Hub : Genes

Tmed4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio NM_001399064.1 0.05 0.03 2.1e-06 0.08 0.06 0.06 0.07 1.3e-07 1.5e-06 2.3e-06 2.4e-07
2 Brain isoform ratio NM_001399065.1 0.05 0.03 1.6e-06 0.08 0.07 0.06 0.08 8.4e-08 1.0e-06 1.5e-06 1.6e-07
3 NAcc mRNA stability Tmed4 0.07 0.04 5.9e-09 0.07 0.06 0.06 0.07 3.4e-08 1.1e-07 7.0e-08 2.5e-08
4 RMTg mRNA stability Tmed4 0.1 0.08 7.8e-03 0.03 0.04 0.01 0.02 5.1e-02 2.9e-02 1.3e-01 9.3e-02
5 IL gene expression Tmed4 0.28 0.15 3.1e-03 0.09 0.07 0.09 0.09 3.5e-03 1.1e-02 4.1e-03 4.6e-03
6 Adipose gene expression Tmed4 0.09 0.06 2.5e-06 0.01 0.03 0.03 0.03 1.8e-02 2.6e-04 2.6e-04 6.5e-04
7 Liver mRNA stability Tmed4 0.52 0.12 0.0e+00 0.34 0.34 0.34 0.34 6.7e-39 2.2e-38 2.9e-38 1.2e-38
8 LHb mRNA stability Tmed4 0.28 0.16 8.1e-04 0.14 0.06 0.1 0.01 3.8e-04 1.9e-02 2.7e-03 1.4e-01
9 Eye mRNA stability Tmed4 0.85 0.08 4.4e-05 0.17 0.16 0.22 0.17 1.5e-03 2.1e-03 2.8e-04 1.3e-03
10 Brain mRNA stability Tmed4 0.52 0.15 0.0e+00 0.39 0.36 0.38 0.38 4.1e-38 2.3e-35 1.4e-36 1.8e-37
11 Liver gene expression Tmed4 0.34 0.13 0.0e+00 0.31 0.32 0.32 0.32 2.8e-35 3.1e-36 7.7e-36 4.0e-36
12 BLA mRNA stability Tmed4 0.15 0.08 1.0e-05 0.07 0.1 0.05 0.07 1.7e-04 5.6e-06 1.2e-03 8.0e-05
13 Adipose mRNA stability Tmed4 0.38 0.12 0.0e+00 0.23 0.29 0.29 0.29 7.5e-25 1.6e-32 2.5e-32 2.0e-32
14 PL mRNA stability Tmed4 0.27 0.13 3.3e-16 0.13 0.14 0.13 0.13 2.3e-14 1.0e-14 9.8e-14 3.5e-14
15 pVTA mRNA stability Tmed4 0.3 0.14 1.1e-10 0.13 0.23 0.22 0.22 3.0e-06 3.0e-10 6.4e-10 1.0e-09
16 Brain gene expression Tmed4 0.29 0.11 0.0e+00 0.15 0.21 0.2 0.2 4.2e-14 3.8e-19 1.7e-18 9.0e-19
17 PL gene expression Tmed4 0.08 0.05 6.3e-06 0.03 0.05 0.05 0.05 2.9e-04 4.4e-06 5.4e-06 5.3e-06
18 BLA gene expression Tmed4 0.11 0.07 2.8e-03 0.05 0.06 0.05 0.05 1.3e-03 6.6e-04 8.2e-04 8.6e-04
19 NAcc gene expression Tmed4 0.22 0.1 4.4e-15 0.1 0.11 0.1 0.1 7.7e-12 1.6e-12 4.6e-11 1.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density0.00.10.1-0.30.30.0-0.0-0.30.30.20.3-0.2-0.0-0.1-0.1-0.2-0.0-0.20.20.20.30.3
Area under the delay curve3.73.96.51.8-1.8-2.3-2.6-1.3-0.11.42.11.72.2-2.5-2.4-2.4-2.1-2.31.92.01.51.7
BMI with tail0.00.10.4-0.10.1-0.3-0.6-0.2-0.20.00.3-0.50.4-0.3-0.2-0.1-0.4-0.30.10.1-0.10.0
BMI without tail0.00.00.1-0.10.10.10.1-0.1-0.3-0.00.3-0.10.20.10.00.1-0.10.1-0.0-0.1-0.1-0.1
Body weight1.04.38.82.7-2.7-2.8-3.0-0.8-1.20.72.61.12.7-2.6-2.3-2.1-2.3-2.21.51.50.81.2
Weight adjusted by age0.30.30.60.8-0.8-0.6-0.7-0.2-0.00.30.70.30.5-0.7-0.6-0.6-0.5-0.60.50.50.40.4
Bone surface0.10.10.30.4-0.4-0.4-0.40.4-0.5-0.40.4-0.30.2-0.1-0.1-0.00.10.1-0.2-0.2-0.3-0.2
Bone volume0.10.10.50.4-0.4-0.5-0.60.2-0.5-0.30.7-0.30.3-0.3-0.2-0.2-0.1-0.1-0.0-0.0-0.2-0.1
Breakpoint value in progressive ratio session0.50.62.50.9-0.9-0.8-0.9-0.2-0.80.21.60.61.0-0.9-0.7-0.6-1.0-0.60.50.40.10.2
Number of licking bursts1.31.55.21.9-1.9-1.9-2.30.3-0.8-0.11.30.11.5-1.6-1.2-1.1-0.9-1.10.50.60.10.3
Context. condit. distance diff. score1.82.24.1-1.61.61.91.70.71.1-0.6-2.0-1.4-2.01.81.71.61.91.4-1.2-1.1-0.6-0.9
Locomotion velocity, session 10.40.50.9-0.80.80.80.90.6-0.3-0.6-0.50.0-0.70.80.70.70.80.9-0.6-0.8-0.6-0.6
Locomotion distance, session 11.41.84.20.2-0.2-0.2-0.0-2.01.81.80.71.20.6-0.9-1.2-1.3-1.0-1.41.71.72.01.9
Locomotion velocity, session 21.72.03.3-1.01.01.11.11.7-1.2-1.7-1.0-0.4-1.21.51.51.51.51.8-1.6-1.8-1.6-1.7
Locomotion distance, session 20.30.41.4-1.01.01.01.2-0.80.90.6-0.30.4-0.50.50.20.10.20.20.30.20.60.5
Locomotion velocity, session 30.40.41.7-0.30.30.91.1-0.31.30.3-0.90.2-1.10.80.60.50.70.4-0.1-0.00.40.1
Locomotion distance, session 30.20.31.21.1-1.1-0.6-0.60.2-0.7-0.30.70.20.5-0.4-0.3-0.2-0.3-0.2-0.0-0.0-0.2-0.2
Stereotopy head waving bouts, day 30.20.21.1-0.70.70.61.1-0.30.50.4-0.30.8-0.40.50.20.10.10.30.20.10.40.2
Stereotopy head waving duration, day 30.81.03.1-1.61.61.51.8-0.21.00.3-1.20.3-1.21.20.80.70.80.8-0.2-0.30.2-0.1
Locomotion velocity, session 70.10.10.40.4-0.4-0.3-0.30.5-0.6-0.40.10.20.2-0.1-0.00.1-0.00.1-0.2-0.2-0.4-0.3
