Tmem121

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Tmem121 0.29 0.13 0.0e+00 0.33 0.32 0.33 0.33 2.5e-31 1.9e-30 3.6e-31 1.7e-31
2 NAcc mRNA stability Tmem121 0.05 0.04 1.5e-07 0.04 0.06 0.04 0.05 1.8e-05 1.4e-07 5.0e-06 2.1e-06
3 pVTA intron excision ratio chr6_132262243_132264265 0.07 0.06 1.3e-03 0.02 0.04 -0 0.02 6.0e-02 5.2e-03 4.3e-01 5.2e-02
4 Adipose gene expression Tmem121 0.12 0.07 0.0e+00 0.14 0.15 0.14 0.14 3.0e-15 6.4e-16 8.1e-15 5.2e-15
5 BLA mRNA stability Tmem121 0.25 0.12 3.9e-13 0.19 0.22 0.21 0.21 2.2e-10 5.3e-12 1.3e-11 1.5e-11
6 NAcc gene expression Tmem121 0.03 0.02 8.8e-04 0.03 0.03 0.01 0.03 4.4e-04 3.6e-04 1.8e-02 4.4e-04
7 PL mRNA stability Tmem121 0.23 0.1 0.0e+00 0.31 0.3 0.31 0.31 8.3e-35 5.2e-33 1.5e-34 1.8e-34
8 IL mRNA stability Tmem121 0.2 0.14 6.5e-05 0.2 0.14 0.13 0.16 1.7e-05 3.5e-04 5.1e-04 1.2e-04
9 BLA gene expression Tmem121 0.06 0.05 8.9e-03 0.04 0.03 0.05 0.03 5.6e-03 8.6e-03 1.4e-03 7.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.10.10.10.10.10.10.2-0.3-0.1-0.3
Area under the delay curve1.31.41.9-1.4-1.2-1.2-1.2-1.2-1.31.01.3-0.1
BMI with tail1.44.67.7-2.0-1.8-1.9-1.8-1.7-2.42.62.02.8
BMI without tail0.71.52.3-1.1-1.1-1.2-1.1-1.1-1.41.51.11.2
Body weight1.77.39.32.93.03.03.03.12.6-2.4-2.80.2
Weight adjusted by age0.10.20.30.30.50.50.50.60.3-0.3-0.30.3
Bone surface0.30.60.9-0.7-0.9-0.9-0.9-0.9-0.70.70.9-0.0
Bone volume0.30.50.8-0.6-0.8-0.8-0.8-0.9-0.60.60.8-0.2
Breakpoint value in progressive ratio session0.00.00.10.20.20.20.20.20.2-0.00.20.3
Number of licking bursts1.21.41.7-1.3-1.2-1.2-1.2-1.2-1.21.11.30.3
Context. condit. distance diff. score2.83.44.31.91.81.81.81.82.1-2.1-2.0-1.0
Locomotion velocity, session 10.40.40.80.40.70.70.70.90.3-0.6-0.30.6
Locomotion distance, session 10.10.20.8-0.5-0.1-0.1-0.10.1-0.50.20.50.9
Locomotion velocity, session 20.30.41.0-0.6-0.3-0.3-0.3-0.1-0.80.60.91.0
Locomotion distance, session 20.60.91.3-1.0-0.8-0.8-0.8-0.7-1.11.21.11.0
Locomotion velocity, session 30.10.10.5-0.10.00.00.00.2-0.2-0.10.70.1
Locomotion distance, session 30.10.10.3-0.3-0.1-0.0-0.00.1-0.40.10.60.4
Stereotopy head waving bouts, day 30.00.10.10.30.20.20.20.20.3-0.1-0.1-0.3
Stereotopy head waving duration, day 30.10.10.30.30.10.10.10.10.3-0.2-0.1-0.6
Locomotion velocity, session 70.10.10.30.40.20.20.10.10.4-0.3-0.3-0.6
Locomotion distance, session 70.70.91.2-1.1-1.0-1.0-1.0-1.0-1.00.91.10.2
Stereotopy head waving bouts, day 72.42.73.31.81.61.61.61.61.8-1.8-1.5-1.4
Stereotopy head waving duration, day 71.61.92.41.51.31.31.31.31.6-1.5-1.3-1.3
Locomotion velocity, session 82.22.73.31.81.71.71.71.71.8-1.5-1.8-0.3
Locomotion distance, session 80.40.50.70.70.80.80.80.80.8-0.8-0.7-0.1
