Hub : Genes

Tmem150b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Tmem150b	0.06	0.04	5.4e-07	0.04	0.04	0.03	0.04	2.2e-05	1.8e-05	1.2e-04	1.3e-05
2	Adipose	alternative TSS	XM_039111106.2	0.03	0.02	3.6e-03	0.01	0.02	0.01	0.01	1.6e-02	3.9e-03	1.8e-02	1.7e-02
3	pVTA	alternative TSS	NM_001107476.1	0.05	0.04	7.4e-03	0	0.01	-0	0	1.1e-01	8.7e-02	7.8e-01	2.6e-01
4	Brain	mRNA stability	Tmem150b	0.06	0.06	3.7e-03	0.02	0.02	0.01	0.02	2.8e-03	3.3e-03	2.4e-02	6.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.2	0.3	0.3	-0.4	-0.4
Area under the delay curve	0.2	0.4	0.4	-0.6	-0.6	0.6	0.5
BMI with tail	0.5	1.9	2.2	-1.4	-1.3	1.4	1.5
BMI without tail	0.0	0.2	0.3	0.5	0.6	-0.3	0.0
Body weight	1.1	5.0	6.5	2.4	2.6	-2.2	-1.6
Weight adjusted by age	0.3	0.9	1.5	0.8	0.7	-1.0	-1.2
Bone surface	2.9	5.6	6.3	2.5	2.5	-2.4	-2.1
Bone volume	2.2	4.4	4.8	2.1	2.2	-2.1	-1.9
Breakpoint value in progressive ratio session	0.3	0.5	0.5	-0.7	-0.7	0.7	0.6
Number of licking bursts	0.0	0.1	0.1	-0.3	-0.3	0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.3	-0.4	-0.5	0.3	0.1
Locomotion velocity, session 1	0.4	0.5	1.0	-0.4	-0.9	-0.1	-1.0
Locomotion distance, session 1	2.2	2.8	5.0	1.5	1.1	-1.7	-2.2
Locomotion velocity, session 2	0.2	0.2	0.5	-0.5	-0.7	0.2	-0.4
Locomotion distance, session 2	1.8	2.5	3.3	1.5	1.3	-1.6	-1.8
Locomotion velocity, session 3	0.0	0.1	0.1	-0.3	-0.3	0.2	0.0
Locomotion distance, session 3	0.2	0.2	0.6	0.3	0.1	-0.4	-0.8
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.3	-0.2	0.4	0.5
Locomotion velocity, session 7	0.0	0.1	0.2	0.1	-0.0	-0.2	-0.4
Locomotion distance, session 7	0.0	0.1	0.2	-0.1	-0.3	-0.1	-0.4
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.5	0.5	-0.4	-0.2
Stereotopy head waving duration, day 7	0.1	0.2	0.3	0.4	0.5	-0.4	-0.2
Locomotion velocity, session 8	0.1	0.1	0.2	-0.2	-0.5	0.0	-0.4
Locomotion distance, session 8	0.1	0.2	0.5	0.3	0.0	-0.5	-0.7
Degree of sensitization distance	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0
Degree of sensitization stereotypy	0.0	0.0	0.1	0.2	0.3	-0.1	0.1
Conditioned locomotion	0.1	0.1	0.2	0.0	-0.1	-0.2	-0.5
Cocaine response after cond. corrected	1.3	2.0	3.5	-1.2	-0.9	1.5	1.9
Cocaine response after cond. not corrected	0.1	0.1	0.3	0.3	0.6	-0.2	0.3
Cocaine response before conditioning	7.6	9.1	9.7	3.1	2.8	-3.1	-3.1
Saline control response	0.1	0.2	0.6	-0.2	-0.3	-0.2	-0.8
Bone: connectivity density	0.0	0.0	0.1	-0.3	-0.2	0.2	0.2
Bone: cortical apparent density	0.1	0.1	0.4	0.0	-0.1	-0.2	-0.6
Bone: cortical area	0.8	1.3	1.4	1.2	1.2	-1.2	-1.0
Bone: cortical porosity	0.6	0.6	0.9	-0.8	-0.6	0.8	0.9
