Hub : Genes

Tmc6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	XM_039087492.2	0.02	0.02	1.5e-03	0.02	0.03	0.01	0.02	7.9e-03	7.2e-04	5.6e-02	9.2e-03
2	Brain	alternative TSS	XM_039087492.2	0.02	0.02	1.1e-03	0.02	0.03	0.02	0.02	5.1e-03	4.6e-04	8.2e-03	6.4e-03
3	Brain	isoform ratio	XM_039087492.2	0.02	0.02	1.6e-03	0.02	0.03	0.02	0.02	8.6e-03	4.8e-04	2.9e-03	4.7e-03
4	Liver	isoform ratio	NM_001398946.1	0.02	0.02	1.8e-03	0.01	0.01	0.01	0.01	8.0e-03	1.1e-02	1.1e-02	2.1e-02
5	IC	isoform ratio	XM_039087492.2	0.06	0.06	8.3e-03	0.05	0.04	0.06	0.05	4.5e-03	6.4e-03	1.1e-03	4.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.0	1.8	2.3	1.3	1.3	1.4	-1.5	1.1
Area under the delay curve	0.8	0.9	1.3	-1.0	-1.1	-1.1	0.6	0.9
BMI with tail	0.3	1.1	3.2	-0.7	-0.6	-0.4	1.0	-1.8
BMI without tail	0.4	1.2	2.3	1.0	1.0	1.1	-0.7	-1.5
Body weight	0.7	3.1	4.4	-1.8	-1.8	-1.7	2.1	-1.2
Weight adjusted by age	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.3	0.3
Bone surface	0.7	1.3	3.6	-0.9	-0.9	-0.9	0.7	1.9
Bone volume	0.5	0.9	4.4	-0.1	-0.1	-0.1	0.1	2.1
Breakpoint value in progressive ratio session	0.3	0.3	1.1	-0.4	-0.4	-0.2	1.0	0.3
Number of licking bursts	0.1	0.1	0.6	-0.2	-0.2	-0.2	0.0	0.8
Context. condit. distance diff. score	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.2
Locomotion velocity, session 1	0.4	0.4	0.7	-0.7	-0.7	-0.9	0.3	0.4
Locomotion distance, session 1	2.4	3.0	3.9	2.0	2.0	2.0	-1.7	-0.6
Locomotion velocity, session 2	0.6	0.7	0.8	0.9	0.9	0.9	-0.9	0.5
Locomotion distance, session 2	5.5	7.7	9.9	3.1	3.1	3.1	-3.0	-0.1
Locomotion velocity, session 3	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.2	0.2
Locomotion distance, session 3	0.8	0.8	3.3	0.4	0.4	0.4	-0.4	-1.8
Stereotopy head waving bouts, day 3	2.2	2.6	4.0	-1.8	-1.7	-1.7	2.0	0.5
Stereotopy head waving duration, day 3	2.2	2.6	3.5	-1.7	-1.7	-1.6	1.9	1.1
Locomotion velocity, session 7	0.1	0.1	0.3	0.3	0.2	0.2	-0.5	0.4
Locomotion distance, session 7	2.8	3.6	4.5	2.1	2.1	2.1	-2.1	0.2
Stereotopy head waving bouts, day 7	4.4	5.0	6.4	-2.5	-2.5	-2.5	2.4	0.2
Stereotopy head waving duration, day 7	5.7	6.8	8.6	-2.9	-2.9	-2.9	2.6	1.1
Locomotion velocity, session 8	0.5	0.6	1.0	-0.7	-0.7	-0.8	0.5	1.0
Locomotion distance, session 8	2.2	3.2	4.4	2.1	2.1	2.1	-1.7	-0.4
Degree of sensitization distance	3.7	3.8	3.9	1.9	2.0	1.9	-2.0	1.9
Degree of sensitization stereotypy	1.6	1.7	2.3	-1.5	-1.5	-1.5	1.3	-0.2
Conditioned locomotion	0.2	0.3	0.4	0.5	0.6	0.6	-0.4	0.6
Cocaine response after cond. corrected	0.3	0.3	0.8	-0.6	-0.5	-0.5	0.9	-0.2
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.5	0.2
Cocaine response before conditioning	0.4	0.5	0.9	0.5	0.5	0.4	-0.9	0.9
Saline control response	0.4	0.6	1.7	0.7	0.7	0.4	-1.3	0.0
Bone: connectivity density	1.5	2.3	4.3	1.5	1.5	1.5	-2.1	0.7
