Hub : Genes

Tmed4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Tmed4 0.23 0.13 7.6e-12 0.06 0.15 0.14 0.15 1.4e-05 3.1e-12 9.3e-12 2.5e-12
2 NAcc mRNA stability Tmed4 0.06 0.03 7.1e-12 0.06 0.07 0.07 0.07 3.7e-10 2.5e-11 1.9e-10 2.1e-11
3 RMTg mRNA stability Tmed4 0.1 0.07 6.8e-03 0.04 0.07 0.05 0.04 3.7e-02 6.3e-03 2.2e-02 2.8e-02
4 Brain isoform ratio NM_001399064.1 0.06 0.03 2.4e-06 0.09 0.06 0.07 0.08 1.8e-08 4.2e-06 7.4e-07 9.2e-08
5 Brain isoform ratio NM_001399065.1 0.06 0.03 2.1e-06 0.09 0.06 0.07 0.08 1.5e-08 4.1e-06 5.0e-07 8.3e-08
6 Adipose gene expression Tmed4 0.1 0.06 1.4e-06 0.01 0.03 0.03 0.03 1.1e-02 1.7e-04 4.9e-04 3.2e-04
7 Liver gene expression Tmed4 0.34 0.13 0.0e+00 0.31 0.32 0.32 0.32 2.3e-35 1.2e-36 3.2e-36 1.8e-36
8 IC mRNA stability Tmed4 0.13 0.08 1.9e-04 0.02 0.02 0.01 0.04 4.1e-02 4.4e-02 7.7e-02 1.3e-02
9 BLA gene expression Tmed4 0.11 0.07 3.2e-03 0.07 0.06 0.05 0.06 1.5e-04 5.8e-04 1.0e-03 3.9e-04
10 Liver mRNA stability Tmed4 0.52 0.12 0.0e+00 0.34 0.34 0.34 0.34 1.7e-39 4.9e-39 1.4e-38 2.9e-39
11 Brain mRNA stability Tmed4 0.49 0.14 0.0e+00 0.35 0.36 0.37 0.36 2.6e-33 1.6e-35 9.3e-36 3.0e-35
12 PL mRNA stability Tmed4 0.28 0.13 2.2e-16 0.14 0.14 0.14 0.14 4.1e-15 1.2e-14 1.6e-14 3.5e-15
13 BLA mRNA stability Tmed4 0.15 0.08 6.5e-06 0.08 0.1 0.09 0.1 4.9e-05 3.5e-06 2.4e-05 7.3e-06
14 Adipose mRNA stability Tmed4 0.36 0.12 0.0e+00 0.26 0.29 0.29 0.29 3.5e-28 6.1e-32 3.7e-32 7.1e-32
15 LHb mRNA stability Tmed4 0.29 0.16 5.6e-04 0.13 0.07 0.15 0.12 5.5e-04 1.0e-02 2.4e-04 8.5e-04
16 Eye mRNA stability Tmed4 0.88 0.07 1.4e-05 0.17 0.15 0.27 0.15 1.3e-03 2.5e-03 5.2e-05 2.4e-03
17 IL gene expression Tmed4 0.32 0.17 1.7e-03 0.16 0.07 0.14 0.13 9.8e-05 7.2e-03 2.7e-04 4.5e-04
18 PL gene expression Tmed4 0.07 0.04 6.1e-05 0.04 0.04 0.04 0.04 1.5e-05 2.4e-05 1.6e-05 3.2e-05
19 NAcc gene expression Tmed4 0.18 0.07 0.0e+00 0.07 0.1 0.09 0.09 3.1e-11 4.4e-15 1.5e-13 1.8e-13
20 Brain gene expression Tmed4 0.29 0.12 0.0e+00 0.17 0.2 0.2 0.2 1.8e-15 1.2e-18 2.2e-18 9.2e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.00.00.10.1-0.10.20.3-0.30.30.10.00.1-0.20.20.00.0-0.10.0-0.10.20.10.20.3
Area under the delay curve3.03.57.1-2.7-2.4-2.3-1.91.9-0.0-2.5-2.11.2-1.3-1.8-2.2-2.3-2.4-1.9-1.70.41.21.51.4
BMI with tail0.10.31.4-1.2-0.8-0.8-0.10.1-0.7-0.6-0.8-0.2-0.0-0.4-0.3-0.5-0.4-0.7-0.20.5-0.1-0.20.7
BMI without tail0.30.92.0-1.3-1.4-1.0-0.90.9-0.8-1.1-1.30.2-0.5-1.1-1.1-1.2-1.2-1.0-0.7-0.30.10.40.6
Body weight1.14.710.5-3.2-3.2-2.9-2.62.6-1.4-2.7-2.50.3-0.6-2.5-2.5-2.4-2.4-2.5-1.20.50.40.81.7
Weight adjusted by age0.20.40.6-0.6-0.6-0.7-0.80.80.0-0.7-0.70.3-0.3-0.6-0.7-0.6-0.8-0.7-0.50.50.30.40.6
Bone surface0.10.10.3-0.1-0.3-0.3-0.30.3-0.40.00.2-0.50.5-0.00.00.1-0.00.00.4-0.5-0.3-0.3-0.2
Bone volume0.00.10.3-0.3-0.5-0.4-0.20.2-0.4-0.1-0.0-0.40.3-0.1-0.1-0.1-0.2-0.00.2-0.5-0.3-0.2-0.1
Breakpoint value in progressive ratio session0.20.30.8-0.7-0.6-0.8-0.50.5-0.3-0.6-0.70.0-0.0-0.6-0.6-0.4-0.4-0.7-0.20.60.00.00.9
Number of licking bursts1.11.74.9-2.1-2.0-2.2-1.81.8-0.7-1.5-1.1-0.00.2-1.2-1.3-1.2-1.6-1.4-0.30.2-0.60.20.8
Context. condit. distance diff. score1.82.23.91.82.01.71.7-1.71.11.81.7-0.70.71.81.81.81.71.81.1-0.6-0.4-0.7-1.4
Locomotion velocity, session 10.50.51.71.30.90.80.8-0.8-0.30.80.9-0.50.60.70.50.70.80.70.6-0.6-0.4-0.5-0.6
Locomotion distance, session 11.31.74.1-0.0-0.20.5-0.20.21.8-0.9-1.12.0-1.8-0.7-1.1-1.1-1.0-0.9-1.81.42.02.01.6
Locomotion velocity, session 21.61.93.11.81.20.70.9-0.9-1.21.41.7-1.61.71.01.01.41.51.31.7-1.7-1.1-1.5-1.5
Locomotion distance, session 20.30.41.71.20.81.30.7-0.70.90.50.30.7-0.60.40.30.20.30.3-0.40.20.70.60.2
Locomotion velocity, session 30.50.51.81.21.11.30.4-0.41.30.80.70.3-0.30.40.50.60.90.50.00.50.90.3-0.1
Locomotion distance, session 30.30.31.2-0.5-0.6-0.7-1.11.1-0.7-0.4-0.3-0.20.3-0.8-0.6-0.3-0.1-0.60.1-0.1-0.0-0.20.3
Stereotopy head waving bouts, day 30.20.21.11.00.51.10.5-0.50.40.40.30.5-0.40.10.10.10.30.1-0.30.30.60.40.1
Stereotopy head waving duration, day 31.21.43.92.01.72.01.7-1.70.91.41.20.1-0.01.31.11.11.21.10.30.30.2-0.0-0.5
Locomotion velocity, session 70.10.10.3-0.1-0.3-0.4-0.20.2-0.5-0.10.0-0.50.3-0.00.0-0.1-0.20.00.3-0.4-0.5-0.3-0.3
