Hub : Genes

Tmc6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye mRNA stability Tmc6 0.36 0.23 2.0e-03 0.02 -0.02 -0.02 -0.01 1.4e-01 7.7e-01 7.3e-01 6.1e-01
2 Liver isoform ratio NM_001398946.1 0.02 0.02 1.7e-03 0.01 0.01 0.01 0.01 1.2e-02 1.7e-02 1.1e-02 2.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.01.71.8-1.31.4
Area under the delay curve1.82.02.21.3-1.5
BMI with tail0.20.81.4-0.41.2
BMI without tail1.63.43.8-1.91.7
Body weight0.31.21.81.3-0.8
Weight adjusted by age0.00.00.00.0-0.0
Bone surface0.30.50.60.7-0.7
Bone volume0.00.00.10.10.3
Breakpoint value in progressive ratio session0.30.30.6-0.10.8
Number of licking bursts0.00.10.10.2-0.2
Context. condit. distance diff. score0.00.00.0-0.2-0.1
Locomotion velocity, session 11.92.12.21.5-1.4
Locomotion distance, session 11.51.92.5-1.11.6
Locomotion velocity, session 20.30.40.4-0.60.6
Locomotion distance, session 24.46.26.7-2.42.6
Locomotion velocity, session 30.50.60.70.7-0.8
Locomotion distance, session 30.40.40.7-0.80.4
Stereotopy head waving bouts, day 31.21.51.81.3-1.1
Stereotopy head waving duration, day 31.51.82.41.6-1.1
Locomotion velocity, session 70.10.10.1-0.4-0.0
Locomotion distance, session 74.05.15.7-2.42.1
Stereotopy head waving bouts, day 72.83.23.21.8-1.8
Stereotopy head waving duration, day 75.87.17.52.7-2.6
Locomotion velocity, session 80.60.71.30.5-1.1
Locomotion distance, session 83.34.84.9-2.22.2
Degree of sensitization distance2.82.82.9-1.61.7
Degree of sensitization stereotypy1.21.41.41.1-1.2
Conditioned locomotion0.20.20.4-0.30.6
Cocaine response after cond. corrected0.00.00.10.2-0.2
Cocaine response after cond. not corrected0.10.10.10.3-0.3
Cocaine response before conditioning0.00.00.1-0.0-0.3
Saline control response0.60.81.40.2-1.2
Bone: connectivity density1.01.62.3-1.51.0
Bone: cortical apparent density2.02.62.7-1.61.7
Bone: cortical area1.62.43.31.8-1.2
Bone: cortical porosity2.62.83.21.8-1.6
Bone: cortical porosity3.43.74.22.1-1.8
Bone: cortical thickness0.00.00.00.20.0
Bone: cortical thickness0.00.00.10.30.0
Bone: cortical tissue density2.12.72.9-1.61.7
Condit. Reinf. active minus inactive responses0.00.10.1-0.30.2
Condit. Reinf. active-inactive response ratio0.20.20.2-0.50.4
Condit. Reinf. active responses0.10.20.2-0.40.4
Condit. Reinf. inactive responses0.20.20.3-0.30.5
Incentive salience index mean0.00.00.00.1-0.2
Condit. Reinf. lever presses0.10.10.10.40.0
Condit. Reinf. active minus inactive responses0.70.91.01.0-0.9
Condit. Reinf. active-inactive response ratio0.40.40.50.5-0.7
Condit. Reinf. active responses0.00.00.00.10.2
Condit. Reinf. inactive responses0.50.60.7-0.70.8
Condit. Reinf. lever presses0.81.11.3-0.91.1
Condit. Reinf. lever reinforcers received0.20.20.4-0.30.6
Conditioned reinforcement - actives1.21.21.5-1.01.2
Conditioned reinforcement - inactives0.10.10.20.2-0.5
Conditioned locomotion1.72.02.5-1.31.6
Patch foraging indifference point 0 sec0.81.31.8-0.91.4
Patch foraging indifference point AUC1.11.21.9-1.40.7
Delay disc. indifference point, 0s delay1.51.72.80.7-1.7
Delay disc. indifference point, 16s delay0.30.30.3-0.60.4
Delay disc. indifference point, 2s delay1.11.21.61.3-0.9
Delay disc. indifference point, 24s delay0.10.10.1-0.3-0.1
Delay disc. indifference point, 4s delay2.22.32.71.4-1.6
Delay disc. indifference point, 8s delay5.45.66.42.2-2.5
Indifference point function ln k0.20.30.50.30.7
Indifference point function log k0.20.30.50.30.7
Patch foraging total patch changes 0 sec1.22.02.7-1.11.6
