Hub : Genes

Tmem184b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr7_112807683_112810176 0.05 0.03 1.7e-04 0.01 0.02 0.02 0.01 4.1e-02 1.0e-03 9.6e-04 2.1e-02
2 pVTA gene expression Tmem184b 0.05 0.03 3.6e-04 0.02 0.04 0.02 0.03 7.2e-03 1.7e-04 8.8e-03 1.6e-03
3 BLA gene expression Tmem184b 0.31 0.11 1.5e-11 0.19 0.17 0.16 0.19 1.7e-10 3.7e-09 5.8e-09 3.1e-10
4 PL gene expression Tmem184b 0.18 0.07 0.0e+00 0.21 0.17 0.18 0.19 4.4e-22 1.7e-18 3.5e-19 1.6e-20
5 IC gene expression Tmem184b 0.34 0.12 2.1e-12 0.33 0.24 0.27 0.29 1.3e-14 1.1e-10 6.5e-12 9.1e-13
6 NAcc gene expression Tmem184b 0.36 0.06 0.0e+00 0.43 0.43 0.45 0.45 1.0e-70 1.0e-71 2.5e-76 1.8e-76
7 Adipose mRNA stability Tmem184b 0.04 0.02 7.1e-05 0.03 0.03 0.02 0.02 3.1e-04 1.5e-04 8.8e-04 4.0e-03
8 Adipose gene expression Tmem184b 0.44 0.11 0.0e+00 0.35 0.43 0.43 0.43 2.2e-40 1.1e-51 6.0e-52 2.7e-52
9 Brain gene expression Tmem184b 0.69 0.11 0.0e+00 0.33 0.34 0.36 0.37 1.8e-31 4.0e-33 4.2e-35 2.1e-36
10 OFC gene expression Tmem184b 0.49 0.17 6.8e-06 0.08 0.19 0.25 0.27 7.2e-03 3.3e-05 1.1e-06 3.4e-07
11 NAcc mRNA stability Tmem184b 0.03 0.02 7.7e-05 0.01 0.02 0.01 0.01 2.8e-02 1.1e-04 5.4e-03 7.6e-03
12 PL mRNA stability Tmem184b 0.05 0.03 1.1e-04 0.02 0.04 0.02 0.03 9.8e-04 5.4e-05 1.1e-03 6.1e-04
13 BLA mRNA stability Tmem184b 0.1 0.05 4.8e-04 0.08 0.05 0.06 0.07 3.3e-05 8.0e-04 2.9e-04 1.1e-04
14 Brain mRNA stability Tmem184b 0.12 0.08 3.3e-05 0.08 0.05 0.07 0.07 7.6e-08 9.1e-06 5.0e-07 3.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.00.1-0.1-0.10.10.1-0.3-0.20.0-0.2-0.2-0.1-0.1-0.10.0-0.3
Area under the delay curve2.12.55.6-2.0-2.4-1.8-1.6-1.7-1.8-1.9-1.7-1.5-1.40.70.70.70.8
BMI with tail0.10.52.41.61.20.00.10.30.71.20.60.50.3-0.20.1-0.00.2
BMI without tail0.41.33.61.41.90.20.20.41.11.70.91.01.2-1.3-1.1-1.2-0.9
Body weight1.46.012.62.73.52.52.42.42.93.42.72.82.6-0.7-0.6-1.5-1.2
Weight adjusted by age0.50.71.61.31.11.01.01.11.20.80.90.90.50.20.30.40.2
Bone surface0.20.30.7-0.3-0.6-0.0-0.1-0.5-0.6-0.5-0.7-0.7-0.80.60.40.80.7
Bone volume0.10.10.4-0.2-0.3-0.0-0.1-0.6-0.5-0.3-0.6-0.6-0.5-0.1-0.20.2-0.0
Breakpoint value in progressive ratio session0.20.30.9-0.5-0.6-0.6-0.9-0.6-0.7-0.3-0.6-0.6-0.50.20.10.30.1
Number of licking bursts0.61.01.9-0.8-0.7-1.3-1.4-1.4-1.1-0.8-1.1-1.3-0.8-0.8-0.9-0.20.2
Context. condit. distance diff. score4.04.99.73.12.62.72.52.32.52.02.32.52.6-0.4-0.1-1.6-1.2
Locomotion velocity, session 10.80.92.10.10.11.11.31.41.20.30.81.20.51.31.00.70.6
Locomotion distance, session 12.83.56.2-1.8-2.5-1.9-1.8-1.6-1.9-2.5-2.2-2.0-2.20.90.71.71.6
Locomotion velocity, session 21.51.86.10.2-1.10.30.50.3-0.2-0.9-0.3-0.6-1.42.22.12.52.3
Locomotion distance, session 23.14.39.1-3.0-2.9-1.8-1.7-1.8-2.2-2.5-2.2-2.1-2.41.10.71.91.4
Locomotion velocity, session 30.70.84.42.11.30.60.71.01.10.30.80.80.8-0.3-0.0-0.1-0.4
Locomotion distance, session 31.31.42.80.3-0.4-1.7-1.7-1.5-1.2-1.3-1.5-1.4-0.8-1.4-1.2-0.2-0.3
Stereotopy head waving bouts, day 30.81.02.40.10.81.51.51.41.21.21.21.10.70.80.60.20.1
Stereotopy head waving duration, day 33.34.07.81.51.72.62.72.82.52.22.42.21.41.61.40.60.6
Locomotion velocity, session 70.40.41.11.11.00.30.50.50.81.00.70.70.5-0.2-0.2-0.2-0.2
Locomotion distance, session 70.91.22.4-0.10.90.80.90.91.11.21.01.41.6-0.6-0.9-1.5-1.3
Stereotopy head waving bouts, day 72.63.010.53.21.51.82.02.21.91.21.71.40.71.41.71.11.0