Locomotion distance, session 70.20.20.60.30.40.10.5-0.50.10.40.5-0.50.40.70.80.50.20.60.6-0.4-0.7-0.4-0.6
Stereotopy head waving bouts, day 70.10.20.50.60.50.30.1-0.10.30.40.7-0.30.40.20.20.50.70.30.5-0.30.3-0.2-0.4
Stereotopy head waving duration, day 70.10.10.60.30.20.3-0.20.20.40.00.20.2-0.2-0.3-0.3-0.10.2-0.1-0.20.20.80.40.1
Locomotion velocity, session 81.82.14.92.21.71.21.0-1.00.31.72.0-1.31.21.51.41.61.61.61.6-1.4-0.6-1.0-1.8
Locomotion distance, session 83.04.410.33.23.03.12.6-2.61.92.52.2-0.20.22.42.32.22.32.41.0-0.50.2-0.4-1.5
Degree of sensitization distance2.42.55.11.81.81.62.2-2.21.01.71.7-0.70.52.32.01.61.22.01.0-0.7-1.0-0.6-1.5
Degree of sensitization stereotypy0.00.00.10.00.0-0.1-0.40.40.1-0.00.3-0.10.2-0.2-0.20.00.3-0.10.1-0.30.3-0.0-0.2
Conditioned locomotion1.21.43.4-0.1-0.30.5-0.30.31.8-0.8-1.01.7-1.8-0.5-0.7-1.0-1.2-0.9-1.61.81.41.81.5
Cocaine response after cond. corrected0.70.92.2-1.2-1.3-1.5-1.41.4-0.5-1.0-0.8-0.10.2-1.1-1.0-0.9-0.9-1.1-0.10.50.20.20.9
Cocaine response after cond. not corrected1.21.42.9-1.7-1.6-1.7-1.61.6-0.3-1.4-1.20.3-0.1-1.5-1.4-1.2-1.2-1.4-0.50.80.40.41.2
Cocaine response before conditioning0.10.20.7-0.30.00.30.2-0.20.8-0.1-0.30.8-0.6-0.1-0.2-0.1-0.1-0.1-0.60.60.40.50.3
Saline control response0.30.40.80.90.70.60.4-0.4-0.00.70.8-0.60.60.40.50.70.80.60.7-0.8-0.3-0.5-0.8
Bone: connectivity density0.10.20.50.40.30.50.7-0.70.30.50.4-0.10.10.60.50.40.40.40.20.2-0.0-0.10.0
Bone: cortical apparent density0.20.20.5-0.7-0.5-0.7-0.70.7-0.7-0.4-0.2-0.30.3-0.6-0.5-0.3-0.1-0.40.1-0.4-0.0-0.2-0.1
Bone: cortical area1.52.34.3-2.1-2.0-1.8-2.12.1-0.7-1.8-1.70.5-0.6-2.0-1.9-1.7-1.5-1.8-1.00.30.80.81.1
Bone: cortical porosity0.10.10.60.10.10.10.8-0.8-0.20.1-0.2-0.20.10.50.30.1-0.20.10.20.2-0.4-0.10.2
Bone: cortical porosity0.10.20.60.10.20.30.8-0.80.50.1-0.30.3-0.30.50.3-0.0-0.30.1-0.20.60.00.30.4
Bone: cortical thickness1.42.24.4-2.1-1.9-1.6-1.71.7-0.4-1.8-1.90.7-0.8-1.8-1.8-1.7-1.6-1.7-1.20.81.00.91.4
Bone: cortical thickness0.60.83.4-0.5-0.60.30.1-0.11.8-0.4-0.81.1-1.10.0-0.3-0.5-1.0-0.3-0.91.31.11.31.0
Bone: cortical tissue density0.20.20.7-0.7-0.5-0.8-0.70.7-0.9-0.4-0.2-0.40.4-0.6-0.5-0.30.0-0.30.2-0.5-0.1-0.3-0.2
Condit. Reinf. active minus inactive responses0.60.72.8-0.5-0.6-1.1-0.60.6-1.7-0.20.1-1.11.1-0.3-0.3-0.1-0.0-0.20.8-1.4-1.3-0.9-0.8
Condit. Reinf. active-inactive response ratio2.52.74.80.91.10.01.1-1.1-1.51.41.6-2.12.11.41.41.71.71.42.1-2.1-2.2-2.2-2.0
Condit. Reinf. active responses0.30.31.0-0.4-0.7-0.8-0.80.8-1.0-0.4-0.1-0.50.4-0.4-0.5-0.4-0.5-0.40.3-0.8-0.8-0.3-0.4
Condit. Reinf. inactive responses1.01.32.3-1.0-1.2-0.9-1.31.30.4-1.3-1.10.9-1.0-1.2-1.3-1.3-1.5-1.3-1.00.90.71.21.0
Incentive salience index mean0.81.02.5-1.2-1.4-1.6-1.51.5-1.3-1.1-0.7-0.40.3-1.1-1.1-1.0-0.9-1.1-0.0-0.6-0.5-0.10.1
Condit. Reinf. lever presses1.82.53.8-1.5-1.7-1.1-2.02.00.2-1.8-1.71.3-1.3-1.8-1.8-1.9-1.8-1.9-1.61.11.21.61.5
Condit. Reinf. active minus inactive responses0.10.20.40.60.50.60.4-0.40.60.40.50.3-0.20.50.50.30.20.5-0.1-0.20.20.2-0.4
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.3-0.3-0.50.50.2-0.5-0.20.5-0.4-0.3-0.3-0.5-0.5-0.4-0.50.10.40.50.2
Condit. Reinf. active responses0.20.30.90.90.71.00.6-0.60.60.60.50.3-0.20.60.60.40.50.6-0.0-0.10.20.1-0.4
Condit. Reinf. inactive responses0.81.01.81.41.21.31.4-1.40.41.31.0-0.40.41.21.11.21.11.20.7-0.3-0.3-0.5-0.9
Condit. Reinf. lever presses0.10.10.60.40.30.50.3-0.30.80.30.50.1-0.10.60.30.30.10.50.0-0.30.30.2-0.5
Condit. Reinf. lever reinforcers received0.10.20.60.60.40.70.5-0.50.60.40.40.3-0.20.50.50.30.30.5-0.1-0.20.30.2-0.3
Conditioned reinforcement - actives0.10.10.4-0.3-0.50.0-0.30.3-0.4-0.2-0.30.2-0.2-0.5-0.3-0.3-0.2-0.1-0.2-0.70.20.1-0.2
Conditioned reinforcement - inactives0.20.31.0-0.6-1.0-0.6-0.90.9-0.5-0.5-0.50.0-0.0-0.7-0.5-0.5-0.6-0.3-0.2-0.70.00.10.0
Conditioned locomotion0.71.02.0-1.0-1.4-0.5-1.41.4-1.1-0.9-1.00.5-0.5-1.4-1.2-1.1-0.9-0.7-0.8-1.40.50.4-0.3
Patch foraging indifference point 0 sec1.12.15.4-1.2-1.2-2.3-1.01.0-2.1-0.30.3-2.22.2-0.3-0.10.30.20.01.7-2.1-2.1-1.9-1.2
Patch foraging indifference point AUC0.30.41.70.4-0.00.00.0-0.0-0.70.30.5-0.80.70.40.30.3-0.10.50.6-1.3-1.3-0.6-0.9
