Tmem179

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Tmem179 0.04 0.04 5.2e-04 0.02 0.04 0.03 0.03 1.1e-03 8.3e-05 2.6e-04 3.7e-04
2 LHb mRNA stability Tmem179 0.13 0.11 3.4e-03 0.1 0.09 0.09 0.08 2.3e-03 3.3e-03 3.4e-03 6.2e-03
3 Adipose gene expression Tmem179 0.12 0.07 1.3e-11 0.08 0.08 0.08 0.09 1.2e-09 1.4e-09 2.1e-09 3.9e-10
4 OFC gene expression Tmem179 0.19 0.14 3.3e-04 0.14 0.14 0.14 0.13 3.9e-04 3.6e-04 3.1e-04 4.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.00.00.00.1-0.1-0.10.2
Area under the delay curve0.20.20.4-0.6-0.0-0.30.7
BMI with tail2.16.78.8-2.72.7-3.01.9
BMI without tail0.51.01.5-1.20.8-1.20.4
Body weight0.62.44.32.1-1.81.3-0.6
Weight adjusted by age0.40.40.80.7-0.90.60.3
Bone surface0.00.00.1-0.30.2-0.2-0.2
Bone volume0.00.00.1-0.2-0.1-0.2-0.2
Breakpoint value in progressive ratio session0.30.30.7-0.50.8-0.5-0.2
Number of licking bursts0.10.20.4-0.60.4-0.2-0.2
Context. condit. distance diff. score3.74.45.52.3-2.02.2-1.8
Locomotion velocity, session 10.10.10.20.5-0.40.40.0
Locomotion distance, session 10.60.80.9-0.70.9-0.91.0
Locomotion velocity, session 20.00.00.0-0.20.1-0.0-0.1
Locomotion distance, session 20.20.30.4-0.60.6-0.60.3
Locomotion velocity, session 30.10.10.2-0.10.3-0.40.3
Locomotion distance, session 30.00.00.00.0-0.0-0.0-0.2
Stereotopy head waving bouts, day 30.10.10.20.1-0.20.2-0.4
Stereotopy head waving duration, day 30.20.20.30.3-0.40.4-0.6
Locomotion velocity, session 70.30.30.9-0.30.5-0.50.9
Locomotion distance, session 70.60.80.9-0.91.0-0.80.8
Stereotopy head waving bouts, day 71.31.52.31.5-1.51.1-0.5
Stereotopy head waving duration, day 70.50.61.11.0-1.00.7-0.1
Locomotion velocity, session 81.11.32.11.5-1.21.0-0.8
Locomotion distance, session 80.30.51.01.0-0.60.7-0.3
Degree of sensitization distance0.30.30.4-0.60.6-0.40.5
Degree of sensitization stereotypy0.30.30.60.8-0.80.40.1
Conditioned locomotion1.21.41.81.3-1.31.2-0.9
Cocaine response after cond. corrected0.70.81.3-0.70.9-1.20.7
Cocaine response after cond. not corrected1.71.93.0-1.31.5-1.70.8
Cocaine response before conditioning1.31.52.4-1.51.3-1.40.3
Saline control response0.00.00.10.2-0.2-0.1-0.2
Bone: connectivity density0.30.50.70.8-0.60.7-0.4
Bone: cortical apparent density5.77.58.52.6-2.82.9-2.6
Bone: cortical area0.30.51.20.4-0.60.4-1.1
Bone: cortical porosity0.40.40.50.7-0.70.6-0.5
Bone: cortical porosity0.10.10.20.4-0.30.2-0.1
Bone: cortical thickness0.20.30.60.5-0.60.3-0.8
Bone: cortical thickness0.91.01.51.0-1.20.8-1.0
Bone: cortical tissue density5.97.78.82.6-2.93.0-2.6
Condit. Reinf. active minus inactive responses0.60.70.9-0.80.8-0.90.8
Condit. Reinf. active-inactive response ratio2.62.83.2-1.61.8-1.71.6