Degree of sensitization distance0.30.30.5-0.4-0.6-0.6-0.6-0.7-0.40.50.2-0.2
Degree of sensitization stereotypy1.01.11.41.21.01.01.01.01.2-1.2-1.0-1.0
Conditioned locomotion1.72.02.51.41.61.61.61.61.4-1.4-1.4-0.4
Cocaine response after cond. corrected0.10.10.40.00.30.30.40.40.1-0.1-0.10.6
Cocaine response after cond. not corrected0.30.31.6-0.5-0.0-0.1-0.00.1-0.60.50.31.3
Cocaine response before conditioning2.02.43.3-1.5-1.5-1.5-1.5-1.5-1.81.81.41.2
Saline control response0.00.10.10.20.30.30.20.40.2-0.40.10.0
Bone: connectivity density0.30.50.60.80.80.80.80.80.8-0.8-0.7-0.3
Bone: cortical apparent density3.54.65.92.22.22.22.22.22.2-2.4-2.3-0.9
Bone: cortical area0.20.31.80.3-0.0-0.0-0.0-0.10.6-0.6-0.1-1.3
Bone: cortical porosity0.10.10.40.40.20.30.20.20.5-0.3-0.5-0.7
Bone: cortical porosity0.20.20.30.60.40.40.40.30.5-0.3-0.6-0.4
Bone: cortical thickness0.60.91.60.80.80.80.80.71.2-1.3-0.9-1.2
Bone: cortical thickness0.40.51.10.50.50.50.50.50.8-1.0-0.5-1.0
Bone: cortical tissue density3.44.55.72.12.22.22.22.22.2-2.4-2.3-0.8
Condit. Reinf. active minus inactive responses0.10.10.3-0.6-0.3-0.3-0.3-0.3-0.50.20.50.2
Condit. Reinf. active-inactive response ratio1.11.21.6-1.3-1.1-1.1-1.1-1.1-1.31.11.10.4
Condit. Reinf. active responses0.20.20.40.20.60.60.60.70.2-0.5-0.30.3
Condit. Reinf. inactive responses2.22.63.91.51.81.81.92.01.6-1.7-1.4-0.1
Incentive salience index mean0.10.10.30.10.40.40.40.50.1-0.3-0.20.3
Condit. Reinf. lever presses0.40.50.70.60.80.80.80.80.6-0.6-0.80.2
Condit. Reinf. active minus inactive responses0.40.40.70.70.80.80.80.90.5-0.6-0.50.3
Condit. Reinf. active-inactive response ratio0.00.00.10.20.20.20.20.20.3-0.1-0.10.1
Condit. Reinf. active responses0.10.10.50.10.20.20.20.3-0.1-0.00.00.7
Condit. Reinf. inactive responses0.20.20.8-0.5-0.3-0.3-0.3-0.2-0.70.30.30.9
Condit. Reinf. lever presses1.92.63.2-1.7-1.6-1.6-1.6-1.6-1.81.71.70.9
Condit. Reinf. lever reinforcers received0.00.10.40.10.20.20.20.3-0.1-0.10.00.6
Conditioned reinforcement - actives0.70.71.10.80.90.90.90.90.9-1.1-0.7-0.7
Conditioned reinforcement - inactives0.50.61.00.50.90.90.91.00.5-0.8-0.6-0.8
Conditioned locomotion0.00.00.2-0.00.00.00.00.0-0.1-0.1-0.5-0.2
Patch foraging indifference point 0 sec6.710.813.23.63.63.53.53.63.3-3.4-3.1-1.4
Patch foraging indifference point AUC8.19.312.33.23.43.43.43.52.9-2.9-3.0-0.3
Delay disc. indifference point, 0s delay0.30.40.50.50.70.70.70.70.6-0.7-0.6-0.1
Delay disc. indifference point, 16s delay1.41.52.5-1.6-1.3-1.3-1.2-1.2-1.41.11.1-0.1
Delay disc. indifference point, 2s delay4.34.86.7-2.2-2.3-2.3-2.3-2.3-2.22.12.60.5
Delay disc. indifference point, 24s delay1.11.01.6-1.2-1.0-1.0-1.0-0.9-1.31.01.10.6