Delay disc. indifference point, 0s delay1.21.35.4-2.3-1.7-1.9-1.11.10.5-1.4-1.20.5-0.4-0.8-0.9-1.0-1.2-1.1-0.61.10.50.51.0
Delay disc. indifference point, 16s delay1.01.02.3-1.5-1.5-1.4-1.01.0-0.8-1.3-1.20.3-0.4-1.1-1.4-1.3-1.2-1.0-0.7-0.70.30.50.5
Delay disc. indifference point, 2s delay3.74.17.1-2.7-2.3-2.2-1.81.80.8-2.4-2.31.5-1.6-1.7-1.9-2.2-2.5-2.2-1.92.21.51.72.3
Delay disc. indifference point, 24s delay0.80.92.3-1.5-1.3-1.5-0.70.7-0.4-1.4-1.20.2-0.5-0.8-1.2-1.3-1.3-1.1-0.70.00.20.50.6
Delay disc. indifference point, 4s delay4.14.37.2-2.7-2.6-2.3-2.32.30.2-2.7-2.31.5-1.5-2.1-2.3-2.5-2.6-2.1-1.90.81.51.81.7
Delay disc. indifference point, 8s delay1.71.93.3-1.4-1.4-1.1-1.31.30.4-1.7-1.51.4-1.4-1.3-1.6-1.8-1.7-1.4-1.60.51.41.61.1
Indifference point function ln k0.40.72.4-0.8-0.5-0.2-0.20.20.6-0.8-0.91.0-1.1-0.6-0.9-0.8-0.9-0.9-1.11.60.71.01.2
Indifference point function log k0.40.72.4-0.8-0.5-0.2-0.20.20.6-0.8-0.91.0-1.1-0.6-0.9-0.8-0.9-0.9-1.11.60.71.01.2
Patch foraging total patch changes 0 sec1.32.45.9-1.2-1.1-2.3-1.01.0-2.3-0.20.4-2.42.4-0.2-0.00.40.20.21.9-2.4-2.4-2.1-1.4
Patch foraging total patch changes 12 sec1.31.74.9-0.7-0.5-1.4-0.20.2-1.90.20.6-2.12.00.30.50.60.40.51.6-2.1-2.2-1.9-1.4
Patch foraging total patch changes 18 sec1.82.810.8-0.5-0.7-1.8-0.90.9-2.30.21.0-2.62.60.10.50.80.70.82.1-3.3-1.9-2.3-2.2
Patch foraging total patch changes 24 sec2.44.17.91.51.30.61.3-1.3-0.72.02.3-2.52.31.92.12.22.12.32.6-2.8-1.8-2.3-2.8
Patch foraging total patch changes 6 sec1.32.05.8-1.0-1.1-2.0-0.90.9-2.4-0.20.2-2.22.1-0.3-0.10.20.1-0.01.6-2.2-2.2-1.8-1.0
Patch foraging time to switch 0 sec0.20.31.40.20.50.70.4-0.40.90.1-0.20.9-0.80.00.20.00.30.0-0.60.81.20.60.2
Patch foraging water rate 0 sec0.61.35.5-0.6-1.0-1.6-1.01.0-2.3-0.30.1-1.81.7-0.6-0.5-0.0-0.0-0.41.2-1.4-1.7-1.4-0.6
Patch foraging water rate 12 sec0.00.10.3-0.2-0.3-0.4-0.50.5-0.5-0.10.1-0.40.4-0.3-0.1-0.10.1-0.20.2-0.40.6-0.2-0.1
Patch foraging water rate 18 sec1.72.64.6-1.2-0.9-0.2-0.80.81.3-1.4-1.92.1-2.1-1.3-1.4-1.6-1.3-1.5-2.12.12.12.02.0
Patch foraging water rate 24 sec0.10.10.50.2-0.20.2-0.40.4-0.6-0.0-0.20.0-0.0-0.5-0.4-0.10.3-0.2-0.1-0.30.7-0.00.0
Patch foraging water rate 6 sec0.71.01.6-0.4-1.0-0.3-1.31.3-0.1-1.0-1.00.9-0.9-1.2-1.2-1.2-1.2-1.1-1.10.80.71.11.1
Seeking ratio, delayed vs. immediate footshock0.91.12.9-0.0-0.40.7-0.50.50.6-0.7-1.11.7-1.7-0.9-1.0-1.1-1.0-0.8-1.60.51.21.51.2
Distance traveled before self-admin0.10.20.40.20.0-0.2-0.50.5-0.40.20.4-0.60.6-0.10.30.20.40.10.5-0.1-0.6-0.4-0.4
Distance traveled after self-admin0.30.30.6-0.1-0.5-0.3-0.80.80.3-0.6-0.50.6-0.6-0.6-0.5-0.6-0.6-0.5-0.60.50.60.70.5
Extensor digitorum longus weight1.14.510.4-2.9-3.1-3.2-2.72.7-2.9-2.4-2.2-0.50.3-2.5-2.3-2.1-2.0-2.3-0.5-0.2-0.5-0.21.2
Bone: elastic displacement0.30.31.00.50.90.81.0-1.00.40.70.4-0.1-0.00.60.60.70.80.60.30.10.1-0.2-0.2
Bone: elastic work0.40.51.0-0.9-0.5-0.4-0.30.30.2-0.7-1.00.6-0.7-0.7-0.8-0.7-0.7-0.8-0.70.80.60.71.0
Bone: endosteal estimation0.00.00.3-0.0-0.2-0.3-0.50.50.0-0.10.1-0.00.1-0.1-0.1-0.1-0.2-0.00.1-0.4-0.00.1-0.2
Bone: endosteal perimeter0.71.53.3-1.3-1.4-1.1-1.81.80.0-1.4-1.20.9-0.8-1.5-1.4-1.4-1.4-1.3-1.10.21.01.00.8
Epididymis fat weight0.31.02.9-1.7-1.4-1.3-1.21.2-0.8-1.1-1.10.2-0.2-1.4-1.3-1.0-0.8-1.0-0.50.10.30.10.6
Delta time in closed arm before/after self-admin3.83.510.02.32.53.22.2-2.23.11.30.72.2-2.21.31.20.81.01.3-1.31.72.21.40.4
Delta time in open arm before/after self-admin2.82.78.2-2.1-2.0-2.6-2.22.2-2.9-1.0-0.5-1.81.8-1.6-1.1-0.6-0.6-1.31.0-1.0-1.8-1.4-0.1
Diff in mean of infusions in LGA sessions0.30.41.1-0.4-0.1-0.1-0.00.00.8-0.6-0.71.1-1.1-0.4-0.5-0.5-0.4-0.3-1.00.31.10.80.5
Delay discount exponential model param3.03.36.72.62.42.31.8-1.8-0.02.42.1-1.21.21.62.12.32.41.81.6-0.3-1.2-1.5-1.3
Extinction: sum of active levers before priming0.10.11.4-0.1-0.1-0.0-0.30.3-0.7-0.0-0.0-0.10.1-0.4-0.2-0.00.10.2-0.0-1.2-0.1-0.2-0.6
Active lever presses in extinction session 61.11.14.3-0.50.00.10.3-0.31.3-0.6-1.01.5-1.5-0.5-0.6-0.6-0.6-0.7-1.32.11.51.11.5
Bone: final force0.10.21.1-0.4-0.2-0.4-0.30.3-1.00.0-0.1-0.90.7-0.0-0.00.00.10.00.5-0.8-0.5-0.5-0.5
Bone: final moment0.20.21.2-0.6-0.4-0.6-0.40.4-1.1-0.2-0.2-0.80.6-0.2-0.2-0.1-0.0-0.10.4-0.7-0.5-0.5-0.3