Bone: cortical apparent density	1.3	1.8	2.4	1.4	1.5	1.6	-1.3	-0.7
Bone: cortical area	3.5	5.3	8.6	-2.5	-2.5	-2.4	2.9	-0.6
Bone: cortical porosity	1.7	1.8	2.4	-1.5	-1.5	-1.5	1.1	0.8
Bone: cortical porosity	2.6	2.8	3.8	-1.9	-1.9	-1.9	1.4	0.9
Bone: cortical thickness	1.3	2.2	8.4	-0.7	-0.7	-0.6	1.0	-2.9
Bone: cortical thickness	0.4	0.5	2.1	-0.3	-0.3	-0.3	0.4	-1.4
Bone: cortical tissue density	1.3	1.8	2.5	1.5	1.5	1.6	-1.3	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.4	0.4	0.3	-0.4	0.6
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.4	0.4	0.4	0.4	-0.4	1.2
Condit. Reinf. active responses	0.6	0.8	1.0	1.0	0.9	0.9	-1.0	0.5
Condit. Reinf. inactive responses	0.7	0.8	1.1	1.0	1.0	0.9	-1.0	-0.3
Incentive salience index mean	0.1	0.1	0.5	0.2	0.2	0.1	-0.3	0.7
Condit. Reinf. lever presses	0.1	0.2	0.3	0.5	0.5	0.4	-0.5	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	-0.4	-0.5	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.1	-0.1
Condit. Reinf. active responses	0.2	0.3	0.4	0.5	0.5	0.5	-0.5	0.6
Condit. Reinf. inactive responses	0.8	1.1	1.3	1.1	1.1	1.1	-1.0	0.7
Condit. Reinf. lever presses	1.1	1.5	1.7	1.3	1.3	1.3	-1.2	1.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.6	0.6	0.7	-0.5	0.3
Conditioned reinforcement - actives	0.5	0.9	2.1	0.8	0.8	0.9	-0.4	-1.4
Conditioned reinforcement - inactives	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.1	-0.5
Conditioned locomotion	1.3	1.7	3.5	1.2	1.2	1.3	-0.8	-1.9
Patch foraging indifference point 0 sec	0.8	1.5	2.3	1.5	1.5	1.5	-0.9	-0.3
Patch foraging indifference point AUC	1.2	1.7	2.6	1.4	1.4	1.2	-1.6	-0.8
Delay disc. indifference point, 0s delay	0.6	0.6	1.1	-0.9	-0.9	-1.1	0.4	0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.4	0.4	0.4	-0.5	0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.6	-0.6	-0.6	0.1	-0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.1	0.1	0.1	-0.1	0.5
Delay disc. indifference point, 4s delay	0.9	1.0	1.5	-1.1	-1.1	-1.2	0.5	0.8
Delay disc. indifference point, 8s delay	3.2	3.8	5.2	-2.2	-2.2	-2.3	1.7	1.3
Indifference point function ln k	0.0	0.1	0.3	-0.2	-0.2	0.0	0.6	0.0
Indifference point function log k	0.0	0.1	0.3	-0.2	-0.2	0.0	0.6	0.0
Patch foraging total patch changes 0 sec	1.1	2.0	3.0	1.7	1.7	1.7	-1.1	-0.4
Patch foraging total patch changes 12 sec	3.8	4.9	5.9	2.4	2.4	2.3	-2.1	-1.7
Patch foraging total patch changes 18 sec	1.9	2.9	3.8	1.9	1.9	1.9	-1.7	-0.6
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	-0.2	-0.2	-0.3	0.4	-0.1
Patch foraging total patch changes 6 sec	1.9	2.9	3.5	1.9	1.9	1.8	-1.7	-1.0
Patch foraging time to switch 0 sec	0.2	0.3	0.5	-0.7	-0.7	-0.7	0.4	0.3
Patch foraging water rate 0 sec	0.5	1.0	1.6	1.2	1.2	1.2	-0.7	0.1
Patch foraging water rate 12 sec	0.1	0.3	0.6	0.6	0.6	0.8	-0.0	-0.3
Patch foraging water rate 18 sec	0.2	0.3	0.5	0.6	0.6	0.7	-0.3	0.6
