
Short access total infusions0.40.61.80.2-1.3-0.0
Short access day 1 locomotion0.20.40.7-0.6-0.30.9
Short access day 10 total locomotion0.10.61.4-1.20.1-0.6
Short access total locomotion0.40.60.7-0.7-0.7-0.8
One hour access (0.3 mA shock)2.32.85.1-2.31.70.6
Compulsive drug intake1.52.24.1-1.62.0-0.1
One hour access (shock baseline)0.10.30.6-0.4-0.30.8
Social response proportion1.21.52.8-0.81.01.7
Social responses2.73.53.9-1.92.01.7
Social time2.13.35.5-2.32.1-0.3
Soleus weight0.10.20.2-0.30.50.4
Bone: stiffness1.42.64.8-2.21.70.2
Tibialis anterior weight0.41.42.71.6-1.20.4
Time to tail flick, vehicle, before self-admin0.30.40.6-0.80.6-0.5
Time to tail flick, vehicle, after self-admin0.51.12.9-0.50.41.7
Time to tail flick, test, before self-admin0.70.81.30.0-1.1-1.1
Time to tail flick, test, after self-admin0.10.10.30.60.00.2
Delta time to tail flick, vehicle, before/after SA0.80.91.70.4-0.91.3
Delta time to tail flick, test, before/after SA0.50.71.4-0.11.20.8
Tibia length3.39.212.8-3.23.62.1
Ambulatory time before self-admin0.61.72.6-1.61.4-0.6
Ambulatory time after self-admin0.91.42.7-0.31.1-1.6
Bone: tissue strength0.70.71.7-0.6-0.4-1.3
Total heroin consumption0.10.10.20.10.5-0.1
Bone: trabecular number0.10.30.50.4-0.7-0.3
Bone: trabecular spacing0.10.10.20.00.00.5
Bone: trabecular thickness0.00.00.0-0.0-0.00.2
Bone: trabecular tissue density0.40.61.31.1-0.40.6
Water consumed over 24 hours0.30.61.4-1.20.6-0.2
Number of responses in last shaping day0.30.40.70.1-0.70.8