Condit. Reinf. active responses0.10.10.2-0.20.2-0.50.5
Condit. Reinf. inactive responses1.41.62.01.4-1.41.3-1.0
Incentive salience index mean0.50.71.0-0.50.7-0.91.0
Condit. Reinf. lever presses0.10.20.4-0.20.3-0.50.6
Condit. Reinf. active minus inactive responses1.01.21.51.1-1.11.2-1.1
Condit. Reinf. active-inactive response ratio0.80.91.20.8-0.81.1-1.0
Condit. Reinf. active responses0.20.20.40.3-0.50.4-0.6
Condit. Reinf. inactive responses0.30.30.6-0.70.4-0.80.4
Condit. Reinf. lever presses0.50.61.1-1.00.9-0.8-0.0
Condit. Reinf. lever reinforcers received0.20.30.40.4-0.60.6-0.6
Conditioned reinforcement - actives2.02.02.41.3-1.51.5-1.3
Conditioned reinforcement - inactives0.50.51.10.7-1.00.7-0.3
Conditioned locomotion0.10.10.2-0.30.3-0.50.3
Patch foraging indifference point 0 sec4.26.77.92.8-2.62.5-2.5
Patch foraging indifference point AUC1.72.03.31.8-1.21.2-1.3
Delay disc. indifference point, 0s delay0.30.40.90.6-1.00.4-0.0
Delay disc. indifference point, 16s delay0.20.20.5-0.70.3-0.20.1
Delay disc. indifference point, 2s delay0.80.91.9-1.40.1-0.81.0
Delay disc. indifference point, 24s delay0.40.40.6-0.80.1-0.60.7
Delay disc. indifference point, 4s delay0.30.30.90.1-0.90.60.1
Delay disc. indifference point, 8s delay0.10.10.2-0.30.2-0.20.5
Indifference point function ln k1.21.62.21.3-1.51.4-0.8
Indifference point function log k1.21.62.21.3-1.51.4-0.8
Patch foraging total patch changes 0 sec4.97.89.53.1-2.82.7-2.6
Patch foraging total patch changes 12 sec3.24.14.72.2-1.92.0-2.0
Patch foraging total patch changes 18 sec1.11.41.81.4-1.20.9-1.3
Patch foraging total patch changes 24 sec0.30.40.60.8-0.60.5-0.5
Patch foraging total patch changes 6 sec2.13.14.32.1-1.51.4-1.9
Patch foraging time to switch 0 sec9.414.516.1-4.03.9-4.03.4
Patch foraging water rate 0 sec16.225.927.15.2-5.15.2-4.9
Patch foraging water rate 12 sec8.913.717.23.7-4.04.1-2.9
Patch foraging water rate 18 sec4.86.58.12.5-2.82.6-2.1
Patch foraging water rate 24 sec4.46.16.52.3-2.52.5-2.5
Patch foraging water rate 6 sec4.66.77.32.6-2.72.6-2.4
Seeking ratio, delayed vs. immediate footshock0.30.40.80.7-0.90.4-0.2
Distance traveled before self-admin0.50.51.0-1.00.6-0.70.3
Distance traveled after self-admin0.40.50.90.6-0.90.7-0.5
Extensor digitorum longus weight6.726.336.06.0-5.55.3-3.3
Bone: elastic displacement0.30.40.70.4-0.80.6-0.5
Bone: elastic work0.10.10.2-0.3-0.10.1-0.5
Bone: endosteal estimation0.10.20.4-0.60.4-0.1-0.3
Bone: endosteal perimeter0.10.20.4-0.30.3-0.2-0.7
Epididymis fat weight3.27.49.3-2.62.9-3.02.3
Delta time in closed arm before/after self-admin0.10.10.20.2-0.50.20.2
Delta time in open arm before/after self-admin0.40.40.50.7-0.60.4-0.7