Patch foraging total patch changes 12 sec3.24.14.8-2.21.9
Patch foraging total patch changes 18 sec1.62.02.2-1.51.3
Patch foraging total patch changes 24 sec0.20.20.40.3-0.6
Patch foraging total patch changes 6 sec2.03.03.8-1.91.5
Patch foraging time to switch 0 sec0.20.30.50.3-0.7
Patch foraging water rate 0 sec0.40.70.8-0.70.9
Patch foraging water rate 12 sec1.01.61.7-1.21.3
Patch foraging water rate 18 sec0.70.91.1-0.91.0
Patch foraging water rate 24 sec2.43.33.5-1.91.8
Patch foraging water rate 6 sec0.10.20.4-0.30.6
Seeking ratio, delayed vs. immediate footshock0.00.00.0-0.1-0.2
Distance traveled before self-admin1.92.12.71.2-1.6
Distance traveled after self-admin1.51.72.1-1.11.4
Extensor digitorum longus weight1.45.36.2-2.12.5
Bone: elastic displacement1.31.51.5-1.21.2
Bone: elastic work0.00.00.10.20.0
Bone: endosteal estimation0.51.22.11.5-0.4
Bone: endosteal perimeter3.47.18.93.0-2.3
Epididymis fat weight0.10.20.40.00.6
Delta time in closed arm before/after self-admin0.40.40.70.4-0.8
Delta time in open arm before/after self-admin0.80.80.9-0.90.8
Diff in mean of infusions in LGA sessions0.40.51.01.00.2
Delay discount exponential model param2.32.52.6-1.51.6
Extinction: sum of active levers before priming0.00.00.10.10.3
Active lever presses in extinction session 60.40.40.7-0.30.8
Bone: final force0.71.21.31.1-1.1
Bone: final moment0.81.21.31.1-1.1
Food consumed during 24 hour testing period0.20.20.4-0.2-0.7
Glucose0.20.30.4-0.60.4
Heart weight0.10.10.10.30.3
Delay discount hyperbolic model param2.22.42.4-1.61.5
Intermittent access intake day 1-15 change0.50.51.00.3-1.0
Intermittent access intake escalation0.30.30.60.1-0.8
Intermittent access intake escalation 20.10.10.1-0.3-0.2
Intermitt. access day 1 inactive lever presses2.22.42.61.5-1.6
Intermitt. access day 15 inactive lever presses0.10.10.2-0.40.3
Intermitt. access escalation Index0.90.81.10.7-1.1
Intermittent access day 1 total infusions0.10.20.20.30.5
Intermittent access day 15 total infusions0.00.00.00.1-0.2
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.3
Intermittent access total infusions0.00.00.10.30.1
Intermittent access day 1 locomotion1.01.01.4-0.81.2
Intermittent access day 15 total locomotion0.10.10.10.30.1
Intermittent access total locomotion0.40.50.8-0.50.9
Intermittent access standard deviation4.54.85.72.4-2.0
Left kidney weight2.36.56.62.6-2.5
Right kidney weight1.02.83.21.8-1.5
Cocaine induced anxiety0.70.91.60.4-1.3
Post-drug Anxiety0.20.20.2-0.4-0.5
Baseline Anxiety0.10.10.1-0.00.4
Tail length0.10.30.6-0.8-0.0
Length with tail1.24.55.02.0-2.2
Length without tail3.57.79.33.0-2.5
Times rat made contact with spout0.20.30.4-0.60.3
Lifetime Intake0.00.00.10.3-0.0
Liver weight, left2.13.43.81.7-1.9
Liver weight, right1.01.61.81.3-1.2
Locomotor activity0.10.10.20.50.2
Locomotor testing distance0.10.10.10.30.3
Locomotor testing rearing0.50.81.0-0.81.0
Locomotion in novel chamber0.30.30.6-0.80.2
Locomotion in novel chamber post-restriction0.00.00.0-0.0-0.2
Fecal boli incidents, locomotor time 10.80.91.6-0.41.3
Change in fecal boli incidents, locomotor task0.10.10.20.00.4
Time >=10cm from walls, locomotor time 10.10.10.30.0-0.5
Bouts of movement, locomotor time 10.10.10.10.30.3
Total resting periods, locomotor time 10.10.10.20.10.4
Rest time, locomotor task time 10.10.10.30.50.1
Distance moved, locomotor task time 10.10.10.3-0.5-0.1
Vertical activity count, locomotor time 10.70.70.9-0.90.7
Time >=10cm from walls, locomotor time 20.40.40.7-0.90.3