Locomotion distance, session 70.20.31.0-0.60.60.60.20.40.1-0.4-0.5-1.0-0.50.50.50.50.60.4-0.5-0.5-0.4-0.4
Stereotopy head waving bouts, day 70.50.61.8-0.60.60.80.80.50.6-0.4-1.40.4-1.30.90.90.81.00.7-0.7-0.5-0.3-0.5
Stereotopy head waving duration, day 70.20.22.70.5-0.5-0.20.1-0.20.50.3-0.41.7-0.2-0.1-0.2-0.3-0.1-0.30.30.30.40.3
Locomotion velocity, session 81.72.03.8-1.01.01.41.51.30.2-1.3-2.0-0.7-1.71.71.61.52.01.7-1.5-1.4-1.0-1.2
Locomotion distance, session 82.94.29.6-2.72.73.03.10.21.9-0.2-2.7-1.2-2.82.62.21.92.31.9-1.2-1.1-0.2-0.7
Degree of sensitization distance2.22.25.3-2.32.31.91.60.61.0-0.5-2.0-1.5-1.81.71.51.41.71.3-1.1-1.0-0.5-0.7
Degree of sensitization stereotypy0.10.10.80.5-0.5-0.2-0.20.20.1-0.1-0.40.9-0.3-0.10.0-0.00.1-0.1-0.10.0-0.0-0.1
Conditioned locomotion1.31.53.50.3-0.3-0.3-0.0-1.91.71.80.40.90.5-0.8-1.1-1.2-0.9-1.31.61.61.91.8
Cocaine response after cond. corrected0.60.72.11.4-1.4-1.2-1.40.2-0.5-0.21.10.50.9-1.0-0.8-0.8-0.6-0.70.40.40.10.3
Cocaine response after cond. not corrected0.91.02.91.4-1.4-1.3-1.7-0.2-0.40.11.40.51.2-1.3-1.1-1.0-0.9-1.10.60.70.30.5
Cocaine response before conditioning0.10.20.7-0.40.40.20.1-0.70.80.60.0-0.1-0.2-0.0-0.1-0.1-0.1-0.30.30.40.50.4
Saline control response0.50.71.0-0.70.70.90.80.7-0.1-0.8-0.9-0.6-1.01.01.00.91.01.0-0.9-0.9-0.7-0.8
Bone: connectivity density0.10.10.5-0.70.70.50.3-0.00.40.0-0.1-0.5-0.40.30.30.30.30.2-0.1-0.10.0-0.1
Bone: cortical apparent density0.20.31.01.0-1.0-0.8-0.70.3-0.8-0.20.60.60.7-0.5-0.4-0.3-0.5-0.20.10.0-0.2-0.1
Bone: cortical area1.62.45.12.3-2.3-2.1-2.0-0.5-1.10.41.91.02.0-1.8-1.7-1.5-1.7-1.41.11.00.50.8
Bone: cortical porosity0.10.10.1-0.20.2-0.2-0.2-0.40.10.30.30.00.4-0.3-0.4-0.4-0.3-0.30.40.30.30.4
Bone: cortical porosity0.10.10.4-0.60.60.20.2-0.30.50.3-0.2-0.3-0.10.0-0.0-0.10.0-0.10.20.20.30.3
Bone: cortical thickness1.42.33.92.0-2.0-1.9-1.9-0.7-0.70.71.90.81.9-1.8-1.7-1.5-1.8-1.51.21.20.71.0
Bone: cortical thickness0.60.72.40.1-0.1-0.4-0.4-1.11.61.00.20.10.2-0.6-0.7-0.8-0.4-1.01.01.11.31.2
Bone: cortical tissue density0.20.30.91.0-1.0-0.7-0.70.4-0.9-0.30.50.60.7-0.5-0.4-0.3-0.4-0.2-0.0-0.0-0.3-0.2
Condit. Reinf. active minus inactive responses0.50.52.70.7-0.7-0.7-0.71.0-1.6-1.00.40.30.5-0.2-0.00.1-0.00.3-0.6-0.6-1.0-0.8
Condit. Reinf. active-inactive response ratio2.52.74.8-1.01.01.00.61.9-1.5-2.1-1.0-1.4-1.21.41.71.81.61.9-2.1-2.1-2.2-2.2
Condit. Reinf. active responses0.20.31.00.9-0.9-0.8-0.70.4-1.0-0.50.50.80.6-0.4-0.4-0.3-0.2-0.1-0.0-0.1-0.3-0.1
Condit. Reinf. inactive responses1.21.42.11.5-1.5-1.3-1.1-0.80.30.91.11.21.2-1.3-1.4-1.4-1.1-1.31.21.21.11.2
Incentive salience index mean0.81.02.41.5-1.5-1.5-1.40.2-1.3-0.31.21.01.2-1.1-0.9-0.8-0.8-0.60.30.2-0.20.1
Condit. Reinf. lever presses2.02.73.82.0-2.0-1.8-1.3-1.40.21.31.61.91.6-1.8-1.9-1.9-1.7-1.71.71.71.51.7
Condit. Reinf. active minus inactive responses0.10.10.4-0.40.40.50.6-0.10.50.1-0.6-0.3-0.40.40.30.20.40.2-0.1-0.10.10.0
Condit. Reinf. active-inactive response ratio0.20.20.30.5-0.5-0.4-0.4-0.40.20.40.20.40.5-0.5-0.5-0.6-0.5-0.50.50.50.50.5
Condit. Reinf. active responses0.20.30.9-0.70.70.81.0-0.20.50.2-0.7-0.4-0.60.60.40.40.40.4-0.1-0.20.10.0
Condit. Reinf. inactive responses1.01.22.1-1.41.41.41.50.40.4-0.4-1.2-1.2-1.31.31.21.11.11.2-0.9-0.9-0.5-0.7
Condit. Reinf. lever presses0.10.10.5-0.30.30.40.4-0.00.60.1-0.7-0.5-0.50.40.30.20.50.2-0.1-0.10.20.1
Condit. Reinf. lever reinforcers received0.10.20.6-0.60.60.60.8-0.20.50.2-0.5-0.4-0.40.50.30.20.30.3-0.0-0.10.20.1
Conditioned reinforcement - actives0.10.10.70.3-0.3-0.20.4-0.2-0.20.20.00.80.10.0-0.2-0.2-0.20.10.20.10.20.2
Conditioned reinforcement - inactives0.00.00.10.3-0.3-0.3-0.2-0.10.10.10.2-0.00.0-0.2-0.1-0.1-0.1-0.20.10.10.10.1
Conditioned locomotion0.30.42.60.6-0.6-0.70.3-0.5-0.40.50.31.60.6-0.3-0.6-0.6-0.7-0.30.60.40.40.5
Patch foraging indifference point 0 sec1.21.95.10.8-0.8-0.9-1.92.1-2.1-2.30.6-1.90.4-0.20.50.80.50.5-1.5-1.3-2.0-1.7
Patch foraging indifference point AUC0.30.30.9-0.00.00.00.21.0-0.8-0.8-0.4-0.5-0.10.40.40.40.60.7-0.6-0.8-0.7-0.6
