Tmbim6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Tmbim6	0.05	0.04	1.9e-06	0.04	0.06	0.06	0.05	1.0e-04	2.3e-06	7.8e-06	1.6e-05
2	Liver	isoform ratio	XM_006257323.4	0.09	0.07	5.5e-10	0.07	0.08	0.08	0.08	1.6e-08	2.5e-09	5.7e-09	4.0e-09
3	Adipose	mRNA stability	Tmbim6	0.13	0.1	2.5e-13	0.1	0.11	0.1	0.1	2.4e-11	8.7e-12	1.2e-11	1.6e-11
4	Liver	isoform ratio	NM_019381.2	0.1	0.08	2.3e-10	0.08	0.08	0.08	0.08	4.0e-09	1.5e-09	4.6e-09	3.2e-09
5	PL	intron excision ratio	chr7_130527706_130535190	0.02	0.02	1.4e-03	0.02	0.01	0.01	0.01	6.3e-03	1.6e-02	2.1e-02	2.2e-02
6	PL	alternative TSS	XM_039078437.1	0.02	0.02	4.5e-03	0.01	0.02	0.01	0.02	8.2e-03	5.4e-03	1.0e-02	6.5e-03
7	Liver	alternative polyA	NM_019381.2	0.13	0.1	5.1e-15	0.13	0.12	0.12	0.13	4.8e-14	9.4e-14	1.2e-13	4.4e-14
8	Adipose	gene expression	Tmbim6	0.33	0.27	2.6e-15	0.12	0.12	0.12	0.12	1.1e-13	6.4e-13	5.5e-13	2.1e-13
9	Brain	gene expression	Tmbim6	0.04	0.04	1.5e-03	0.04	0.03	0.04	0.04	1.3e-04	3.7e-04	1.9e-04	1.7e-04
10	Liver	alternative polyA	XM_039078436.1	0.12	0.09	6.9e-14	0.12	0.12	0.12	0.12	1.9e-13	6.8e-13	4.5e-13	5.2e-13
11	PL	intron excision ratio	chr7_130527799_130535190	0.04	0.04	4.4e-03	0.02	0.02	0.02	0.02	2.5e-03	2.2e-03	2.5e-03	2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	9.8	16.4	18.8	4.3	4.2	4.3	-4.2	4.1	-4.2	-3.7	-4.3	-3.5	-3.4	4.1
Area under the delay curve	1.0	1.1	1.5	1.0	1.1	1.0	-1.0	1.2	-1.0	-1.1	-1.0	-1.2	-1.0	0.9
BMI with tail	4.4	14.1	15.2	3.9	3.9	3.9	-3.9	3.8	-3.7	-3.8	-3.6	-3.7	-3.7	3.4
BMI without tail	0.1	0.1	0.5	-0.0	-0.0	-0.0	0.0	0.3	0.2	-0.5	0.3	-0.7	-0.7	-0.4
Body weight	5.8	24.3	26.3	5.1	5.1	5.1	-5.1	5.1	-5.0	-4.6	-4.9	-5.0	-4.3	4.8
Weight adjusted by age	1.3	1.5	2.4	1.2	1.2	1.3	-1.3	1.4	-1.4	-0.6	-1.4	-1.1	-0.4	1.5
Bone surface	11.9	20.9	22.9	4.8	4.8	4.8	-4.8	4.6	-4.7	-4.4	-4.8	-4.1	-4.1	4.5
Bone volume	9.7	16.4	17.7	4.2	4.2	4.2	-4.2	4.1	-4.0	-4.1	-4.1	-3.9	-3.9	3.8
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.4	0.5	0.5	-0.5	0.5	-0.5	-0.2	-0.4	-0.5	-0.1	0.6
Number of licking bursts	1.1	1.3	2.7	-1.0	-1.0	-1.0	1.0	-1.4	0.9	1.2	0.8	1.6	1.2	-0.7
Context. condit. distance diff. score	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	0.5	-0.5	-0.4	-0.5	-0.4	-0.4	0.5
Locomotion velocity, session 1	2.1	2.3	4.4	-1.4	-1.4	-1.4	1.4	-1.5	1.1	2.0	1.1	1.9	2.1	-0.8
Locomotion distance, session 1	2.8	3.5	4.0	-1.9	-1.9	-1.9	1.9	-1.9	1.8	2.0	1.9	1.8	1.9	-1.7
Locomotion velocity, session 2	0.2	0.3	0.4	-0.5	-0.5	-0.5	0.5	-0.5	0.5	0.6	0.4	0.6	0.6	-0.4
Locomotion distance, session 2	2.6	3.6	4.4	-1.9	-1.9	-1.9	1.9	-1.9	1.8	2.1	1.7	2.0	2.1	-1.6
Locomotion velocity, session 3	4.5	5.3	6.0	-2.3	-2.4	-2.3	2.3	-2.4	2.2	2.4	2.1	2.4	2.3	-2.0
Locomotion distance, session 3	4.3	4.7	5.7	-2.3	-2.3	-2.3	2.3	-2.2	2.4	1.9	2.2	1.7	1.8	-2.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.8	0.9	0.9	0.9	-0.9	0.5	-1.1	-0.3	-1.3	-0.3	-0.1	1.3
Stereotopy head waving duration, day 3	0.3	0.4	1.0	0.6	0.6	0.6	-0.6	0.3	-0.8	-0.0	-0.9	0.1	0.2	1.0
Locomotion velocity, session 7	1.1	1.2	3.3	-1.0	-1.0	-0.9	1.0	-1.2	0.6	1.7	0.4	1.3	1.8	-0.3
Locomotion distance, session 7	2.7	3.5	5.4	-1.9	-1.9	-1.8	1.9	-1.9	1.6	2.3	1.4	1.9	2.3	-1.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	1.0	0.9	0.9	-0.9	0.8	-0.9	-0.9	-1.1	-0.8	-0.9	0.9
Stereotopy head waving duration, day 7	1.2	1.4	1.7	1.2	1.2	1.2	-1.2	1.1	-1.2	-1.3	-1.2	-1.1	-1.2	1.1
Locomotion velocity, session 8	0.1	0.1	0.6	-0.2	-0.2	-0.1	0.1	-0.4	-0.0	0.6	0.0	0.7	0.7	0.2