Bouts of movement, locomotor time 20.10.10.20.4-0.2
Total resting periods, locomotor time 20.10.10.10.4-0.1
Rest time, locomotor task time 20.60.71.51.2-0.1
Distance moved, locomotor task time 20.10.10.2-0.5-0.0
Vertical activity count, locomotor time 20.10.10.2-0.20.5
Light reinforcement 11.62.83.1-1.81.6
Light reinforcement 20.10.10.3-0.5-0.1
Bone: marrow area0.61.22.21.5-0.5
Bone: maximum diameter5.410.012.83.6-2.7
Bone: maximum force0.40.71.01.0-0.7
Bone: maximum moment0.40.81.01.0-0.7
Mean time between licks in bursts0.00.00.0-0.1-0.0
Mean num. licks in bursts0.70.80.8-0.90.9
Cd content in liver1.21.31.5-1.01.2
Co content in liver1.11.31.5-1.21.1
Cu content in liver0.00.00.10.3-0.1
Fe content in liver0.10.20.20.4-0.4
K content in liver0.10.10.2-0.1-0.4
Mg content in liver1.92.02.7-1.61.1
Mn content in liver0.91.01.60.7-1.3
Na content in liver0.60.71.00.6-1.0
Rb content in liver2.73.44.1-2.01.7
Se content in liver0.00.00.1-0.3-0.1
Sr content in liver0.00.00.0-0.1-0.1
Zn content in liver1.51.62.21.5-1.0
Bone: minimum diameter2.14.05.52.3-1.6
Time in familiar zone, hab. session 10.00.00.0-0.10.2
Time in novel zone, hab. session 10.30.30.60.1-0.8
Total zone transitions, hab. session 11.72.42.4-1.51.5
Total locomotion distance, hab. session 11.31.92.2-1.21.5
Locomotion velocity, hab. session 11.72.43.3-1.31.8
Time in familiar zone, hab. session 20.50.50.9-0.90.5
Time in novel zone, hab. session 20.60.60.60.8-0.7
Total zone transitions, hab. session 25.97.78.2-2.72.9
Total locomotion distance, hab. session 26.07.98.1-2.82.8
Locomotion velocity, hab. session 25.67.67.8-2.72.8
Novel to familiar place preference ratio3.13.23.5-1.71.9
Novelty place preference2.32.42.6-1.51.6
Time in novel zone, NPP test2.82.93.1-1.61.8
Total zone transitions, NPP test3.75.35.4-2.32.3
Total locomotion distance, NPP test6.99.510.7-2.93.3
Locomotion velocity, NPP test5.88.29.4-2.73.1
Intraocular pressure1.01.41.8-1.01.3
Delta distance traveled before/after self-admin3.84.25.3-1.72.3
Delta ambulatory time before/after self-admin4.54.95.7-2.02.4
Parametrial fat weight0.00.00.00.10.1
Pavlov. Cond. lever latency1.51.93.0-1.70.9
Pavlov. Cond. magazine entry latency3.74.75.62.4-2.0
Pavlov. Cond. change in total contacts0.30.30.50.10.7
Pavlov. Cond. index score2.63.34.52.1-1.5
Pavlov. Cond. latency score3.44.35.82.4-1.7
Pavlov. Cond. lever contacts0.60.71.31.1-0.3
Pavlov. Cond. magazine entry number3.94.95.8-2.42.0
Pavlov. Cond. intertrial magazine entries2.12.52.7-1.61.5
Pavlov. Cond. lever-magazine prob. diff.2.02.53.61.9-1.2
Pavlov. Cond. response bias2.42.94.12.0-1.3
Pavlov. Cond. lever latency1.01.42.00.9-1.4
Pavlov. Cond. magazine entry latency0.91.01.5-0.71.2
Pavlov. Cond. change in total contacts1.21.72.3-1.11.5
Pavlov. Cond. index score0.81.11.7-0.71.3
Pavlov. Cond. latency score0.50.71.1-0.51.1
Pavlov. Cond. lever contacts0.71.01.5-0.71.2
Pavlov. Cond. magazine entry number1.21.52.10.9-1.5
Pavlov. Cond. intertrial magazine entries0.10.10.20.3-0.4
Pavlov. Cond. lever-magazine prob. diff.1.01.31.9-0.81.4
Pavlov. Cond. response bias0.81.11.7-0.71.3
Time in closed arm before self-admin0.00.10.10.20.2
Time in closed arm after self-admin2.42.43.51.9-1.2
Time in open arm before self-admin0.40.40.40.6-0.6
Time in open arm after self-admin0.60.70.8-0.90.7
Bone: periosteal estimation1.53.25.02.2-1.2
Bone: periosteal perimeter4.67.79.43.1-2.4
Bone: post-yield work0.91.31.4-1.11.2
Progressive ratio test 1 active lever presses0.20.20.3-0.50.4
