Hub : Genes

Tmeff2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Tmeff2 0.03 0.02 1.2e-03 0.02 0.02 0.02 0.02 1.1e-03 6.3e-03 5.0e-03 1.3e-03
2 IC gene expression Tmeff2 0.09 0.07 5.3e-03 0.02 0.03 0.02 0.02 6.6e-02 1.9e-02 4.1e-02 6.0e-02
3 IL gene expression Tmeff2 0.24 0.13 4.0e-03 0.05 0.06 0.04 0.06 2.3e-02 1.8e-02 4.1e-02 1.8e-02
4 Brain gene expression Tmeff2 0.1 0.06 2.2e-08 0.06 0.07 0.06 0.06 5.8e-06 3.6e-07 1.0e-06 1.4e-06
5 Brain mRNA stability Tmeff2 0.42 0.13 0.0e+00 0.22 0.25 0.24 0.25 1.7e-20 4.4e-23 2.1e-22 1.4e-23
6 IL mRNA stability Tmeff2 0.25 0.13 1.2e-04 0.04 0.14 0.09 0.12 3.8e-02 2.7e-04 3.4e-03 1.1e-03
7 Liver gene expression Tmeff2 0.16 0.13 5.8e-04 0.04 0.02 0.04 0.04 2.4e-05 4.7e-03 9.4e-06 2.6e-05
8 PL gene expression Tmeff2 0.27 0.15 3.2e-06 0.03 0.05 0.05 0.03 6.7e-04 5.4e-06 4.5e-06 3.4e-04
9 OFC mRNA stability Tmeff2 0.45 0.15 2.1e-08 0.19 0.27 0.29 0.26 3.3e-05 4.9e-07 1.2e-07 7.8e-07
10 pVTA mRNA stability Tmeff2 0.09 0.06 7.2e-06 0.07 0.07 0.07 0.06 2.5e-06 3.7e-06 5.3e-06 8.7e-06
11 PL mRNA stability Tmeff2 0.09 0.05 4.7e-07 0.06 0.05 0.04 0.04 8.3e-07 2.4e-06 9.6e-06 2.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.33.01.71.51.61.61.30.40.11.20.3-0.4-0.2
Area under the delay curve1.92.26.8-1.3-1.3-1.3-1.2-1.8-1.7-2.6-0.7-1.1-1.2-1.2
BMI with tail2.58.616.0-3.7-3.9-4.0-4.0-3.4-2.2-1.8-3.5-1.2-0.5-0.4
BMI without tail0.41.32.2-1.2-1.3-1.4-1.4-1.2-1.3-0.5-1.5-0.9-0.8-0.8
Body weight0.41.94.11.72.01.91.81.60.61.51.20.2-0.2-0.2
Weight adjusted by age0.60.91.61.31.21.00.90.5-0.51.00.9-0.8-1.2-0.9
Bone surface0.81.43.51.81.31.51.51.20.2-0.91.90.4-0.4-0.2
Bone volume1.01.74.82.21.71.81.81.40.2-0.21.40.1-0.6-0.5
Breakpoint value in progressive ratio session0.30.30.80.70.90.70.70.4-0.00.10.4-0.4-0.6-0.5
Number of licking bursts0.10.10.9-0.1-0.1-0.1-0.0-0.40.2-0.3-0.90.3-0.00.1
Context. condit. distance diff. score1.92.34.0-1.6-1.9-2.0-2.0-2.0-1.3-1.0-1.4-1.3-0.7-0.7
Locomotion velocity, session 11.31.42.9-1.1-1.5-1.6-1.7-1.5-1.00.2-1.3-0.9-0.3-0.4
Locomotion distance, session 10.91.22.5-0.9-1.3-1.4-1.6-1.5-1.10.5-0.8-1.1-0.3-0.4
Locomotion velocity, session 21.82.04.9-1.9-2.2-2.1-2.2-1.5-0.7-0.6-1.1-0.30.30.4
Locomotion distance, session 20.20.31.3-0.3-0.4-0.3-0.5-0.20.21.10.80.00.60.6
Locomotion velocity, session 32.02.36.6-0.4-0.10.40.61.22.2-0.80.72.62.32.3
Locomotion distance, session 30.40.41.0-0.20.10.30.30.71.00.20.51.00.91.0
Stereotopy head waving bouts, day 31.01.23.4-0.6-0.5-0.10.00.21.5-0.60.41.71.81.7
Stereotopy head waving duration, day 30.80.92.8-0.1-0.10.20.30.61.40.10.51.51.71.5
Locomotion velocity, session 72.62.95.5-1.8-1.9-2.2-2.1-2.1-1.4-0.9-2.3-1.2-0.8-0.8
Locomotion distance, session 71.01.32.2-1.4-1.2-1.3-1.5-1.4-1.2-0.1-0.7-1.2-0.8-0.7
Stereotopy head waving bouts, day 70.30.40.90.20.20.30.50.61.00.1-0.21.00.90.8
Stereotopy head waving duration, day 70.70.92.10.40.30.30.50.91.40.4-1.01.51.21.2
Locomotion velocity, session 81.41.72.9-0.7-1.4-1.6-1.7-1.7-1.4-0.1-1.3-1.6-0.7-1.0