Food consumed during 24 hour testing period0.60.84.4-0.1-0.5-1.0-0.30.3-2.1-0.10.3-1.51.4-0.2-0.20.10.2-0.11.0-1.4-1.0-1.2-0.7
Glucose7.511.750.20.1-0.8-3.0-1.01.0-7.10.62.0-5.25.10.20.61.21.51.04.1-5.7-4.9-4.9-3.7
Heart weight1.11.73.70.20.5-0.50.6-0.6-1.70.81.2-1.81.80.70.91.11.40.81.7-1.7-1.8-1.9-1.6
Delay discount hyperbolic model param3.43.87.12.72.52.41.9-1.9-0.12.62.2-1.31.41.82.22.42.62.01.8-0.6-1.3-1.6-1.5
Intermittent access intake day 1-15 change0.61.24.1-0.4-0.7-0.9-0.90.9-1.80.00.5-1.71.7-0.3-0.00.10.10.11.3-2.0-1.7-1.2-1.1
Intermittent access intake escalation0.51.03.6-0.5-0.7-0.9-0.90.9-1.7-0.10.3-1.51.5-0.3-0.10.0-0.10.01.1-1.8-1.9-1.0-1.0
Intermittent access intake escalation 20.91.03.90.3-0.3-0.4-0.50.5-1.30.50.8-1.71.70.20.50.60.40.41.5-1.5-2.0-1.2-1.0
Intermitt. access day 1 inactive lever presses0.10.21.20.20.00.60.0-0.00.8-0.0-0.20.9-0.9-0.00.0-0.2-0.20.2-0.70.01.10.70.1
Intermitt. access day 15 inactive lever presses0.61.24.4-1.2-1.5-1.3-1.41.4-2.1-0.6-0.3-1.31.3-1.0-0.7-0.5-0.6-0.70.8-1.2-1.3-0.8-0.3
Intermitt. access escalation Index1.11.64.30.10.1-0.40.3-0.3-1.30.81.0-2.02.00.80.71.00.90.71.8-2.1-1.9-1.6-1.4
Intermittent access day 1 total infusions0.50.81.9-0.1-0.7-0.1-0.20.21.0-0.8-1.01.4-1.4-0.5-0.7-0.9-1.1-0.6-1.20.91.21.31.0
Intermittent access day 15 total infusions0.50.82.0-1.0-1.4-1.3-1.11.1-1.3-0.8-0.6-0.60.6-0.9-0.8-0.6-0.8-0.60.3-1.1-1.0-0.3-0.2
Intermittent access terminal intake (last 3 days)0.50.72.4-0.4-0.9-0.8-0.60.6-1.2-0.10.2-1.21.2-0.2-0.10.1-0.2-0.00.9-1.5-1.6-0.8-0.7
Intermittent access total infusions0.30.41.4-0.7-1.2-0.8-0.60.6-0.6-0.7-0.70.0-0.0-0.6-0.7-0.6-0.8-0.6-0.2-0.6-0.30.20.1
Intermittent access day 1 locomotion1.31.65.80.60.11.00.1-0.11.2-0.6-1.12.4-2.4-0.6-0.8-1.0-0.9-0.3-2.10.42.31.90.7
Intermittent access day 15 total locomotion0.50.91.8-1.0-1.1-0.7-1.11.1-0.6-1.1-1.10.8-0.8-1.3-1.1-1.1-0.9-0.6-1.0-1.00.80.6-0.1
Intermittent access total locomotion0.91.01.6-0.8-1.2-0.7-1.11.1-0.4-1.2-1.21.0-1.0-1.3-1.3-1.3-1.1-0.8-1.2-0.81.00.90.2
Intermittent access standard deviation0.61.33.31.81.21.71.2-1.2-0.11.51.2-0.60.61.11.21.21.01.20.9-0.8-1.0-0.6-1.1
Left kidney weight0.41.93.4-0.9-1.0-0.5-1.21.20.7-1.4-1.51.5-1.7-1.4-1.3-1.5-1.2-1.4-1.71.71.91.51.6
Right kidney weight0.52.13.5-1.4-1.0-0.6-0.80.81.0-1.4-1.71.8-1.9-1.3-1.4-1.4-1.1-1.4-1.81.91.91.61.8
Cocaine induced anxiety0.91.34.0-1.5-1.3-1.7-1.41.4-2.0-1.0-0.9-0.70.7-1.4-1.2-0.8-0.7-1.10.2-0.9-0.7-0.60.2
Post-drug Anxiety1.21.34.0-2.0-1.5-2.0-1.31.3-1.3-1.3-1.2-0.30.3-1.3-1.3-1.0-0.9-1.2-0.1-0.5-0.3-0.30.6
Baseline Anxiety0.40.51.3-0.6-0.2-0.10.4-0.41.1-0.5-0.61.1-1.1-0.0-0.2-0.4-0.4-0.3-1.01.11.00.80.8
Tail length1.56.012.9-2.7-3.3-3.0-3.63.6-1.9-2.9-2.50.3-0.6-3.2-3.1-2.8-2.7-2.7-1.3-0.20.50.91.5
Length with tail1.46.213.4-3.0-3.4-3.3-3.73.7-1.8-3.0-2.50.2-0.4-3.1-3.1-2.8-2.7-2.7-1.20.10.40.91.5
Length without tail0.31.13.5-1.9-1.4-1.6-1.21.2-0.5-1.3-1.20.2-0.2-1.2-1.1-1.0-0.9-1.1-0.50.60.20.20.8
Times rat made contact with spout5.86.710.32.22.00.72.3-2.3-1.92.62.8-3.23.02.62.62.82.72.53.1-2.4-2.8-3.2-2.9
Lifetime Intake0.30.41.2-0.7-1.1-0.6-0.60.6-0.5-0.7-0.70.3-0.3-0.7-0.8-0.7-0.9-0.6-0.4-0.3-0.10.30.3
Liver weight, left0.30.61.60.40.40.90.6-0.61.30.0-0.51.1-1.20.30.1-0.2-0.4-0.0-0.91.20.71.10.8
Liver weight, right0.71.23.20.80.91.60.9-0.91.70.2-0.51.7-1.80.1-0.1-0.2-0.1-0.0-1.41.41.51.40.9
Locomotor activity0.81.23.60.2-0.1-0.6-0.10.1-1.60.60.8-1.61.80.50.80.90.50.51.5-1.5-1.9-1.6-1.1
Locomotor testing distance0.30.51.3-1.0-1.2-0.9-1.01.0-0.2-0.7-0.60.10.2-0.5-0.5-0.6-1.1-0.7-0.10.2-0.50.20.5
Locomotor testing rearing0.51.13.5-1.0-1.2-1.6-1.31.3-1.9-0.5-0.1-1.21.3-0.6-0.5-0.3-0.6-0.60.8-1.0-1.7-1.0-0.4
Locomotion in novel chamber1.21.66.90.81.81.21.7-1.72.61.00.80.8-0.81.41.41.11.11.3-0.11.20.80.3-0.2
Locomotion in novel chamber post-restriction0.81.23.81.41.51.81.3-1.32.00.90.71.1-1.11.10.90.70.71.0-0.50.71.10.7-0.2
Fecal boli incidents, locomotor time 10.10.20.70.40.50.60.4-0.40.20.2-0.10.4-0.4-0.0-0.10.00.1-0.2-0.30.90.40.20.7
Change in fecal boli incidents, locomotor task1.01.03.30.40.2-0.10.0-0.0-1.20.60.9-1.41.40.60.70.70.70.91.1-1.8-1.4-1.1-1.8
Time >=10cm from walls, locomotor time 10.10.10.40.00.50.30.6-0.60.60.40.2-0.0-0.10.40.40.50.60.50.2-0.2-0.0-0.1-0.3