Delay disc. indifference point, 4s delay0.50.51.0-0.8-0.7-0.7-0.7-0.6-0.80.61.0-0.5
Delay disc. indifference point, 8s delay0.40.40.7-0.8-0.6-0.6-0.6-0.6-0.80.60.8-0.0
Indifference point function ln k0.20.20.60.50.30.30.30.30.6-0.6-0.5-0.8
Indifference point function log k0.20.20.60.50.30.30.30.30.6-0.6-0.5-0.8
Patch foraging total patch changes 0 sec8.113.015.93.93.93.93.94.03.7-3.7-3.4-1.4
Patch foraging total patch changes 12 sec4.25.47.72.42.62.62.62.82.2-2.4-1.9-0.7
Patch foraging total patch changes 18 sec3.24.15.62.22.22.22.22.41.9-2.1-1.7-0.7
Patch foraging total patch changes 24 sec1.82.23.01.71.71.61.61.71.4-1.3-1.3-0.4
Patch foraging total patch changes 6 sec7.711.515.73.73.83.83.84.03.3-3.3-3.1-0.4
Patch foraging time to switch 0 sec11.617.921.0-4.5-4.6-4.6-4.6-4.6-4.44.24.31.1
Patch foraging water rate 0 sec15.725.129.05.45.45.45.45.45.3-5.2-5.0-1.5
Patch foraging water rate 12 sec4.57.08.92.72.92.92.93.02.5-2.6-2.70.2
Patch foraging water rate 18 sec3.14.25.42.32.32.32.32.32.1-1.8-2.0-0.0
Patch foraging water rate 24 sec2.53.55.01.92.22.12.22.21.7-1.5-1.80.9
Patch foraging water rate 6 sec3.65.26.32.42.52.52.52.52.4-2.2-2.4-0.0
Seeking ratio, delayed vs. immediate footshock0.40.50.60.70.70.70.70.70.6-0.6-0.5-0.8
Distance traveled before self-admin0.70.81.5-1.1-0.7-0.7-0.7-0.6-1.10.90.61.2
Distance traveled after self-admin0.00.00.20.10.10.10.10.00.2-0.3-0.00.4
Extensor digitorum longus weight8.935.141.76.36.06.16.05.96.5-6.4-6.1-3.4
Bone: elastic displacement0.10.20.3-0.4-0.5-0.5-0.5-0.6-0.20.10.1-0.5
Bone: elastic work1.11.42.0-1.2-1.3-1.3-1.3-1.4-1.11.01.00.0
Bone: endosteal estimation1.73.74.9-1.8-2.2-2.2-2.2-2.2-1.81.92.1-0.2
Bone: endosteal perimeter0.30.71.1-0.6-0.9-0.9-0.9-0.9-0.60.81.0-0.4
Epididymis fat weight1.43.24.5-1.8-1.8-1.8-1.8-1.8-2.02.11.71.0
Delta time in closed arm before/after self-admin0.30.31.30.40.40.40.40.50.30.1-0.31.2
Delta time in open arm before/after self-admin0.90.81.50.90.90.90.90.81.1-1.2-1.0-0.2
Diff in mean of infusions in LGA sessions1.01.11.81.11.01.11.11.11.0-0.9-0.6-1.3
Delay discount exponential model param1.01.11.61.21.11.01.01.01.2-0.9-1.30.2
Extinction: sum of active levers before priming0.10.11.20.0-0.1-0.1-0.1-0.10.0-0.1-0.1-1.1
Active lever presses in extinction session 61.51.52.51.11.11.11.11.11.2-1.2-1.4-1.6
Bone: final force0.60.91.6-0.6-1.1-1.1-1.1-1.2-0.40.60.8-1.2
Bone: final moment0.40.71.8-0.4-0.9-0.9-1.0-1.1-0.10.40.6-1.4
Food consumed during 24 hour testing period0.91.11.51.11.21.21.21.21.0-1.0-0.9-0.3
Glucose0.10.10.8-0.1-0.3-0.2-0.3-0.30.0-0.20.3-0.9
Heart weight0.30.51.2-0.4-0.7-0.7-0.7-0.8-0.40.60.7-1.1
Delay discount hyperbolic model param1.41.42.31.41.21.21.21.21.4-1.0-1.50.2
