Tmem198b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Tmem198b	0.11	0.08	1.2e-06	0.04	0.05	0.04	0.04	8.2e-05	1.0e-05	1.9e-04	5.6e-05
2	NAcc	gene expression	Tmem198b	0.04	0.03	4.0e-04	0.03	0.02	0.02	0.02	4.3e-04	8.1e-04	1.6e-03	9.2e-04
3	BLA	gene expression	Tmem198b	0.06	0.05	7.1e-03	0.04	0.03	0.03	0.03	3.4e-03	1.1e-02	1.6e-02	1.2e-02
4	NAcc	alternative TSS	XM_039079728.1	0.02	0.02	8.4e-03	0.02	0.01	0	0.01	4.2e-03	5.7e-03	1.5e-01	8.1e-03
5	BLA	mRNA stability	Tmem198b	0.05	0.04	7.1e-03	0.02	0.01	0.02	0.02	1.8e-02	6.5e-02	4.5e-02	3.5e-02
6	PL	mRNA stability	Tmem198b	0.06	0.04	2.7e-05	0.05	0.04	0.04	0.05	4.5e-06	3.3e-05	3.8e-05	6.8e-06
7	Brain	mRNA stability	Tmem198b	0.23	0.13	4.6e-12	0.09	0.1	0.11	0.1	8.0e-09	3.2e-09	4.9e-10	1.2e-09
8	LHb	mRNA stability	Tmem198b	0.15	0.11	5.7e-03	0.09	0.06	0.09	0.06	4.5e-03	1.5e-02	3.5e-03	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.6	1.0	2.8	-0.4	-0.9	-0.8	-1.1	-1.1	-1.0	-0.1	-1.7
Area under the delay curve	0.2	0.2	0.4	0.3	-0.6	-0.6	0.4	0.3	0.2	0.7	0.1
BMI with tail	7.4	24.1	27.1	5.2	-5.2	-5.1	4.7	4.8	4.8	5.0	4.2
BMI without tail	1.6	3.3	3.9	1.9	-1.7	-1.6	1.9	2.0	1.9	1.8	1.8
Body weight	1.6	6.7	7.7	2.6	-2.7	-2.6	2.6	2.6	2.6	2.8	2.2
Weight adjusted by age	0.1	0.1	0.2	0.1	0.3	0.3	0.2	0.2	0.4	0.1	0.4
Bone surface	1.8	3.2	8.7	-1.1	-0.5	-0.5	-2.2	-2.3	-2.0	-1.0	-2.9
Bone volume	1.5	2.6	7.4	-0.8	-0.9	-0.8	-1.9	-2.0	-1.8	-0.7	-2.7
Breakpoint value in progressive ratio session	2.0	2.2	4.1	-1.5	2.0	1.9	-1.2	-1.2	-1.2	-1.5	-0.9
Number of licking bursts	4.2	5.0	6.3	2.3	-1.8	-2.0	2.3	2.5	2.4	2.2	2.3
Context. condit. distance diff. score	0.2	0.3	0.4	0.6	-0.4	-0.4	0.6	0.6	0.5	0.4	0.6
Locomotion velocity, session 1	0.2	0.3	0.8	0.3	-0.9	-0.9	-0.0	0.0	-0.1	0.5	-0.4
Locomotion distance, session 1	0.5	0.6	1.7	-0.6	-0.1	-0.2	-0.9	-0.9	-1.0	-0.5	-1.3
Locomotion velocity, session 2	2.1	2.5	4.5	-1.5	0.8	0.7	-1.9	-1.9	-1.8	-1.3	-2.1
Locomotion distance, session 2	2.5	3.5	6.0	-2.0	1.0	1.0	-2.2	-2.2	-2.1	-1.5	-2.4
Locomotion velocity, session 3	4.3	5.1	5.9	-2.4	2.4	2.3	-2.2	-2.2	-2.2	-2.3	-1.9
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1	-0.1	-0.0	-0.1	-0.0
Stereotopy head waving bouts, day 3	6.6	7.7	8.7	-2.9	2.6	2.6	-2.9	-2.9	-2.8	-2.8	-2.7
Stereotopy head waving duration, day 3	5.3	6.4	7.3	-2.5	2.4	2.4	-2.6	-2.6	-2.6	-2.7	-2.3
Locomotion velocity, session 7	0.2	0.2	0.4	-0.3	0.3	0.2	-0.4	-0.4	-0.6	-0.5	-0.5
Locomotion distance, session 7	0.2	0.2	0.5	0.4	0.0	0.0	0.6	0.6	0.4	0.2	0.7
Stereotopy head waving bouts, day 7	1.0	1.1	2.1	-1.0	0.5	0.4	-1.2	-1.3	-1.2	-0.8	-1.5
Stereotopy head waving duration, day 7	0.8	0.9	2.1	-0.9	0.2	0.2	-1.1	-1.1	-1.2	-0.6	-1.4
Locomotion velocity, session 8	1.3	1.5	3.4	-1.2	0.3	0.3	-1.5	-1.5	-1.5	-0.8	-1.8
Locomotion distance, session 8	0.2	0.3	0.5	-0.6	0.3	0.3	-0.6	-0.6	-0.6	-0.4	-0.7
Degree of sensitization distance	0.5	0.5	0.6	0.8	-0.7	-0.7	0.7	0.8	0.6	0.7	0.6
Degree of sensitization stereotypy	0.2	0.2	0.7	0.3	-0.8	-0.8	0.2	0.1	0.1	0.5	-0.2