Bouts of movement, locomotor time 11.01.13.5-0.6-0.8-1.0-0.10.1-0.80.40.7-1.51.80.60.70.70.50.81.5-1.9-1.4-1.3-1.3
Total resting periods, locomotor time 10.70.82.8-0.3-0.5-0.40.2-0.2-0.60.50.7-1.11.40.70.70.70.60.81.2-1.7-1.1-1.0-1.2
Rest time, locomotor task time 10.10.21.20.2-0.20.40.5-0.5-0.10.30.2-0.10.20.40.20.20.10.50.1-1.1-0.1-0.1-0.6
Distance moved, locomotor task time 10.30.40.8-0.5-0.3-0.5-0.90.9-0.5-0.7-0.70.4-0.7-0.9-0.8-0.8-0.5-0.8-0.70.20.40.40.4
Vertical activity count, locomotor time 10.00.10.2-0.2-0.1-0.3-0.40.4-0.3-0.2-0.2-0.20.0-0.3-0.2-0.2-0.2-0.4-0.00.5-0.2-0.10.3
Time >=10cm from walls, locomotor time 20.50.82.70.40.11.00.3-0.31.4-0.2-0.41.6-1.4-0.1-0.3-0.5-0.4-0.2-1.01.11.61.40.8
Bouts of movement, locomotor time 22.13.45.1-1.4-1.9-0.9-2.02.00.9-2.0-1.92.1-1.8-1.8-1.9-2.3-2.2-1.7-2.01.12.12.31.7
Total resting periods, locomotor time 21.52.54.1-1.3-1.8-1.0-1.91.90.5-1.9-1.61.6-1.4-1.5-1.7-2.0-2.0-1.5-1.60.51.61.91.3
Rest time, locomotor task time 20.50.71.40.50.60.40.8-0.8-0.60.80.8-0.91.00.70.70.80.90.80.8-1.2-0.9-0.9-0.9
Distance moved, locomotor task time 20.10.10.50.30.20.40.0-0.00.70.00.10.4-0.70.10.1-0.1-0.20.0-0.40.30.40.50.1
Vertical activity count, locomotor time 20.20.31.40.10.10.30.4-0.41.2-0.0-0.20.6-0.70.30.1-0.0-0.2-0.1-0.51.10.60.60.6
Light reinforcement 10.20.41.0-0.7-0.8-0.5-0.90.9-0.0-0.7-0.60.2-0.4-0.6-0.7-0.8-0.6-0.6-0.50.11.00.50.4
Light reinforcement 22.13.35.9-1.2-1.4-0.4-1.31.31.6-1.8-1.92.2-2.3-1.4-1.8-2.0-2.1-1.7-2.22.11.82.42.2
Bone: marrow area0.00.00.20.0-0.1-0.2-0.50.50.2-0.10.10.10.0-0.1-0.1-0.1-0.2-0.0-0.0-0.30.10.1-0.2
Bone: maximum diameter1.42.66.4-2.1-2.2-2.5-2.52.5-2.0-1.7-1.3-0.40.4-2.1-1.9-1.5-1.2-1.6-0.2-1.1-0.0-0.20.4
Bone: maximum force0.10.20.4-0.6-0.5-0.5-0.70.7-0.4-0.4-0.4-0.20.1-0.4-0.5-0.4-0.3-0.4-0.0-0.30.10.10.1
Bone: maximum moment0.20.30.6-0.7-0.7-0.7-0.80.8-0.5-0.6-0.6-0.10.0-0.6-0.6-0.5-0.4-0.6-0.1-0.20.10.10.2
Mean time between licks in bursts0.20.41.10.0-0.3-0.5-0.60.6-1.00.20.4-0.91.1-0.40.00.30.7-0.00.9-0.60.7-0.8-0.4
Mean num. licks in bursts3.96.19.53.12.82.23.0-3.0-0.62.92.7-2.01.72.72.72.73.12.72.2-1.7-1.2-2.2-2.5
Cd content in liver0.30.42.1-0.3-0.4-0.5-0.60.6-1.50.00.2-0.70.9-0.5-0.20.10.2-0.10.6-0.7-0.9-0.9-0.3
Co content in liver0.50.61.6-1.1-1.0-1.3-1.11.1-0.8-0.7-0.4-0.30.4-0.7-0.6-0.5-0.7-0.60.1-0.7-0.8-0.3-0.2
Cu content in liver0.20.21.00.30.1-0.20.0-0.0-1.00.30.4-0.70.70.10.20.40.40.10.6-0.5-0.4-0.8-0.4
Fe content in liver0.50.62.31.01.01.21.0-1.01.50.60.50.6-0.70.80.60.40.20.6-0.40.40.40.6-0.1
K content in liver3.93.75.2-2.0-2.0-1.3-2.02.00.3-2.1-2.31.6-1.5-2.3-2.2-2.1-1.8-2.2-1.91.72.21.72.2
Mg content in liver0.50.51.2-1.1-0.8-0.8-0.90.9-0.1-0.8-0.80.3-0.3-0.9-0.8-0.6-0.4-0.8-0.50.50.70.30.7
Mn content in liver0.70.81.3-0.5-0.7-0.3-1.11.10.1-0.9-0.91.0-0.7-1.1-1.2-1.1-1.0-1.1-1.00.70.31.01.0
Na content in liver1.31.43.6-1.9-1.8-1.9-1.51.5-0.8-1.4-1.1-0.10.0-1.2-1.1-1.2-1.2-1.3-0.30.20.40.20.8
Rb content in liver0.60.71.7-0.9-0.9-0.9-1.21.2-1.3-0.8-0.80.1-0.1-1.3-1.1-0.8-0.4-1.0-0.4-0.00.2-0.10.4
Se content in liver1.41.63.1-1.6-1.5-1.3-1.31.3-0.4-1.6-1.60.6-0.7-1.6-1.8-1.5-1.4-1.6-1.00.70.60.81.3
Sr content in liver2.01.86.1-2.3-1.8-2.5-1.51.5-1.0-1.7-1.3-0.00.0-1.5-1.3-1.4-1.1-1.4-0.50.10.30.10.8
Zn content in liver1.51.73.0-0.9-1.0-0.5-1.21.20.0-1.4-1.61.3-1.3-1.7-1.6-1.5-1.0-1.6-1.51.01.71.31.4
Bone: minimum diameter0.10.20.5-0.00.00.3-0.40.40.4-0.2-0.40.6-0.6-0.5-0.4-0.3-0.1-0.4-0.60.50.70.50.4
Time in familiar zone, hab. session 10.00.00.10.0-0.00.0-0.30.30.30.00.1-0.0-0.0-0.10.10.0-0.10.00.1-0.30.10.1-0.2
Time in novel zone, hab. session 10.10.10.50.10.1-0.20.4-0.4-0.70.20.1-0.50.50.10.10.30.50.10.4-0.1-0.5-0.6-0.1
Total zone transitions, hab. session 10.00.00.30.50.20.1-0.00.00.0-0.10.10.2-0.1-0.1-0.2-0.20.0-0.1-0.2-0.20.40.30.1
Total locomotion distance, hab. session 10.91.22.1-0.7-0.9-0.5-1.21.20.9-1.2-1.01.2-1.1-1.2-1.3-1.3-1.1-1.1-1.20.31.41.40.9
Locomotion velocity, hab. session 10.50.61.3-0.4-0.6-0.2-0.80.80.9-0.8-0.71.0-0.9-0.7-0.9-0.9-0.8-0.7-0.90.31.21.20.7
Time in familiar zone, hab. session 20.70.71.71.01.31.31.0-1.00.80.90.80.2-0.20.90.90.81.01.10.1-0.30.1-0.1-0.9