Intermittent access intake day 1-15 change1.21.21.6-1.3-1.1-1.1-1.1-1.0-1.31.11.20.4
Intermittent access intake escalation1.21.11.5-1.2-1.1-1.1-1.1-1.1-1.21.11.10.2
Intermittent access intake escalation 20.30.20.5-0.5-0.5-0.5-0.5-0.5-0.30.30.7-0.6
Intermitt. access day 1 inactive lever presses3.13.34.31.72.02.02.02.11.7-2.1-1.9-0.8
Intermitt. access day 15 inactive lever presses0.40.50.80.50.60.70.70.70.6-0.9-0.6-0.8
Intermitt. access escalation Index0.00.00.10.00.10.10.10.2-0.0-0.20.40.3
Intermittent access day 1 total infusions0.20.20.70.30.40.40.40.50.3-0.3-0.8-0.0
Intermittent access day 15 total infusions0.60.61.0-1.0-0.8-0.8-0.8-0.8-1.00.90.30.4
Intermittent access terminal intake (last 3 days)0.90.91.4-1.2-1.0-1.0-1.0-0.9-1.21.10.80.0
Intermittent access total infusions0.00.00.1-0.2-0.1-0.1-0.1-0.1-0.20.2-0.4-0.2
Intermittent access day 1 locomotion0.00.00.1-0.10.00.00.00.0-0.10.1-0.40.3
Intermittent access day 15 total locomotion0.10.10.3-0.2-0.1-0.1-0.1-0.0-0.20.3-0.50.1
Intermittent access total locomotion0.10.10.30.30.30.30.30.40.2-0.1-0.5-0.1
Intermittent access standard deviation0.20.20.5-0.7-0.2-0.2-0.2-0.1-0.70.40.00.7
Left kidney weight2.77.69.13.02.92.92.92.83.0-2.7-3.0-0.5
Right kidney weight1.33.54.32.12.02.02.01.92.1-1.7-2.0-0.7
Cocaine induced anxiety0.20.20.40.50.40.40.40.40.6-0.6-0.4-0.6
Post-drug Anxiety0.20.30.40.60.60.60.50.60.6-0.4-0.2-0.5
Baseline Anxiety0.50.50.8-0.8-0.7-0.7-0.6-0.6-0.80.90.90.6
Tail length4.714.216.04.03.93.93.93.84.0-3.9-3.9-2.5
Length with tail9.033.037.06.06.16.16.16.06.0-5.9-6.0-2.6
Length without tail6.013.115.43.73.93.93.93.93.7-3.7-3.8-0.9
Times rat made contact with spout0.30.40.80.50.80.80.80.90.4-0.6-0.30.3
Lifetime Intake0.10.10.1-0.4-0.3-0.3-0.3-0.3-0.40.3-0.2-0.3
Liver weight, left2.53.94.82.12.22.12.12.12.1-1.9-2.2-0.1
Liver weight, right0.91.52.61.11.51.51.51.60.9-1.0-1.00.7
Locomotor activity0.10.10.20.30.40.40.40.40.4-0.3-0.40.1
Locomotor testing distance0.00.10.10.20.30.30.30.30.3-0.3-0.3-0.0
Locomotor testing rearing1.62.53.6-1.8-1.5-1.5-1.5-1.3-1.81.51.91.5
Locomotion in novel chamber2.32.83.11.81.71.71.71.71.7-1.7-1.6-1.2
Locomotion in novel chamber post-restriction0.20.30.5-0.3-0.6-0.6-0.6-0.6-0.50.70.5-0.0
Fecal boli incidents, locomotor time 10.10.10.6-0.2-0.3-0.3-0.3-0.3-0.30.80.2-0.4
Change in fecal boli incidents, locomotor task1.41.31.81.21.31.31.31.31.1-1.2-1.00.0
Time >=10cm from walls, locomotor time 13.83.95.42.02.22.22.22.31.8-1.6-2.30.2
Bouts of movement, locomotor time 11.01.11.3-1.1-1.1-1.1-1.1-1.1-1.10.81.2-0.5
Total resting periods, locomotor time 11.21.41.7-1.2-1.3-1.3-1.3-1.3-1.20.91.1-0.7
Rest time, locomotor task time 10.40.40.6-0.7-0.6-0.6-0.6-0.5-0.80.70.7-0.6