Locomotion distance, session 8	1.2	1.7	2.0	-1.4	-1.3	-1.3	1.3	-1.3	1.3	1.4	1.3	1.3	1.3	-1.1
Degree of sensitization distance	0.2	0.2	0.6	0.5	0.5	0.5	-0.5	0.4	-0.6	-0.1	-0.7	-0.1	0.0	0.8
Degree of sensitization stereotypy	0.3	0.4	0.9	0.5	0.5	0.5	-0.5	0.6	-0.3	-0.9	-0.3	-0.8	-1.0	0.2
Conditioned locomotion	0.0	0.0	0.2	0.1	0.1	0.1	-0.1	-0.2	-0.2	0.1	-0.2	0.4	0.1	0.2
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	0.1	0.0	-0.0	0.0	-0.4	-0.0	-0.1
Cocaine response after cond. not corrected	0.4	0.4	0.6	-0.7	-0.7	-0.7	0.7	-0.5	0.7	0.5	0.7	0.3	0.5	-0.8
Cocaine response before conditioning	3.1	3.7	4.1	-2.0	-2.0	-2.0	2.0	-1.9	2.0	1.7	2.0	1.9	1.5	-2.0
Saline control response	0.1	0.1	0.3	0.3	0.3	0.3	-0.3	0.0	-0.4	0.0	-0.5	0.5	0.1	0.5
Bone: connectivity density	6.4	10.1	12.8	3.4	3.4	3.4	-3.4	3.1	-3.5	-2.7	-3.6	-2.4	-2.4	3.5
Bone: cortical apparent density	0.2	0.3	0.3	-0.6	-0.6	-0.6	0.6	-0.5	0.6	0.5	0.5	0.2	0.5	-0.6
Bone: cortical area	8.1	12.2	14.2	3.7	3.7	3.7	-3.7	3.5	-3.7	-3.2	-3.8	-3.0	-2.9	3.7
Bone: cortical porosity	0.3	0.3	0.8	-0.5	-0.5	-0.5	0.5	-0.4	0.7	-0.0	0.8	0.1	-0.2	-0.9
Bone: cortical porosity	0.5	0.6	1.2	-0.8	-0.8	-0.8	0.8	-0.6	1.0	0.2	1.0	0.3	0.1	-1.1
Bone: cortical thickness	2.5	4.1	5.2	2.1	2.1	2.2	-2.1	1.9	-2.2	-1.7	-2.3	-1.6	-1.5	2.2
Bone: cortical thickness	0.1	0.1	0.4	-0.0	-0.0	0.0	-0.0	-0.2	-0.2	0.5	-0.3	0.6	0.6	0.4
Bone: cortical tissue density	0.3	0.4	0.5	-0.7	-0.7	-0.7	0.7	-0.6	0.7	0.6	0.6	0.3	0.6	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.3	0.2	0.3	0.2	0.2	0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.5	0.5	0.5	-0.5	0.5	-0.6	-0.4	-0.6	-0.4	-0.3	0.6
Condit. Reinf. active responses	0.7	0.8	1.0	-0.9	-0.9	-0.9	0.9	-1.0	0.9	1.0	0.8	0.9	1.0	-0.8
Condit. Reinf. inactive responses	2.9	3.5	3.8	-1.9	-1.9	-1.9	1.9	-1.9	1.9	1.9	1.9	1.8	1.8	-1.8
Incentive salience index mean	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	-0.0	-0.1	-0.1	0.0	0.1
Condit. Reinf. lever presses	0.2	0.3	0.8	0.5	0.5	0.4	-0.5	0.6	-0.3	-0.7	-0.3	-0.9	-0.8	0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	1.3	0.3	0.3	0.2	-0.2	0.2	0.0	-1.0	0.1	-0.4	-1.1	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.1	-0.1	-0.1	-0.2	0.2	-0.1	0.5	-0.8	0.6	-0.3	-1.0	-0.9
Condit. Reinf. active responses	0.1	0.1	0.4	-0.2	-0.2	-0.3	0.3	-0.2	0.4	-0.3	0.4	0.0	-0.4	-0.6
Condit. Reinf. inactive responses	0.6	0.8	1.1	-0.9	-0.9	-0.9	0.9	-0.8	0.9	1.0	0.8	0.7	1.0	-0.8
Condit. Reinf. lever presses	0.0	0.0	0.1	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.0	-0.1	0.3	-0.0	0.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	-0.6	-0.6	-0.7	0.7	-0.7	0.8	0.2	0.8	0.6	0.1	-0.9
Conditioned reinforcement - actives	1.6	1.6	2.1	-1.3	-1.3	-1.3	1.3	-1.1	1.4	1.1	1.5	1.0	1.0	-1.4
Conditioned reinforcement - inactives	2.3	2.6	3.0	-1.7	-1.7	-1.7	1.7	-1.6	1.7	1.5	1.7	1.5	1.4	-1.6
Conditioned locomotion	0.4	0.4	0.8	-0.7	-0.7	-0.7	0.7	-0.7	0.7	0.5	0.9	0.5	0.4	-0.7
Patch foraging indifference point 0 sec	4.2	6.7	10.9	-2.5	-2.5	-2.4	2.5	-2.7	2.1	3.2	2.0	3.1	3.3	-1.6
Patch foraging indifference point AUC	0.3	0.4	0.7	-0.6	-0.6	-0.6	0.6	-0.8	0.6	0.4	0.5	0.8	0.3	-0.7
Delay disc. indifference point, 0s delay	1.6	1.7	2.6	1.3	1.3	1.3	-1.3	1.2	-1.2	-1.6	-1.1	-1.4	-1.6	1.0
Delay disc. indifference point, 16s delay	0.9	0.9	1.4	1.0	1.0	1.0	-1.0	1.0	-0.9	-0.9	-0.8	-1.2	-0.8	0.8
Delay disc. indifference point, 2s delay	1.9	2.1	2.9	1.4	1.4	1.4	-1.4	1.7	-1.3	-1.5	-1.4	-1.5	-1.5	1.2
Delay disc. indifference point, 24s delay	1.0	1.0	1.2	1.1	1.1	1.1	-1.1	1.1	-1.1	-0.8	-1.1	-0.9	-0.7	1.1