Conditioned locomotion	1.7	2.0	3.4	1.4	-0.7	-0.8	1.7	1.7	1.6	1.3	1.9
Cocaine response after cond. corrected	3.0	3.3	4.8	1.8	-1.2	-1.3	2.0	2.0	2.1	1.7	2.2
Cocaine response after cond. not corrected	2.9	3.2	4.9	1.8	-1.1	-1.1	2.0	2.0	2.1	1.6	2.2
Cocaine response before conditioning	0.7	0.9	1.2	-0.9	0.8	0.9	-0.9	-1.1	-1.0	-0.9	-1.0
Saline control response	0.6	0.8	1.0	0.8	-0.8	-0.8	0.9	0.8	1.0	0.9	0.9
Bone: connectivity density	0.4	0.6	1.8	-0.4	-0.6	-0.4	-0.9	-0.9	-0.8	-0.2	-1.3
Bone: cortical apparent density	1.1	1.5	1.8	1.4	-1.3	-1.2	1.2	1.2	1.2	1.2	1.1
Bone: cortical area	0.4	0.6	2.0	0.8	-1.3	-1.4	0.1	0.1	0.2	0.6	-0.3
Bone: cortical porosity	0.2	0.3	0.5	-0.4	0.2	0.2	-0.6	-0.7	-0.5	-0.4	-0.7
Bone: cortical porosity	0.1	0.2	0.5	-0.1	-0.4	-0.3	-0.5	-0.5	-0.3	-0.1	-0.7
Bone: cortical thickness	0.8	1.3	2.4	1.3	-1.5	-1.6	0.9	0.8	0.9	1.1	0.6
Bone: cortical thickness	0.9	1.1	1.4	1.1	-0.8	-0.9	1.2	1.2	1.0	0.9	1.2
Bone: cortical tissue density	0.9	1.1	1.3	1.2	-1.1	-1.0	1.0	1.0	1.1	1.0	1.0
Condit. Reinf. active minus inactive responses	2.4	2.7	3.1	-1.7	1.7	1.5	-1.6	-1.6	-1.7	-1.8	-1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	-0.6	1.0	0.9	-0.5	-0.5	-0.5	-0.8	-0.3
Condit. Reinf. active responses	3.5	4.3	5.1	-2.1	1.8	1.7	-2.2	-2.2	-2.3	-2.1	-2.2
Condit. Reinf. inactive responses	1.7	2.0	3.2	-1.4	0.9	0.9	-1.6	-1.6	-1.7	-1.3	-1.8
Incentive salience index mean	1.5	1.9	2.5	-1.4	1.1	0.9	-1.5	-1.5	-1.6	-1.3	-1.6
Condit. Reinf. lever presses	0.5	0.6	1.8	-0.5	-0.3	-0.4	-0.9	-0.9	-1.0	-0.2	-1.4
Condit. Reinf. active minus inactive responses	2.2	2.7	4.7	-1.7	2.2	2.2	-1.4	-1.3	-1.3	-1.8	-0.9
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.7	-0.5	1.3	1.3	-0.0	-0.1	-0.1	-0.7	0.4
Condit. Reinf. active responses	1.9	2.7	3.2	-1.7	1.8	1.8	-1.7	-1.6	-1.5	-1.7	-1.3
Condit. Reinf. inactive responses	0.6	0.8	1.3	-0.9	0.5	0.5	-1.1	-1.0	-0.9	-0.8	-1.1
Condit. Reinf. lever presses	2.6	3.5	5.5	-2.0	2.2	2.3	-1.8	-1.7	-1.5	-1.9	-1.3
Condit. Reinf. lever reinforcers received	1.3	1.8	2.7	-1.4	1.6	1.6	-1.3	-1.2	-1.1	-1.4	-0.9
Conditioned reinforcement - actives	0.7	0.7	1.2	-0.6	0.3	0.5	-1.1	-1.1	-0.8	-0.8	-1.0
Conditioned reinforcement - inactives	0.5	0.6	1.3	0.8	-0.1	0.0	0.9	0.9	1.0	0.5	1.2
Conditioned locomotion	5.1	6.1	7.2	-2.4	2.5	2.6	-2.5	-2.5	-2.4	-2.7	-2.2
Patch foraging indifference point 0 sec	2.7	4.4	5.7	2.3	-2.4	-2.3	1.9	1.9	2.0	2.2	1.6
Patch foraging indifference point AUC	0.3	0.3	0.5	-0.7	0.6	0.7	-0.5	-0.5	-0.5	-0.5	-0.4
Delay disc. indifference point, 0s delay	1.7	1.8	4.4	1.2	-2.1	-2.1	0.8	0.8	0.7	1.6	0.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.4	0.4	0.4	-0.3	-0.4	-0.5	-0.3	-0.4
Delay disc. indifference point, 2s delay	0.5	0.5	1.1	0.6	-1.0	-1.0	0.5	0.6	0.4	0.8	0.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.3	0.8	-0.9	-0.9	0.9	0.8	0.8	1.1	0.6
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	-0.6	-0.0	0.0	-0.7	-0.7	-0.7	-0.3	-1.0