Distance moved, locomotor task time 11.31.53.2-1.1-1.2-1.2-1.2-1.3-1.01.10.71.8
Vertical activity count, locomotor time 10.30.32.1-0.4-0.4-0.4-0.3-0.4-0.30.40.21.4
Time >=10cm from walls, locomotor time 22.83.03.61.91.91.91.81.91.8-1.7-1.7-0.5
Bouts of movement, locomotor time 21.11.18.7-0.3-0.6-0.5-0.6-0.6-0.2-0.00.4-2.9
Total resting periods, locomotor time 20.80.95.6-0.5-0.7-0.6-0.6-0.6-0.30.10.5-2.4
Rest time, locomotor task time 20.00.10.2-0.4-0.2-0.2-0.1-0.1-0.40.2-0.1-0.1
Distance moved, locomotor task time 20.60.61.7-0.6-0.8-0.8-0.8-0.8-0.60.60.81.3
Vertical activity count, locomotor time 20.10.10.20.20.10.20.10.10.3-0.2-0.2-0.5
Light reinforcement 10.00.00.30.10.10.10.10.10.10.1-0.10.5
Light reinforcement 21.01.41.9-1.2-1.3-1.3-1.2-1.4-1.21.30.80.8
Bone: marrow area1.73.74.9-1.8-2.2-2.2-2.2-2.2-1.81.82.0-0.2
Bone: maximum diameter0.30.50.7-0.6-0.8-0.8-0.8-0.8-0.50.40.8-0.5
Bone: maximum force0.20.31.2-0.1-0.6-0.6-0.6-0.70.00.20.3-1.1
Bone: maximum moment0.20.31.50.2-0.4-0.4-0.4-0.50.30.00.1-1.2
Mean time between licks in bursts0.50.70.9-1.0-0.8-0.8-0.8-0.8-0.90.90.80.5
Mean num. licks in bursts1.72.02.51.51.61.61.61.61.4-1.4-1.4-0.2
Cd content in liver0.50.60.80.70.80.80.90.90.6-0.8-0.70.1
Co content in liver0.91.01.80.91.11.11.11.11.0-1.3-0.9-0.4
Cu content in liver2.32.83.4-1.7-1.7-1.7-1.7-1.7-1.81.81.80.9
Fe content in liver1.21.42.0-1.1-1.3-1.3-1.4-1.4-1.01.31.1-0.1
K content in liver1.41.41.91.01.31.31.41.31.0-0.9-1.40.8
Mg content in liver0.20.20.50.40.50.50.50.50.4-0.2-0.70.5
Mn content in liver0.10.20.60.40.10.10.1-0.00.5-0.2-0.6-0.8
Na content in liver0.00.00.1-0.00.10.10.10.10.1-0.0-0.30.3
Rb content in liver0.10.20.30.30.50.50.50.50.4-0.5-0.2-0.0
Se content in liver0.10.10.5-0.10.10.10.20.2-0.20.1-0.00.7
Sr content in liver0.10.10.3-0.6-0.2-0.2-0.1-0.0-0.40.10.60.5
Zn content in liver0.10.10.2-0.4-0.2-0.2-0.2-0.2-0.20.00.4-0.1
Bone: minimum diameter0.30.62.10.80.40.40.40.30.9-0.7-0.5-1.4
Time in familiar zone, hab. session 10.10.10.6-0.2-0.3-0.2-0.3-0.30.0-0.00.3-0.8
Time in novel zone, hab. session 10.80.71.2-0.9-0.7-0.7-0.7-0.7-1.01.00.81.1
Total zone transitions, hab. session 10.70.91.3-0.9-1.1-1.1-1.1-1.1-0.91.01.00.1
Total locomotion distance, hab. session 10.00.10.10.0-0.3-0.3-0.3-0.3-0.00.20.1-0.3
Locomotion velocity, hab. session 10.20.20.40.60.40.40.40.30.6-0.5-0.6-0.5
Time in familiar zone, hab. session 20.60.60.80.70.90.90.90.90.8-0.6-0.80.3
Time in novel zone, hab. session 21.11.11.4-1.0-1.1-1.1-1.1-1.1-1.10.91.20.1
Total zone transitions, hab. session 20.10.20.7-0.4-0.1-0.1-0.1-0.0-0.50.20.50.8
Total locomotion distance, hab. session 20.20.20.40.40.50.50.50.60.4-0.5-0.20.1
Locomotion velocity, hab. session 20.20.30.50.60.60.60.60.70.6-0.7-0.4-0.2