Stereotopy head waving duration, day 72.22.610.33.21.21.41.51.91.60.81.61.10.41.62.11.31.3
Locomotion velocity, session 81.82.24.11.61.01.81.72.01.91.01.61.81.01.61.40.50.8
Locomotion distance, session 80.50.71.81.30.51.21.21.11.00.20.81.00.80.60.80.0-0.1
Degree of sensitization distance5.55.610.40.41.92.93.12.92.82.93.03.22.80.70.4-1.5-1.2
Degree of sensitization stereotypy2.32.59.83.10.91.31.51.81.40.51.20.90.11.82.11.61.4
Conditioned locomotion0.70.81.71.01.21.11.11.11.11.30.90.80.60.20.10.40.1
Cocaine response after cond. corrected0.50.62.2-0.1-0.20.50.60.40.30.30.10.1-0.61.51.21.51.3
Cocaine response after cond. not corrected0.50.61.9-0.1-0.40.10.10.0-0.1-0.1-0.3-0.3-0.91.31.21.41.4
Cocaine response before conditioning0.60.71.7-0.1-0.6-1.2-1.3-1.1-1.1-0.9-0.9-1.0-0.6-0.8-0.6-0.3-0.1
Saline control response0.30.30.80.70.70.80.90.60.50.20.50.50.6-0.4-0.3-0.4-0.7
Bone: connectivity density0.20.20.60.30.60.80.70.40.60.60.50.50.4-0.1-0.3-0.2-0.4
Bone: cortical apparent density0.70.94.70.60.8-0.5-0.4-0.6-0.20.0-0.4-0.40.2-2.2-1.9-0.9-1.3
Bone: cortical area0.30.41.6-0.40.00.70.70.10.00.5-0.1-0.3-0.70.90.61.21.3
Bone: cortical porosity0.40.51.9-0.1-0.30.70.60.20.10.1-0.00.1-0.31.41.20.71.3
Bone: cortical porosity1.01.14.30.20.01.21.20.80.60.50.50.6-0.12.11.71.01.7
Bone: cortical thickness1.01.73.5-1.9-1.2-1.1-1.1-1.8-1.7-0.9-1.7-1.8-1.6-0.3-0.60.60.7
Bone: cortical thickness1.72.04.9-2.2-1.6-1.2-1.3-1.7-1.7-1.2-2.0-1.7-1.50.1-0.30.61.0
Bone: cortical tissue density0.60.94.30.60.8-0.5-0.4-0.5-0.10.1-0.3-0.30.3-2.1-1.8-0.9-1.3
Condit. Reinf. active minus inactive responses0.60.62.2-0.60.4-0.3-0.2-0.4-0.20.1-0.3-0.10.5-1.4-1.5-1.3-1.3
Condit. Reinf. active-inactive response ratio0.50.51.50.30.80.20.30.10.20.30.20.20.9-1.2-1.2-1.2-1.1
Condit. Reinf. active responses1.31.75.4-0.60.5-0.7-0.4-0.8-0.40.1-0.3-0.10.9-2.3-2.2-2.2-2.3
Condit. Reinf. inactive responses1.51.86.7-0.50.4-1.0-0.8-0.8-0.30.0-0.00.21.0-2.4-2.0-2.3-2.6
Incentive salience index mean0.91.14.1-0.70.6-0.6-0.4-0.6-0.20.4-0.2-0.10.6-1.9-2.0-1.5-1.5
Condit. Reinf. lever presses0.91.35.2-0.60.8-1.0-0.8-0.8-0.10.7-0.2-0.10.5-2.2-2.3-1.5-1.4
Condit. Reinf. active minus inactive responses0.20.31.8-1.3-0.9-0.3-0.4-0.4-0.3-0.5-0.40.10.00.80.6-0.20.1
Condit. Reinf. active-inactive response ratio0.10.20.7-0.7-0.30.30.30.20.20.20.10.40.20.90.60.10.0
Condit. Reinf. active responses0.30.51.9-1.1-1.0-0.1-0.2-0.1-0.2-0.6-0.20.1-0.41.41.10.50.7
Condit. Reinf. inactive responses0.40.61.3-0.7-1.0-0.5-0.6-0.5-0.6-0.9-0.6-0.6-0.90.70.50.81.1
Condit. Reinf. lever presses0.20.30.8-0.9-0.6-0.8-0.8-0.5-0.4-0.4-0.0-0.00.2-0.2-0.2-0.8-0.7
Condit. Reinf. lever reinforcers received0.30.41.8-1.0-0.80.20.10.10.1-0.30.10.4-0.11.41.10.40.5
Conditioned reinforcement - actives1.72.85.6-2.4-2.1-1.9-1.7-1.8-2.0-2.0-2.1-1.9-1.70.40.10.90.8
Conditioned reinforcement - inactives2.33.410.4-3.2-1.9-2.4-2.2-2.3-2.1-1.5-2.0-1.8-1.3-0.6-1.1-0.2-0.1
Conditioned locomotion1.51.95.6-2.4-1.8-0.8-1.0-1.1-1.4-1.3-1.3-1.3-1.51.41.01.31.0
Patch foraging indifference point 0 sec0.50.81.9-0.41.10.50.20.50.71.10.90.70.9-1.1-1.3-1.0-1.4
Patch foraging indifference point AUC0.81.13.0-1.7-1.0-1.3-1.4-1.3-1.1-1.1-1.3-1.1-0.7-0.6-0.8-0.1-0.1
Delay disc. indifference point, 0s delay0.10.10.7-0.8-0.4-0.1-0.2-0.4-0.40.0-0.1-0.2-0.30.50.40.20.3
Delay disc. indifference point, 16s delay2.22.45.6-2.0-2.4-1.6-1.2-1.5-1.7-1.9-1.7-1.6-1.50.80.80.91.0