Locomotion distance, session 82.02.95.8-1.6-2.1-2.2-2.4-2.4-1.7-0.3-1.2-1.7-0.8-0.8
Degree of sensitization distance1.11.12.6-0.3-0.5-0.8-0.9-1.2-1.50.3-0.9-1.6-1.3-1.4
Degree of sensitization stereotypy0.10.10.10.30.20.20.30.30.3-0.4-0.20.30.20.2
Conditioned locomotion3.03.56.61.82.52.62.52.11.61.72.11.10.60.7
Cocaine response after cond. corrected0.50.61.20.91.10.90.80.5-0.41.00.5-0.8-0.8-0.8
Cocaine response after cond. not corrected0.70.82.51.21.31.11.01.00.31.60.1-0.1-0.3-0.3
Cocaine response before conditioning0.50.61.6-0.0-0.1-0.20.00.51.10.4-1.11.31.01.0
Saline control response0.10.10.4-0.5-0.3-0.4-0.3-0.30.1-0.3-0.60.20.30.2
Bone: connectivity density0.20.41.50.90.50.70.60.5-0.2-0.41.2-0.1-0.5-0.3
Bone: cortical apparent density5.27.116.9-4.1-3.8-3.7-3.7-3.1-1.2-1.4-2.3-0.70.40.5
Bone: cortical area0.20.31.50.00.30.50.40.50.50.11.20.30.60.6
Bone: cortical porosity3.33.57.52.12.42.72.72.01.2-0.52.61.10.20.0
Bone: cortical porosity4.34.610.02.62.83.13.22.41.4-0.62.81.40.0-0.0
Bone: cortical thickness0.50.72.5-1.6-1.1-0.8-0.9-0.60.1-0.50.80.10.90.8
Bone: cortical thickness0.20.20.5-0.6-0.6-0.6-0.6-0.7-0.4-0.1-0.5-0.4-0.0-0.1
Bone: cortical tissue density5.06.916.7-4.1-3.7-3.6-3.6-3.0-1.2-1.4-2.3-0.70.40.5
Condit. Reinf. active minus inactive responses2.93.25.92.42.02.12.42.12.10.50.42.01.01.1
Condit. Reinf. active-inactive response ratio2.02.13.71.91.61.71.81.71.70.90.31.60.80.9
Condit. Reinf. active responses1.41.74.72.21.71.71.91.41.20.00.21.00.10.3
Condit. Reinf. inactive responses0.30.30.8-0.1-0.2-0.2-0.2-0.7-0.7-0.8-0.2-0.7-0.9-0.6
Incentive salience index mean1.21.44.72.21.61.71.81.10.7-0.40.30.7-0.3-0.1
Condit. Reinf. lever presses0.50.71.90.90.40.40.4-0.2-1.0-1.20.1-0.9-1.4-1.2
Condit. Reinf. active minus inactive responses2.12.76.82.42.62.52.41.50.60.91.30.2-0.6-0.6
Condit. Reinf. active-inactive response ratio1.61.85.02.22.12.02.01.10.40.30.50.2-0.7-0.7
Condit. Reinf. active responses0.60.92.21.21.51.21.10.4-0.20.70.8-0.7-0.9-0.9
Condit. Reinf. inactive responses0.81.12.1-1.1-0.9-1.2-1.2-1.3-1.2-0.1-0.6-1.4-0.8-0.9
Condit. Reinf. lever presses0.50.73.1-0.6-0.4-0.4-0.4-1.0-0.9-1.80.1-0.7-0.8-0.9
Condit. Reinf. lever reinforcers received0.60.91.91.11.41.11.00.2-0.40.40.8-0.8-1.1-1.1
Conditioned reinforcement - actives0.50.92.5-0.7-0.5-0.3-0.10.51.3-0.50.01.51.41.6
Conditioned reinforcement - inactives1.82.67.0-0.9-0.20.10.51.12.5-0.9-0.02.62.42.6
Conditioned locomotion0.91.12.8-1.7-1.3-1.1-0.9-0.30.8-0.8-0.71.01.11.4
Patch foraging indifference point 0 sec3.66.714.6-1.0-1.9-1.9-2.3-3.3-3.8-2.40.2-3.4-3.0-2.9
Patch foraging indifference point AUC0.20.20.7-0.2-0.3-0.4-0.5-0.4-0.80.2-0.2-0.8-0.5-0.6
Delay disc. indifference point, 0s delay2.52.75.1-1.4-1.8-1.8-1.7-2.1-1.6-2.2-1.8-0.9-1.2-0.9
Delay disc. indifference point, 16s delay1.21.44.9-0.9-1.0-1.0-0.8-1.4-1.2-2.2-0.9-0.7-1.1-0.9
Delay disc. indifference point, 2s delay1.31.42.8-0.6-0.6-0.7-0.7-1.3-1.7-1.4-0.3-1.5-1.6-1.5