Delay disc. indifference point, 4s delay	0.7	0.7	1.4	0.8	0.8	0.7	-0.7	0.9	-0.6	-1.1	-0.6	-1.1	-1.2	0.4
Delay disc. indifference point, 8s delay	2.1	2.1	2.6	1.5	1.5	1.5	-1.5	1.6	-1.5	-1.2	-1.5	-1.4	-1.0	1.5
Indifference point function ln k	4.7	6.6	7.6	2.6	2.6	2.6	-2.6	2.8	-2.5	-2.6	-2.4	-2.8	-2.5	2.3
Indifference point function log k	4.7	6.6	7.6	2.6	2.6	2.6	-2.6	2.8	-2.5	-2.6	-2.4	-2.8	-2.5	2.3
Patch foraging total patch changes 0 sec	3.9	6.3	10.1	-2.4	-2.4	-2.4	2.4	-2.6	2.0	3.1	1.9	3.1	3.2	-1.6
Patch foraging total patch changes 12 sec	4.1	5.3	8.2	-2.2	-2.3	-2.2	2.2	-2.5	1.9	2.8	1.8	2.6	2.9	-1.5
Patch foraging total patch changes 18 sec	6.1	7.8	11.1	-2.7	-2.8	-2.7	2.8	-3.1	2.5	3.1	2.3	3.3	3.0	-2.2
Patch foraging total patch changes 24 sec	3.6	4.4	6.2	-2.0	-2.1	-2.0	2.0	-2.3	1.8	2.4	1.6	2.5	2.4	-1.5
Patch foraging total patch changes 6 sec	4.6	6.9	10.5	-2.5	-2.6	-2.5	2.5	-2.7	2.2	3.2	2.0	3.2	3.2	-1.8
Patch foraging time to switch 0 sec	2.3	3.5	3.9	-2.0	-2.0	-1.9	1.9	-1.8	1.9	2.0	1.8	1.7	1.9	-1.7
Patch foraging water rate 0 sec	2.9	4.7	5.6	2.2	2.2	2.2	-2.2	2.1	-2.1	-2.4	-2.1	-2.1	-2.3	1.9
Patch foraging water rate 12 sec	3.4	5.2	6.2	2.4	2.4	2.4	-2.4	2.1	-2.4	-2.2	-2.5	-1.7	-2.0	2.4
Patch foraging water rate 18 sec	0.3	0.4	0.7	0.6	0.6	0.6	-0.6	0.7	-0.6	-0.6	-0.5	-0.8	-0.6	0.5
Patch foraging water rate 24 sec	4.1	5.6	7.4	2.4	2.4	2.4	-2.4	2.4	-2.2	-2.7	-2.2	-2.3	-2.7	1.9
Patch foraging water rate 6 sec	4.6	6.7	8.5	2.6	2.6	2.6	-2.6	2.6	-2.4	-2.9	-2.4	-2.7	-2.9	2.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.8	0.7	0.7	0.7	-0.7	0.5	-0.5	-0.9	-0.5	-0.3	-0.9	0.4
Distance traveled before self-admin	1.5	1.6	2.6	-1.3	-1.3	-1.3	1.3	-1.2	1.1	1.6	1.1	1.0	1.6	-0.9
Distance traveled after self-admin	0.3	0.3	0.5	-0.5	-0.6	-0.5	0.6	-0.7	0.5	0.7	0.4	0.4	0.7	-0.3
Extensor digitorum longus weight	4.3	16.8	19.7	4.2	4.2	4.1	-4.2	4.3	-3.9	-4.4	-3.6	-4.4	-4.3	3.5
Bone: elastic displacement	5.0	5.7	7.5	-2.4	-2.4	-2.4	2.4	-2.4	2.1	2.7	2.2	2.7	2.7	-1.8
Bone: elastic work	0.0	0.1	0.1	0.2	0.2	0.2	-0.2	0.4	-0.3	0.0	-0.2	-0.3	0.0	0.3
Bone: endosteal estimation	8.1	17.6	19.1	4.4	4.4	4.4	-4.4	4.3	-4.3	-4.2	-4.2	-3.8	-3.9	4.0
Bone: endosteal perimeter	6.8	14.1	15.4	3.9	3.9	3.9	-3.9	3.7	-3.7	-3.9	-3.7	-3.4	-3.7	3.5
Epididymis fat weight	0.1	0.2	0.5	0.5	0.5	0.5	-0.5	0.3	-0.6	-0.3	-0.7	-0.1	-0.2	0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	0.1	-0.5	-0.3	-0.5	-0.2	-0.2	0.5
Delta time in open arm before/after self-admin	4.3	4.2	5.0	-2.1	-2.1	-2.1	2.1	-2.0	2.1	1.9	2.1	2.2	1.7	-2.0
Diff in mean of infusions in LGA sessions	1.7	1.8	2.7	1.4	1.4	1.4	-1.4	1.6	-1.4	-1.1	-1.3	-1.5	-1.0	1.4
Delay discount exponential model param	1.0	1.1	1.5	-1.0	-1.0	-1.0	1.0	-1.2	0.9	1.0	0.9	1.2	1.0	-0.8
Extinction: sum of active levers before priming	0.7	0.7	0.9	0.8	0.8	0.8	-0.8	0.9	-0.8	-0.8	-0.7	-1.0	-0.8	0.7
Active lever presses in extinction session 6	0.3	0.3	0.5	0.6	0.6	0.6	-0.6	0.5	-0.7	-0.3	-0.6	-0.4	-0.2	0.7
Bone: final force	11.1	17.9	19.3	4.4	4.4	4.4	-4.4	4.4	-4.2	-4.3	-4.1	-4.1	-4.1	3.9
Bone: final moment	12.2	19.8	21.3	4.6	4.6	4.6	-4.6	4.6	-4.4	-4.6	-4.3	-4.4	-4.4	4.0
Food consumed during 24 hour testing period	1.7	2.0	2.3	1.5	1.5	1.5	-1.5	1.4	-1.4	-1.4	-1.5	-1.3	-1.3	1.4
Glucose	0.1	0.2	1.1	-0.1	-0.1	-0.1	0.1	-0.5	-0.1	0.6	-0.1	1.0	0.7	0.3
Heart weight	0.1	0.1	0.2	0.3	0.3	0.3	-0.3	0.3	-0.3	-0.3	-0.2	-0.4	-0.3	0.3
Delay discount hyperbolic model param	1.1	1.1	1.6	-1.0	-1.0	-1.0	1.0	-1.3	0.9	1.1	0.9	1.3	1.1	-0.8