Diff in mean of infusions in LGA sessions0.10.10.20.00.5-0.3-0.3
Delay discount exponential model param0.20.20.40.50.20.2-0.6
Extinction: sum of active levers before priming0.10.10.1-0.30.2-0.30.3
Active lever presses in extinction session 61.61.52.21.3-1.11.5-1.0
Bone: final force0.30.61.60.3-0.40.6-1.3
Bone: final moment0.40.71.70.4-0.60.7-1.3
Food consumed during 24 hour testing period0.50.61.01.0-0.90.6-0.4
Glucose0.30.40.80.3-0.70.5-0.9
Heart weight0.00.00.0-0.00.10.1-0.1
Delay discount hyperbolic model param0.30.30.60.60.10.3-0.8
Intermittent access intake day 1-15 change1.41.31.8-1.31.2-1.30.7
Intermittent access intake escalation1.31.31.7-1.31.2-1.30.7
Intermittent access intake escalation 20.30.30.4-0.60.5-0.60.3
Intermitt. access day 1 inactive lever presses2.42.63.61.9-1.51.9-1.0
Intermitt. access day 15 inactive lever presses0.91.01.21.0-1.01.1-0.7
Intermitt. access escalation Index0.20.20.40.3-0.60.4-0.2
Intermittent access day 1 total infusions0.10.10.2-0.10.4-0.40.1
Intermittent access day 15 total infusions1.21.31.8-1.21.3-1.40.6
Intermittent access terminal intake (last 3 days)1.51.72.4-1.41.4-1.60.6
Intermittent access total infusions0.30.30.6-0.50.7-0.80.1
Intermittent access day 1 locomotion0.20.20.5-0.40.7-0.6-0.1
Intermittent access day 15 total locomotion0.00.00.0-0.10.2-0.2-0.2
Intermittent access total locomotion0.10.10.2-0.20.4-0.5-0.1
Intermittent access standard deviation2.32.53.8-1.51.7-2.00.9
Left kidney weight1.95.57.92.8-2.42.2-1.8
Right kidney weight1.23.45.02.2-1.91.8-1.2
Cocaine induced anxiety1.31.52.31.0-1.11.5-1.2
Post-drug Anxiety1.01.11.60.8-0.71.2-1.3
Baseline Anxiety1.21.32.0-1.11.1-1.40.8
Tail length4.012.215.53.9-3.93.5-2.3
Length with tail6.021.930.95.6-5.14.7-2.8
Length without tail2.96.310.13.2-2.52.6-1.4
Times rat made contact with spout0.00.00.10.2-0.20.2-0.1
Lifetime Intake0.10.10.2-0.40.3-0.4-0.1
Liver weight, left2.03.23.41.8-1.81.7-1.9
Liver weight, right0.10.20.40.4-0.1-0.00.7
Locomotor activity0.10.20.30.5-0.60.4-0.2
Locomotor testing distance0.20.40.40.6-0.60.7-0.5
Locomotor testing rearing1.72.63.7-1.81.9-1.70.9
Locomotion in novel chamber5.06.18.32.5-2.32.9-2.1
Locomotion in novel chamber post-restriction0.00.00.0-0.00.10.1-0.2
Fecal boli incidents, locomotor time 11.71.82.4-1.31.0-1.51.5
Change in fecal boli incidents, locomotor task2.52.43.21.8-1.21.7-1.3
Time >=10cm from walls, locomotor time 10.10.10.30.50.4-0.2-0.0
Bouts of movement, locomotor time 11.81.93.1-1.41.0-1.81.3
Total resting periods, locomotor time 11.71.93.0-1.41.0-1.71.3
Rest time, locomotor task time 10.10.10.2-0.4-0.1-0.30.0
Distance moved, locomotor task time 10.20.20.6-0.60.8-0.0-0.0