Progressive ratio test 1 breakpoint0.20.20.2-0.50.4
Progressive ratio test 1 inactive lever presses0.30.30.40.4-0.6
Progressive ratio test 2 active lever presses0.40.40.7-0.40.8
Progressive ratio test 2 breakpoint0.40.50.6-0.50.8
Progressive ratio test 2 inactive lever presses0.00.00.0-0.10.0
Incentive Sensitization - Responses0.40.40.70.8-0.4
Incentive Sensitization - Breakpoint0.60.60.90.9-0.6
Sum of active levers in priming session hrs 5-60.20.20.40.60.1
Progressive ratio0.20.30.40.40.6
Food seeking constrained by brief footshock1.11.42.41.6-0.6
Seeking ratio, punishment vs. effort0.50.70.90.6-1.0
Retroperitoneal fat weight0.20.70.91.0-0.8
Reaction time number correct3.85.47.1-2.71.9
Reaction time mean minus median0.70.90.91.0-0.9
Reaction time mean minus median AUC1.11.51.91.0-1.4
Reaction time num false alarms0.10.20.30.20.5
Reaction time num false alarms AUC0.20.30.7-0.10.8
Reaction time trials correct on left3.85.47.1-2.71.9
Reaction time trials on left3.75.37.0-2.61.9
Reaction time mean0.10.10.20.4-0.2
Reaction time mean AUC0.00.00.00.10.1
Median of all reaction times0.00.10.10.3-0.0
Reaction time omissions0.60.81.00.8-1.0
Reaction time false alarm rate0.60.81.61.2-0.3
Reaction time premature initiation rate3.24.34.7-2.02.2
Reaction time premature initiations7.09.910.1-3.23.1
Std. dev. reaction times0.10.10.20.4-0.2
Reaction time trials completed3.75.37.0-2.61.9
Reaction time trials AUC4.36.28.0-2.82.1
Run reversals in cocaine runway, females0.50.40.90.9-0.1
Run reversals in cocaine runway, males0.10.10.20.20.4
Latency to leave start box in cocaine runway0.70.70.9-0.80.9
Latency to leave start box in cocaine runway, F0.80.91.2-1.10.8
Latency to leave start box in cocaine runway, M1.31.32.0-0.71.4
Std. dev. time between licks in bursts1.41.72.2-1.51.1
Total sessions with >9 infusions0.20.20.30.5-0.4
Short access day 1 total inactive lever presses0.10.10.10.1-0.3
Short access day 10 total inactive lever presses1.21.31.90.8-1.4
Short access day 1 total infusions0.40.40.40.7-0.7
Short access day 10 total infusions0.60.71.11.0-0.6
Short access total infusions0.00.00.00.10.0
Short access day 1 locomotion0.10.10.10.4-0.3
Short access day 10 total locomotion0.10.10.20.4-0.3
Short access total locomotion0.20.30.30.6-0.4
One hour access (0.3 mA shock)0.40.40.6-0.40.8
Compulsive drug intake0.60.60.9-0.61.0
One hour access (shock baseline)0.00.00.00.1-0.1
Social response proportion0.40.40.8-0.10.9
Social responses0.00.00.0-0.00.1
Social time0.60.81.1-0.71.0
Soleus weight0.51.61.6-1.31.3
Bone: stiffness1.11.82.21.5-1.1
Tibialis anterior weight0.10.50.7-0.60.8
Time to tail flick, vehicle, before self-admin0.20.30.3-0.40.6
Time to tail flick, vehicle, after self-admin0.91.01.51.2-0.6
Time to tail flick, test, before self-admin0.00.00.0-0.20.1
Time to tail flick, test, after self-admin0.30.30.40.7-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.10.3-0.0
Delta time to tail flick, test, before/after SA0.50.50.60.6-0.7
Tibia length13.738.739.56.3-6.2
Ambulatory time before self-admin3.23.33.71.7-1.9
Ambulatory time after self-admin0.50.60.6-0.80.8
Bone: tissue strength1.71.61.7-1.31.2
Total heroin consumption1.41.72.01.4-1.1
Bone: trabecular number0.10.20.3-0.50.4
Bone: trabecular spacing0.30.40.60.8-0.4
Bone: trabecular thickness0.50.70.8-0.70.9
Bone: trabecular tissue density0.50.71.21.1-0.4
Water consumed over 24 hours0.20.20.4-0.7-0.1
Number of responses in last shaping day1.92.02.41.6-1.3