Patch foraging water rate 24 sec	1.2	1.7	2.6	1.5	1.6	1.6	-1.1	0.4
Patch foraging water rate 6 sec	0.1	0.2	0.3	0.4	0.4	0.5	0.0	-0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.3	0.2	0.2	-0.7	-0.3
Distance traveled before self-admin	0.2	0.3	0.5	-0.6	-0.6	-0.7	0.2	-0.4
Distance traveled after self-admin	1.1	1.3	1.9	1.3	1.3	1.4	-1.1	-0.3
Extensor digitorum longus weight	1.1	4.2	5.5	2.3	2.3	2.4	-2.1	-0.8
Bone: elastic displacement	1.5	1.7	2.6	1.3	1.3	1.3	-1.0	-1.6
Bone: elastic work	0.6	0.8	2.1	-0.7	-0.7	-0.6	0.9	-1.4
Bone: endosteal estimation	1.9	4.1	9.3	-1.6	-1.6	-1.5	2.0	3.0
Bone: endosteal perimeter	5.6	11.8	12.3	-3.5	-3.4	-3.3	3.5	3.5
Epididymis fat weight	0.0	0.1	0.2	-0.2	-0.1	0.0	0.4	-0.4
Delta time in closed arm before/after self-admin	0.5	0.4	2.1	0.1	0.1	0.1	-0.2	1.5
Delta time in open arm before/after self-admin	0.9	0.9	1.3	1.0	1.0	1.0	-1.2	-0.3
Diff in mean of infusions in LGA sessions	1.1	1.4	2.2	-1.1	-1.1	-1.0	1.5	1.2
Delay discount exponential model param	1.1	1.2	1.7	1.2	1.2	1.3	-0.7	-1.0
Extinction: sum of active levers before priming	0.1	0.1	0.5	0.2	0.2	0.3	0.1	-0.7
Active lever presses in extinction session 6	0.2	0.2	1.0	0.2	0.2	0.3	0.3	-1.0
Bone: final force	1.2	1.9	2.5	-1.6	-1.6	-1.5	1.6	-0.1
Bone: final moment	1.4	2.2	2.9	-1.7	-1.7	-1.6	1.7	-0.1
Food consumed during 24 hour testing period	0.5	0.7	3.4	0.0	-0.0	-0.1	-0.3	1.8
Glucose	0.5	0.8	1.2	-1.1	-1.1	-1.0	0.8	-0.2
Heart weight	0.9	1.4	2.2	-1.0	-1.0	-0.9	1.4	-1.5
Delay discount hyperbolic model param	1.0	1.2	1.7	1.2	1.2	1.3	-0.7	-0.8
Intermittent access intake day 1-15 change	0.2	0.3	0.5	-0.6	-0.6	-0.7	0.2	0.6
Intermittent access intake escalation	0.1	0.2	0.3	-0.4	-0.4	-0.5	-0.0	0.5
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.4	-0.4	-0.4	0.0	0.5
Intermitt. access day 1 inactive lever presses	0.2	0.6	0.8	-0.8	-0.8	-0.8	0.9	0.5
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	0.5	0.5	0.5	-0.6	-0.1
Intermitt. access escalation Index	0.3	0.4	1.1	-0.5	-0.5	-0.6	0.3	1.0
Intermittent access day 1 total infusions	0.4	0.7	2.9	-0.1	-0.0	0.2	0.7	-1.7
Intermittent access day 15 total infusions	0.1	0.1	0.5	0.2	0.2	0.2	-0.1	-0.7
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	-0.5	-0.5	-0.4	0.6	-0.5
Intermittent access total infusions	0.3	0.3	0.7	-0.3	-0.3	-0.2	0.8	-0.8
Intermittent access day 1 locomotion	0.9	1.2	2.6	0.9	1.0	1.1	-0.5	-1.6
Intermittent access day 15 total locomotion	0.3	0.5	2.6	0.0	0.0	0.1	0.2	-1.6
Intermittent access total locomotion	0.5	0.6	2.5	0.3	0.3	0.5	0.1	-1.6
Intermittent access standard deviation	3.5	7.2	9.5	-3.0	-3.0	-2.9	3.1	0.1
Left kidney weight	1.2	5.4	7.5	-2.6	-2.6	-2.5	2.7	0.1
Right kidney weight	0.3	1.4	2.0	-1.3	-1.2	-1.2	1.4	-0.6
Cocaine induced anxiety	0.2	0.2	0.4	-0.5	-0.6	-0.6	0.2	0.4