Intermittent access intake day 1-15 change	1.1	1.1	2.2	-1.1	-1.1	-1.1	1.1	-1.0	1.3	0.4	1.3	0.5	0.2	-1.5
Intermittent access intake escalation	0.7	0.7	1.7	-0.8	-0.8	-0.9	0.9	-0.7	1.1	0.1	1.1	0.1	-0.1	-1.3
Intermittent access intake escalation 2	1.1	1.1	2.5	-1.1	-1.1	-1.1	1.1	-0.9	1.4	0.3	1.4	0.4	0.1	-1.6
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.7	-1.3	-1.3	-1.3	1.3	-1.0	1.5	0.7	1.6	0.6	0.5	-1.6
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.5	-0.9	-0.9	-0.9	0.9	-0.7	1.1	0.3	1.2	0.2	0.2	-1.2
Intermitt. access escalation Index	0.4	0.4	0.8	-0.6	-0.6	-0.6	0.6	-0.5	0.4	0.8	0.3	0.9	0.8	-0.3
Intermittent access day 1 total infusions	1.3	1.5	1.7	-1.3	-1.3	-1.3	1.3	-1.0	1.2	1.3	1.3	1.1	1.2	-1.1
Intermittent access day 15 total infusions	2.6	2.9	3.6	-1.8	-1.8	-1.8	1.8	-1.6	1.9	1.5	1.9	1.3	1.3	-1.9
Intermittent access terminal intake (last 3 days)	2.8	3.0	3.8	-1.9	-1.9	-1.9	1.9	-1.6	1.9	1.4	1.9	1.3	1.2	-1.9
Intermittent access total infusions	2.6	2.8	3.5	-1.8	-1.8	-1.8	1.8	-1.5	1.9	1.4	1.9	1.3	1.3	-1.9
Intermittent access day 1 locomotion	1.1	1.2	1.9	-1.1	-1.1	-1.1	1.1	-1.0	0.9	1.4	1.0	1.1	1.4	-0.8
Intermittent access day 15 total locomotion	1.7	1.9	2.5	-1.4	-1.4	-1.4	1.4	-1.4	1.4	1.2	1.6	1.2	1.1	-1.4
Intermittent access total locomotion	3.9	4.5	4.8	-2.2	-2.2	-2.2	2.2	-2.1	2.1	2.2	2.2	2.1	2.1	-1.9
Intermittent access standard deviation	0.3	0.3	0.9	-0.6	-0.6	-0.6	0.6	-0.4	0.8	0.1	0.8	-0.1	-0.0	-1.0
Left kidney weight	0.7	2.0	5.2	1.2	1.2	1.2	-1.2	1.6	-1.0	-1.6	-1.0	-2.3	-1.6	0.8
Right kidney weight	2.6	7.3	9.3	2.7	2.7	2.7	-2.7	3.0	-2.7	-2.5	-2.6	-3.0	-2.4	2.6
Cocaine induced anxiety	1.1	1.3	2.5	1.1	1.1	1.1	-1.1	1.6	-1.1	-1.0	-1.1	-1.2	-0.9	1.0
Post-drug Anxiety	5.5	6.1	8.1	2.5	2.5	2.5	-2.5	2.8	-2.4	-2.5	-2.4	-2.5	-2.3	2.3
Baseline Anxiety	0.9	1.0	1.1	1.0	1.0	1.0	-1.0	0.9	-1.0	-1.0	-1.0	-0.9	-0.9	1.0
Tail length	0.1	0.2	0.5	-0.6	-0.6	-0.6	0.6	-0.2	0.6	0.3	0.6	-0.1	0.2	-0.7
Length with tail	1.9	7.1	8.4	2.7	2.7	2.7	-2.7	2.9	-2.7	-2.5	-2.7	-2.9	-2.3	2.6
Length without tail	6.8	14.8	16.9	4.0	4.0	4.1	-4.0	3.8	-4.1	-3.4	-4.1	-3.4	-3.1	4.1
Times rat made contact with spout	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	-0.3	0.4	0.1	0.4	0.1	0.1	-0.4
Lifetime Intake	2.9	3.3	3.7	-1.9	-1.9	-1.9	1.9	-1.6	1.9	1.7	1.9	1.5	1.6	-1.8
Liver weight, left	1.7	2.8	3.1	1.7	1.8	1.8	-1.8	1.6	-1.7	-1.6	-1.6	-1.3	-1.6	1.7
Liver weight, right	1.6	2.6	3.0	1.6	1.6	1.6	-1.6	1.7	-1.6	-1.6	-1.6	-1.7	-1.5	1.5
Locomotor activity	1.2	2.0	2.4	-1.5	-1.5	-1.5	1.5	-1.1	1.5	1.6	1.4	0.6	1.5	-1.4
Locomotor testing distance	3.3	5.5	6.5	-2.5	-2.5	-2.5	2.5	-2.1	2.4	2.6	2.2	1.8	2.5	-2.2
Locomotor testing rearing	2.5	3.8	4.3	-2.1	-2.1	-2.1	2.1	-1.8	2.0	2.0	1.9	1.6	2.0	-1.9
Locomotion in novel chamber	1.3	1.6	3.5	1.2	1.2	1.1	-1.1	1.3	-0.8	-1.8	-0.8	-1.4	-1.9	0.5
Locomotion in novel chamber post-restriction	0.2	0.2	0.6	0.4	0.4	0.3	-0.3	0.5	-0.2	-0.7	-0.2	-0.6	-0.8	-0.0
Fecal boli incidents, locomotor time 1	1.9	2.1	2.5	-1.6	-1.5	-1.6	1.6	-1.3	1.6	1.3	1.6	1.2	1.1	-1.6
Change in fecal boli incidents, locomotor task	1.2	1.1	1.8	1.1	1.1	1.1	-1.1	1.0	-1.2	-0.6	-1.2	-0.7	-0.5	1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	0.1	0.1	0.1	-0.1	-0.1	-0.3	0.5	-0.4	0.5	0.6	0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	-0.1	0.0	0.1	-0.1	-0.0	0.1
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.5	-0.5	-0.5	0.5	-0.7	0.4	0.7	0.6	0.6	0.7	-0.3
Rest time, locomotor task time 1	0.6	0.6	0.9	-0.8	-0.8	-0.7	0.7	-1.0	0.6	1.0	0.7	0.8	1.0	-0.5