Delay disc. indifference point, 2s delay7.38.115.6-2.5-4.0-2.7-2.7-2.7-3.3-3.4-3.1-3.0-3.11.92.02.32.4
Delay disc. indifference point, 24s delay0.10.10.4-0.30.0-0.20.2-0.00.1-0.0-0.3-0.4-0.4-0.1-0.50.40.6
Delay disc. indifference point, 4s delay1.31.33.5-1.4-1.9-1.0-1.1-0.9-1.0-1.4-1.0-0.8-1.11.21.30.60.9
Delay disc. indifference point, 8s delay1.11.33.4-1.9-1.3-1.5-1.5-1.5-1.2-1.0-1.2-0.9-0.4-0.7-0.7-0.5-0.6
Indifference point function ln k0.91.65.12.31.41.51.71.41.41.21.51.30.80.40.60.2-0.0
Indifference point function log k0.91.65.12.31.41.51.71.41.41.21.51.30.80.40.60.2-0.0
Patch foraging total patch changes 0 sec0.30.61.9-0.70.7-0.0-0.4-0.00.20.60.50.20.6-1.2-1.4-1.0-1.3
Patch foraging total patch changes 12 sec0.10.21.4-1.2-0.2-0.1-0.5-0.2-0.1-0.1-0.2-0.3-0.40.1-0.40.30.2
Patch foraging total patch changes 18 sec0.30.53.3-1.8-0.1-0.5-0.8-0.6-0.30.2-0.2-0.4-0.2-0.5-1.1-0.3-0.1
Patch foraging total patch changes 24 sec0.71.33.7-1.5-0.1-1.1-1.4-1.1-0.7-0.3-0.6-0.60.1-1.7-1.9-1.3-1.2
Patch foraging total patch changes 6 sec0.30.43.2-1.8-0.2-0.5-0.7-0.5-0.3-0.0-0.4-0.4-0.1-0.6-0.9-0.3-0.3
Patch foraging time to switch 0 sec0.51.14.6-0.0-0.90.40.40.3-0.0-0.30.00.1-0.72.02.11.31.8
Patch foraging water rate 0 sec1.22.55.90.22.10.50.30.61.11.81.11.11.7-2.2-2.4-2.0-2.4
Patch foraging water rate 12 sec0.20.52.10.30.8-0.4-0.2-0.5-0.10.50.0-0.30.1-1.4-1.5-0.5-0.6
Patch foraging water rate 18 sec0.81.23.00.41.70.60.70.61.01.30.90.61.1-1.5-1.7-0.9-1.1
Patch foraging water rate 24 sec2.02.95.51.82.31.81.71.82.02.12.01.81.9-0.7-0.7-1.0-1.0
Patch foraging water rate 6 sec1.11.66.60.41.4-0.4-0.3-0.50.00.80.1-0.10.7-2.6-2.6-1.6-1.8
Seeking ratio, delayed vs. immediate footshock0.20.20.40.5-0.4-0.4-0.6-0.1-0.5-0.5-0.4-0.4-0.40.30.60.40.4
Distance traveled before self-admin0.81.03.1-1.3-1.7-0.5-0.2-0.3-0.9-1.0-0.6-0.8-0.91.31.41.01.1
Distance traveled after self-admin0.30.41.1-0.80.60.70.80.70.81.10.60.70.40.0-0.4-0.30.0
Extensor digitorum longus weight0.62.54.6-1.2-2.0-1.7-1.7-2.0-2.2-1.7-2.1-1.9-1.80.20.70.61.0
Bone: elastic displacement0.80.91.81.00.91.01.21.41.31.01.21.10.70.60.70.10.3
Bone: elastic work1.92.54.60.80.92.02.12.01.71.61.51.40.42.11.91.31.3
Bone: endosteal estimation1.02.34.31.00.91.91.92.11.71.41.61.50.62.01.61.21.1
Bone: endosteal perimeter1.12.44.31.51.01.91.91.81.51.31.21.0-0.02.11.71.81.9
Epididymis fat weight1.13.96.32.42.52.22.22.32.32.32.22.32.20.0-0.0-1.1-1.1
Delta time in closed arm before/after self-admin1.11.03.2-1.8-1.1-1.0-1.2-1.2-1.2-1.0-1.3-1.1-0.9-0.0-0.10.20.2
Delta time in open arm before/after self-admin0.20.20.40.7-0.00.40.60.60.50.00.60.30.30.50.6-0.10.1
Diff in mean of infusions in LGA sessions0.20.30.60.40.60.50.50.70.70.70.60.60.7-0.2-0.5-0.4-0.5
Delay discount exponential model param2.22.55.42.02.31.81.71.71.81.91.71.51.5-0.7-0.7-0.7-0.8
Extinction: sum of active levers before priming1.51.73.3-0.6-1.7-0.8-0.8-0.9-1.1-1.2-1.1-1.2-1.61.61.41.81.6
Active lever presses in extinction session 60.20.20.70.4-0.4-0.00.1-0.1-0.2-0.2-0.2-0.4-0.50.80.70.80.7
Bone: final force0.50.92.9-0.4-0.10.80.80.40.30.60.2-0.0-0.71.71.31.61.6
Bone: final moment0.60.93.0-0.40.11.01.00.70.60.80.40.3-0.51.71.21.51.4
Food consumed during 24 hour testing period0.30.41.4-0.7-0.4-0.1-0.1-0.2-0.4-0.2-0.4-0.5-0.90.80.41.21.0
Glucose0.40.72.2-0.60.8-0.0-0.0-0.30.21.00.30.40.8-1.2-1.4-1.5-0.9