Time in novel zone, hab. session 20.50.52.6-0.6-1.0-1.2-0.60.6-1.6-0.5-0.3-0.90.9-0.6-0.7-0.3-0.4-0.60.5-0.2-0.8-0.70.3
Total zone transitions, hab. session 21.11.32.4-0.8-1.1-0.8-1.21.2-0.2-1.4-1.31.1-1.0-1.3-1.4-1.6-1.3-1.4-1.30.71.21.21.2
Total locomotion distance, hab. session 21.11.52.7-1.2-1.2-1.1-1.41.4-0.3-1.6-1.31.1-1.0-1.4-1.5-1.6-1.4-1.3-1.3-0.00.91.10.7
Locomotion velocity, hab. session 21.92.64.3-1.6-1.7-1.3-1.91.9-0.1-2.0-1.81.4-1.4-1.9-1.9-2.1-1.8-1.7-1.70.31.41.61.2
Novel to familiar place preference ratio0.20.20.70.40.0-0.20.0-0.0-0.80.20.5-0.70.80.10.10.30.30.30.6-0.8-0.4-0.5-0.5
Novelty place preference0.30.30.80.50.2-0.10.1-0.1-0.90.30.6-0.80.90.10.20.40.50.40.7-0.8-0.4-0.7-0.5
Time in novel zone, NPP test0.40.41.00.60.2-0.10.3-0.3-1.00.50.7-0.91.00.30.30.50.60.50.8-0.9-0.7-0.9-0.6
Total zone transitions, NPP test0.81.22.8-0.2-0.30.3-0.20.21.4-0.8-1.11.6-1.6-0.5-0.6-1.0-0.8-0.8-1.51.31.71.61.3
Total locomotion distance, NPP test1.62.13.9-1.1-1.1-0.2-0.90.91.4-1.4-1.61.9-1.9-1.1-1.3-1.6-1.5-1.3-1.91.41.82.01.7
Locomotion velocity, NPP test1.82.54.3-1.3-1.2-0.4-1.21.21.3-1.6-1.82.0-1.9-1.3-1.5-1.8-1.6-1.5-2.01.31.92.11.7
Intraocular pressure0.20.30.9-0.3-0.5-0.6-1.01.0-0.7-0.3-0.1-0.40.5-0.6-0.4-0.2-0.4-0.40.2-0.7-0.8-0.3-0.2
Delta distance traveled before/after self-admin0.50.51.70.30.10.60.4-0.41.3-0.2-0.51.3-1.30.1-0.2-0.4-0.50.1-1.00.71.31.10.6
Delta ambulatory time before/after self-admin0.50.61.70.30.20.50.6-0.61.3-0.2-0.51.2-1.20.2-0.1-0.3-0.4-0.0-0.91.01.21.00.9
Parametrial fat weight0.51.27.8-0.9-1.2-1.5-0.70.7-2.8-0.6-0.5-1.21.0-0.7-0.5-0.6-0.4-0.50.6-1.9-1.4-1.0-0.6
Pavlov. Cond. lever latency0.30.30.9-0.10.1-0.3-0.00.0-0.80.40.5-0.90.90.10.30.50.50.50.8-0.8-0.8-0.9-0.7
Pavlov. Cond. magazine entry latency0.50.72.01.31.11.41.0-1.01.21.00.80.1-0.11.00.90.80.70.80.30.40.20.1-0.4
Pavlov. Cond. change in total contacts0.70.71.6-0.6-1.1-1.2-1.31.3-1.2-0.9-0.6-0.30.2-1.0-1.1-0.9-0.7-1.0-0.1-0.4-0.10.10.2
Pavlov. Cond. index score0.30.41.60.80.71.10.6-0.61.30.40.10.7-0.70.40.30.20.10.2-0.40.70.70.70.2
Pavlov. Cond. latency score0.30.41.50.70.61.10.5-0.51.20.3-0.00.8-0.80.30.20.00.00.1-0.50.80.80.80.4
Pavlov. Cond. lever contacts0.30.30.90.30.10.60.1-0.10.8-0.2-0.30.9-1.0-0.1-0.1-0.4-0.4-0.3-0.80.70.80.90.5
Pavlov. Cond. magazine entry number0.70.92.3-1.5-1.2-1.4-1.01.0-0.7-1.2-1.00.3-0.3-1.1-1.0-1.0-0.9-1.0-0.60.20.10.30.7
Pavlov. Cond. intertrial magazine entries2.73.36.8-1.6-1.7-0.8-1.31.31.1-2.0-2.02.0-2.0-1.3-1.8-2.2-2.6-1.9-2.11.81.22.31.9
Pavlov. Cond. lever-magazine prob. diff.0.40.51.90.90.81.30.6-0.61.40.40.20.8-0.80.50.30.20.20.2-0.50.90.80.80.3
Pavlov. Cond. response bias0.10.10.50.60.30.70.1-0.10.70.10.00.4-0.50.0-0.0-0.0-0.0-0.1-0.30.40.60.60.2
Pavlov. Cond. lever latency3.64.98.1-2.7-2.4-2.2-2.62.6-0.6-2.6-2.71.3-1.3-2.8-2.6-2.5-2.2-2.7-1.81.61.31.42.4
Pavlov. Cond. magazine entry latency0.10.10.40.20.20.20.2-0.20.30.30.5-0.20.30.60.50.40.10.50.4-0.5-0.1-0.2-0.6
Pavlov. Cond. change in total contacts0.20.30.70.80.60.70.7-0.70.30.70.7-0.10.30.80.60.60.50.70.4-0.3-0.1-0.2-0.6
Pavlov. Cond. index score1.11.42.71.41.31.21.4-1.40.61.41.5-0.60.61.71.51.31.11.50.9-0.8-0.5-0.6-1.3
Pavlov. Cond. latency score0.91.22.51.41.21.31.3-1.30.81.31.3-0.30.41.61.31.20.91.40.7-0.5-0.3-0.4-1.1
Pavlov. Cond. lever contacts3.54.87.92.82.52.32.6-2.60.82.62.7-1.21.22.82.62.42.22.71.7-1.5-1.1-1.3-2.3
Pavlov. Cond. magazine entry number1.31.52.6-1.0-1.0-0.5-1.01.00.6-1.3-1.51.2-1.4-1.4-1.5-1.3-1.3-1.4-1.41.51.11.41.6
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.2-0.2-0.3-0.40.4-0.2-0.4-0.30.1-0.3-0.5-0.4-0.4-0.2-0.4-0.30.00.10.10.3
Pavlov. Cond. lever-magazine prob. diff.1.21.63.01.51.41.31.5-1.50.61.51.5-0.50.61.71.51.41.21.61.0-0.8-0.5-0.7-1.4
Pavlov. Cond. response bias2.83.76.02.32.01.72.0-2.00.32.22.4-1.41.42.52.32.11.82.41.8-1.8-1.3-1.4-2.2
Time in closed arm before self-admin0.10.10.4-0.2-0.7-0.4-0.10.1-0.3-0.4-0.60.1-0.1-0.1-0.6-0.5-0.7-0.5-0.20.00.10.30.5
Time in closed arm after self-admin0.91.03.11.20.91.61.2-1.21.80.50.11.3-1.30.90.40.10.10.7-0.90.31.31.10.2
Time in open arm before self-admin0.30.41.90.70.50.70.6-0.61.40.30.30.6-0.60.70.60.20.00.5-0.30.80.60.60.1