Novel to familiar place preference ratio0.80.81.3-1.1-1.0-1.0-1.0-1.0-1.00.51.0-0.2
Novelty place preference1.01.01.5-1.2-1.1-1.1-1.1-1.1-1.10.61.1-0.2
Time in novel zone, NPP test0.40.40.7-0.8-0.7-0.7-0.7-0.6-0.70.30.7-0.2
Total zone transitions, NPP test0.81.22.20.81.31.31.31.50.7-1.0-0.70.8
Total locomotion distance, NPP test0.50.61.00.80.90.90.91.00.6-0.8-0.70.3
Locomotion velocity, NPP test0.20.30.40.50.60.60.60.70.4-0.6-0.50.1
Intraocular pressure0.30.50.6-0.7-0.8-0.8-0.8-0.7-0.70.40.7-0.4
Delta distance traveled before/after self-admin0.20.20.60.60.30.30.20.10.7-0.70.2-0.8
Delta ambulatory time before/after self-admin0.60.71.31.00.60.60.60.51.1-1.1-0.3-1.1
Parametrial fat weight0.10.20.3-0.4-0.4-0.4-0.4-0.3-0.50.50.50.4
Pavlov. Cond. lever latency0.10.10.5-0.1-0.3-0.3-0.3-0.40.10.00.2-0.7
Pavlov. Cond. magazine entry latency0.20.21.00.0-0.4-0.3-0.4-0.50.10.1-0.2-1.0
Pavlov. Cond. change in total contacts0.00.00.10.20.20.20.20.20.2-0.2-0.30.0
Pavlov. Cond. index score0.00.00.10.0-0.0-0.0-0.0-0.10.00.0-0.2-0.2
Pavlov. Cond. latency score0.00.00.00.0-0.0-0.00.0-0.00.0-0.0-0.2-0.1
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.3-0.3-0.3-0.3-0.50.40.20.5
Pavlov. Cond. magazine entry number0.10.10.4-0.20.00.00.00.1-0.30.00.40.6
Pavlov. Cond. intertrial magazine entries7.99.511.83.13.33.33.33.43.2-3.4-3.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.0-0.1-0.1-0.1-0.10.0-0.0-0.2-0.3
Pavlov. Cond. response bias0.10.10.20.30.20.20.20.20.3-0.1-0.4-0.2
Pavlov. Cond. lever latency3.04.15.02.22.02.02.02.02.2-2.1-2.1-1.2
Pavlov. Cond. magazine entry latency3.13.65.1-2.1-1.7-1.7-1.7-1.5-2.22.02.31.8
Pavlov. Cond. change in total contacts5.98.210.3-3.0-3.0-3.0-3.0-2.9-3.03.03.21.1
Pavlov. Cond. index score4.35.57.1-2.6-2.3-2.3-2.2-2.1-2.72.52.71.7
Pavlov. Cond. latency score3.74.66.1-2.4-2.0-2.0-2.0-1.8-2.52.32.41.8
Pavlov. Cond. lever contacts3.14.25.5-2.3-2.0-2.0-2.0-1.9-2.32.22.21.4
Pavlov. Cond. magazine entry number2.93.65.72.11.71.71.71.52.2-1.9-2.4-1.6
Pavlov. Cond. intertrial magazine entries4.35.67.32.52.52.52.52.42.4-2.5-2.7-1.0
Pavlov. Cond. lever-magazine prob. diff.4.96.38.1-2.8-2.4-2.4-2.4-2.3-2.82.62.81.8
Pavlov. Cond. response bias3.24.45.7-2.3-2.0-2.0-2.0-1.9-2.42.32.31.6
Time in closed arm before self-admin7.88.810.7-3.3-3.1-3.1-3.1-3.1-3.23.02.81.8
Time in closed arm after self-admin6.97.19.0-2.8-2.7-2.7-2.7-2.6-2.83.02.42.1
Time in open arm before self-admin5.96.48.12.72.82.82.82.82.5-2.6-2.1-1.1
Time in open arm after self-admin10.211.312.73.53.53.53.53.43.6-3.5-3.3-2.1
Bone: periosteal estimation0.71.52.2-1.0-1.4-1.4-1.4-1.5-0.80.81.3-1.0
Bone: periosteal perimeter0.10.10.4-0.1-0.4-0.4-0.4-0.4-0.00.10.4-0.7