Delay disc. indifference point, 24s delay0.40.52.8-0.7-0.7-0.6-0.4-0.50.0-1.7-0.70.50.20.3
Delay disc. indifference point, 4s delay1.51.62.7-1.5-1.6-1.6-1.4-1.6-0.9-1.6-1.5-0.4-0.3-0.3
Delay disc. indifference point, 8s delay1.31.53.5-0.3-0.4-0.4-0.4-1.2-1.7-1.9-0.2-1.4-1.6-1.7
Indifference point function ln k1.11.93.5-0.6-1.1-1.1-1.2-1.8-1.9-1.4-0.7-1.5-1.6-1.4
Indifference point function log k1.11.93.5-0.6-1.1-1.1-1.2-1.8-1.9-1.4-0.7-1.5-1.6-1.4
Patch foraging total patch changes 0 sec3.36.313.5-1.1-1.9-1.9-2.2-3.2-3.7-2.40.1-3.3-2.8-2.7
Patch foraging total patch changes 12 sec0.81.02.3-0.5-0.6-0.6-0.8-1.3-1.5-0.70.5-1.4-1.2-1.1
Patch foraging total patch changes 18 sec1.72.64.9-1.8-2.1-2.1-2.2-2.2-1.7-1.0-0.6-1.4-0.7-0.6
Patch foraging total patch changes 24 sec0.50.81.5-0.5-0.7-0.5-0.7-1.0-1.2-1.11.2-1.0-0.8-0.7
Patch foraging total patch changes 6 sec2.94.49.4-1.0-1.8-1.8-2.0-2.7-3.1-2.00.1-2.6-2.3-2.1
Patch foraging time to switch 0 sec1.42.86.10.31.01.11.21.82.52.00.52.02.22.2
Patch foraging water rate 0 sec0.71.53.3-0.2-0.7-0.8-0.9-1.4-1.8-1.30.0-1.6-1.7-1.5
Patch foraging water rate 12 sec1.02.24.90.0-0.7-0.9-1.1-1.7-2.2-0.1-0.2-2.2-2.2-2.0
Patch foraging water rate 18 sec0.20.41.00.50.30.10.0-0.3-0.70.1-0.1-0.9-1.0-1.0
Patch foraging water rate 24 sec0.10.20.80.70.60.40.30.30.10.9-0.2-0.2-0.4-0.3
Patch foraging water rate 6 sec0.91.22.5-0.7-0.9-0.9-0.9-1.5-1.6-1.30.2-1.3-1.0-1.3
Seeking ratio, delayed vs. immediate footshock1.62.03.51.71.81.81.71.91.21.51.10.80.60.5
Distance traveled before self-admin1.62.04.92.22.12.02.21.61.20.3-0.10.9-0.00.1
Distance traveled after self-admin0.40.51.80.60.40.20.4-0.4-0.4-1.0-1.3-0.4-0.9-0.9
Extensor digitorum longus weight1.76.915.7-4.0-3.7-3.6-3.6-3.2-1.3-1.8-2.0-0.50.50.4
Bone: elastic displacement0.10.10.30.10.50.50.50.30.40.10.30.30.20.2
Bone: elastic work1.01.42.81.51.71.71.71.20.80.51.30.50.10.1
Bone: endosteal estimation1.94.112.03.52.92.82.82.20.60.81.20.3-0.9-0.7
Bone: endosteal perimeter1.22.66.12.52.32.22.31.91.00.61.00.8-0.10.0
Epididymis fat weight0.20.82.01.31.20.91.01.10.31.4-0.7-0.0-0.0-0.4
Delta time in closed arm before/after self-admin0.30.31.50.2-0.10.30.30.30.2-1.01.20.60.20.4
Delta time in open arm before/after self-admin4.04.08.72.92.72.62.42.20.82.51.70.2-0.2-0.3
Diff in mean of infusions in LGA sessions0.20.20.70.50.50.40.50.1-0.1-0.8-0.4-0.1-0.6-0.4
Delay discount exponential model param1.61.85.51.11.21.11.11.61.62.40.61.11.21.2
Extinction: sum of active levers before priming0.30.30.8-0.10.50.50.60.50.9-0.20.00.70.40.6
Active lever presses in extinction session 60.60.61.50.80.90.80.70.1-0.6-0.10.4-0.9-1.2-1.1
Bone: final force1.93.05.32.32.12.32.32.31.40.71.91.20.60.6
Bone: final moment1.42.34.02.01.81.91.92.01.20.71.70.90.50.5
Food consumed during 24 hour testing period0.20.31.7-0.5-0.7-0.8-0.6-0.10.1-0.4-1.30.40.10.1
Glucose0.50.81.9-1.4-0.8-0.7-0.7-0.10.80.2-0.71.01.21.3