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	0.1	0.2	-0.1	-0.0	-0.2	-0.1	-0.3	0.1	-0.0	0.2
Vertical activity count, locomotor time 1	1.3	1.3	1.8	1.2	1.2	1.2	-1.2	1.3	-1.1	-1.2	-1.2	-1.0	-1.1	1.1
Time >=10cm from walls, locomotor time 2	0.5	0.6	0.8	-0.8	-0.8	-0.8	0.8	-0.5	0.9	0.6	0.8	0.5	0.5	-0.9
Bouts of movement, locomotor time 2	3.0	3.2	3.9	1.8	1.8	1.8	-1.8	1.7	-1.7	-2.0	-1.6	-1.8	-1.9	1.5
Total resting periods, locomotor time 2	3.4	3.6	4.4	2.0	2.0	1.9	-1.9	1.8	-1.8	-2.1	-1.7	-1.9	-2.1	1.6
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	-0.4	-0.1	0.3	-0.1	0.4	0.3	0.2
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.1	0.2	0.2	0.2	0.1	0.2	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.1	0.1	0.1	-0.1	0.4	-0.0	-0.4	-0.1	-0.4	-0.5	-0.1
Light reinforcement 1	2.2	3.9	5.9	-2.1	-2.1	-2.1	2.1	-1.9	2.3	1.3	2.3	1.5	1.1	-2.4
Light reinforcement 2	0.5	0.6	1.7	-0.8	-0.8	-0.8	0.8	-0.2	1.1	-0.0	1.2	-0.3	-0.3	-1.3
Bone: marrow area	7.8	16.9	18.4	4.3	4.3	4.3	-4.3	4.2	-4.2	-4.0	-4.2	-3.7	-3.8	4.0
Bone: maximum diameter	2.6	4.8	6.3	2.3	2.3	2.3	-2.3	2.1	-2.4	-1.8	-2.5	-1.7	-1.6	2.4
Bone: maximum force	15.7	27.1	29.3	5.4	5.4	5.4	-5.4	5.4	-5.2	-5.1	-5.1	-5.0	-4.8	4.9
Bone: maximum moment	17.0	29.3	31.7	5.6	5.6	5.6	-5.6	5.6	-5.4	-5.4	-5.3	-5.3	-5.1	5.1
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1	0.1	0.0	0.1	-0.2	0.0	-0.2
Mean num. licks in bursts	0.3	0.4	1.5	0.4	0.5	0.4	-0.4	0.8	-0.3	-0.8	-0.1	-1.2	-0.8	0.1
Cd content in liver	0.8	0.8	1.0	-0.9	-0.9	-0.9	0.9	-1.0	1.0	0.8	0.9	0.9	0.7	-1.0
Co content in liver	0.8	0.9	1.2	-1.0	-1.0	-1.1	1.0	-0.9	1.1	0.8	1.1	0.5	0.7	-1.1
Cu content in liver	0.4	0.5	0.8	0.8	0.8	0.8	-0.8	0.6	-0.9	-0.4	-0.7	-0.3	-0.3	0.9
Fe content in liver	0.6	0.7	1.1	-0.9	-0.9	-0.9	0.9	-0.8	0.8	1.0	0.8	0.8	1.0	-0.6
K content in liver	0.1	0.1	0.3	0.2	0.2	0.2	-0.2	0.0	-0.4	0.2	-0.3	0.1	0.3	0.5
Mg content in liver	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.3	-0.5	0.2	0.5	0.1	0.5	0.5	-0.1
Mn content in liver	0.1	0.1	0.2	0.4	0.4	0.4	-0.4	0.4	-0.4	-0.4	-0.4	-0.4	-0.3	0.4
Na content in liver	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	-0.4	0.3	0.5	0.3	0.5	0.5	-0.2
Rb content in liver	1.3	1.6	3.3	-1.1	-1.1	-1.1	1.1	-1.4	0.9	1.7	0.8	1.7	1.8	-0.6
Se content in liver	1.4	1.7	3.2	-1.2	-1.2	-1.2	1.2	-1.5	1.0	1.5	0.9	1.8	1.6	-0.8
Sr content in liver	0.1	0.1	0.2	0.3	0.3	0.3	-0.3	0.1	-0.3	-0.1	-0.5	0.1	-0.1	0.4
Zn content in liver	2.7	3.0	3.5	-1.8	-1.8	-1.8	1.8	-1.8	1.7	1.9	1.6	1.7	1.8	-1.5
Bone: minimum diameter	9.2	17.1	18.5	4.3	4.3	4.3	-4.3	4.2	-4.2	-4.1	-4.1	-3.8	-3.9	3.9
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.3	-0.2	0.4	-0.0	0.5	-0.0	-0.2	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.4	0.4	0.4	-0.4	0.3	-0.5	-0.1	-0.5	-0.1	-0.0	0.5
Total zone transitions, hab. session 1	0.2	0.3	0.5	-0.6	-0.6	-0.6	0.6	-0.5	0.6	0.3	0.7	0.4	0.2	-0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.5	-0.1	-0.1	-0.1	0.1	-0.3	-0.1	0.6	-0.2	0.6	0.7	0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.4	-0.3	0.5	0.6	0.4
Time in familiar zone, hab. session 2	0.9	0.9	1.8	0.9	0.9	0.9	-0.9	1.0	-0.7	-1.3	-0.6	-1.2	-1.3	0.5
Time in novel zone, hab. session 2	0.9	0.9	2.0	-0.8	-0.8	-0.8	0.8	-1.0	0.6	1.3	0.5	1.3	1.4	-0.3
Total zone transitions, hab. session 2	0.3	0.4	0.4	-0.6	-0.6	-0.6	0.6	-0.6	0.6	0.6	0.6	0.6	0.6	-0.6