Time in open arm after self-admin0.30.41.7-0.2-0.3-0.4-0.90.9-1.30.00.2-0.90.9-0.5-0.00.10.2-0.30.6-0.0-0.9-0.7-0.3
Bone: periosteal estimation0.40.81.9-1.1-1.1-1.1-1.41.4-0.3-1.1-0.90.4-0.3-1.1-1.1-1.0-0.9-1.0-0.60.00.50.50.5
Bone: periosteal perimeter1.62.75.2-1.9-2.0-1.6-2.32.3-0.2-1.9-1.81.0-1.0-2.1-1.9-1.9-1.6-1.9-1.40.51.31.21.3
Bone: post-yield work0.00.10.1-0.2-0.3-0.3-0.30.30.3-0.3-0.00.1-0.0-0.2-0.3-0.2-0.2-0.2-0.1-0.20.30.20.0
Progressive ratio test 1 active lever presses0.60.71.6-0.4-1.1-0.4-0.50.50.0-1.0-1.11.0-1.0-0.7-1.0-1.1-1.2-0.8-1.00.20.61.10.8
Progressive ratio test 1 breakpoint0.60.81.7-0.4-1.1-0.4-0.60.60.0-1.0-1.11.0-1.0-0.8-1.1-1.1-1.3-0.8-1.10.10.61.10.7
Progressive ratio test 1 inactive lever presses3.34.87.5-2.1-2.7-1.7-2.42.4-1.2-2.5-2.61.6-1.6-2.7-2.7-2.6-2.6-2.6-2.11.11.51.62.1
Progressive ratio test 2 active lever presses0.30.31.4-0.8-1.2-0.9-0.70.7-0.3-0.5-0.5-0.30.3-0.5-0.4-0.4-0.6-0.40.1-0.7-0.30.00.1
Progressive ratio test 2 breakpoint0.20.31.2-0.7-1.1-0.9-0.70.7-0.3-0.5-0.4-0.40.4-0.4-0.3-0.3-0.5-0.30.2-0.7-0.4-0.00.1
Progressive ratio test 2 inactive lever presses0.81.43.2-1.3-1.8-1.0-1.31.3-0.6-1.4-1.40.9-0.9-1.4-1.4-1.4-1.4-1.0-1.1-0.80.90.90.4
Incentive Sensitization - Responses0.20.31.5-1.2-0.8-1.1-0.60.6-0.3-0.4-0.1-0.60.6-0.2-0.1-0.1-0.2-0.10.4-0.8-0.6-0.4-0.3
Incentive Sensitization - Breakpoint0.30.31.3-1.2-0.6-1.0-0.40.4-0.3-0.20.1-0.80.8-0.00.10.10.00.10.6-0.9-0.8-0.6-0.4
Sum of active levers in priming session hrs 5-61.11.02.2-1.4-0.8-1.0-0.80.8-0.0-1.1-1.20.8-0.8-1.1-1.1-0.9-0.8-1.2-0.91.40.80.61.5
Progressive ratio0.20.41.40.10.30.60.3-0.30.6-0.3-0.61.2-1.2-0.2-0.3-0.4-0.2-0.2-1.00.50.80.90.6
Food seeking constrained by brief footshock4.15.17.1-2.4-2.5-1.6-2.22.20.1-2.6-2.72.1-2.1-2.5-2.6-2.7-2.5-2.5-2.51.62.02.12.3
Seeking ratio, punishment vs. effort1.11.73.2-1.4-1.8-1.3-1.81.8-0.3-1.5-1.20.5-0.5-1.5-1.5-1.5-1.6-1.5-0.90.80.80.91.0
Retroperitoneal fat weight0.20.92.8-1.3-1.4-1.4-1.21.2-1.7-0.9-0.8-0.50.4-1.0-0.8-0.8-0.7-0.80.1-0.8-0.6-0.4-0.1
Reaction time number correct0.30.51.20.50.3-0.1-0.20.2-0.80.60.9-1.11.00.20.40.61.00.61.0-1.0-0.2-1.0-1.0
Reaction time mean minus median1.53.65.92.02.21.42.2-2.20.32.12.2-1.41.42.12.22.22.42.31.8-1.6-0.7-1.6-2.2
Reaction time mean minus median AUC1.12.84.11.71.81.21.9-1.90.51.92.0-1.41.32.02.02.02.02.01.7-1.0-0.6-1.4-1.8
Reaction time num false alarms0.91.32.9-1.7-1.5-1.4-1.41.4-0.2-1.3-1.40.5-0.4-1.2-1.2-1.2-1.3-1.3-0.70.90.40.51.3
Reaction time num false alarms AUC1.32.04.2-2.0-1.7-1.5-1.41.40.3-1.6-1.70.9-0.9-1.4-1.5-1.4-1.5-1.6-1.21.30.70.91.7
Reaction time trials correct on left0.30.51.20.50.3-0.1-0.20.2-0.80.60.9-1.11.00.20.40.61.00.61.0-1.0-0.2-1.0-1.0
Reaction time trials on left0.30.51.20.50.4-0.0-0.10.1-0.70.60.9-1.11.00.20.50.71.00.71.0-1.0-0.2-1.0-1.0
Reaction time mean0.30.52.00.61.10.91.4-1.40.80.70.50.2-0.20.80.80.70.80.80.1-0.2-0.2-0.1-0.5
Reaction time mean AUC0.40.72.40.71.21.11.5-1.51.10.80.50.4-0.40.90.80.70.80.8-0.00.10.20.1-0.4
Median of all reaction times0.20.31.10.20.60.71.0-1.00.80.2-0.10.8-0.70.30.20.10.10.2-0.50.20.10.50.1
Reaction time omissions0.60.92.30.81.20.81.5-1.50.71.00.9-0.30.41.31.21.11.01.10.7-0.4-0.7-0.5-0.7
Reaction time false alarm rate1.82.54.6-2.1-1.7-1.4-1.31.30.7-1.8-2.11.4-1.3-1.4-1.6-1.7-1.9-1.8-1.61.60.81.42.0
Reaction time premature initiation rate0.91.24.21.61.42.01.4-1.41.80.90.40.9-1.11.00.70.50.10.6-0.61.20.50.90.2
Reaction time premature initiations0.40.82.71.61.31.61.0-1.01.01.10.80.1-0.31.00.80.80.50.80.10.50.00.1-0.3
Std. dev. reaction times1.11.93.61.21.71.01.9-1.90.61.51.5-0.80.81.61.61.71.81.71.2-1.0-0.5-1.0-1.5
Reaction time trials completed0.30.51.20.50.4-0.0-0.10.1-0.70.60.9-1.11.00.20.50.71.00.71.0-1.0-0.2-1.0-1.0
Reaction time trials AUC0.20.41.00.40.2-0.1-0.30.3-0.70.40.7-1.00.90.00.30.50.90.50.9-0.9-0.0-0.9-0.8
Run reversals in cocaine runway, females0.40.42.2-0.2-0.30.0-0.10.11.5-0.3-0.20.9-0.90.10.0-0.3-0.60.1-0.70.51.01.00.1
Run reversals in cocaine runway, males0.10.10.40.0-0.3-0.1-0.20.2-0.7-0.00.1-0.20.2-0.2-0.1-0.1-0.0-0.10.1-0.30.2-0.2-0.3
Latency to leave start box in cocaine runway0.60.71.6-1.3-0.8-1.0-0.70.70.0-1.0-0.90.5-0.5-0.7-0.9-0.8-0.9-1.0-0.71.1-0.10.40.9