Heart weight3.04.79.02.02.33.03.02.72.72.72.52.31.51.10.70.30.4
Delay discount hyperbolic model param2.83.16.92.12.62.01.91.92.02.21.91.71.6-0.8-0.9-0.8-0.9
Intermittent access intake day 1-15 change0.10.30.8-0.1-0.2-0.7-0.7-0.9-0.7-0.5-0.6-0.6-0.5-0.6-0.5-0.2-0.2
Intermittent access intake escalation0.20.30.8-0.0-0.1-0.7-0.7-0.9-0.7-0.6-0.6-0.6-0.4-0.7-0.6-0.3-0.3
Intermittent access intake escalation 20.30.31.2-0.00.2-0.6-0.3-0.5-0.4-0.1-0.3-0.30.1-1.1-1.0-0.8-0.8
Intermitt. access day 1 inactive lever presses0.41.42.7-0.41.10.91.31.31.51.71.51.51.5-0.2-0.6-1.0-0.8
Intermitt. access day 15 inactive lever presses0.10.20.7-0.80.0-0.10.40.10.20.40.20.40.6-0.4-0.7-0.7-0.5
Intermitt. access escalation Index1.11.64.0-0.3-1.0-1.7-2.0-1.7-1.5-1.3-1.4-1.5-1.3-0.6-0.50.20.3
Intermittent access day 1 total infusions1.82.86.0-2.5-2.4-1.2-1.2-1.1-1.5-1.9-1.5-1.5-1.81.71.21.71.7
Intermittent access day 15 total infusions1.62.34.1-1.9-2.0-1.4-1.5-1.6-1.8-1.9-1.7-1.7-1.80.70.51.11.1
Intermittent access terminal intake (last 3 days)1.41.93.7-1.6-1.9-1.2-1.1-1.2-1.4-1.8-1.4-1.4-1.50.90.71.21.2
Intermittent access total infusions3.13.67.7-2.8-2.7-1.6-1.6-1.6-1.9-2.1-1.9-1.8-2.11.61.21.71.7
Intermittent access day 1 locomotion0.91.24.4-2.1-1.5-1.0-1.1-1.1-1.2-1.0-1.0-1.0-1.00.60.30.60.5
Intermittent access day 15 total locomotion0.30.52.6-1.6-0.9-0.2-0.5-0.8-0.8-0.6-0.7-0.7-0.70.2-0.10.30.2
Intermittent access total locomotion0.40.54.1-2.0-0.6-0.5-0.6-0.7-0.6-0.2-0.5-0.4-0.3-0.1-0.5-0.2-0.3
Intermittent access standard deviation0.20.43.3-1.8-0.40.40.70.20.00.40.10.1-0.00.80.40.20.2
Left kidney weight3.918.238.24.13.76.25.95.75.04.14.54.63.13.63.11.01.1
Right kidney weight5.123.145.54.24.86.76.66.35.95.35.55.64.22.82.2-0.10.1
Cocaine induced anxiety0.20.20.80.70.40.80.90.50.20.30.20.30.20.40.50.10.2
Post-drug Anxiety1.01.02.11.51.40.91.00.91.01.30.81.01.2-0.6-0.3-1.0-0.9
Baseline Anxiety0.20.20.5-0.20.0-0.6-0.7-0.5-0.10.1-0.3-0.20.1-0.7-0.7-0.5-0.4
Tail length0.93.46.11.02.51.31.21.01.61.91.41.62.2-2.2-2.1-2.4-2.3
Length with tail1.67.112.42.43.53.23.12.83.03.12.72.93.1-1.1-1.1-2.0-1.9
Length without tail2.06.412.72.12.73.63.53.33.02.93.02.82.41.00.7-0.4-0.4
Times rat made contact with spout1.61.98.6-1.10.5-1.2-1.0-1.3-0.80.0-1.1-1.0-0.0-2.5-2.9-1.3-1.2
Lifetime Intake3.23.99.4-3.1-2.8-1.6-1.5-1.5-1.9-2.1-1.9-1.8-2.21.81.21.81.8
Liver weight, left0.10.11.11.00.4-0.10.20.20.2-0.2-0.00.20.5-0.10.1-0.50.0
Liver weight, right1.72.910.63.32.61.21.21.61.71.41.51.62.0-1.1-0.7-1.5-1.2
Locomotor activity0.40.61.40.91.01.21.10.90.90.90.70.70.40.40.20.30.3
Locomotor testing distance0.30.51.2-0.40.0-0.7-0.7-0.9-0.8-0.3-0.9-0.9-0.6-1.0-1.1-0.2-0.2
Locomotor testing rearing0.10.20.60.20.20.50.60.20.00.1-0.1-0.2-0.40.50.20.80.6
Locomotion in novel chamber0.91.22.40.1-0.5-1.5-1.4-1.5-1.2-1.1-1.2-1.3-0.6-1.5-0.9-0.6-0.6
Locomotion in novel chamber post-restriction1.62.64.4-1.0-1.7-2.0-2.1-1.9-2.1-1.9-2.0-2.1-1.7-0.4-0.20.60.4
Fecal boli incidents, locomotor time 10.20.21.7-1.30.30.10.2-0.00.40.70.30.30.0-0.1-0.6-0.2-0.0
Change in fecal boli incidents, locomotor task0.40.42.11.41.10.60.40.50.60.40.10.20.2-0.5-0.50.10.1
Time >=10cm from walls, locomotor time 10.60.61.30.10.71.21.10.90.91.00.80.70.30.80.50.40.5
Bouts of movement, locomotor time 10.00.10.20.30.50.10.1-0.20.10.30.0-0.0-0.1-0.2-0.4-0.2-0.3