Total locomotion distance, hab. session 2	0.2	0.3	0.7	-0.4	-0.4	-0.4	0.4	-0.6	0.3	0.7	0.1	0.8	0.8	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.4	-0.2	-0.3	-0.2	0.2	-0.4	0.1	0.5	-0.1	0.6	0.6	-0.0
Novel to familiar place preference ratio	1.6	1.7	1.9	1.4	1.4	1.4	-1.4	1.2	-1.4	-1.2	-1.3	-1.0	-1.1	1.3
Novelty place preference	1.1	1.1	1.4	1.1	1.1	1.1	-1.1	0.9	-1.2	-0.9	-1.1	-0.7	-0.8	1.2
Time in novel zone, NPP test	0.8	0.8	1.2	1.0	1.0	1.0	-1.0	0.8	-1.1	-0.8	-1.0	-0.5	-0.7	1.1
Total zone transitions, NPP test	1.9	2.8	3.9	-1.7	-1.6	-1.6	1.6	-1.6	1.4	2.0	1.4	1.9	2.0	-1.2
Total locomotion distance, NPP test	2.4	3.3	5.1	-1.8	-1.8	-1.7	1.8	-2.0	1.5	2.2	1.3	2.2	2.3	-1.2
Locomotion velocity, NPP test	1.5	2.1	3.5	-1.4	-1.4	-1.3	1.4	-1.6	1.1	1.8	1.0	1.8	1.9	-0.9
Intraocular pressure	6.9	9.6	11.0	-3.3	-3.3	-3.3	3.3	-3.0	3.3	2.7	3.3	2.7	2.5	-3.3
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.3	0.3	0.3	-0.3	0.1	-0.3	-0.5	-0.3	-0.1	-0.5	0.2
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	-0.1	-0.0	-0.3	-0.0	0.0	-0.3	-0.0
Parametrial fat weight	2.0	3.9	4.7	-2.0	-2.0	-2.1	2.1	-2.2	2.1	1.7	2.1	1.7	1.5	-2.1
Pavlov. Cond. lever latency	0.1	0.2	0.5	0.3	0.3	0.3	-0.3	0.1	-0.5	0.3	-0.4	0.4	0.4	0.7
Pavlov. Cond. magazine entry latency	0.3	0.4	1.3	0.4	0.4	0.3	-0.4	0.6	-0.1	-1.0	-0.0	-1.1	-1.1	-0.1
Pavlov. Cond. change in total contacts	0.4	0.4	1.5	0.3	0.3	0.3	-0.3	0.6	-0.0	-1.1	-0.0	-1.2	-1.2	-0.3
Pavlov. Cond. index score	0.2	0.3	0.9	0.2	0.2	0.2	-0.2	0.4	0.1	-0.8	-0.0	-0.9	-0.9	-0.3
Pavlov. Cond. latency score	0.1	0.2	0.7	0.1	0.1	0.1	-0.1	0.2	0.2	-0.7	0.0	-0.8	-0.8	-0.4
Pavlov. Cond. lever contacts	0.4	0.5	1.3	-0.6	-0.6	-0.7	0.7	-0.4	0.9	-0.1	0.9	-0.3	-0.3	-1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.0	-0.0	0.0	-0.0	-0.3	-0.2	0.5	-0.2	0.7	0.6	0.4
Pavlov. Cond. intertrial magazine entries	1.9	2.2	6.1	-1.2	-1.2	-1.1	1.1	-1.6	0.7	2.3	0.6	2.2	2.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	0.5	0.5	0.5	-0.5	0.7	-0.3	-1.0	-0.3	-1.2	-1.1	0.0
Pavlov. Cond. response bias	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.1	0.1	0.3	-0.4	0.3	-0.6	-0.6	-0.5
Pavlov. Cond. lever latency	0.4	0.6	2.4	0.5	0.5	0.4	-0.5	0.8	-0.2	-1.0	-0.1	-1.5	-1.1	0.0
Pavlov. Cond. magazine entry latency	0.6	0.7	1.8	0.8	0.8	0.8	-0.8	0.3	-1.1	0.0	-1.1	0.6	0.2	1.3
Pavlov. Cond. change in total contacts	0.8	1.1	1.6	1.2	1.2	1.2	-1.2	0.8	-1.2	-0.8	-1.3	-0.3	-0.7	1.3
Pavlov. Cond. index score	0.3	0.4	1.5	0.4	0.3	0.4	-0.4	-0.2	-0.7	0.5	-0.8	1.2	0.7	1.0
Pavlov. Cond. latency score	0.4	0.4	1.5	0.4	0.4	0.4	-0.4	-0.2	-0.7	0.4	-0.8	1.2	0.7	1.0
Pavlov. Cond. lever contacts	0.5	0.7	2.4	-0.6	-0.7	-0.6	0.6	-1.0	0.5	1.0	0.4	1.6	1.0	-0.3
Pavlov. Cond. magazine entry number	1.1	1.4	3.3	-1.2	-1.2	-1.3	1.2	-0.7	1.5	0.3	1.6	-0.4	0.0	-1.8
Pavlov. Cond. intertrial magazine entries	4.2	5.4	7.4	-2.5	-2.5	-2.5	2.5	-2.2	2.7	1.9	2.6	1.4	1.7	-2.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.5	0.7	0.6	0.7	-0.7	0.1	-0.9	0.2	-1.0	0.9	0.4	1.2
Pavlov. Cond. response bias	0.2	0.3	1.6	-0.3	-0.3	-0.3	0.3	-0.6	0.1	0.6	0.1	1.3	0.7	0.0
Time in closed arm before self-admin	1.3	1.5	1.6	1.3	1.3	1.3	-1.3	1.3	-1.3	-1.1	-1.2	-1.2	-1.1	1.2
Time in closed arm after self-admin	0.6	0.6	0.8	0.9	0.9	0.9	-0.9	0.5	-0.9	-0.7	-0.9	-0.8	-0.6	0.9
Time in open arm before self-admin	0.5	0.6	0.9	0.7	0.7	0.7	-0.7	0.8	-0.9	-0.3	-0.9	-0.9	-0.1	1.0
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.5	-0.2	0.5	0.5	0.6	0.3	0.5	-0.5
Bone: periosteal estimation	11.2	23.2	25.4	5.0	5.0	5.0	-5.0	4.9	-5.0	-4.6	-5.0	-4.3	-4.3	4.8