Bone: cortical porosity	0.2	0.2	0.5	-0.3	-0.1	0.4	0.7
Bone: cortical thickness	0.3	0.6	0.8	-0.8	-0.9	0.7	0.5
Bone: cortical thickness	0.1	0.1	0.3	0.2	0.2	-0.4	-0.6
Bone: cortical tissue density	0.1	0.1	0.3	-0.0	-0.1	-0.2	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	-0.4	0.5	0.5
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.0	-1.4	-1.3	1.4	1.4
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Condit. Reinf. inactive responses	3.0	4.0	4.2	2.0	1.8	-2.1	-2.0
Incentive salience index mean	0.0	0.1	0.1	0.2	0.3	-0.3	-0.2
Condit. Reinf. lever presses	0.7	1.1	1.2	1.0	1.0	-1.1	-1.0
Condit. Reinf. active minus inactive responses	3.3	5.1	5.5	2.3	2.2	-2.3	-2.2
Condit. Reinf. active-inactive response ratio	4.3	6.8	7.8	2.8	2.8	-2.7	-2.2
Condit. Reinf. active responses	3.0	4.4	5.0	2.1	1.9	-2.2	-2.2
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.4
Condit. Reinf. lever presses	0.6	0.8	1.4	1.1	1.2	-0.8	-0.3
Condit. Reinf. lever reinforcers received	4.0	5.6	6.4	2.4	2.1	-2.5	-2.5
Conditioned reinforcement - actives	0.1	0.3	0.5	0.6	0.7	-0.5	-0.2
Conditioned reinforcement - inactives	1.2	3.4	3.7	1.9	1.8	-1.9	-1.8
Conditioned locomotion	0.1	0.1	0.2	0.4	0.5	-0.3	-0.1
Patch foraging indifference point 0 sec	0.2	0.6	1.0	-0.9	-1.0	0.7	0.4
Patch foraging indifference point AUC	0.3	0.8	0.9	-0.9	-0.9	0.9	0.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.3	-0.4	-0.1	-0.6
Delay disc. indifference point, 16s delay	0.6	0.9	2.0	-0.6	-0.5	1.0	1.4
Delay disc. indifference point, 2s delay	0.5	0.5	0.8	-0.9	-0.9	0.7	0.3
Delay disc. indifference point, 24s delay	0.5	0.8	1.3	-0.7	-0.7	0.9	1.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	0.3	-0.2	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	-0.4	0.3	0.1
Indifference point function ln k	2.6	8.0	9.0	2.8	2.6	-2.9	-3.0
Indifference point function log k	2.6	8.0	9.0	2.8	2.6	-2.9	-3.0
Patch foraging total patch changes 0 sec	0.2	0.6	1.0	-0.9	-1.0	0.7	0.3
Patch foraging total patch changes 12 sec	0.3	0.3	0.4	-0.5	-0.5	0.6	0.7
Patch foraging total patch changes 18 sec	0.4	0.8	1.0	-1.0	-1.0	0.9	0.7
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	0.2	0.3	0.0	0.4
Patch foraging total patch changes 6 sec	0.8	1.4	1.5	-1.2	-1.2	1.2	1.1
Patch foraging time to switch 0 sec	1.1	4.3	9.1	-1.5	-1.1	2.1	3.0
Patch foraging water rate 0 sec	0.3	1.0	2.2	0.7	0.5	-1.0	-1.5
Patch foraging water rate 12 sec	0.9	3.6	6.6	1.6	1.2	-1.9	-2.6
Patch foraging water rate 18 sec	0.6	1.4	2.8	0.9	0.7	-1.2	-1.7
Patch foraging water rate 24 sec	0.9	1.2	2.0	1.0	0.8	-1.2	-1.4