Delay disc. indifference point, 0s delay0.80.94.51.0-1.0-1.4-2.1-0.40.40.31.0-0.70.8-1.3-0.9-0.8-0.7-1.30.50.90.40.5
Delay disc. indifference point, 16s delay1.21.22.41.1-1.1-1.4-1.5-0.2-0.90.31.51.31.5-1.4-1.3-1.2-1.3-1.10.80.80.40.6
Delay disc. indifference point, 2s delay3.33.76.51.7-1.7-2.0-2.5-1.70.81.71.90.91.7-2.4-2.2-2.2-1.9-2.51.92.21.71.9
Delay disc. indifference point, 24s delay0.90.82.20.6-0.6-0.9-1.5-0.4-0.50.51.20.41.4-1.3-1.1-1.1-1.1-1.10.70.80.40.5
Delay disc. indifference point, 4s delay4.64.97.72.4-2.4-2.6-2.8-1.60.11.52.11.82.3-2.8-2.6-2.6-2.2-2.62.12.21.72.0
Delay disc. indifference point, 8s delay2.22.23.51.3-1.3-1.4-1.4-1.30.31.41.21.61.5-1.7-1.8-1.9-1.5-1.71.71.61.51.6
Indifference point function ln k0.50.71.30.4-0.4-0.5-0.5-1.10.61.10.80.90.6-0.8-0.9-0.9-0.9-1.01.01.01.01.0
Indifference point function log k0.50.71.30.4-0.4-0.5-0.5-1.10.61.10.80.90.6-0.8-0.9-0.9-0.9-1.01.01.01.01.0
Patch foraging total patch changes 0 sec1.42.36.10.8-0.8-0.9-1.92.3-2.3-2.50.5-2.10.3-0.10.60.90.60.7-1.7-1.5-2.2-1.9
Patch foraging total patch changes 12 sec1.21.64.20.1-0.1-0.5-1.02.0-2.0-2.00.1-2.10.20.20.70.90.60.9-1.5-1.4-1.9-1.6
Patch foraging total patch changes 18 sec1.82.46.40.8-0.8-0.8-1.42.5-2.3-2.5-0.2-2.10.10.20.81.00.91.0-1.8-1.7-2.2-1.9
Patch foraging total patch changes 24 sec3.54.28.0-1.31.31.30.92.4-0.7-2.4-2.0-2.8-1.82.02.32.32.52.2-2.5-2.4-2.2-2.3
Patch foraging total patch changes 6 sec1.21.85.80.7-0.7-0.9-1.52.1-2.4-2.10.7-1.40.6-0.10.40.70.40.7-1.4-1.4-2.0-1.7
Patch foraging time to switch 0 sec0.10.21.0-0.50.50.50.5-0.71.00.7-0.50.1-0.40.10.0-0.1-0.1-0.20.40.40.60.5
Patch foraging water rate 0 sec0.71.25.51.2-1.2-1.0-1.11.5-2.3-1.60.8-0.00.9-0.3-0.00.2-0.10.4-0.8-0.9-1.4-1.1
Patch foraging water rate 12 sec0.10.10.40.6-0.6-0.5-0.30.2-0.5-0.30.20.30.2-0.2-0.1-0.1-0.00.0-0.1-0.1-0.2-0.1
Patch foraging water rate 18 sec2.02.75.20.9-0.9-0.9-0.7-2.31.32.21.41.61.2-1.5-1.7-1.7-1.8-1.92.02.12.02.0
Patch foraging water rate 24 sec0.10.11.00.4-0.4-0.20.4-0.2-0.60.10.31.00.30.0-0.1-0.1-0.30.10.1-0.1-0.1-0.0
Patch foraging water rate 6 sec0.91.43.81.4-1.4-1.2-0.4-0.9-0.10.91.22.01.3-1.0-1.3-1.4-1.2-0.91.31.01.01.2
Seeking ratio, delayed vs. immediate footshock1.51.76.00.3-0.3-0.20.7-2.20.91.90.72.40.5-0.6-1.1-1.2-1.2-1.01.61.41.71.6
Distance traveled before self-admin0.30.30.90.5-0.5-0.10.11.0-0.7-0.9-0.4-0.3-0.00.40.40.50.40.6-0.6-0.7-0.7-0.7
Distance traveled after self-admin0.50.51.31.1-1.1-0.8-0.4-0.4-0.20.50.81.10.8-0.7-0.8-0.8-0.7-0.60.70.60.50.7
Extensor digitorum longus weight1.04.09.12.8-2.8-2.7-2.90.4-3.0-0.43.01.22.8-2.3-1.8-1.5-2.1-1.30.60.5-0.5-0.0
Bone: elastic displacement0.30.41.2-1.11.11.10.9-0.10.60.1-0.4-0.5-0.70.70.60.60.40.4-0.3-0.2-0.1-0.2
Bone: elastic work0.30.40.90.2-0.2-0.3-0.5-0.70.30.70.90.00.7-0.7-0.7-0.6-0.8-0.80.70.80.60.7
Bone: endosteal estimation0.00.10.30.5-0.5-0.4-0.40.1-0.1-0.10.0-0.00.1-0.2-0.2-0.20.0-0.10.10.10.00.1
Bone: endosteal perimeter0.91.83.41.8-1.8-1.7-1.3-0.8-0.00.91.31.41.4-1.5-1.5-1.5-1.3-1.41.31.31.01.2
Epididymis fat weight0.10.31.1-1.11.10.60.2-0.31.00.3-0.7-0.8-0.60.40.50.50.3-0.0-0.20.00.1-0.1
Delta time in closed arm before/after self-admin2.32.26.4-1.91.92.22.5-1.72.51.9-1.80.8-1.81.20.70.40.50.30.50.51.30.8
Delta time in open arm before/after self-admin2.52.47.52.3-2.3-2.2-2.31.6-2.7-1.61.8-0.32.0-1.2-0.7-0.4-0.9-0.3-0.3-0.4-1.2-0.8
Diff in mean of infusions in LGA sessions0.30.31.0-0.10.10.2-0.1-1.00.91.00.10.3-0.0-0.3-0.3-0.4-0.5-0.70.60.70.70.6
Delay discount exponential model param3.63.86.3-1.81.82.22.51.40.0-1.4-2.0-1.6-2.22.52.42.32.02.3-1.9-2.0-1.5-1.7
Extinction: sum of active levers before priming0.30.31.20.8-0.8-0.5-0.1-0.0-0.80.20.81.10.6-0.4-0.4-0.3-0.7-0.20.30.1-0.10.0
Active lever presses in extinction session 60.50.41.10.1-0.1-0.1-0.5-1.00.41.00.80.50.4-0.7-0.6-0.6-1.0-0.90.70.80.60.5
Bone: final force0.10.21.30.5-0.5-0.4-0.30.4-1.1-0.60.4-0.30.5-0.1-0.1-0.0-0.00.3-0.2-0.4-0.5-0.4
Bone: final moment0.20.31.40.7-0.7-0.6-0.50.4-1.2-0.50.6-0.20.7-0.3-0.3-0.2-0.20.1-0.1-0.3-0.5-0.3