Bone: periosteal perimeter	10.0	16.6	18.1	4.3	4.2	4.2	-4.2	4.0	-4.1	-4.1	-4.1	-3.7	-3.8	3.9
Bone: post-yield work	9.3	12.7	13.7	3.7	3.7	3.7	-3.7	3.7	-3.6	-3.5	-3.5	-3.3	-3.3	3.4
Progressive ratio test 1 active lever presses	6.7	7.0	9.2	-2.7	-2.7	-2.7	2.7	-2.5	2.4	3.0	2.4	2.9	3.0	-2.1
Progressive ratio test 1 breakpoint	6.0	6.3	7.9	-2.5	-2.6	-2.5	2.5	-2.4	2.3	2.8	2.3	2.7	2.8	-2.0
Progressive ratio test 1 inactive lever presses	3.2	3.5	4.7	-2.0	-2.0	-2.0	2.0	-1.6	2.0	1.7	2.2	1.5	1.5	-2.0
Progressive ratio test 2 active lever presses	2.6	2.8	3.2	-1.8	-1.8	-1.8	1.8	-1.4	1.8	1.5	1.8	1.5	1.4	-1.7
Progressive ratio test 2 breakpoint	3.1	3.5	4.1	-2.0	-2.0	-2.0	2.0	-1.6	2.0	1.7	2.0	1.6	1.5	-2.0
Progressive ratio test 2 inactive lever presses	2.1	2.5	3.6	-1.7	-1.7	-1.7	1.7	-1.3	1.8	1.2	1.9	1.2	1.0	-1.8
Incentive Sensitization - Responses	0.1	0.1	0.4	0.1	0.1	0.1	-0.1	0.4	0.0	-0.5	0.1	-0.4	-0.6	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.0	0.0	-0.0	0.0	0.3	0.2	-0.4	0.2	-0.3	-0.6	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.6	-0.3	-0.3	-0.2	0.2	-0.8	0.1	0.5	0.2	0.8	0.6	0.0
Progressive ratio	0.4	0.5	1.3	-0.5	-0.6	-0.5	0.5	-0.6	0.3	1.0	0.2	1.1	1.1	-0.1
Food seeking constrained by brief footshock	0.8	1.0	2.2	-1.0	-1.0	-0.9	0.9	-0.9	0.8	1.4	0.8	1.1	1.5	-0.5
Seeking ratio, punishment vs. effort	0.0	0.1	0.3	0.1	0.1	0.1	-0.1	0.2	-0.0	-0.3	0.1	-0.5	-0.4	-0.1
Retroperitoneal fat weight	0.8	2.7	3.7	-1.6	-1.6	-1.6	1.6	-1.9	1.5	1.9	1.3	1.7	1.9	-1.2
Reaction time number correct	1.6	2.3	2.8	1.6	1.6	1.6	-1.6	1.5	-1.6	-1.4	-1.7	-1.2	-1.2	1.6
Reaction time mean minus median	7.9	10.5	11.6	-3.4	-3.4	-3.4	3.4	-3.4	3.4	2.9	3.4	3.0	2.7	-3.3
Reaction time mean minus median AUC	5.6	7.2	8.2	-2.8	-2.8	-2.8	2.8	-2.9	2.8	2.4	2.8	2.6	2.2	-2.7
Reaction time num false alarms	1.7	2.2	2.6	-1.5	-1.6	-1.5	1.6	-1.6	1.5	1.5	1.4	1.5	1.4	-1.4
Reaction time num false alarms AUC	2.1	2.9	3.2	-1.8	-1.8	-1.8	1.8	-1.8	1.8	1.6	1.7	1.6	1.5	-1.7
Reaction time trials correct on left	1.6	2.3	2.8	1.6	1.6	1.6	-1.6	1.5	-1.6	-1.4	-1.7	-1.2	-1.2	1.6
Reaction time trials on left	1.3	1.8	2.3	1.4	1.4	1.4	-1.4	1.3	-1.5	-1.2	-1.5	-1.1	-1.1	1.4
Reaction time mean	0.7	1.0	1.3	-1.1	-1.1	-1.1	1.1	-1.1	1.0	1.0	1.0	0.9	0.9	-1.0
Reaction time mean AUC	0.4	0.6	0.7	-0.8	-0.8	-0.8	0.8	-0.8	0.8	0.7	0.7	0.5	0.6	-0.7
Median of all reaction times	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.0	-0.1	-0.0	0.0	-0.1	-0.1	0.0	0.0
Reaction time omissions	9.3	12.8	14.2	-3.8	-3.8	-3.8	3.8	-3.5	3.7	3.4	3.7	3.0	3.1	-3.6
Reaction time false alarm rate	2.6	3.6	4.1	-2.0	-2.0	-2.0	2.0	-1.9	2.0	1.7	2.0	1.7	1.6	-2.0
Reaction time premature initiation rate	6.2	8.3	10.1	-3.1	-3.1	-3.1	3.1	-2.5	3.1	2.7	3.2	2.0	2.4	-3.1
Reaction time premature initiations	2.6	3.7	4.5	-2.1	-2.0	-2.1	2.1	-1.5	2.1	1.8	2.1	1.2	1.6	-2.1
Std. dev. reaction times	6.1	8.5	9.4	-3.0	-3.0	-3.0	3.0	-3.1	3.0	2.8	3.0	2.7	2.5	-2.9
Reaction time trials completed	1.3	1.8	2.3	1.4	1.4	1.4	-1.4	1.3	-1.5	-1.2	-1.5	-1.1	-1.1	1.4
Reaction time trials AUC	2.0	2.9	3.5	1.8	1.8	1.8	-1.8	1.7	-1.8	-1.5	-1.9	-1.4	-1.4	1.8
Run reversals in cocaine runway, females	0.2	0.2	0.5	0.3	0.3	0.2	-0.3	0.4	-0.1	-0.6	0.1	-0.6	-0.7	-0.1
Run reversals in cocaine runway, males	1.4	1.4	1.8	-1.2	-1.2	-1.2	1.2	-1.4	1.2	0.9	1.2	1.3	0.8	-1.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.1	0.1	0.1	0.1	-0.3	0.1	-0.1
Latency to leave start box in cocaine runway, F	1.7	1.9	2.2	-1.5	-1.5	-1.5	1.5	-1.3	1.4	1.4	1.3	0.8	1.3	-1.4