Total resting periods, locomotor time 10.00.00.30.00.40.20.2-0.10.20.50.20.0-0.10.1-0.2-0.1-0.1
Rest time, locomotor task time 10.50.61.4-0.00.90.80.70.70.91.20.90.80.8-0.3-0.6-0.8-0.5
Distance moved, locomotor task time 10.10.21.61.30.30.40.40.50.3-0.10.20.30.30.20.50.30.3
Vertical activity count, locomotor time 10.61.53.10.51.60.60.30.50.81.30.81.01.6-1.8-1.7-1.6-1.6
Time >=10cm from walls, locomotor time 20.71.03.11.01.71.00.90.91.31.81.00.80.5-0.4-0.7-0.10.2
Bouts of movement, locomotor time 22.03.25.5-0.6-1.9-2.0-2.1-2.4-2.3-1.9-2.0-2.1-2.30.50.61.31.3
Total resting periods, locomotor time 22.23.96.2-1.1-2.2-2.1-2.2-2.4-2.4-2.2-2.2-2.2-2.50.80.91.51.5
Rest time, locomotor task time 20.10.11.0-1.0-0.3-0.2-0.3-0.1-0.1-0.0-0.3-0.2-0.20.1-0.1-0.10.3
Distance moved, locomotor task time 20.80.92.81.71.31.01.11.01.01.01.01.01.0-0.3-0.1-0.3-0.5
Vertical activity count, locomotor time 20.91.23.10.71.80.70.50.61.11.61.01.01.1-1.3-1.4-1.0-1.0
Light reinforcement 10.10.10.5-0.1-0.3-0.2-0.2-0.2-0.2-0.2-0.3-0.3-0.60.50.40.70.4
Light reinforcement 20.30.41.20.9-0.20.00.1-0.1-0.3-0.4-0.3-0.6-0.80.71.01.10.7
Bone: marrow area1.12.44.71.01.01.91.92.21.81.41.71.50.72.01.61.11.1
Bone: maximum diameter1.32.54.80.81.02.22.21.81.51.61.31.10.22.11.61.61.7
Bone: maximum force0.61.13.5-0.8-0.11.01.00.50.30.70.10.0-0.71.91.31.71.7
Bone: maximum moment0.71.23.9-0.60.01.31.20.80.60.90.40.3-0.52.01.31.61.6
Mean time between licks in bursts0.61.34.30.2-1.3-0.5-0.6-0.3-0.6-1.0-0.6-0.7-1.21.62.11.51.9
Mean num. licks in bursts0.30.51.20.21.00.60.80.50.60.70.40.50.8-0.9-1.1-0.7-1.1
Cd content in liver0.30.30.70.4-0.2-0.3-0.4-0.6-0.6-0.7-0.8-0.8-0.70.10.10.60.7
Co content in liver0.80.91.9-1.3-0.9-1.0-1.0-1.3-1.1-0.6-1.2-1.4-1.0-0.2-0.40.30.7
Cu content in liver2.32.75.3-1.5-1.4-2.3-2.2-2.2-2.0-1.4-1.9-2.0-1.2-1.4-1.2-0.3-0.1
Fe content in liver3.54.38.21.91.92.92.82.82.52.22.42.31.41.61.40.50.4
K content in liver0.00.00.2-0.2-0.1-0.00.1-0.3-0.1-0.1-0.2-0.2-0.1-0.4-0.4-0.1-0.2
Mg content in liver0.00.00.2-0.30.00.10.2-0.3-0.10.0-0.2-0.2-0.2-0.3-0.50.0-0.1
Mn content in liver0.40.50.9-0.2-0.6-0.7-0.7-0.9-0.9-1.0-0.9-0.9-0.8-0.3-0.20.30.4
Na content in liver0.30.30.60.10.60.30.40.10.40.60.40.50.5-0.8-0.7-0.7-0.8
Rb content in liver0.10.10.6-0.8-0.4-0.2-0.1-0.1-0.10.0-0.2-0.1-0.30.40.10.30.5
Se content in liver0.50.61.30.6-0.4-0.6-0.7-1.0-1.1-1.0-1.0-1.1-1.0-0.4-0.00.50.3
Sr content in liver3.32.95.8-1.1-1.3-2.3-2.4-2.4-2.0-1.5-1.8-1.6-0.8-1.8-1.4-1.2-1.2
Zn content in liver0.20.20.6-0.10.0-0.2-0.2-0.5-0.3-0.3-0.4-0.40.1-0.7-0.8-0.6-0.3
Bone: minimum diameter0.10.31.1-0.4-0.10.70.60.40.20.30.20.1-0.11.00.70.70.6
Time in familiar zone, hab. session 10.20.21.00.10.0-0.1-0.10.10.10.3-0.1-0.2-0.60.50.31.01.0
Time in novel zone, hab. session 10.30.30.70.80.60.80.70.60.50.30.60.40.40.20.3-0.1-0.1
Total zone transitions, hab. session 11.31.83.9-0.5-1.3-1.6-1.4-1.6-1.7-2.0-1.7-1.7-1.2-1.0-0.60.1-0.1
Total locomotion distance, hab. session 10.50.71.50.1-0.4-0.7-0.6-1.1-1.1-1.2-1.1-1.1-0.6-1.1-0.9-0.2-0.3
Locomotion velocity, hab. session 10.60.81.6-0.3-0.6-0.8-0.6-1.1-1.2-1.3-1.1-1.1-0.6-1.2-1.0-0.2-0.4
Time in familiar zone, hab. session 20.30.30.70.90.1-0.7-0.8-0.5-0.5-0.3-0.4-0.6-0.5-0.7-0.40.20.2
Time in novel zone, hab. session 20.20.21.7-1.3-0.30.30.40.0-0.1-0.1-0.10.20.30.3-0.1-0.5-0.5
Total zone transitions, hab. session 20.30.42.1-1.5-0.6-0.4-0.4-0.5-0.4-0.6-0.5-0.4-0.5-0.4-0.70.3-0.1