Food consumed during 24 hour testing period0.60.74.20.3-0.3-0.4-0.61.2-2.1-1.40.5-0.40.6-0.00.10.30.10.6-0.8-0.9-1.3-1.1
Glucose5.58.341.51.3-1.3-1.3-1.64.5-6.4-4.50.9-0.81.10.31.01.50.72.4-3.0-3.4-4.5-3.8
Heart weight1.21.72.4-1.11.11.00.61.4-0.3-1.4-1.4-1.4-1.31.31.51.51.51.3-1.5-1.4-1.4-1.4
Delay discount hyperbolic model param4.04.27.3-1.91.92.42.71.4-0.0-1.5-2.1-1.6-2.22.62.52.42.12.5-2.0-2.1-1.6-1.8
Intermittent access intake day 1-15 change1.21.24.00.2-0.2-0.2-0.22.0-1.4-2.0-0.1-1.40.00.60.80.90.91.0-1.3-1.3-1.4-1.3
Intermittent access intake escalation1.21.23.5-0.00.00.0-0.11.9-1.2-1.9-0.2-1.5-0.20.70.91.00.91.0-1.3-1.3-1.4-1.3
Intermittent access intake escalation 21.81.85.0-0.00.00.20.22.2-1.2-2.2-0.2-1.9-0.51.01.21.31.41.4-1.6-1.6-1.7-1.6
Intermitt. access day 1 inactive lever presses1.01.13.30.0-0.0-0.00.5-1.81.31.80.11.7-0.1-0.4-0.8-0.9-0.6-0.81.21.21.51.3
Intermitt. access day 15 inactive lever presses0.50.52.10.9-0.9-1.1-0.70.8-1.4-0.81.00.30.9-0.4-0.4-0.2-0.40.0-0.1-0.3-0.6-0.4
Intermitt. access escalation Index1.11.03.1-0.20.20.10.01.7-1.2-1.70.0-1.2-0.20.70.80.90.91.0-1.2-1.2-1.3-1.2
Intermittent access day 1 total infusions0.30.41.2-0.30.30.00.2-1.11.11.1-0.10.5-0.2-0.2-0.4-0.5-0.2-0.50.70.70.90.8
Intermittent access day 15 total infusions0.10.10.4-0.00.0-0.3-0.30.6-0.4-0.60.2-0.60.10.10.20.30.20.2-0.4-0.3-0.5-0.4
Intermittent access terminal intake (last 3 days)0.60.71.9-0.20.2-0.0-0.01.4-0.7-1.4-0.2-1.3-0.30.60.80.80.80.8-1.0-1.0-1.0-1.0
Intermittent access total infusions0.00.00.1-0.20.2-0.2-0.20.2-0.0-0.20.1-0.4-0.10.00.10.10.10.0-0.2-0.1-0.1-0.1
Intermittent access day 1 locomotion1.21.24.1-0.60.60.71.3-2.01.22.0-0.41.9-0.3-0.0-0.5-0.6-0.7-0.51.11.01.41.2
Intermittent access day 15 total locomotion0.50.61.80.5-0.5-0.5-0.3-1.0-0.11.00.61.30.7-0.7-0.8-0.7-1.2-0.80.80.70.60.6
Intermittent access total locomotion0.80.92.70.5-0.5-0.7-0.3-1.20.11.30.71.60.8-0.9-1.0-1.0-1.2-1.01.11.00.91.0
Intermittent access standard deviation2.82.94.6-1.61.61.72.11.6-0.2-1.6-1.7-1.2-1.72.12.01.92.02.1-1.7-1.8-1.4-1.6
Left kidney weight0.61.72.81.0-1.0-0.9-0.9-1.71.51.60.61.10.7-1.2-1.2-1.3-1.1-1.61.51.71.71.7
Right kidney weight0.51.56.9-0.10.10.2-0.1-1.92.61.9-0.20.3-0.3-0.5-0.6-0.7-0.5-1.41.31.61.81.6
Cocaine induced anxiety0.91.13.61.5-1.5-1.2-1.10.4-1.9-0.41.60.81.5-1.0-0.9-0.7-1.1-0.40.30.1-0.4-0.1
Post-drug Anxiety0.20.20.80.8-0.8-0.5-0.50.5-0.9-0.50.60.20.6-0.4-0.3-0.3-0.20.00.0-0.1-0.2-0.1
Baseline Anxiety0.20.21.2-0.60.60.3-0.2-0.41.10.4-0.5-0.3-0.5-0.00.0-0.00.3-0.30.10.30.40.3
Tail length0.92.86.02.5-2.5-2.1-1.6-0.5-1.30.52.41.92.0-1.8-1.8-1.7-1.7-1.31.31.10.60.9
Length with tail1.66.011.53.4-3.4-3.2-2.8-1.0-1.11.02.92.32.9-2.9-2.7-2.6-2.5-2.42.01.91.31.7
Length without tail0.91.93.51.9-1.9-1.9-1.8-0.5-0.50.61.41.11.6-1.7-1.5-1.4-1.5-1.41.11.10.70.9
Times rat made contact with spout5.96.810.0-2.32.32.11.42.9-1.8-3.0-2.1-2.6-2.02.52.72.92.63.0-3.1-3.1-3.1-3.2
Lifetime Intake0.00.00.1-0.10.1-0.3-0.1-0.0-0.00.00.1-0.00.1-0.1-0.0-0.0-0.1-0.10.00.0-0.00.0
Liver weight, left0.81.24.4-1.41.41.21.5-1.72.11.6-0.50.1-0.70.40.0-0.2-0.1-0.30.90.91.41.1
Liver weight, right2.54.213.3-0.90.90.81.5-3.43.73.4-0.41.7-0.3-0.3-1.0-1.3-1.0-1.52.42.43.12.8
Locomotor activity0.71.23.10.0-0.0-0.1-0.21.7-1.5-1.8-0.2-1.0-0.30.60.80.91.01.1-1.4-1.4-1.6-1.5
Locomotor testing distance0.20.30.80.7-0.7-0.9-0.8-0.0-0.1-0.10.60.20.5-0.6-0.5-0.6-0.2-0.50.30.30.20.3
Locomotor testing rearing0.60.93.71.2-1.2-1.3-1.31.3-1.9-1.30.8-0.10.8-0.5-0.20.0-0.10.2-0.6-0.7-1.1-0.8
Locomotion in novel chamber2.02.58.2-2.12.12.21.0-0.72.90.7-2.4-2.3-2.21.21.41.21.40.3-0.6-0.10.4-0.1
Locomotion in novel chamber post-restriction0.91.14.0-1.31.31.41.5-0.72.00.9-1.7-0.2-1.41.00.70.40.80.30.10.20.80.5
Fecal boli incidents, locomotor time 10.10.10.3-0.40.40.60.5-0.40.40.40.10.2-0.20.10.00.0-0.1-0.00.20.20.30.2
Change in fecal boli incidents, locomotor task1.11.12.2-0.30.30.30.31.4-1.2-1.5-1.1-0.9-0.30.90.91.10.91.2-1.3-1.3-1.4-1.3
Time >=10cm from walls, locomotor time 10.30.30.8-0.90.90.70.3-0.10.6-0.1-0.4-0.7-0.70.50.60.60.40.2-0.3-0.2-0.1-0.2