Latency to leave start box in cocaine runway, M	2.1	2.0	2.2	1.5	1.5	1.5	-1.5	1.3	-1.4	-1.5	-1.4	-1.2	-1.5	1.3
Std. dev. time between licks in bursts	1.3	1.5	1.7	-1.3	-1.3	-1.3	1.3	-1.2	1.3	1.2	1.1	1.1	1.1	-1.2
Total sessions with >9 infusions	1.6	1.7	1.9	-1.3	-1.4	-1.4	1.4	-1.3	1.3	1.3	1.3	1.3	1.3	-1.2
Short access day 1 total inactive lever presses	1.6	1.8	2.0	-1.4	-1.4	-1.4	1.4	-1.3	1.4	1.3	1.4	1.2	1.2	-1.4
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.2	-0.1	-0.2	0.1	-0.3	0.3	-0.2	0.4	-0.1	-0.3	-0.4
Short access day 1 total infusions	0.3	0.3	0.7	-0.5	-0.6	-0.5	0.5	-0.5	0.4	0.8	0.4	0.7	0.9	-0.3
Short access day 10 total infusions	2.0	2.2	2.9	-1.5	-1.5	-1.5	1.5	-1.5	1.3	1.7	1.3	1.7	1.7	-1.1
Short access total infusions	1.3	1.5	2.0	-1.2	-1.2	-1.2	1.2	-1.2	1.1	1.4	1.0	1.3	1.4	-0.9
Short access day 1 locomotion	0.2	0.3	0.3	-0.5	-0.5	-0.5	0.5	-0.5	0.5	0.6	0.5	0.5	0.5	-0.4
Short access day 10 total locomotion	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.4	-0.2	0.3	0.5	0.4	0.4	0.5	-0.3
Short access total locomotion	0.6	0.6	0.7	-0.8	-0.8	-0.8	0.8	-0.8	0.8	0.8	0.9	0.7	0.7	-0.7
One hour access (0.3 mA shock)	0.2	0.3	0.8	-0.5	-0.5	-0.5	0.5	-0.2	0.7	-0.1	0.8	-0.2	-0.2	-0.9
Compulsive drug intake	1.4	1.4	1.7	1.2	1.3	1.2	-1.2	1.0	-1.1	-1.3	-1.2	-1.3	-1.3	1.0
One hour access (shock baseline)	0.2	0.2	0.6	-0.5	-0.5	-0.5	0.5	-0.1	0.6	0.1	0.7	-0.0	-0.1	-0.8
Social response proportion	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.4	-0.4	0.4	0.3	0.5	0.1	0.3	-0.5
Social responses	7.6	9.8	11.0	-3.3	-3.3	-3.3	3.3	-3.2	3.3	2.8	3.3	2.8	2.5	-3.3
Social time	0.1	0.1	0.8	0.2	0.2	0.2	-0.2	0.4	-0.1	-0.4	0.2	-0.9	-0.5	-0.1
Soleus weight	0.8	2.4	3.3	1.5	1.6	1.5	-1.5	1.6	-1.4	-1.7	-1.3	-1.8	-1.8	1.2
Bone: stiffness	18.9	29.8	31.8	5.6	5.6	5.6	-5.6	5.6	-5.4	-5.5	-5.3	-5.5	-5.3	5.0
Tibialis anterior weight	1.6	5.4	10.6	2.1	2.1	2.0	-2.1	2.6	-1.6	-3.1	-1.4	-3.3	-3.2	1.0
Time to tail flick, vehicle, before self-admin	0.7	0.8	0.8	-0.9	-0.9	-0.9	0.9	-0.8	0.9	0.9	0.9	0.8	0.8	-0.9
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.0	0.6	0.7	0.6	-0.6	0.9	-0.6	-0.7	-0.5	-1.0	-0.7	0.4
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.4	-0.0	0.4	0.4	0.6	0.1	0.3	-0.5
Time to tail flick, test, after self-admin	0.5	0.5	1.2	0.7	0.7	0.7	-0.7	0.9	-0.5	-0.9	-0.4	-1.1	-0.9	0.4
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	0.9	0.7	0.7	0.7	-0.7	0.8	-0.6	-0.8	-0.6	-0.9	-0.8	0.5
Delta time to tail flick, test, before/after SA	0.4	0.3	0.8	0.6	0.5	0.5	-0.5	0.4	-0.4	-0.9	-0.4	-0.6	-0.9	0.2
Tibia length	6.1	17.2	20.4	4.4	4.3	4.4	-4.4	4.1	-4.4	-3.7	-4.5	-3.5	-3.4	4.4
Ambulatory time before self-admin	4.0	4.2	4.7	-2.2	-2.1	-2.1	2.1	-1.9	2.0	2.1	2.0	1.9	2.0	-1.9
Ambulatory time after self-admin	2.0	2.2	3.1	-1.5	-1.5	-1.5	1.5	-1.8	1.5	1.3	1.4	1.6	1.2	-1.4
Bone: tissue strength	1.9	1.9	2.5	1.4	1.4	1.4	-1.4	1.5	-1.3	-1.4	-1.2	-1.6	-1.4	1.2
Total heroin consumption	1.7	2.0	2.3	1.5	1.5	1.5	-1.5	1.4	-1.5	-1.1	-1.4	-1.4	-1.0	1.5
Bone: trabecular number	6.1	9.5	11.9	3.3	3.2	3.3	-3.3	3.0	-3.3	-2.7	-3.4	-2.5	-2.5	3.3
Bone: trabecular spacing	2.3	3.0	3.7	-1.8	-1.8	-1.8	1.8	-1.9	1.9	1.4	1.9	1.6	1.2	-1.9
Bone: trabecular thickness	0.2	0.2	0.9	0.0	0.0	-0.0	0.0	0.4	0.3	-0.7	0.3	-0.9	-0.8	-0.5
Bone: trabecular tissue density	0.2	0.3	1.1	0.1	0.1	0.1	-0.1	0.3	0.2	-0.9	0.2	-0.8	-1.1	-0.5
Water consumed over 24 hours	0.0	0.0	0.1	-0.0	-0.0	0.0	0.0	-0.1	-0.1	0.3	-0.2	0.3	0.4	0.2
Number of responses in last shaping day	0.1	0.1	0.5	0.2	0.2	0.2	-0.2	0.3	-0.1	-0.6	-0.0	-0.5	-0.7	-0.1