Delay disc. indifference point, 8s delay	0.5	0.5	0.7	0.6	-0.5	-0.4	0.8	0.7	0.8	0.9	0.8
Indifference point function ln k	0.0	0.0	0.1	0.3	-0.0	-0.0	0.2	0.3	0.2	-0.0	0.2
Indifference point function log k	0.0	0.0	0.1	0.3	-0.0	-0.0	0.2	0.3	0.2	-0.0	0.2
Patch foraging total patch changes 0 sec	2.5	4.0	5.1	2.3	-2.2	-2.2	1.9	1.9	2.0	2.0	1.6
Patch foraging total patch changes 12 sec	2.0	2.6	3.5	1.6	-1.4	-1.3	1.7	1.6	1.9	1.7	1.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.1	0.2	-0.2	-0.2	0.4	0.2	0.2	0.3	0.2
Patch foraging total patch changes 24 sec	0.6	0.8	1.2	0.9	-1.1	-1.0	0.9	0.6	0.8	1.0	0.5
Patch foraging total patch changes 6 sec	1.4	2.1	2.7	1.6	-1.6	-1.6	1.4	1.3	1.4	1.4	1.2
Patch foraging time to switch 0 sec	0.3	0.5	1.4	0.5	-1.1	-1.2	0.3	0.1	0.3	0.8	-0.1
Patch foraging water rate 0 sec	0.6	0.9	1.8	0.9	-0.3	-0.2	1.1	1.2	1.1	0.7	1.3
Patch foraging water rate 12 sec	0.9	1.3	2.3	1.2	-0.4	-0.4	1.4	1.5	1.3	0.9	1.5
Patch foraging water rate 18 sec	0.6	0.7	1.9	0.3	0.9	0.9	0.8	0.9	0.8	-0.0	1.4
Patch foraging water rate 24 sec	2.6	3.6	7.5	1.7	-0.3	-0.4	2.3	2.4	2.3	1.4	2.7
Patch foraging water rate 6 sec	0.6	0.9	2.7	-0.7	1.6	1.6	-0.2	-0.2	-0.3	-1.1	0.3
Seeking ratio, delayed vs. immediate footshock	2.3	2.7	3.3	-1.6	1.3	1.4	-1.8	-1.8	-1.7	-1.7	-1.7
Distance traveled before self-admin	0.8	0.9	1.1	-1.0	0.9	0.9	-0.8	-1.0	-1.0	-1.0	-0.9
Distance traveled after self-admin	0.3	0.4	0.6	-0.6	0.4	0.5	-0.7	-0.8	-0.6	-0.6	-0.7
Extensor digitorum longus weight	6.1	24.2	27.5	5.1	-4.6	-4.5	5.0	5.0	5.2	5.0	4.8
Bone: elastic displacement	0.0	0.0	0.1	-0.1	0.2	0.1	-0.2	-0.2	-0.3	-0.3	-0.2
Bone: elastic work	0.5	0.6	1.6	0.8	-1.1	-1.2	0.5	0.5	0.5	0.8	0.2
Bone: endosteal estimation	0.2	0.5	1.5	0.9	-1.1	-1.2	0.4	0.4	0.4	0.6	0.1
Bone: endosteal perimeter	0.6	1.3	2.4	-0.9	0.5	0.4	-1.4	-1.4	-1.3	-1.1	-1.5
Epididymis fat weight	0.0	0.1	0.2	-0.2	0.4	0.4	0.0	0.0	-0.2	-0.2	0.1
Delta time in closed arm before/after self-admin	1.5	1.4	3.5	0.9	0.1	0.1	1.4	1.4	1.5	0.7	1.9
Delta time in open arm before/after self-admin	2.1	2.0	3.1	1.4	-1.8	-1.8	1.4	1.2	1.2	1.6	1.0
Diff in mean of infusions in LGA sessions	2.4	2.6	3.6	-1.7	1.9	1.9	-1.5	-1.5	-1.4	-1.7	-1.2
Delay discount exponential model param	0.2	0.2	0.4	-0.3	0.5	0.5	-0.3	-0.3	-0.2	-0.6	-0.1
Extinction: sum of active levers before priming	1.8	1.8	3.8	-1.5	1.9	1.9	-0.9	-0.9	-1.1	-1.4	-0.5
Active lever presses in extinction session 6	0.8	0.8	1.1	-1.0	0.8	0.7	-0.9	-0.9	-1.0	-0.8	-0.9
Bone: final force	2.0	3.2	6.5	1.9	-2.5	-2.5	1.3	1.2	1.4	1.9	0.7
Bone: final moment	1.8	3.0	6.1	1.9	-2.5	-2.4	1.2	1.2	1.3	1.8	0.7
Food consumed during 24 hour testing period	0.4	0.5	0.7	0.7	-0.8	-0.8	0.6	0.6	0.8	0.8	0.5
Glucose	2.1	3.2	3.6	1.9	-1.7	-1.7	1.9	1.8	1.8	1.9	1.6
Heart weight	0.0	0.0	0.1	0.0	0.2	0.2	0.2	0.2	0.1	-0.1	0.3
Delay discount hyperbolic model param	0.3	0.3	0.6	-0.4	0.7	0.7	-0.5	-0.5	-0.4	-0.8	-0.2
Intermittent access intake day 1-15 change	1.1	1.1	2.1	-0.9	1.5	1.4	-0.9	-0.9	-0.7	-1.1	-0.6