Bouts of movement, locomotor time 11.01.13.50.1-0.1-0.6-0.71.7-0.9-1.9-0.5-1.7-0.30.40.80.91.10.8-1.3-1.2-1.4-1.3
Total resting periods, locomotor time 10.80.82.5-0.20.2-0.4-0.21.4-0.8-1.6-0.7-1.1-0.40.60.80.91.00.8-1.2-1.1-1.2-1.1
Rest time, locomotor task time 10.20.20.4-0.60.60.00.40.6-0.2-0.5-0.5-0.2-0.40.50.40.40.50.5-0.5-0.5-0.4-0.4
Distance moved, locomotor task time 10.70.71.70.9-0.9-0.5-0.5-0.8-0.21.00.91.30.9-0.9-1.0-0.9-1.1-0.80.90.80.70.7
Vertical activity count, locomotor time 10.10.10.30.3-0.3-0.2-0.3-0.4-0.10.30.50.20.4-0.4-0.3-0.3-0.4-0.30.30.20.20.2
Time >=10cm from walls, locomotor time 20.70.82.0-0.50.50.30.8-1.31.41.3-0.21.3-0.3-0.1-0.5-0.7-0.3-0.51.00.91.31.2
Bouts of movement, locomotor time 23.84.16.22.1-2.1-2.0-1.4-2.00.91.91.22.21.8-2.1-2.4-2.5-1.8-2.22.32.32.32.5
Total resting periods, locomotor time 23.03.24.92.0-2.0-1.9-1.4-1.60.61.41.11.81.6-1.9-2.1-2.2-1.6-1.92.01.91.92.1
Rest time, locomotor task time 20.70.81.4-0.80.80.60.61.2-0.7-1.0-0.8-0.6-0.60.90.91.00.71.0-1.0-1.0-1.0-1.0
Distance moved, locomotor task time 20.10.10.5-0.10.10.20.3-0.50.70.6-0.00.1-0.20.0-0.1-0.20.0-0.20.30.30.50.4
Vertical activity count, locomotor time 20.30.31.4-0.80.80.60.3-0.91.20.70.0-0.5-0.50.10.10.00.2-0.20.30.40.60.4
Light reinforcement 10.20.40.70.8-0.8-0.8-0.6-0.4-0.00.40.50.70.7-0.8-0.8-0.8-0.6-0.70.70.60.50.6
Light reinforcement 22.63.55.41.3-1.3-1.2-1.0-2.21.52.21.32.11.3-1.8-2.0-2.1-1.7-2.12.22.32.32.3
Bone: marrow area0.00.00.20.4-0.4-0.3-0.30.10.0-0.1-0.1-0.00.0-0.2-0.2-0.20.1-0.10.10.10.10.1
Bone: maximum diameter1.52.76.92.6-2.6-2.5-2.40.5-2.2-0.51.91.12.1-1.8-1.5-1.2-1.4-1.00.50.3-0.40.0
Bone: maximum force0.10.20.80.9-0.9-0.7-0.60.0-0.6-0.10.60.00.6-0.5-0.5-0.4-0.4-0.30.20.1-0.00.1
Bone: maximum moment0.20.41.11.0-1.0-0.9-0.8-0.1-0.7-0.10.80.10.8-0.7-0.6-0.6-0.6-0.40.30.30.00.2
Mean time between licks in bursts0.40.61.60.4-0.4-0.2-0.11.2-1.1-1.30.1-0.1-0.30.40.50.60.70.8-0.9-1.0-1.1-1.0
Mean num. licks in bursts4.95.89.3-3.03.02.82.81.6-0.4-1.8-2.4-1.6-2.52.82.72.72.42.8-2.3-2.5-2.0-2.2
Cd content in liver0.10.10.7-0.20.20.10.5-0.40.30.4-0.10.8-0.10.1-0.0-0.1-0.1-0.00.20.20.30.3
Co content in liver0.20.20.80.1-0.1-0.2-0.20.7-0.9-0.7-0.20.10.00.10.20.30.20.4-0.5-0.5-0.7-0.6
Cu content in liver0.20.21.60.1-0.1-0.2-0.10.6-1.2-0.60.4-0.10.30.10.20.3-0.10.4-0.4-0.6-0.8-0.6
Fe content in liver0.30.41.1-1.01.00.91.00.2-0.0-0.2-0.7-0.3-0.60.80.60.60.60.7-0.4-0.5-0.3-0.4
K content in liver3.03.03.71.9-1.9-1.6-1.1-1.60.61.61.81.91.7-1.7-1.8-1.8-1.9-1.91.91.91.71.8
Mg content in liver0.30.41.11.1-1.1-0.7-0.6-0.2-0.40.20.80.50.7-0.6-0.5-0.4-0.7-0.50.40.40.10.2
Mn content in liver1.82.14.01.4-1.4-1.2-0.6-1.30.51.31.52.01.3-1.3-1.6-1.6-1.5-1.41.71.61.51.6
Na content in liver1.01.13.71.5-1.5-1.6-1.90.7-1.4-0.71.3-0.01.3-1.2-0.9-0.7-0.7-0.60.10.1-0.4-0.1
Rb content in liver1.11.33.21.6-1.6-1.6-1.10.1-1.8-0.11.71.31.7-1.1-1.0-0.8-1.4-0.60.50.3-0.20.1
Se content in liver1.21.53.51.4-1.4-1.4-1.3-0.4-0.90.41.91.31.7-1.4-1.4-1.2-1.5-1.11.00.90.50.7
Sr content in liver0.70.73.10.9-0.9-1.0-1.80.2-0.8-0.20.9-0.41.1-1.1-0.8-0.6-0.9-0.80.30.4-0.10.0
Zn content in liver1.21.32.01.3-1.3-1.1-0.7-1.0-0.01.01.11.31.2-1.2-1.2-1.2-1.4-1.21.21.11.01.1
Bone: minimum diameter0.10.20.40.5-0.5-0.40.1-0.70.30.60.20.50.4-0.3-0.4-0.4-0.6-0.50.60.50.60.6
Time in familiar zone, hab. session 10.00.00.10.4-0.4-0.1-0.0-0.00.2-0.1-0.30.3-0.10.00.0-0.00.20.0-0.00.00.10.1
Time in novel zone, hab. session 10.20.20.4-0.50.50.30.00.5-0.7-0.40.1-0.50.00.20.30.40.10.4-0.5-0.5-0.6-0.6
Total zone transitions, hab. session 10.00.10.6-0.10.10.10.2-0.20.00.10.20.80.1-0.1-0.2-0.2-0.1-0.10.20.20.20.2
Total locomotion distance, hab. session 11.01.42.21.1-1.1-1.0-0.9-1.10.81.11.01.50.9-1.2-1.3-1.3-1.0-1.31.31.41.31.4
Locomotion velocity, hab. session 10.50.71.20.7-0.7-0.6-0.5-0.80.90.80.60.90.5-0.8-0.8-0.9-0.6-0.91.01.01.11.1
Time in familiar zone, hab. session 20.50.51.4-0.90.91.11.2-0.10.80.2-1.1-0.4-1.00.90.80.70.60.5-0.3-0.30.0-0.2
Time in novel zone, hab. session 20.50.52.70.4-0.4-0.7-0.90.8-1.6-0.90.9-0.20.8-0.4-0.2-0.1-0.20.1-0.4-0.5-0.9-0.6