Total locomotion distance, hab. session 20.30.41.9-1.4-0.9-0.2-0.1-0.3-0.5-0.7-0.4-0.4-0.80.50.30.90.4
Locomotion velocity, hab. session 20.30.42.3-1.5-0.9-0.3-0.2-0.3-0.5-0.6-0.4-0.4-0.70.30.00.70.3
Novel to familiar place preference ratio0.91.03.41.81.11.51.51.00.90.60.70.80.90.20.3-0.4-0.2
Novelty place preference1.01.14.32.11.31.61.61.00.90.60.70.80.90.00.1-0.4-0.3
Time in novel zone, NPP test1.21.34.82.21.51.71.61.01.00.70.70.91.0-0.10.0-0.6-0.5
Total zone transitions, NPP test1.01.42.8-1.2-1.3-1.3-1.1-1.4-1.4-1.7-1.5-1.4-1.2-0.8-0.70.5-0.1
Total locomotion distance, NPP test0.10.20.5-0.7-0.6-0.3-0.1-0.2-0.3-0.7-0.3-0.3-0.40.10.10.5-0.0
Locomotion velocity, NPP test0.30.51.0-1.0-1.0-0.7-0.6-0.6-0.7-1.0-0.7-0.7-0.80.0-0.00.70.2
Intraocular pressure0.30.40.80.90.30.60.60.80.60.20.50.60.30.90.80.30.8
Delta distance traveled before/after self-admin2.62.76.60.92.61.71.61.51.92.21.51.71.7-1.2-1.7-1.2-1.0
Delta ambulatory time before/after self-admin1.82.35.10.72.31.71.61.61.92.01.41.61.5-0.7-1.3-0.9-0.8
Parametrial fat weight0.92.14.81.52.20.40.20.20.91.70.81.01.5-2.2-2.0-1.9-1.5
Pavlov. Cond. lever latency0.20.21.20.20.11.10.90.60.40.00.30.40.30.40.40.10.1
Pavlov. Cond. magazine entry latency1.41.83.6-1.3-1.5-1.9-1.8-1.4-1.4-1.1-1.4-1.4-1.50.60.60.91.3
Pavlov. Cond. change in total contacts2.22.34.0-2.0-1.8-2.0-1.9-1.8-1.7-1.4-1.7-1.6-1.70.30.00.80.8
Pavlov. Cond. index score0.50.72.3-1.0-0.7-1.5-1.3-0.9-0.8-0.3-0.7-0.8-0.90.1-0.10.40.5
Pavlov. Cond. latency score0.40.51.9-0.7-0.5-1.4-1.2-0.8-0.6-0.2-0.6-0.6-0.70.0-0.10.30.4
Pavlov. Cond. lever contacts0.60.72.8-0.8-0.4-1.7-1.4-1.1-0.7-0.1-0.6-0.6-0.5-0.6-0.7-0.2-0.2
Pavlov. Cond. magazine entry number1.31.63.71.51.41.91.81.51.41.11.31.41.3-0.10.0-0.5-0.6
Pavlov. Cond. intertrial magazine entries1.01.24.0-0.60.80.50.40.20.40.60.30.61.2-1.6-1.7-1.7-2.0
Pavlov. Cond. lever-magazine prob. diff.0.70.82.7-1.0-0.8-1.6-1.5-1.1-0.9-0.5-0.9-0.9-0.90.0-0.10.40.5
Pavlov. Cond. response bias0.91.13.1-1.3-1.0-1.8-1.6-1.3-1.1-0.6-1.0-1.1-1.1-0.1-0.20.40.6
Pavlov. Cond. lever latency0.40.61.3-0.0-0.6-0.2-0.3-0.6-0.9-1.0-1.1-1.1-1.10.20.21.00.8
Pavlov. Cond. magazine entry latency0.60.73.8-1.9-0.7-0.7-0.6-0.7-0.6-0.2-0.4-0.10.3-0.6-0.7-1.2-0.8
Pavlov. Cond. change in total contacts1.72.76.1-0.11.41.61.82.02.22.52.32.31.80.90.5-0.5-0.2
Pavlov. Cond. index score0.50.62.1-0.90.40.20.40.30.60.90.80.91.2-0.4-0.5-1.5-1.0
Pavlov. Cond. latency score0.60.72.6-1.00.40.10.30.30.60.90.70.91.3-0.6-0.7-1.6-1.2
Pavlov. Cond. lever contacts0.50.71.4-0.00.70.20.40.60.81.01.21.01.2-0.5-0.4-1.1-0.9
Pavlov. Cond. magazine entry number0.40.52.20.8-0.3-0.3-0.3-0.3-0.5-0.6-0.5-0.8-1.20.40.51.50.9
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.40.30.20.20.00.20.40.10.20.2-0.3-0.7-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.8-0.80.30.20.30.30.60.80.70.91.1-0.3-0.4-1.3-0.9
Pavlov. Cond. response bias0.20.30.7-0.60.20.20.30.50.60.80.80.80.80.0-0.0-0.8-0.5
Time in closed arm before self-admin0.10.20.6-0.8-0.1-0.30.2-0.2-0.30.20.0-0.10.1-0.7-0.6-0.5-0.4
Time in closed arm after self-admin0.50.51.8-1.00.5-0.0-0.0-0.10.00.50.00.20.5-1.2-1.3-1.1-0.9
Time in open arm before self-admin0.20.30.50.40.70.2-0.00.20.50.40.40.50.7-0.7-0.6-0.6-0.7
Time in open arm after self-admin0.10.10.91.0-0.0-0.3-0.5-0.2-0.0-0.3-0.0-0.2-0.1-0.20.1-0.2-0.1