Intermittent access intake escalation	0.7	0.7	2.2	-0.5	1.5	1.4	-0.2	-0.3	-0.0	-0.7	0.3
Intermittent access intake escalation 2	1.1	1.1	3.2	-0.9	1.8	1.7	-0.6	-0.6	-0.4	-1.0	-0.1
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.5	-0.3	1.2	1.2	-0.0	0.0	0.1	-0.6	0.4
Intermitt. access day 15 inactive lever presses	1.1	1.2	3.1	-1.0	1.7	1.7	-0.8	-0.7	-0.5	-1.1	-0.3
Intermitt. access escalation Index	1.1	1.0	1.8	-0.6	0.1	0.2	-1.3	-1.3	-1.2	-0.8	-1.4
Intermittent access day 1 total infusions	0.2	0.2	0.7	0.5	-0.8	-0.7	0.2	0.3	0.3	0.4	0.2
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.1	0.2	0.3	-0.1	-0.0	0.2	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	0.1	-0.0	0.0	-0.4	-0.3	-0.2	-0.2	-0.3
Intermittent access total infusions	0.1	0.1	0.2	0.5	-0.4	-0.3	0.2	0.3	0.5	0.4	0.3
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.0	-0.1	0.0	0.0	0.1	0.1	0.1	0.1
Intermittent access day 15 total locomotion	1.1	1.2	2.3	-1.0	1.4	1.5	-0.9	-1.0	-0.8	-1.3	-0.7
Intermittent access total locomotion	0.4	0.4	0.6	-0.7	0.6	0.7	-0.7	-0.7	-0.6	-0.7	-0.6
Intermittent access standard deviation	0.6	0.7	1.6	-0.7	1.3	1.2	-0.7	-0.6	-0.5	-0.9	-0.3
Left kidney weight	0.1	0.3	0.7	0.2	-0.8	-0.8	-0.2	-0.2	-0.4	0.2	-0.7
Right kidney weight	0.5	1.4	1.8	-1.0	0.8	0.8	-1.3	-1.2	-1.3	-1.3	-1.3
Cocaine induced anxiety	1.6	1.9	2.9	-1.4	0.8	0.8	-1.5	-1.5	-1.6	-1.2	-1.7
Post-drug Anxiety	0.8	0.8	2.2	-0.7	-0.2	-0.2	-1.1	-1.1	-1.1	-0.5	-1.5
Baseline Anxiety	0.1	0.1	0.1	0.1	0.0	0.1	0.3	0.3	0.3	0.1	0.4
Tail length	3.9	11.7	16.0	-3.7	4.0	4.0	-3.1	-3.2	-3.1	-3.6	-2.5
Length with tail	1.3	4.7	5.8	-2.4	2.3	2.3	-2.1	-2.2	-2.1	-2.1	-2.0
Length without tail	0.1	0.2	0.7	0.3	-0.8	-0.8	0.1	0.0	0.1	0.5	-0.3
Times rat made contact with spout	1.4	1.6	2.0	1.3	-1.0	-1.0	1.4	1.4	1.4	1.2	1.4
Lifetime Intake	0.3	0.3	0.7	0.8	-0.8	-0.7	0.3	0.3	0.6	0.6	0.3
Liver weight, left	1.3	2.1	2.8	1.6	-1.3	-1.2	1.6	1.7	1.5	1.3	1.6
Liver weight, right	0.6	1.0	1.4	1.2	-1.0	-1.0	1.0	1.0	0.9	1.1	0.9
Locomotor activity	3.3	5.3	6.7	-2.4	1.9	1.9	-2.4	-2.4	-2.6	-2.3	-2.4
Locomotor testing distance	1.5	2.4	3.2	-1.6	1.3	1.3	-1.6	-1.6	-1.8	-1.6	-1.6
Locomotor testing rearing	0.0	0.0	0.1	0.1	0.1	0.0	0.2	0.2	0.1	0.1	0.3
Locomotion in novel chamber	0.1	0.1	0.1	0.4	-0.2	-0.2	0.3	0.2	0.4	0.2	0.3
Locomotion in novel chamber post-restriction	3.1	3.8	4.5	-2.1	2.1	2.1	-1.8	-1.7	-2.0	-2.0	-1.6
Fecal boli incidents, locomotor time 1	1.3	1.4	2.2	1.1	-0.7	-0.8	1.4	1.5	1.3	1.1	1.5
Change in fecal boli incidents, locomotor task	1.0	0.9	1.9	-0.8	0.3	0.3	-1.1	-1.2	-1.1	-0.8	-1.4
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.1	0.6	-1.1	-1.0	0.3	0.3	0.3	0.7	-0.1
Bouts of movement, locomotor time 1	0.5	0.5	0.7	-0.8	0.8	0.8	-0.7	-0.8	-0.5	-0.7	-0.5
Total resting periods, locomotor time 1	1.0	1.1	1.4	-1.2	1.1	1.1	-1.1	-1.1	-1.0	-1.0	-0.9
Rest time, locomotor task time 1	0.3	0.4	0.6	-0.7	0.4	0.4	-0.7	-0.7	-0.6	-0.4	-0.8