Total zone transitions, hab. session 21.21.52.31.0-1.0-1.1-0.9-1.1-0.21.01.41.31.5-1.3-1.5-1.5-1.5-1.21.41.21.11.2
Total locomotion distance, hab. session 21.31.82.81.3-1.3-1.4-1.2-0.9-0.30.91.51.51.7-1.5-1.6-1.5-1.6-1.41.41.31.01.2
Locomotion velocity, hab. session 22.23.04.21.8-1.8-1.8-1.5-1.3-0.11.31.91.82.0-1.9-2.0-2.0-2.0-1.81.81.71.41.7
Novel to familiar place preference ratio0.20.20.5-0.10.10.10.10.6-0.7-0.7-0.1-0.3-0.20.30.30.30.40.5-0.5-0.6-0.6-0.6
Novelty place preference0.30.30.6-0.30.30.30.20.7-0.8-0.7-0.1-0.4-0.20.40.40.50.50.7-0.6-0.7-0.8-0.7
Time in novel zone, NPP test0.40.50.9-0.40.40.40.20.9-0.9-0.9-0.1-0.6-0.30.50.60.70.60.8-0.8-0.9-1.0-0.9
Total zone transitions, NPP test0.91.22.60.1-0.1-0.2-0.2-1.61.31.50.70.80.6-0.8-1.0-1.1-1.0-1.21.41.51.61.5
Total locomotion distance, NPP test1.72.33.80.8-0.8-0.8-0.8-1.91.41.81.41.31.1-1.4-1.6-1.6-1.5-1.81.91.91.91.9
Locomotion velocity, NPP test1.92.74.31.1-1.1-1.0-0.9-2.01.21.91.51.51.4-1.6-1.8-1.8-1.7-1.92.02.02.02.1
Intraocular pressure0.20.21.11.1-1.1-0.6-0.60.4-0.7-0.50.40.10.4-0.3-0.2-0.2-0.00.0-0.2-0.2-0.3-0.2
Delta distance traveled before/after self-admin0.90.92.30.2-0.2-0.3-0.1-1.51.11.40.71.10.3-0.7-0.9-1.1-0.7-1.01.21.21.31.3
Delta ambulatory time before/after self-admin0.60.71.9-0.20.20.1-0.0-1.41.21.30.50.70.0-0.5-0.6-0.8-0.5-0.81.01.01.21.1
Parametrial fat weight0.50.92.41.0-1.0-1.3-1.20.1-1.5-0.21.50.81.5-1.1-1.0-0.8-1.0-0.60.40.2-0.20.1
Pavlov. Cond. lever latency0.40.51.40.1-0.10.0-0.21.2-1.1-1.1-0.5-0.5-0.10.40.60.70.50.7-0.9-0.9-1.2-1.1
Pavlov. Cond. magazine entry latency0.30.41.3-0.60.60.91.1-0.41.10.2-0.9-0.0-1.00.80.60.40.80.4-0.1-0.10.30.1
Pavlov. Cond. change in total contacts0.80.82.11.5-1.5-1.3-1.00.1-1.1-0.21.11.21.1-0.9-0.9-0.9-0.8-0.50.40.30.00.2
Pavlov. Cond. index score0.30.41.9-0.30.30.60.9-0.91.40.8-0.40.4-0.70.30.1-0.10.2-0.10.40.50.90.7
Pavlov. Cond. latency score0.30.41.7-0.30.30.50.9-1.01.30.9-0.20.4-0.50.2-0.0-0.20.1-0.20.60.60.90.7
Pavlov. Cond. lever contacts0.30.31.0-0.00.00.10.5-1.00.70.90.20.70.0-0.2-0.4-0.5-0.4-0.40.80.70.90.8
Pavlov. Cond. magazine entry number0.50.61.70.6-0.6-1.0-1.3-0.1-0.80.21.20.11.3-1.1-0.9-0.7-1.1-0.80.50.50.10.3
Pavlov. Cond. intertrial magazine entries3.13.76.01.4-1.4-1.8-1.4-1.91.11.91.61.61.8-2.0-2.2-2.4-1.9-2.22.32.32.32.4
Pavlov. Cond. lever-magazine prob. diff.0.40.41.9-0.40.40.71.1-1.01.40.8-0.60.4-0.70.40.1-0.00.30.00.40.40.90.7
Pavlov. Cond. response bias0.10.10.40.0-0.00.20.6-0.50.50.4-0.10.6-0.30.20.0-0.10.10.00.20.20.40.3
Pavlov. Cond. lever latency3.85.17.62.7-2.7-2.7-2.5-1.3-0.71.32.82.12.7-2.7-2.5-2.4-2.7-2.42.02.01.31.7
Pavlov. Cond. magazine entry latency0.00.00.20.1-0.1-0.00.10.20.2-0.2-0.3-0.2-0.40.20.20.10.50.2-0.2-0.1-0.1-0.1
Pavlov. Cond. change in total contacts0.20.30.7-0.80.80.70.80.30.3-0.2-0.6-0.2-0.70.70.60.50.70.6-0.4-0.4-0.2-0.3
Pavlov. Cond. index score1.01.32.2-1.41.41.31.30.50.7-0.5-1.5-1.1-1.51.41.21.11.51.1-0.9-0.8-0.4-0.6
Pavlov. Cond. latency score0.70.91.8-1.21.21.21.20.30.8-0.3-1.3-0.8-1.31.21.00.91.30.9-0.7-0.6-0.2-0.4
Pavlov. Cond. lever contacts2.94.06.7-2.32.32.42.41.10.8-1.1-2.6-1.7-2.52.42.22.02.52.2-1.7-1.7-1.1-1.4
Pavlov. Cond. magazine entry number1.01.21.80.8-0.8-0.8-0.6-1.30.61.30.91.21.0-1.1-1.2-1.2-1.3-1.31.31.31.31.3
Pavlov. Cond. intertrial magazine entries0.10.10.20.3-0.3-0.2-0.3-0.1-0.10.30.20.00.4-0.3-0.3-0.3-0.4-0.30.30.30.20.2
Pavlov. Cond. lever-magazine prob. diff.0.91.22.1-1.31.31.31.30.50.7-0.5-1.4-1.1-1.51.31.21.11.41.1-0.9-0.8-0.4-0.6
Pavlov. Cond. response bias2.12.94.8-1.81.81.81.81.30.3-1.2-2.0-1.7-2.02.01.91.82.21.9-1.6-1.6-1.2-1.4
Time in closed arm before self-admin0.20.20.8-0.00.0-0.3-0.30.7-0.8-0.80.9-0.40.3-0.00.00.10.20.3-0.3-0.4-0.5-0.4
Time in closed arm after self-admin0.70.72.2-1.51.51.31.5-0.61.20.6-0.70.1-1.10.80.50.30.70.50.00.00.50.3
Time in open arm before self-admin0.80.93.6-1.21.21.21.2-0.91.90.9-1.50.0-1.40.70.50.30.80.20.10.30.80.5
Time in open arm after self-admin0.10.10.50.7-0.7-0.30.10.3-0.6-0.3-0.30.40.20.0-0.00.1-0.10.2-0.1-0.2-0.3-0.2