Post-drug Anxiety	0.1	0.1	0.4	-0.0	-0.0	-0.1	-0.2	-0.6
Baseline Anxiety	0.3	0.3	0.6	0.5	0.5	0.6	-0.2	-0.8
Tail length	0.0	0.0	0.1	0.2	0.1	0.0	-0.3	0.2
Length with tail	0.9	4.1	5.3	-2.2	-2.2	-2.3	2.3	0.3
Length without tail	2.4	7.8	11.4	-3.1	-3.0	-2.9	3.4	-0.1
Times rat made contact with spout	0.5	0.6	1.1	0.6	0.6	0.6	-0.8	1.0
Lifetime Intake	0.3	0.4	0.9	-0.4	-0.4	-0.3	0.9	-0.7
Liver weight, left	1.3	2.2	2.8	-1.7	-1.7	-1.6	1.7	-0.1
Liver weight, right	0.9	1.6	2.2	-1.5	-1.5	-1.5	1.2	0.4
Locomotor activity	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	0.0
Locomotor testing distance	0.1	0.2	0.7	0.2	0.2	0.3	-0.1	0.8
Locomotor testing rearing	0.8	1.5	2.0	1.3	1.3	1.3	-1.4	0.8
Locomotion in novel chamber	0.6	0.8	1.7	0.7	0.7	0.6	-0.9	1.3
Locomotion in novel chamber post-restriction	0.6	1.0	3.7	-0.6	-0.5	-0.5	0.6	1.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.4	0.4	0.6	-0.1	0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	1.8	0.1	0.1	0.1	-0.1	-1.3
Time >=10cm from walls, locomotor time 1	0.4	0.4	2.0	-0.2	-0.2	-0.2	-0.3	1.4
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.1	0.1	0.2	-0.3	-0.5
Total resting periods, locomotor time 1	0.1	0.2	0.3	0.3	0.3	0.3	-0.5	-0.6
Rest time, locomotor task time 1	0.8	1.0	3.1	-0.7	-0.7	-0.6	0.7	-1.8
Distance moved, locomotor task time 1	0.3	0.4	1.0	0.5	0.5	0.4	-0.5	1.0
Vertical activity count, locomotor time 1	0.6	1.5	2.4	1.3	1.3	1.2	-1.5	0.4
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.9	0.5	0.5	0.5	-0.9	0.1
Bouts of movement, locomotor time 2	0.1	0.2	0.3	-0.5	-0.5	-0.4	0.5	0.2
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.5	-0.5	-0.4	0.5	0.2
Rest time, locomotor task time 2	0.7	0.9	1.2	-1.0	-1.0	-0.8	1.1	-0.8
Distance moved, locomotor task time 2	0.3	0.4	0.6	0.6	0.6	0.5	-0.8	-0.4
Vertical activity count, locomotor time 2	0.2	0.3	0.3	0.6	0.6	0.5	-0.5	-0.6
Light reinforcement 1	1.9	4.6	5.4	2.3	2.3	2.2	-2.1	-1.8
Light reinforcement 2	0.3	0.4	1.2	0.6	0.6	0.5	-0.4	-1.1
Bone: marrow area	1.9	4.0	9.0	-1.6	-1.6	-1.5	2.0	3.0
Bone: maximum diameter	8.2	15.2	19.2	-4.2	-4.2	-4.1	4.4	2.1
Bone: maximum force	1.4	2.4	3.8	-1.7	-1.7	-1.5	1.9	-0.0
Bone: maximum moment	1.5	2.7	4.4	-1.8	-1.8	-1.6	2.1	-0.0
Mean time between licks in bursts	0.1	0.2	1.1	-0.2	-0.2	-0.2	-0.2	1.0
Mean num. licks in bursts	0.4	0.6	0.9	0.9	0.9	0.9	-0.8	-0.2
Cd content in liver	0.9	1.0	1.7	1.2	1.2	1.3	-0.7	-0.2
Co content in liver	0.0	0.0	0.0	0.1	0.1	0.1	0.2	0.1
Cu content in liver	0.3	0.3	1.2	-0.3	-0.3	-0.3	0.5	1.1
Fe content in liver	0.1	0.1	0.3	-0.0	-0.0	-0.1	0.2	0.5
K content in liver	0.3	0.3	0.4	0.6	0.6	0.5	-0.6	0.0
Mg content in liver	2.4	2.5	3.2	1.8	1.8	1.7	-1.8	0.4
Mn content in liver	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.2	0.2
Na content in liver	0.1	0.1	0.7	0.0	0.0	-0.0	-0.0	0.8