Distance moved, locomotor task time 1	0.3	0.3	0.9	0.6	-0.9	-0.9	0.2	0.2	0.1	0.5	-0.1
Vertical activity count, locomotor time 1	0.6	0.7	1.0	1.0	-0.7	-0.7	0.9	0.8	0.8	0.7	0.9
Time >=10cm from walls, locomotor time 2	1.1	1.1	1.4	1.1	-0.8	-0.9	1.1	1.2	1.1	1.0	1.2
Bouts of movement, locomotor time 2	0.5	0.6	1.3	-0.7	0.2	0.2	-0.9	-1.0	-0.8	-0.4	-1.1
Total resting periods, locomotor time 2	0.6	0.6	1.4	-0.7	0.1	0.1	-0.9	-1.1	-0.9	-0.4	-1.2
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.4	-0.4	-0.4	-0.1	-0.7
Distance moved, locomotor task time 2	0.1	0.1	0.4	0.3	0.2	0.2	0.4	0.4	0.4	0.1	0.7
Vertical activity count, locomotor time 2	1.7	1.8	3.0	1.4	-0.8	-0.8	1.5	1.5	1.5	1.2	1.7
Light reinforcement 1	4.2	7.6	8.6	-2.8	2.9	2.9	-2.6	-2.8	-2.7	-2.9	-2.5
Light reinforcement 2	1.2	1.6	1.9	-1.3	1.4	1.4	-1.2	-1.3	-1.2	-1.3	-1.1
Bone: marrow area	0.2	0.5	1.3	0.8	-1.0	-1.1	0.4	0.4	0.4	0.5	0.1
Bone: maximum diameter	0.9	1.7	3.2	-1.1	0.5	0.4	-1.6	-1.6	-1.6	-1.2	-1.8
Bone: maximum force	2.1	3.6	6.7	2.1	-2.6	-2.6	1.5	1.4	1.6	2.0	0.9
Bone: maximum moment	2.0	3.4	6.4	2.0	-2.5	-2.5	1.4	1.3	1.5	1.9	0.9
Mean time between licks in bursts	1.0	1.4	2.1	-1.2	1.4	1.5	-1.2	-0.9	-1.0	-1.4	-0.7
Mean num. licks in bursts	0.9	1.1	1.5	-1.1	0.9	1.0	-1.0	-1.2	-1.1	-1.0	-1.1
Cd content in liver	0.4	0.4	0.7	0.6	-0.7	-0.8	0.4	0.6	0.7	0.8	0.5
Co content in liver	1.0	1.2	2.1	-1.2	1.4	1.5	-1.0	-0.9	-0.8	-1.1	-0.6
Cu content in liver	0.3	0.4	0.9	0.8	-1.0	-0.9	0.3	0.4	0.3	0.6	-0.0
Fe content in liver	0.5	0.6	0.8	0.8	-0.6	-0.4	0.8	0.8	0.9	0.8	0.9
K content in liver	1.0	1.0	1.8	-0.9	0.5	0.7	-1.2	-1.3	-1.0	-0.8	-1.3
Mg content in liver	0.6	0.6	1.5	-0.7	-0.1	0.0	-0.9	-1.0	-0.8	-0.3	-1.2
Mn content in liver	1.5	1.7	4.6	-1.0	-0.0	-0.0	-1.6	-1.7	-1.5	-0.7	-2.1
Na content in liver	0.1	0.1	0.3	0.3	-0.5	-0.4	0.2	0.2	0.2	0.6	-0.1
Rb content in liver	0.2	0.2	0.5	0.3	-0.7	-0.7	-0.2	-0.4	0.0	0.3	-0.5
Se content in liver	0.0	0.1	0.1	-0.2	-0.0	0.1	-0.3	-0.4	-0.2	-0.0	-0.3
Sr content in liver	0.3	0.3	0.9	-0.3	1.0	0.9	-0.1	-0.1	-0.1	-0.6	0.3
Zn content in liver	1.2	1.3	3.4	-1.1	1.8	1.8	-0.6	-0.5	-0.6	-1.2	0.1
Bone: minimum diameter	0.1	0.2	0.6	0.2	-0.7	-0.8	-0.2	-0.3	-0.2	0.1	-0.5
Time in familiar zone, hab. session 1	4.2	3.9	5.5	-2.2	2.3	2.3	-1.8	-1.8	-1.8	-2.0	-1.4
Time in novel zone, hab. session 1	2.6	2.5	5.0	1.7	-2.2	-2.2	1.2	1.2	1.2	1.7	0.7
Total zone transitions, hab. session 1	0.5	0.7	1.9	-0.8	0.1	0.1	-1.1	-1.0	-1.0	-0.5	-1.4
Total locomotion distance, hab. session 1	2.3	3.3	6.5	-1.7	0.8	0.8	-2.1	-2.2	-2.1	-1.4	-2.5
Locomotion velocity, hab. session 1	2.3	3.2	5.5	-1.8	1.0	1.1	-2.1	-2.1	-2.0	-1.5	-2.3
Time in familiar zone, hab. session 2	4.5	4.7	7.2	-2.3	2.7	2.6	-1.9	-1.9	-1.8	-2.3	-1.3
Time in novel zone, hab. session 2	4.6	4.6	7.5	2.3	-2.7	-2.7	1.8	1.9	1.7	2.3	1.2
Total zone transitions, hab. session 2	0.4	0.5	1.6	0.6	-1.2	-1.2	0.1	0.1	0.0	0.7	-0.4
Total locomotion distance, hab. session 2	0.4	0.5	1.2	-0.6	0.1	0.1	-0.8	-0.8	-0.8	-0.4	-1.1