Vertical activity count, locomotor time 10.20.30.60.10.10.7-0.8
Time >=10cm from walls, locomotor time 20.30.30.90.9-0.20.5-0.4
Bouts of movement, locomotor time 21.41.63.30.9-1.81.2-0.8
Total resting periods, locomotor time 21.21.33.00.7-1.71.1-0.7
Rest time, locomotor task time 20.10.10.30.1-0.60.4-0.2
Distance moved, locomotor task time 20.40.51.2-0.61.1-0.50.1
Vertical activity count, locomotor time 20.10.10.20.20.30.3-0.5
Light reinforcement 10.10.10.40.1-0.20.1-0.6
Light reinforcement 21.72.33.0-1.61.7-1.60.9
Bone: marrow area0.10.20.4-0.60.3-0.1-0.4
Bone: maximum diameter0.20.30.4-0.70.5-0.7-0.3
Bone: maximum force0.30.51.40.3-0.40.5-1.2
Bone: maximum moment0.30.51.20.4-0.50.5-1.1
Mean time between licks in bursts0.30.40.5-0.70.7-0.70.2
Mean num. licks in bursts0.20.20.50.7-0.50.30.2
Cd content in liver2.22.43.01.6-1.61.7-1.2
Co content in liver1.11.31.91.4-1.21.3-0.3
Cu content in liver1.92.33.1-1.81.8-1.50.8
Fe content in liver0.60.71.0-1.01.0-0.80.2
K content in liver0.10.10.20.5-0.30.2-0.0
Mg content in liver0.10.10.10.3-0.40.4-0.3
Mn content in liver0.50.50.70.8-0.80.9-0.3
Na content in liver0.50.50.7-0.70.8-0.80.6
Rb content in liver0.91.11.41.1-1.21.2-0.6
Se content in liver0.00.00.1-0.10.1-0.20.1
Sr content in liver0.60.61.10.5-0.60.7-1.1
Zn content in liver0.10.10.20.2-0.40.2-0.3
Bone: minimum diameter0.91.72.21.2-1.31.3-1.5
Time in familiar zone, hab. session 10.10.10.20.10.1-0.10.5
Time in novel zone, hab. session 10.30.30.6-0.80.4-0.60.1
Total zone transitions, hab. session 10.10.10.1-0.40.3-0.20.2
Total locomotion distance, hab. session 10.50.70.80.8-0.90.9-0.8
Locomotion velocity, hab. session 11.01.41.51.1-1.21.2-1.1
Time in familiar zone, hab. session 20.20.20.70.10.3-0.30.9
Time in novel zone, hab. session 20.20.20.4-0.60.2-0.4-0.3
Total zone transitions, hab. session 20.50.71.0-0.70.7-1.00.8
Total locomotion distance, hab. session 20.40.50.70.6-0.80.5-0.8
Locomotion velocity, hab. session 20.50.70.90.8-1.00.6-0.9
Novel to familiar place preference ratio0.60.60.7-0.90.7-0.80.8
Novelty place preference0.40.40.6-0.80.5-0.60.6
Time in novel zone, NPP test0.20.20.4-0.50.4-0.50.6
Total zone transitions, NPP test0.20.30.60.8-0.60.30.5
Total locomotion distance, NPP test0.30.40.70.8-0.80.6-0.1
Locomotion velocity, NPP test0.30.40.60.8-0.80.6-0.2
Intraocular pressure0.30.41.4-0.3-0.1-0.21.2
Delta distance traveled before/after self-admin0.50.60.80.9-0.90.6-0.5
Delta ambulatory time before/after self-admin1.61.72.71.5-1.61.2-0.7
Parametrial fat weight0.00.10.1-0.30.3-0.20.1
Pavlov. Cond. lever latency0.70.91.20.7-0.91.0-1.1
Pavlov. Cond. magazine entry latency0.50.60.9-0.50.8-0.80.9
Pavlov. Cond. change in total contacts0.20.20.3-0.30.4-0.60.5