Rb content in liver	1.6	1.8	2.5	1.5	1.5	1.5	-1.6	0.1
Se content in liver	0.9	1.1	1.5	1.2	1.2	1.1	-1.2	0.1
Sr content in liver	0.0	0.0	0.1	0.0	0.0	0.1	0.2	-0.3
Zn content in liver	0.1	0.1	0.4	-0.3	-0.3	-0.2	0.6	0.2
Bone: minimum diameter	3.4	6.2	7.7	-2.5	-2.5	-2.5	2.8	2.0
Time in familiar zone, hab. session 1	0.2	0.2	0.7	0.3	0.3	0.3	-0.2	-0.8
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.3	0.5
Total zone transitions, hab. session 1	1.8	2.5	3.2	1.8	1.8	1.8	-1.7	0.3
Total locomotion distance, hab. session 1	1.6	2.3	3.0	1.7	1.7	1.7	-1.7	-0.2
Locomotion velocity, hab. session 1	2.2	3.1	4.0	2.0	2.0	2.0	-1.8	0.1
Time in familiar zone, hab. session 2	0.3	0.3	1.3	0.2	0.3	0.3	0.0	-1.2
Time in novel zone, hab. session 2	0.5	0.5	0.8	-0.7	-0.7	-0.7	0.4	0.9
Total zone transitions, hab. session 2	5.3	6.8	9.0	2.9	3.0	3.0	-2.7	-0.2
Total locomotion distance, hab. session 2	5.5	7.2	9.3	3.0	3.0	3.1	-2.7	-1.1
Locomotion velocity, hab. session 2	5.6	7.5	9.6	3.1	3.1	3.1	-2.8	-1.1
Novel to familiar place preference ratio	1.8	1.9	2.8	1.6	1.6	1.7	-1.3	0.2
Novelty place preference	1.3	1.4	2.1	1.4	1.4	1.4	-1.1	0.3
Time in novel zone, NPP test	1.6	1.8	2.5	1.5	1.5	1.6	-1.3	0.1
Total zone transitions, NPP test	3.7	5.3	7.0	2.7	2.7	2.6	-2.2	-0.7
Total locomotion distance, NPP test	7.0	9.6	12.3	3.5	3.5	3.5	-3.1	-1.3
Locomotion velocity, NPP test	5.9	8.3	10.7	3.3	3.3	3.3	-2.8	-1.2
Intraocular pressure	0.2	0.3	0.6	0.7	0.7	0.8	-0.2	0.1
Delta distance traveled before/after self-admin	1.7	1.8	2.7	1.5	1.6	1.7	-1.2	-0.0
Delta ambulatory time before/after self-admin	1.7	2.1	3.2	1.7	1.7	1.8	-1.2	0.2
Parametrial fat weight	0.0	0.0	0.1	-0.0	-0.0	0.0	0.4	-0.3
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	-0.0
Pavlov. Cond. magazine entry latency	2.4	3.1	3.6	-1.8	-1.9	-1.9	1.7	1.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.5	0.5	0.6	-0.4	-0.1
Pavlov. Cond. index score	1.2	1.5	1.7	-1.3	-1.3	-1.3	1.3	0.9
Pavlov. Cond. latency score	1.5	1.9	2.3	-1.5	-1.5	-1.5	1.5	0.8
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.2	-0.2	-0.2	0.3	-0.2
Pavlov. Cond. magazine entry number	2.5	3.2	3.8	1.9	2.0	2.0	-1.9	-1.0
Pavlov. Cond. intertrial magazine entries	2.0	2.4	3.4	1.7	1.7	1.7	-1.9	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.1	-1.0	-1.0	-1.0	1.0	0.9
Pavlov. Cond. response bias	1.3	1.6	2.0	-1.4	-1.4	-1.4	1.4	0.7
Pavlov. Cond. lever latency	0.9	1.2	1.9	-1.0	-1.0	-1.0	1.1	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.4	0.5	0.6	-0.2	0.1
Pavlov. Cond. change in total contacts	0.7	1.1	1.5	1.1	1.1	1.2	-1.1	0.2
Pavlov. Cond. index score	0.5	0.7	0.8	0.8	0.8	0.9	-0.8	0.8
Pavlov. Cond. latency score	0.3	0.4	0.9	0.6	0.6	0.6	-0.6	0.9