Heart weight0.30.51.90.40.30.0-0.1-0.2-1.00.5-0.1-1.4-1.1-1.1
Delay discount hyperbolic model param1.71.95.91.21.21.11.11.61.62.40.51.11.21.2
Intermittent access intake day 1-15 change0.30.61.2-1.1-1.1-1.0-1.0-0.8-0.5-0.8-0.3-0.2-0.10.1
Intermittent access intake escalation0.40.81.9-1.4-1.3-1.2-1.1-0.9-0.4-1.0-0.3-0.00.10.3
Intermittent access intake escalation 20.40.41.0-0.6-0.7-0.7-0.6-0.7-0.8-1.0-0.0-0.5-0.6-0.5
Intermitt. access day 1 inactive lever presses0.93.48.6-2.9-2.4-2.0-1.8-0.90.9-1.7-1.21.52.02.0
Intermitt. access day 15 inactive lever presses0.61.32.9-1.7-1.4-1.4-1.2-1.2-0.4-1.6-1.30.00.10.1
Intermitt. access escalation Index0.20.33.30.10.30.0-0.10.20.21.80.0-0.20.30.2
Intermittent access day 1 total infusions0.30.40.80.20.50.70.60.70.8-0.10.90.70.50.7
Intermittent access day 15 total infusions0.81.22.9-1.5-1.0-0.7-0.60.11.1-0.90.51.41.51.7
Intermittent access terminal intake (last 3 days)0.81.12.3-1.5-1.3-0.8-0.8-0.20.6-1.50.61.01.01.3
Intermittent access total infusions0.81.02.4-0.4-0.10.20.30.81.4-0.41.21.41.41.5
Intermittent access day 1 locomotion0.10.10.4-0.6-0.4-0.3-0.4-0.40.0-0.1-0.2-0.1-0.10.1
Intermittent access day 15 total locomotion0.40.71.8-1.3-1.1-1.1-1.0-1.0-0.4-1.2-0.4-0.2-0.30.0
Intermittent access total locomotion0.81.02.8-1.7-1.3-1.2-1.2-1.2-0.3-1.4-0.5-0.1-0.20.2
Intermittent access standard deviation0.51.02.8-1.7-1.3-1.1-1.0-0.60.4-1.2-0.50.70.80.9
Left kidney weight0.10.30.70.70.90.60.60.5-0.10.6-0.6-0.4-0.3-0.6
Right kidney weight0.31.33.5-0.0-0.2-0.5-0.6-0.8-1.8-0.3-1.0-1.8-1.6-1.9
Cocaine induced anxiety0.20.30.8-0.4-0.3-0.4-0.5-0.5-0.9-0.40.1-0.8-0.6-0.7
Post-drug Anxiety0.30.30.5-0.7-0.5-0.7-0.7-0.7-0.30.3-0.7-0.4-0.2-0.1
Baseline Anxiety0.40.51.50.70.60.50.60.60.91.2-0.40.60.50.5
Tail length5.621.739.46.06.26.36.15.83.13.65.21.80.80.5
Length with tail5.925.847.46.56.96.86.66.13.64.65.21.90.90.7
Length without tail2.16.613.13.43.63.53.42.91.82.82.10.80.20.3
Times rat made contact with spout1.82.05.9-0.60.10.40.71.32.1-0.70.42.42.02.1
Lifetime Intake0.50.61.7-0.6-0.3-0.0-0.00.51.0-0.10.81.01.11.3
Liver weight, left2.74.56.92.12.32.42.52.62.41.71.81.91.71.6
Liver weight, right1.52.75.31.42.12.01.91.81.62.31.20.91.00.8
Locomotor activity0.60.94.7-0.5-0.8-0.8-0.6-1.1-0.7-2.2-1.0-0.1-0.6-0.6
Locomotor testing distance1.12.03.3-0.3-0.7-1.0-0.9-1.6-1.8-1.4-1.7-1.4-1.8-1.8
Locomotor testing rearing0.51.02.6-0.6-0.7-1.0-0.9-1.0-1.2-0.9-1.6-1.0-0.8-1.1
Locomotion in novel chamber2.73.58.5-1.3-1.3-1.9-1.9-2.1-1.91.0-2.9-2.2-1.6-1.6
Locomotion in novel chamber post-restriction0.20.31.2-0.4-0.3-0.1-0.10.30.80.2-0.00.90.81.1
Fecal boli incidents, locomotor time 13.44.912.30.5-0.4-0.5-0.8-1.9-3.5-1.60.5-3.3-3.5-3.3
Change in fecal boli incidents, locomotor task0.30.31.50.60.50.30.20.40.11.2-0.7-0.20.1-0.2
Time >=10cm from walls, locomotor time 10.50.51.10.80.60.60.40.1-0.80.20.8-0.9-1.1-1.0
Bouts of movement, locomotor time 11.51.74.4-0.3-0.5-0.6-0.9-1.4-2.1-0.60.8-2.1-1.8-1.7