Pavlov. Cond. index score0.91.21.6-0.81.0-1.21.3
Pavlov. Cond. latency score0.70.91.1-0.70.9-1.01.1
Pavlov. Cond. lever contacts1.21.41.7-1.11.2-1.31.1
Pavlov. Cond. magazine entry number0.60.81.10.6-0.91.0-1.1
Pavlov. Cond. intertrial magazine entries5.66.79.13.0-2.82.7-1.6
Pavlov. Cond. lever-magazine prob. diff.0.81.01.3-0.80.9-1.11.1
Pavlov. Cond. response bias0.91.01.5-0.71.0-1.11.2
Pavlov. Cond. lever latency0.91.32.11.4-1.21.2-0.1
Pavlov. Cond. magazine entry latency2.63.04.3-1.91.8-2.11.0
Pavlov. Cond. change in total contacts3.04.26.0-2.52.3-2.10.9
Pavlov. Cond. index score2.43.14.0-2.01.9-1.90.9
Pavlov. Cond. latency score2.63.24.0-2.02.0-2.01.0
Pavlov. Cond. lever contacts1.41.92.8-1.71.5-1.60.4
Pavlov. Cond. magazine entry number2.02.43.31.7-1.61.8-0.9
Pavlov. Cond. intertrial magazine entries4.45.86.92.5-2.62.6-1.9
Pavlov. Cond. lever-magazine prob. diff.2.93.74.9-2.22.1-2.11.0
Pavlov. Cond. response bias1.52.12.9-1.71.5-1.70.5
Time in closed arm before self-admin4.34.97.7-2.52.8-2.20.9
Time in closed arm after self-admin1.31.32.6-1.61.0-1.00.7
Time in open arm before self-admin5.56.07.72.7-2.82.8-1.2
Time in open arm after self-admin4.04.57.02.6-2.22.0-1.4
Bone: periosteal estimation0.10.20.9-0.1-0.20.2-1.0
Bone: periosteal perimeter0.10.10.5-0.10.1-0.2-0.7
Bone: post-yield work1.92.63.41.8-1.51.8-1.2
Progressive ratio test 1 active lever presses0.00.00.0-0.1-0.1-0.1-0.2
Progressive ratio test 1 breakpoint0.00.10.1-0.30.1-0.3-0.1
Progressive ratio test 1 inactive lever presses2.62.84.31.8-2.11.7-0.9
Progressive ratio test 2 active lever presses0.00.00.0-0.10.0-0.0-0.2
Progressive ratio test 2 breakpoint0.00.00.10.1-0.10.1-0.3
Progressive ratio test 2 inactive lever presses0.60.71.00.6-0.91.0-0.8
Incentive Sensitization - Responses0.00.00.0-0.1-0.00.00.0
Incentive Sensitization - Breakpoint0.00.00.00.0-0.10.2-0.0
Sum of active levers in priming session hrs 5-60.50.50.8-0.90.7-0.80.2
Progressive ratio0.30.40.6-0.2-0.70.8-0.5
Food seeking constrained by brief footshock0.40.50.90.4-0.90.7-0.5
Seeking ratio, punishment vs. effort0.10.10.30.50.1-0.10.0
Retroperitoneal fat weight0.30.81.3-0.70.7-1.01.2
Reaction time number correct3.04.35.32.3-2.22.2-1.4
Reaction time mean minus median0.20.30.9-0.20.0-0.31.0
Reaction time mean minus median AUC0.20.31.10.0-0.3-0.11.0
Reaction time num false alarms1.01.32.11.3-1.41.1-0.6
Reaction time num false alarms AUC1.31.82.71.4-1.61.3-0.8
Reaction time trials correct on left3.04.35.32.3-2.22.2-1.4
Reaction time trials on left3.14.45.42.3-2.32.3-1.4
Reaction time mean1.01.32.5-1.10.9-0.91.6
Reaction time mean AUC0.60.81.9-0.80.6-0.61.4
Median of all reaction times0.50.71.3-0.80.7-0.61.2