Bone: post-yield work1.72.33.41.81.41.41.41.31.8-1.5-1.4-1.4
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.2-0.2-0.2-0.2-0.30.1-0.2-0.2
Progressive ratio test 1 breakpoint0.10.10.2-0.4-0.3-0.3-0.3-0.3-0.40.2-0.1-0.1
Progressive ratio test 1 inactive lever presses1.92.12.71.51.51.51.41.51.4-1.7-1.4-1.2
Progressive ratio test 2 active lever presses0.00.00.1-0.2-0.1-0.1-0.1-0.0-0.20.3-0.10.0
Progressive ratio test 2 breakpoint0.00.00.1-0.10.00.00.00.1-0.10.2-0.30.1
Progressive ratio test 2 inactive lever presses0.10.10.6-0.00.10.10.10.2-0.1-0.2-0.2-0.8
Incentive Sensitization - Responses0.10.20.3-0.4-0.3-0.3-0.3-0.2-0.40.60.50.4
Incentive Sensitization - Breakpoint0.10.10.2-0.4-0.3-0.3-0.3-0.2-0.40.50.40.3
Sum of active levers in priming session hrs 5-60.20.20.2-0.5-0.4-0.4-0.4-0.4-0.40.40.50.3
Progressive ratio1.92.12.6-1.5-1.6-1.6-1.6-1.6-1.41.61.2-1.1
Food seeking constrained by brief footshock0.20.21.70.2-0.2-0.1-0.2-0.20.1-0.20.0-1.3
Seeking ratio, punishment vs. effort1.01.21.91.31.21.11.11.11.2-1.4-0.90.0
Retroperitoneal fat weight0.00.00.1-0.2-0.2-0.2-0.2-0.1-0.30.10.3-0.3
Reaction time number correct3.75.36.82.52.32.32.32.32.5-2.6-2.3-1.1
Reaction time mean minus median0.00.00.1-0.3-0.1-0.1-0.1-0.1-0.30.1-0.10.4
Reaction time mean minus median AUC0.00.00.1-0.3-0.2-0.2-0.2-0.2-0.2-0.0-0.10.0
Reaction time num false alarms1.82.52.91.71.61.61.61.51.7-1.7-1.7-0.9
Reaction time num false alarms AUC1.92.63.31.81.61.61.61.51.8-1.7-1.8-1.0
Reaction time trials correct on left3.75.36.82.52.32.32.32.32.5-2.6-2.3-1.1
Reaction time trials on left3.75.36.72.52.32.32.32.32.5-2.6-2.3-1.1
Reaction time mean2.12.93.8-1.9-1.8-1.8-1.8-1.8-1.81.71.40.9
Reaction time mean AUC1.31.72.4-1.6-1.4-1.4-1.4-1.4-1.41.31.00.7
Median of all reaction times1.92.73.4-1.8-1.8-1.8-1.8-1.8-1.71.71.30.7
Reaction time omissions0.70.91.41.01.01.01.01.01.0-1.0-1.2-0.5
Reaction time false alarm rate0.10.20.30.50.40.40.40.40.4-0.4-0.6-0.5
Reaction time premature initiation rate0.10.20.50.40.30.30.30.30.4-0.7-0.4-0.2
Reaction time premature initiations1.82.64.01.71.61.61.61.61.8-2.0-1.7-0.7
Std. dev. reaction times1.31.82.5-1.6-1.5-1.5-1.4-1.5-1.51.31.00.4
Reaction time trials completed3.75.36.72.52.32.32.32.32.5-2.6-2.3-1.1
Reaction time trials AUC3.85.56.92.52.42.42.42.32.6-2.6-2.4-1.0
Run reversals in cocaine runway, females3.13.04.3-1.8-2.0-2.0-2.0-2.1-1.71.61.3-0.1
Run reversals in cocaine runway, males0.10.10.5-0.2-0.2-0.2-0.2-0.2-0.20.30.60.7
Latency to leave start box in cocaine runway1.01.12.3-1.1-1.1-1.1-1.1-1.0-1.10.81.50.3
Latency to leave start box in cocaine runway, F0.20.30.4-0.5-0.5-0.5-0.5-0.5-0.50.60.30.6