Total resting periods, locomotor time 11.82.04.5-0.7-1.0-1.1-1.3-1.7-2.1-0.80.3-2.0-1.7-1.5
Rest time, locomotor task time 10.30.31.7-0.2-0.6-0.4-0.3-0.6-0.7-1.30.4-0.2-0.6-0.3
Distance moved, locomotor task time 10.40.61.20.81.00.90.81.00.30.91.1-0.10.1-0.1
Vertical activity count, locomotor time 10.10.31.2-0.50.10.00.10.50.90.4-0.40.71.10.8
Time >=10cm from walls, locomotor time 21.42.05.42.31.91.71.50.9-0.41.50.8-0.9-1.2-1.3
Bouts of movement, locomotor time 21.52.54.2-2.0-1.8-1.9-2.1-2.0-1.7-0.5-0.8-1.7-0.7-1.0
Total resting periods, locomotor time 21.62.84.9-2.2-2.0-2.1-2.2-2.1-1.8-0.6-0.7-1.8-0.8-0.9
Rest time, locomotor task time 20.30.30.9-0.9-0.8-0.6-0.6-0.30.3-0.1-0.00.50.50.8
Distance moved, locomotor task time 20.50.61.11.00.90.70.50.3-0.50.90.6-1.0-0.7-1.0
Vertical activity count, locomotor time 20.10.21.1-0.6-0.4-0.5-0.4-0.30.00.2-1.0-0.00.40.1
Light reinforcement 10.82.07.2-2.7-2.0-1.6-1.6-1.3-0.1-1.5-0.10.30.90.9
Light reinforcement 20.30.52.0-0.30.10.40.50.00.3-1.41.40.70.50.4
Bone: marrow area1.83.811.23.32.82.72.82.10.60.81.20.3-0.9-0.7
Bone: maximum diameter0.20.40.80.90.80.80.80.70.30.30.70.10.10.1
Bone: maximum force2.23.87.62.82.52.62.52.41.31.32.30.80.30.3
Bone: maximum moment1.62.85.72.42.22.22.12.01.01.32.10.50.20.2
Mean time between licks in bursts0.41.04.4-2.1-1.2-1.2-1.3-1.1-0.3-0.1-0.1-0.30.40.4
Mean num. licks in bursts0.30.41.2-0.5-0.20.10.20.70.6-0.81.10.80.80.7
Cd content in liver0.30.40.80.50.70.70.90.80.80.0-0.00.70.30.4
Co content in liver0.50.63.0-0.2-0.4-0.2-0.2-0.9-0.9-1.70.5-0.6-0.9-0.7
Cu content in liver0.50.62.91.71.00.90.90.80.10.8-0.10.1-0.5-0.3
Fe content in liver1.11.32.10.80.91.21.41.31.2-0.91.41.50.80.8
K content in liver0.50.52.90.0-0.10.30.20.2-0.4-1.41.70.0-0.20.1
Mg content in liver0.20.20.60.50.20.40.40.70.1-0.20.70.20.10.3
Mn content in liver1.41.53.1-1.8-1.6-1.6-1.5-1.5-0.4-1.3-1.4-0.00.10.3
Na content in liver1.01.12.70.5-0.00.0-0.0-0.2-1.5-1.60.6-1.2-1.6-1.6
Rb content in liver0.10.10.4-0.6-0.5-0.4-0.5-0.3-0.10.1-0.1-0.10.30.3
Se content in liver0.00.10.30.2-0.2-0.1-0.0-0.20.2-0.50.10.3-0.10.3
Sr content in liver0.30.32.00.00.30.50.50.30.3-0.51.40.40.10.4
Zn content in liver0.10.10.60.80.40.50.50.30.1-0.10.30.2-0.30.1
Bone: minimum diameter0.61.02.11.41.31.31.41.50.70.30.90.60.20.1
Time in familiar zone, hab. session 10.60.51.8-1.3-0.9-0.9-0.9-0.9-0.3-0.6-0.7-0.30.2-0.1
Time in novel zone, hab. session 11.61.65.12.31.81.61.71.40.30.60.70.1-0.8-0.5
Total zone transitions, hab. session 10.10.20.5-0.4-0.1-0.2-0.1-0.6-0.6-0.7-0.3-0.5-0.5-0.6
Total locomotion distance, hab. session 10.20.30.70.80.90.70.70.2-0.10.20.6-0.3-0.6-0.5
Locomotion velocity, hab. session 10.20.31.50.50.80.80.70.40.20.11.20.1-0.1-0.1
Time in familiar zone, hab. session 20.60.62.1-0.20.2-0.2-0.2-0.6-0.80.5-1.4-1.1-0.9-1.2
Time in novel zone, hab. session 21.11.13.00.40.30.60.61.11.3-0.01.71.31.11.4
Total zone transitions, hab. session 20.00.10.3-0.3-0.2-0.1-0.2-0.1-0.10.20.6-0.10.30.1