Bone: periosteal estimation0.51.02.61.6-1.6-1.5-1.3-0.3-0.60.21.10.51.2-1.2-1.1-1.0-1.0-0.90.70.70.30.5
Bone: periosteal perimeter1.83.05.92.4-2.4-2.2-2.0-1.0-0.40.91.81.62.0-2.0-1.9-1.8-1.9-1.81.51.51.11.3
Bone: post-yield work0.10.10.50.7-0.7-0.6-0.60.0-0.10.00.30.30.3-0.4-0.3-0.3-0.2-0.40.20.20.10.2
Progressive ratio test 1 active lever presses0.10.10.3-0.10.1-0.20.2-0.40.20.40.20.60.0-0.1-0.3-0.4-0.0-0.10.40.30.40.4
Progressive ratio test 1 breakpoint0.10.20.3-0.40.40.10.5-0.50.60.5-0.10.6-0.20.1-0.2-0.30.1-0.10.40.30.60.5
Progressive ratio test 1 inactive lever presses3.84.19.51.9-1.9-2.1-1.3-1.9-0.51.92.23.12.1-2.2-2.4-2.3-2.4-1.92.11.91.61.8
Progressive ratio test 2 active lever presses0.00.00.2-0.10.1-0.3-0.20.20.2-0.20.1-0.4-0.20.00.10.10.40.0-0.2-0.1-0.1-0.1
Progressive ratio test 2 breakpoint0.10.10.4-0.00.0-0.3-0.20.50.0-0.50.1-0.6-0.20.10.20.20.50.2-0.4-0.3-0.3-0.3
Progressive ratio test 2 inactive lever presses0.60.71.80.9-0.9-1.1-0.6-0.6-0.40.61.01.41.0-0.9-0.9-0.9-1.0-0.80.70.70.50.6
Incentive Sensitization - Responses0.20.21.1-0.20.2-0.1-0.40.7-0.1-0.7-0.3-1.0-0.30.20.50.60.50.2-0.6-0.5-0.6-0.6
Incentive Sensitization - Breakpoint0.40.41.8-0.30.30.0-0.40.9-0.0-0.9-0.3-1.4-0.40.30.70.70.60.3-0.8-0.6-0.8-0.7
Sum of active levers in priming session hrs 5-60.90.91.71.1-1.1-1.1-1.2-0.5-0.50.51.30.91.2-1.1-1.0-0.9-1.3-1.00.70.70.30.5
Progressive ratio0.30.31.2-0.60.60.60.4-1.10.71.00.10.7-0.1-0.1-0.1-0.1-0.5-0.40.50.50.60.4
Food seeking constrained by brief footshock4.45.48.82.0-2.0-2.3-1.9-2.30.42.32.23.02.2-2.6-2.6-2.6-2.7-2.62.52.52.12.3
Seeking ratio, punishment vs. effort1.51.93.91.9-1.9-2.0-1.5-0.5-0.40.61.31.31.5-1.6-1.6-1.6-1.2-1.31.21.10.91.2
Retroperitoneal fat weight0.20.71.20.3-0.3-0.6-0.8-1.00.51.00.50.20.8-0.9-0.9-0.9-0.9-1.11.01.00.91.0
Reaction time number correct0.30.51.10.2-0.20.30.11.0-0.9-1.0-0.3-0.4-0.30.50.60.70.60.8-0.9-0.9-1.0-1.0
Reaction time mean minus median2.73.55.2-2.12.12.11.61.40.4-1.3-2.3-2.0-2.22.12.22.12.21.9-1.9-1.7-1.4-1.6
Reaction time mean minus median AUC2.12.74.4-1.81.81.81.31.30.5-1.3-1.9-1.9-2.01.81.91.82.11.6-1.7-1.5-1.2-1.4
Reaction time num false alarms0.81.12.31.2-1.2-1.4-1.5-0.6-0.20.41.40.31.3-1.3-1.2-1.1-1.1-1.20.80.90.60.7
Reaction time num false alarms AUC1.31.73.41.3-1.3-1.5-1.9-1.00.20.91.60.31.5-1.7-1.4-1.4-1.4-1.71.21.41.01.1
Reaction time trials correct on left0.30.51.10.2-0.20.30.11.0-0.9-1.0-0.3-0.4-0.30.50.60.70.60.8-0.9-0.9-1.0-1.0
Reaction time trials on left0.30.51.10.2-0.20.30.21.0-0.8-1.0-0.3-0.5-0.30.60.70.80.60.8-0.9-0.9-1.0-1.0
Reaction time mean0.30.51.6-1.21.21.10.80.00.80.2-0.9-0.3-0.80.70.70.70.50.4-0.3-0.2-0.0-0.2
Reaction time mean AUC0.50.61.9-1.41.41.20.9-0.21.20.4-1.0-0.3-1.00.80.70.60.50.3-0.2-0.10.2-0.1
Median of all reaction times0.20.20.6-0.80.80.60.5-0.50.80.7-0.30.4-0.20.20.10.0-0.2-0.20.30.40.50.3
Reaction time omissions0.50.62.0-1.41.41.10.60.20.8-0.2-0.9-1.0-0.80.80.80.80.80.5-0.5-0.4-0.2-0.4
Reaction time false alarm rate1.62.33.81.1-1.1-1.6-1.8-1.50.71.41.60.51.5-1.8-1.7-1.7-1.6-2.01.61.71.41.5
Reaction time premature initiation rate0.81.03.2-1.31.31.31.7-1.31.81.1-1.10.2-1.20.80.40.20.50.30.40.30.90.7
Reaction time premature initiations0.50.62.2-1.01.01.21.5-0.50.90.3-1.1-0.2-1.11.00.70.60.80.7-0.2-0.30.2-0.0
Std. dev. reaction times1.42.03.2-1.81.81.71.10.90.7-0.8-1.8-1.6-1.71.51.61.61.61.2-1.3-1.1-0.9-1.1
Reaction time trials completed0.30.51.10.2-0.20.30.21.0-0.8-1.0-0.3-0.5-0.30.60.70.80.60.8-0.9-0.9-1.0-1.0
Reaction time trials AUC0.30.40.90.3-0.30.20.10.9-0.9-0.9-0.2-0.3-0.20.40.50.60.40.7-0.8-0.8-0.9-0.9
Run reversals in cocaine runway, females0.50.42.10.1-0.1-0.3-0.4-0.81.50.9-0.50.1-0.2-0.4-0.4-0.6-0.0-0.80.60.91.00.9
Run reversals in cocaine runway, males0.10.10.50.2-0.2-0.3-0.00.5-0.7-0.50.00.30.20.10.00.10.10.3-0.3-0.3-0.4-0.3
Latency to leave start box in cocaine runway0.40.41.10.7-0.7-0.7-1.0-0.4-0.00.50.60.20.8-0.9-0.7-0.7-0.9-0.90.60.60.40.5
Latency to leave start box in cocaine runway, F0.80.93.31.0-1.0-1.2-1.8-0.30.10.40.9-0.11.1-1.3-1.0-0.9-1.0-1.30.60.90.40.6