Bone: periosteal estimation0.81.73.80.50.61.61.71.51.21.11.00.8-0.02.01.51.51.6
Bone: periosteal perimeter1.52.65.21.31.32.32.31.91.61.71.31.00.01.91.41.81.7
Bone: post-yield work0.50.72.1-0.8-0.8-0.1-0.2-0.4-0.5-0.4-0.7-0.7-1.21.10.61.41.2
Progressive ratio test 1 active lever presses2.12.55.7-2.4-2.3-1.3-1.2-1.2-1.4-1.7-1.5-1.3-1.71.61.21.61.5
Progressive ratio test 1 breakpoint1.92.35.2-2.3-2.2-1.3-1.2-1.1-1.3-1.6-1.4-1.2-1.61.51.11.41.4
Progressive ratio test 1 inactive lever presses1.31.88.1-2.8-2.1-1.1-0.9-0.9-1.0-1.1-0.9-0.7-1.11.51.20.91.1
Progressive ratio test 2 active lever presses2.63.17.9-2.8-2.2-1.9-1.8-2.1-2.0-1.9-2.0-1.7-1.80.5-0.00.80.8
Progressive ratio test 2 breakpoint3.03.57.9-2.8-2.4-2.0-1.9-2.1-2.1-2.0-2.1-1.8-2.00.70.21.01.0
Progressive ratio test 2 inactive lever presses2.13.46.8-2.6-2.1-2.4-2.2-2.4-2.2-2.0-2.1-1.9-1.6-0.5-0.70.10.2
Incentive Sensitization - Responses0.81.12.5-1.3-1.0-1.2-1.3-1.6-1.3-1.1-1.3-1.1-1.0-0.5-0.7-0.1-0.1
Incentive Sensitization - Breakpoint0.81.12.3-1.3-1.0-1.2-1.3-1.5-1.3-1.1-1.3-1.1-0.9-0.5-0.6-0.1-0.1
Sum of active levers in priming session hrs 5-60.00.00.40.60.10.10.20.10.10.30.10.10.10.10.2-0.0-0.1
Progressive ratio0.10.20.4-0.2-0.10.50.10.60.30.10.50.60.60.50.5-0.2-0.4
Food seeking constrained by brief footshock0.81.02.0-0.4-1.0-0.6-0.8-0.5-1.0-0.9-1.0-1.2-1.31.00.81.31.4
Seeking ratio, punishment vs. effort0.40.51.5-0.3-0.4-0.6-0.4-0.7-0.7-0.3-0.8-1.0-1.10.20.00.91.2
Retroperitoneal fat weight1.25.111.03.32.93.02.62.42.63.02.32.41.70.80.8-0.10.1
Reaction time number correct0.51.02.00.5-0.6-1.2-1.2-1.1-1.1-1.4-1.1-1.4-1.0-0.7-0.40.50.3
Reaction time mean minus median0.00.10.40.20.10.40.60.40.40.20.20.40.40.30.3-0.10.2
Reaction time mean minus median AUC0.10.30.70.60.60.70.80.70.60.60.50.70.8-0.00.0-0.5-0.3
Reaction time num false alarms0.00.10.10.30.2-0.00.3-0.4-0.3-0.1-0.1-0.3-0.1-0.3-0.4-0.1-0.2
Reaction time num false alarms AUC0.00.10.10.30.1-0.10.2-0.4-0.4-0.3-0.1-0.3-0.1-0.4-0.3-0.2-0.3
Reaction time trials correct on left0.51.02.00.5-0.6-1.2-1.2-1.1-1.1-1.4-1.1-1.4-1.0-0.7-0.40.50.3
Reaction time trials on left0.61.12.40.4-0.7-1.3-1.4-1.3-1.3-1.5-1.3-1.5-1.1-0.6-0.40.50.4
Reaction time mean0.50.81.70.70.71.01.31.11.11.01.01.21.20.20.3-0.7-0.2
Reaction time mean AUC0.30.51.10.60.50.81.11.00.90.70.70.91.00.10.2-0.6-0.2
Median of all reaction times0.50.71.50.60.60.91.21.11.00.90.91.11.00.30.4-0.5-0.0
Reaction time omissions2.43.55.6-1.1-2.4-1.6-1.6-1.8-2.0-2.2-2.1-2.0-2.21.31.41.81.9
Reaction time false alarm rate0.10.10.40.10.30.40.70.00.10.30.30.30.3-0.1-0.1-0.4-0.4
Reaction time premature initiation rate0.10.21.0-1.0-0.00.40.20.50.30.60.20.30.00.70.10.30.2
Reaction time premature initiations0.00.10.5-0.7-0.1-0.1-0.30.0-0.10.0-0.2-0.2-0.20.2-0.20.20.0
Std. dev. reaction times0.30.50.90.70.80.91.00.80.90.80.70.90.90.00.0-0.5-0.2
Reaction time trials completed0.61.12.40.4-0.7-1.3-1.4-1.3-1.3-1.5-1.3-1.5-1.1-0.6-0.40.50.4
Reaction time trials AUC0.40.81.70.5-0.6-1.1-1.1-1.0-1.0-1.3-1.0-1.3-1.0-0.5-0.30.50.3
Run reversals in cocaine runway, females0.50.51.11.11.10.40.90.60.60.80.50.50.6-0.7-0.6-0.4-0.5
Run reversals in cocaine runway, males0.70.71.90.20.31.21.41.21.0-0.00.81.11.10.40.3-0.4-0.5
Latency to leave start box in cocaine runway1.01.14.51.2-0.30.80.60.90.6-0.10.70.7-0.31.82.11.31.2
Latency to leave start box in cocaine runway, F0.91.14.30.5-0.60.40.10.50.4-0.10.40.3-0.81.92.11.71.5