Total locomotion distance, hab. session 20.70.91.20.80.91.00.91.11.10.81.10.90.80.8
Locomotion velocity, hab. session 20.40.50.80.60.60.70.70.80.90.80.80.70.60.6
Novel to familiar place preference ratio4.75.28.31.92.52.82.82.92.31.42.81.91.41.4
Novelty place preference4.95.28.21.72.42.72.72.92.51.32.92.11.61.7
Time in novel zone, NPP test5.76.29.71.82.62.92.93.12.71.43.12.41.81.9
Total zone transitions, NPP test0.20.40.8-0.7-0.7-0.7-0.9-0.8-0.60.30.1-0.7-0.2-0.2
Total locomotion distance, NPP test0.20.20.50.70.40.30.20.0-0.30.70.6-0.5-0.5-0.4
Locomotion velocity, NPP test0.10.10.30.3-0.0-0.1-0.2-0.4-0.50.30.2-0.5-0.5-0.4
Intraocular pressure1.01.42.9-1.2-1.3-1.6-1.7-1.1-0.61.3-1.7-0.90.0-0.2
Delta distance traveled before/after self-admin0.70.81.6-1.2-1.1-1.2-1.3-1.1-0.70.1-0.8-0.7-0.1-0.3
Delta ambulatory time before/after self-admin1.31.62.5-1.2-1.2-1.4-1.5-1.6-1.5-0.5-0.9-1.4-0.9-1.1
Parametrial fat weight0.10.20.6-0.2-0.5-0.5-0.60.00.20.8-0.60.20.50.5
Pavlov. Cond. lever latency1.21.65.4-1.2-0.8-0.6-0.50.51.50.10.51.62.32.0
Pavlov. Cond. magazine entry latency1.51.94.81.91.30.90.70.0-1.31.2-0.6-1.5-2.2-1.9
Pavlov. Cond. change in total contacts0.90.92.51.20.70.40.2-0.0-1.01.0-0.1-1.3-1.6-1.3
Pavlov. Cond. index score1.41.85.21.71.20.80.6-0.2-1.40.9-0.4-1.7-2.3-1.9
Pavlov. Cond. latency score1.82.37.01.81.20.80.6-0.4-1.70.8-0.5-2.0-2.6-2.3
Pavlov. Cond. lever contacts1.11.34.51.10.80.50.4-0.5-1.30.3-0.4-1.5-2.1-1.7
Pavlov. Cond. magazine entry number1.41.75.1-2.3-1.6-1.3-1.1-0.70.5-1.70.20.81.61.2
Pavlov. Cond. intertrial magazine entries2.12.65.60.40.91.31.41.72.4-0.31.02.32.22.0
Pavlov. Cond. lever-magazine prob. diff.1.31.74.81.51.10.70.5-0.2-1.40.9-0.4-1.7-2.2-1.9
Pavlov. Cond. response bias1.01.33.21.71.20.90.70.2-0.91.1-0.1-1.1-1.8-1.4
Pavlov. Cond. lever latency0.40.61.20.30.50.60.60.91.01.10.20.71.00.9
Pavlov. Cond. magazine entry latency0.30.40.9-0.6-0.6-0.4-0.3-0.00.5-0.8-0.61.00.60.7
Pavlov. Cond. change in total contacts0.30.51.10.80.50.50.50.1-0.7-0.80.6-0.6-1.0-1.0
Pavlov. Cond. index score0.10.20.9-0.2-0.3-0.3-0.2-0.4-0.4-0.9-0.1-0.1-0.4-0.4
Pavlov. Cond. latency score0.10.10.5-0.1-0.1-0.1-0.1-0.2-0.2-0.7-0.10.0-0.3-0.2
Pavlov. Cond. lever contacts0.50.71.8-0.1-0.3-0.4-0.4-0.9-1.2-0.9-0.2-1.1-1.3-1.3
Pavlov. Cond. magazine entry number0.20.30.9-0.1-0.1-0.3-0.4-0.5-0.70.5-0.3-0.9-0.5-0.6
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.8-0.4-0.6-0.6-0.7-0.10.7-0.5-0.40.10.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.8-0.3-0.3-0.3-0.3-0.4-0.3-0.9-0.1-0.0-0.3-0.2
Pavlov. Cond. response bias0.10.10.50.10.00.00.1-0.2-0.2-0.70.2-0.0-0.4-0.4
Time in closed arm before self-admin0.70.92.31.51.51.31.30.80.10.20.9-0.2-0.7-0.7
Time in closed arm after self-admin1.01.12.71.00.50.50.6-0.3-1.1-1.61.0-0.8-1.5-1.4
Time in open arm before self-admin2.12.35.7-2.4-1.8-1.7-1.6-0.80.9-0.3-1.51.11.71.8
Time in open arm after self-admin1.71.85.11.51.71.51.51.61.22.30.40.60.60.5