Latency to leave start box in cocaine runway, M0.20.21.3-0.40.40.61.1-0.0-0.10.0-0.70.3-0.30.60.40.40.20.6-0.1-0.3-0.1-0.1
Std. dev. time between licks in bursts0.10.10.40.5-0.5-0.3-0.10.5-0.1-0.6-0.1-0.0-0.20.10.10.10.50.3-0.3-0.3-0.2-0.2
Total sessions with >9 infusions0.00.00.1-0.40.40.10.30.2-0.0-0.2-0.1-0.1-0.20.30.20.20.30.3-0.2-0.2-0.1-0.1
Short access day 1 total inactive lever presses2.52.85.72.4-2.4-2.0-1.4-0.8-1.10.81.92.12.1-1.8-1.9-1.8-1.9-1.41.41.20.81.1
Short access day 10 total inactive lever presses0.20.31.20.2-0.2-0.20.4-0.80.50.80.21.10.0-0.2-0.4-0.5-0.3-0.30.60.50.70.6
Short access day 1 total infusions0.40.41.5-0.30.30.40.8-1.10.61.1-0.41.2-0.10.0-0.3-0.4-0.4-0.20.70.50.80.8
Short access day 10 total infusions0.20.20.7-0.50.50.20.4-0.70.80.7-0.40.1-0.40.1-0.1-0.20.1-0.20.30.40.60.5
Short access total infusions0.10.20.5-0.70.70.50.7-0.40.50.4-0.60.0-0.50.40.30.20.20.20.0-0.00.20.1
Short access day 1 locomotion0.80.92.6-0.70.70.91.0-1.61.61.6-0.80.8-0.50.1-0.2-0.4-0.3-0.40.80.81.21.0
Short access day 10 total locomotion2.32.611.2-0.40.40.51.5-2.71.32.80.03.3-0.0-0.3-1.1-1.3-1.2-0.81.81.52.01.8
Short access total locomotion1.61.75.5-1.61.61.62.4-1.71.81.7-1.31.4-1.30.90.3-0.00.40.30.60.51.20.9
One hour access (0.3 mA shock)0.10.10.3-0.20.2-0.10.2-0.50.40.50.10.5-0.1-0.0-0.2-0.2-0.0-0.20.30.30.40.3
Compulsive drug intake0.80.82.5-0.90.91.10.8-0.11.40.1-1.6-1.1-1.30.90.80.71.10.5-0.4-0.20.2-0.1
One hour access (shock baseline)0.30.31.60.2-0.2-0.5-0.1-0.4-0.50.41.01.30.6-0.4-0.6-0.5-0.7-0.30.50.40.20.3
Social response proportion0.80.92.60.7-0.7-1.0-0.7-0.5-1.00.41.61.21.4-1.0-1.1-1.0-1.2-0.70.80.60.30.5
Social responses0.70.94.31.1-1.1-1.3-1.00.6-2.1-0.71.20.81.4-0.8-0.7-0.5-0.9-0.20.0-0.2-0.7-0.3
Social time0.10.21.20.1-0.1-0.3-0.30.2-1.1-0.30.40.20.6-0.2-0.20.0-0.6-0.0-0.1-0.2-0.5-0.4
Soleus weight1.23.65.22.1-2.1-2.0-2.0-1.5-0.01.42.31.62.1-2.2-2.1-2.0-2.3-2.11.91.91.41.6
Bone: stiffness0.00.10.30.2-0.2-0.10.40.1-0.1-0.2-0.6-0.0-0.20.30.10.10.30.3-0.1-0.2-0.00.0
Tibialis anterior weight0.31.03.61.3-1.3-1.4-1.90.8-1.8-0.91.30.11.2-1.0-0.6-0.4-0.7-0.4-0.2-0.2-0.8-0.5
Time to tail flick, vehicle, before self-admin1.81.94.60.3-0.3-0.3-0.2-2.11.12.10.72.10.6-1.1-1.3-1.4-1.4-1.41.71.71.71.6
Time to tail flick, vehicle, after self-admin0.91.01.50.5-0.5-0.6-0.7-1.10.51.21.21.10.7-1.0-1.1-1.1-1.0-1.11.11.21.11.0
Time to tail flick, test, before self-admin2.72.64.4-1.51.51.51.31.8-0.2-1.7-1.2-2.1-1.51.81.81.81.91.8-1.7-1.7-1.5-1.6
Time to tail flick, test, after self-admin3.63.86.42.0-2.0-2.0-1.6-1.6-0.51.42.52.52.1-2.2-2.3-2.3-2.1-1.91.91.81.41.7
Delta time to tail flick, vehicle, before/after SA0.10.10.20.1-0.1-0.2-0.4-0.10.40.20.3-0.30.0-0.2-0.2-0.2-0.0-0.30.20.30.20.2
Delta time to tail flick, test, before/after SA3.63.25.61.9-1.9-1.9-1.5-1.5-0.51.41.82.42.0-2.0-2.1-2.0-2.1-1.81.81.61.31.5
Tibia length0.51.52.71.1-1.1-0.8-0.6-1.51.51.40.90.70.8-1.1-1.2-1.3-1.0-1.51.51.61.61.6
Ambulatory time before self-admin0.20.21.11.1-1.1-0.7-0.50.4-0.6-0.40.20.20.5-0.3-0.3-0.2-0.2-0.1-0.0-0.1-0.2-0.1
Ambulatory time after self-admin0.80.92.11.1-1.1-0.8-0.4-0.90.10.91.01.50.9-0.9-1.0-1.1-0.9-0.81.00.90.91.0
Bone: tissue strength2.02.03.1-0.80.80.90.81.6-1.1-1.6-1.0-1.4-1.11.41.51.61.41.7-1.7-1.8-1.8-1.8
Total heroin consumption0.10.10.4-0.20.20.4-0.00.1-0.4-0.10.7-0.2-0.00.10.20.4-0.20.1-0.2-0.2-0.4-0.5
Bone: trabecular number0.00.00.3-0.50.50.20.0-0.00.1-0.00.2-0.4-0.20.10.10.10.20.1-0.1-0.1-0.0-0.0
Bone: trabecular spacing0.30.41.21.1-1.1-0.9-1.00.2-0.6-0.00.60.50.7-0.8-0.6-0.6-0.6-0.60.30.30.00.2
Bone: trabecular thickness0.50.62.2-0.50.50.10.1-1.21.51.10.2-0.0-0.0-0.3-0.5-0.6-0.3-0.70.91.01.21.1
Bone: trabecular tissue density0.71.02.1-1.11.11.00.90.70.1-0.7-1.5-0.9-1.01.11.11.01.11.0-0.9-0.9-0.7-0.8
Water consumed over 24 hours0.80.93.2-0.10.1-0.1-0.41.5-1.8-1.60.0-0.90.10.30.50.70.60.9-1.1-1.2-1.5-1.3
Number of responses in last shaping day0.40.40.60.7-0.7-0.4-0.4-0.70.40.70.20.40.4-0.6-0.7-0.7-0.6-0.70.70.70.70.8