Patch foraging water rate 6 sec	5.9	8.7	9.3	3.1	3.0	-3.0	-2.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.9	-0.1	-0.3	-0.3	-0.9
Distance traveled before self-admin	1.3	2.8	6.6	1.1	0.8	-1.7	-2.6
Distance traveled after self-admin	0.3	0.5	1.1	-0.8	-1.0	0.4	-0.4
Extensor digitorum longus weight	0.2	0.9	1.4	1.1	1.2	-0.9	-0.5
Bone: elastic displacement	0.3	0.4	0.7	-0.7	-0.9	0.6	0.3
Bone: elastic work	0.5	0.6	0.9	0.7	0.6	-0.8	-1.0
Bone: endosteal estimation	2.8	6.8	8.1	2.8	2.9	-2.6	-2.1
Bone: endosteal perimeter	1.7	4.2	4.7	2.2	2.2	-2.1	-1.7
Epididymis fat weight	0.1	0.3	0.9	0.2	0.5	0.2	0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	-0.3	0.3	0.2
Delta time in open arm before/after self-admin	1.4	1.7	2.3	1.2	1.1	-1.4	-1.5
Diff in mean of infusions in LGA sessions	0.1	0.2	0.6	-0.0	-0.2	-0.2	-0.8
Delay discount exponential model param	0.2	0.2	0.3	0.5	0.5	-0.5	-0.4
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.3	-0.4	0.2	0.1
Active lever presses in extinction session 6	0.3	0.3	1.0	-0.1	0.2	0.3	1.0
Bone: final force	2.4	3.9	4.1	2.0	2.0	-2.0	-1.8
Bone: final moment	3.0	4.8	5.1	2.2	2.2	-2.3	-2.1
Food consumed during 24 hour testing period	1.2	2.5	2.7	1.6	1.6	-1.6	-1.5
Glucose	1.7	2.7	3.6	-1.8	-1.9	1.6	1.2
Heart weight	1.4	2.2	3.0	1.6	1.7	-1.4	-1.0
Delay discount hyperbolic model param	0.2	0.3	0.4	0.6	0.6	-0.6	-0.4
Intermittent access intake day 1-15 change	0.2	1.0	1.2	1.1	1.1	-1.0	-0.9
Intermittent access intake escalation	0.3	1.7	2.0	1.4	1.4	-1.3	-1.0
Intermittent access intake escalation 2	0.1	0.2	0.5	0.3	0.2	-0.5	-0.7
Intermitt. access day 1 inactive lever presses	0.2	2.1	2.8	1.6	1.7	-1.4	-0.9
Intermitt. access day 15 inactive lever presses	0.7	3.6	4.8	2.1	2.2	-1.9	-1.2
Intermitt. access escalation Index	0.2	0.5	0.6	-0.7	-0.7	0.7	0.7
Intermittent access day 1 total infusions	0.2	0.6	0.9	0.9	0.9	-0.8	-0.5
Intermittent access day 15 total infusions	0.6	1.4	2.0	1.3	1.4	-1.1	-0.7
Intermittent access terminal intake (last 3 days)	0.7	1.2	1.6	1.2	1.3	-1.1	-0.8
Intermittent access total infusions	1.5	1.8	2.3	1.5	1.5	-1.3	-0.9
Intermittent access day 1 locomotion	0.8	1.5	1.8	1.3	1.3	-1.2	-1.0
Intermittent access day 15 total locomotion	0.5	2.1	3.0	1.3	1.2	-1.5	-1.7
Intermittent access total locomotion	3.3	4.0	4.2	2.0	2.0	-2.0	-1.9
Intermittent access standard deviation	0.0	0.2	0.3	-0.5	-0.5	0.5	0.3
Left kidney weight	3.2	25.5	28.1	5.3	5.3	-5.1	-4.5
Right kidney weight	3.6	25.0	29.1	5.4	5.4	-5.0	-4.1
Cocaine induced anxiety	0.4	1.2	1.3	1.1	1.1	-1.1	-1.0
Post-drug Anxiety	0.5	0.5	0.9	0.9	0.9	-0.7	-0.3
Baseline Anxiety	0.4	0.7	0.9	-0.8	-0.8	0.9	1.0