Bone: periosteal estimation1.42.96.62.62.42.42.42.00.90.41.70.6-0.2-0.1
Bone: periosteal perimeter1.22.03.91.82.02.01.91.71.00.71.50.60.30.3
Bone: post-yield work0.50.71.51.21.11.11.11.20.70.50.50.60.10.1
Progressive ratio test 1 active lever presses0.30.31.1-1.0-0.8-0.6-0.7-0.30.1-0.40.50.10.50.4
Progressive ratio test 1 breakpoint0.10.20.5-0.7-0.5-0.4-0.4-0.10.1-0.30.60.00.30.3
Progressive ratio test 1 inactive lever presses2.43.49.0-3.0-2.4-2.1-1.9-0.91.0-1.0-0.91.42.12.2
Progressive ratio test 2 active lever presses0.70.92.1-0.7-0.4-0.00.10.61.3-0.70.81.31.41.5
Progressive ratio test 2 breakpoint0.80.92.2-0.8-0.5-0.1-0.00.61.3-0.80.81.41.41.5
Progressive ratio test 2 inactive lever presses1.21.95.1-1.2-0.6-0.2-0.00.72.0-0.80.32.12.22.3
Incentive Sensitization - Responses0.60.81.80.30.60.80.91.11.40.00.51.21.01.0
Incentive Sensitization - Breakpoint0.70.92.20.20.50.70.81.21.5-0.00.51.41.21.2
Sum of active levers in priming session hrs 5-61.11.02.71.21.71.31.31.00.51.3-0.5-0.1-0.3-0.4
Progressive ratio0.20.41.1-0.1-0.10.10.10.30.80.4-0.11.01.10.9
Food seeking constrained by brief footshock0.81.02.11.41.11.21.11.30.41.21.20.30.40.1
Seeking ratio, punishment vs. effort0.20.40.80.50.60.40.30.1-0.60.30.6-0.9-0.8-0.8
Retroperitoneal fat weight0.10.61.5-0.3-0.7-0.6-0.50.40.80.6-1.10.91.21.1
Reaction time number correct0.91.75.2-1.0-0.7-0.5-0.50.51.80.80.21.52.12.3
Reaction time mean minus median0.92.25.92.42.22.02.01.40.41.10.9-0.1-0.9-0.7
Reaction time mean minus median AUC0.81.95.12.32.11.91.91.30.41.00.8-0.0-0.8-0.5
Reaction time num false alarms2.43.47.4-2.7-2.7-2.6-2.5-1.7-0.8-1.7-2.0-0.10.50.4
Reaction time num false alarms AUC2.13.37.4-2.7-2.7-2.5-2.3-1.5-0.4-1.8-1.70.30.90.8
Reaction time trials correct on left0.91.75.2-1.0-0.7-0.5-0.50.51.80.80.21.52.12.3
Reaction time trials on left1.01.85.6-0.9-0.6-0.4-0.40.71.91.00.21.62.22.4
Reaction time mean3.75.913.83.73.43.13.22.91.62.70.51.0-0.10.0
Reaction time mean AUC3.35.312.73.63.22.93.02.71.62.60.11.0-0.10.1
Median of all reaction times4.05.713.13.63.43.03.12.91.72.70.21.10.00.2
Reaction time omissions1.01.52.81.41.51.41.51.71.41.10.11.10.50.7
Reaction time false alarm rate1.82.54.5-1.9-2.1-2.0-1.9-1.6-1.4-2.1-1.5-0.6-0.4-0.5
Reaction time premature initiation rate1.72.35.1-0.4-0.5-0.8-0.7-1.7-2.0-2.0-1.0-1.7-2.3-2.0
Reaction time premature initiations0.50.81.6-0.9-0.9-1.0-0.9-1.2-0.7-1.2-0.7-0.7-0.8-0.5
Std. dev. reaction times2.44.511.43.43.22.92.92.20.92.00.80.3-0.7-0.6
Reaction time trials completed1.01.85.6-0.9-0.6-0.4-0.40.71.91.00.21.62.22.4
Reaction time trials AUC0.91.75.3-1.0-0.7-0.5-0.50.61.80.90.21.62.12.3
Run reversals in cocaine runway, females0.90.91.90.50.70.80.81.01.40.90.31.11.21.1
Run reversals in cocaine runway, males0.50.51.7-0.5-0.5-0.6-0.5-0.9-0.6-1.3-0.7-0.5-0.4-0.6
Latency to leave start box in cocaine runway3.33.88.0-2.8-2.7-2.7-2.7-2.4-1.3-1.1-1.5-0.90.2-0.1
Latency to leave start box in cocaine runway, F2.42.76.1-2.5-2.3-2.2-2.0-1.9-0.7-1.8-1.3-0.30.50.1