Latency to leave start box in cocaine runway, F1.41.64.8-2.2-1.5-1.8-1.21.2-0.0-1.5-1.40.5-0.5-1.1-1.3-1.3-1.4-1.5-0.81.6-0.00.61.3
Latency to leave start box in cocaine runway, M0.10.10.60.80.70.80.2-0.20.00.30.30.2-0.20.20.20.10.30.3-0.2-0.4-0.10.1-0.3
Std. dev. time between licks in bursts0.10.20.50.1-0.3-0.1-0.50.5-0.10.20.4-0.50.6-0.10.20.20.20.30.6-0.70.7-0.2-0.5
Total sessions with >9 infusions0.50.72.21.30.91.51.2-1.21.00.70.40.7-0.70.90.60.40.20.5-0.30.80.40.50.1
Short access day 1 total inactive lever presses1.41.84.5-1.2-1.8-1.3-2.12.1-1.6-1.4-1.40.2-0.2-2.0-1.6-1.4-1.4-1.6-0.7-0.10.30.40.9
Short access day 10 total inactive lever presses0.10.20.50.2-0.50.3-0.70.7-0.4-0.3-0.40.5-0.5-0.7-0.5-0.6-0.7-0.5-0.60.20.20.50.5
Short access day 1 total infusions0.50.62.21.30.81.50.8-0.80.90.40.11.2-1.20.30.20.00.10.4-0.90.41.20.90.1
Short access day 10 total infusions0.20.31.10.40.20.70.6-0.61.10.1-0.10.8-0.80.40.1-0.1-0.30.2-0.60.70.50.80.2
Short access total infusions0.10.10.30.3-0.00.40.2-0.20.2-0.0-0.20.5-0.5-0.0-0.1-0.1-0.3-0.2-0.40.50.30.40.4
Short access day 1 locomotion1.21.54.71.00.71.40.6-0.61.6-0.2-0.52.2-2.20.0-0.2-0.5-0.5-0.1-1.71.42.11.70.9
Short access day 10 total locomotion1.22.27.51.71.02.00.9-0.91.8-0.1-0.52.7-2.70.2-0.2-0.6-0.40.4-2.20.42.42.10.2
Short access total locomotion1.01.24.11.81.22.01.2-1.21.30.60.21.6-1.60.70.40.10.10.6-1.00.81.31.10.1
One hour access (0.3 mA shock)0.60.72.1-0.7-1.4-0.7-1.01.0-0.4-1.0-1.00.6-0.6-1.0-1.0-1.0-1.0-0.7-0.7-0.70.60.70.4
Compulsive drug intake0.60.72.00.91.40.91.0-1.01.40.90.80.1-0.11.01.10.90.81.10.20.10.1-0.1-0.5
One hour access (shock baseline)0.30.51.7-0.7-1.3-0.7-0.70.7-0.8-0.8-0.90.3-0.3-0.9-1.0-0.8-0.8-0.8-0.5-0.40.30.40.3
Social response proportion0.60.71.1-0.9-1.0-0.7-0.70.7-0.9-0.9-1.10.5-0.3-0.9-0.9-1.0-0.8-1.0-0.70.50.40.41.0
Social responses0.60.84.1-1.2-1.2-1.3-1.01.0-2.0-0.8-0.6-0.40.7-0.9-0.6-0.7-0.3-0.70.1-0.8-0.0-0.6-0.1
Social time0.10.11.0-0.4-0.1-0.30.1-0.1-1.0-0.1-0.2-0.30.3-0.3-0.1-0.00.4-0.10.1-0.40.3-0.5-0.2
Soleus weight1.44.06.0-2.3-2.3-1.6-2.22.20.1-2.2-2.41.5-1.5-2.4-2.3-2.2-2.0-2.4-1.91.71.81.62.3
Bone: stiffness0.10.10.30.60.20.50.1-0.10.10.40.4-0.10.20.30.30.30.20.40.3-0.5-0.2-0.0-0.5
Tibialis anterior weight0.41.34.6-1.9-1.8-2.2-1.31.3-1.6-1.2-1.0-0.60.7-1.1-1.0-0.8-0.8-0.90.2-0.8-0.7-0.50.1
Time to tail flick, vehicle, before self-admin1.51.53.9-0.4-0.50.1-0.50.50.7-1.1-1.42.0-2.0-1.1-1.2-1.3-1.0-0.9-1.90.92.01.61.2
Time to tail flick, vehicle, after self-admin0.30.41.0-0.5-0.4-0.1-0.20.20.6-0.6-0.71.0-1.0-0.5-0.7-0.7-0.6-0.5-0.90.41.00.90.6
Time to tail flick, test, before self-admin0.80.81.60.80.80.40.9-0.9-0.31.01.0-1.21.20.90.91.10.90.61.30.1-1.2-1.1-0.3
Time to tail flick, test, after self-admin2.72.84.3-1.3-2.0-1.4-2.02.0-0.7-2.0-1.91.0-1.0-2.0-2.0-2.1-2.0-2.0-1.40.81.01.31.8
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.10.10.10.4-0.40.70.10.10.2-0.20.40.20.10.00.1-0.00.60.20.20.2
Delta time to tail flick, test, before/after SA1.71.73.2-1.2-1.6-1.0-1.81.8-0.7-1.6-1.51.0-1.0-1.6-1.6-1.7-1.4-1.2-1.3-0.51.01.10.6
Tibia length0.71.84.1-1.1-1.0-0.1-0.90.91.6-1.0-1.51.4-1.6-0.9-1.1-1.2-1.4-1.3-1.42.01.51.71.9
Ambulatory time before self-admin0.20.31.1-0.5-0.6-0.7-1.11.1-0.5-0.3-0.0-0.40.4-0.6-0.2-0.2-0.1-0.30.3-0.2-0.4-0.2-0.2
Ambulatory time after self-admin0.40.40.90.1-0.3-0.0-0.60.60.5-0.5-0.60.9-0.9-0.6-0.4-0.6-0.6-0.5-0.80.90.90.90.8
Bone: tissue strength1.71.72.80.91.10.40.8-0.8-1.01.31.4-1.71.61.21.31.41.41.21.7-1.5-1.6-1.7-1.5
Total heroin consumption0.00.10.20.00.30.10.3-0.3-0.1-0.0-0.30.3-0.3-0.2-0.20.10.2-0.1-0.20.30.3-0.00.4
Bone: trabecular number0.00.00.10.0-0.10.10.3-0.30.10.1-0.00.1-0.00.1-0.00.10.1-0.00.00.40.00.00.3
Bone: trabecular spacing0.40.51.3-1.2-1.0-1.1-1.01.0-0.6-0.8-0.7-0.00.0-0.8-0.8-0.7-0.8-0.6-0.2-0.40.10.10.2
Bone: trabecular thickness0.40.52.40.20.10.70.4-0.41.6-0.2-0.31.0-1.20.2-0.1-0.3-0.5-0.0-0.90.61.01.20.5
Bone: trabecular tissue density1.01.42.51.41.50.81.4-1.40.11.21.5-0.70.81.41.41.21.31.51.0-1.3-0.7-0.8-1.6
Water consumed over 24 hours0.91.23.60.30.0-0.70.2-0.2-1.80.50.9-1.81.70.70.60.70.50.51.5-1.2-1.9-1.6-1.1
Number of responses in last shaping day0.40.41.50.3-0.10.4-0.20.20.6-0.3-0.41.0-1.0-0.4-0.3-0.5-0.5-0.2-0.90.61.20.90.5