Latency to leave start box in cocaine runway, M0.40.42.01.40.40.70.80.80.50.10.50.60.40.50.7-0.00.1
Std. dev. time between licks in bursts0.20.30.8-0.10.20.50.20.70.70.50.80.90.60.30.4-0.2-0.2
Total sessions with >9 infusions1.11.34.3-1.7-1.4-0.4-0.20.1-0.3-0.7-0.4-0.3-1.02.11.51.61.5
Short access day 1 total inactive lever presses1.41.93.5-1.60.51.71.81.81.61.41.61.91.31.20.6-0.2-0.2
Short access day 10 total inactive lever presses1.84.36.90.72.51.71.91.82.22.52.12.22.6-1.6-2.0-2.3-2.1
Short access day 1 total infusions0.20.31.5-1.2-0.20.10.50.50.40.30.50.60.30.70.30.10.2
Short access day 10 total infusions1.01.33.8-1.5-1.5-0.1-0.2-0.0-0.5-0.9-0.4-0.5-1.01.91.51.61.5
Short access total infusions1.41.84.9-2.2-1.9-0.6-0.4-0.3-0.8-1.1-0.8-0.7-1.32.01.41.71.7
Short access day 1 locomotion0.20.30.9-1.00.20.40.40.50.60.50.70.70.60.40.1-0.2-0.1
Short access day 10 total locomotion0.50.93.6-1.90.2-0.2-0.3-0.4-0.00.80.40.30.7-1.1-1.5-1.4-1.6
Short access total locomotion0.20.33.1-1.8-0.4-0.1-0.3-0.2-0.10.20.10.1-0.00.40.0-0.0-0.2
One hour access (0.3 mA shock)6.67.612.1-3.3-3.4-3.5-3.2-3.2-3.2-3.3-3.1-3.0-2.80.40.11.31.4
Compulsive drug intake0.70.82.1-0.5-0.1-1.3-0.9-1.0-0.6-0.3-0.9-0.40.2-1.4-1.4-1.1-0.6
One hour access (shock baseline)1.92.95.6-1.8-2.4-1.5-1.6-1.4-1.8-2.1-1.5-1.7-2.01.31.21.61.5
Social response proportion2.02.38.80.3-1.00.60.40.6-0.0-0.40.0-0.1-1.22.83.02.52.4
Social responses0.71.02.0-1.0-1.2-0.4-0.7-0.4-0.7-0.9-0.7-0.6-1.21.31.11.41.3
Social time1.72.45.0-2.2-1.9-1.7-2.0-1.7-1.8-1.4-1.8-1.6-1.70.30.10.81.0
Soleus weight0.72.28.2-2.00.6-0.8-0.9-1.1-0.40.8-0.6-0.30.7-2.4-2.9-2.1-1.8
Bone: stiffness0.40.71.5-0.40.51.21.10.60.71.20.60.3-0.21.10.61.11.1
Tibialis anterior weight2.17.011.8-3.3-3.1-3.2-3.2-3.4-3.4-2.8-3.3-3.0-2.4-0.7-0.50.10.2
Time to tail flick, vehicle, before self-admin0.10.10.1-0.4-0.30.00.30.0-0.2-0.3-0.2-0.2-0.10.30.30.2-0.0
Time to tail flick, vehicle, after self-admin1.31.73.00.41.70.90.81.01.21.41.21.11.7-1.4-1.5-1.5-1.6
Time to tail flick, test, before self-admin1.11.22.3-0.9-1.2-1.2-1.5-1.2-1.3-1.4-1.4-1.3-1.0-0.1-0.00.30.5
Time to tail flick, test, after self-admin0.20.20.90.20.4-0.4-0.2-0.2-0.00.2-0.1-0.00.0-0.9-0.8-0.4-0.4
Delta time to tail flick, vehicle, before/after SA0.50.51.10.10.70.80.50.80.90.91.10.90.90.10.0-0.4-0.3
Delta time to tail flick, test, before/after SA0.40.52.00.40.6-0.6-0.4-0.6-0.10.4-0.0-0.10.1-1.4-1.1-0.8-1.0
Tibia length0.30.72.40.40.51.11.10.80.70.80.20.4-0.01.20.80.91.6
Ambulatory time before self-admin0.50.72.1-1.3-1.4-0.8-0.6-0.6-0.9-1.0-0.7-0.8-0.80.50.60.40.5
Ambulatory time after self-admin0.20.30.7-0.60.60.40.50.50.50.70.40.30.4-0.5-0.9-0.4-0.2
Bone: tissue strength0.20.20.60.60.60.80.70.30.50.60.40.50.10.20.30.10.0
Total heroin consumption1.41.62.8-1.3-1.7-1.0-1.0-1.2-1.5-1.5-1.5-1.5-1.40.90.71.31.0
Bone: trabecular number0.10.10.80.90.40.30.20.10.20.2-0.00.10.1-0.3-0.10.0-0.1
Bone: trabecular spacing0.20.31.1-0.70.30.40.50.30.50.90.20.2-0.10.60.10.51.0
Bone: trabecular thickness0.20.31.80.50.3-0.1-0.3-0.2-0.00.00.1-0.00.3-1.0-0.6-0.5-1.4
Bone: trabecular tissue density0.40.61.90.10.7-0.4-0.5-0.20.30.60.50.40.7-1.4-1.1-1.1-1.2
Water consumed over 24 hours0.60.73.3-1.10.4-0.4-0.5-0.5-0.30.2-0.4-0.30.4-1.4-1.8-1.1-1.2
Number of responses in last shaping day3.13.48.8-3.0-2.7-1.6-1.4-1.4-1.9-1.8-1.6-1.6-2.01.61.31.61.4