Reaction time omissions1.31.83.41.4-1.91.20.0
Reaction time false alarm rate0.10.10.30.3-0.50.2-0.1
Reaction time premature initiation rate0.60.81.30.7-0.71.1-1.1
Reaction time premature initiations2.33.24.11.8-1.62.0-1.7
Std. dev. reaction times0.50.71.8-0.80.4-0.61.3
Reaction time trials completed3.14.45.42.3-2.32.3-1.4
Reaction time trials AUC3.24.65.62.4-2.32.3-1.5
Run reversals in cocaine runway, females1.41.42.1-1.41.2-1.10.9
Run reversals in cocaine runway, males0.20.20.40.0-0.20.4-0.7
Latency to leave start box in cocaine runway0.30.40.7-0.90.1-0.60.6
Latency to leave start box in cocaine runway, F0.40.40.8-0.90.4-0.80.4
Latency to leave start box in cocaine runway, M0.30.30.5-0.70.1-0.50.7
Std. dev. time between licks in bursts0.10.10.20.4-0.20.00.3
Total sessions with >9 infusions0.00.00.2-0.10.1-0.0-0.4
Short access day 1 total inactive lever presses0.10.10.20.2-0.50.40.2
Short access day 10 total inactive lever presses0.70.81.40.9-1.21.00.1
Short access day 1 total infusions0.40.40.60.4-0.50.7-0.8
Short access day 10 total infusions0.20.20.2-0.50.5-0.5-0.2
Short access total infusions0.10.20.3-0.50.3-0.3-0.5
Short access day 1 locomotion0.10.10.3-0.50.2-0.40.3
Short access day 10 total locomotion0.30.40.7-0.50.8-0.8-0.0
Short access total locomotion0.10.10.2-0.10.0-0.2-0.5
One hour access (0.3 mA shock)0.20.20.30.5-0.50.3-0.5
Compulsive drug intake0.10.10.20.4-0.30.10.3
One hour access (shock baseline)0.00.00.1-0.20.3-0.2-0.1
Social response proportion0.30.30.80.0-0.20.6-0.9
Social responses0.00.00.1-0.40.1-0.2-0.0
Social time1.41.83.01.1-1.51.7-0.7
Soleus weight0.31.02.51.6-0.90.40.7
Bone: stiffness1.52.33.11.5-1.31.5-1.8
Tibialis anterior weight0.41.22.21.5-1.11.0-0.6
Time to tail flick, vehicle, before self-admin0.70.71.21.1-0.90.70.6
Time to tail flick, vehicle, after self-admin0.10.10.30.6-0.40.20.1
Time to tail flick, test, before self-admin0.10.10.2-0.0-0.4-0.10.3
Time to tail flick, test, after self-admin1.81.93.11.8-1.01.4-1.1
Delta time to tail flick, vehicle, before/after SA0.10.10.20.2-0.10.0-0.5
Delta time to tail flick, test, before/after SA2.01.82.81.7-1.11.4-1.1
Tibia length0.10.41.30.2-0.50.3-1.1
Ambulatory time before self-admin0.80.81.6-1.30.8-0.90.2
Ambulatory time after self-admin0.00.00.1-0.2-0.3-0.20.0
Bone: tissue strength0.10.10.2-0.40.1-0.2-0.5
Total heroin consumption0.40.50.80.9-0.80.6-0.6
Bone: trabecular number0.20.40.50.7-0.70.6-0.3
Bone: trabecular spacing0.10.10.1-0.30.3-0.30.3
Bone: trabecular thickness0.00.10.10.2-0.30.2-0.3
Bone: trabecular tissue density0.00.00.1-0.20.1-0.2-0.1
Water consumed over 24 hours2.42.83.11.6-1.71.7-1.7
Number of responses in last shaping day0.40.40.6-0.70.8-0.70.3