Pavlov. Cond. lever contacts	1.3	1.8	1.9	1.4	1.4	1.4	-1.4	1.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.6	-0.6	-0.7	0.5	0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.9	4.2	0.4	0.4	0.3	-0.4	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.7	0.8	0.8	0.9	-0.8	0.8
Pavlov. Cond. response bias	1.0	1.4	1.8	1.3	1.3	1.4	-1.1	0.5
Time in closed arm before self-admin	0.5	0.7	3.2	-0.2	-0.2	-0.2	0.2	-1.8
Time in closed arm after self-admin	0.7	0.8	1.3	-0.9	-0.9	-0.8	1.1	-0.3
Time in open arm before self-admin	0.1	0.2	0.7	-0.1	-0.1	-0.1	0.1	0.8
Time in open arm after self-admin	0.7	0.7	0.9	0.9	0.9	0.9	-1.0	0.3
Bone: periosteal estimation	3.3	6.9	10.1	-2.7	-2.7	-2.6	3.2	1.8
Bone: periosteal perimeter	7.3	12.6	17.0	-3.9	-3.9	-3.8	4.1	1.3
Bone: post-yield work	0.2	0.3	0.4	0.5	0.5	0.6	-0.4	0.7
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	0.4	0.4	0.5	-0.1	-0.4
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	0.4	0.4	0.5	-0.1	-0.4
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2	-0.1
Progressive ratio test 2 active lever presses	0.4	0.5	1.0	0.7	0.7	0.8	-0.3	-1.0
Progressive ratio test 2 breakpoint	0.4	0.4	1.0	0.6	0.6	0.7	-0.2	-1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	-0.1	-0.1	-0.0	0.2	-0.7
Incentive Sensitization - Responses	0.3	0.4	0.6	-0.6	-0.5	-0.5	0.7	-0.7
Incentive Sensitization - Breakpoint	0.4	0.5	0.6	-0.7	-0.7	-0.6	0.8	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.3	-0.3	-0.1	0.4	-0.3
Progressive ratio	0.3	0.5	1.9	-0.1	-0.1	0.1	0.7	-1.4
Food seeking constrained by brief footshock	1.0	1.2	1.4	-1.2	-1.2	-1.1	1.2	-0.7
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	-0.5	-0.5	-0.6	-0.0	0.6
Retroperitoneal fat weight	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.0	0.4
Reaction time number correct	2.1	3.9	4.8	2.2	2.2	2.1	-2.1	1.0
Reaction time mean minus median	0.2	0.5	0.6	-0.7	-0.7	-0.7	0.8	-0.5
Reaction time mean minus median AUC	0.3	0.8	1.2	-1.0	-1.0	-1.1	1.0	-0.1
Reaction time num false alarms	0.1	0.2	1.0	0.1	0.1	0.1	0.2	-1.0
Reaction time num false alarms AUC	0.2	0.3	1.0	0.3	0.3	0.4	0.0	-1.0
Reaction time trials correct on left	2.1	3.9	4.8	2.2	2.2	2.1	-2.1	1.0
Reaction time trials on left	2.1	3.9	4.7	2.2	2.2	2.1	-2.1	1.0
Reaction time mean	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	-0.0
Reaction time mean AUC	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1
Median of all reaction times	0.0	0.0	0.1	-0.0	-0.0	0.0	-0.2	0.2
Reaction time omissions	0.9	1.3	2.1	-1.2	-1.2	-1.3	1.4	0.2
Reaction time false alarm rate	0.6	0.9	1.7	-0.8	-0.8	-0.7	1.0	-1.3
Reaction time premature initiation rate	3.0	4.2	5.3	2.2	2.2	2.3	-2.0	-1.4
Reaction time premature initiations	4.3	7.7	10.3	3.1	3.1	3.2	-2.8	-0.6
Std. dev. reaction times	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.2	-0.5
Reaction time trials completed	2.1	3.9	4.7	2.2	2.2	2.1	-2.1	1.0
Reaction time trials AUC	2.5	4.7	5.8	2.4	2.4	2.4	-2.3	0.9