Latency to leave start box in cocaine runway, M1.21.24.6-1.1-1.0-1.0-1.0-1.0-0.90.42.1-0.3
Std. dev. time between licks in bursts0.10.10.20.30.20.20.20.20.3-0.40.0-0.4
Total sessions with >9 infusions0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.20.1-0.3-0.2
Short access day 1 total inactive lever presses0.00.00.1-0.20.0-0.0-0.00.0-0.30.3-0.30.1
Short access day 10 total inactive lever presses0.20.20.30.30.50.50.50.60.2-0.5-0.5-0.2
Short access day 1 total infusions0.00.00.2-0.1-0.1-0.1-0.1-0.1-0.10.2-0.3-0.4
Short access day 10 total infusions0.20.20.3-0.5-0.5-0.5-0.5-0.4-0.60.5-0.00.4
Short access total infusions0.60.70.9-0.9-1.0-1.0-1.0-0.9-0.90.90.50.1
Short access day 1 locomotion0.30.30.5-0.7-0.6-0.6-0.6-0.5-0.70.70.20.3
Short access day 10 total locomotion0.00.00.10.10.20.20.20.3-0.0-0.1-0.00.1
Short access total locomotion0.10.10.2-0.10.00.00.00.1-0.20.3-0.40.5
One hour access (0.3 mA shock)0.70.81.00.80.90.91.01.00.8-0.9-1.0-0.6
Compulsive drug intake0.70.71.00.91.01.01.01.00.9-0.7-0.60.1
One hour access (shock baseline)0.10.20.5-0.4-0.4-0.4-0.4-0.3-0.40.0-0.0-0.7
Social response proportion0.50.61.0-0.7-0.8-0.8-0.8-0.8-0.71.00.40.8
Social responses0.50.60.8-0.8-0.9-0.9-0.9-0.8-0.80.80.90.3
Social time0.10.10.2-0.2-0.4-0.4-0.4-0.5-0.20.20.0-0.2
Soleus weight2.36.77.82.62.72.82.82.82.7-2.8-2.5-1.3
Bone: stiffness0.71.11.61.20.90.90.90.91.3-1.2-0.8-1.3
Tibialis anterior weight0.93.14.51.71.81.81.81.91.9-2.1-1.5-1.1
Time to tail flick, vehicle, before self-admin2.93.04.21.62.01.92.02.11.5-2.0-1.5-0.5
Time to tail flick, vehicle, after self-admin1.01.11.41.11.21.21.21.21.0-1.1-0.80.7
Time to tail flick, test, before self-admin0.50.53.2-0.4-0.4-0.4-0.4-0.4-0.30.20.6-1.8
Time to tail flick, test, after self-admin5.25.36.42.52.52.52.52.52.4-2.3-2.30.5
Delta time to tail flick, vehicle, before/after SA0.10.10.30.50.20.20.10.00.6-0.4-0.30.4
Delta time to tail flick, test, before/after SA5.75.16.12.42.52.42.52.52.2-2.0-2.41.2
Tibia length0.10.30.50.70.50.50.50.40.5-0.4-0.6-0.1
Ambulatory time before self-admin1.01.01.8-1.1-0.7-0.8-0.7-0.6-1.21.11.21.3
Ambulatory time after self-admin0.40.41.4-0.5-0.5-0.5-0.5-0.5-0.40.40.91.2
Bone: tissue strength0.50.50.9-0.4-0.8-0.8-0.9-0.9-0.50.80.5-0.3
Total heroin consumption2.53.03.71.81.91.91.91.91.8-1.6-1.6-0.9
Bone: trabecular number0.20.40.60.60.60.60.60.60.6-0.8-0.5-0.3
Bone: trabecular spacing0.10.10.2-0.2-0.4-0.4-0.4-0.5-0.20.1-0.0-0.2
Bone: trabecular thickness0.10.10.20.20.40.40.40.40.2-0.2-0.30.4
Bone: trabecular tissue density0.00.00.0-0.0-0.1-0.1-0.1-0.20.1-0.0-0.2-0.0
Water consumed over 24 hours1.01.11.51.21.21.21.21.21.1-1.0-0.9-0.4
Number of responses in last shaping day0.60.60.8-0.9-0.9-0.9-0.9-0.9-0.90.90.60.2