Tail length	2.5	13.2	14.7	3.8	3.8	-3.7	-3.2
Length with tail	3.1	13.7	16.7	4.0	4.1	-3.7	-3.0
Length without tail	0.9	4.7	7.2	2.4	2.7	-2.0	-1.2
Times rat made contact with spout	0.1	0.1	0.2	-0.2	-0.1	0.3	0.5
Lifetime Intake	1.0	1.2	1.6	1.2	1.3	-1.1	-0.7
Liver weight, left	1.1	1.8	2.1	1.4	1.4	-1.3	-1.2
Liver weight, right	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0
Locomotor activity	0.1	0.1	0.3	-0.2	-0.2	0.4	0.6
Locomotor testing distance	0.0	0.1	0.2	0.3	0.4	-0.0	0.4
Locomotor testing rearing	0.2	0.7	1.0	1.0	1.0	-0.8	-0.6
Locomotion in novel chamber	1.3	1.7	2.3	-1.5	-1.4	1.3	0.9
Locomotion in novel chamber post-restriction	0.3	0.9	1.2	-0.9	-0.8	1.0	1.1
Fecal boli incidents, locomotor time 1	0.1	0.4	0.5	0.6	0.5	-0.6	-0.7
Change in fecal boli incidents, locomotor task	2.9	3.1	3.5	-1.9	-1.9	1.7	1.5
Time >=10cm from walls, locomotor time 1	0.0	0.1	0.2	-0.1	-0.1	0.2	0.4
Bouts of movement, locomotor time 1	0.4	0.6	1.6	0.3	0.1	-0.7	-1.3
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.1	-0.3	-0.2	-0.6
Rest time, locomotor task time 1	1.0	1.6	1.9	1.4	1.3	-1.3	-1.0
Distance moved, locomotor task time 1	0.6	1.8	2.1	-1.4	-1.4	1.4	1.1
Vertical activity count, locomotor time 1	0.5	3.4	5.0	-2.2	-2.2	1.8	0.9
Time >=10cm from walls, locomotor time 2	0.4	1.0	1.5	-0.9	-0.9	1.0	1.2
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.2	0.1	-0.1	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.2	0.1	-0.2	-0.2
Rest time, locomotor task time 2	0.0	0.1	0.2	0.0	-0.1	-0.2	-0.5
Distance moved, locomotor task time 2	0.1	0.2	0.2	-0.5	-0.5	0.5	0.4
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.5	-0.6	0.4	0.1
Light reinforcement 1	0.1	0.3	0.4	-0.5	-0.7	0.1	-0.6
Light reinforcement 2	0.9	2.1	2.9	-1.7	-1.6	1.4	0.9
Bone: marrow area	2.8	6.8	8.2	2.8	2.9	-2.6	-2.1
Bone: maximum diameter	1.0	2.0	2.7	1.6	1.6	-1.4	-1.0
Bone: maximum force	3.0	5.9	6.7	2.6	2.6	-2.5	-2.1
Bone: maximum moment	3.6	6.8	7.4	2.7	2.7	-2.7	-2.3
Mean time between licks in bursts	0.1	0.7	1.3	-1.0	-1.1	0.8	0.4
Mean num. licks in bursts	0.1	0.1	0.3	0.4	0.5	-0.3	-0.1
Cd content in liver	2.3	2.6	2.7	1.6	1.5	-1.6	-1.6
Co content in liver	0.9	1.0	2.3	0.7	0.6	-1.1	-1.5
Cu content in liver	0.9	1.1	1.3	1.0	1.1	-1.1	-0.9
Fe content in liver	0.3	0.3	0.4	0.5	0.6	-0.6	-0.5
K content in liver	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0
Mg content in liver	0.1	0.1	0.4	-0.2	-0.1	0.4	0.6
Mn content in liver	0.0	0.1	0.2	-0.1	0.1	0.2	0.4
Na content in liver	3.1	3.5	4.0	-2.0	-1.9	1.9	1.7
Rb content in liver	2.6	3.0	3.9	1.9	2.0	-1.7	-1.3