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.5	-0.5	-0.5	0.6	-0.7
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.1	-0.1	-0.0	0.7	-0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.5	0.5	0.5	-0.1	-0.7
Latency to leave start box in cocaine runway, F	0.6	0.6	0.8	0.8	0.8	0.8	-0.6	-0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	0.2	0.3	0.2	0.0
Std. dev. time between licks in bursts	1.6	2.2	2.5	1.6	1.6	1.5	-1.6	1.0
Total sessions with >9 infusions	1.3	1.6	3.6	-1.2	-1.1	-0.9	1.9	-0.9
Short access day 1 total inactive lever presses	1.4	1.8	2.8	-1.5	-1.5	-1.4	1.7	0.3
Short access day 10 total inactive lever presses	0.3	0.8	1.2	-0.9	-0.9	-1.0	0.5	1.1
Short access day 1 total infusions	1.0	1.4	3.1	-1.2	-1.1	-1.0	1.8	-0.4
Short access day 10 total infusions	1.4	1.7	3.9	-1.3	-1.3	-1.1	2.0	-0.2
Short access total infusions	0.6	0.8	1.9	-0.8	-0.7	-0.6	1.4	-0.7
Short access day 1 locomotion	0.6	0.7	1.5	-0.7	-0.7	-0.6	1.2	-0.9
Short access day 10 total locomotion	0.5	0.9	1.6	-0.9	-0.9	-0.8	1.3	-0.7
Short access total locomotion	1.7	2.0	3.5	-1.4	-1.4	-1.2	1.9	-1.2
One hour access (0.3 mA shock)	0.4	0.4	0.8	0.6	0.6	0.7	-0.2	-0.9
Compulsive drug intake	0.4	0.4	0.5	0.7	0.7	0.7	-0.7	-0.2
One hour access (shock baseline)	0.0	0.1	0.2	-0.1	-0.1	-0.0	0.2	-0.4
Social response proportion	0.3	0.3	0.8	0.5	0.5	0.5	-0.3	-0.9
Social responses	0.2	0.2	0.3	0.4	0.4	0.3	-0.6	-0.6
Social time	0.2	0.2	0.3	0.6	0.6	0.6	-0.3	-0.4
Soleus weight	0.6	1.6	1.9	1.3	1.3	1.2	-1.4	-1.2
Bone: stiffness	1.2	2.0	2.7	-1.6	-1.6	-1.5	1.6	0.0
Tibialis anterior weight	0.1	0.5	0.6	0.7	0.7	0.8	-0.6	-0.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.6	0.5	0.5	-0.8	0.2
Time to tail flick, vehicle, after self-admin	1.1	1.5	1.8	-1.3	-1.3	-1.3	1.3	-0.6
Time to tail flick, test, before self-admin	0.9	0.9	1.6	1.0	1.0	0.9	-1.3	0.0
Time to tail flick, test, after self-admin	1.9	2.0	2.6	-1.6	-1.6	-1.6	1.4	0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.1	-0.9	-0.9	-0.9	1.0	-0.2
Delta time to tail flick, test, before/after SA	3.0	3.1	3.8	-2.0	-2.0	-1.9	2.0	0.2
Tibia length	11.4	31.3	42.1	-6.4	-6.4	-6.5	5.7	0.6
Ambulatory time before self-admin	0.5	0.8	1.3	-1.0	-1.1	-1.1	0.6	-0.4
Ambulatory time after self-admin	0.5	0.6	0.9	0.9	0.9	0.9	-0.6	-0.3
Bone: tissue strength	0.3	0.3	0.5	0.6	0.6	0.7	-0.2	-0.4
Total heroin consumption	2.6	3.0	4.5	-1.9	-1.9	-1.8	2.1	0.7
Bone: trabecular number	0.3	0.5	0.9	0.6	0.6	0.6	-1.0	0.9
Bone: trabecular spacing	0.2	0.2	0.6	-0.4	-0.4	-0.4	0.8	-0.0
Bone: trabecular thickness	0.5	0.6	1.5	0.5	0.5	0.6	-0.8	1.2
Bone: trabecular tissue density	0.1	0.1	0.4	-0.2	-0.2	-0.3	0.6	-0.3
Water consumed over 24 hours	0.3	0.5	0.7	0.7	0.7	0.6	-0.8	0.5
Number of responses in last shaping day	1.6	1.8	2.8	-1.5	-1.4	-1.3	1.7	-0.4