Latency to leave start box in cocaine runway, M2.82.65.1-1.8-1.9-2.0-2.2-2.0-1.70.6-1.1-1.8-0.7-0.8
Std. dev. time between licks in bursts1.11.55.0-2.2-1.6-1.3-1.4-1.2-0.5-1.80.7-0.10.30.3
Total sessions with >9 infusions0.60.72.1-1.4-1.2-1.2-1.2-0.8-0.10.0-0.5-0.10.20.5
Short access day 1 total inactive lever presses0.60.71.9-1.0-0.5-0.4-0.30.11.00.1-1.01.11.41.2
Short access day 10 total inactive lever presses0.61.52.8-1.7-1.1-0.9-0.6-0.21.1-1.4-0.71.51.61.5
Short access day 1 total infusions0.20.30.6-0.8-0.5-0.6-0.7-0.40.10.7-0.7-0.10.10.4
Short access day 10 total infusions0.20.21.1-0.5-0.2-0.0-0.10.20.4-0.21.00.40.50.7
Short access total infusions0.10.10.3-0.5-0.4-0.4-0.5-0.3-0.10.20.2-0.20.00.2
Short access day 1 locomotion0.40.41.2-0.9-0.5-0.4-0.50.10.70.60.10.61.01.1
Short access day 10 total locomotion1.32.54.0-2.0-1.8-1.8-1.7-2.0-1.4-2.0-1.4-1.0-1.0-0.8
Short access total locomotion1.41.75.1-2.2-1.7-1.6-1.5-1.10.4-0.2-1.40.40.91.1
One hour access (0.3 mA shock)0.30.31.90.10.10.40.40.40.3-0.91.40.40.10.3
Compulsive drug intake0.50.62.0-0.6-0.7-0.8-0.8-0.9-0.8-0.1-1.4-0.7-0.5-0.6
One hour access (shock baseline)0.71.03.50.60.71.01.01.21.1-0.11.91.10.70.9
Social response proportion1.72.04.32.12.01.71.61.1-0.31.40.9-1.0-1.2-1.4
Social responses0.91.13.50.81.00.70.60.1-1.20.30.3-1.6-1.5-1.9
Social time1.21.74.41.71.81.51.31.3-0.02.10.3-0.7-0.8-0.9
Soleus weight0.41.14.7-0.3-0.1-0.5-0.8-0.9-1.12.2-0.2-1.7-0.7-0.8
Bone: stiffness1.32.14.42.11.81.91.81.70.81.11.90.30.20.1
Tibialis anterior weight0.72.46.9-2.6-2.1-2.0-2.0-2.0-0.8-1.4-0.9-0.30.50.2
Time to tail flick, vehicle, before self-admin0.40.43.1-0.2-0.3-0.1-0.1-0.2-0.4-1.80.7-0.1-0.1-0.2
Time to tail flick, vehicle, after self-admin0.40.53.1-0.4-0.10.20.30.10.5-1.80.80.90.40.6
Time to tail flick, test, before self-admin1.01.11.7-1.2-1.2-1.0-0.8-0.50.8-1.0-0.91.21.21.3
Time to tail flick, test, after self-admin0.40.40.9-0.9-1.0-1.0-0.9-0.6-0.10.0-0.70.10.40.4
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.2-0.2-0.1-0.10.00.40.2-0.00.50.30.5
Delta time to tail flick, test, before/after SA0.80.82.40.70.40.1-0.1-0.2-1.20.90.3-1.6-1.3-1.4
Tibia length2.57.014.13.43.83.63.53.31.92.81.41.00.10.2
Ambulatory time before self-admin1.42.14.21.91.91.82.11.61.60.4-0.21.40.50.6
Ambulatory time after self-admin1.01.22.70.0-0.3-0.6-0.5-1.3-1.2-1.2-1.6-1.2-1.4-1.4
Bone: tissue strength0.70.71.61.00.91.00.91.30.70.80.80.60.40.5
Total heroin consumption0.20.30.60.50.80.70.70.3-0.0-0.50.6-0.2-0.5-0.4
Bone: trabecular number0.40.71.81.31.01.00.90.7-0.30.00.9-0.4-0.8-0.7
Bone: trabecular spacing0.40.51.0-0.6-0.5-0.6-0.6-0.9-0.9-0.2-0.8-1.0-0.6-0.8
Bone: trabecular thickness0.30.41.21.10.80.80.70.5-0.10.20.6-0.1-0.6-0.4
Bone: trabecular tissue density0.20.31.5-0.0-0.3-0.4-0.4-0.00.31.2-1.10.10.30.4
Water consumed over 24 hours0.60.82.4-1.2-1.0-0.8-0.6-0.10.5-1.6-0.41.00.80.8
Number of responses in last shaping day1.01.11.8-1.3-1.2-1.0-0.8-0.40.7-1.1-1.31.01.01.2