Se content in liver	2.3	2.7	3.6	-1.6	-1.4	1.7	1.9
Sr content in liver	6.0	5.2	7.2	-2.6	-2.7	2.2	1.3
Zn content in liver	0.5	0.6	1.5	-0.6	-0.3	0.8	1.2
Bone: minimum diameter	3.4	6.4	7.1	2.7	2.6	-2.6	-2.3
Time in familiar zone, hab. session 1	3.3	3.6	5.1	1.7	1.5	-2.0	-2.3
Time in novel zone, hab. session 1	2.6	2.9	3.1	-1.7	-1.6	1.8	1.7
Total zone transitions, hab. session 1	0.8	1.1	2.8	0.6	0.2	-1.0	-1.7
Total locomotion distance, hab. session 1	0.3	0.4	1.2	0.2	-0.1	-0.5	-1.1
Locomotion velocity, hab. session 1	0.2	0.3	0.9	0.2	-0.1	-0.4	-0.9
Time in familiar zone, hab. session 2	3.0	3.3	4.6	2.0	2.1	-1.8	-1.2
Time in novel zone, hab. session 2	2.0	2.2	2.7	-1.6	-1.6	1.5	1.2
Total zone transitions, hab. session 2	2.2	2.9	4.3	1.6	1.3	-1.7	-2.1
Total locomotion distance, hab. session 2	0.1	0.1	0.4	0.0	-0.2	-0.2	-0.6
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.2	-0.4	-0.1	-0.6
Novel to familiar place preference ratio	0.0	0.0	0.0	0.2	0.2	-0.1	-0.0
Novelty place preference	0.1	0.1	0.2	0.4	0.4	-0.3	-0.3
Time in novel zone, NPP test	0.1	0.2	0.2	0.4	0.5	-0.4	-0.3
Total zone transitions, NPP test	0.3	0.4	0.9	0.6	0.3	-0.6	-1.0
Total locomotion distance, NPP test	0.3	0.4	0.5	0.7	0.6	-0.6	-0.6
Locomotion velocity, NPP test	0.3	0.5	0.7	0.7	0.5	-0.7	-0.8
Intraocular pressure	0.0	0.0	0.1	-0.3	-0.3	0.2	-0.0
Delta distance traveled before/after self-admin	2.3	2.5	2.7	-1.6	-1.5	1.7	1.6
Delta ambulatory time before/after self-admin	1.1	1.9	2.0	-1.4	-1.4	1.4	1.3
Parametrial fat weight	1.8	4.2	4.5	-2.0	-2.0	2.1	2.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	-0.4	0.3	0.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	-0.8	-0.7	1.0	1.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.3	-0.5	-0.6	0.5	0.4
Pavlov. Cond. index score	0.3	0.3	0.4	-0.5	-0.5	0.6	0.6
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.4	-0.4	0.5	0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.5	0.5	-0.3	-0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.5	0.4	-0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.4	-0.6	0.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	-0.6	-0.5	0.6	0.6
Pavlov. Cond. response bias	0.0	0.1	0.2	0.0	0.1	0.2	0.4
Pavlov. Cond. lever latency	0.3	0.4	0.4	0.6	0.6	-0.6	-0.6
Pavlov. Cond. magazine entry latency	0.7	1.0	1.2	-1.0	-0.9	1.0	1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.3	0.2	-0.4	-0.5
Pavlov. Cond. index score	0.0	0.1	0.1	-0.2	-0.2	0.3	0.3
Pavlov. Cond. latency score	0.3	0.5	0.5	-0.7	-0.6	0.7	0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3
Pavlov. Cond. magazine entry number	0.4	0.6	0.6	0.8	0.7	-0.8	-0.8