Locomotion velocity, hab. session 2	0.5	0.6	1.8	-0.7	-0.0	0.0	-0.9	-0.9	-1.0	-0.4	-1.3
Novel to familiar place preference ratio	2.3	2.4	4.8	1.6	-2.1	-2.2	1.1	1.1	1.2	1.8	0.6
Novelty place preference	1.4	1.5	3.1	1.2	-1.7	-1.8	0.8	0.8	0.9	1.4	0.3
Time in novel zone, NPP test	1.9	1.9	3.8	1.5	-1.9	-1.9	1.0	1.0	1.1	1.6	0.5
Total zone transitions, NPP test	0.5	0.7	1.4	0.7	-1.2	-1.1	0.5	0.5	0.6	1.1	0.1
Total locomotion distance, NPP test	0.2	0.2	0.6	0.2	-0.7	-0.8	-0.1	-0.1	-0.1	0.5	-0.5
Locomotion velocity, NPP test	0.1	0.2	0.5	-0.1	-0.4	-0.4	-0.4	-0.4	-0.3	0.2	-0.7
Intraocular pressure	0.2	0.2	0.8	-0.4	0.8	0.9	0.2	0.1	0.1	-0.3	0.5
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.1	-0.0	-0.0	-0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.0	-0.3	-0.3	-0.3	-0.2	-0.2	-0.0	-0.4
Parametrial fat weight	0.0	0.1	0.2	-0.3	0.4	0.4	-0.1	-0.0	0.1	-0.2	0.0
Pavlov. Cond. lever latency	0.2	0.2	0.7	0.3	0.2	0.2	0.5	0.5	0.6	0.2	0.8
Pavlov. Cond. magazine entry latency	1.5	1.9	2.5	-1.4	1.6	1.5	-1.2	-1.2	-1.4	-1.5	-1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	-0.4	-0.4	0.3	0.2	0.1	0.1	0.2
Pavlov. Cond. index score	0.5	0.6	1.0	-0.8	0.5	0.5	-0.9	-0.9	-1.0	-0.7	-1.0
Pavlov. Cond. latency score	0.7	0.9	1.6	-0.9	0.4	0.4	-1.0	-1.1	-1.1	-0.8	-1.3
Pavlov. Cond. lever contacts	0.2	0.2	0.7	-0.2	-0.5	-0.5	-0.4	-0.4	-0.4	0.1	-0.9
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	0.8	-0.8	-0.8	0.7	0.7	0.8	0.8	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.1	0.6	0.6	0.1	0.2	0.2	-0.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.2	-0.9	0.6	0.6	-1.0	-1.0	-1.1	-0.9	-1.1
Pavlov. Cond. response bias	0.6	0.7	0.8	-0.9	0.9	0.9	-0.8	-0.8	-0.9	-0.8	-0.8
Pavlov. Cond. lever latency	1.4	1.9	2.3	1.5	-1.3	-1.4	1.5	1.4	1.3	1.3	1.3
Pavlov. Cond. magazine entry latency	2.5	2.8	3.3	-1.8	1.5	1.6	-1.8	-1.8	-1.7	-1.7	-1.6
Pavlov. Cond. change in total contacts	0.9	1.2	1.5	-1.2	1.1	1.2	-1.1	-1.1	-1.0	-1.1	-0.9
Pavlov. Cond. index score	2.2	2.8	3.2	-1.8	1.6	1.7	-1.7	-1.7	-1.6	-1.7	-1.4
Pavlov. Cond. latency score	2.2	2.7	3.2	-1.8	1.5	1.6	-1.7	-1.7	-1.6	-1.6	-1.6
Pavlov. Cond. lever contacts	1.2	1.7	2.1	-1.4	1.4	1.5	-1.3	-1.3	-1.1	-1.3	-1.0
Pavlov. Cond. magazine entry number	2.5	3.0	3.3	1.8	-1.6	-1.6	1.8	1.8	1.7	1.8	1.6
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.1	1.2	-0.9	-0.9	1.3	1.3	1.5	1.2	1.4
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.1	3.5	-1.9	1.7	1.8	-1.8	-1.8	-1.7	-1.8	-1.6
Pavlov. Cond. response bias	2.1	2.9	3.6	-1.8	1.8	1.9	-1.7	-1.7	-1.5	-1.8	-1.3
Time in closed arm before self-admin	0.3	0.3	1.0	0.3	-1.0	-1.0	-0.1	-0.0	-0.1	0.4	-0.4
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1	0.2	0.3	0.0	0.2
Time in open arm before self-admin	0.9	1.0	2.0	-0.9	1.4	1.4	-0.9	-0.8	-0.7	-1.1	-0.5
Time in open arm after self-admin	1.4	1.6	1.9	1.2	-1.1	-1.1	1.3	1.3	1.3	1.4	1.3
Bone: periosteal estimation	0.4	0.9	2.8	1.0	-1.5	-1.7	0.3	0.2	0.3	0.7	-0.2