Pavlov. Cond. intertrial magazine entries	2.2	4.8	5.0	2.2	2.2	-2.2	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.4	-0.4	0.4	0.4
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	0.4	-0.3	-0.2
Time in closed arm before self-admin	0.6	1.0	1.1	1.0	1.0	-1.0	-1.0
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	0.4	-0.2	0.0
Time in open arm before self-admin	2.1	2.6	2.6	-1.6	-1.6	1.6	1.6
Time in open arm after self-admin	0.2	0.2	0.3	-0.6	-0.6	0.3	0.1
Bone: periosteal estimation	2.1	5.0	5.7	2.4	2.4	-2.3	-1.9
Bone: periosteal perimeter	1.7	3.3	3.5	1.9	1.9	-1.9	-1.7
Bone: post-yield work	2.8	4.8	6.5	2.4	2.5	-2.2	-1.5
Progressive ratio test 1 active lever presses	0.5	0.9	1.4	0.8	0.7	-1.0	-1.2
Progressive ratio test 1 breakpoint	0.5	0.9	1.3	0.8	0.7	-1.0	-1.2
Progressive ratio test 1 inactive lever presses	1.5	3.9	4.2	2.0	1.9	-2.1	-1.9
Progressive ratio test 2 active lever presses	0.5	0.7	1.1	0.9	1.0	-0.8	-0.3
Progressive ratio test 2 breakpoint	0.6	0.8	1.3	1.0	1.1	-0.8	-0.4
Progressive ratio test 2 inactive lever presses	1.5	4.7	5.1	2.3	2.2	-2.2	-2.0
Incentive Sensitization - Responses	0.7	1.9	3.1	1.6	1.7	-1.3	-0.7
Incentive Sensitization - Breakpoint	0.6	1.3	2.2	1.3	1.5	-1.0	-0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.2
Progressive ratio	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.3
Food seeking constrained by brief footshock	1.1	1.3	4.2	-0.3	-0.8	-0.5	-2.1
Seeking ratio, punishment vs. effort	0.3	0.7	1.6	0.6	0.5	-0.9	-1.3
Retroperitoneal fat weight	4.2	18.6	23.1	-4.1	-3.8	4.5	4.8
Reaction time number correct	0.0	0.2	0.3	-0.4	-0.6	0.4	0.3
Reaction time mean minus median	0.0	0.0	0.0	0.0	0.0	-0.0	-0.1
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	0.0	0.1	0.2
Reaction time num false alarms	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1
Reaction time num false alarms AUC	0.1	0.2	0.4	-0.7	-0.6	0.3	0.2
Reaction time trials correct on left	0.0	0.2	0.3	-0.4	-0.6	0.4	0.3
Reaction time trials on left	0.0	0.2	0.3	-0.4	-0.6	0.4	0.2
Reaction time mean	0.4	0.9	1.4	1.0	1.2	-0.9	-0.6
Reaction time mean AUC	0.1	0.3	0.6	0.6	0.8	-0.5	-0.2
Median of all reaction times	0.5	0.8	1.3	1.0	1.2	-0.9	-0.5
Reaction time omissions	0.1	0.1	0.2	-0.3	-0.4	0.1	-0.3
Reaction time false alarm rate	0.0	0.1	0.1	-0.4	-0.3	0.1	0.0
Reaction time premature initiation rate	0.0	0.0	0.1	0.2	0.2	-0.1	0.0
Reaction time premature initiations	0.0	0.0	0.1	-0.1	-0.1	0.2	0.3
Std. dev. reaction times	0.2	0.6	0.9	0.8	1.0	-0.8	-0.5
Reaction time trials completed	0.0	0.2	0.3	-0.4	-0.6	0.4	0.2