Bone: periosteal perimeter	0.3	0.6	1.5	-0.3	-0.3	-0.4	-0.9	-1.0	-0.9	-0.5	-1.2
Bone: post-yield work	0.3	0.4	0.5	0.7	-0.6	-0.7	0.5	0.5	0.7	0.6	0.5
Progressive ratio test 1 active lever presses	0.9	0.9	1.2	1.1	-1.1	-0.9	0.8	0.9	1.1	1.0	0.8
Progressive ratio test 1 breakpoint	0.9	1.0	1.4	1.1	-1.2	-1.0	0.8	0.9	1.1	1.0	0.8
Progressive ratio test 1 inactive lever presses	0.5	0.6	0.9	-0.5	0.8	0.9	-0.9	-0.8	-0.6	-1.0	-0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.5	-0.5	-0.3	0.1	0.2	0.5	0.3	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.0	-0.2	-0.1	-0.5	-0.4	-0.2	-0.2	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.4	-0.3	0.0	-0.0	-0.3
Incentive Sensitization - Responses	0.4	0.4	0.5	-0.5	0.6	0.6	-0.7	-0.7	-0.5	-0.6	-0.5
Incentive Sensitization - Breakpoint	0.5	0.6	0.8	-0.7	0.7	0.7	-0.9	-0.9	-0.7	-0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.5	0.6	0.6	-0.4	-0.4	-0.4	-0.5	-0.3
Progressive ratio	0.9	1.0	1.3	1.1	-0.9	-0.9	1.1	1.0	1.1	1.0	1.1
Food seeking constrained by brief footshock	0.9	1.1	1.5	-1.2	1.1	1.2	-0.9	-0.9	-1.0	-1.0	-0.8
Seeking ratio, punishment vs. effort	1.5	1.8	2.4	-1.5	1.4	1.4	-1.2	-1.2	-1.4	-1.3	-1.2
Retroperitoneal fat weight	2.5	8.1	9.2	3.0	-2.7	-2.7	2.9	2.9	3.0	2.9	2.7
Reaction time number correct	1.5	2.2	3.2	1.4	-0.9	-1.0	1.8	1.6	1.6	1.4	1.7
Reaction time mean minus median	1.2	1.7	1.9	-1.4	1.2	1.2	-1.4	-1.3	-1.3	-1.3	-1.2
Reaction time mean minus median AUC	1.7	2.3	4.0	-1.5	0.7	0.6	-1.8	-1.7	-1.8	-1.3	-2.0
Reaction time num false alarms	0.6	0.9	1.3	1.0	-0.9	-0.8	0.9	0.8	1.1	1.1	0.9
Reaction time num false alarms AUC	0.8	1.2	1.9	1.1	-0.8	-0.8	1.1	1.0	1.4	1.2	1.2
Reaction time trials correct on left	1.5	2.2	3.2	1.4	-0.9	-1.0	1.8	1.6	1.6	1.4	1.7
Reaction time trials on left	1.4	2.0	2.9	1.4	-0.9	-1.0	1.7	1.6	1.6	1.4	1.7
Reaction time mean	1.1	1.6	2.4	-1.3	0.7	0.7	-1.5	-1.4	-1.5	-1.1	-1.6
Reaction time mean AUC	0.6	0.8	1.5	-0.9	0.3	0.3	-1.1	-1.0	-1.1	-0.7	-1.2
Median of all reaction times	0.6	0.8	1.4	-0.9	0.4	0.4	-1.0	-1.0	-1.1	-0.7	-1.2
Reaction time omissions	0.1	0.1	0.2	-0.2	0.1	0.0	-0.4	-0.4	-0.4	-0.3	-0.5
Reaction time false alarm rate	0.1	0.1	0.3	0.4	-0.5	-0.4	0.1	0.1	0.4	0.5	0.1
Reaction time premature initiation rate	1.0	1.3	3.0	-1.2	1.7	1.6	-0.8	-0.7	-0.8	-1.2	-0.4
Reaction time premature initiations	0.4	0.5	1.7	-0.5	1.3	1.2	0.1	0.2	0.1	-0.5	0.6
Std. dev. reaction times	0.9	1.3	1.8	-1.2	0.7	0.7	-1.4	-1.3	-1.2	-1.0	-1.3
Reaction time trials completed	1.4	2.0	2.9	1.4	-0.9	-1.0	1.7	1.6	1.6	1.4	1.7
Reaction time trials AUC	1.7	2.4	3.6	1.5	-0.9	-1.0	1.9	1.8	1.7	1.5	1.9
Run reversals in cocaine runway, females	1.9	1.8	2.2	-1.4	1.0	1.0	-1.4	-1.4	-1.5	-1.3	-1.4
Run reversals in cocaine runway, males	3.2	3.1	3.8	-1.8	1.6	1.6	-1.9	-1.6	-1.9	-1.9	-1.8
Latency to leave start box in cocaine runway	0.4	0.4	1.0	0.2	-1.0	-1.0	-0.4	-0.4	-0.2	0.4	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.6	1.6	0.2	-1.3	-1.3	-0.4	-0.4	-0.3	0.5	-1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.1	0.2	0.2	0.3	0.2	0.6	0.2	0.6
Std. dev. time between licks in bursts	1.3	1.5	2.3	-1.1	0.8	0.7	-1.5	-1.3	-1.4	-1.2	-1.5
Total sessions with >9 infusions	0.4	0.5	1.2	-0.1	-0.3	-0.2	-1.0	-0.9	-0.7	-0.5	-1.1
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.2	0.3	0.4	-0.4	-0.3	-0.3	-0.5	-0.3
Short access day 10 total inactive lever presses	0.2	0.3	0.9	-0.2	0.9	0.9	0.0	-0.0	0.1	-0.5	0.3
Short access day 1 total infusions	0.2	0.3	0.6	0.3	-0.7	-0.6	-0.6	-0.5	-0.3	-0.0	-0.8
Short access day 10 total infusions	0.2	0.2	0.5	0.6	-0.7	-0.5	0.2	0.2	0.4	0.3	0.2
Short access total infusions	0.5	0.5	1.4	0.9	-1.2	-1.1	0.1	0.2	0.4	0.6	-0.1
Short access day 1 locomotion	0.6	0.6	1.1	-0.6	0.2	0.5	-1.0	-1.0	-0.8	-0.8	-1.0
Short access day 10 total locomotion	2.8	3.2	5.8	-1.7	2.3	2.4	-1.5	-1.5	-1.4	-2.0	-1.0
Short access total locomotion	0.7	0.8	1.0	-0.8	0.7	0.9	-1.0	-1.0	-0.9	-0.9	-0.9
One hour access (0.3 mA shock)	0.3	0.3	0.4	0.6	-0.6	-0.5	0.6	0.5	0.7	0.6	0.5
Compulsive drug intake	0.4	0.4	0.7	0.6	-0.8	-0.7	0.7	0.6	0.6	0.7	0.5
One hour access (shock baseline)	0.1	0.1	0.2	0.1	0.4	0.4	0.0	0.1	0.2	-0.1	0.3
Social response proportion	0.6	0.6	0.9	-0.9	0.6	0.6	-0.7	-0.8	-0.9	-0.7	-0.9
Social responses	8.7	11.1	12.6	-3.6	2.9	3.0	-3.4	-3.5	-3.5	-3.3	-3.3
Social time	1.4	1.9	2.5	1.5	-1.2	-1.3	1.6	1.5	1.2	1.2	1.4
Soleus weight	6.8	19.8	22.2	4.7	-4.6	-4.7	4.4	4.3	4.4	4.6	3.8
Bone: stiffness	3.6	5.7	8.5	2.6	-2.9	-2.9	2.0	2.0	2.2	2.5	1.5
Tibialis anterior weight	1.4	4.8	5.6	2.3	-2.4	-2.3	2.1	2.0	2.2	2.4	1.8
Time to tail flick, vehicle, before self-admin	3.6	3.6	5.2	-1.7	1.3	1.2	-2.1	-2.1	-2.2	-2.1	-2.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	-0.3	0.6	0.7	-0.0	0.0	0.0	-0.2	0.3
Time to tail flick, test, before self-admin	1.6	1.6	2.7	-1.2	0.5	0.6	-1.6	-1.4	-1.5	-1.1	-1.6
Time to tail flick, test, after self-admin	0.4	0.4	1.0	-0.4	-0.0	-0.1	-0.8	-0.7	-0.7	-0.4	-1.0
Delta time to tail flick, vehicle, before/after SA	3.2	3.1	4.7	1.5	-1.1	-1.0	2.0	2.0	2.0	1.9	2.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.0	0.4	0.3	0.4	0.3	0.3	0.1	0.5
Tibia length	0.7	1.9	2.8	-1.6	1.6	1.7	-1.3	-1.3	-1.1	-1.2	-1.0
Ambulatory time before self-admin	0.2	0.2	0.4	-0.5	0.6	0.5	-0.4	-0.5	-0.4	-0.5	-0.4
Ambulatory time after self-admin	0.1	0.1	0.2	-0.3	0.2	0.2	-0.3	-0.4	-0.3	-0.3	-0.4
Bone: tissue strength	3.3	3.2	4.4	2.0	-2.1	-2.1	1.6	1.6	1.7	1.8	1.3
Total heroin consumption	2.1	2.4	2.9	-1.7	1.5	1.4	-1.6	-1.6	-1.6	-1.5	-1.6
Bone: trabecular number	1.0	1.6	3.6	-1.2	0.2	0.3	-1.6	-1.6	-1.4	-0.9	-1.9
Bone: trabecular spacing	1.0	1.3	3.8	0.7	0.5	0.4	1.4	1.4	1.3	0.4	1.9
Bone: trabecular thickness	1.3	1.5	4.3	-0.3	-1.2	-1.2	-1.3	-1.3	-1.2	-0.1	-2.1
Bone: trabecular tissue density	5.7	8.0	9.1	3.0	-2.6	-2.6	2.9	2.9	3.0	2.8	2.9
Water consumed over 24 hours	0.4	0.5	1.2	0.8	-1.1	-1.1	0.4	0.3	0.4	0.8	-0.0
Number of responses in last shaping day	2.3	2.3	3.0	-1.4	1.7	1.7	-1.6	-1.5	-1.3	-1.7	-1.2