Reaction time trials AUC	0.0	0.1	0.2	-0.3	-0.4	0.4	0.3
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.6	0.8	-0.5	-0.1
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.1	0.1	-0.1	0.0
Latency to leave start box in cocaine runway	0.5	0.7	0.7	0.9	0.8	-0.8	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2
Latency to leave start box in cocaine runway, M	1.6	1.5	1.7	1.3	1.3	-1.2	-1.1
Std. dev. time between licks in bursts	0.2	0.3	0.7	-0.5	-0.9	0.2	-0.5
Total sessions with >9 infusions	1.0	1.2	1.5	1.0	1.0	-1.1	-1.2
Short access day 1 total inactive lever presses	0.5	0.9	1.5	1.1	1.2	-0.9	-0.5
Short access day 10 total inactive lever presses	0.0	0.2	0.3	0.5	0.5	-0.5	-0.4
Short access day 1 total infusions	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0
Short access total infusions	0.0	0.0	0.0	-0.2	-0.2	0.2	0.2
Short access day 1 locomotion	0.3	0.4	0.6	0.7	0.8	-0.6	-0.4
Short access day 10 total locomotion	0.3	1.2	2.5	0.8	0.6	-1.1	-1.6
Short access total locomotion	0.3	0.5	1.4	0.3	0.1	-0.6	-1.2
One hour access (0.3 mA shock)	4.3	5.1	5.9	2.4	2.4	-2.3	-1.9
Compulsive drug intake	1.6	2.4	2.7	1.6	1.6	-1.6	-1.4
One hour access (shock baseline)	0.2	0.4	0.7	0.8	0.9	-0.5	-0.0
Social response proportion	0.7	0.9	1.5	1.1	1.2	-0.9	-0.4
Social responses	3.0	3.9	4.5	2.1	2.1	-2.0	-1.7
Social time	3.0	4.8	6.4	2.1	1.8	-2.3	-2.5
Soleus weight	0.0	0.1	0.2	0.4	0.4	-0.3	-0.2
Bone: stiffness	2.6	4.7	5.2	2.2	2.3	-2.2	-1.9
Tibialis anterior weight	0.8	2.6	3.9	-1.4	-1.3	1.7	2.0
Time to tail flick, vehicle, before self-admin	0.4	0.5	0.9	0.6	0.4	-0.7	-1.0
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.7	0.8	0.8	-0.6	-0.2
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.5	-0.7	0.1	-0.6
Time to tail flick, test, after self-admin	0.3	0.3	0.6	-0.4	-0.4	0.5	0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	-0.1	0.0	0.3	0.6
Delta time to tail flick, test, before/after SA	0.1	0.2	0.3	0.4	0.5	-0.1	0.5
Tibia length	3.8	10.5	12.3	3.5	3.5	-3.2	-2.6
Ambulatory time before self-admin	0.8	2.3	5.0	1.1	0.9	-1.5	-2.2
Ambulatory time after self-admin	0.2	0.4	1.2	-0.2	-0.4	-0.2	-1.1
Bone: tissue strength	0.3	0.3	0.8	0.3	0.0	-0.5	-0.9
Total heroin consumption	0.0	0.0	0.1	-0.2	-0.2	0.1	0.0
Bone: trabecular number	0.1	0.2	0.3	-0.5	-0.5	0.4	0.2
Bone: trabecular spacing	0.0	0.0	0.0	0.1	0.1	0.0	0.2
Bone: trabecular thickness	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1
Bone: trabecular tissue density	0.6	1.1	1.7	-0.9	-0.7	1.1	1.3
Water consumed over 24 hours	0.6	1.3	1.7	1.1	0.9	-1.2	-1.3
Number of responses in last shaping day	0.0	0.0	0.1	0.1	0.2	0.0	0.3